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Renin-Angiotensin System Suppression Mitigates Experimental Radiation PneumonitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Purpose: To find the mitigators of pneumonitis induced by moderate doses of thoracic radiation (10–15 Gy).Methods and Materials: Unanesthetized WAG/RijCmcr female rats received a single dose of X-irradiation (10, 12, or 15 Gy at 1.615 Gy/min) to the thorax. Captopril (an angiotensin-converting enzyme inhibitor) or losartan (an angiotensin receptor blocker) was administered in the drinking water after irradiation. Pulmonary structure and function were assessed after 8 weeks in randomly selected rats by evaluating the breathing rate, ex vivo vascular reactivity, and histopathologic findings. Survival analysis was undertake...
Source: International Journal of Radiation Oncology * Biology * Physics - November 19, 2009 Category: Radiology Authors: Swarajit N. Ghosh, Rong Zhang, Brian L. Fish, Vladimir A. Semenenko, X. Allen Li, John E. Moulder, Elizabeth R. Jacobs, Meetha Medhora Tags: Biology Contributions Source Type: journals

The Effect of Captopril on Progression of Retinopathy in Type 2 DiabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Diabetes Technology & Therapeutics Nov 2009, Vol. 11, No. 11: 711-715. (Source: Diabetes Technology)
Source: Diabetes Technology - November 11, 2009 Category: Endocrinology Tags: article Source Type: journals

Development and validation of an HPLC method for the simultaneous analysis of 23 selected drugs belonging to different therapeutic groups in human urine samples.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We have developed and validated a new and reliable gradient reversed-phase high-performance liquid chromatography (RP-HPLC) method with a diode array detector (DAD) for the simultaneous separation and determination of 23 frequently prescribed selected drugs belonging to different therapeutic groups in human urine samples. For the drugs listed below, this method of analysis for human urine was also successfully applied to determine urine concentrations of these drugs in samples from treated patients: enalapril (ENA), paracetamol (PAR), sotalol (SOT), dipyrone (DIP), vancomycin (VAN), captopril (CAP), fluconazole (FLU), ...
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - November 1, 2009 Category: Chemistry Authors: Baranowska I, Markowski P, Baranowski J Tags: Anal Sci Source Type: journals

Angiotensin II stimulates trafficking of NHE3, NaPi2 and associated proteins into the proximal tubule microvilli.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Angiotensin II (AngII) stimulates proximal tubule (PT) sodium and water reabsorption. We showed that treating rats acutely with the angiotensin converting enzyme inhibitor captopril decreases PT salt and water reabsorption and provokes rapid redistribution of the Na(+)/H(+) exchanger isoform 3 (NHE3), Na(+)/Pi co-transporter 2 (NaPi2) and associated proteins out of the microvilli. The aim of the present study was to determine whether acute AngII infusion increases the abundance of PT NHE3, NaPi2 and associated proteins in the microvilli available for reabsorbing NaCl. Male Sprague Dawley rats were infused with a dose o...
Source: American Journal of Physiology. Renal Physiology - October 28, 2009 Category: Physiology Authors: Riquier-Brison AD, Leong PK, Pihakaski-Maunsbach K, McDonough AA Tags: Am J Physiol Renal Physiol Source Type: journals

Solubility of Captopril in 2-Propanol, Acetone, Acetonitrile, Methyl Acetate, Ethyl Acetate, and Butyl AcetateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Journal of Chemical & Engineering Data, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Chemical and Engineering Data)
Source: Journal of Chemical and Engineering Data - October 27, 2009 Category: Chemistry Tags: article Source Type: journals

Clinical research Captopril and losartan modify mitogen-induced proliferative response and expression of some differentiation antigents on peripheral blood mononuclear cells in chronic uraemic patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our in vitro results seem to indicate that captopril and losartan interfere with immune cells and depress some functions of immune cells in chronic uremic patients and healthy subjects. It is very difficult at present to establish significance of these in vitro immunosuppresive effects of captopril and losartan reflects their in vivo action. Its significance for clinical implications necessitates further extensive studies. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)
Source: Articles of Archives of Medical Science - TERMEDIA publishing house - October 22, 2009 Category: Journals (General) Source Type: journals

