Cancers, Vol. 16, Pages 1655: Real-World Treatment Patterns and Survival Outcomes for Patients with Non-Metastatic Non-Small-Cell Lung Cancer in Sweden: A Nationwide Registry Analysis from the I-O Optimise Initiative
aker
Gunnar Wagenius
Non-small-cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide, with ~40–50% of patients diagnosed with non-metastatic disease (stages IA–IIIC). The treatment landscape is evolving rapidly as immunotherapies and targeted therapy are introduced in the non-metastatic setting, creating a need to assess patient outcomes prior to their introduction. This real-world study using Swedish National Lung Cancer Registry data examined outcomes (overall survival (OS) and time to next treatment or death (TTNTD)) and treatment patterns for adults diagnosed ...
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: Gudrun N. Oskarsdottir Erik Lampa Anders Berglund Linda Rosengren Maria Ulvestad Miklos Boros Melinda J. Daumont Caroline Rault Gabrielle Emanuel C átia Leal Minouk J. Schoemaker Gunnar Wagenius Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1656: Gastric Inhibitory Polypeptide Receptor (GIPR) Overexpression Reduces the Tumorigenic Potential of Retinoblastoma Cells
e Dünker
Retinoblastoma (RB) is the most common malignant intraocular tumor in early childhood. Gene expression profiling revealed that the gastric inhibitory polypeptide receptor (GIPR) is upregulated following trefoil factor family peptide 1 (TFF1) overexpression in RB cells. In the study presented, we found this G protein-coupled transmembrane receptor to be co-expressed with TFF1, a new diagnostic and prognostic RB biomarker for advanced subtype 2 RBs. Functional analyses in two RB cell lines revealed a significant reduction in cell viability and growth and a concomitant increase in apoptosis following stable, len...
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: Andr é Haase Emily Alefeld Fatma Yalinci Dario Van Meenen Maike Anna Busch Nicole D ünker Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1657: Deregulation of New Cell Death Mechanisms in Leukemia
raglia
Rosaria Benedetti
Lucia Altucci
Vincenzo Carafa
Hematological malignancies are among the top five most frequent forms of cancer in developed countries worldwide. Although the new therapeutic approaches have improved the quality and the life expectancy of patients, the high rate of recurrence and drug resistance are the main issues for counteracting blood disorders. Chemotherapy-resistant leukemic clones activate molecular processes for biological survival, preventing the activation of regulated cell death pathways, leading to cancer progression. In the past decade, leukemia research has predominantly cente...
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: Gregorio Favale Federica Donnarumma Vincenza Capone Laura Della Torre Antonio Beato Daniela Carannante Giulia Verrilli Asmat Nawaz Francesco Grimaldi Maria Carla De Simone Nunzio Del Gaudio Wouter Leonard Megchelenbrink Michele Caraglia Rosaria Benedetti Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1658: Endoscopic Contrast-Enhanced Ultrasound and Fine-Needle Aspiration or Biopsy for the Diagnosis of Pancreatic Solid Lesions: A Systematic Review and Meta-Analysis
Conclusion: ECEUS-FNA and FNB do not appear superior to standard EUS-FNA and FNB for the diagnosis of pancreatic lesions. (Source: Cancers)
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: Giorgio Esposto Giuseppe Massimiani Linda Galasso Paolo Santini Raffaele Borriello Irene Mignini Maria Elena Ainora Alberto Nicoletti Lorenzo Zileri Dal Verme Antonio Gasbarrini Sergio Alfieri Giuseppe Quero Maria Assunta Zocco Tags: Systematic Review Source Type: research
Cancers, Vol. 16, Pages 1659: A Combined Cyto- and Histopathological Diagnostic Approach Reduces Time to Diagnosis and Time to Therapy in First Manifestation of Metastatic Spinal Disease: A Cohort Study
r
Viezens
Asemissen
Malignant spinal lesions (MSLs) are frequently the first manifestation of malignant disease. Spinal care, diagnostic evaluation, and the initiation of systemic therapy are crucial for outcomes in patients (pts) with advanced cancer. However, histopathology (HP) may be time consuming. The additional evaluation of spinal lesions using cytopathology (CP) has the potential to reduce the time to diagnosis (TTD) and time to therapy (TTT). CP and HP specimens from spinal lesions were evaluated in parallel in 61 pts (CP/HP group). Furthermore, 139 pts in whom only HP was performed were analyzed (HP gr...
