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Transient lower limb pain following accidental thoracic subarachnoid insertion of an epidural catheterEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of transient lower limb pain following the accidental placement of an epidural catheter into the thoracic subarachnoid space. A 31-year-old woman was scheduled to undergo laparoscopic myomectomy. An epidural catheter was accidentally inserted subarachnoid at the T12–L1 intervertebral space with a 2-ml test dose of 2% lidocaine, and was promptly removed. Fulgurant pain and allodynia extending over the L2–5 areas of the left lower limb and buttock started immediately postoperatively. We treated the persistent pain in our patient with epidural infusion of local anesthetics and steroids during her hos...
Source: Journal of Anesthesia - November 17, 2009 Category: Anesthesiology Tags: Journal of Anesthesia Source Type: journals

Carbamazepine: Exacerbation of idiopathic generalised epilepsy: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - November 16, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Carbamazepine: Hyperammonaemia: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - November 16, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Inhibition of specific adenylyl cyclase isoforms by lithium and carbamazepine, but not valproate, may be related to their antidepressant effectEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Lithium and carbamazepine preferentially inhibit AC5, albeit via different mechanisms. Lithium competes with Mg2+, which is essential for AC activity; carbamazepine competes for AC's catechol-estrogen site. Antidepressant-like behavior of AC5 knockout mice in the forced-swim test supports the notion that AC5 inhibition is involved in the antidepressant effect of lithium and carbamazepine. The effect of lithium and carbamazepine to lower cAMP formation in AC5-rich dopaminergic brain regions suggests that D1-dopamine receptors in these regions are involved in the antidepressant effect of mood stabilizers. (Sourc...
Source: Bipolar Disorders - November 16, 2009 Category: Psychiatry Authors: Liad Mann, Eliahu Heldman, Yuly Bersudsky, Stephen F Vatner, Yoshihiro Ishikawa, Orna Almog, Robert H Belmaker, Galila Agam Tags: Original Articles Source Type: journals

[Music as an uninvited guest: the auditive variant of the Charles Bonnet syndrome.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Visually handicapped patients can be tormented by complex visual hallucinations (Charles Bonnet syndrome). Likewise, deaf patients and patients with impaired hearing can be plagued by auditory hallucinations, mostly involving music. Our article focuses on three female patients who suffered from musical hallucinations. In one of these patients the hallucinations ceased when her hearing was restored. In the second patient the hallucinations ceased when carbamazepine was prescribed. Quetiapine reduced the musical hallucinations in the third patient. The differential diagnoses and therapeutic options are discussed. PMI...
Source: Tijdschrift voor Psychiatrie - November 13, 2009 Category: Psychiatry Authors: Tuerlings JH, Wijnen H, Boerman R, Verwey B Tags: Tijdschr Psychiatr Source Type: journals

Association of HLA-B*1502 allele and carbamazepine-induced <i>Stevens-Johnson syndrome</i> among IndiansEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion:</b> This study suggests an association between HLA-B*1502 and carbamazepine-induced SJS in Indian patients. (Source: Indian Journal of Dermatology, Venereology and Leprology)
Source: Indian Journal of Dermatology, Venereology and Leprology - November 12, 2009 Category: Dermatology Authors: Mehta Timir Y, Prajapati Laxman M, Mittal Bharti, Joshi Chaitanya G, Sheth Jayesh J, Patel Dinesh B, Dave Dinkar M, Goyal Ramesh K Source Type: journals

Occurrence and fate of pharmaceuticals in wastewater treatment plants and rivers in Korea.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We measured 25 pharmaceuticals in ten municipal wastewater treatment plants (WWTPs), one hospital WWTP and five rivers in Korea. In the municipal WWTP influents, acetaminophen, acetylsalicylic acid and caffeine showed relatively high concentrations. The occurrence of pharmaceuticals in the wastewater seems to be influenced by production and consumption of pharmaceuticals. The hospital WWTP influent showed higher total concentrations of pharmaceuticals than the municipal WWTPs, and caffeine, ciprofloxacin and acetaminophen were dominant. In the rivers, caffeine was dominant, and the distribution of pharmaceuticals was r...
Source: Environmental Pollution - November 12, 2009 Category: Environmental Health Authors: Sim WJ, Lee JW, Oh JE Tags: Environ Pollut Source Type: journals

