Cancer ScienceThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the latest items in this publication.

Pages: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23

1133 records returned

In vitro and in vivo evidence that a combination of lapatinib plus S-1 is a promising treatment for pancreatic cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lapatinib is a small molecule inhibitor of both HER2 and the epidermal growth factor receptor (EGFR). We investigated the effect of treatment with lapatinib alone or in combination with a fluoropyrimidine derivative S-1 against pancreatic cancer. The HER2/EGFR expression in each of the four pancreatic cancer cell lines MiaPaca-2, PANC-1, Capan-1 and Capan-2 was measured by flow cytometry. The anti-tumor effects of lapatinib (30 mg/kg) and/or S-1 (10 mg/kg) were evaluated using female BALB/c nude mice xenografts generated using these four cell lines. Synergy between lapatinib and S-1 was examined by median effect analysis i...
Source: Cancer Science - November 20, 2009 Category: Cancer & Oncology Authors: Masahiro Komoto, Bunzo Nakata, Takafumi Nishii, Hidemi Kawajiri, Osamu Shinto, Ryosuke Amano, Nobuya Yamada, Masakazu Yashiro, Kosei Hirakawa Source Type: journals

Influence of GSTP1 I105V polymorphism on cumulative neuropathy and outcome of FOLFOX-4 treatment in Asian patients with colorectal carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Glutathione S-transferase P1 (GSTP1) participates in detoxification of potentially genotoxic compounds that may alter the efficacy and toxicity of platinum-based chemotherapy. We analyzed the influence of I105V polymorphism of GSTP1 on clinico-pathological features and outcomes in 166 Chinese patients with metastatic colorectal carcinoma who had been treated with first-line FOLFOX-4. Combined analysis of GSTP1 I105V, ERCC1-118, and XPD-751 polymorphisms was also conducted. The results showed that, in comparison with Caucasian populations, a remarkably lower prevalence of Val105 allele variants was noted (24.7%). Patients w...
Source: Cancer Science - November 19, 2009 Category: Cancer & Oncology Authors: Yen-Chung Chen, Cheng-Hwai Tzeng, Po-Min Chen, Jen-Kou Lin, Tzu-Chen Lin, Wei-Shone Chen, Jeng-Kae Jiang, Huann-Sheng Wang, Wei-Shu Wang Source Type: journals

Conditionally replicating adenovirus improves gene replication efficiency and anticancer effect of E1-deleted adenovirus carrying TRAIL in head and neck squamous cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, this combined strategy using CRAd and adenovirus carrying a therapeutic gene increased the gene transfer rate and enhanced antitumor effects. We expect that this combination strategy could be extended to a multitarget cancer gene therapy by combining multiple adenoviruses and CRAd. (Cancer Sci 2009) (Source: Cancer Science)
Source: Cancer Science - November 18, 2009 Category: Cancer & Oncology Authors: Seon-Hui Shim, Choon-Taek Lee, J. Hun Hah, Jae-Jung Lee, Seok-Woo Park, Dae Seog Heo, Myung-Whun Sung Source Type: journals

Novel human papillomavirus type 18 replicon and its application in screening the antiviral effects of cytokinesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, we developed a new system for the analysis of the HPV lifecycle. The new system consists of a novel HPV replicon and an organotypic "raft" culture, by which the HPV-DNA is maintained stably in normal human keratinocytes for a long period and the viral vegetative replication is reproduced. This system will benefit biochemical and genetic studies on the lifecycle of HPV and tumorigenesis. This system is also valuable in screening for antiviral compounds. We confirmed its usefulness by evaluating the antivirus effect of cytokines. (Cancer Sci 2009 00: 000[ndash]000) (Source: Cancer Science)
Source: Cancer Science - November 17, 2009 Category: Cancer & Oncology Authors: Ayano Satsuka, Satoshi Yoshida, Naoko Kajitani, Hiroyasu Nakamura, Hiroyuki Sakai Source Type: journals

Activity of sulfotransferase 1A1 is dramatically upregulated in patients with hepatocellular carcinoma secondary to chronic hepatitis B virus infectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study phenacetin, a probe drug (1 g for men and 0.85 g for women orally), was applied for the detection of sulfotransferase 1A1 (SULT1A1) and cytochrome P4501A2 (CYP1A2) activities in 82 healthy participants and 148 HCC, 106 cirrhosis, and 41 chronic hepatitis B patients. In addition, a prospective cohort study for susceptibility to HCC was performed in 205 patients with cirrhosis secondary to chronic HBV infection. Compared with the healthy participants, S.1A1 activity increased by 9.7-fold in the HCC patients (P < 0.01). CYP1A2 activity did not significantly differ between the healthy participants and HCC patient...
Source: Cancer Science - November 10, 2009 Category: Cancer & Oncology Authors: Xiang-Rui Wang, Zeng-Qiang Qu, Xiao-Dong Li, Hai-Lin Liu, Ping He, Bei-Xiong Fang, Jie Xiao, Wei Huang, Meng-Chao Wu Source Type: journals

Critical roles of T-LAK cell-originated protein kinase in cytokinesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We previously reported up-regulation of T-LAK cell-originated protein kinase (TOPK), a novel mitotic kinase, in the great majority of breast cancers. Here we report its critical roles in mitosis, especially in cytokinesis. We found that protein phosphatase 1 alpha (PP1[alpha]) inactivation by cyclin-dependent kinase 1 (CDK1)/cyclin B1 caused enhancement of autophosphorylation of TOPK and resulted in its activation at an early stage of mitosis. Then TOPK interacted with and phosphorylated p97, a member of the AAA+ family of ATPase proteins, through an interaction with p47 protein as an adaptor protein. Interestingly, knockd...
Source: Cancer Science - November 9, 2009 Category: Cancer & Oncology Authors: Jae-Hyun Park, Toshihiko Nishidate, Yusuke Nakamura, Toyomasa Katagiri Source Type: journals

