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Protective Effects of Lycopene against H2O2-Induced Oxidative Injury and Apoptosis in Human Endothelial CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Lycopene can decrease the oxidative injury of endothelial cells induced by H2O2, can attenuate the expression of p53 and caspase-3 mRNA in injured cells, and can diminish the apoptosis of injured cells. These findings possibly explain in part why lycopene can prevent atherosclerotic cardiovascular diseases. Content Type Journal ArticleDOI 10.1007/s10557-009-6206-3Authors XiangYu Tang, Fujian Medical University and Fujian Provincial Institute of Coronary Disease Department of Cardiology, Union Hospital Fuzhou Fujian China 350001XiangDong Yang, University of South China Institute of cardiovas...
Source: Cardiovascular Drugs and Therapy - November 13, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

Oral Antiplatelet Therapy for Acute and Chronic Management of NSTE ACS: Residual Ischemic Risk and Opportunities for ImprovementEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion These considerations suggest that novel therapies with a different mechanism of action, when used in combination with current antiplatelet agents, may provide more comprehensive inhibition of platelet activation and additional reductions in morbidity and mortality, potentially without incremental bleeding risk. Content Type Journal ArticleDOI 10.1007/s10557-009-6204-5Authors Marc Cohen, Newark Beth Israel Medical Center Division of Cardiology 201 Lyons Avenue at Osborne Terrace Newark NJ 07112 USA Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Sour...
Source: Cardiovascular Drugs and Therapy - November 4, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

Anti-apoptotic Effects of a Calpain Inhibitor on Cardiomyocytes in a Canine Rapid Atrial Fibrillation ModelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The calpain inhibitor N-Acetyl-Leu-Leu-Met attenuated apoptosis through a complicated network of apoptosis-related proteins, which may result in improvement of structural remodeling in atrial fibrillation. Content Type Journal ArticleDOI 10.1007/s10557-009-6199-yAuthors Yue Li, Harbin Medical University Department of Cardiology, the First Affiliated Hospital Harbin 150001 People’s Republic of ChinaZhi-Hua Gong, Harbin Medical University Department of Cardiology, the First Affiliated Hospital Harbin 150001 People’s Republic of ChinaLi Sheng, Harbin Medical University Department of Cardio...
Source: Cardiovascular Drugs and Therapy - October 30, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

Erythropoiesis Stimulating Agents in Heart Failure Patients with Anemia: A Meta-AnalysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion In patients with heart failure and anemia, erythropoiesis stimulating agent therapy appears to have a positive effect on several important cardiovascular parameters, compared to control therapy. Large prospective randomized controlled trials are warranted to comprehensively evaluate the potential effects of erythropoiesis stimulating agents on clinical outcomes in heart failure patients with anemia. Content Type Journal ArticleDOI 10.1007/s10557-009-6203-6Authors Faramarz Tehrani, Cedars-Sinai Medical Center Cedars-Sinai Heart Institute 8700 Beverly Blvd, #5534 Los Angeles CA 90048 USAPavi...
Source: Cardiovascular Drugs and Therapy - October 27, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

Benefits and Difficulties in Measuring HDL Subfractions and Human Paraoxonase-1 Activity During Statin TreatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Dyslipidaemia including decreased high density lipoprotein cholesterol concentration is one of several factors that have been implicated in increased cardiovascular risk. Since their introduction in the 1980s, 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins) have emerged as the one of the best-selling class of medications to date, with numerous trials demonstrating powerful efficacy in preventing cardiovascular diseases. Although statins have been shown to modestly raise or not alter HDL-cholesterol, their effect on HDL subfractions and on HDL-associated enzymes includi...
Source: Cardiovascular Drugs and Therapy - October 26, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

A Clinical Puzzle: Fibrates and Homocysteine ElevationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory EditorialDOI 10.1007/s10557-009-6201-8Authors Michael H. Davidson, Radiant Research The University of Chicago Pritzker School of Medicine 515 North State Street, Suite 2700 Chicago IL 60654 USA Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - October 21, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

