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Matrix metalloproteinase-2 and -9 exacerbate arterial stiffening and angiogenesis in diabetes and chronic kidney diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Using a matched case–control design, we report up-regulation of MMP-2 and -9 in diabetic CKD arteries and correlate those with stiffening, impaired angiogenesis, and endothelial dysfunction. These findings may help to explain the high susceptibility of CVD in diabetic and non-diabetic CKD patients. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 16, 2009 Category: Cardiology Authors: Chung, A. W.Y., Yang, H.H. C., Sigrist, M. K., Brin, G., Chum, E., Gourlay, W. A., Levin, A. Tags: ORIGINAL ARTICLES Source Type: journals

The anti-inflammatory agent bindarit inhibits neointima formation in both rats and hyperlipidaemic miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion This study demonstrates that bindarit is effective in reducing neointima formation in both non-hyperlipidaemic and hyperlipidaemic animal models of vascular injury by a direct effect on VSMC proliferation and migration and by reducing neointimal macrophage content. All of these data were associated with the inhibition of MCP-1 production. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 16, 2009 Category: Cardiology Authors: Grassia, G., Maddaluno, M., Guglielmotti, A., Mangano, G., Biondi, G., Maffia, P., Ialenti, A. Tags: ORIGINAL ARTICLES Source Type: journals

C-reactive protein impairs the endothelial glycocalyx resulting in endothelial dysfunctionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Collectively, these data suggest that C-reactive protein impairs glycocalyx function, resulting in endothelial dysfunction. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 16, 2009 Category: Cardiology Authors: Devaraj, S., Yun, J.-M., Adamson, G., Galvez, J., Jialal, I. Tags: ORIGINAL ARTICLES Source Type: journals

Attenuated store-operated Ca2+ entry underpins the dual inhibition of nitric oxide and EDHF-type relaxations by iodinated contrast mediaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The data support the hypothesis that IRCM induce generalized endothelial dysfunction by inhibiting Ca2+ influx via SOCs rather than their assembly. The presence of organically bound iodine, rather than osmolar effects, may underpin this previously unrecognized phenomenon. In contrast, direct effects of IRCM on smooth muscle function may correlate with osmolarity rather than iodine concentration. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 16, 2009 Category: Cardiology Authors: Fernandez-Rodriguez, S., Edwards, D. H., Newton, B., Griffith, T. M. Tags: ORIGINAL ARTICLES Source Type: journals

A new transmyocardial degradable stent combined with growth factor, heparin, and stem cells in acute myocardial infarctionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion We have demonstrated in a pig model that an intramyocardial stent implanted with slow release of bFGF, heparin, and BMSC transplantation may significantly increase LV function, cardiac blood flow, and vascular density. Therefore, the present study may provide a new method for the surgical treatment of myocardial infarction. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 16, 2009 Category: Cardiology Authors: Wang, Y., Liu, X.-C., Zhang, G.-W., Zhao, J., Zhang, J.-M., Shi, R.-F., Huang, Y.-Z., Zhao, C.-H., Liu, T.-J., Song, C.-X., Lu, F., Yang, Q., He, G.-W. Tags: ORIGINAL ARTICLES Source Type: journals

Reducing ischaemia/reperfusion injury through {delta}-opioid-regulated intrinsic cardiac adrenergic cells: adrenopeptidergic co-signallingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion ICA cells constitute a -opioid-regulated adrenopeptidergic paracrine system conferring robust cardioprotection through β2-AR/CGRP-R co-signalling, resulting in the activation of an anti-apoptotic pathway during ischaemia/reperfusion. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 16, 2009 Category: Cardiology Authors: Huang, M.-H., Nguyen, V., Wu, Y., Rastogi, S., Lui, C. Y., Birnbaum, Y., Wang, H.-Q., Ware, D. L., Chauhan, M., Garg, N., Poh, K.-K., Ye, L., Omar, A. R., Tan, H.-C., Uretsky, B. F., Fujise, K. Tags: ORIGINAL ARTICLES Source Type: journals

The TIR/BB-loop mimetic AS-1 protects the myocardium from ischaemia/reperfusion injuryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The results demonstrated an important role for the IL-1R-mediated MyD88-dependent signalling pathway in myocardial I/R injury. The data suggest that modulation of the IL-1R/MyD88 interaction could be a strategy for reducing myocardial ischaemic injury. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 16, 2009 Category: Cardiology Authors: Cao, Z., Hu, Y., Wu, W., Ha, T., Kelley, J., Deng, C., Chen, Q., Li, C., Li, J., Li, Y. Tags: ORIGINAL ARTICLES Source Type: journals

