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Effects of reducing beta-lactam antibiotic pressure on intestinal colonization of antibiotic-resistant gram-negative bacteriaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion A 35–39% reduction of β-lactam exposure was not associated with reduced acquisition of CRE, whereas a 243% increase of fluoroquinolone use increased acquisition of FCRE. Content Type Journal ArticleCategory OriginalDOI 10.1007/s00134-009-1714-yAuthors Saskia Nijssen, St. Elisabethziekenhuis Department of Medical Microbiology Hilvarenbeekse Weg 60 5022 GC Tilburg The NetherlandsAd Fluit, University Medical Center Utrecht Department of Medical Microbiology, Julius Center for Health Sciences and Primary Care Heidelberglaan 100 3584 CX Utrecht The NetherlandsDavid van de Vijver, Erasmus Medic...
Source: Intensive Care Medicine - November 18, 2009 Category: Intensive Care Tags: Intensive Care Medicine Source Type: journals

Efficacy profile of daptomycin for the treatment of invasive as compared to non-invasive pulmonary infections with S. pneumoniae.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Daptomycin is a novel lipopeptide antibiotic with excellent activity against Gram-positive bacterial pathogens, but its therapeutic value for the treatment of invasive pneumococcal disease as compared to pneumococcal pneumonia is incompletely defined. We investigated the efficacy of daptomycin in two models of S. pneumoniae-induced lung infection, i.e., pneumococcal pneumonia or septic pneumococcal disease. Mice were infected with bioluminescent, invasive serotype 2 or less virulent serotype 19 S. pneumoniae, followed by semi-therapeutic or therapeutic daptomycin or ceftriaxone treatment. Readouts included survival, ba...
Source: Antimicrobial Agents and Chemotherapy - November 16, 2009 Category: Microbiology Authors: Henken S, Bohling J, Martens-Lobenhoffer J, Paton JC, Ogunniyi AD, Briles DE, Salisbury VC, Wedekind D, Bode-Böger SM, Welsh T, Bange F, Welte T, Maus UA Tags: Antimicrob Agents Chemother Source Type: journals

False-positive widal in melioidosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Valsalan Rohith, Shubha S, Mukhopadhyay C, Saravu K, Maneesh M, Shastry B A, Rau N R, Pandit V R, Gonsalves HazelIndian Journal of Medical Sciences 2009 63(10):464-467Enteric fever is endemic in this part of the world, and Widal test is one of the time-honored laboratory tests that are being used for years to diagnose the disease. On the other hand, melioidosis is a newly emerging disease from this region, which is most often misdiagnosed or underdiagnosed by clinicians. It is well accepted that false-positive Widal reactions following certain non-typhoid Salmonella infections may occur commonly. Three cases of high titers...
Source: Indian Journal of Medical Sciences - November 7, 2009 Category: Journals (General) Authors: Valsalan Rohith, Shubha S, Mukhopadhyay C, Saravu K, Maneesh M, Shastry B A, Rau N R, Pandit V R, Gonsalves Hazel Source Type: journals

What Evaluation is Appropriate for Complex Febrile Seizures?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion Febrile seizures are the most common type of seizures in children. They affect about 2-5% of all children. Febrile seizures are characterized into two groups: simple febrile seizures and complex febrile seizures. Basically, if the child does not meet the criteria for a simple febrile seizure it is called a complex febrile seizure. The main characteristics are outlined below: Simple Febrile Seizure Complex Febrile Seizure Age 6-60 months < 6 months or > 60 months Duration < 15 minutes > 15 minutes Type Generalized Focal seizures tonic-clonic Tonic and/or clonic Partial se...
Source: PediatricEducation.org - November 2, 2009 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: info

Incompatibility of Ceftriaxone Sodium with Calcium-containing Products.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The purpose of this study was to evaluate the incompatibility of ceftriaxone with calcium-containing products, which had been the subject of an ALERT issued by the FDA. The influence of calcium ion concentration, storage temperature and shaking on the appearance and quantity of insoluble microparticles in mixtures of the two was examined using a light obscuration particle counter and a stereomicroscope. Appropriate volumes of 2% (w/v) calcium chloride solution were added to ceftriaxone sodium for injection (10 mg/ml) to make solutions with final calcium ion concentrations of 0.5-2.5 mmol/l, and stored at 20 degrees C, ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - November 1, 2009 Category: Drugs & Pharmacology Authors: Nakai Y, Tokuyama E, Yoshida M, Uchida T Tags: Yakugaku Zasshi Source Type: journals

