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Diabetes and hypertension markedly increased the risk of ischemic stroke associated with high serum resistin concentration in a general Japanese population: the Hisayama StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Resistin, secreted from adipocytes, causes insulin resistance in mice. The relationship between resistin and coronary artery disease is highly controversial, and the information regarding resistin and ischemic stroke is limited. In the present study, the association between serum resistin concentration and cardiovascular disease (CVD) was investigated in a general Japanese population. Methods: A total of 3,201 community-dwelling individuals aged 40 years or older (1,382 men and 1,819 women) were divided into quintiles of serum resistin, and the association between resistin and CVD was examined cross-sectionally...
Source: Cardiovascular Diabetology - November 18, 2009 Category: Cardiology Authors: Haruhiko OsawaYasufumi DoiHideichi MakinoToshiharu NinomiyaKoji YonemotoRyoichi KawamuraJun HataYumihiro TanizakiMitsuo IidaYutaka Kiyohara Source Type: journals

Elevated plasma levels of TNF-alpha and Interleukin-6 in patients with diastolic dysfunction and glucose metabolism disordersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This study reveals that increased plasma levels of IL-6 and TNF-alpha were associated with LVDD. These findings suggest a link between low-grade inflammation and the presence of LVDD. An active proinflammatory process may be of importance in the pathogenesis of diastolic dysfunction. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 12, 2009 Category: Cardiology Authors: Wilfried DinhReiner FuthWerner NicklThomas KrahnPeter EllinghausThomas ScheffoldLars BansemirAlexander BufeM. Coll BarrosoMark Lankisch Source Type: journals

Cardiovascular risk factors in Assyrians/Syrians and native Swedes with type 2 diabetes: a population-based epidemiological studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Swedish-born subjects had higher prevalence of increased triglycerides and hypertension than Assyrians/Syrians. Total cholesterol and HbA1c did not differ between the two ethnic groups. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - November 12, 2009 Category: Cardiology Authors: Marina TaloyanAlexandre WajngotSven-Erik JohanssonJonas ToviJan Sundquist Source Type: journals

Nitric oxide and superoxide dismutase modulate endothelial progenitor cell function in type 2 diabetes mellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our data provide evidence that SOD may play an essential role in EPCs, and emphasize the important role of antioxidant therapy in type 2 diabetic patients. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 30, 2009 Category: Cardiology Authors: Saher HamedBenjamin BrennerAnat AharonDeeb DaoudAriel Roguin Source Type: journals

Lack of benefits for prevention of cardiovascular disease with aspirin therapy in type 2 diabetic patients - a longitudinal observational studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study examined the benefit and harm of low-dose aspirin (daily dose (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 30, 2009 Category: Cardiology Authors: Wilson LeungWing-yee SoDerek StewartAugustine LuiPeter TongGary KoAlice KongRonald MaFrancis ChanXilin YangSau-Chu ChiangJuliana Chan Source Type: journals

Elevated resting heart rate is associated with the metabolic syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Increased resting heart rate (RHR) may be associated with increased cardiovascular morbidity. Our aim was to explore the possibility that increased RHR is associated with the prevalence of the metabolic syndrome (MetS) in a sample of apparently healthy individuals and those with cardiovascular risk factors. Methods: We performed a cross-sectional analysis in a large sample of apparently healthy individuals who attended a general health screening program and agreed to participate in our survey. We analyzed a sample of 7706 individuals (5106 men and 2600 women) with 13.2% of men and 8.9% of the women fulfilling t...
Source: Cardiovascular Diabetology - October 13, 2009 Category: Cardiology Authors: Ori RogowskiArie SteinvilShlomo BerlinerMichael CohenNili SaarOrit Kliuk Ben-BassatItzhak Shapira Source Type: journals

Network of vascular diseases, death and biochemical characteristics in a set of 4,197 patients with type 1 diabetes (The FinnDiane Study)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The complex pattern of links between diverse characteristics and the lack of a single dominant factor suggests a need for multifactorial and multidisciplinary paradigms for the research, treatment and prevention of diabetic complications. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - October 5, 2009 Category: Cardiology Authors: Ville-Petteri MakinenCarol ForsblomLena ThornJohan WadenKimmo KaskiMika Ala-KorpelaPer-Henrik Groop Source Type: journals