MicroRNA-1 downregulation by propranolol in a rat model of myocardial infarction: a new mechanism for ischaemic cardioprotectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion We conclude that the β-adrenergic pathway can stimulate expression of arrhythmogenic miR-1, contributing to ischaemic arrhythmogenesis, and β-blockers produce their beneficial effects partially by down-regulating miR-1, which might be a novel strategy for ischaemic cardioprotection. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 16, 2009 Category: Cardiology Authors: Lu, Y., Zhang, Y., Shan, H., Pan, Z., Li, X., Li, B., Xu, C., Zhang, B., Zhang, F., Dong, D., Song, W., Qiao, G., Yang, B. Tags: ORIGINAL ARTICLES Source Type: journals

Amelioration of myocarditis by HVEM-overexpressing dendritic cells through induction of IL-10-producing cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Myosin-DC-AdHVEM cell gene therapy appears to be a safe and effective way of inhibiting the development of EAM. The signal induced by HVEM seems to play different roles in different cells. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 16, 2009 Category: Cardiology Authors: Cai, G., Wang, H., Qin, Q., Zhang, J., Zhu, Z., Liu, M., Shen, Q. Tags: ORIGINAL ARTICLES Source Type: journals

NF-{kappa}B activation is required for adaptive cardiac hypertrophyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion NF-B inhibition attenuates cardiac hypertrophy in a gender-specific manner but does not alter the course of stress-induced LV remodelling, indicating NF-B to be required for adaptive cardiac hypertrophy. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 16, 2009 Category: Cardiology Authors: Zelarayan, L., Renger, A., Noack, C., Zafiriou, M.-P., Gehrke, C., van der Nagel, R., Dietz, R., de Windt, L., Bergmann, M. W. Tags: ORIGINAL ARTICLES Source Type: journals

The G protein coupled receptor kinase 2 plays an essential role in beta-adrenergic receptor-induced insulin resistanceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Our results suggest that GRK2 mediates adrenergic IRES and that inhibition of GRK2 activity leads to increased Ins sensitivity both in cells and in animal model of IRES. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 16, 2009 Category: Cardiology Authors: Cipolletta, E., Campanile, A., Santulli, G., Sanzari, E., Leosco, D., Campiglia, P., Trimarco, B., Iaccarino, G. Tags: ORIGINAL ARTICLES Source Type: journals

Transgenic simulation of human heart failure-like L-type Ca2+-channels: implications for fibrosis and heart rate in miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Cardiac overexpression of a Ca2+-channel β2a-subunit alone is sufficient to induce Ca2+-channel properties characteristic of chronic human heart failure. β2a-overexpression by itself did not induce cardiac hypertrophy or contractile dysfunction, but aggravated the development of arrhythmia and fibrosis in Cav1.2-transgenic mice. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 16, 2009 Category: Cardiology Authors: Beetz, N., Hein, L., Meszaros, J., Gilsbach, R., Barreto, F., Meissner, M., Hoppe, U. C., Schwartz, A., Herzig, S., Matthes, J. Tags: ORIGINAL ARTICLES Source Type: journals

Redox modification of ryanodine receptors underlies calcium alternans in a canine model of sudden cardiac deathEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Redox modulation of RyRs promotes generation of Ca2+ alternans by enhancing the steepness of the Ca2+ release–load relationship and thereby providing a substrate for post-MI arrhythmias. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 16, 2009 Category: Cardiology Authors: Belevych, A. E., Terentyev, D., Viatchenko-Karpinski, S., Terentyeva, R., Sridhar, A., Nishijima, Y., Wilson, L. D., Cardounel, A. J., Laurita, K. R., Carnes, C. A., Billman, G. E., Gyorke, S. Tags: ORIGINAL ARTICLES Source Type: journals

CB1 and CB2 cannabinoid receptors differentially regulate the production of reactive oxygen species by macrophagesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion CB1 promotes pro-inflammatory responses of macrophages through ROS production, which is negatively regulated by CB2 through Rap1 activation. Blocking CB1 together with selective activation of CB2 may suppress pro-inflammatory responses of macrophages. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 16, 2009 Category: Cardiology Authors: Han, K. H., Lim, S., Ryu, J., Lee, C.-W., Kim, Y., Kang, J.-H., Kang, S.-S., Ahn, Y. K., Park, C.-S., Kim, J. J. Tags: ORIGINAL ARTICLES Source Type: journals