Enhanced tumor growth in the NaS1 sulfate transporter null mouseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study has revealed increased tumor growth and an altered extracellular tumor matrix in hyposulfatemic Nas1[minus]/[minus] mice. These findings highlight the importance of blood sulfate levels as a possible modulator of tumor growth, and could lead to future cancer studies in humans with altered sulfate homeostasis. (Cancer Sci 2009; 00: 000[ndash]000) (Source: Cancer Science)
Source: Cancer Science - November 6, 2009 Category: Cancer & Oncology Authors: Paul Anthony Dawson, Allison Choyce, Christine Chuang, John Whitelock, Daniel Markovich, Graham Robert Leggatt Source Type: journals

Genome-wide DNA methylation profiles in precancerous conditions and cancersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Alterations of DNA methylation, which result in chromosomal instability and silencing of tumor-related genes, are among the most consistent epigenetic changes observed in human cancers. Analysis of tissue specimens has revealed that DNA methylation alterations participate in multistage carcinogenesis, even from the early and precancerous stages, especially in association with chronic inflammation and/or persistent viral infection, such as chronic hepatitis or liver cirrhosis resulting from infection with hepatitis B or C virus. DNA methylation alterations can account for the histological heterogeneity and clinicopathologic...
Source: Cancer Science - November 5, 2009 Category: Cancer & Oncology Authors: Yae Kanai Source Type: journals

Epigenetic regulation of the non-canonical Wnt pathway in acute myeloid leukemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Wnt5a is a member of the Wnt family of proteins that signals through the non-canonical Wnt/Ca2+pathway to suppress cyclin D1. Deregulation of this pathway has been found in animal models suggesting that it acts as tumour suppressor in acute myeloid leukemia (AML). Although DNA methylation is the main mechanism of regulation of the canonical Wnt pathway in AML, the role of WNT5A abnormalities has never been evaluated in this clinical setting. The methylation status of WNT5A promoter[ndash]exon 1 was analyzed by methylation-specific PCR and sequencing in eleven AML-derived cell lines and 252 AML patients. We observed WNT5A h...
Source: Cancer Science - October 29, 2009 Category: Cancer & Oncology Authors: Vanesa Martín, Ana Valencia, Xabier Agirre, Jose Cervera, Edurne San Jose-Eneriz, Amaia Vilas-Zornoza, Paula Rodriguez-Otero, Miguel A. Sanz, Concepción Herrera, Antonio Torres, Felipe Prosper, Jose Román-Gómez Source Type: journals

Fresh and pickled vegetable consumption and gastric cancer in Japanese and Korean populations: A meta-analysis of observational studiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
It is widely known that vegetable consumption contributes to reducing the risk of gastric cancer (GC). However, the incidence rates of GC remain high in both Japanese and Korean populations, even though they have a high consumption of total vegetables. This may be due to the fact that Japanese and Koreans mainly consume processed vegetables, such as cooked, salted, or pickled vegetables, rather than fresh vegetables. To determine whether the intakes of fresh and pickled vegetables have different effects on the risk of GC in Japanese and Korean populations, we carried out a meta-analysis of published epidemiological reports...
Source: Cancer Science - October 28, 2009 Category: Cancer & Oncology Authors: Hyun Ja Kim, Sun Young Lim, Jung-Sug Lee, Sohee Park, Aesun Shin, Bo Youl Choi, Taichi Shimazu, Manami Inoue, Shoichiro Tsugane, Jeongseon Kim Source Type: journals

Overexpression and involvement of special AT-rich sequence binding protein 1 in multidrug resistance in human breast carcinoma cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Special AT-rich sequence binding protein (SATB) 1 has been proposed to act as a determinant for the acquisition of metastatic activity by controlling expression of a specific set of genes that promote metastatic activity. Here we found that SATB1 expression is upregulated in multidrug-resistant breast cancer cells that exhibit higher invasive potential than the parental cells. Apart from accelerating metastasis and inducing epithelial[ndash]mesenchymal transition, SATB1 was demonstrated to confer resistance to both P-glycoprotein-related and P-glycoprotein-non-related drugs on MCF7 cells, which was accompanied by decreasin...
Source: Cancer Science - October 27, 2009 Category: Cancer & Oncology Authors: Qing-Quan Li, Zhong-Qing Chen, Jing-Da Xu, Xi-Xi Cao, Qi Chen, Xiu-Ping Liu, Zu-De Xu Source Type: journals

Potential for therapeutic targeting of tumor stem cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Recent developments in isolation and characterization of tumor stem cells (TSCs) have opened new possibilities for developing TSC-targeted therapies. Extensive efforts have been made to ascertain markers of TSCs, including cell surface, enzymatic, gene expression profile, and functional markers. These markers and the technologies used to identify and isolate TSCs are discussed in this review. TSC characteristics, such as quiescence, multidrug resistance, enhanced DNA repair ability, and anti-apoptotic mechanisms, and various features of the in vivo niche, which may make them resistant to conventional therapy, are also disc...
Source: Cancer Science - October 22, 2009 Category: Cancer & Oncology Authors: Vaibhav Saini, Robert H. Shoemaker Source Type: journals

Rapamycin inhibits lung metastasis of B16 melanoma cells through down-regulating alphav integrin expression and up-regulating apoptosis signalingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Currently available data indicate the potential application of rapamycin and its analogues in the clinic as anticancer therapeutic agents through inhibiting tumor cell growth and tumor angiogenesis. However, whether rapamycin can directly suppress tumor metastasis remains unclear. In the present study, we demonstrated that rapamycin treatment results in reduced formation of metastatic nodules in the lung by B16 cells. This is due to two mechanisms. First, the expression of [alpha]v integrin is down-regulated by rapamycin treatment, and subsequently, the phosphorylation of focal adhesion kinase (FAK) is reduced. Second, rap...
Source: Cancer Science - October 22, 2009 Category: Cancer & Oncology Authors: Zhuoshun Yang, Zhang Lei, Bo Li, Yu Zhou, Gui-Mei Zhang, Zuo-Hua Feng, Biao Zhang, Guan-Xin Shen, Bo Huang Source Type: journals

