Cancer Network
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Updated regimens on par with standard therapy in diffuse large B-cell lymphoma
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Researchers are exploring ways to manipulate rituximab (Rituxan) when added to the current standard therapy for diffuse large B-cell lymphoma, specifically shortening the number of treatment days. Preliminary results of a phase III trial showed that rituximab plus CHOP over a 14-day cycle achieved similar response rates and comparable toxicity compared to CHOP on a 21-day cycle in newly diagnosed patients. (Source: Cancer Network)
Source: Cancer Network - November 21, 2009 Category: Cancer & Oncology Source Type: info
Experts contest review article declaring breast MRI causes more harm than good by encouraging radical Rx
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A review article asserting breast MRI does not improve surgical planning, reduce follow-up surgeries, or reduce the risk of local recurrences drew the ire of the breast imaging community. (Source: Cancer Network)
Source: Cancer Network - November 20, 2009 Category: Cancer & Oncology Source Type: info
JAMA article reignites debate over screening
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In a prepared statement, Dr. Brawley said the ACS stands by its recommendation that women 40 years and older should receive annual mammography screening, and women at high risk should talk with their doctors about when screening should begin based on their family history. (Source: Cancer Network)
Source: Cancer Network - November 20, 2009 Category: Cancer & Oncology Source Type: info
Ultrasound targets lymph node recurrence in breast cancer
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Ultrasound is an effective way to monitor lymph node recurrence after breast cancer surgery, South Korean researchers reported. Regional lymph node recurrence affects just 2% to 16% of patients with any stage of breast cancer, but is difficult to manage and associated with poor prognosis. (Source: Cancer Network)
Source: Cancer Network - November 20, 2009 Category: Cancer & Oncology Source Type: info
Radiation Rx prevents melanoma’s invasion of lymph nodes
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CHICAGO—Radiation of the lymph nodes of high-risk melanoma patients appears to significantly reduce the risk that cancer will recur in those nodes, researchers said at ASTRO 2009. The study was deemed practice-changing, representing the first advance in the management of melanoma in nearly two decades. (Source: Cancer Network)
Source: Cancer Network - November 19, 2009 Category: Cancer & Oncology Source Type: info
Making the most of gastric imaging requires clear communication between oncologists and radiologist
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There is a complex array of tests for imaging the abdomen, but there are really only three things that oncologists need to tell radiologists in order to get the most from these imaging studies, according to Fergus V. Coakley, MD, chief of abdominal imaging (Source: Cancer Network)
Source: Cancer Network - November 19, 2009 Category: Cancer & Oncology Source Type: info
Postsurgical H&N patients manage to complete radiotherapy
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Head and neck patients who undergo surgery first are more likely to complete radiation therapy, according to Seattle-based researchers. Megan Dann Fesinmeyer, PhD, MPH, and colleagues noted that radiation dose and treatment duration correlated with tumor control and survival, but that breaks in radiotherapy have been associated with inferior tumor control. (Source: Cancer Network)
Source: Cancer Network - November 18, 2009 Category: Cancer & Oncology Source Type: info
Moving at the speed of science
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Owen Witte, MD, has been a California resident for nearly 35 years, but there’s nothing laid-back about him. The director of the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research retains the rapid fire speech of a native New Yorker. Although it was getting toward late afternoon when Dr. Witte met with Oncology News International, he ushered a steady stream of visitors into and out of his office at the University of California, Los Angeles. When he spoke about his work, it was with the same energy that no doubt drew him to science in the first place. (Source: Cancer Network)
Source: Cancer Network - November 18, 2009 Category: Cancer & Oncology Source Type: info
International trials: Panitumumab delays disease progression in colon cancer mets
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BERLIN—A pair of colon cancer trials using panitumumab (Vectibix) not only proved the efficacy of the drug in patients with nonmutated KRAS but also highlighted the importance of ascertaining KRAS status. Trial 181 evaluated panitumumab in combination with FOLFIRI as a second-line treatment for metastatic colorectal cancer, while trial 203 paired the anti-EGFR agent with FOLFOX4 as first-line treatment. (Source: Cancer Network)
Source: Cancer Network - November 18, 2009 Category: Cancer & Oncology Source Type: info
Women with small HER2+ breast ca face recurrence risk
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Researchers in the U.S. and Italy report that women with HER2-positive breast cancers that are 1 cm or less in diameter and are node-negative have a risk of recurrence that is two to five times greater than that of women with HER2-negative breast cancers (J Clin Oncol online, November 2, 2009). (Source: Cancer Network)
Source: Cancer Network - November 17, 2009 Category: Cancer & Oncology Source Type: info
Imaging experts weigh in on screening controversy