Carbamazepine: Drug-induced hypersensitivity syndrome and granulomatous dermatitis: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - November 11, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Role of Ventral Hippocampal GABA A and NMDA Receptors in the Anxiolytic Effect of Carbamazepine in Rats Using the Elevated Plus Maze TestEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pharmacology 2009;84:356-366 (DOI:10.1159/000256666) (Source: Pharmacology)
Source: Pharmacology - November 10, 2009 Category: Drugs & Pharmacology Source Type: journals

Antieplipetic treatment eslicarbazepine acetate (Zebinix®) launched in UKEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: PharmaTimes Area: News Eisai has launched eslicarbazepine acetate (Zebinix®) in the UK as adjunctive therapy in adults with partial-onset seizures, with or without secondary generalisation. The drug, which is chemically related to carbamazepine and oxcarbazepine, is administered as a once daily regimen. The recommended starting dose is 400mg/d, increased to 800mg/d once daily after one or two weeks, and based on individual response, it may be increased to 1200mg/d. The cost of 30 x 800mg tablets is £154.20. (Source: NeLM - News)
Source: NeLM - News - November 10, 2009 Category: Drugs & Pharmacology Source Type: organizations

Carbamazepine for serotonin reuptake inhibitor nonresponder case of obsessive compulsive disorderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aggarwal Ashish, Jain Manish, Garg Amit, Jiloha R CIndian Journal of Medical Sciences 2009 63(10):468-469 (Source: Indian Journal of Medical Sciences)
Source: Indian Journal of Medical Sciences - November 7, 2009 Category: Journals (General) Authors: Aggarwal Ashish, Jain Manish, Garg Amit, Jiloha R C Source Type: journals

Positive interference of the analgesic nefopam in the urine immunoassay for benzodiazepines in a secure settingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An inpatient on a secure unit with a history of bipolar affective disorder and physical complaints including pain was prescribed carbamazepine, quetiapine, dihydrocodeine, nefopam, paracetamol and various aperients. A benzodiazepine urine test by immunoassay was positive. Initial literature searches did not suggest a candidate drug for positive interference. Other explanations were excluded. Positive results continued, despite room searches and other disruptive security measures. Further literature searches revealed one experimental series demonstrating positive interference of nefopam in the relevant assay. Benzodiazepine...
Source: Journal of Psychopharmacology - November 5, 2009 Category: Psychiatry Authors: Reid, K. Tags: Articles Source Type: journals

A prospective study of cognitive fluency and originality in children exposed in utero to carbamazepine, lamotrigine, or valproate monotherapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Children prenatally exposed to valproate demonstrate impaired fluency and originality compared with children exposed to lamotrigine and carbamazepine. PMID: 19892603 [PubMed - as supplied by publisher] (Source: Epilepsy and Behaviour)
Source: Epilepsy and Behaviour - November 3, 2009 Category: Neurology Authors: McVearry KM, Gaillard WD, Vanmeter J, Meador KJ Tags: Epilepsy Behav Source Type: journals

Responses of antioxidant status and Na(+)-K(+)-ATPase activity in gill of rainbow trout, Oncorhynchus mykiss, chronically treated with carbamazepine.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In recent years, chemical pollution by the residual pharmaceuticals has been increasingly important issue due to its widely present in the aquatic environment. However, the toxicological effects of residual pharmaceuticals on fish have not been adequately researched. The aim of this work is to investigate the toxic effect of CBZ, an anticonvulsant drug commonly present in aquatic environment, on antioxidant status and Na(+)-K(+)-ATPase in gill of rainbow trout exposed to sublethal CBZ (1.0mugL(-1), 0.2mgL(-1) and 2.0mgL(-1)) for 7, 21 and 42d. After prolonged exposure of CBZ at higher test concentration (0.2 or 2.0mgL(...
Source: Chemosphere - November 2, 2009 Category: Chemistry Authors: Li ZH, Zlabek V, Velisek J, Grabic R, Machova J, Randak T Tags: Chemosphere Source Type: journals