Mature acinar cells are refractory to carcinoma development by targeted activation of Ras oncogene in adult ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pancreatic ductal adenocarcinoma (PDA) is one of the most debilitating malignancies in humans. A thorough understanding of the cytogenesis of this disease will aid in establishing successful treatments. We have developed an animal model which uses adult HrasG12V and KrasG12V transgenic rats in which oncogene expression is regulated by the Cre/loxP system and neoplastic lesions are induced by injection of adenovirus-expressing Cre recombinase. When adenovirus with Cre recombinase under the control of the CMV enhancer/chicken [beta]-actin (CAG) promoter (Ad-CAG-Cre) is injected into the pancreatic duct of these animals, panc...
Source: Cancer Science - October 22, 2009 Category: Cancer & Oncology Authors: Hajime Tanaka, Katsumi Fukamachi, Mitsuru Futakuchi, David B. Alexander, Ne Long, Shojiro Tamamushi, Kohtaro Minami, Susumu Seino, Hirotaka Ohara, Takashi Joh, Hiroyuki Tsuda Source Type: journals

In vivo bioimaging tracks conditionally replicative adenoviral replication and provides an early indication of viral antitumor efficacyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In vivo monitoring of conditionally replicative adenovirus (CRAd) replication and assessing its correlation to CRAd biological effects are necessary for the clinical development of gene therapy. Noninvasive bioimaging is one current approach which can monitor in vivo CRAd replication and functional effect. Here we describe a novel cyclooxygenase-2 (Cox2) promoter-controlled CRAd that was modified to contain firefly luciferase in its E3 region; this modification permitted serial bioluminescence imaging of viral replication in vitro and in vivo. In vitro luciferase expression correlated with viral replication and cytolytic e...
Source: Cancer Science - October 20, 2009 Category: Cancer & Oncology Authors: Julia Davydova, Tatyana Gavrikova, Eric J. Brown, Xianghua Luo, David T. Curiel, Selwyn M. Vickers, Masato Yamamoto Source Type: journals

LAPTM4B-35, a novel tetratransmembrane protein and its PPRP motif play critical roles in proliferation and metastatic potential of hepatocellular carcinoma cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lysosomal protein transmembrane 4 beta (LAPTM4B) was originally identified as a hepatocellular carcinoma (HCC)-associated gene. This gene and its protein product LAPTM4B-35, are both overexpressed in a variety of human cancers. However, its specific role in cell transformation and malignancy has remained elusive. In the present study we investigated the effects of LAPTM4B-35 overexpression on the malignant phenotypic features in the HLE cell line. Our data show that overexpression of LAPTM4B-35 promotes cell proliferation, exogenous growth-stimulating factor-independent and anchorage-independent growth, and enhances metast...
Source: Cancer Science - October 18, 2009 Category: Cancer & Oncology Authors: Xinrong Liu, Fuxia Xiong, Xuanhui Wei, Hua Yang, Rouli Zhou Source Type: journals

Phase I study of TLR9 agonist PF-3512676 in combination with carboplatin and paclitaxel in patients with advanced non-small-cell lung cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This phase I, open-label study investigated the Toll-like receptor 9 agonist, PF-3512676, in combination with carboplatin and paclitaxel in Japanese patients with advanced, non-small-cell lung cancer (NSCLC). Patients (n = 12) with treatment-naive stage IIIB or IV NSCLC received single-agent PF-3512676 subcutaneously once during the first 7 days (monotherapy phase) in three escalating dose levels (0.1, 0.2, and 0.4 mg/kg) followed by a combination phase during which patients received 0.1 or 0.2 mg/kg PF-3512676 subcutaneously on days 8 and 15 of each 3-week cycle of carboplatin (area under the curve, 6 mg × min/mL) and pa...
Source: Cancer Science - October 15, 2009 Category: Cancer & Oncology Authors: Kazuhiko Yamada, Masao Nakao, Chikara Fukuyama, Hiroshi Nokihara, Noboru Yamamoto, Ikuo Sekine, Hideo Kunitoh, Yuichiro Ohe, Emiko Ohki, Junichi Hashimoto, Tomohide Tamura Source Type: journals

Dietary supplementation with branched-chain amino acids suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, oral BCAA supplementation improves insulin resistance and prevents the development of liver tumorigenesis in obese and diabetic mice. (Cancer Sci 2009) (Source: Cancer Science)
Source: Cancer Science - October 15, 2009 Category: Cancer & Oncology Authors: Junpei Iwasa, Masahito Shimizu, Makoto Shiraki, Yohei Shirakami, Hiroyasu Sakai, Yoichi Terakura, Koji Takai, Hisashi Tsurumi, Takuji Tanaka, Hisataka Moriwaki Source Type: journals

Fibroblast growth factor receptor 3 mutation in voided urine is a useful diagnostic marker and significant indicator of tumor recurrence in non-muscle invasive bladder cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The fibroblast growth factor receptor (FGFR)-3 gene encodes a receptor tyrosine kinase that is frequently mutated in non-muscle invasive bladder cancer (NMIBC). A sensitive and quantitative assay using peptide nucleic acid-mediated real-time PCR was developed for detecting FGFR3 mutations in the urine samples and evaluated as a molecular marker for detecting intravesical recurrence of NMIBC in patients undergoing transurethral resection of bladder tumor. FGFR3 mutation was examined in tumor tissues and serially taken pre- and postoperative urine sediments in 45 NMIBC patients with a median follow up of 32 months. FGFR3 mut...
Source: Cancer Science - October 14, 2009 Category: Cancer & Oncology Authors: Makito Miyake, Kokichi Sugano, Hitomi Sugino, Kazuho Imai, Eri Matsumoto, Koshi Maeda, Shinich Fukuzono, Hiroki Ichikawa, Kiyotaka Kawashima, Kaoru Hirabayashi, Tetsuro Kodama, Hiroyuki Fujimoto, Tadao Kakizoe, Yae Kanai, Kiyohide Fujimoto, Yoshihiko Hira Source Type: journals