Statin Use is Associated with a Significant Reduction in Cholesterol Content of Erythrocyte Membranes. A Novel Pleiotropic Effect?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The present study showed, that use of statins is associated with a reduction in CEM, an emerging marker of clinical instability and plaque vulnerability in CAD patients. The pleiotropic effects of statins at the cell membrane level represent a promising novel direction for research in CAD. Content Type Journal ArticleDOI 10.1007/s10557-009-6202-7Authors Dimitrios N. Tziakas, Democritus University of Thrace University Cardiology Department, Medical School Voulgaroktonou 23 68100 Alexandroupolis GreeceGeorgios K. Chalikias, Democritus University of Thrace University Cardiology Department, Me...
Source: Cardiovascular Drugs and Therapy - October 16, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

Comparison of the Effects of Levosimendan and Papaverine on Human Internal Mammary Artery and Saphenous VeinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions It is concluded that levosimendan is much more potent to relax norepinephrine-induced contraction of human IMA in comparison to its effect on human SV. It may have the potential to be used as a mixed inotropic/arteriodilator compound in several clinical settings including CABG in which it can increase cardiac contractility and prevent IMA vasospasm. Content Type Journal ArticleDOI 10.1007/s10557-009-6197-0Authors Hossein Mirkhani, Shiraz University of Medical Sciences Department of Pharmacology PO Box 71345-1649 Shiraz IranMasih Shafa, Shiraz University of Medical Sciences Department of s...
Source: Cardiovascular Drugs and Therapy - October 13, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

Calpain in Atrial Fibrillation: Friend or Foe?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleDOI 10.1007/s10557-009-6200-9Authors Uwe Lendeckel, Ernst-Moritz-Arndt University Institute of Medical Biochemistry and Molecular Biology Greifswald GermanyAndreas Goette, Otto-von-Guericke University Division of Cardiology, University Hospital Magdeburg Germany Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - October 8, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

Resveratrol Supplementation Gender Independently Improves Endothelial Reactivity and Suppresses Superoxide Production in Healthy RatsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Our results suggest that resveratrol supplementation gender independently could improve the capacity of endothelial function and suppression of oxidative stress under physiological conditions. Resveratrol ingestion indicates a potential for cardiovascular health promotion. Content Type Journal ArticleDOI 10.1007/s10557-009-6198-zAuthors Selen Soylemez, Gazi University Department of Pharmacology, Faculty of Pharmacy Etiler, Ankara TurkeyAylin Sepici, Gazi University Department of Medical Biochemistry, Faculty of Medicine Besevler, Ankara TurkeyFatma Akar, Gazi University Department of Pharma...
Source: Cardiovascular Drugs and Therapy - October 7, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

Respiratory Effects of β-blocker Therapy in Heart FailureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, it is possible to use β-blockers in HF patients even in the presence of lung function impairment, but their use should be guided by a combination of lung function evaluation and knowledge of the pharmacological properties of each molecule Content Type Journal ArticleDOI 10.1007/s10557-009-6195-2Authors Piergiuseppe Agostoni, Università di Milano Centro Cardiologico Monzino-IRCCS, Istituto di Cardiologia via Parea 4 20138 Milan ItalyPietro Palermo, Università di Milano Centro Cardiologico Monzino-IRCCS, Istituto di Cardiologia via Parea 4 20138 Milan ItalyMauro Contini, Università di Milano Centro ...
Source: Cardiovascular Drugs and Therapy - September 29, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

Ischaemic Preconditioning and Postconditioning do not Affect Adenosine A1 and A2A Receptor SensitivityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s10557-009-6196-1Authors Niels P. Riksen, Radboud University Nijmegen Medical Centre Department of Vascular Medicine and Pharmacology-Toxicology Geert Grooteplein 21 PO Box 9101 6500 HB Nijmegen The NetherlandsAbigail Wynne, University College London Medical School The Hatter Cardiovascular Institute London UKDerek M. Yellon, University College London Medical School The Hatter Cardiovascular Institute London UKDerek J. Hausenloy, University College London Medical School The Hatter Cardiovascular Institute London UK Journal Cardiovascular Drugs...
Source: Cardiovascular Drugs and Therapy - September 29, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