Prevalence of the Metabolic Syndrome in Latin America and its association with sub-clinical carotid atherosclerosis: the CARMELA cross sectional studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The prevalence of metabolic syndrome and its components by NCEP ATP III criteria was substantial across cities, ranging from 14% to 27%. CARMELA findings, including evidence of the association of metabolic syndrome and carotid atherosclerosis, should inform appropriate clinical and public health interventions. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 25, 2009 Category: Cardiology Authors: Jorge EscobedoHerman SchargrodskyBeatriz ChampagneHonorio SilvaCarlos BoissonnetRaul VinuezaMarta TorresRafael HernandezElinor Wilson Source Type: journals

Incremental cardiovascular costs and resource use associated with diabetes: an assessment of 29,863 patients in the US managed-care settingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Patients with type 2 diabetes are at increased risk of cardiovascular events, and there is an associated economic burden attached to this risk. We conducted a retrospective claims database analysis to evaluate incremental cardiovascular costs in diabetic versus non-diabetic patients hospitalized for a cardiovascular event. Methods: Patients hospitalized for a cardiovascular event between January 1, 2001 and June 30, 2005 were identified from a large US managed-care population. Diabetic patients were identified by evidence of type 2 diabetes in the 12 months prior to the index hospitalization. Direct medical cos...
Source: Cardiovascular Diabetology - September 25, 2009 Category: Cardiology Authors: Robert StrakaLarry LiuPrafulla GiraseAllyson DeLorenzoRichard Chapman Source Type: journals

Blood pressure control and components of the metabolic syndrome: the GOOD surveyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Among the components of the metabolic syndrome, it is not impaired glucose tolerance which is associated with the poor response to antihypertensive treatment. Instead, visceral obesity and dyslipidemia components of the metabolic syndrome, i.e. hypertriglyceridemia and low HDL cholesterol levels, are associated with resistance to antihypertensive treatment. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 14, 2009 Category: Cardiology Authors: Walter ZidekLisa Naditch-BruleStefano PerliniCsaba FarsangSverre Kjeldsen Source Type: journals

MMP-1 serum levels predict coronary atherosclerosis in humansEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Myocardial infarction results as a consequence of atherosclerotic plaque rupture, with plaque stability largely depending on the lesion forming extracellular matrix components. Lipid enriched non-calcified lesions are considered more instable and rupture prone than calcified lesions. Matrix metalloproteinases (MMPs) are extracellular matrix degrading enzymes with plaque destabilisating characteristics which have been implicated in atherogenesis. We therefore hypothesised MMP-1 and MMP-9 serum levels to be associated with non-calcified lesions as determined by CT-angiography in patients with coronary artery dise...
Source: Cardiovascular Diabetology - September 13, 2009 Category: Cardiology Authors: Michael LehrkeMartin GreifUli BroedlCorinna LebherzRudiger LaubenderAlexander BeckerFranz von ZieglerJanine TittusMaximilian ReiserChristoph BeckerBurkhard GoekeGerhard SteinbeckAlexander LeberKlaus Parhofer Source Type: journals

Pioglitazone enhances collateral blood flow in ischemic hindlimb of diabetic mice through an Akt-dependent VEGF-mediated mechanism, regardless of PPAR-gamma stimulationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These data demonstrate that Akt-VEGF pathway is essential for ischemia-induced angiogenic effect of pioglitazone and that pioglitazone exerts this effect via a PPAR-gamma independent manner. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - September 7, 2009 Category: Cardiology Authors: Federico BiscettiGiuseppe StrafaceVincenzo ArenaEgidio StiglianoGiovanni PecoriniPaola RizzoGiulia De AngelisLuigi IulianoGiovanni GhirlandaAndrea Flex Source Type: journals

Hemostatic risk factors in patients with coronary artery disease and type 2 diabetes - a two year follow-up of 243 patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
BackgoundThrombosis is regarded to be a key factor in the development of acute coronary syndromes in patients with coronary artery disease (CAD). We hypothesize, that hemostatic and rheological risk factors may be of major relevance for the incidence and the risk stratification of these patients. Methods: In 243 patients with coronary artery disease and stable angina pectoris parameters of metabolism, hemostasis, blood rheology and endogenous fibrinolysis were assessed. Patients were prospectively followed for 2 years in respect to elective revascularizations and acute coronary syndromes. Results: During follow-up 88 patie...
Source: Cardiovascular Diabetology - September 6, 2009 Category: Cardiology Authors: Thomas JaxAnsgar PetersGunnar PlehnFrank-Chris Schoebel Source Type: journals