E7050: A dual c-Met and VEGFR-2 tyrosine kinase inhibitor promotes tumor regression and prolongs survival in mouse xenograft modelsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
c-Met is the cellular receptor for hepatocyte growth factor (HGF) and is known to be dysregulated in various types of human cancers. Activation of the HGF/c-Met pathway causes tumor progression, invasion, and metastasis. Vascular endothelial growth factor (VEGF) is also known as a key molecule in tumor progression through the induction of tumor angiogenesis. Because of their key roles in tumor progression, these pathways provide attractive targets for therapeutic intervention. We have generated a novel, orally active, small molecule compound, E7050, which inhibits both c-Met and vascular endothelial growth factor receptor ...
Source: Cancer Science - October 13, 2009 Category: Cancer & Oncology Authors: Takayuki Nakagawa, Osamu Tohyama, Atsumi Yamaguchi, Tomohiro Matsushima, Keiko Takahashi, Setsuo Funasaka, Shuji Shirotori, Makoto Asada, Hiroshi Obaishi Source Type: journals

Vitamin E succinate induced apoptosis and enhanced chemosensitivity to paclitaxel in human bladder cancer cells in vitro and in vivoEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
There have been several studies on the antitumor activities of vitamin E succinate ([alpha]-TOS) as complementary and alternative medicine. In the present study, we investigated the cytotoxic effect of [alpha]-TOS and the enhancement of chemosensitivity to paclitaxel by [alpha]-TOS in bladder cancer. KU-19-19 and 5637 bladder cancer cell lines were cultured in [alpha]-TOS and/or paclitaxel in vitro. Cell viability, flow cytometric analysis, and nuclear factor-kappa B (NF-[kappa]B) activity were analyzed. For in vivo therapeutic experiments, pre-established KU-19-19 tumors were treated with [alpha]-TOS and/or paclitaxel. In...
Source: Cancer Science - October 12, 2009 Category: Cancer & Oncology Authors: Kunimitsu Kanai, Eiji Kikuchi, Shuji Mikami, Eriko Suzuki, Yasumitsu Uchida, Kiichiro Kodaira, Akira Miyajima, Takashi Ohigashi, Jun Nakashima, Mototsugu Oya Source Type: journals

XAF1 as a prognostic biomarker and therapeutic target in pancreatic cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
XAF1 (X chromosome-linked inhibitor of apoptosis [XIAP]-associated factor 1) is a novel XIAP modulator that negatively regulates the anti-apoptotic effects of XIAP and sensitizes cells to other cell death triggers. It has been reported to be downregulated in a variety of human cancer cell lines. However, the role of XAF1 in pancreatic carcinogenesis remains unclear. In the present study, we investigated the prognostic values of XAF1 expression and its regulation in cancer cell growth and apoptosis both in vitro and in vivo. From the immunohistochemistry staining of tissue microarray, 40 of 89 (44.9%) pancreatic specimens s...
Source: Cancer Science - October 12, 2009 Category: Cancer & Oncology Authors: Jia Huang, Wei-yan Yao, Qi Zhu, Shui-ping Tu, Fei Yuan, Hua-feng Wang, Yong-ping Zhang, Yao-zong Yuan Source Type: journals

Histological type of Thorotrast-induced liver tumors associated with the translocation of deposited radionuclidesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Exposure to internally deposited radionuclides is known to induce malignant tumors of various histological types. Thorotrast, a colloidal suspension of radioactive Thorium dioxide (232ThO2) that emits alpha-particles, was used as a radiographic contrast during World War II. Thorotrast is known to induce liver tumors, particularly intrahepatic cholangiocarcinoma (ICC) and angiosarcoma (AS), decades after injection. Therefore, patients injected with Thorotrast comprise a suitable study group to understand biological effects of internal ionizing radiation injury. Autoradiography and X-ray fluorescence spectrometry (XRF) were ...
Source: Cancer Science - October 12, 2009 Category: Cancer & Oncology Authors: Yoichiro Yamamoto, Junichi Chikawa, Yoshinobu Uegaki, Nobuteru Usuda, Yoshikazu Kuwahara, Manabu Fukumoto Source Type: journals

LIM domain-containing adaptor, leupaxin, localizes in focal adhesion and suppresses the integrin-induced tyrosine phosphorylation of paxillinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Focal adhesion (FA) consists of multiple cellular proteins including paxillin and serves as a center for adhesion-mediated signaling. The assembly and disassembly of FAs is regulated by locally produced intracellular signals, and tyrosine phosphorylation of paxillin has been implicated in this process. A Lin-11 Isl-1 Mec-3 (LIM) domain-containing adaptor protein, leupaxin, a member of the paxillin family, is expressed in leukocytes as well as in certain cancer cells, and shares overall structural characteristics with paxillin. However, it remains unknown whether leupaxin and paxillin cooperate with or antagonize each other...
Source: Cancer Science - October 12, 2009 Category: Cancer & Oncology Authors: Toshiyuki Tanaka, Kazumasa Moriwaki, Shinsuke Murata, Masayuki Miyasaka Source Type: journals

APC promoter hypermethylation is an early event in endometrial tumorigenesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of the current study was to investigate the role of promoter methylation of adenomatous polyposis coli (APC) and epithelial cadherin (E-cadherin) genes in endometrial tumorigenesis. The methylation status of both genes was investigated in 43 cases of normal endometrium, 21 simple hyperplasia, 17 atypical hyperplasia, and 86 endometrial carcinoma (EC). Additionally, the methylation pattern of both genes was analyzed in 24 primary ECs and their corresponding metastases. DNA methylation of the APC gene increased from atypical hyperplasia (23.5%) to endometrial carcinoma, reaching its highest level of 77.4% in early st...
Source: Cancer Science - October 12, 2009 Category: Cancer & Oncology Authors: Atanas Ignatov, Joachim Bischoff, Tanja Ignatov, Christa Schwarzenau, Thomas Krebs, Doerthe Kuester, Serban D. Costa, Albert Roessner, Andrzej Semczuk, Regine Schneider-Stock Source Type: journals