Interleukin-10/Ceftriaxone prevents E.Coli-induced delays in sensorimotor task learning and spatial memory in neonatal and adult Sprague Dawley rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Intrauterine infection during pregnancy is associated with early activation of the fetal immune system and poor neurodevelopmental outcomes. Immune activation can lead to alterations in sensorimotor skills, changes in learning and memory and neural plasticity. Both interleukin-10 (IL-10) and Ceftriaxone have been shown to decrease immune system activation and increase memory capacity, respectively. Using a rodent model of intrauterine infection, we examined sensorimotor development in pups, learning and memory, via the Morris water maze, and long-term potentiation in adult rats. Pregnant rats at gestational day 17 were...
Source: Brain Research Bulletin - October 30, 2009 Category: Neurology Authors: Wallace KL, Lopez J, Shaffery JP, Paul IA, Bennett WA Tags: Brain Res Bull Source Type: journals

Recurrent systemic infections with Streptococcus pneumoniae do not aggravate the course of experimental neurodegenerative diseasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, onset and course of disease in mouse models of three common neurodegenerative disorders were not influenced by repeated systemic infections with S. pneumoniae, indicating that the effect of moderately severe acute infections on the course of neurodegenerative diseases may be less pronounced than suspected. © 2009 Wiley-Liss, Inc. (Source: Journal of Neuroscience Research)
Source: Journal of Neuroscience Research - October 27, 2009 Category: Neuroscience Authors: Sandra Ebert, Miriam Goos, Lena Rollwagen, Daniel Baake, Wolf-Dieter Zech, Hermann Esselmann, Jens Wiltfang, Brit Mollenhauer, Reinhard Schliebs, Joachim Gerber, Roland Nau Source Type: journals

Health Canada updates ceftriaxone prescribing informationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - October 26, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Rocephin 250mg, 1g, 2g vials (ceftriaxone) - Revised SPCEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: eMC (electronic Medicines Compendium) Area: Other Library Updates > SPC Changes Revised SPC includes updates to: Section 4.2 (method of administration) - Diluents containing calcium, (e.g. Ringer's solution or Hartmann's solution), should not be used to reconstitute ceftriaxone vials or to further dilute a reconstituted vial for IV administration because a precipitate can form. Precipitation of ceftriaxone-calcium can also occur when ceftriaxone is mixed with calcium-containing solutions in the same IV administration line. Therefore, ceftriaxone and calcium-containing solutions must not be mixed or administere...
Source: NeLM - SPC Changes - October 26, 2009 Category: Drugs & Pharmacology Source Type: organizations

Prevalence of serotypes and antimicrobial resistance of invasive strains of pneumococcus in children: analysis of 9 years.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Penicillin resistance was detected in 9.9% of the strains, being predominant from 2004 to 2008. Twenty different pneumococcal serotypes were identified, and 71.9% of the serotypes were represented in the 7-valent conjugate vaccine (PN CRM7) currently available. PMID: 19859623 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - October 26, 2009 Category: Pediatrics Authors: Mantese OC, de Paula A, Almeida VV, de Aguiar PA, Wolkers PC, Alvares JR, Almeida SC, Guerra ML, Brandileone MC Tags: J Pediatr (Rio J) Source Type: journals

Community-acquired Acinetobacter baumannii meningitis in a previously healthy 14-month-old boyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a previously healthy 14-month-old boy who developed community-acquired Acinetobacter baumannii meningitis. He had no history of immunodeficiency, and was brought to Konan Kosei Hospital with a high fever and vomiting. His consciousness was clear, but neck stiffness was noted. Examination of the cerebrospinal fluid (CSF) revealed a cell count of 10 112/µl; protein, 216 mg/dl; and glucose, 9 mg/dl. A CSF test kit for bacterial capsular antigens (Pastorex Meningitis; Bio-Rad Laboratories) was positive for Haemophilus influenzae type b antigen. On day 3 of admission, the microorganism isolated by CSF culture was ...
Source: Journal of Infection and Chemotherapy - October 24, 2009 Category: Infectious Diseases Tags: Journal of Infection and Chemotherapy Source Type: journals