Modeling the influence of cyclodextrins on oral absorption of low solubility drugs: II. Experimental validationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A model was developed for predicting the influence of cyclodextrins (CDs) delivered as a physical mixture with drug on oral absorption. CDs are cyclic oligosaccharides which form inclusion complexes with many drugs and are often used as solubilizing agents. The purpose of this work is to compare the simulation predictions with in vitro as well as in vivo experimental results to test the model's ability to capture the influence of CD on key processes in the gastrointestinal (GI) tract environment. Dissolution and absorption kinetics of low solubility drugs (Naproxen and Nifedipine) were tested in the presence and absence of...
Source: Biotechnology and Bioengineering - November 1, 2009 Category: Biomedical Science Authors: Ece Dilber Gamsiz, Lee Miller, Avinash G. Thombre, Imran Ahmed, Rebecca Lyn Carrier Source Type: journals

Is asymmetric dimethylarginine responsible for the vascular events in patients under antiepileptic drug treatment?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion our data suggest that elevated ADMA levels may be responsible for the increased cardiovascular risk in patients with epilepsy under AED therapy. (Source: Epilepsy Research)
Source: Epilepsy Research - November 1, 2009 Category: Neurology Authors: Oğuzhan Öz, Zeki Gökçil, Semai Bek, Erdinç Çakır, Zeki Odabaşı Tags: Research Papers Source Type: journals

The clinical challenge of SIADH-three cases.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The syndrome of inappropriate antidiuretic hormone secretion (SIADH) remains a challenging disorder to diagnose and treat. Three cases are presented to illustrate these challenges. The first two cases had drug-induced SIADH secondary to a selective serotonin reuptake inhibitor (for depression) or carbamazepine (for trigeminal neuralgia). The third case had SIADH possibly secondary to bronchiectasis. The lowest serum sodium concentrations ranged between 118 and 124 mmol/L in the three cases. Hyponatraemia was not acute and severe symptoms were absent. However, several mild neurological symptoms were present. In the firs...
Source: NDT Plus - November 1, 2009 Category: Urology & Nephrology Authors: van der Lubbe N, Thompson CJ, Zietse R, Hoorn EJ Tags: NDT Plus Source Type: journals

Prescriber compliance with black box warnings in older adult patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Administrative claims analysis identified low rates of prescriber compliance with BBWs in managing patients age >or=65 years. Claims analysis may be a cost-effective strategy to monitor prescriber compliance with BBWs in older patients at higher risk. PMID: 19895180 [PubMed - in process] (Source: The American Journal of Managed Care)
Source: The American Journal of Managed Care - November 1, 2009 Category: Health Management Authors: Ricci JR, Coulen C, Berger JE, Moore MC, McQueen A, Jan SA Tags: Am J Manag Care Source Type: journals

[Co-analgesics--today and tomorrow--a receptor-based overview of therapeutical options]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe the peripheral action sites of co-analgesics, such as cannabinoids, capsaicin, bisphosphonates, steroids and somatostatin. We also summarise the effect of peripherally and centrally acting ion-channel blockers, e.g. local anaesthetics, carbamazepine and tolperisone working on sodium channels and gabapentin and pregabalin working on calcium channels. Finally, central analgesic mechanisms are discussed, for instance the inhibition of NMDA-receptors by ketamine or magnesium, the stimulation of alpha2-receptors by clonidine, tizanidine or antidepressants, the activation of GABA-receptors through baclofen and other ...
Source: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS - November 1, 2009 Category: Intensive Care Authors: Wörner J, Rukwied R, Konrad C Tags: Anasthesiol Intensivmed Notfallmed Schmerzther Source Type: journals

Carbamazepine/risperidone: Lichenoid drug eruptions: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - October 31, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

CARBATROL (Carbamazepine) Capsule [Physicians Total Care, Inc.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Oct 30, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - October 30, 2009 Category: Drugs & Pharmacology Source Type: organizations