President’s Page: Beijing 2009Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleDOI 10.1007/s10557-009-6193-4Authors Jay N. Cohn, University of Minnesota Medical School Cardiovascular Division, Mayo Mail Code 508 420 Delaware Street Southeast Minneapolis MN 55455 USA Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - September 24, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

Azelnidipine and Amlodipine Anti-Coronary Atherosclerosis Trial in Hypertensive Patients Undergoing Coronary Intervention by Serial Volumetric Intravascular Ultrasound Analysis in Juntendo University (ALPS-J)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions In this study, we will investigate the improvement of coronary plaque with IVUS by treatment with two dihydropyridine CCBs in hypertensive patients undergoing elective PCI. This result will lead to the discovery of more effective drug therapy for inhibition of coronary events. Content Type Journal ArticleDOI 10.1007/s10557-009-6192-5Authors Katsumi Miyauchi, Juntendo University School of Medicine Department of Cardiology Tokyo JapanTakahiko Kojima, Juntendo University School of Medicine Department of Cardiology Tokyo JapanTakayuki Yokoyama, Juntendo University School of Medicine Department...
Source: Cardiovascular Drugs and Therapy - September 17, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

Endothelial Cell Seeding Fails to Prevent Intimal Hyperplasia Following Arterial Injury in the Rat Carotid ModelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Endothelial cell seeding fails to prevent intimal hyperplasia following arterial injury in the rat carotid model. Content Type Journal ArticleDOI 10.1007/s10557-009-6191-6Authors Bertram J. Jobst, Regensburg University Medical Center Department of Internal Medicine II Franz-Josef-Strauß-Allee 11 Regensburg 93053 GermanyGuenter A. J. Riegger, Regensburg University Medical Center Department of Internal Medicine II Franz-Josef-Strauß-Allee 11 Regensburg 93053 GermanyDaniel P. Griese, Regensburg University Medical Center Department of Internal Medicine II Franz-Josef-Strauß-Allee 11 Regensburg...
Source: Cardiovascular Drugs and Therapy - September 17, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

How Can We Improve the Management of Vascular Risk in Type 2 Diabetes: Insights from FIELDEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Adding fenofibrate to primary statin therapy might be a useful strategy to address residual macrovascular and microvascular risk in type 2 diabetes. Content Type Journal ArticleDOI 10.1007/s10557-009-6190-7Authors George Steiner, University of Toronto Toronto General Hospital 200 Elizabeth Street Toronto ON M5G 2C4 Canada Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - September 16, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

Effect of Nebivolol and Atenolol on Brachial Artery Flow-Mediated Vasodilation in Patients with Coronary Artery DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory ErratumDOI 10.1007/s10557-009-6187-2Authors John P. Lekakis, Athens University Department of Clinical Therapeutics, Alexandra University Hospital Athens GreeceAthanassios Protogerou, Athens University Department of Clinical Therapeutics, Alexandra University Hospital Athens GreeceChristos Papamichael, Athens University Department of Clinical Therapeutics, Alexandra University Hospital Athens GreeceGeorgia Vamvakou, Athens University Department of Clinical Therapeutics, Alexandra University Hospital Athens GreeceIgnatios Ikonomidis, Athens University Department of Clinical Therapeuti...
Source: Cardiovascular Drugs and Therapy - August 12, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

Dronedarone: A Promısıng Alternatıve for the Management of Atrıal FıbrıllatıonEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Further clinical trials (including head to head comparison with other conventional anti-arrhythmics) are still required to determine the place of dronedarone in the management of AF. The present review focuses on basic and clinical aspects of dronedarone, a novel agent for the management of AF. Content Type Journal ArticleDOI 10.1007/s10557-009-6189-0Authors Kenan Yalta, Cumhuriyet University Cardiology Department Sivas 58100 TurkeyOkan Onur Turgut, Cumhuriyet University Cardiology Department Sivas 58100 TurkeyMehmet Birhan Yılmaz, Cumhuriyet University Cardiology Department Sivas 58100 Tu...
Source: Cardiovascular Drugs and Therapy - August 9, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