Maintenance of adrenergic vascular tone by MMP transactivation of the EGFR requires PI3K and mitochondrial ATP synthesisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion These data suggest that the maintenance of adrenergic vascular tone by the MMP–EGFR pathway requires PI3K activation and ATP synthesis. Further, our data support the view that elevated levels of GPCR agonists exaggerate the MMP transactivation of EGFR response and contribute to enhanced vascular tone and development of cardiovascular disease such as hypertension. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 16, 2009 Category: Cardiology Authors: Nagareddy, P. R., Chow, F. L., Hao, L., Wang, X., Nishimura, T., MacLeod, K. M., McNeill, J. H., Fernandez-Patron, C. Tags: ORIGINAL ARTICLES Source Type: journals

Cx43 CT domain influences infarct size and susceptibility to ventricular tachyarrhythmias in acute myocardial infarctionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Loss of the regulatory domain of Cx43 leads to an increase in infarct size and increased susceptibility to arrhythmias following acute coronary occlusion. (Source: Cardiovascular Research)
Source: Cardiovascular Research - November 16, 2009 Category: Cardiology Authors: Maass, K., Chase, S. E., Lin, X., Delmar, M. Tags: ORIGINAL ARTICLES Source Type: journals

Interleukin 8 and cardiovascular diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Since the establishment of the inflammatory basis of atherosclerosis, several pro- or anti-inflammatory agents have been examined as potential mediators of the biochemical pathways of lesion formation. Interleukin (IL)-8 was first characterized in 1987. Since then, knowledge regarding its role in leucocyte trafficking and activation has advanced rapidly, especially in the field of cardiovascular disease. In the scientific literature, there is sufficient evidence to support beyond any doubt the involvement of IL-8 in the establishment and preservation of the inflammatory micro-environment of the insulted vascular wall. Howe...
Source: Cardiovascular Research - November 16, 2009 Category: Cardiology Authors: Apostolakis, S., Vogiatzi, K., Amanatidou, V., Spandidos, D. A. Tags: REVIEWS Source Type: journals

Targeting calcium transport in ischaemic heart diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ischaemic heart disease (IHD) is the leading cause of morbidity and mortality worldwide. While timely reperfusion of acutely ischaemic myocardium is essential for myocardial salvage, it leads to a unique type of injury known as ‘myocardial ischaemia/reperfusion (I/R) injury’. Growing evidence suggests that a defect in myocardial Ca2+ transport system with cytosolic Ca2+ overload is a major contributor to myocardial I/R injury. Progress in molecular genetics and medicine in past years has clearly demonstrated that modulation of Ca2+ handling pathways in IHD could be cardioprotective. The potential benefits of th...
Source: Cardiovascular Research - November 16, 2009 Category: Cardiology Authors: Talukder, M.A. H., Zweier, J. L., Periasamy, M. Tags: REVIEWS Source Type: journals

'Leaky' ryanodine receptors and sudden cardiac deathEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Cardiovascular Research)
Source: Cardiovascular Research - November 16, 2009 Category: Cardiology Authors: Brown, D. A., Cascio, W. E. Tags: EDITORIALS Source Type: journals

Endocannabinoid signalling as an anti-inflammatory therapeutic target in atherosclerosis: does it work?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Cardiovascular Research)
Source: Cardiovascular Research - November 16, 2009 Category: Cardiology Authors: Immenschuh, S. Tags: EDITORIALS Source Type: journals

Vasoconstriction: tightening the noose through MMPsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Cardiovascular Research)
Source: Cardiovascular Research - November 16, 2009 Category: Cardiology Authors: Isenberg, J. S., Shiva, S. Tags: EDITORIALS Source Type: journals

The tail of Cx43: its crucial protective role in acute myocardial infarctionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Cardiovascular Research)
Source: Cardiovascular Research - November 16, 2009 Category: Cardiology Authors: Wang, Y., Cheng, Y. Tags: EDITORIALS Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Cardiovascular Research)
Source: Cardiovascular Research - November 16, 2009 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: journals

Contents PageEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Cardiovascular Research)
Source: Cardiovascular Research - November 16, 2009 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: journals