Folic acid supplementation normalizes the endothelial progenitor cell transcriptome of patients with type 1 diabetes: a case-control pilot studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Folic acid normalizes endothelial progenitor cell gene expression profiles of patients with type 1 diabetes. Signaling pathways modulated by folic acid may be potential therapeutic targets to improve endothelial progenitor cell function. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 24, 2009 Category: Cardiology Authors: Olivia van OostromDominique de KleijnJoost FledderusMario PescatoriAndrew StubbsAttie TuinenburgSai-Kiang LimMarianne Verhaar Source Type: journals

Changes in cultured endothelial cell glycosaminoglycans under hyperglycemic conditions and the effect of insulin and heparinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: High glucose and insulin alone reduces endothelial GAGs. In hyperglycemic conditions, heparin or insulin preserves GAGs which may protect cells from injury. Insulin is an effective diabetic therapy since it not only lowers blood glucose, but also protects endothelium. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 19, 2009 Category: Cardiology Authors: Juying HanFuming ZhangJin XieRobert LinhardtLinda Hiebert Source Type: journals

Association between carotid diameter and the advanced glycation endproduct Nepsilon-Carboxymethyllysine (CML)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Nepsilon-Carboxymethyllysine (CML) is the major non-cross linking advanced glycation end product (AGE). CML is elevated in diabetic patients and apparent in atherosclerotic lesions. AGEs are associated with hypertension and arterial stiffness potentially by qualitative changes of elastic fibers. We investigated whether CML affects carotid and aortic properties in normoglycemic subjects. Methods: Ninety-two subjects (age 47.6 +/-.11.0 years) of the FLEMENGHO study were stratified according to the median of the plasma CML level (201.5 ng/ml; 25th percentile: 183.6ng/ml, 75th percentile: 227.4ng/ml) into "high CML...
Source: Cardiovascular Diabetology - August 5, 2009 Category: Cardiology Authors: Marcus BaumannTom RichartDaniel SollingerJaroslav PelisekMarcel RoosTatiana KouznetsovaHans-Henning EcksteinUwe HeemannJan Staessen Source Type: journals

Visceral fat dominant distribution in male type 2 diabetic patients is closely related to hepatic insulin resistance, irrespective of body typeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: We conclude that, independent of the individual's body type, visceral fat dominant accumulation as opposed to subcutaneous fat accumulation is associated with hepatic insulin resistance, whereas peripheral (muscle) insulin resistance is more closely related to general obesity (i.e. higher BMI and total FM, and increased abdominal SF and VF) in male patients with type 2 diabetes. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - August 4, 2009 Category: Cardiology Authors: Yoshinori MiyazakiRalph DeFronzo Source Type: journals

Cardiomyopathy in offspring of diabetic rats is associated with activation of the MAPK and apoptotic pathwaysEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The degree of maternal hyperglycemia determines the type of cardiomyopathy seen in the offspring, while resolution of both the hypertrophic and dilated cardiomyopathies is associated with activation of MAPK signaling and apoptotic pathways. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 30, 2009 Category: Cardiology Authors: Benjamin ReinkingElesa WedemeyerRobert WeissJeffrey SegarThomas Scholz Source Type: journals

Different modulation by dietary restriction of adipokine expression in white adipose tissue sites in the ratEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Food restriction induced different patterns for mesenteric and the other WAT sites, which may be directly related to both the response to intestine-derived energy availability, and an inflammatory-related response. However, retroperitoneal WAT, and to a lower extent, subcutaneous and epididymal, reacted decreasing the expression of inflammatory markers and the signaling of decreased energy availability in their stores. The varying cytokine expression patterns highlight the fact that WAT sites show different inflammatory and signaling responses to energy availability; they are too much different to simply exten...
Source: Cardiovascular Diabetology - July 29, 2009 Category: Cardiology Authors: Maria del Mar RomeroJose Antonio Fernandez-LopezMontserrat EsteveMaria Alemany Source Type: journals

The role of glucose lowering agents on restenosis after percutaneous coronary intervention in patients with diabetes mellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Several glucose lowering agents have been shown to influence the restenosis process and thus the outcome after PCI. Current data of especially metformin and thiazolidinediones indicate beneficial results as compared to insulin and sulfonylurea on restenosis. However, no large trials have been undertaken in which the effect of glucose lowering agents on restenosis is associated with improved outcome.The purpose of this review is to summarize the effect of diabetes and glucose lowering agents on restenosis. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 27, 2009 Category: Cardiology Authors: Chris LexisBraim RahelJoan MeederFelix ZijlstraIwan van der Horst Source Type: journals