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Despite the hubbub, breast imaging researchers saw nothing new in the findings of Dr. Esserman’s group. Daniel Kopans, MD, a professor of radiology at Boston’s Massachusetts General Hospital, called her observation about mammography catching nonlethal cancers but missing aggressive ones “a fundamental concept that is older than I am. Mammography saves lives by finding moderate- and slow-growing cancer that will kill in five or more years without diagnosis and treatment,” according to Dr. Kopans. (Source: Cancer Network)
Source: Cancer Network - November 17, 2009 Category: Cancer & Oncology Source Type: info
Moderate marijuana use may tamp risk of H&N cancer
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Cannabinoids, which are a byproduct of marijuana smoke, have been recognized to have potential antitumor properties, but evidence of a relationship between marijuana use and the induction of head and neck squamous cell carcinoma has been inconsistent. (Source: Cancer Network)
Source: Cancer Network - November 17, 2009 Category: Cancer & Oncology Source Type: info
PET gains medical and political traction in cancer prognosis
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PET/CT is gaining recognition both medically and politically when it comes to sizing up cancer. And the timing for oncologists couldn’t be better. (Source: Cancer Network)
Source: Cancer Network - November 16, 2009 Category: Cancer & Oncology Source Type: info
Prometheus releases trio of tissue-specific microRNA tests
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Prometheus Laboratories has launched the ProOncDx line of cancer diagnostic tests. ProOncDx TumorSource pinpoints the tissue of origin in metastatic tumors in a number of cancers including breast, brain, kidney, colon, liver, ovary, lung, pancreas, and prostate. The test measures the expression level of 48 microRNA biomarkers. (Source: Cancer Network)
Source: Cancer Network - November 16, 2009 Category: Cancer & Oncology Source Type: info
Pazopanib accepted by FDA as treatment for kidney cancer
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GlaxoSmithKline has received FDA approval for pazopanib (Votrient) for the treatment of patients with advanced renal cell carcinoma. The FDA’s approval of the angiogenesis inhibitor was based on data from a phase III clinical trial, which demonstrated that pazopanib reduced the risk of tumor progression or death by 54% compared with placebo and regardless of prior treatment. (Source: Cancer Network)
Source: Cancer Network - November 16, 2009 Category: Cancer & Oncology Source Type: info
Oncologists should look upon imaging as another biomarker, not just an anatomic picture
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Annick Van den Abbeele, MD, couldn’t believe her eyes. Dr. Van den Abbeele, the chief of radiology at Boston’s Dana-Farber Cancer Institute, had seen the patient just a month earlier. At that time, the 35-year-old woman had a gastrointestinal stromal tumor in her abdomen that was so large, she looked six months’ pregnant. But at the patient’s follow up FDG-PET study, the tumor was completely gone. (Source: Cancer Network)
Source: Cancer Network - November 16, 2009 Category: Cancer & Oncology Source Type: info
Study: A/C chemo takes toll on bones
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The skeletal health of pre-menopausal women with estrogen receptor-negative breast cancer took a beating after six cycles of doxorubicin (Doxil)/cyclophosphamide (A/C) chemotherapy. (Source: Cancer Network)
Source: Cancer Network - November 16, 2009 Category: Cancer & Oncology Source Type: info
New molecule interferes with heat shock protein activities
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Researchers had identified a small molecule that inhibits the heat shock protein HSP70. They also demonstrated in their animal experiment that the HSP inhibitor could stop tumor formation and significantly extend survival. (Source: Cancer Network)
Source: Cancer Network - November 16, 2009 Category: Cancer & Oncology Source Type: info
FDA approves cervical cancer vaccine
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Cervarix has won FDA approval for the prevention of cervical pre-cancers and cervical cancer associated with HPV-16 and HPV-18 for use in girls and young women (ages 10-25), according to GlaxoSmithKline. In clinical trials, the vaccine was shown to be 93% effective in the prevention of cervical pre-cancers associated with HPV -16 or 18, in women without evidence of current infection with, or prior exposure to, the same HPV type at the time of vaccination. (Source: Cancer Network)
Source: Cancer Network - November 16, 2009 Category: Cancer & Oncology Source Type: info
EC145 shows anti-tumor activity in ovarian cancer
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BELGRADE—Endocyte presented phase IIa data from its trial using EC145 (pegylated liposomal doxorubicin) in women with advanced-stage ovarian cancer at the 2009 European Society of Gynaecological Oncology. The study participants had a median o (Source: Cancer Network)
Source: Cancer Network - November 16, 2009 Category: Cancer & Oncology Source Type: info
Hysterecomy fails to offer better disease control
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A modified radical hysterectomy (class II) did not improve locoregional control and survival compared with simple extrafascial abdominal hysterectomy (class I). Investigators from University of Milano-Bicocca in Monza, Italy, randomized 520 patients with stage I endometrial cancer to class I or class II surgery. They found that the median length of parametria and vagina removed were 15 mm and 5 mm respectively for class I hysterectomy vs 20 mm and 15 mm for class II hysterectomy (P > .001). Operating time and blood loss were statistically significantly higher for class II hysterectomy. Five-year disease-free survival and o...