Empiric antibiotic therapy in acute uncomplicated urinary tract infections and fluoroquinolone resistance: a prospective observational studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: The aims of this study were to determine the antimicrobial susceptibility patterns of urinary isolates from community acquired acute uncomplicated urinary tract infections (uUTI) and to evaluate which antibiotics were empirically prescribed in the outpatient management of uUTI. Methods: Among the patients which were admitted to outpatient clinics of Ankara University Medical Faculty, Ibni-Sina Hospital during 2005-2006, a total of 429 women between the age of 18 and 65 years old who were clinically diagnosed with uUTI and to whom prescribed empirical antibiotics were enrolled in this prospective observational s...
Source: BioMed Central - October 23, 2009 Category: Journals (General) Authors: Cenk AypakAdalet AltunsoyNursen Duzgun Source Type: journals

Beta-Lactam Resistance in Salmonella Isolated from Retail Meats in the United States: National Antimicrobial Resistance Monitoring System (NARMS): 2002-2006.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ampicillin-resistant (AMP(R)) Salmonella (n=344) representing 32 serotypes isolated from retail meats from 2002-2006 were tested for susceptibility to 21 other antimicrobial agents, and screened for the presence of five beta-lactamase gene families (blaCMY, blaTEM, blaSHV, blaOXA, blaCTX-M) and class 1 integrons. Among the AMP(R) isolates, 66.9% were resistant to >/=5 antimicrobials and 4.9% to >/= 10 antimicrobials. Co-resistance to other beta-lactams was noted for amoxicillin/clavulanic acid (55.5%), ceftiofur (50%), cefoxitin (50%), and ceftazidime (24.7%), whereas less than 5% of isolates were resistant to pi...
Source: Applied and Environmental Microbiology - October 23, 2009 Category: Microbiology Authors: Zhao S, Blickenstaff K, Glenn A, Ayers SL, Friedman SL, Abbott JW, McDermott PF Tags: Appl Environ Microbiol Source Type: journals

MHRA highlights interaction between ceftriaxone and calciumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - October 19, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Med Sci Monit 2009; 15(11):CR579-582 "Susceptibility pattern of E. coli-associated urinary tract infection (UTI): A comparison of spinal cord injury-related and nosocomial UTI"Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Despite more risk factors for antibiotic-resistant E. coli in SCI patients, antibiotic-resistant E. coli was observed more in nosocomial UTIs, which may be attributable to the hospital environment. (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 19, 2009 Category: Research Tags: Original article Source Type: journals

Polyserositis due to Salmonellaenterica serovar EnteritidisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: Salmonella enterica serovar Enteritidis (S. Enteritidis), a non-typhoid Salmonella, is an important emerging pathogen that usually causes gastroenteritis. Here, we report polyserositis with right-sided pleural effusion and loculated collection of fluid in the peritoneum caused by S. Enteritidis in a 60-year-old man from southern India. The patient was immunocompetent and did not have preceding gastroenteritis or any local structural abnormality. Malnutrition and old age might have been the predisposing factors. The patient received intravenous ceftriaxone for 2 weeks followed by oral ciprofloxacin. Pleurocentesis ...
Source: Transactions of the Royal Society of Tropical Medicine and Hygiene - October 16, 2009 Category: Tropical Medicine Authors: V. Lakshmaiah, M.S. Arun, A. Malini, S.R. Prasad Tags: Case Report Source Type: journals

A Meta-Analysis of Randomized Controlled Trials Assessing the Prophylactic Use of Ceftriaxone. A Study of Wound, Chest and Urinary InfectionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleCategory Invited CommentaryDOI 10.1007/s00268-009-0232-yAuthors Markus Schäfer, University Hospital Department of Visceral and Transplantation Surgery Rämistrasse 100 8091 Zürich SwitzerlandPierre-Alain Clavien, University Hospital Department of Visceral and Transplantation Surgery Rämistrasse 100 8091 Zürich Switzerland Journal World Journal of SurgeryOnline ISSN 1432-2323Print ISSN 0364-2313 (Source: World Journal of Surgery)
Source: World Journal of Surgery - October 13, 2009 Category: Surgery Tags: World Journal of Surgery Source Type: journals

FDA releases quarterly list of early investigations into potential adverse drug reactions identified between January and March 2009Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: FDA, Reuters Health News Area: News The FDA has published its quarterly list of safety probes, which forms part of the effort to inform the public about early investigations into potential adverse drug reactions that have been reported. The current list covers issues identified between January and March 2009 as follows: 1. Ceftriaxone (Rocephin®): Hemolytic anaemia 2. Diclofenac epolamine patch (Flector®): Hypersensitivity reactions 3. Didanosine (Videx®): Portal hypertension 4. Entacapone (Comtan): Colitis 5. Gadolinium-based contrast agents: Anaphylaxis 6. Alph...
Source: NeLM - News - October 8, 2009 Category: Drugs & Pharmacology Source Type: organizations