CAPTOPRIL Tablet CAPTOPRIL (Captopril) Tablet [Apotex Corp.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Oct 21, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - October 21, 2009 Category: Drugs & Pharmacology Source Type: organizations

Captopril-enhanced renal scintigraphy in the diagnosis of pediatric hypertensionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Hypertension in childhood is no longer a rare condition mainly secondary to renal, or renovascular diseases, as a growing proportion of children are obese and hypertensive, with the phenotype of metabolic syndrome. Thus, we need to reconsider our practice in the examination of the hypertensive child and redefine the place of non-invasive methods for screening of renovascular hypertension, and specifically, to evaluate the value of captopril-enhanced renal scintigraphy at the two ends of the palette: the obese child with hypertension and the severely hypertensive prepubertal child. Renal artery steno...
Source: Pediatric Nephrology - October 20, 2009 Category: Urology & Nephrology Tags: Pediatric Nephrology Source Type: journals

Med Sci Monit 2009; 15(11):BR334-338 "Influence of selected angiotensin-converting enzyme inhibitors on alloxan-induced diabetic cataract in rabbits"Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: ACEIs delay diabetic cataractogenesis in an experimental animal model. The ACEI functional groups have different influences on the pattern and rate of lens opacity. (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 19, 2009 Category: Research Tags: Original article Source Type: journals

Pharmacodynamic interaction of captopril with garlic in isoproterenol-induced myocardial damage in ratEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
It is known that various preparations of garlic and angiotensin-converting enzyme (ACE) inhibitor such as captopril (CAP) have beneficial effects on the left ventricular function and cardiovascular events after myocardial infarction (MI) when used individually. There is no reported interaction between garlic homogenate (GH) and CAP during and after acute MI. Thus the purpose of the current study was to evaluate the possible pharmacodynamic interaction of GH with CAP on isoproterenol (ISO)-induced myocardial damage in rat. Female Wistar albino rats were treated with GH at three different doses of 125; 250 and 500 mg/kg oral...
Source: Phytotherapy Research - October 13, 2009 Category: Biochemistry Authors: Syed Mohammed Basheeruddin Asdaq, Mohammed Naseeruddin Inamdar Source Type: journals

Sardine Peptide with Angiotensin I-Converting Enzyme Inhibitory Activity Improves Glucose Tolerance in Stroke-Prone Spontaneously Hypertensive Rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An enzymatic hydrolysate of sardine protein (sardine peptide, SP) derived from sardine muscle possesses angiotensin I-converting enzyme (ACE) inhibitory activity. In the present study, we investigated the effect of SP on the blood glucose levels in stroke-prone spontaneously hypertensive rats (SHRSPs). Ten-week-old SHRSPs were assigned to three groups. The control group was given tap water for 4 weeks, while the experimental groups were given water containing SP (1 g/kg/d) or an ACE inhibitor, captopril (8 g/kg/d). Treatment with SP and captopril decreased ACE activity in the kidney, aorta, and mesentery. There were no...
Source: Bioscience, Biotechnology, and Biochemistry - October 6, 2009 Category: Biochemistry Authors: Otani L, Ninomiya T, Murakami M, Osajima K, Kato H, Murakami T Tags: Biosci Biotechnol Biochem Source Type: journals

Chemiluminescence spectra for the oxidation of sulphite in the presence of fluorescent and non-fluorescent enhancers.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The spectral distribution of chemiluminescence provides key evidence in the elucidation of the reaction mechanism and emitting species. We have collected chemiluminescence spectra for the oxidation of sodium sulphite and captopril in the presence of a range of fluorescent and non-fluorescent enhancers. This evidence was used to evaluate several previously proposed light-producing pathways, and revealed some new approaches to enhance the chemiluminescent oxidation of sulphite and thiol compounds. Chemiluminescence reactions between sulphite and permanganate produce two potential emitters: one derived from the oxidation ...
Source: Analytica Chimica Acta - October 1, 2009 Category: Chemistry Authors: Adcock JL, Francis PS, Barnett NW Tags: Anal Chim Acta Source Type: journals