Increased chemoresistance induced by inhibition of HIF-prolyl-hydroxylase domain enzymesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The hypoxia-inducible factor (HIF) is the master regulator for oxygen-dependent gene expression. The HIF signal transduction pathway can be manipulated by inhibiting the activity of the HIF[alpha]-regulating prolyl-4-hydroxylase domain (PHD) enzymes. The consequence of inhibiting the PHD activity for chemoresistance was studied. Inhibiting the PHD activity with the 2-oxoglutarate analog dimethyloxaloylglycine (DMOG) results in increased chemoresistance towards etoposide but not carboplatin in HeLa cells. Evidence for an etoposide-specific resistance, which develops as a consequence of inhibiting the PHD activity, was furth...
Source: Cancer Science - October 11, 2009 Category: Cancer & Oncology Authors: Nils Brökers, Sinja Le-Huu, Sabine Vogel, Yohannes Hagos, Dörthe M. Katschinski, Malte Kleinschmidt Source Type: journals

Reduction of 15-hydroxyprostaglandin dehydrogenase expression is an independent predictor of poor survival associated with enhanced cell proliferation in gastric adenocarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Prostaglandin (PG) E2 promotes gastrointestinal carcinogenesis and tumor progression. We determined the correlations between pattern of expression of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a catabolic enzyme for biological inactivation of PGE2, in gastric adenocarcinoma and various clinicopathological factors and patient outcome in an attempt to elucidate its biological significance. In 35 of 71 cases of gastric adenocarcinoma, expression of 15-PGDH protein was reduced in tumor tissues. Multivariate analysis revealed reduction of 15-PGDH expression to be an independent predictor of poor survival. The proportion o...
Source: Cancer Science - October 10, 2009 Category: Cancer & Oncology Authors: Hiroshi Tatsuwaki, Tetsuya Tanigawa, Toshio Watanabe, Hirohisa Machida, Hirotoshi Okazaki, Hirokazu Yamagami, Masatsugu Shiba, Kenji Watanabe, Kazunari Tominaga, Yasuhiro Fujiwara, Nobuhide Oshitani, Kazuya Muguruma, Tetsuji Sawada, Kosei Hirakawa, Kazuhi Source Type: journals

Alpha-eleostearic acid suppresses proliferation of MCF-7 breast cancer cells via activation of PPARγ and inhibition of ERK 1 / 2Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Alpha-eleostearic acid ([alpha]-ESA) is known to suppress the growth in cancer cells although its underlying molecular mechanisms have not been fully elucidated. The present study was designed to elucidate and evaluate the anticancer mechanism of [alpha]-ESA on MCF-7 breast cancer cells. Also, an attempt was made to better understand the anticancer mechanism by which [alpha]-ESA activated PPAR[gamma] and attenuated the ERK1/2 MAPK phosphorylation state. The MCF-7 breast cancer cell-line and nontumorigenic MCF-10A human mammary epithelial cells were treated with [alpha]-ESA and compared with negative control (without treatm...
Source: Cancer Science - October 10, 2009 Category: Cancer & Oncology Authors: Hyun-Seuk Moon, Ding-Ding Guo, Hong-Gu Lee, Yun-Jaie Choi, Jae-Seong Kang, Kyungmin Jo, Jung-Min Eom, Cheol-Heui Yun, Chong-Su Cho Source Type: journals

Body iron store as a predictor of oxidative DNA damage in healthy men and womenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined the association between serum ferritin concentrations and levels of urinary 8-hydroxydeoxyguanosine (8-OHdG), a biomarker of systemic oxidative DNA damage and repair, in 528 Japanese men and women aged 21[ndash]67 years. Men had much higher ferritin levels than in women, and the levels were significantly greater in women aged 50 years or older than in women aged less than 50 years. Urinary 8-OHdG concentrations were significantly and positively associated with serum ferritin levels in all the subgroups. The Spearman rank correlation coefficients were 0.47, 0.76, and 0.73 for men overall, women aged less than 50...
Source: Cancer Science - October 10, 2009 Category: Cancer & Oncology Authors: Ai Hori, Tetsuya Mizoue, Hiroshi Kasai, Kazuaki Kawai, Yumi Matsushita, Akiko Nanri, Masao Sato, Masanori Ohta Source Type: journals

PC-407, a celecoxib derivative, inhibited the growth of colorectal tumor in vitro and in vivoEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aimed to observe the growth-inhibitory effect of PC-407 (4-[5-naphthyl-3-(trifluoromethyl)-1H-pyrazol-1-yl] benzenesulfonamide), a celecoxib derivative synthesized in our lab, in human colorectal cancer cells and a colitis-associated colorectal cancer (CACC) model, and investigate the relative molecular mechanisms. SW-1116 (expressing a high level of cyclooxygenase-2 [COX-2]), HT-29 (expressing a moderate level of COX-2), and SW-480 (no expression of COX-2) cell lines were exposed to different concentrations of celecoxib (0[ndash]100 [mu]mol/L) or PC-407 (0[ndash]100 [mu]mol/L). Then, COX-2 levels were assessed ...
Source: Cancer Science - October 8, 2009 Category: Cancer & Oncology Authors: Yuhua Li, Yinbo Niu, Huanjie Wu, Bangle Zhang, Yang Sun, Haitao Huang, Qian Li, Lei Fan, Li Liu, Qibing Mei Source Type: journals

l-Type amino acid transporter 1 inhibitors inhibit tumor cell growthEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Most tumor cell membranes overexpress l-type amino acid transporter 1, while normal cell membranes contain l-type amino acid transporter 2; both are Na+-independent amino acid transporters. Therefore, compounds that selectively inhibit l-type amino acid transporter 1 offer researchers with a novel cancer molecular target. Synthetic chemistry efforts and in vitro screening have produced a variety of novel compounds possessing high in vitrol-type amino acid transporter 1 selectivity; KYT-0353 was one such compound. The present studies illustrate that KYT-0353 inhibited 14C-leucine uptake and cell growth in human colon cancer...
Source: Cancer Science - October 8, 2009 Category: Cancer & Oncology Authors: Koji Oda, Noriko Hosoda, Hiroshi Endo, Kunio Saito, Kenji Tsujihara, Michio Yamamura, Takeshi Sakata, Naohiko Anzai, Michael F. Wempe, Yoshikatsu Kanai, Hitoshi Endou Source Type: journals