Human health risk assessment of carbamazepine in surface waters of North America and Europe.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A human health risk assessment was carried out for environmental exposures to carbamazepine (CBZ) and its major human metabolites, carbamazepine diol (CBZ-DiOH) and carbamazepine N-glucuronide (CBZ-N-Glu). Carbamazepine is an active pharmaceutical ingredient (API) used worldwide as a medicine for treating epileptic seizures and trigeminal neuralgia. Carbamazepine tends to be detected in surface water more frequently and at relatively higher concentrations, than most other APIs. Predicted no effect levels (PNECs) for CBZ and its major human metabolites were developed for surface waters to be protective of human health f...
Source: Regulatory Toxicology and Pharmacology : RTP - October 30, 2009 Category: Toxicology Authors: Cunningham VL, Perino C, D'Aco VJ, Hartmann A, Bechter R Tags: Regul Toxicol Pharmacol Source Type: journals

Teratogenic Effects of Antiepileptic MedicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
During the last few years epilepsy and pregnancy registries and other large scale observational studies have provided new information on the teratogenic effects of the most frequently used antiepileptic drugs (AEDs). The prevalence of major congenital malformations associated with exposure to carbamazepine or lamotrigine appears to be only marginally increased from the expected, while malformation rates with valproate have been reported to be 2 to 4 times higher. Recent studies also suggest that compared with carbamazepine, lamotrigine and phenytoin, exposure to valproate in utero may be associated with poorer postnatal co...
Source: Neurologic Clinics - October 24, 2009 Category: Neurology Authors: Torbjörn Tomson, Dina Battino Source Type: journals

Eslicarbazepine Acetate Evaluated for Partial-Onset SeizuresEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The experimental drug, similar to carbamazepine, may reduce seizure frequency in refractory patients. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 23, 2009 Category: Consumer Health News Tags: Neurology & Neurosurgery Source Type: news

Effect of acute and chronic treatment with milnacipran potentiates the anticonvulsant activity of conventional antiepileptic drugs in the maximal electroshock-induced seizures in miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Acute, but not chronic, treatment with MLN can increase the effectiveness of some AEDs against MES-induced seizures in mice. It seems that MLN may also be considered as a candidate drug for clinical trials in patients with epilepsy and depressive disorders. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1698-xAuthors Kinga K. Borowicz, Lublin Medical University Experimental Neuropathophysiology Unit, Department of Pathophysiology Jaczewskiego 8 Lublin PolandKamila Furmanek-Karwowska, Lublin Medical University Experimental Neuropathophysiology Unit, Depart...
Source: Psychopharmacology - October 20, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

The usefulness of olfactory bulb kindling as a model for evaluation of antiepilepticsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion: OB kindling can be used as a new valuable model to evaluate antiepileptic drugs, with the advantage of its rapid development and the efficacy of antiepileptics. (Source: Epilepsia)
Source: Epilepsia - October 19, 2009 Category: Neurology Authors: Akinori Fujiwara, Yusuke Watanabe, Kenshi Takechi, Takashi Ishikawa, Yuko Kaida, Masaaki Akagi, Chiaki Kamei Source Type: journals

Levodopa/tolcapone: Hypersexuality treated with carbamazepine in an elderly patient: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - October 19, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

No Pharmacokinetic Interaction Between Lacosamide and Carbamazepine in Healthy Volunteers.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lacosamide is a new antiepileptic drug for adjunctive treatment of adult partial-onset seizures. Two open-label, multiple-dose clinical trials were conducted to evaluate the potential for pharmacokinetic interaction between lacos amide and carbamazepine. The influence of carbamazepine on lacosamide pharmacokinetics (trial A) and lacosamide on carbamazepine pharmacokinetics (trial B) was investi gated in 19 (trial A) and 18 (trial B) healthy male partici pants. Trial A participants received lacosamide 200 mg bid alone and with carbamazepine 200 mg bid. Trial B partici pants received carbamazepine 200 mg bid alone and wi...
Source: The Journal of Clinical Pharmacology - October 18, 2009 Category: Drugs & Pharmacology Authors: Cawello W, Nickel B, Eggert-Formella A Tags: J Clin Pharmacol Source Type: journals