Differences between99mTc-DTPA and99mTc-MAG3 captopril renographies in renovascular hypertensionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Captopril renography (CRS) with99mTc-DTPA and99mTc-MAG3 was performed on a 21-year-old woman with renovascular hypertension due to right renal artery stenosis caused by fibromuscular dysplasia. In the affected kidney, the renogram pattern was substantially changed with99mTc-DTPA and99mTc-MAG3 following the administration of captopril, and the quantitated renal uptake indicating individual renal function was significantly decreased in99mTc-DTPA and slightly decreased in99mTc-MAG3. In the contralateral normal kidney, the renogram showed some minor changes with both radioagents, while the quantitated re...
Source: Annals of Nuclear Medicine - September 30, 2009 Category: Radiology Tags: Annals of Nuclear Medicine Source Type: journals

Variable kidney position mimicking renal artery branch stenosis in a Tc-99m-DTPA captopril scintigraphyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Tc-99m-DTPA captopril scintigraphy was performed in a patient with suspected renovascular hypertension. Markedly impaired right renal function (Glomerular filtration rate (GFR) values for the right kidney = 14 ml/min, left kidney = 79 ml/min) was detected in the initial captopril study. Only lower pole activity of the right kidney was observed during the whole study. Since prior ultrasonographic examinations have shown bilateral normal kidney parenchyma, branch stenosis of the right upper pole was suspected. Besides significant function improvement in the following baseline study (GFR values for the...
Source: Annals of Nuclear Medicine - September 30, 2009 Category: Radiology Tags: Annals of Nuclear Medicine Source Type: journals

Contact dermatitis to captoprilEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Contact Dermatitis)
Source: Contact Dermatitis - September 22, 2009 Category: Dermatology Authors: Flora Balieva, Bjarte Steinkjer Tags: Contact Points Source Type: journals

Long-term stability of extemporaneously prepared captopril oral liquids in glass bottles.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Extemporaneously prepared oral liquid formulations of captopril 1 and 5 mg/mL were chemically stable when stored in glass bottles at room temperature for 12 months when stabilized with 0.1 mg/ mL disodium edetate at a low pH. PMID: 19767378 [PubMed - as supplied by publisher] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - September 22, 2009 Category: Drugs & Pharmacology Authors: Brustugun J, Lao YE, Fagernæs C, Brænden J, Kristensen S Tags: Am J Health Syst Pharm Source Type: journals

Capozide (hydrochlorothiazide/ captopril) LS Tablets - Product discontinuedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: eMC (electronic Medicines Compendium) Area: Other Library Updates > SPC Changes Capozide (hydrochlorothiazide/ captopril) LS tablets from ER Squibb have been discontinued. (Source: NeLM - Cardiovascular Medicine)
Source: NeLM - Cardiovascular Medicine - September 15, 2009 Category: Cardiology Source Type: organizations

Synthesis, Synchrotron X-ray Diffraction, and Kinetic Studies on the Formation of a Novel Thiolatocobalamin of Captopril: Evidence for cis-trans Isomerization in the β-Axial LigandEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Inorganic Chemistry, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Inorganic Chemistry)
Source: Inorganic Chemistry - September 11, 2009 Category: Chemistry Tags: article Source Type: journals

Non-NMDA receptors in the lateral parabrachial nucleus modulate sodium appetite.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Glutamatergic mechanisms have been implicated in the control of fluid ingestion. In the present study, we investigated whether non-N-methyl-D-aspartate (NMDA) glutamatergic receptors in the lateral parabrachial nucleus (LPBN) are involved in the control of water and sodium intake. Male Sprague-Dawley rats had cannulas implanted bilaterally into the LPBN. They were acutely depleted of water and sodium by injections of the diuretic furosemide (Furo; 10 mg/kg, bw) and a low dose of the angiotensin-converting enzyme inhibitor, captopril (Cap; 5 mg/kg, bw). Bilateral LPBN injections of the non-NMDA receptor antagonist DNQX ...
Source: Brain Research - September 7, 2009 Category: Neurology Authors: De Gobbi JI, Beltz TG, Johnson RF, Menani JV, Thunhorst RL, Johnson AK Tags: Brain Res Source Type: journals