Changes in microRNA expression levels correlate with clinicopathological features and prognoses in endometrial serous adenocarcinomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aimed to determine the expression profiles of microRNAs (miRNAs) in endometrial serous adenocarcinoma and to examine the association between miRNA expression and clinical outcomes. Twenty-one patients diagnosed with endometrial serous adenocarcinoma between January 2001 and December 2006 were enrolled. miRNA expression profiles were examined using miRNA microarray and qRT-PCR. miRNA expression levels were correlated with clinicopathological variables and survival rates. A total of 120 miRNAs were differentially expressed in endometrial serous adenocarcinoma compared to normal endometria. Of these, 54 miRNAs were...
Source: Cancer Science - October 8, 2009 Category: Cancer & Oncology Authors: Eri Hiroki, Jun-ichi Akahira, Fumihiko Suzuki, Satoru Nagase, Kiyoshi Ito, Takashi Suzuki, Hironobu Sasano, Nobuo Yaegashi Source Type: journals

Independent and cooperative roles of tumor necrosis factor-α, nuclear factor-κB, and bone morphogenetic protein-2 in regulation of metastasis and osteomimicry of prostate cancer cells and differentiation and mineralization of MC3T3-E1 osteoblast-like cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The molecular mechanisms involved in prostate cancer (PC) metastasis and bone remodeling are poorly understood. We recently reported that phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) mediates transcriptional regulation and activation of bone morphogenetic protein (BMP)-2 signaling by nuclear factor (NF)-[kappa]B in bone metastatic prostate cancer cells. In the present study, we demonstrate that NF-[kappa]B, whether activated by recombinant human tumor necrosis factor (TNF)-[alpha] or by ectopic expression of the p65 subunit, is involved in extracellular matrix adhesion and invasion of osteotropic PC-3 and C4-2B,...
Source: Cancer Science - October 7, 2009 Category: Cancer & Oncology Authors: Tisheeka R. Graham, Krishna C. Agrawal, Asim B. Abdel-Mageed Source Type: journals

Recombinant adenovirus encoding vasohibin prevents tumor angiogenesis and inhibits tumor growthEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Numerous lines of evidence have shown that angiogenesis plays a pivotal role in the development of tumors. Therefore anti-angiogenesis therapy represents a potentially promising approach to cancer therapy. Recently, a new inhibitor called vasohibin was discovered to operate as an intrinsic and highly specific feedback inhibitor in the process of angiogenesis. However, to date, reports on the antitumor and anti-angiogenic properties of vasohibin have been very limited. To explore the potential of vasohibin as an anti-angiogenesis therapeutic, we constructed a recombinant adenovirus encoding vasohibin. Our data showed that t...
Source: Cancer Science - October 6, 2009 Category: Cancer & Oncology Authors: Dajiang Li, Kun Zhou, Shuguang Wang, Zhong Shi, Zhao Yang Source Type: journals

Histone deacetylase inhibitor (SAHA) and repression of EZH2 synergistically inhibit proliferation of gallbladder carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, this study suggests a possible mechanism by which carcinoma cells but not normal cells are sensitive to SAHA and indicates the efficacy of this new anticancer agent in combination with EZH2 repression in gallbladder carcinoma. (Cancer Sci 2009) (Source: Cancer Science)
Source: Cancer Science - October 6, 2009 Category: Cancer & Oncology Authors: Junpei Yamaguchi, Motoko Sasaki, Yasunori Sato, Keita Itatsu, Kenichi Harada, Yoh Zen, Hiroko Ikeda, Yuji Nimura, Masato Nagino, Yasuni Nakanuma Source Type: journals

Role of syndecan-1 (CD138) in cell survival of human urothelial carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, syndecan-1 might contribute to urothelial carcinoma cell survival and progression; therefore, this molecule could be a new therapeutic target in human urinary bladder cancer. (Cancer Sci 2009) (Source: Cancer Science)
Source: Cancer Science - October 6, 2009 Category: Cancer & Oncology Authors: Keiji Shimada, Mitsutoshi Nakamura, Marco A. De Velasco, Motoyoshi Tanaka, Yukiteru Ouji, Makito Miyake, Kiyohide Fujimoto, Kazuya Hirao, Noboru Konishi Source Type: journals

Effects of Src inhibitors on cell growth and epidermal growth factor receptor and MET signaling in gefitinib-resistant non-small cell lung cancer cells with acquired MET amplificationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The efficacy of epidermal growth factor receptor (EGFR)[ndash]tyrosine kinase inhibitors such as gefitinib and erlotinib in non-small cell lung cancer (NSCLC) is often limited by the emergence of drug resistance conferred either by a secondary T790M mutation of EGFR or by acquired amplification of the MET gene. We now show that the extent of activation of the tyrosine kinase Src is markedly increased in gefitinib-resistant NSCLC (HCC827 GR) cells with MET amplification compared with that in the gefitinib-sensitive parental (HCC827) cells. In contrast, the extent of Src activation did not differ between gefitinib-resistant ...
Source: Cancer Science - October 4, 2009 Category: Cancer & Oncology Authors: Takeshi Yoshida, Isamu Okamoto, Wataru Okamoto, Erina Hatashita, Yuki Yamada, Kiyoko Kuwata, Kazuto Nishio, Masahiro Fukuoka, Pasi A. Jänne, Kazuhiko Nakagawa Source Type: journals

The expression of dipeptidyl peptidase IV (DPPIV/CD26) is associated with enhanced chemosensitivity to paclitaxel in epithelial ovarian carcinoma cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dipeptidyl peptidase IV (DPPIV/CD26) is a multifunctional cell surface aminopeptidase that is widely expressed in different cell types. Recent studies have suggested that DPPIV plays an important role in tumor progression in several human malignancies. In the current study, we investigated the role of DPPIV in paclitaxel resistance in epithelial ovarian carcinoma (EOC) cells. We first examined the correlation between expression levels of DPPIV and sensitivity to paclitaxel in various EOC cell lines. Subsequently, to clarify the cellular functions of DPPIV, we investigated the role of this molecule in the sensitivity of EOC...
Source: Cancer Science - October 3, 2009 Category: Cancer & Oncology Authors: Hiroaki Kajiyama, Kiyosumi Shibata, Kazuhiko Ino, Shigehiko Mizutani, Akihiro Nawa, Fumitaka Kikkawa Source Type: journals