The Far-Reaching Influence of Hepatic Enzyme-Inducing Antiepileptic DrugsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Effects of Antiepileptic Drugs on Lipids, Homocysteine, and C-Reactive Protein. Mintzer S, Skidmore CT, Abidin CJ, Morales MC, Chervoneva I, Capuzzi DM, Sperling MR. Ann Neurol 2009;65:448[ndash]456. OBJECTIVE: The widely prescribed anticonvulsants phenytoin and carbamazepine are potent inducers of cytochrome P450 enzymes, which are involved in cholesterol synthesis. We sought to determine whether these drugs have an effect on cholesterol and other serological markers of vascular risk. METHODS: We recruited 34 epilepsy patients taking carbamazepine or phenytoin in monotherapy whose physicians had elected to change treatmen...
Source: Epilepsy Currents - October 15, 2009 Category: Neurology Authors: Bassel W. Abou-Khalil Tags: Current Literature in CLINICAL SCIENCE Source Type: journals

Oxcarbazepine for refractory epilepsy: systematic review of the literature.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: There is moderate evidence indicating that oxcarbazepine is effective as an alternative treatment for partial or generalized epilepsy in children and adults who were refractory to previous treatment. PMID: 19820875 [PubMed - in process] (Source: Sao Paulo Medical Journal)
Source: Sao Paulo Medical Journal - October 15, 2009 Category: Journals (General) Authors: Saconato H, Prado GF, Puga ME, Atallah AN Tags: Sao Paulo Med J Source Type: journals

[Teratogenic effects of lamotrigine in women with bipolar disorder.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: There are no strong indications that the use of lmt during pregnancy results in an increased number of major congenital malformations. PMID: 19821242 [PubMed - in process] (Source: Tijdschrift voor Psychiatrie)
Source: Tijdschrift voor Psychiatrie - October 14, 2009 Category: Psychiatry Authors: Berwaerts K, Sienaert P, De Fruyt J Tags: Tijdschr Psychiatr Source Type: journals

Synthesis of 6-(3-substituted-4H-1,2,4-triazol-4-yl)-2-phenylbenzo[d]oxazoles as potential anticonvulsant agentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract A series of 6-(3-substituted-4H-1,2,4-triazol-4-yl)-2-phenylbenzo[d]oxazoles was synthesized. The anticonvulsant effect and neurotoxicity of the compounds were calculated with maximal electroshock (MES) test, subcutaneous pentylenetetrazole (Sc-PTZ), and rotarod tests in intraperitoneally injected mice. Among the synthesized compounds, compound 2-phenyl-6-(4H-1,2,4-triazol-4-yl)benzo[d]oxazole (3a) could be considered the potentially most useful and safe therapeutic compound, with ED50 = 29.6 mg/kg, TD50 = 285 mg/kg, and PI = 9.7. Its neurotoxicity was the lowes...
Source: Medicinal Chemistry Research - October 14, 2009 Category: Chemistry Tags: Medicinal Chemistry Research Source Type: journals

Oxcarbazepine versus carbamazepine monotherapy for partial onset seizuresEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cochrane systematic review. Summary: Carbamazepine is the most commonly used drug to treat partial epileptic seizures. Oxcarbazepine is a newer drug that was developed with the intention to be as effective as carbamazepine but to cause fewer side effects. In this systematic review, we summarise three studies in which oxcarbazepine and carbamazepine treatment were compared directly. We found that both drugs appear to be equally effective and to cause side effects equally often. Significantly fewer patients on carbamazepine developed nausea or vomiting during treatment. (Source: Neurological Conditions Specialist Library)
Source: Neurological Conditions Specialist Library - October 13, 2009 Category: Neurology Source Type: organizations