Fibrates may Cause an Abnormal Urinary Betaine Loss Which is Associated with Elevations in Plasma HomocysteineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Abnormal betaine excretion is common in patients treated with bezafibrate. Bezafibrate appears to exacerbate betaine loss, which will cause a rise in plasma homocysteine. Betaine supplementation could be considered in conjunction with fibrate therapy. Content Type Journal ArticleDOI 10.1007/s10557-009-6188-1Authors Michael Lever, Canterbury Health Laboratories Biochemistry Unit P.O. Box 151 Christchurch 8140 New ZealandPeter M. George, Canterbury Health Laboratories Biochemistry Unit P.O. Box 151 Christchurch 8140 New ZealandSandy Slow, Canterbury Health Laboratories Biochemistry Unit P.O. ...
Source: Cardiovascular Drugs and Therapy - August 3, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

Treatment of Hypertension in Metabolic Syndrome Subjects with Amlodipine and Olmesartan—Effects on Oxidized Non-Esterified Free Fatty Acids and Cytokine ProductionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Despite experimental data that demonstrates that angiotensin receptor antagonists reduce cellular oxidant stress and inflammation, olmesartan was not different than amlodipine in changing ox-NEFA and inflammatory markers in hypertensive subjects with the metabolic syndrome. Content Type Journal ArticleDOI 10.1007/s10557-009-6185-4Authors Robert S. Rosenson, Department of Medicine Divisions of Endocrinology, Diabetes and Metabolism, and Cardiovascular Medicine SUNY Downstate, 450 Clarkson Avenue, Box 1205 Brooklyn NY 11203 USA Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7...
Source: Cardiovascular Drugs and Therapy - July 30, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

Atorvastatin Improves Endothelial Function and Cardiac Performance in Patients with Dilated Cardiomyopathy: The Role of InflammationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Twelve weeks of treatment with atorvastatin significantly decreased serum sICAM-1, CRP and vWF levels, and improved the FMD, LVEF and 6MWT outcomes. Inhibition of inflammation, alleviating endothelium damage and endothelial dysfunction might comprise part of the underlying mechanisms leading to the improvement of LV function and exercise tolerance in patients with IDCM. Content Type Journal ArticleDOI 10.1007/s10557-009-6186-3Authors Miao Liu, Huazhong University of Science and Technology Department of paediatrics, Wuhan Union Hospital Wuhan 430022 ChinaFang Wang, Huazhong University of Sc...
Source: Cardiovascular Drugs and Therapy - July 27, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

Statins and Vitamin DEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory EditorialDOI 10.1007/s10557-009-6182-7Authors David S. Grimes, Royal Blackburn Hospital Blackburn BB2 3HH UK Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - July 18, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

Pharmacological Preconditioning in Type 2 Diabetic Rat Hearts: The Roles of Mitochondrial ATP-Sensitive Potassium Channels and the Phosphatidylinositol 3-Kinase-Akt PathwayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Olprinone but not isoflurane protects the heart against myocardial infarction in type 2 diabetic rats. The olprinone-induced cardioprotective effect is mediated by the PI3K-Akt pathway but not PKC or m-KATP channels. Content Type Journal ArticleDOI 10.1007/s10557-009-6184-5Authors Shuhei Matsumoto, Nagasaki University School of Medicine Department of Anesthesiology 1-7-1 Sakamoto Nagasaki 852-8501 JapanSungsam Cho, Nagasaki University School of Medicine Department of Anesthesiology 1-7-1 Sakamoto Nagasaki 852-8501 JapanShinya Tosaka, Nagasaki University School of Medicine Department of Anes...
Source: Cardiovascular Drugs and Therapy - July 14, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

Cardiovascular and Renal Surrogate Markers in the Clinical Management of HypertensionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions BNP, UACR, UAER, and LVMI, among others, have been increasingly established as valid surrogate markers with significant value for hypertension prognosis and therapy. The benefits of using surrogate markers to gauge the effectiveness of hypertension therapy in reducing renal and cardiac complications can be seen in improved morbidity and mortality. Content Type Journal ArticleDOI 10.1007/s10557-009-6177-4Authors Alan S. Maisel, Veterans Affairs San Diego Healthcare System Coronary Care Unit and Heart Failure Program 3350 La Jolla Village Drive, Cardiology Section, mc 9111A San Diego CA 9216...
Source: Cardiovascular Drugs and Therapy - July 6, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