Lay media reporting of rosiglitazone risk: extent, messaging and quality of reportingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: There were many lay media articles addressing the safety of rosiglitazone, and the general messaging of these articles was considered "worrisome" by reviewers. Quality of risk reporting in the articles reviewed was poor. The impact of such media coverage on public anxiety and confidence in treatment should be explored. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 23, 2009 Category: Cardiology Authors: Doreen RabiAdriane LewinGarielle BrownAlun EdwardsJeffrey JohnsonWilliam Ghali Source Type: journals

Altered myocardial substrate metabolism is associated with myocardial dysfunction in early diabetic cardiomyopathy in rats: studies using positron emission tomographyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: In vitro data suggest that changes in myocardial substrate metabolism may contribute to impaired myocardial function in diabetic cardiomyopathy (DCM). The purpose of the present study was to study in a rat model of early DCM, in vivo changes in myocardial substrate metabolism and their association with myocardial function. Methods: Zucker diabetic fatty (ZDF) and Zucker lean (ZL) rats underwent echocardiography followed by [11C]palmitate positron emission tomography (PET) under fasting, and [18F]-2-fluoro-2-deoxy-D-glucose PET under hyperinsulinaemic euglycaemic clamp conditions. Isolated cardiomyocytes were us...
Source: Cardiovascular Diabetology - July 21, 2009 Category: Cardiology Authors: Charissa van den BromMarc HuismanRonald VlasblomNicky BoontjeSuzanne DuijstMark LubberinkCarla MolthoffAdriaan LammertsmaJolanda van der VeldenChrista BoerD.Margriet OuwensMichaela Diamant Source Type: journals

Biliary pancreatic diversion and laparoscopic adjustable gastric banding in morbid obesity: their long-term effects on metabolic syndrome and cardiovascular parametersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These data indicate that BPD, likely due to a greater BMI decrease, is more effective than LAGB in improving cardiovascular parameters, and similar to LAGB on metabolic parameters, in obese patients. The greater effect on cholesterol levels is probably due to the different mechanism of action. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 19, 2009 Category: Cardiology Authors: Antonio PontiroliMarco LaneriAnnamaria VeronelliFrancesca FrigeGiancarlo MichelettoFranco FolliGianfranco AdamiNicola Scopinaro Source Type: journals

A cardiologic approach to non-insulin antidiabetic pharmacotherapy in patients with heart diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Classical non-insulin antihyperglycemic drugs currently approved for the treatment of type 2 diabetes mellitus (T2DM) comprise five groups: biguanides, sulfonylureas, meglitinides, glitazones and alpha-glucosidase inhibitors. Novel compounds are represented by the incretin mimetic drugs like glucagon like peptide-1 (GLP-1), the dipeptidyl peptidase 4 (DPP-4) inhibitors, dual peroxisome proliferator-activated receptors (PPAR) agonists (glitazars) and amylin mimetic drugs. We review the cardiovascular effects of these drugs in an attempt to improve knowledge regarding their potential risks when treating T2DM in cardiac patie...
Source: Cardiovascular Diabetology - July 19, 2009 Category: Cardiology Authors: Enrique FismanAlexander Tenenbaum Source Type: journals

A randomized controlled trial on the efficacy of carbohydrate-reduced or fat-reduced diets in patients attending a telemedically guided weight loss programEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: We investigated whether macronutrient composition of energy-restricted diets influences the efficacy of a telemedically guided weight loss program. Methods: Two hundred overweight subjects were randomly assigned to a conventional low-fat diet and a low-carbohydrate diet group (target carbohydrate content: >55% energy and (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 17, 2009 Category: Cardiology Authors: Sabine FrischArmin ZittermannHeiner BertholdChristian GottingJoachim KuhnKnut KleesiekPeter StehleHeinrich Kortke Source Type: journals

Beneficial effects of a Paleolithic diet on cardiovascular risk factors in type 2 diabetes: a randomized cross-over pilot studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Over a 3-month study period, a Paleolithic diet improved glycemic control and several cardiovascular risk factors compared to a Diabetes diet in patients with type 2 diabetes.Trial registrationClinicalTrials.gov NCT00435240. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - July 15, 2009 Category: Cardiology Authors: Tommy JonssonYvonne GranfeldtBo AhrenUlla-Carin BranellGunvor PalssonAnita HanssonMargareta SoderstromStaffan Lindeberg Source Type: journals