Outpatient utilization of drugs acting on nervous system: a study from the Republic of Srpska, Bosnia & HerzegovinaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The observed tendency toward increased total drug utilization observed in our study is comparable to worldwide trends. Implementation of new clinical guidelines for nervous diseases and updating of the list of reimbursable drugs with the addition of new ones contributed to the observed improvement in prescribing patterns in primary healthcare during the study period. The DU90% is shown to be a simple rough method for assessing prescribing quality. More stratified analyses should be performed on a routine basis to ensure a rational use of medicines and a cost-efficient use of limited healthcare re...
Source: European Journal of Clinical Pharmacology - October 9, 2009 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

Updated MTRAC Verdict/Summary on levetiracetam (Keppra®)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: MTRAC Area: Evidence > Drug Specific Reviews The updated verdict on levetiracetam (Keppra®) for the treatment of partial onset seizures from the Midlands Therapeutics Review and Advisory Committee (MTRAC) is that it should be initiated and stabilised within secondary care, after which it is then appropriate for GPs to prescribe this treatment over the longer term, but patients are expected to receive continuing follow-up in secondary care. As a well established second line therapy, it is considered to have a relatively high place in therapy. The evidence was considered relatively strong for adults and children ov...
Source: NeLM - Drug Specific Reviews - October 8, 2009 Category: Drugs & Pharmacology Source Type: organizations

Solvent Effects on the Crystallization and Preferential Nucleation of Carbamazepine Anhydrous Polymorphs: A Molecular Recognition PerspectiveEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Organic Process Research & Development, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Organic Process Research)
Source: Organic Process Research - October 7, 2009 Category: Chemistry Tags: article Source Type: journals

Opinion of Belgian neurologists on antiepileptic drug treatment in 2006: Belgian study on epilepsy treatment (BESET-2)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions [ndash] In end 2006, carbamazepine, valproate and oxcarbazepine were considered to be first choice drugs, whereas other newer drugs, like lamotrigine, levetiracetam and topiramate were predominantly prescribed in second line. (Source: Acta Neurologica Scandinavica)
Source: Acta Neurologica Scandinavica - October 4, 2009 Category: Neurology Authors: B. Legros, P. Boon, P. De Jonghe, B. Sadzot, K. Van Rijckevorsel, E. Schmedding Source Type: journals

Antiepileptic drugs in Australia: 2002-2007Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined the trends in the prescribing of subsidised AEDs in the Australian population from 2002 to 2007.We analysed the Medicare Australia and Drug Utilisation Sub-Committee databases for script data for AEDs from 2002 to 2007 in 5-year age groups by gender and by class of prescriber. Scripts were converted to defined daily doses (DDDs)/1000/day using Australian Bureau of Statistics population data.Overall AED use (mainly valproate, lamotrigine and levetiracetam) increased progressively in 2002-2007 from 9.33 to 10.12 DDD/1000 population/day. Sodium valproate was the most widely used agent followed by carbamazepine the...
Source: Pharmacoepidemiology and Drug Safety - October 1, 2009 Category: Drugs & Pharmacology Authors: Samantha A Hollingworth, Mervyn J Eadie Source Type: journals

The Influence of Drug-Drug Interaction and Patients' Characteristics on Valproic Acid's Clearance in Adults with Epilepsy using Nonlinear Mixed Effects Modeling.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study confirms the interaction of VPA with TPR, which is presumably dependent on VPA dose. PMID: 19804822 [PubMed - as supplied by publisher] (Source: European Journal of Pharmaceutical Sciences)
Source: European Journal of Pharmaceutical Sciences - October 1, 2009 Category: Drugs & Pharmacology Authors: Vučićević K, Miljković B, Pokrajac M, Prostran M, Martinović Z, Grabnar I Tags: Eur J Pharm Sci Source Type: journals