Suppression of Collagen Production in Norepinephrine Stimulated Cardiac Fibroblasts Culture: Differential Effect of α and β-Adrenoreceptor AntagonismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions In conclusion, NE increased collagen gene and protein expressions in CF culture. This effect is likely mediated through α-receptor as they were normalized by pretreatment with carvedilol and doxazosin, but not β-blockers such as propranolol and metoprolol. Also, TGF-β1 doesn’t seem to play a role in carvedilol inhibition of NE induced fibrogenesis. Content Type Journal ArticleDOI 10.1007/s10557-009-6183-6Authors Ka-Bik Lai, Li Ka Shing Institute of Health and Science, Institute of Vascular Medicine, and Division of Cardiology, The Chinese University of Hong Kong Department of Medicine...
Source: Cardiovascular Drugs and Therapy - July 6, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

Hyponatremia in Heart Failure: The Role of Arginine Vasopressin and DiureticsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Vasopressin-receptor antagonists may prove useful in the treatment of HF; however, the exact role of these agents in the treatment of HF still requires further study. Content Type Journal ArticleDOI 10.1007/s10557-009-6180-9Authors Mitchell H. Rosner, University of Virginia Health System Division of Nephrology, Department of Medicine Box 800133 Charlottesville VA 22908 USA Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - June 25, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

Pharmacological Treatment of Patients with Chronic Critical Limb Ischemia: L-Propionyl-Carnitine Enhances the Short-Term Effects of PGE-1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Our study shows that LPC, whose effectiveness on claudication is already known, has favourable effects in patients with CLI, since it reinforces the effects produced by PGE-1. Content Type Journal ArticleDOI 10.1007/s10557-009-6178-3Authors Glauco Milio, University of Palermo Department of Internal Medicine Cardiovascular and Nephro-Urological Diseases Via M. Rutelli 9-90143 Palermo ItalyGiuseppina Novo, University of Palermo Department of Internal Medicine Cardiovascular and Nephro-Urological Diseases Via M. Rutelli 9-90143 Palermo ItalyCaterina Genova, University of Palermo Department of ...
Source: Cardiovascular Drugs and Therapy - June 23, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

Increased Levels of 25 Hydroxyvitamin D and 1,25-Dihydroxyvitamin D After Rosuvastatin Treatment: A Novel Pleiotropic Effect of Statins?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion This study has shown an effect of rosuvastatin on vitamin D metabolism, with an increase in both 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D. This may be an important pleiotropic effect whereby rosuvastatin reduces mortality in patients with coronary artery disease. Further studies are needed to clarify the relationship between statins and vitamin D metabolism. Content Type Journal ArticleDOI 10.1007/s10557-009-6181-8Authors Bunyamin Yavuz, Department of Cardiology Kecioren Teaching and Research Hospital Ankara TurkeyDerun Taner Ertugrul, Department of Internal Medicine Kecioren Teachin...
Source: Cardiovascular Drugs and Therapy - June 20, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

Myocardial Infarct Size-Limiting and Anti-Arrhythmic Effects of Mildronate Orotate in the Rat HeartEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The study provides experimental evidence that the combination of orotic acid and mildronate possesses additive pharmacological effects and that mildronate orotate might be considered as a powerful therapeutic agent facilitating recovery from ischemia-reperfusion injury. Content Type Journal ArticleDOI 10.1007/s10557-009-6179-2Authors Reinis Vilskersts, Latvian Institute of Organic Synthesis Aizkraukles Str. 21 Riga LV1006 LatviaEdgars Liepinsh, Latvian Institute of Organic Synthesis Aizkraukles Str. 21 Riga LV1006 LatviaJanis Kuka, Latvian Institute of Organic Synthesis Aizkraukles Str. 21...
Source: Cardiovascular Drugs and Therapy - June 18, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

The President’s Page: Target Response or Target DoseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleDOI 10.1007/s10557-009-6175-6Authors Jay N. Cohn, University of Minnesota Medical School ISCP Minneapolis MN 55455 USA Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - May 28, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