Announcement: Spotlight Issue on Microvascular PermeabilityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Cardiovascular Research)
Source: Cardiovascular Research - November 16, 2009 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: journals

Aims and ScopeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Cardiovascular Research)
Source: Cardiovascular Research - November 16, 2009 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: journals

Corrigendum to: Chlamydia heat shock protein 60 decreases expression of endothelial nitric oxide synthase in human and porcine coronary artery endothelial cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Cardiovascular Research)
Source: Cardiovascular Research - October 13, 2009 Category: Cardiology Authors: Chen, C., Chai, H., Wang, X., Lin, P. H., Yao, Q. Tags: CORRIGENDUM Source Type: journals

Arterial gene transfer of the TGF-{beta} signalling protein Smad3 induces adaptive remodelling following angioplasty: a role for CTGFEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Medial gene transfer of Smad3 promotes adaptive remodelling by indirectly influencing the behaviour of adventitial fibroblasts. This arterial cell–cell communication is likely to be mediated by Smad3-dependent production of CTGF. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 13, 2009 Category: Cardiology Authors: Kundi, R., Hollenbeck, S. T., Yamanouchi, D., Herman, B. C., Edlin, R., Ryer, E. J., Wang, C., Tsai, S., Liu, B., Kent, K. C. Tags: ORIGINAL ARTICLES Source Type: journals

Bone marrow-derived cells do not repair endothelium in a mouse model of chronic endothelial cell dysfunctionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion We found no evidence for BM-derived EPC renewal of endothelium in this eNOS-deficient mouse model of a chronic vascular disease or in wild-type mice during postnatal growth. Hence, renewal of chronic dysfunctional endothelium and endothelial homeostasis may be dependent on resident vascular progenitor cells. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 13, 2009 Category: Cardiology Authors: Perry, T. E., Song, M., Despres, D. J., Kim, S. M., San, H., Yu, Z.-X., Raghavachari, N., Schnermann, J., Cannon, R. O., Orlic, D. Tags: ORIGINAL ARTICLES Source Type: journals

Serotonin enhances platelet procoagulant properties and their activation induced during platelet tissue factor uptakeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Serotonin enhances the interaction of platelets with TF-MVs, increases platelet activation, and potentiates their overall procoagulant activity. The present results could have significant implications in thrombus formation and in the thrombogenic profile of pathological situations with increased cardiovascular risk. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 13, 2009 Category: Cardiology Authors: Lopez-Vilchez, I., Diaz-Ricart, M., White, J. G., Escolar, G., Galan, A. M. Tags: ORIGINAL ARTICLES Source Type: journals

Ovariectomy increases the formation of prostanoids and modulates their role in acetylcholine-induced relaxation and nitric oxide release in the rat aortaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Despite the prevalence of vasoconstrictor prostanoids derived from COX-2 in aortas from ovariectomized rats, the ACh-induced relaxation is maintained, probably as consequence of the positive regulation that prostanoids exert on eNOS activity. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 13, 2009 Category: Cardiology Authors: Martorell, A., Sagredo, A., Aras-Lopez, R., Balfagon, G., Ferrer, M. Tags: ORIGINAL ARTICLES Source Type: journals

Endothelium-specific overexpression of human IC53 downregulates endothelial nitric oxide synthase activity and elevates systolic blood pressure in miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Our results indicate that IC53 participates in the regulation of vascular homeostasis. Endothelium-specific overexpression of IC53 is associated with elevated SBP, which may be in part attributed to the downregulation of eNOS signalling. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 13, 2009 Category: Cardiology Authors: Zhuo, M.-L., Huang, Y., Chen, J.-Z., Sun, L.-H., Yang, R.-F., Chen, H.-Z., Lv, X., Li, H.-L., Wei, Y.-S., Liu, G., Zhang, R., Ma, T.-M., Cai, H., Hui, R.-T., Liu, D.-P., Liang, C.-C. Tags: ORIGINAL ARTICLES Source Type: journals

Sympathoinhibitory mechanism of moxonidine: role of the inducible nitric oxide synthase in the rostral ventrolateral medullaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The present data suggest that an NO mechanism generated by iNOS in the RVLM plays an important role in mediating the sympathetic inhibition of the centrally acting drug moxonidine. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 13, 2009 Category: Cardiology Authors: Peng, J., Wang, Y.-K., Wang, L.-G., Yuan, W.-J., Su, D.-F., Ni, X., Deng, X.-M., Wang, W.-Z. Tags: ORIGINAL ARTICLES Source Type: journals