Simultaneous determination of venlafaxine and its main active metabolite O-desmethyl venlafaxine in rat plasma by LC-MS/MS.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A simple, sensitive and selective liquid chromatography tandem mass spectrometry (LC-MS/MS) method was developed and validated for the analysis of venlafaxine (VX) and its major active metabolite O-desmethyl venlafaxine (ODV) in rat plasma using carbamazepine as an internal standard (IS). The analytes from the biological matrix were extracted by liquid-liquid extraction using tert-butyl methyl ether (TBME). The HPLC separation of the analytes was performed on a water symmetry C18 (150 x 4.6 mm i.d., 5 microm) column, using a 10 mM ammonium formate:methanol (20:80 v/v) as mobile phase. The calibration curve concentratio...
Source: Analytical Sciences : the international journal of the Japan Society for Analytical Chemistry - September 30, 2009 Category: Chemistry Authors: Shah GR, Thaker BT, Surati KR, Parabia MH Tags: Anal Sci Source Type: journals

Argatroban/carbamazepine/heparin: TEN, coagulation failure and fatal HIT: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - September 30, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Predicting physical properties of emerging compounds with limited physical and chemical data: QSAR model uncertainty and applicability to military munitions.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Reliable, up-front information on physical and biological properties of emerging materials is essential before making a decision and investment to formulate, synthesize, scale-up, test, and manufacture a new material for use in both military and civilian applications. Multiple quantitative structure-activity relationships (QSARs) software tools are available for predicting a material's physical/chemical properties and environmental effects. Even though information on emerging materials is often limited, QSAR software output is treated without sufficient uncertainty analysis. We hypothesize that uncertainty and variabil...
Source: Chemosphere - September 27, 2009 Category: Chemistry Authors: Bennett ER, Clausen J, Linkov E, Linkov I Tags: Chemosphere Source Type: journals

[Aetiology of epileptic seizures in a rehabilitation centre.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS. Epilepsy can limit rehabilitation therapy in patients with stroke or traumatic injury, due to the risk of developing difficult-to-treat epilepsy. Caregivers often have to take responsibility for the pharmacological treatment in disabled patients with brain damage. PMID: 19774528 [PubMed - in process] (Source: Revista de Neurologia)
Source: Revista de Neurologia - September 24, 2009 Category: Neurology Authors: Carod-Artal FJ, Vargas AP, Mesquita HM Tags: Rev Neurol Source Type: journals

Disinhibition Due to Disruption of the Orbitofrontal Circuit Treated Successfully With Carbamazepine: A Case Series [CLINICAL AND RESEARCH REPORTS]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The frontal-subcortical pathways play a role in governing behavior. Injury may disrupt their functioning and produce neuropsychiatric symptoms. The authors discuss the kindling theory in the possible production of these symptoms, which significantly improved with the potent antikindling agent, carbamazepine. (Source: J Neuropsychiatry Clin Neurosci)
Source: J Neuropsychiatry Clin Neurosci - September 22, 2009 Category: Neurology Authors: Spiegel, D. R., Burgess, J., Samuels, D., Laroia, R., Kirshenbaum, S. Tags: CLINICAL AND RESEARCH REPORTS Source Type: journals

Ghrelin levels are reduced in prepubertal epileptic children under treatment with carbamazepine or valproic acidEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A relationship between ghrelin and epilepsy has been already shown in humans, although the results are controversial. Ghrelin levels are reduced in obesity. Epileptic patients progressively develop a therapy-linked weight gain; however, the mechanisms for this have not been fully explained. The aim of our study is to evaluate if ghrelin secretion is modulated by treatment with carbamazepine or valproic acid in young prepubertal epileptic children. Ghrelin levels were reduced in normal-weight young epileptic prepubertal children under treatment with carbamazepine (p < 0.0001) or valproic acid (p < 0.006) compared to healthy...
Source: Epilepsia - September 21, 2009 Category: Neurology Authors: Flavia Prodam, Simonetta Bellone, Gianluca Casara, Francesca De Rienzo, Erica C. Grassino, Ilaria Bonsignori, Irene Demarchi, Anna Rapa, Giorgio Radetti, Gianni Bona Source Type: journals