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: Leonhardt Heuer Stangenberg Schroeder Schmidt Welker von Amsberg Strahl Kr üger Dreimann Bokemeyer Viezens Asemissen Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1662: The Causes and Consequences of DNA Damage and Chromosomal Instability Induced by Human Papillomavirus
Mehta
Cosper
High-risk human papillomaviruses (HPVs) are the main cause of cervical, oropharyngeal, and anogenital cancers, which are all treated with definitive chemoradiation therapy when locally advanced. HPV proteins are known to exploit the host DNA damage response to enable viral replication and the epithelial differentiation protocol. This has far-reaching consequences for the host genome, as the DNA damage response is critical for the maintenance of genomic stability. HPV+ cells therefore have increased DNA damage, leading to widespread genomic instability, a hallmark of cancer, which can contribute to tumo...
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: Jones Bryan McCunn Lantz Blalock Ojeda Mehta Cosper Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1660: Temporal Muscle Thickness Compared to Functional Scales as a Prognostic Parameter in Patients with Brain Metastases
ian F. Freyschlag
Metastases are the most frequent intracranial malignant tumors in adults. While Karnofsky Performance Status (KPS) and Clinical Frailty Scale (CFS) are known to have significant impact on overall survival (OS), temporal muscle thickness (TMT) has been postulated to be a promising new parameter to estimate prognosis. Patients who received a resection of one to three brain metastases in our institution were included. Temporal muscle thickness was measured in preoperative MRI scans according to a standardized protocol. In 199 patients, the mean TMT was 7.5 mm (95CI 7.3–7.7) and the mean OS ...
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: Julia Klingenschmid Aleksandrs Krigers Daniel Pinggera Johannes Kerschbaumer Nadine Pichler Victoria Sch ön Matthias Demetz Astrid E. Grams Claudius Thom é Christian F. Freyschlag Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1663: Outcomes and Adverse Events in Patients with Cancer after Diagnosis of Immunotherapy-Associated Diabetes Mellitus: A Retrospective Cohort Study
Quandt
Immune checkpoint inhibitor (CPI)-induced diabetes mellitus (CPI-DM) is a rare immune-related adverse event (irAE). Patients and providers fear that continuing CPIs puts patients at risk for additional irAEs and thus may discontinue therapy. Currently, there are little data to inform this decision. Therefore, this study aims to elucidate whether discontinuing CPIs after diagnosis of CPI-DM impacts the development of future irAEs and cancer outcomes such as progression and death. Patients who developed CPI-DM during cancer treatment at UCSF from 1 July 2015 to 5 July 2023 were analyzed for cancer outcomes and...
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: Duvalyan Brondfield Rushakoff Anderson Quandt Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1664: L-Glyceraldehyde Inhibits Neuroblastoma Cell Growth via a Multi-Modal Mechanism on Metabolism and Signaling
We describe a novel multi-modal mechanism by which the L-isomer of GA (L-GA) inhibits neuroblastoma cell growth. L-GA induces significant changes in the metabolic profile, promotes oxidative stress and hinders nucleotide biosynthesis. GC-MS and 13C-labeling was employed to measure the flow of carbon through glycolytic intermediates under L-GA treatment. It was found that L-GA is a potent inhibitor of glycolysis due to its proposed targeting of NAD(H)-dependent reactions. This results in growth inhibition, apoptosis and a redox crisis in neuroblastoma cells. It was confirmed that the redox mechanisms were modulated via L-GA...
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: Martin Forbes Richard Kempa Guido Mastrobuoni Liam Rayman Matthias Pietzke Safak Bayram Birte Arlt Annika Spruessel Hedwig E. Deubzer Stefan Kempa Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1661: Multilevel Social Determinants of Patient-Reported Outcomes in Young Survivors of Childhood Cancer
In this study, the social determinants of patient-reported outcomes (PROs) in young survivors of childhood cancer aged <18 years are researched. This cross-sectional study investigated social determinants associated with poor PROs among young childhood cancer survivors. We included 293 dyads of survivors receiving treatment at St. Jude Children’s Research Hospital who were <18 years of age during follow-up from 2017 to 2018 and their primary caregivers. Social determinants included family factors (caregiver-reported PROs, family dynamics) and county-level deprivation (socioeconomic statu...