Mouse strain determines the outcome of wound healing after myocardial infarctionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The outcome of infarct healing in mice strongly depends on genetic background. On the basis of our results, we suggest that for studies on infarct rupture, the 129S6 mouse is the background of choice, whereas BalbC and Swiss mice are the preferred models to study infarct thinning post-MI. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 13, 2009 Category: Cardiology Authors: van den Borne, S. W.M., van de Schans, V. A.M., Strzelecka, A. E., Vervoort-Peters, H. T.M., Lijnen, P. M., Cleutjens, J. P.M., Smits, J. F.M., Daemen, M. J.A.P., Janssen, B. J.A., Blankesteijn, W. M. Tags: ORIGINAL ARTICLES Source Type: journals

Forward programming of pluripotent stem cells towards distinct cardiovascular cell typesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Our findings show proof of principle for cardiovascular subtype-specific programming of pluripotent stem cells and confirm the molecular hierarchy for cardiovascular specification initiated via MesP1 with differentiation factors such as Nkx2.5 further downstream. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 13, 2009 Category: Cardiology Authors: David, R., Stieber, J., Fischer, E., Brunner, S., Brenner, C., Pfeiler, S., Schwarz, F., Franz, W.-M. Tags: ORIGINAL ARTICLES Source Type: journals

Dissociation of FKBP12.6 from ryanodine receptor type 2 is regulated by cyclic ADP-ribose but not {beta}-adrenergic stimulation in mouse cardiomyocytesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Our data demonstrate that dissociation of FKBP12.6 from the RYR2 complex does not play a significant role in β-adrenergic-stimulated Ca2+ release in heart cells, whereas this mechanism does underlie the action of cADPR. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 13, 2009 Category: Cardiology Authors: Zhang, X., Tallini, Y. N., Chen, Z., Gan, L., Wei, B., Doran, R., Miao, L., Xin, H.-B., Kotlikoff, M. I., Ji, G. Tags: ORIGINAL ARTICLES Source Type: journals

Autonomic mechanism for initiation of rapid firing from atria and pulmonary veins: evidence by ablation of ganglionated plexiEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion HFS applied to local atrial and PV sites initiated rapid firing via activation of the interactive autonomic network in the heart. GP in either left side or right side contributes to the rapid firings and AF originating from ipsolateral and contralateral PVs and atrium. Autonomic denervation suppresses or eliminates those rapid firings. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 13, 2009 Category: Cardiology Authors: Lu, Z., Scherlag, B. J., Lin, J., Yu, L., Guo, J.-H., Niu, G., Jackman, W. M., Lazzara, R., Jiang, H., Po, S. S. Tags: ORIGINAL ARTICLES Source Type: journals

Reverse rate dependency is an intrinsic property of canine cardiac preparationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion RRD of APD modulation is shared, although with differences in magnitude, by interventions of very different nature. RRD can be interpreted as a consequence of the relationship between Im and APD and, as such, is expected in all species having positive APD–CL relationship. This implies that the development of agents prolonging APD with direct rate dependency, or even completely devoid of RRD, may be difficult to achieve. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 13, 2009 Category: Cardiology Authors: Banyasz, T., Horvath, B., Virag, L., Barandi, L., Szentandrassy, N., Harmati, G., Magyar, J., Marangoni, S., Zaza, A., Varro, A., Nanasi, P. P. Tags: ORIGINAL ARTICLES Source Type: journals

Chronic heart failure and the substrate for atrial fibrillationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Chronic HF causes alterations in ion channel expression and ion currents, resulting in attenuation of the APD and atrial contractility and a substrate for persistent AF. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 13, 2009 Category: Cardiology Authors: Sridhar, A., Nishijima, Y., Terentyev, D., Khan, M., Terentyeva, R., Hamlin, R. L., Nakayama, T., Gyorke, S., Cardounel, A. J., Carnes, C. A. Tags: ORIGINAL ARTICLES Source Type: journals