One Hour Reperfusion is Enough to Assess Function and Infarct Size With TTC Staining in Langendorff Rat ModelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion In conclusion, we showed that prolonged reperfusion beyond 60 min was not useful for function assessment and did not change infarct size measurement, on Langendorff rat model of ischemia-reperfusion. Content Type Journal ArticleCategory SHORT COMMUNICATIONDOI 10.1007/s10557-009-6176-5Authors R. Ferrera, Université de Lyon INSERM U886 Université Lyon 1 Lyon F-69008 FranceS. Benhabbouche, Université de Lyon INSERM U886 Université Lyon 1 Lyon F-69008 FranceJ. C. Bopassa, Université de Lyon INSERM U886 Université Lyon 1 Lyon F-69008 FranceB. Li, Université de Lyon INSERM U886 Univers...
Source: Cardiovascular Drugs and Therapy - May 24, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

Response to the Letter of Hester Den Ruijter and Ruben Coronel Regarding the Article “The Role of n-3 PUFAs in Preventing the Arrhythmic Risk in Patients with Idiopathic Dilated Cardiomyopathy”Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleDOI 10.1007/s10557-009-6174-7Authors Savina Nodari, University of Brescia Section of Cardiovascular Diseases, Department of Experimental and Applied Medicine c/o Spedali Civili, P.zza Spedali Civili 25100 Brescia ItalyMarco Metra, University of Brescia Section of Cardiovascular Diseases, Department of Experimental and Applied Medicine c/o Spedali Civili, P.zza Spedali Civili 25100 Brescia ItalyGiuseppe Milesi, University of Brescia Section of Cardiovascular Diseases, Department of Experimental and Applied Medicine c/o Spedali Civili, P.zza Spedali Civili 25100 Brescia ItalyAlessandra Manerba...
Source: Cardiovascular Drugs and Therapy - May 14, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

Pharmacological Approaches to Modifying HDL: More Basic Science to Understand HDL Metabolism is NecessaryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory EditorialDOI 10.1007/s10557-009-6171-xAuthors Michael H. Davidson, The University of Chicago Pritzker School of Medicine Preventive Cardiology Chicago IL USA Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - May 12, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

Obituary of Philip Poole-Wilson, Member of the Board of Directors of the International Society of Cardiovascular PharmacotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory ObituaryDOI 10.1007/s10557-009-6173-8Authors Inder Anand, VA Medical Center 111C University of Minnesota Medical School, Heart Failure Program Minneapolis MN 55417 USA Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - May 7, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

The Response to Fish Oil in Patients with Heart Disease Depends on the Predominant Arrhythmia MechanismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Letter to the EditorDOI 10.1007/s10557-009-6172-9Authors Hester M. Den Ruijter, University of Amsterdam Experimental Cardiology Group, Heart Failure Research Center Amsterdam The NetherlandsRuben Coronel, University of Amsterdam Experimental Cardiology Group, Heart Failure Research Center Amsterdam The Netherlands Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - April 25, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

Nesiritide, Heart Failure, and Renal Dysfunction: Irrational Exuberance or Throwing the Baby out with the BathwaterEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory EditorialDOI 10.1007/s10557-009-6169-4Authors Ronald M. Witteles, Stanford University School of Medicine Division of Cardiovascular Medicine 300 Pasteur Dr., Falk Cardiovascular Research Center #273 Stanford CA 94305-5406 USA Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - April 8, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

Dofetilide as Activator of Na/Ca Exchange: New Perspectives on an ‘Old’ DrugEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory EditorialDOI 10.1007/s10557-009-6170-yAuthors Gudrun Antoons, University of Leuven Division Experimental Cardiology, Department of Cardiovascular Medicine Leuven BelgiumKarin R. Sipido, University of Leuven Division Experimental Cardiology, Department of Cardiovascular Medicine Leuven Belgium Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - April 2, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

ISCP President’s PageEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleDOI 10.1007/s10557-009-6166-7Authors Jay N. Cohn, ISCP University of Minnesota Medical School Minneapolis MN 55455 USA Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - March 3, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