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: Jin-ah Sim Madeline R. Horan Jaesung Choi Deo Kumar Srivastava Gregory T. Armstrong Kirsten K. Ness Melissa M. Hudson I-Chan Huang Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1665: Stereotactic Radiosurgery for Patients with Brain Metastases from Hepatopancreaticobiliary Cancers
Conclusions: Metastatic spread to the brain from HPB cancers occurs late in the course of the primary disease. In this study, all deceased patients ultimately died from primary disease progression. SRS is a non-invasive strategy that maximally preserves quality of life, and our results reported favorable outcomes compared to the existing literature. SRS should be considered as one of the primary management strategies for patients with brain metastatic spread from HPB cancer. (Source: Cancers)
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: Wei Srinivasan Patel Bednarz Flickinger Hadjipanayis Niranjan Lunsford Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1666: Hypomethylation of ATP1A1 Is Associated with Poor Prognosis and Cancer Progression in Triple-Negative Breast Cancer
Han
Park
Yoo
Park
: Dysregulated DNA methylation in cancer is critical in the transcription machinery associated with cancer progression. Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype, but no treatment targeting TNBC biomarkers has yet been developed. To identify specific DNA methylation patterns in TNBC, methyl-binding domain protein 2 (MBD) sequencing data were compared in TNBC and the three other major breast cancer subtypes. Integrated analysis of DNA methylation and gene expression identified a gene set showing a correlation between DNA methylation and gene expressi...
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: Kim Ko Kong Lee Chung Lim Son Oh Park Kim Lee Han Park Yoo Park Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1667: Identifying Candidate Gene Drivers Associated with Relapse in Pediatric T-Cell Acute Lymphoblastic Leukemia Using a Gene Co-Expression Network Approach
Jean-Francois Peyron
Pediatric T-cell Acute Lymphoblastic Leukemia (T-ALL) relapses are still associated with a dismal outcome, justifying the search for new therapeutic targets and relapse biomarkers. Using single-cell RNA sequencing (scRNAseq) data from three paired samples of pediatric T-ALL at diagnosis and relapse, we first conducted a high-dimensional weighted gene co-expression network analysis (hdWGCNA). This analysis highlighted several gene co-expression networks (GCNs) and identified relapse-associated hub genes, which are considered potential driver genes. Shared relapse-expressed genes were found to be re...
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: Anthony Kypraios Juba Bennour V éronique Imbert L éa David Julien Calvo Fran çoise Pflumio Rapha ël Bonnet Marie Couralet Virginie Magnone Kevin Lebrigand Pascal Barbry Pierre S. Rohrlich Jean-Francois Peyron Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1669: Quantitative Optical Redox Imaging of Melanoma Xenografts with Different Metastatic Potentials
Lin Z. Li
To develop imaging biomarkers for tumors aggressiveness, our previous optical redox imaging (ORI) studies of the reduced nicotinamide adenine dinucleotide (NADH) and oxidized flavoproteins (Fp, containing flavin adenine dinucleotide, i.e., FAD) in tumor xenografts of human melanoma associated the high optical redox ratio (ORR = Fp/(Fp + NADH)) and its heterogeneity to the high invasive/metastatic potential, without having reported quantitative results for NADH and Fp. Here, we implemented a calibration procedure to facilitate imaging the nominal concentrations of tissue NADH and Fp in the mouse xenografts of ...
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: April Peng He N. Xu Lily Moon Paul Zhang Lin Z. Li Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1668: Germline Genetic Mutations in Adult Patients with Sarcoma: Insight into the Middle East Genetic Landscape
dah
Abdel-Razeq
Data on germline mutations in soft tissue and bone sarcomas are scarce. We sought to identify the prevalence of germline mutations in adult sarcoma patients treated at a tertiary cancer center. Newly diagnosed patients were offered germline genetic testing via an 84-gene panel. The prevalence of pathogenic germline variants (PGVs) and their association with disease-, and patient- related factors are reported. A total of 87 patients were enrolled, the median age was 48 (19–78) years, and 47 (54%) were females. Gastrointestinal stromal tumors (n = 12, 13.8%), liposarcoma (n = 10, 11.5%), ...
Source: Cancers - April 25, 2024 Category: Cancer & Oncology Authors: Abu-Hijlih Sharaf Salah Bani Hani Alqaisieh Alzibdeh Ababneh Mahafdah Abdel-Razeq Tags: Article Source Type: research