Secondary prevention of ischaemic cardiac eventsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
New evidence; conclusions changed for: Anticoagulants in addition to antiplatelet treatments: Two systematic reviews added comparing intensive warfarin plus aspirin versus aspirin alone. Both reviews found that warfarin plus aspirin decreased the risk of non-fatal MI and stroke, but increased the risk of major bleeding compared with aspirin alone in people with acute coronary syndrome. The evidence supports the recategorisation from Likely to be ineffective or harmful to Trade-off between benefits and harms. Fish oil consumption (from oily fish or capsules): Two systema...
Source: Clinical Evidence - September 7, 2009 Category: Journals (General) Source Type: journals

Production and Secretion of Adiponectin from 3T3-L1 Adipocytes: Comparison of Antihypertensive Drugs.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ConclusionIn this comparative model, telmisartan, and to a lesser extent, losartan, increased production and secretion of adiponectin from 3T3-L1 adipocytes compared to the other antihypertensive drugs.American Journal of Hypertension 2009; doi:10.1038/ajh.2009.171. PMID: 19730415 [PubMed - as supplied by publisher] (Source: American Journal of Hypertension)
Source: American Journal of Hypertension - September 2, 2009 Category: Cardiology Authors: Brody R, Peleg E, Grossman E, Sharabi Y Tags: Am J Hypertens Source Type: journals

Catalytic properties of recombinant dipeptidyl carboxypeptidase from Escherichia coli: a comparative study with angiotensin I-converting enzymeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Biological Chemistry 390 (9): 931-940 Abstract Dipeptidyl carboxypeptidase from Escherichia coli (EcDcp) is a zinc metallopeptidase with catalytic properties closely resembling those of angiotensin I-converting enzyme (ACE). However, EcDcp and ACE are classified in different enzyme families (M3 and M2, respectively) due to differences in their primary sequences. We cloned and expressed EcDcp and studied in detail the enzyme's S3 to S1′ substrate specificity using positional-scanning synthetic combinatorial (PS-SC) libraries of fluorescence resonance energy transfer (FRET) peptides. These peptides contain ortho-aminobenzo...
Source: Biological Chemistry - September 1, 2009 Category: Chemistry Source Type: journals

Effects of microinjection of angiotensin II and captopril to VTA on morphine self-administration in rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study suggests the probable interaction between Ang II and opioid system in the VTA. PMID: 19700383 [PubMed - in process] (Source: Acta Biologica Hungarica)
Source: Acta Biologica Hungarica - August 27, 2009 Category: Biology Authors: Hosseini M, Alaei HA, Havakhah S, Neemati Karimooy HA, Gholamnezhad Z Tags: Acta Biol Hung Source Type: journals

Captopril: Exacerbation of Parkinson's disease in an elderly patient: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - August 24, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Captopril: Lichenoid eruption in an elderly patient: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - August 24, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Inhibition of intracellular Angiotensin II formation blocks high glucose effect on mesangial matrix.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
High glucose causes increased matrix synthesis by glomerular mesangial cells and angiotensin II (Ang II) has been shown to mediate this effect of glucose. These studies investigate whether inhibition of Ang II formation can block high glucose-induced increase in mesangial matrix. Human mesangial cells were incubated with 25mM glucose (HG) along with captopril, an ACE inhibitor to block Ang II formation. In other experiments, cells were nucleofected with siRNA to knockdown angiotensinogen (Agt), the precursor of Ang II, and then exposed to high glucose. Captopril blocked high glucose-induced increase in Ang II levels in...
Source: Regulatory Peptides - August 23, 2009 Category: Biochemistry Authors: Singh R, Choubey D, Chen J, Leehey DJ Tags: Regul Pept Source Type: journals

Evaluation of lipid profile in diabetic and hypertensive patients treated with captoprylEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
INTRODUÇÃO E JUSTIFICATIVA: Doença arterial coronariana (DAC) é a principal causa mundial de morte em indivíduos adultos, e como importantes fatores de risco tratáveis envolvidos estão o diabetes mellitus (DM), as dislipidemias e a hipertensão arterial sistêmica (HAS). O tratamento com anti-hipertensivos pode provocar alterações indesejáveis no perfil lipídico, atenuando seus efeitos benéficos antiaterogênicos na redução da pressão arterial (PA). OBJETIVO: Avaliar o perfil lipídico de indivíduos diabéticos tipo 2 com hipertensão essencial tratados somente com captopril ou em combinação com outros an...
Source: Jornal Brasileiro de Patologia e Medicina Laboratorial - August 22, 2009 Category: Pathology Source Type: journals