Remote Postconditioning is More Potent than Classic Postconditioning in Reducing the Infarct Size in Anesthetized RabbitsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Remote postconditioning consisted of 1 min isc/1 min rep protects the ischemic rabbit heart in vivo, independently of the site of the remote artery. This intervention seems to confer a stronger protection than the classic postconditioning. Content Type Journal ArticleDOI 10.1007/s10557-009-6168-5Authors G. Gritsopoulos, University of Athens Medical School, Attikon University Hospital, Athens Second Department of Cardiology 182 Kallergi St 18544 Piraeus GreeceE. K. Iliodromitis, University of Athens Medical School, Attikon University Hospital, Athens Second Department of Cardiology ...
Source: Cardiovascular Drugs and Therapy - March 3, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

Impact of Nesiritide on Renal Function and Mortality in Patients Suffering from Heart FailureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Extreme caution is required when using nesiritide in patients with both heart failure and concurrent morbidities such as renal dysfunction. Content Type Journal ArticleDOI 10.1007/s10557-009-6167-6Authors Ioannis D. Dontas, University of Athens, Medical School Department of Experimental Surgery and Surgical Research “N.S.Christeas” 15B Agiou Thoma Street 11527 Athens GreeceTheodoros Xanthos, University of Athens, Medical School Department of Experimental Surgery and Surgical Research “N.S.Christeas” 15B Agiou Thoma Street 11527 Athens GreeceIsmene Dontas, University of Athens, Medica...
Source: Cardiovascular Drugs and Therapy - February 28, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

NO-1886 Up-regulates Niemann–Pick C1 Protein (NPC1) Expression Through Liver X Receptor α Signaling Pathway in THP-1 Macrophage-Derived Foam CellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion These results provide evidence that NO-1886 up-regulates expression of NPC1 through LXR α pathway in THP-1 macrophage- derived foam cells. Content Type Journal ArticleDOI 10.1007/s10557-009-6165-8Authors Xin Ma, University of South China Institute of Cardiovascular Research, Key Laboratory for Atherosclerology of Hunan Province, Life Science Research Center Hengyang Hunan 421001 ChinaYan-Wei Hu, University of South China Institute of Cardiovascular Research, Key Laboratory for Atherosclerology of Hunan Province, Life Science Research Center Hengyang Hunan 421001 ChinaZhong-Cheng Mo, Universi...
Source: Cardiovascular Drugs and Therapy - February 20, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

Randomised, Double-Blind, Placebo-Controlled Trial of Ivabradine in Patients with Acute Coronary Syndrome: Effects of the If Current Inhibitor Ivabradine on Reduction of Inflammation Markers in Patients with Acute Coronary Syndrome—RIVIERA Trial Study Design and RationaleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion We hypothesize that ivabradine therapy, when started immediately after hospital admission for ACS, will result in the reduction of hs-CRP levels and the improvement of cardiovascular outcome. Content Type Journal ArticleDOI 10.1007/s10557-009-6164-9Authors Alberto Dominguez-Rodriguez, University Hospital of Canarias Department of Cardiology Tenerife SpainSima Samimi Fard, University Hospital of Canarias Department of Cardiology Tenerife SpainPedro Abreu-Gonzalez, University of La Laguna Department of Physiology Tenerife SpainFrancisco Bosa-Ojeda, University Hospital of Canarias Department of...
Source: Cardiovascular Drugs and Therapy - February 20, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

Randomised, Double-Blind, Placebo-Controlled Trial of Ivabradine in Patients with Acute Coronary Syndrome: Effects of the I f Current Inhibitor Ivabradine on Reduction of Inflammation Markers in Patients with Acute Coronary Syndrome—RIVIERA Trial Study Design and RationaleEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion We hypothesize that ivabradine therapy, when started immediately after hospital admission for ACS, will result in the reduction of hs-CRP levels and the improvement of cardiovascular outcome. Content Type Journal ArticleDOI 10.1007/s10557-009-6164-9Authors Alberto Dominguez-Rodriguez, University Hospital of Canarias Department of Cardiology Tenerife SpainSima Samimi Fard, University Hospital of Canarias Department of Cardiology Tenerife SpainPedro Abreu-Gonzalez, University of La Laguna Department of Physiology Tenerife SpainFrancisco Bosa-Ojeda, University Hospital of Canarias Department of...
Source: Cardiovascular Drugs and Therapy - February 20, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