MHRA Drug Safety Update October 2009: Incompatibility of ceftriaxone (Rocephin®) with calcium containing solutionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: MHRA Area: Evidence > Medication Safety In November 2007, the MHRA advised healthcare professionals that ceftriaxone should not be mixed or simultaneously infused with calcium-containing solutions such as Hartmann's or Ringer's because of a risk of precipitation. It also advised that ceftriaxone is contraindicated in newborns who need calcium treatment because of a risk of precipitation of ceftriaxone calcium salt. Following a review of data, the October issue of the MHRA's Drug Safety Update provides a reminder and further advice for healthcare professionals as follows: . Ceftriaxone is contraindi...
Source: NeLM - Patient Safety - October 7, 2009 Category: Drugs & Pharmacology Source Type: organizations

Health-care associated infections rates, length of stay, and bacterial resistance in an intensive care unit of Morocco: Findings of the International Nosocomial Infection Control Consortium (INICC)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: HAI rates, LOS, mortality, and bacterial resistance were high. Even if data may not reflect accurately the clinical setting of the country, programs including surveillance, infection control, and antibiotic policy are a priority in Morocco. (Source: International Archives of Medicine)
Source: International Archives of Medicine - October 6, 2009 Category: Global & Universal Authors: Naoufel MadaniVictor RosenthalTarik DendaneKhalid AbidiAmine Ali ZeggwaghRedouane Abouqal Source Type: journals

Ceftriaxone: Agranulocytosis: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - October 6, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Simultaneous multiresponse optimization of an HPLC method to separate seven cephalosporins in plasma and amniotic fluid: application to validation and quantification of cefepime, cefixime and cefoperazone.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An HPLC method for the separation of seven cephalosporins [Cefepime (CEP), ceftazidime (CTA), ceftizaxime (CTI), ceftriaxone (CTR), cefotaxime (COT), cefixime (CIX) and cefoperazone (COP)] in human plasma and amniotic fluid has been developed. Optimization of the chromatographic method was performed in three steps: a series of initial experiments followed by two sets of experiments based on different experimental designs. The initial experiments were performed to decide the basic analytical requirements of the method. Then screening experiment fractional factorial design was used in order to decrease the number of para...
Source: Talanta - September 30, 2009 Category: Chemistry Authors: Nemutlu E, Kir S, Katlan D, Beksaç MS Tags: Talanta Source Type: journals

Changing trends in antimicrobial resistance of Salmonella enterica serovar typhi and salmonella enterica serovar paratyphi A in Chennai.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The study indicates reemergence of chloramphenicol-susceptible Salmonella enterica serovar typhi and paratyphi A isolates, a significant decline in MDR strains and high resistance to nalidixic acid. E1 phage type and biotype 1 are found to be most prevalent in Chennai, India. PMID: 19805957 [PubMed - in process] (Source: Indian Journal of Pathology and Microbiology)
Source: Indian Journal of Pathology and Microbiology - September 30, 2009 Category: Pathology Authors: Krishnan P, Stalin M, Balasubramanian S Tags: Indian J Pathol Microbiol Source Type: journals

Infective endocarditis caused by Salmonella enteritidis in a dialysis patient: a case report and literature reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Although there are several reports that Salmonella endocarditis without cardiac failure can be successfully treated with antibiotics alone, early surgical intervention is essential for some cases to prevent life-threatening complications. Transesophageal echocardiography should be performed in any patient with high clinical suspicion of infective endocarditis for the early detection and the early surgical intervention. To the best of our knowledge, this is the first case-report of Salmonella endocarditis in a haemodialysis patient. (Source: BMC Infectious Diseases)
Source: BMC Infectious Diseases - September 28, 2009 Category: Infectious Diseases Authors: Yusuke TsugawaMiyuki FutatsuyamaKeiichi FurukawaFumika TakiYuji NishizakiKeiichi TamagakiYuki KaneshiroYasuhiro Komatsu Source Type: journals

Two Phase 3 Trials Show Benefits of Ceftaroline for Community-Acquired PneumoniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Two phase 3 trials show ceftaroline is equivalent to ceftriaxone in treating community-acquired pneumonia, but some have expressed doubts about the potency and applicability of the new antibiotic. Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 22, 2009 Category: Consumer Health News Tags: Infectious Diseases Source Type: news