Combination of Captopril and Allopurinol Retards Fructose-Induced Metabolic Syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: A high fructose diet can induce metabolic syndrome even in the setting of caloric restriction. Captopril and allopurinol synergistically reduce features of the metabolic syndrome, especially hypertension, insulin resistance and dyslipidemia. Combination allopurinol and ACE inhibitor therapy might provide a superior means to prevent diabetes and cardiovascular disease. PMID: 19696478 [PubMed - as supplied by publisher] (Source: American Journal of Nephrology)
Source: American Journal of Nephrology - August 20, 2009 Category: Urology & Nephrology Authors: Roncal CA, Reungjui S, Sánchez-Lozada LG, Mu W, Sautin YY, Nakagawa T, Johnson RJ Tags: Am J Nephrol Source Type: journals

Effect of chronic pre-treatment with angiotensin converting enzyme inhibition on skeletal muscle mitochondrial recovery after ischemia/reperfusionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Impaired skeletal muscle energetic participates in peripheral arterial disease (PAD) patient's morbidity and mortality. Angiotensin converting enzyme inhibition (ACEi), cornerstone for pharmacologic risk factor management in PAD patients, might also be interesting by protecting skeletal muscle energetic. We therefore determined whether chronic ACEi might reduce ischemia-induced mitochondrial respiratory chain dysfunction in the frequent setting of hindlimb ischemia[ndash]reperfusion. Ischemic legs of rats submitted to 5 h ischemia induced by a rubber band tourniquet applied on the root of the hindlimb followed by reperfusi...
Source: Fundamental and Clinical Pharmacology - August 13, 2009 Category: Drugs & Pharmacology Authors: Fabien Thaveau, Joffrey Zoll, Jamal Bouitbir, Benoît N'Guessan, Philippe Plobner, Nabil Chakfe, Jean-Georges Kretz, Ruddy Richard, François Piquard, Bernard Geny Source Type: journals

Combinational chelation therapy abrogates lead induced neurodegeneration in rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lead, a ubiquitous and potent neurotoxicant causes oxidative stress which leads to numerous neurobehavioral and physiological alterations. The ability of lead to bind sulfhydryl groups or compete with calcium could be one of the reasons for its debilitating effects. In the present study, we addressed: i) if chelation therapy could circumvent the altered oxidative stress and prevent neuronal apoptosis in chronic lead-intoxicated rats, ii) whether chelation therapy could reverse biochemical and behavioral changes, iii) if mono or combinational therapy with captopril (an antioxidant) and thiol chelating agents (DMSA/MiADM...
Source: Toxicology and Applied Pharmacology - July 8, 2009 Category: Toxicology Authors: Pachauri V, Saxena G, Mehta A, Mishra D, Flora SJ Tags: Toxicol Appl Pharmacol Source Type: journals

Implantation of a three-dimensional fibroblast matrix improves left ventricular function and blood flow after acute myocardial infarction.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was designed to determine if a viable biodegradable three-dimensional fibroblast construct (3DFC) patch implanted on the left ventricle after myocardial infarction (MI) improves left ventricular (LV) function and blood flow. We ligated the left coronary artery of adult male Sprague-Dawley rats and implanted the 3DFC at the time of the infarct. Three weeks after MI, the 3DFC improved LV systolic function by increasing (p < 0.05) ejection fraction (37 +/- 3% to 62 +/- 5%), increasing regional systolic displacement of the infarcted wall (0.04 +/- 0.02 to 0.11 +/- 0.03 cm), and shifting the passive LV diastolic p...
Source: Cell Transplantation - July 1, 2009 Category: Cytology Authors: Thai HM, Juneman E, Lancaster J, Hagerty T, Do R, Castellano L, Kellar R, Williams S, Sethi G, Schmelz M, Gaballa M, Goldman S Tags: Cell Transplant Source Type: journals