Dofetilide Enhances the Contractility of Rat Ventricular Myocytes via Augmentation of Na+–Ca2+ ExchangeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions We conclude that DOF enhanced contractility of rat ventricular myocytes. The enhancement of NCE may be involved in the positive inotropic action of DOF. Content Type Journal ArticleDOI 10.1007/s10557-009-6163-xAuthors Xuan-Ping Zhang, Shanxi Medical University Department of Pharmacology No.56 Xinjian Nanlu Taiyuan Shanxi 030001 People’s Republic of ChinaBo-Wei Wu, Shanxi Medical University Department of Physiology Taiyuan Shanxi 030001 People’s Republic of ChinaCai-Hong Yang, Shanxi Medical University Department of Pharmacology No.56 Xinjian Nanlu Taiyuan Shanxi 030001 People’s Republ...
Source: Cardiovascular Drugs and Therapy - February 17, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

Tomato Extract for Hypertension?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory EditorialDOI 10.1007/s10557-008-6161-4Authors Peter W. de Leeuw, University Hospital Maastricht Department of Medicine P.O. Box 5800 6202 AZ Maastricht The NetherlandsAalt Bast, University of Maastricht Department of Pharmacology, Cardiovascular Research Institute Maastricht (CARIM) P.O. Box 616 6200 MD Maastricht The Netherlands Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - February 14, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

AnnouncementsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleDOI 10.1007/BF03029737 Journal Cardiovascular Drugs and TherapyOnline ISSN 1573-7241Print ISSN 0920-3206 Journal Volume Volume 5 Journal Issue Volume 5, Number 3 / June, 1991 (Source: Cardiovascular Drugs and Therapy)
Source: Cardiovascular Drugs and Therapy - January 31, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

Double-Blind, randomized comparative study of the antihypertensive effect of nicardipine slow-release and nifedipine slow-release in hypertensive patients with coronary heart diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary The main aim of this study was to investigate whether a new slow-release formulation of nicardipine can control hypertension and whether its antihypertensive effect is manifest throughout the dose intervals. In a randomized, double-blind placebo-controlled study, the antihypertensive effect of two calcium antagonists (Type II) was investigated in two independent groups of hypertensive patients with coronary artery disease. One group of patients received 40 mg nicardipine slow-release b.i.d. and the other 20 mg nifedipine slow-release b.i.d. The effect of the active drugs on blood pressure (BP), heart...
Source: Cardiovascular Drugs and Therapy - January 31, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

Subcellular localization of prostaglandin-E2 in rat heart tissueEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary It has been reported that isolated rat heart myocytes and cardiac mesenchymal cells convert arachidonic acid mainly into three types of prostaglandins (PGs): PGE2, PGF2α, and PGI2 [1]. In addition, we have demonstrated that fresh atrial slices of patients with heart-valve disease contain appreciable quantities of PGE2 and PGF2α [2]. However, there have been no reports on the subcellular localization of the prostaglandin system in heart muscle tissue. The present study was performed to define the distribution of PGE2 in mitochondrial, microsomal, and cytosolic fractions, isolated by differential cent...
Source: Cardiovascular Drugs and Therapy - January 31, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals

Hemodynamic effects of benazepril, an angiotensin-converting enzyme inhibitor, as studied in conscious normotensive dogsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary Hemodynamic effects and inhibitory effects on the pressor response to exogenous angiotensin I of benazepril (CGS 14824A), a new angiotensin-converting enzyme (ACE) inhibitor, were examined in conscious chronically instrumented normotensive dogs in comparison with those of captorpil. Oral administration of benazepril (1–10 mg/kg) and captopril (3 and 10 mg/kg) reduced the blood pressure and inhibited the pressor response to angiotensin I dose-dependently. The blood-pressure-lowering effect of benazepril was as potent as that of captopril. The onset of effects of benazepril was slower and the duratio...
Source: Cardiovascular Drugs and Therapy - January 31, 2009 Category: Cardiology Tags: Cardiovascular Drugs and Therapy Source Type: journals