Ascorbic acid and tetrahydrobiopterin potentiate the EDHF phenomenon by generating hydrogen peroxideEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Pro-oxidant effects of AA and BH4 can enhance the EDHF phenomenon by generating H2O2, which has previously been shown to amplify electrotonic hyperpolarization-mediated relaxation by facilitating Ca2+ release from endothelial stores. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 13, 2009 Category: Cardiology Authors: Garry, A., Edwards, D. H., Fallis, I. F., Jenkins, R. L., Griffith, T. M. Tags: ORIGINAL ARTICLES Source Type: journals

Atrial natriuretic peptide suppresses endothelin gene expression and proliferation in cardiac fibroblasts through a GATA4-dependent mechanismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Collectively, these findings suggest that locally produced ET-1 serves as an autocrine stimulator of fibroblast proliferation, that ANP produced in neighbouring myocytes serves as a paracrine inhibitor of this proliferation, and that the latter effect operates through a reduction in GATA4 phosphorylation and coincident reduction in GATA4-dependent transcriptional activity. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 13, 2009 Category: Cardiology Authors: Glenn, D. J., Rahmutula, D., Nishimoto, M., Liang, F., Gardner, D. G. Tags: ORIGINAL ARTICLES Source Type: journals

Ischaemic postconditioning protects against reperfusion injury via the SAFE pathwayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The protective effect of the SAFE pathway is shown in IPostC, with the activation of TNF, its receptor type 2, and STAT-3. This signalling cascade is activated independently of the well-known Reperfusion Injury Salvage Kinases (RISK) pathway, which involves the kinases Akt and Erk1/2. (Source: Cardiovascular Research)
Source: Cardiovascular Research - October 13, 2009 Category: Cardiology Authors: Lacerda, L., Somers, S., Opie, L. H., Lecour, S. Tags: ORIGINAL ARTICLES Source Type: journals

Molecular imaging using contrast-enhanced ultrasound: evaluation of angiogenesis and cell therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The field of regenerative medicine and its applications for cardiovascular diseases continues to grow rapidly, fuelled by the increasing numbers of symptomatic patients who are not candidates for conventional revascularization procedures and remain refractory to maximal medical therapy. Therapeutic angiogenesis, initially in the form of the administration of growth factor protein or gene therapy and, more recently, in the form of adult progenitor cell therapy, has emerged as a promising new method of treatment for patients with ischaemic heart disease and peripheral arterial disease. There is a growing interest in non-inva...
Source: Cardiovascular Research - October 13, 2009 Category: Cardiology Authors: Leong-Poi, H. Tags: REVIEWS Source Type: journals

Contrast ultrasound molecular imaging of inflammation in cardiovascular diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The cellular immune response plays an important role in almost every major form of cardiovascular disease. The ability to image the key aspects of the immune response in the clinical setting could be used to improve diagnostic information, to provide important prognostic or risk information, and to customize therapy according to disease phenotype. Accordingly, targeted imaging probes for assessing inflammation have been developed for essentially all forms of medical imaging. Molecular imaging of inflammation with contrast ultrasound relies on the detection of targeted microbubble or other gas-filled particle contrast agent...
Source: Cardiovascular Research - October 13, 2009 Category: Cardiology Authors: Lindner, J. R. Tags: REVIEWS Source Type: journals

Duration of heart failure and the risk of atrial fibrillation: different mechanisms at different times?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Cardiovascular Research)
Source: Cardiovascular Research - October 13, 2009 Category: Cardiology Authors: Rankin, A. C., Workman, A. J. Tags: EDITORIALS Source Type: journals

Ascorbic acid and tetrahydrobiopterin: looking beyond nitric oxide bioavailabilityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Cardiovascular Research)
Source: Cardiovascular Research - October 13, 2009 Category: Cardiology Authors: Muller-Delp, J. M. Tags: EDITORIALS Source Type: journals

GATA4, a new regulator of cardiac fibroblasts, is sensitive to natriuretic peptidesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Cardiovascular Research)
Source: Cardiovascular Research - October 13, 2009 Category: Cardiology Authors: Jankowski, M. Tags: EDITORIALS Source Type: journals

No RISK, no ... cardioprotection? A critical perspectiveEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Cardiovascular Research)
Source: Cardiovascular Research - October 13, 2009 Category: Cardiology Authors: Heusch, G. Tags: EDITORIALS Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Cardiovascular Research)
Source: Cardiovascular Research - October 13, 2009 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: journals

Contents PageEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Cardiovascular Research)
Source: Cardiovascular Research - October 13, 2009 Category: Cardiology Tags: FRONT-MATTER/BACK-MATTER Source Type: journals