Divergent fifteen-year trends in traditional and cardiometabolic risk factors of cardiovascular diseases in the SeychellesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ObjectiveFew studies have assessed secular changes in the levels of cardiovascular risk factors (CV-RF) in populations of low or middle income countries. The systematic collection of a broad set of both traditional and metabolic CV-RF in 1989 and 2004 in the population of the Seychelles islands provides a unique opportunity to examine trends at a fairly early stage of the "diabesity" era in a country in the African region. Methods: Two examination surveys were conducted in independent random samples of the population aged 25-64 years in 1989 and 2004, attended by respectively 1081 and 1255 participants (participation rates...
Source: Cardiovascular Diabetology - June 25, 2009 Category: Cardiology Authors: Pascal BovetSarah RomainConrad ShamlayeShanthi MendisRoger DarioliWalter RiesenLuc TappyFred Paccaud Source Type: journals

Combined effects of obesity and type 2 diabetes contribute to increased breast cancer risk in premenopausal womenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Obesity and type 2 diabetes, owing to their effects on adipocytokines and inflammatory mediators, contribute to increased breast cancer risk in premenopausal women. This study emphasizes healthy life style and better management of these metabolic disorders to avoid the pathogenesis of breast cancer and of other chronic diseases. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 22, 2009 Category: Cardiology Authors: Majed AlokailNasser Al-DaghriOmar Al-AttasTajamul Hussain Source Type: journals

Losartan counteracts the hyper-reactivity to angiotensin II and ROCK1 over-activation in aortas isolated from streptozotocin-injected diabetic ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions and implicationsAortas isolated from STZ-rats present hyper-contracture to AT-II mainly dependent on the up-regulation of ROCK1 expression/activity. In vivo losartan treatment partially corrects AT-II hyper-contracture, limiting the increase in ROCK1 expression/activity. These data offer a new molecular mechanism supporting the rationale for using losartan in the prevention of diabetic vascular complications. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 21, 2009 Category: Cardiology Authors: Paola FailliChiara AlfaranoSergio Franchi-MicheliEdoardo MannucciElisabetta CerbaiAlessandro MugelliLaura Raimondi Source Type: journals

The common G-866A polymorphism of the UCP2 gene and survival in diabetic patients following myocardial infarctionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: A variant in the promoter of the human uncoupling protein 2 (UCP2) gene, the G-866A polymorphism, has been associated with future risk of coronary heart disease events, in those devoid of traditional risk factors and in those suffering from diabetes. We thus examined the impact of the G-866A polymorphism on 5-year survival in a cohort of 901 post-myocardial infarction patients, and the impact of type-2 diabetes on this relationship. The association of UCP2 with baseline biochemical and hormonal measurements, including levels of the inflammatory marker myeloperoxidase, was also examined. Methods: UCP2 G-866A ge...
Source: Cardiovascular Diabetology - June 15, 2009 Category: Cardiology Authors: Barry PalmerCourtney DevereauxSukhbir DhamraitTessa MocattaAnna PilbrowChris FramptonLorraine SkeltonTim YandleChristine WinterbournA RichardsHugh MontgomeryVicky Cameron Source Type: journals

Changes in body mass index, leptin and adiponectin in Japanese children during a three-year follow-up period: a population-based cohort studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ObjectiveThe study examined changes in and relationship between body mass index (BMI), leptin and adiponectin levels over a 3-year period in a pediatric population-based cohort.Study design: A 3-year prospective cohort study of 268 boys and 251 girls aged 9-10 in Ina, Saitama, Japan. Results: Median body mass index (BMI) significantly increased from baseline (age 9-10) to follow up (age 12-13) in boys from 17.1 to 18.3 kg/m2 (P < 0.001) and in girls from 16.5 to 18.5 kg/m2 (P < 0.001), respectively. Adiponectin values significantly decreased from baseline to follow up in boys (13.5 to 8.9 ug/ml, respectively) (P < 0.001) a...
Source: Cardiovascular Diabetology - June 3, 2009 Category: Cardiology Authors: Rimei NishimuraHironari SanoToru MatsudairaAya MorimotoYumi MiyashitaTakako ShirasawaAkatsuki KokazeNaoko Tajima Source Type: journals