Source: Cancer Network - November 16, 2009 Category: Cancer & Oncology Source Type: info
Turmeric may induce cell death in esophageal cancer sans apoptosis
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Turmeric, or curcumin (diferuloylmethane), may be a favorable agent for the prevention and treatment of esophageal cancer, according to researchers at the Cork Cancer Research Center and Mercy University Hospital in Cork, Ireland. The authors noted that turmeric was able to induce cell death by a mechanism that is not reliant on apoptosis induction. (Source: Cancer Network)
Source: Cancer Network - November 16, 2009 Category: Cancer & Oncology Source Type: info
Astellas, Medivation team on prostate Rx
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Astellas has partnered with Medivation to co-develop and market the oral anti-androgen, MDV3100. In September, Medivation enrolled patients in the phase III AFFIRM trial, which is evaluating MDV3100 in 1,200 men with castration-resistant prostate cancer who were previously treated with docetaxel (Doxil) chemotherapy. (Source: Cancer Network)
Source: Cancer Network - November 16, 2009 Category: Cancer & Oncology Source Type: info
Pain relief with radiation Rx may come at too high a price
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An analysis by researchers at the University of Michigan Comprehensive Cancer Center shows that costs vary widely for different treatment regimens and from one delivery method to another. Yet receiving more treatments and spending extra on more sophisticated technology may do little good, at least when it comes to pain relief. (Source: Cancer Network)
Source: Cancer Network - November 16, 2009 Category: Cancer & Oncology Source Type: info
New technology unveiled at ASTRO 2009
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CHICAGO—Accuray introduced the CyberKnife VSI System. The system is designed to also include conventionally fractionated robotic intensity-modulated radiation therapy. (Source: Cancer Network)
Source: Cancer Network - November 16, 2009 Category: Cancer & Oncology Source Type: info
Stereotactic body radiation controls lung ca in frail patients
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CHICAGO—In lung cancer patients, stereotactic body radiation therapy achieved a 98% local control rate that persisted over three years in those who were too frail with comorbidities to undergo surgery, according to research presented at ASTRO 2009. (Source: Cancer Network)
Source: Cancer Network - November 16, 2009 Category: Cancer & Oncology Source Type: info
Elitek FDA-approved for recombinant uricolytic agent for tumor lysis
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Rasburicase (Elitek) has been granted FDA approval for the initial management of plasma uric acid (PUA) levels in adult patients with leukemia, lymphoma, and solid tumor malignancies. (Source: Cancer Network)
Source: Cancer Network - November 16, 2009 Category: Cancer & Oncology Source Type: info
Bone marrow aspiration enhances detection of leukemia cells
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Scientists in New Mexico are experimenting with a nanotechnology device that quantifies the amount of nanoparticle-bound tumor cells in a tissue sample and offers increased sensitivity to minimal residual disease (Cancer Res 69:6839-6847, 2009). (Source: Cancer Network)
Source: Cancer Network - November 16, 2009 Category: Cancer & Oncology Source Type: info
FDA fast tracks Rx for hard-to-treat peripheral T-cell lymphoma
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Allos Therapeutics has received accelerated FDA approval for Folotyn (pralatrexate) as a single-agent treatment in patients with relapsed or refractory peripheral T-cell lymphoma. (Source: Cancer Network)
Source: Cancer Network - November 16, 2009 Category: Cancer & Oncology Source Type: info
Infection control wins stimulus funds
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An investigator at Fred Hutchinson Cancer Center in Seattle has earned a $1.74 million grant under the American Recovery & Reinvestment Act of 2009. (Source: Cancer Network)
Source: Cancer Network - November 16, 2009 Category: Cancer & Oncology Source Type: info
ASCO seeks to turbo charge cancer research with new report
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Oncology is gaining ground on several fronts, thanks in large part to increased sophistication in the technology of cancer therapeutics, but also in how those technologies are applied. (Source: Cancer Network)
Source: Cancer Network - November 11, 2009 Category: Cancer & Oncology Source Type: info
Nilotinib Meets Primary Endpoint in Pivotal Trial Against Imatinib as First-Line Treatment in Chronic Myeloid Leukemia Patients