Bacteremia in febrile nonneutropenic pediatric oncology patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We sought to determine the risk of bacteremia in a cohort of outpatient febrile nonneutropenic pediatric oncology patients and to assess clinical characteristics that may influence decisions regarding empiric antibiotic therapy.A single institution retrospective cohort study was performed of outpatient pediatric oncology patients presenting with fever, a central venous catheter, and an absolute neutrophil count (ANC) of [ge]500/µl over a 6-year period. We also collected data regarding the presence of clinically evident infections, antibiotics prescribed, and the sensitivity of bacteria to specific antibiotics.There were 2...
Source: Pediatric Blood and Cancer - September 21, 2009 Category: Cancer & Oncology Authors: Michael J. Kelly, Patrick M. Vivier, Tali M. Panken, Cindy L. Schwartz Source Type: journals

Multidrug-resistant Neisseria gonorrhoeae with reduced cefotaxime susceptibility is increasingly common in men who have sex with men, Amsterdam, the Netherlands.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Antimicrobial resistance is an increasing problem in Neisseria gonorrhoeae (NG) treatment. Presently, third-generation parenteral cephalosporins, like ceftriaxone and cefotaxime, are the first option. Resistance to oral, but not to parenteral, third-generation cephalosporins has been reported previously. We analysed the microbial susceptibility (as minimum inhibitory concentration - MIC) of NG cultures obtained from high-risk visitors of the largest Dutch outpatient clinic for sexually transmitted infections (STI) in Amsterdam, the Netherlands. Among 1,596 visitors, we identified 102 patients with at least one NG isola...
Source: Euro Surveill - September 20, 2009 Category: Infectious Diseases Authors: de Vries HJ, van der Helm JJ, Schim van der Loeff MF, van Dam AP Tags: Euro Surveill Source Type: journals

Neurobrucellosis: an evaluation of a rare presentation of brucellosis from a tertiary care centre in Central Anatolia, Turkey.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe our experience of the diagnosis, treatment and final outcome of patients with neurobrucellosis at the Erciyes University Gevher Nesibe Hospital, a tertiary referral centre in Central Anatolia, Turkey. Thirty-six adult patients were diagnosed with neurobrucellosis from January 1997 to December 2006. Headache and fever were the most common symptoms. Neck stiffness was present in 25 patients. Brucella spp was isolated from the blood of nine patients and from the cerebrospinal fluid of 11. Doxycycline (by mouth) plus rifampin (by mouth) with ceftriaxone (intravenously) were the most common treatment choices. Three ...
Source: Tropical Doctor - September 20, 2009 Category: Tropical Medicine Authors: Demiraslan H, Metan G, Mese EA, Yildiz O, Aygen B, Sumerkan B, Doganay M Tags: Trop Doct Source Type: journals

Multidrug-resistant Neisseria gonorrhoeae with reduced cefotaxime susceptibility is increasingly common in men who have sex with men, Amsterdam, the NetherlandsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Antimicrobial resistance is an increasing problem in Neisseria gonorrhoeae (NG) treatment. Presently, third-generation parenteral cephalosporins, like ceftriaxone and cefotaxime, are the first option. Resistance to oral, but not to parenteral, third-generation cephalosporins has been reported previously. We analysed the microbial susceptibility (as minimum inhibitory concentration - MIC) of NG cultures obtained from high-risk visitors of the largest Dutch outpatient clinic for sexually transmitted infections (STI) in Amsterdam, the Netherlands. Among 1,596 visitors, we identified 102 patients with at least one NG isolate w...
Source: Eurosurveillance latest news - September 17, 2009 Category: Infectious Diseases Source Type: journals

What Are Some Common Presentations for Inborn Errors of Metabolism?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion Each inborn errors of metabolism (IEM) by itself is often rare but taken as a whole, IEM are common. IEM often present in the newborn or infancy periods but can present at any time including adulthood. The genetic defect often causes a problem in the catabolism or synthesis of carbohydrates, fats, or proteins. The defect causes a blockage in the metabolic pathway with intermediate molecules accumulating (often toxic accumulations) before the blockage and metabolites after the blockage being scarce (inadequate energy production/utilization). Diet and stresses including surgery, trauma, and illness often can trigg...
Source: PediatricEducation.org - September 14, 2009 Category: Pediatrics Authors: Donna M. D'Alessandro, M.D. Tags: Uncategorized Source Type: info