HNF1A gene variants and cardiovascular risk factors in individuals with late-onset autosomal dominant diabetes: a cross-sectional studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Late onset autosomal dominant diabetes mellitus is clinically indistinguishable from classical type 2 diabetes individuals. However, LOADDM group is enriched for common HNF1A polymorphisms A98V and S487N. I27L showed "protective effect" upon hypertriglyceridemia in these sample of individuals, suggesting a role for HNF1A on diabetic individuals' lipid profile. These data contribute to the understanding of the complex interactions between genes, hyperglycemia and cardiovascular risk factors development in type 2 diabetes mellitus. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 2, 2009 Category: Cardiology Authors: Fernando GiuffridaGilberto FuruzawaTeresa KasamatsuMarcos OliveiraAndre ReisSergio Dib Source Type: journals

Haptoglobin genotype is a determinant of survival and cardiac remodeling after myocardial infarction in diabetic miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In DM mice the Hp 2-2 genotype is associated with increased mortality and more severe cardiac remodeling 30 days after MI. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - June 2, 2009 Category: Cardiology Authors: Roy AsafShany BlumAriel RoguinShiri Kalet-LitmanJad KheirAvi FrischRachel Miller-LotanAndrew Levy Source Type: journals

A study of endothelial function and circulating asymmetric dimethylarginine levels in people with Type 1 diabetes without macrovascular disease or microalbuminuriaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Asymmetric dimethylarginine (ADMA) is a competitive inhibitor of endothelial nitric oxide synthase (eNOS) that is associated with endothelial dysfunction, and is a risk marker for cardiovascular disease, a significant problem in Type 1 diabetes. The aim of the present study was to measure circulating ADMA, and define its association with endothelial dysfunction and endothelial markers in people with Type 1 diabetes with low likelihood of macrovascular disease. Methods: Sixty-one young people with Type 1 diabetes without macrovascular disease or nephropathy and 62 healthy volunteers underwent brachial artery flo...
Source: Cardiovascular Diabetology - June 1, 2009 Category: Cardiology Authors: Latika SibalSharad AgarwalEdzard SchwedhelmNicole LuneburgRainer BogerPhilip Home Source Type: journals

Dyslipidemia treatment of patients with diabetes mellitus in a US managed care plan: a retrospective database analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Over 40% of DM patients with mixed dyslipidemia received no lipid-modifying therapy during the follow-up period. Those who were treated were primarily prescribed statin monotherapy. This study suggests that DM patients are not being treated to ADA-suggested targets. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 18, 2009 Category: Cardiology Authors: Peter P Toth, Victoria Zarotsky, Jane M Sullivan and Dave Laitinen Source Type: journals

Patterns and predictors of statin prescription in patients with type 2 diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The majority of patients with type 2 diabetes are not receiving statins. The predominant factors determining statin prescription are the patient's prevention status and, in primary prevention, estimated cardiovascular risk. The results suggest that although physicians are aware of the general concept of cardiovascular risk, they fail to consistently implement guidelines. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - May 13, 2009 Category: Cardiology Authors: Heiner K. Berthold, Ioanna Gouni-Berthold, Michael Bohm, Wilhelm Krone and Kurt P. Bestehorn Source Type: journals

Relevance of hemostatic risk factors on coronary morphology in patients with diabetes mellitus type 2Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ObjectiveThe influence hemostatitc parameters on the morphological extent and severity of coronary artery disease were studied in patients with and without DM type 2. Background: It is known that patients with diabetes (DM) have abnormal metabolic and hemostatic parameters Methods: Of 150 consecutive patients with angiographically proven coronary artery disease 29 presented with DM. Additionally to parameters of lipid-metabolism fibrinogen, tissue-plasminogenactivator (t-PA), plasminogen-activator-inhibitor (PAI), plasmin-a-antiplasmin (PAP), prothrombin-fragment 1+2 (F1+2), thrombin-antithrombin (TAT), von-willebrand-fac...
Source: Cardiovascular Diabetology - May 6, 2009 Category: Cardiology Authors: Thomas W Jax, Ansgar J Peters, Gunnar Plehn and Frank-Chris Schoebel Source Type: journals

Postprandial hyperglycemia as an etiological factor in vascular failureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Postprandial hyperglycemia is characterized by hyperglycemic spikes that induce endothelial dysfunction, inflammatory reactions and oxidative stress, which may lead to progression of atherosclerosis and occurrence of cardiovascular events. Emerging data indicate that postprandial hyperglycemia or even impaired glucose tolerance may predispose to progression of atherosclerosis and cardiovascular events. There is evidence that postprandial hyperglycemia, but not fasting hyperglycemia, independently predicts the occurrence of cardiovascular events. We proposed a concept of 'vascular failure' as a comprehensive syndrome of vas...
Source: Cardiovascular Diabetology - April 29, 2009 Category: Cardiology Authors: Koichi Node and Teruo Inoue Source Type: journals