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Novartis announced recently that nilotinib (Tasigna) 200-mg capsules met its primary endpoint in the first head-to-head comparison with the company’s groundbreaking drug imatinib mesylate (Gleevec) tablets. Nilotinib produced faster and deeper responses than imatinib when given as first-line therapy for adult patients with newly diagnosed Philadelphia chromosome–positive chronic myeloid leukemia (Ph+ CML) in chronic phase. Nilotinib was well tolerated in the study. (Source: Cancer Network)
Source: Cancer Network - November 10, 2009 Category: Cancer & Oncology Source Type: info
Phase III Data Show Octreotide Reduced Risk of Disease Progression by 66% in Advanced Neuroendocrine Tumor Patients
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Data published in the Journal of Clinical Oncology show that patients with advanced neuroendocrine tumors (NET) of the midgut who were treated with octreotide acetate (Sandostatin LAR Depot) experienced a 66% reduction in risk of disease progression vs placebo. Octreotide is indicated to treat the diarrhea and flushing episodes associated with advanced carcinoid tumors. (Source: Cancer Network)
Source: Cancer Network - November 10, 2009 Category: Cancer & Oncology Source Type: info
Pazopanib Approved for Advanced Kidney Cancer
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The US Food and Drug Administration approved GlaxoSmithKline’s pazopanib (Votrient), the sixth drug to be approved for kidney cancer since 2005. (Source: Cancer Network)
Source: Cancer Network - November 10, 2009 Category: Cancer & Oncology Source Type: info
FDA Approves Cervical Cancer Vaccine
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The US Food and Drug Administration (FDA) has approved GlaxoSmithKline’s human papillomavirus bivalent (types 16 and 18) vaccine, recombinant (Cervarix) for the prevention of cervical precancers and cervical cancer associated with oncogenic human papillomavirus (HPV) types 16 and 18 for use in girls and young women (aged 10–25).
Women are at risk of HPV infecti (Source: Cancer Network)
Source: Cancer Network - November 10, 2009 Category: Cancer & Oncology Source Type: info
Rasburicase Approved to Manage Complications of Anticancer Therapy
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Sanofi-aventis US announced that the US Food and Drug Administration (FDA) has granted marketing approval for rasburicase (Elitek) to be used for the initial management of plasma uric acid (PUA) levels in adult patients with leukemia, lymphoma, and solid tumor malignancies who are receiving anticancer therapy expected to result in tumor lysis syndrome (TLS) and subsequent elevations of plasma uric acid. (Source: Cancer Network)
Source: Cancer Network - November 10, 2009 Category: Cancer & Oncology Source Type: info
Ofatumumab Receives Approval for CLL
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The US Food and Drug Administration approved ofatumumab (Arzerra) for patients with chronic lymphocytic leukemia (CLL) whose cancer is no longer being controlled by other forms of chemotherapy. The product was approved under the FDA’s accelerated approval process, which allows earlier approval of drugs that meet unmet medical needs. (Source: Cancer Network)
Source: Cancer Network - November 10, 2009 Category: Cancer & Oncology Source Type: info
Proton therapy report advises caution
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The limited evidence on the comparative effectiveness of proton-beam therapy, especially in comparison to other radiation-based treatment modalities, undermines the value of this up-and-coming technology, according to a comparative effectiveness report by the Agency for Healthcare Research and Quality. (Source: Cancer Network)
Source: Cancer Network - October 30, 2009 Category: Cancer & Oncology Source Type: info
Antidepressants continue to show increased inhibition of colorectal tumor cell growth
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Use of antidepressants, particularly selective serotonin reuptake inhibitors and possibly tricyclic antidepressants, is associated with a reduced risk of colorectal cancer, according to research by the Group Health Research Institute in Seattle. But it’s too soon to make specific recommendations on how to harness this potential value of these drugs in cancer prevention. (Source: Cancer Network)
Source: Cancer Network - October 29, 2009 Category: Cancer & Oncology Source Type: info
New class of alpha emitters takes aim at bone metastases
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A new class of cancer alpha-pharmaceuticals is approaching the marketplace, one built around the basis of radiotherapy itself. An isotope of radium, the element discovered more than a century ago by Pierre and Marie Curie, is the cornerstone of this new class of radiopharmaceuticals. (Source: Cancer Network)
Source: Cancer Network - October 29, 2009 Category: Cancer & Oncology Source Type: info
Cancer, not HPV vaccination, hastened death of UK girl