Cost-Effectiveness of Ceftriaxone and Amikacin as Single Daily Dose for the Empirical Management of Febrile Granulocytopenic Children with CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chemotherapy 1997;43:358-366 (DOI:10.1159/000239590) (Source: Chemotherapy)
Source: Chemotherapy - September 10, 2009 Category: Cancer & Oncology Source Type: journals

Neisseria gonorrhoeae antibiotic resistance in Paris, 2005 to 2007: implications for treatment guidelines.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to appraise: (i) the antimicrobial susceptibility of Neisseria gonorrhoeae in a venereology clinic in Paris, between 2005 and 2007; and (ii) the factors associated with quinolone-resistant N. gonorrhoeae. A prospective study of consecutive cases was performed for the period 2005 to 2007. Susceptibility of N. gonorrhoeae to five antibiotics (ciprofloxacin, ceftriaxone, spectinomycin, penicillin G and tetracycline) was tested systematically. Clinical and epidemiological data were collected using a standardized form. Male-to-female sex ratio was 22.0. Median age was 30.0 years. Of 115 cases, 84...
Source: Acta Derm Venereol A... - September 9, 2009 Category: Dermatology Authors: Farhi D, Hotz C, Poupet H, Gerhardt P, Morand P, Poyart C, Sednaoui P, Avril MF, Dupin N Tags: Acta Derm Venereol Source Type: journals

Induction of Nrf2 and xCT are involved in the action of the neuroprotective antibiotic ceftriaxone in vitroEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In amyotrophic lateral sclerosis, down-regulation of the astrocyte-specific glutamate excitatory amino acid transporter 2 is hypothesized to increase extracellular glutamate, thereby leading to excitotoxic motor neuron death. The antibiotic ceftriaxone was recently reported to induce excitatory amino acid transporter 2 and to prolong the survival of mutant superoxide dismutase 1 transgenic mice. Here we show that ceftriaxone also protects fibroblasts and the hippocampal cell line HT22, which are not sensitive to excitotoxicity, against oxidative glutamate toxicity, where extracellular glutamate blocks cystine import via th...
Source: Journal of Neurochemistry - September 7, 2009 Category: Neurology Authors: Jan Lewerenz, Philipp Albrecht, Mai-Ly Tran Tien, Nadine Henke, Saravanan Karumbayaram, Harley I. Kornblum, Martina Wiedau-Pazos, Dave Schubert, Pamela Maher, Axel Methner Source Type: journals

Environmental risk assessment of antibiotics: An intensive care unit analysis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hospital effluents have been usually known by the microbiological pollution they cause, but only recently they have been considered a significant source of aquatic environmental pollution due to the presence of medicines in these effluents. In this context, an environmental risk assessment (ERA) is presented for the most used intravenous antibiotics in the Intensive Care Unit (ICU) of a hospital in Curitiba (Brazil). The amount of antibiotics used in the ICU was evaluated during 18months (June 2006 until November 2007), in order to calculate the Predicted Environmental Concentration (PEC1). Antibiotic excretion data (o...
Source: Chemosphere - September 7, 2009 Category: Chemistry Authors: de Souza SM, de Vasconcelos EC, Dziedzic M, de Oliveira CM Tags: Chemosphere Source Type: journals

Ceftriaxone: Toxic hepatitis in a child: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - September 7, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Characterization and anti - microbial susceptibility of gram - negative bacteria isolated from bloodstream infections of cancer patients on chemotherapy in PakistanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: High resistance observed in this study warrants the needs of surveillance of resistant pattern of antimicrobial agents. Due to increased level of drug resistance, carbapenem would be a prudent choice in high- risk cases. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - September 4, 2009 Category: Microbiology Authors: Saghir S, Faiz M, Saleem M, Younus A, Aziz H Source Type: journals

Magnitude of drug resistant shigellosis: A report from BangaloreEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Srinivasa H, Baijayanti M, Raksha YIndian Journal of Medical Microbiology 2009 27(4):358-360Shigella is an important cause of acute invasive diarrhea in children and others. Antimicrobial susceptibility of Shigella spp. isolated from diarrhoeal/ dysenteric patients in Bangalore was studied in our hospital from January 2002 to December 2007. One hundred and thirty-four isolates were identified as Shigella species. S. flexneri, S. sonnei...
Source: Indian Journal of Medical Microbiology - September 4, 2009 Category: Microbiology Authors: Srinivasa H, Baijayanti M, Raksha Y Source Type: journals