Hyperhomocysteinemia in epileptic patients on new antiepileptic drugsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion: Oxcarbazepine and topiramate might cause hyper-tHcy, most likely because of the capacity of these agents to induce the hepatic enzymes. Because literature data suggest that hyper-tHcy may contribute to the development of cerebrovascular diseases and brain atrophy, a supplement of folate can be considered in these patients to normalize plasma tHcy. (Source: Epilepsia)
Source: Epilepsia - September 21, 2009 Category: Neurology Authors: Vincenzo Belcastro, Pasquale Striano, Gaetano Gorgone, Cinzia Costa, Clotilde Ciampa, Daniela Caccamo, Laura R. Pisani, Giancarla Oteri, Maria G. Marciani, Umberto Aguglia, Salvatore Striano, Riccardo Ientile, Paolo Calabresi, Francesco Pisani Source Type: journals

Neurological and Cardiovascular Adverse Events Associated with Antimanic Treatment in Children and Adolescents.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To identify the factors associated with incident neurological and cardiovascular adverse events in children and adolescents treated with antimanic agents, a retrospective, longitudinal study was conducted. Medicaid medical and pharmacy claims between January 1996 and December 2005 were used to identify 3657 children and adolescents prescribed antimanic medications, and a random sample of 4500 children not treated with psychotropic medications. All adverse events examined (sedation/drowsiness, headaches, involuntary movements/extrapyramidal symptoms (EPS), cardiovascular events, hypertension, and orthostatic hypotension...
Source: CNS Neuroscience and Therapeutics - September 20, 2009 Category: Neuroscience Authors: Jerrell JM Tags: CNS Neurosci Ther Source Type: journals

Modulation of antioxidant defence system in brain of rainbow trout (Oncorhynchus mykiss) after chronic carbamazepine treatment.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We investigated the effect of long-term exposure to CBZ on the antioxidant system in brain tissue of rainbow trout. Fish were exposed to sublethal concentrations of CBZ (1.0mug/L, 0.2mg/L or 2.0mg/L) for 7, 21, and 42days. Oxidative stress indices (LPO and CP) and activities of antioxidant enzymes (SOD, CAT, GPx and GR) in fish brain were measured. In addition, non-enzymatic antioxidant (GSH) was determined after 42days exposure. Carbamazepine exposure at 0.2mg/L led to significant increases (p<0.05) of LPO and CP after 42days and, at 2.0mg/L, after 21days. Activities of the antioxidant enzymes SOD, CAT, and GPx in ...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - September 20, 2009 Category: Biochemistry Authors: Li ZH, Zlabek V, Velisek J, Grabic R, Machova J, Randak T Tags: Comp Biochem Physiol C Toxicol Pharmacol Source Type: journals

Catastrophic antiphospholipid syndrome in a patient with Down syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a patient with Down syndrome, under treatment with carbamazepine, levopromazine and clonazepam. After urinary infection he developed glans necrosis requiring excision of prepuce. Six hours post surgery he presented right-hand ischemia followed by arterial and venous thrombosis of the right thoracic extremity. Later, he progressed to a compartment syndrome and presented ischemia of toes. All the clinical manifestations developed over a week. Anticardiolipin (aCL) antibodies, lupus anticoagulant and perinuclear antineutrophil antibodies were positive. Anticoagulant and immunosuppressive treatment were initiated. Ow...
Source: Lupus - September 19, 2009 Category: Rheumatology Authors: Medina G, Calleja C, Morán M, Vera-Lastra O, Jara LJ Tags: Lupus Source Type: journals

Is the brain arachidonic acid cascade a common target of drugs used to manage bipolar disorder?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although lithium has been used therapeutically to treat patients with bipolar disorder for over 50 years, its mechanism of action, as well as that of other drugs used to treat bipolar disorder, is not agreed upon. In the present paper, I review studies in unanaesthetized rats using a neuropharmacological approach, combined with kinetic, biochemical and molecular biology techniques, demonstrating that chronic administration of three commonly used mood stabilizers (lithium, valproic acid and carbamazepine), at therapeutically relevant doses, selectively target the brain arachidonic acid cascade. Upon chronic administrati...
Source: Biochemical Society Transactions - September 18, 2009 Category: Biochemistry Authors: Bazinet RP Tags: Biochem Soc Trans Source Type: journals