Effect of different vasodilators on NTPDase activity in healthy and hypertensive patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: It is postulated that there was an interaction between vasodilators, NO donors and inhibition of NTPDase. (Source: Thrombosis Research)
Source: Thrombosis Research - June 30, 2009 Category: Hematology Authors: Daniéle Sausen Lunkes, Gilberto Inácio Lunkes, Mushtaq Ahmed, André L.B. Morsch, Rafael Fernandes Zanin, Paula Acosta Maldonado, Maísa Corrêa, Maria Rosa Chitolina Schetinger, Vera Maria Morsch Tags: Regular Articles Source Type: journals

Determination of free captopril in human plasma by liquid chromatography with mass spectrometry detection.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A new simple, sensitive and selective liquid chromatography coupled with mass spectrometry (LC/MS) method for quantification of captopril after precolumn derivatization with p-bromo-phenacyl-bromide in human plasma was validated. Plasma samples were analysed on a monolithic column (Cromolith Performance-RP 18e, 100 mm x 4.6 mm I.D., 3 microm) under isocratic conditions using a mobile phase of a 40:60 (v/v) mixture of acetonitrile and 0.1% (v/v) formic acid in water. The flow rate was 1 mL/min at the column temperature of 30 degrees C. In these chromatographic conditions, the retention time was 4.4 min for captopril der...
Source: Talanta - June 30, 2009 Category: Chemistry Authors: Vancea S, Imre S, Donáth-Nagy G, Béla T, Nyulas M, Muntean T, Borka-Balás R Tags: Talanta Source Type: journals

Rapid analysis of captopril in human plasma and pharmaceutical preparations by headspace solid phase microextraction based on polypyrrole film coupled to ion mobility spectrometry.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A rapid, simple, and sensitive headspace solid phase microextraction coupled to ion mobility spectrometry (HS-SPME-IMS) method is presented for analysis of the highly specific angiotensin-converting enzyme (ACE) inhibitor, captopril (CAP). Positive ion mobility spectra of CAP were acquired with an ion mobility spectrometer equipped with a corona discharge ionization source. Mass-to-mobility correlation equation was used to identify product ions. A dodecylsulfate-doped polypyrrole (PPy-DS) coating was used as a fiber for SPME. The results showed that PPy-DS based SPME fiber was suitable for successfully extracting CAP f...
Source: Talanta - June 30, 2009 Category: Chemistry Authors: Karimi A, Alizadeh N Tags: Talanta Source Type: journals

Captopril: Angioedema in an elderly patient: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - June 29, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Preservation and Modulation of Peritoneal Function. A Potential Role of Pyruvate and Betaine.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Efforts focused in improving the dialyzing capabilities of the peritoneal membrane by means of pharmacological manipulation, have not yet offered clinically relevant innovations. Conversely, interventions designed to preserve the peritoneum as a reusable dialyzing living membrane are more promising, especially those aimed at neutralizing oxidative and osmotic injury. PMID: 19494598 [PubMed - as supplied by publisher] (Source: Contributions to Nephrology)
Source: Contributions to Nephrology - June 27, 2009 Category: Urology & Nephrology Authors: Gotloib L Tags: Contrib Nephrol Source Type: journals

Captopril: Angioedema in an elderly patient: case report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 9 (Source: Reactions Weekly)
Source: Reactions Weekly - June 27, 2009 Category: Drugs & Pharmacology Tags: HTML Source Type: journals

Captopril/imipenem: Linear IgA bullous dermatosis in an elderly patient: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - June 17, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Captopril/imipenem: Linear IgA bullous dermatosis in an elderly patient: case report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 11 (Source: Reactions Weekly)
Source: Reactions Weekly - June 15, 2009 Category: Drugs & Pharmacology Tags: HTML Source Type: journals

Inhibition of renin-angiotensin system in experimental acute pancreatitis in rats: A new therapeutic target?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: This study not only demonstrated the differential effects of captopril, losartan and L-158809 in acute pancreatitis but also showed that there is still much to investigate about pancreatic renin-angiotensin system. Inhibition of angiotensin-converting enzyme should be evaluated carefully as a potential new therapeutic target in acute pancreatitis. PMID: 19525099 [PubMed - as supplied by publisher] (Source: Experimental and Toxicologic Pathology)
Source: Experimental and Toxicologic Pathology - June 11, 2009 Category: Pathology Authors: Oruc N, Ozutemiz O, Nart D, Yuce G, Celik HA, Ilter T Tags: Exp Toxicol Pathol Source Type: journals