Efficacy of Short Course,Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: There is no evidence of an increased risk of treatment failure with short course of antibiotics for acute otitis media. Among the short-course regimens, azithromycin use was associated with a lower risk of treatment failure while short-acting oral antibiotics and parenteral ceftriaxone may be associated with a higher risk of treatment failure. PMID: 19736367 [PubMed - as supplied by publisher] (Source: Indian Pediatrics)
Source: Indian Pediatrics - September 2, 2009 Category: Pediatrics Authors: Gulani A, Sachdev HP, Qazi SA Tags: Indian Pediatr Source Type: journals

Renal amyloidosis in Whipple disease: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: To our knowledge based on systematic review, this is the first case report on Whipple disease complicated by secondary amyloidosis and kidney failure maintained on permanent renal replacement therapy. It is strongly suspected that the use of immunosuppressive treatment in such cases may exacerbate the course of Whipple disease and cause life-threatening complications. (Source: Cases Journal)
Source: Cases Journal - August 31, 2009 Category: Journals (General) Source Type: journals

Endogenous Aspergillus Endophthalmitis Occurring After Liver Transplantation: A Case ReportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, we have described a patient who underwent liver transplantation because of drug-induced cholestatic cirrhosis and developed AE at 2 weeks after the surgery. The patient was a 22-year-old man who received a right liver lobe from his father. The operation was uneventful but the patient developed signs and symptoms of small-for-size syndrome after the second day of surgery. The patient received intense immunosuppression with methylprednisolone for 3 days, tacrolimus and mycophenolate mofetil from the first day after the operation, with ceftriaxone and metronidazole as prophylactic antibiotics. Because of signs...
Source: Transplantation Proceedings - August 31, 2009 Category: Transplant Surgery Authors: S.B. Hashemi, M. Shishegar, S. Nikeghbalian, H. Salahi, A. Bahador, K. Kazemi, M. Dehghani, F. Kakaei, S. Gholami, P. Janghorban, S.A. Malek-Hosseini Tags: Case Reports Source Type: journals

Emergence of Extended-Spectrum Beta-Lactamases in Clinical Isolates of Salmonella enterica in Tehran, Iran.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The purpose of the current study was to investigate the presence and molecular type(s) of extended-spectrum beta-lactamases (ESBLs) in Salmonella spp. isolates obtained from patients with diarrhea in hospitals of Tehran, Iran. Over a period of 17 months, 129 Salmonella spp. were isolated from fecal samples and tested for susceptibility using the Kirby-Bauer disk diffusion method; then, screening for ESBL-producing isolates and determination of their minimum inhibitory concentrations were carried out using the combined disk method and standard agar dilution method, respectively. The presence and type of ESBL-encoding ge...
Source: Japanese Journal of Infectious Diseases - August 31, 2009 Category: Infectious Diseases Authors: Hamidian M, Tajbakhsh M, Walther-Rasmussen J, Zali MR Tags: Jpn J Infect Dis Source Type: journals

New susceptibility breakpoints in antimicrobial resistance rates of invasive pneumococcal strains.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: When the new breakpoints for in vitro susceptibility were applied, penicillin resistance rates dropped 97%, from 33 to 1%. PMID: 19830357 [PubMed - in process] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - August 31, 2009 Category: Pediatrics Authors: Wolkers PC, Mantese OC, de Paula A, Almeida VV, de Aguiar PA, Alvares JR, Almeida SC, Brandileone MC Tags: J Pediatr (Rio J) Source Type: journals

Drug interaction software and the risk of using ceftriaxone with therapeutic hemapheresis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19710432 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)
Source: American Journal of Health-System Pharmacy : AJHP - August 29, 2009 Category: Drugs & Pharmacology Authors: Motroni M, Reilly C Tags: Am J Health Syst Pharm Source Type: journals

Brain abscess due to viridans streptococci in a severely immunosuppressed HIV-infected patientEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of viridans streptococcus brain abscess in a severely immunosuppressed HIV-infected patient with a history of chronic sinusitis. A 39-year-old homosexual man showed mental confusion and worsening of a frontal brain lesion after two weeks with antitoxoplasma therapy. Empiric treatment for central nervous system tuberculosis and pyogenic brain abscess was started. He underwent surgical drainage and the diagnosis of brain abscess due to viridans streptococci was confirmed. All empiric treatments were stopped and ceftriaxone was used for eight weeks, showing complete clinical and radiological resolution. Altho...
Source: International Journal of STD and AIDS - August 25, 2009 Category: Global & Universal Authors: Vidal, J E, Tuon, F F Tags: Case reports Source Type: journals