Steroid and xenobiotic receptor in human esophageal squamous cell carcinoma: A potent prognostic factorEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Steroid and xenobiotic receptor (SXR) is a nuclear receptor activated by diverse exogenous and endogenous compounds and has been demonstrated to play a pivotal role in detoxification through its regulation of various metabolizing enzymes and transporters. Recent studies also demonstrated the potential roles of SXR in the regulation of apoptosis and inflammation in various carcinoma cells, but the status of SXR in human esophageal squamous cell carcinoma (ESCC) has not been examined. Therefore, in this study, we performed immunohistochemical and quantitative RT-PCR evaluations in human ESCC in order to clarify its biologica...
Source: Cancer Science - October 3, 2009 Category: Cancer & Oncology Authors: Daisuke Takeyama, Yasuhiro Miki, Fumiyoshi Fujishima, Takashi Suzuki, Jun-ichi Akahira, Shuko Hata, Go Miyata, Susumu Satomi, Hironobu Sasano Source Type: journals

Expression of thioredoxin during progression of hamster and human cholangiocarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Thioredoxin (Trx) is a multifunctional redox protein that has growth-promoting and anti-apoptotic effects on cells and protects cells from endogenous and exogenous free radicals. Recently, altered expression of Trx has been reported in various cancers. In the present study, we investigated altered expression of Trx at the precancerous and carcinogenic phases during cholangiocarcinogenesis in a hamster cholangiocarcinoma (ChC) model, using semiquantitative immunohistochemical and Western blot analyses. Moreover, to determine if the results correlated well with those in human ChCs, we carried out a comparative immunohistoche...
Source: Cancer Science - October 1, 2009 Category: Cancer & Oncology Authors: Byung-Il Yoon, Yeong-Hun Kim, Jung-Yeon Yi, Min-Soo Kang, Ja-June Jang, Kyoung-Hwan Joo, Yongbaek Kim, J. McHugh Law, Dae-Yong Kim Source Type: journals

Gene silencing of glypican-3 in clear cell carcinoma of the ovary renders it more sensitive to the apoptotic agent paclitaxel in vitro and in vivoEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report here that GPC3 was expressed in clear cell carcinoma of the ovary, and not in other carcinomas. To evaluate the phenotype and potential preclinical relevance, we generated an ovarian cancer cell line stably transfected with plasmids encompassing shRNA targeting GPC3. We show that the clear cell carcinoma cell line with silenced GPC3 expression (GPC3 [[minus]]) was more sensitive to paclitaxel than GPC3 (+) cells. In addition, the GPC3 silencing induced sensitization to paclitaxel was associated with the activation of an apoptosis pathway, as shown by flow cytometry. Moreover, we investigated the effect of GPC3 on...
Source: Cancer Science - October 1, 2009 Category: Cancer & Oncology Authors: Tomokazu Umezu, Kiyosumi Shibata, Maiko Shimaoka, Hiroaki Kajiyama, Eiko Yamamoto, Kazuhiko Ino, Akihiro Nawa, Takeshi Senga, Fumitaka Kikkawa Source Type: journals

Carcinogenic potential of alizarin and rubiadin, components of madder color, in a rat medium-term multi-organ bioassayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Madder color (MC), a food coloring extracted from roots of Rubia tinctorum L., has been proven to exert carcinogenicity in the rat kidney and liver. Furthermore, it induces DNA adducts in the kidney, liver, and colon. MC is in fact composed of anthraquinones such as lucidin-3-O-primeveroside and alizarin. To clarify which of these might be responsible for the carcinogenicity, a rat medium-term multi-organ carcinogenesis bioassay was performed focusing on the kidney, liver, and colon. Male 6-week-old F344 rats after receiving five different carcinogens were fed a diet containing either 0.008% or 0.04% of alizarin or rubiadi...
Source: Cancer Science - September 30, 2009 Category: Cancer & Oncology Authors: Kaoru Inoue, Midori Yoshida, Miwa Takahashi, Hitoshi Fujimoto, Makoto Shibutani, Masao Hirose, Akiyoshi Nishikawa Source Type: journals

Oral delivery of tumor-targeting Salmonella exhibits promising therapeutic efficacy and low toxicityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Tumor-targeting bacteria have been developed as powerful anticancer agents. Salmonella typhimurium VNP20009, a representative tumor-targeting strain, has been systemically administered as a single-agent therapy at doses of 1 × 106 to 3 × 106 colony-forming unit (cfu)/mouse, or in combination with other antitumor agents at doses of 1 × 104 to 2 × 105 cfu/mouse. Recently, we reported that oral delivery of VNP20009 at the dose of 1 × 109 cfu/mouse induced significant anticancer effects comparable to that induced by systemic administration of this strain at 1 × 104 cfu/mouse. To further address the efficacy and safety of...
Source: Cancer Science - September 29, 2009 Category: Cancer & Oncology Authors: Guo Chen, Dong-Ping Wei, Li-Jun Jia, Bo Tang, Luan Shu, Kui Zhang, Yun Xu, Jing Gao, Xiao-Feng Huang, Wen-Hui Jiang, Qing-Gang Hu, Yan Huang, Qiang Wu, Zhi-Hua Sun, Jian-Fa Zhang, Zi-Chun Hua Source Type: journals