Usefulness of Beta Blockers in High-Risk Patients After Myocardial Infarction in Conjunction With Captopril and/or Valsartan (from the VALsartan In Acute Myocardial Infarction [VALIANT] Trial)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, no evidence was found of adverse interactions between the angiotensin-receptor blocker valsartan and β blockers or of a negative effect of the combination of valsartan, captopril, and β blockers. (Source: The American Journal of Cardiology)
Source: The American Journal of Cardiology - June 3, 2009 Category: Cardiology Authors: Robert M. Califf, Yuliya Lokhnygina, Eric J. Velazquez, John J.V. McMurray, Jeffrey D. Leimberger, Eldrin F. Lewis, Rafael Diaz, Jan Murin, Marc A. Pfeffer Tags: Coronary Artery Disease Source Type: journals

Synergistic decrease in blood pressure by captopril combined with losartan in spontaneous hypertensive rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was designed to examine the anti-hypertensive effect of the combination therapy of captopril with losartan by oral administration using both independent and cross-over experimental protocols. In independent experimental protocols, four different groups of spontaneous hypertensive rats (SHR) were treated for 1 or 2 weeks: control, captopril (20 mg/kg/day), losartan (20 mg/kg/day), and combination captopril (10 mg/kg/day) with losartan (10 mg/kg/day). In cross-over protocols, each SHR received all four treatments for 1 or 3 days with an interval of several days between each injection for washing-out and return to ...
Source: Archives of Pharmacal Research - May 31, 2009 Category: Drugs & Pharmacology Authors: Shin CY, Choi WS, Yi I, Nan MH, Myung CS Tags: Arch Pharm Res Source Type: journals

Involvement of central angiotensin II type 1 receptors in LPS-induced systemic vasopressin release and blood pressure regulation in ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The purpose of this study was to evaluate the involvement of central angiotensin II (ANG II) and ANG II type 1 (AT1) receptors in systemic release of arginine vasopressin (AVP) and blood pressure regulation during endotoxemia. LPS (150 µg/kg) was injected intravenously 30 min after intracerebroventricular (icv) losartan (50 µg), an AT1 receptor antagonist, or subcutaneous (sc) captopril (50 mg/kg), an angiotensin-converting enzyme inhibitor. Rats with icv and sc saline injections served as control. LPS administration increased plasma AVP concentration from 2.1 ± 0.2 to 15.2 ± 2.5 pg/ml (60 min aft...
Source: Journal of Applied Physiology - May 26, 2009 Category: Physiology Authors: Shimizu, F., Kasai, T., Takamata, A. Tags: ARTICLES Source Type: journals

Assay of free captopril in human plasma as monobromobimane derivative, using RPLC/(+)ESI/MS/MS: validation aspects and bioequivalence evaluation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A sensitive method for determination of free captopril as monobromobimane derivative in plasma samples is discussed. The internal standard (IS) was 5-methoxy-1H-benzimidazole-2-thiol. Derivatization with monobromobimane immediately after blood collection and plasma preparation prevents oxidation of captopril to the corresponding disulfide compound and enhances the ionization yield. Consequently, derivatization enhances sample stability and detection sensitivity. Addition of the internal standard was made immediately after plasma preparation. The internal standard was also derivatized by monobromobimane, as it contains ...
Source: Biomedical Chromatography : BMC - April 28, 2009 Category: Biomedical Science Authors: Medvedovici A, Albu F, Sora ID, Udrescu S, Galaon T, David V Tags: Biomed Chromatogr Source Type: journals