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Cancer killed a 14-year-old girl who died shortly after being given Cervarix as part of a national immunization program. Early reports speculated that there may have been a link between the shot and her death, but according to a coroner’s assessment, there was no indication that the culprit was the HPV vaccine, which is marketed by GlaxoSmithKline. The girl’s death was caused by malignant disease in the heart and lungs, according to the coroner’s report. (Source: Cancer Network)
Source: Cancer Network - October 29, 2009 Category: Cancer & Oncology Source Type: info
Who's News
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The AACR has appointed George Prendergast, PhD, as the editor-in-chief of Cancer Research. He is the president and CEO of Lankenau Institute for Medical Research in Wynnewood, Penn., and previously served as a senior editor and deputy editor for the journal. Dr. Prendergast will take up the five-year editorship in January 2010 (Source: Cancer Network)
Source: Cancer Network - October 29, 2009 Category: Cancer & Oncology Source Type: info
Takeda nabs priority review for Velcade
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Takeda announced that the FDA has agreed to consider an expedited review of the company’s request to update its label for bortezomib (Velcade) to include long-term survival data in patients with previously untreated multiple myeloma. (Source: Cancer Network)
Source: Cancer Network - October 29, 2009 Category: Cancer & Oncology Source Type: info
Obesity hinders treatment in pediatric leukemia
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Obesity may contribute to chemotherapy resistance and increasing relapse rates among children with leukemia, an animal study in Cancer Research (online, September 22, 2009) suggests. (Source: Cancer Network)
Source: Cancer Network - October 29, 2009 Category: Cancer & Oncology Source Type: info
Posaconazole reduces infection in AML patients
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The incidence of pneumonia and invasive pulmonary aspergillosis in acute myeloid leukemia patients was reduced when they were given posaconazole (Noxafil) as prophylaxis. (Source: Cancer Network)
Source: Cancer Network - October 29, 2009 Category: Cancer & Oncology Source Type: info
Global report warns of escalating cancer rate
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A coalition of international cancer experts is warning that the global cancer burden will double over the next two decades with an increasing concentration of cases in low-income and middle-income countries. (Source: Cancer Network)
Source: Cancer Network - October 29, 2009 Category: Cancer & Oncology Source Type: info
Stop and smell the volatile organic compounds in lung ca
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SAN FRANCISCO—Studies have identified specific volatile organic compounds in the breath of lung cancer patients, but the origin of those compounds is still ambiguous: Are they from the tumor itself, the tumor micro- (Source: Cancer Network)
Source: Cancer Network - October 29, 2009 Category: Cancer & Oncology Source Type: info
Juice Plus
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Despite the widespread perception that dietary supplements are safe, few products have been subjected to rigorous research. The potential risks of dietary supplement use are not known. (Source: Cancer Network)
Source: Cancer Network - October 24, 2009 Category: Cancer & Oncology Source Type: info
Sorafenib Plus Chemotherapy Significantly Prolongs Progression-Free Survival in Advanced Breas
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Bayer HealthCare Pharmaceuticals and Onyx Pharmaceuticals, Inc, announced the full results from their first collaborative group-sponsored randomized, double-blind, placebo-controlled phase II trial showing that sorafenib (Nexavar) tablets in combination with the oral chemotherapeutic agent, capecitabine (Xeloda), significantly extended progression-free survival in patients with advanced breast cancer. (Source: Cancer Network)
Source: Cancer Network - October 23, 2009 Category: Cancer & Oncology Source Type: info
Surgical Removal of Primary Tumor Improves Survival in Metastatic Breast Cancer Patients
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Removal of the primary breast tumor in women whose cancer has already metastasized can have a significant effect on their survival, Dutch researchers have found. Dr. Jetske Ruiterkamp, a surgical resident from the Jeroen Bosch Hospital, Den Bosch, The Netherlands, working under the supervision of Dr. Miranda Ernst, told Europe’s largest cancer congress, ECCO 15/ESMO 34, in Berlin that her research meant that women who were diagnosed at a late stage of the disease could expect to survive longer. (Source: Cancer Network)
Source: Cancer Network - October 23, 2009 Category: Cancer & Oncology Source Type: info