Molecular mechanism underlying the synergistic interaction between trifluorothymidine and the epidermal growth factor receptor inhibitor erlotinib in human colorectal cancer cell linesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study investigated molecular mechanisms underlying the cytotoxic actions of the combination of an EGFR[minus]tyrosine kinase inhibitor with TFT in colorectal cancer cells Caco2, WiDR, Lovo92, and Colo320. Drug interactions were examined by the sulforhodamine B assay and subsequent combination index (CI) analyses, cell cycle effects by FACS analysis of propidium iodide stained cells, Akt, MAPK and EGFR phosphorylation and expression levels by Western blotting and TS activity by the TS in situ assay. All combination schedules were synergistic in wt-EGFR expressing (but with mutated downstream pathways) WiDR and Lovo92 (...
Source: Cancer Science - September 29, 2009 Category: Cancer & Oncology Authors: Irene V. Bijnsdorp, Frank A. E. Kruyt, Masakazu Fukushima, Kees Smid, Shanti Gokoel, Godefridus J. Peters Source Type: journals

Modulation of innate immunity system by Epstein–Barr virus-encoded non-coding RNA and oncogenesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Epstein[ndash]Barr virus (EBV)-encoded small RNAs (EBERs) are polyA[ndash], non-coding RNAs that are expressed abundantly in all forms of cells latently infected with EBV. EBERs (EBER1 and EBER2) contribute to the clonal proliferation of EBV-negative Burkitt's lymphoma (BL) cells in soft agar, tumorigenicity in SCID mice, up-regulation of the bcl-2 oncoprotein, resistance to apoptosis, and maintenance of malignant phenotypes in BL cells. EBERs induce the expression of interleukin (IL)-10 in BL cells, insulin-like growth factor 1 (IGF-I) in gastric and nasopharyngeal carcinoma cells, IL-9 in T cells, and IL-6 in lymphoblast...
Source: Cancer Science - September 29, 2009 Category: Cancer & Oncology Authors: Mrinal Samanta, Kenzo Takada Source Type: journals

Soy product and isoflavone intake and breast cancer risk defined by hormone receptor statusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study suggests that consumption of soy food, soy isoflavone, is inversely associated with the risk of breast cancer. The protective effects of soy did not seem to differ by ER and PR breast cancer status. (Cancer Sci 2009) (Source: Cancer Science)
Source: Cancer Science - September 28, 2009 Category: Cancer & Oncology Authors: Caixia Zhang, Suzanne C. Ho, Fangyu Lin, Shouzhen Cheng, Jianhua Fu, Yuming Chen Source Type: journals

Clusterin as a predictor for chemoradiotherapy sensitivity and patient survival in esophageal squamous cell carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clusterin (CLU) is frequently overexpressed and correlates closely with chemotherapy and radiotherapy resistance and poor prognosis in many human cancers. However, the significance of CLU expression in chemoradiotherapy (CRT) sensitivity and its effect on the prognosis of esophageal squamous cell carcinoma (ESCC) are still unknown. In the present study, we used the methods of immunohistochemistry and terminal deoxyuridine triphosphate nick-end labeling assay to examine the expression status of CLU and apoptotic index in 110 pretreated biopsy specimens of ESCC patients treated with definitive CRT. High expression of CLU was...
Source: Cancer Science - September 28, 2009 Category: Cancer & Oncology Authors: Li-Ru He, Meng-Zhong Liu, Bin-Kui Li, Hui-Lan Rao, Yi-Ji Liao, Lan-Jun Zhang, Xin-Yuan Guan, Yi-Xin Zeng, Dan Xie Source Type: journals

Current status of chemotherapy in risk-adapted management for metastatic testicular germ cell cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Today, approximately 80% of men with metastatic testicular cancer can be cured with chemotherapy combined with the appropriate surgery. The improved treatment outcome has led to the stratification of patients with metastatic disease by the consensus prognostic index; the International Germ Cell Cancer Consensus Group classification. Currently, the first-line chemotherapy with bleomycin, etoposide, and cisplatin (BEP) remains the standard management of metastatic testicular cancer. Three cycles of BEP for good-prognosis patients and four cycles of BEP for intermediate- and poor-prognosis patients are the standard first-line...
Source: Cancer Science - September 26, 2009 Category: Cancer & Oncology Authors: Koji Kawai, Hideyuki Akaza Source Type: journals

Identification of transforming activity of free fatty acid receptor 2 by retroviral expression screeningEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gallbladder cancer (GBC) is a highly fatal malignancy in humans. Genetic alterations in KRAS or TP53 as well as overexpression of ERBB2 have been shown to contribute to the development of certain types of GBC. However, many cases of GBC do not harbor such genetic changes, with other transforming events awaiting discovery. We here tried to identify novel cancer-promoting genes in GBC, with the use of a retroviral cDNA expression library. A retroviral cDNA expression library was constructed from a surgically resected clinical specimen of GBC, and was used to infect 3T3 fibroblasts in a focus formation assay. cDNA incorporate...
Source: Cancer Science - September 24, 2009 Category: Cancer & Oncology Authors: Hisashi Hatanaka, Mamiko Tsukui, Shuji Takada, Kentaro Kurashina, Young Lim Choi, Manabu Soda, Yoshihiro Yamashita, Hidenori Haruta, Toru Hamada, Toshihide Ueno, Kiichi Tamada, Yoshinori Hosoya, Naohiro Sata, Yoshikazu Yasuda, Hideo Nagai, Kentaro Sugano, Source Type: journals

Distinctive cell properties of B cells carrying the BCL2 translocation and their potential roles in the development of lymphoma of germinal center typeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The BCL2/IGH translocation is a hallmark of follicular lymphoma and germinal center B-cell type diffuse large B-cell lymphoma. Although a strong determinant of these histological subtypes, this translocation is insufficient by itself for lymphomagenesis, so that other genetic alterations are required. To clarify how the BCL2 translocation contributes to the development of specific lymphoma subtypes, we used chimeric mouse models and a bone marrow transplantation system to examine the biological features of BCL2-overexpressing B cells. These cells showed a cell-autonomous differentiation preference for follicular B cells. T...
Source: Cancer Science - September 23, 2009 Category: Cancer & Oncology Authors: Tomomi Sakai, Momoko Nishikori, Masaharu Tashima, Ryo Yamamoto, Toshio Kitawaki, Akifumi Takaori-Kondo, Takayo Suzuki, Shinobu Tsuzuki, Takashi Uchiyama Source Type: journals