Lyme disease serology in amyotrophic lateral sclerosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lyme disease is sometimes part of the differential diagnosis for amyotrophic lateral sclerosis (ALS). Herein we report on 414 individuals with ALS at the Massachusetts General Hospital who underwent laboratory testing for Lyme disease. Twenty-four (5.8%) were seropositive, but only 4 (0.97%) had confirmed past immunoreactive infection. Two of these patients received ceftriaxone for 1 month without clinical improvement. Lyme disease was rare in 414 patients with ALS and is not likely to be causative. Muscle Nerve, 2009 (Source: Muscle and Nerve)
Source: Muscle and Nerve - August 19, 2009 Category: Internal Medicine Authors: Muddasir Qureshi, Richard S. Bedlack, Merit E. Cudkowicz Source Type: journals

Moxifloxacin is non-inferior to combination therapy with ceftriaxone plus metronidazole in patients with community-origin complicated intra-abdominal infectionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Management of community-origin complicated intra-abdominal infections (cIAIs) requires surgical intervention and antimicrobial therapy. This multinational, randomised, double-blind clinical trial carried out in Asia compared the efficacy and safety of moxifloxacin monotherapy and ceftriaxone/metronidazole combination therapy in adults with confirmed or suspected cIAI. Patients received surgical intervention and either intravenous (i.v.) moxifloxacin 400mg once daily or i.v. ceftriaxone 2g once daily plus i.v. metronidazole 500mg twice daily. A total of 364 patients were randomised [intent-to-treat (ITT), moxiflox...
Source: International Journal of Antimicrobial Agents - August 18, 2009 Category: Drugs & Pharmacology Authors: Joseph Solomkin, Yu-Pei Zhao, En-Ling Ma, Min-Jun Chen, Barbara Hampel, Members of the DRAGON Study Team Tags: Full length articles Source Type: journals

Ceftriaxone: Anaphylaxis managed by desensitisation: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - August 17, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Prophylactic effect of clarithromycin in skin flap complications in cochlear implants surgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To assess the usefulness of postoperative clarithromycin versus classical postoperative prophylaxis with occlusive dressing to prevent cochlear implant skin flap complications.Cohort study.Surgical site infections were compared in four groups: 1) ceramic/classical postoperative cares (21 patients), 2) titanium-silicon/classical postoperative cares (75), 3) ceramic/clarithromycin (24), and 4) titanium-silicon/clarithromycin (76). Preoperative ceftriaxone was systematically used in all patients in all four groups. Patients were followed up for at least 4 months. Attributable risk and number needed to treat were calculated.Al...
Source: The Laryngoscope - August 16, 2009 Category: ENT & OMF Authors: Juan Garcia-Valdecasas, Jose Juan Jiménez-Moleon, Manuel Sainz, Constanza Fornieles, Jose Manuel Ballesteros Source Type: journals

Streptococcus pneumoniae Serotype 3 among Costa Rican Children with Otitis Media: clinical, epidemiological characteristics and antimicrobial resistance patternsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Streptococcus pneumoniae serotype 3 is an important pathogen in Costa Rican children with otitis media, especially in children older than 24 months of age (P=0.05). Most serotype 3 isolates were susceptible to penicillin, cephalosporins, macrolides and quinolones. (Source: BMC Pediatrics - Latest articles)
Source: BMC Pediatrics - Latest articles - August 13, 2009 Category: Pediatrics Authors: Arturo AbdelnourCarolina SoleySilvia GuevaraNurith PoratRon DaganAdriano Arguedas Source Type: journals

Ampicillin plus Ceftriaxone Combination for E. faecalis Orthopedic Infections. A Pilot Study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Serious E. faecalis infections usually require combination therapy to achieve bactericidal effect. In orthopedic infections, the prognosis of enterococcal etiology is considered poor and the use of aminoglycosides questioned. Ampicillin-ceftriaxone combination has recently been accepted as alternative therapy for enterococcal endocarditis. After one of our patients with endocarditis and vertebral osteomyelitis was cured with ampicillin-ceftriaxone, we started a pilot study in orthopedic infections. Patients with infections due to E. faecalis (>/=2 surgical samples or blood cultures) diagnosed during 2005-2008 were r...
Source: Antimicrobial Agents and Chemotherapy - August 9, 2009 Category: Microbiology Authors: Euba G, Lora-Tamayo J, Murillo O, Pedrero S, Cabo J, Verdaguer R, Ariza J Tags: Antimicrob Agents Chemother Source Type: journals