Predictive models of insulin resistance derived from simple morphometric and biochemical indices related to obesity and the metabolic syndrome in baboonsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In baboons, simple morphometric measurements of adiposity/obesity, (i.e. abdominal circumference), plus baseline markers of glucose/lipid metabolism, (i.e. fasting plasma glucose and insulin) provide a feasible method to screen and identify overweight/obese insulin resistant baboons for inclusion in interventional studies aimed to study human obesity, insulin resistance and type 2 diabetes mellitus. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 23, 2009 Category: Cardiology Authors: Alberto O Chavez, Amalia Gastaldelli, Rodolfo Guardado-Mendoza, Juan C Lopez-Alvarenga, M Michelle Leland, M Elizabeth Tejero, GianPio Sorice, Francesca Casiraghi, Alberto Davalli, Raúl A Bastarrachea, Anthony G Comuzzie, Ralph A DeFronzo and Franco Foll Source Type: journals

Predictive models of insulin resistance derived from simple morphometric and biochemical indices related to obesity and the metabolic syndrome in baboons.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Non-human primates are valuable models for the study of insulin resistance and human obesity. In baboons, insulin sensitivity levels can be evaluated directly with the euglycemic clamp and is highly predicted by adiposity, metabolic markers of obesity and impaired glucose metabolism (i.e. percent body fat by DXA and HbA1c). However, a simple method to screen and identify lean insulin sensitive as well as obese insulin resistant baboons for inclusion in interventional studies is not available. Methods: We studied a population of twenty baboons (10 males and 10 females) with the euglycemic clamp technique to cha...
Source: Cardiovascular Diabetology - April 23, 2009 Category: Cardiology Authors: Alberto O Chavez, Amalia Gastaldelli, Rodolfo Guardado-Mendoza, Juan C Lopez-Alvarenga, M.Michelle Leland, M. Elizabeth Tejero, GianPio Sorice, Francesca Casiraghi, Alberto M Davalli, Raul A Bastarrachea, Anthony G Comuzzie, Ralph A DeFronzo and Franco Fo Source Type: journals

Associations of cardiovascular risk factors in Al Ain- United Arab EmiratesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In this population risk-factors cluster, but associations do not appear to be explained by the presence/absence of the ATP-III metabolic syndrome. Associations provide valuable information in planning interventions for screening and management. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - April 16, 2009 Category: Cardiology Authors: Latifa M Baynouna, Anthony D Revel, Nico JD Nagelkerke, Tariq M Jaber, Aziza O Omer, Nader M Ahmed, Mohammad K Naziruldeen, Mamdouh F Al Sayed, Fouad A Nour and Sameh Abdouni Source Type: journals

Changes in endotoxin levels in T2DM subjects on anti-diabetic therapiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
IntroductionChronic low-grade inflammation is a significant factor in the development of obesity associated diabetes. This is supported by recent studies suggesting endotoxin, derived from gut flora, may be key to the development of inflammation by stimulating the secretion of an adverse cytokine profile from adipose tissue. AimsThe study investigated the relationship between endotoxin and various metabolic parameters of diabetic patients to determine if anti-diabetic therapies exerted a significant effect on endotoxin levels and adipocytokine profiles. Methods: Fasting blood samples were collected from consenting Saudi Ar...
Source: Cardiovascular Diabetology - April 15, 2009 Category: Cardiology Authors: Omar S Al-attas, Nasser M Al-Daghri, Khalid A Al-Rubeaan, Nancy F da Silva, Shaun L Sabico, Sudhesh Kumar, Philip G McTernan and Alison L Harte Source Type: journals

Improvement of the diabetic foot upon testosterone administration to hypogonadal men with peripheral arterial disease. Report of three casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Beneficial effects of administration of testosterone to hypogonadal with a diabetic foot may be due to improved vascularization and to anti-inflammatory action. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 28, 2009 Category: Cardiology Authors: Svetlana Kalinchenko, Alexandr Zemlyanoy and Louis J Gooren Source Type: journals