Induction of apoptosis in leukemic cell lines treated with captopril, trandolapril and losartan: A new role in the treatment of leukaemia for these agentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Renin–angiotensin system (RAS) in the bone marrow is related to proliferation and cellular differentiation. We investigated the effect of ACE inhibitors (ACEI) captopril (>1mM) and trandolapril (>0.05mM) and losartan (0.2mM) on K562 cell line and K562 transfected with c-myc, bcl-x and bcl-2 (KmycB, Kbclx and Kbcl2 respectively). RAS components, proliferation, apoptosis and c-myc expression were analyzed. ACEI and losartan inhibited cell growth, decreased c-myc expression and increased apoptosis. These effects seem to be associated to angiotensin II-induced Smad activation. This work offers a new possible line o...
Source: Leukemia Research - April 24, 2009 Category: Hematology Authors: Silvia De la Iglesia Iñigo, Carmen Elsa López-Jorge, Maria Teresa Gómez-Casares, Angelina Lemes Castellano, Pedro Martín Cabrera, Jezabel López Brito, Alexia Suárez Cabrera, Teresa Molero Labarta Tags: Laboratory Studies Source Type: journals

Regulation of Oxygen Utilization by Angiotensin II in Chronic Kidney DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Angiotensin II blockade effects on renal oxygen consumption are measured with captopril and losartan on board to determine what underlies the angiotensin II blockade benefit - besides hemodynamics? Kidney International (Source: Medscape Urology Headlines)
Source: Medscape Urology Headlines - April 23, 2009 Category: Urology & Nephrology Tags: Nephrology Source Type: info

Contrasting effects of steroids and angiotensin-converting-enzyme inhibitors in a mouse model of dystrophin-deficient cardiomyopathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion In a mouse model of dystrophin-deficient cardiomyopathy, ACE-I produced haemodynamic benefit, whereas steroids accelerated progression of cardiomyopathy. Although mouse models may not entirely replicate the human condition, comprehensive monitoring of cardiac function with these therapies is essential. (Source: European Journal of Heart Failure)
Source: European Journal of Heart Failure - April 22, 2009 Category: Cardiology Authors: Bauer, R., Straub, V., Blain, A., Bushby, K., MacGowan, G. A. Tags: EXPERIMENTAL Source Type: journals

Role of symmetric dimethylarginine in vascular damage by increasing ROS via store-operated calcium influx in monocytesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. SDMA, a uraemic retention solute considered inert, stimulates ROS production of monocytes by acting on Ca2+ entry via SOCs. This pro-inflammatory effect may trigger vascular pathology and may be involved in altering the prevalence of cardiovascular disease in CKD. (Source: Nephrology Dialysis Transplantation)
Source: Nephrology Dialysis Transplantation - April 14, 2009 Category: Urology & Nephrology Authors: Schepers, E., Glorieux, G., Dhondt, A., Leybaert, L., Vanholder, R. Tags: Experimental Nephrology Source Type: journals

Effects of three vasoactive peptides isolated from the plasma of the snake Bothrops jararaca.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Effects of three vasoactive peptides isolated from the plasma of the snake Bothrops jararaca. Comp Biochem Physiol C Toxicol Pharmacol. 2009 May;149(4):552-8 Authors: Barreto SA, Chaguri LC, Prezoto BC, Lebrun I Incubation of plasma from the snake Bothrops jararaca (BJP) with trypsin generated two hypotensive peptides. The primary structure of the peptides was established for three sequences as: Asn-Pro-Phe-Val-Asp-Ala (fraction 13), Ser-Lys-Pro-Asn-Met-Ser-Asp-Glu-Ser-Leu-Ala-Val-Ala-Ile (fraction 14), Asn-Pro-Phe- Val-Asp-Ala (fraction 15). These peptides display homology with fragments of albumin from Trimer...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - April 11, 2009 Category: Biochemistry Authors: Barreto SA, Chaguri LC, Prezoto BC, Lebrun I Tags: Comp Biochem Physiol C Toxicol Pharmacol Source Type: journals

Implantation of a 3-dimensional fibroblast matrix improves left ventricular function and blood flow after acute myocardial infarction.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: This biodegradable 3DFC patch improves LV function and myocardial blood flow 3 weeks after MI. This is a potentially new approach to cell-based therapy for heart failure after MI. PMID: 19500469 [PubMed - as supplied by publisher] (Source: Cell Transplantation)
Source: Cell Transplantation - April 9, 2009 Category: Cytology Authors: Thai HM, Juneman E, Lancaster J, Hagerty T, Do R, Castellano L, Kellar R, Williams S, Sethi G, Schmelz M, Gaballa M, Goldman S Tags: Cell Transplant Source Type: journals