Blood pressure reduction, persistence and costs in the evaluation of antihypertensive drug treatment - a reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: To evaluate drugs for the treatment of hypertension several key variables including the blood pressure lowering effect, side effects, compliance / persistence with treatment, as well as drug costs and direct and indirect costs of medical care have to be considered. ARBs, while nominally more expensive when drug costs are considered only, provide substantial cost savings and may prevent cardiovascular morbidity and mortality based on the more complete antihypertensive coverage. This make ARBs an attractive choice for long term treatment of hypertension. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 27, 2009 Category: Cardiology Authors: Peter Bramlage and Joerg Hasford Source Type: journals

Diabetic cardiomyopathy: effects of fenofibrate and metformin in an experimental model – the Zucker diabetic ratEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Fenofibrate had favourable actions on DCM. Metformin had beneficial effect on TAG content but not on fibrosis. PPARα agonists could be useful for the prevention and treatment of DCM. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 24, 2009 Category: Cardiology Authors: Fabien Forcheron, Alexandra Basset, Pauline Abdallah, Peggy Del Carmine, Nicolas Gadot and Michel Beylot Source Type: journals

Diabetic cardiomyopathy :effects of fenofibrate and meformin in an experimental model - the Zucker diabetic ratEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Fenofibrate had favourable actions on DCM. Metformin had beneficial effect on TAG content but not on fibrosis. PPARa agonists could be useful for the prevention and treatment of DCM. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 24, 2009 Category: Cardiology Authors: Fabien Forcheron, Alexandra Basset, Pauline Abdallah, Peggy Del Carmine, Nicolas Gadot and Michel Beylot Source Type: journals

The impact of diabetes on coronary heart disease differs from that on ischaemic stroke with regard to the genderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions CHD risk was higher in men than in women but difference reduced in diabetic population. Diabetes, however, increased stroke risk more in men than in women. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 24, 2009 Category: Cardiology Authors: Marjukka Hyvarinen, Jaakko Tuomilehto, Tiina Laatikainen, Stefan Soderberg, Mats Eliasson, Peter Nilsson and Qing Qiao Source Type: journals

Effect of pioglitazone versus insulin glargine on cardiac size, function, and measures of fluid retention in patients with type 2 diabetesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Both insulin and thiazolidinediones (TZDs) are effective in the treatment of hyperglycaemia and amelioration of insulin resistance in type 2 diabetes but have side effects including weight gain and fluid retention. The use of TZDs has been further hampered by the risk of adverse cardiovascular events including heart failure. The present study evaluated the effect of pioglitazone or insulin glargine on cardiac function and size as well as on surrogate markers of fluid retention such as weight, haemoglobin and natriuretic peptides. Methods: Thirty patients with inadequate glycaemic control on metformin and sulfon...
Source: Cardiovascular Diabetology - March 20, 2009 Category: Cardiology Authors: Mozhgan Dorkhan, Magnus Dencker, Martin Stagmo and Leif Groop Source Type: journals

ACE I/D genotype, adiposity, and blood pressure in childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Angiotensin converting enzyme (ACE) is a possible candidate gene that may influence both body fatness and blood pressure. Although several genetic studies have been conducted in adults, relatively few studies have examined the contribution of potential candidate genes, and specifically ACE I/D, on adiposity and BP phenotypes in childhood. Such studies may prove insightful for the development of the obesity-hypertension phenotype early in life. The purpose of this study was to examine differences in body fatness and resting blood pressure (BP) by ACE I/D genotype, and determine if the association between adiposi...
Source: Cardiovascular Diabetology - March 16, 2009 Category: Cardiology Authors: Joey C Eisenmann, Mark A Sarzynski, Kim Glenn, Max Rothschild and Kate A Heelan Source Type: journals

Long-term outcomes in patients with type 2 diabetes receiving glimepiride combined with liraglutide or rosiglitazoneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Using data from LEAD-1 and epidemiologic evidence from the CORE diabetes model, projected rates of mortality, diabetes complications and healthcare costs over the long term favor liraglutide plus glimepiride over rosiglitazone plus glimepiride. Trial registration: LEAD-1 NCT00318422; LEAD-2 NCT00318461; LEAD-3 NCT 00294723; LEAD-4 NCT00333151; LEAD-5 NCT00331851; LEAD-6 NCT00518882. (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - February 26, 2009 Category: Cardiology Authors: Sean D Sullivan, Rafael Alfonso-Cristancho, Chris Conner, Mette Hammer and Lawrence Blonde Source Type: journals