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Decreased expression of serotonin 1A receptor in the dentate gyrus in association with chronic mild stress: A rat model of post-stroke depressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Alterations of serotonin (5-HT) neurotransmission are implicated in post-stroke depression (PSD). Serotonin 1A (5-HT1A) receptor-based abnormalities have been the focus of intensive study in depression. Here we investigated the expression of the 5-HT1A receptor and gene in the hippocampal dentate gyrus (DG) by chronic mild stress (CMS) after stroke and the effect of citalopram. Male Sprague–Dawley rats were separated into control, stress only, ischemic stroke, PSD and citalopram-treated groups. The putative PSD animal model involved cerebral ischemia induced by left middle cerebral artery occlusion (MCAO) follo...
Source: Psychiatry Research - November 20, 2009 Category: Psychiatry Authors: Shao-hua Wang, Zhi-jun Zhang, Yi-jing Guo, Gao-jun Teng, Bao-an Chen Tags: Articles Source Type: journals

Learn About LexaproEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lexapro is one of the SSRI antidepressants and was created from Celexa (citalopram). The generic name of Lexapro is escitalopram, but Lexapro is not currently available in generic form. There are several warnings about Lexapro, especially about mixing it with other drugs and over-the-counter supplements, and discontinuing Lexapro treatment too quickly can cause a variety of unpleasant side effects. Our Lexapro Drug Profile will give you in-depth information about this antidepressant. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Learn more or join the conversation! NEWSLETTER | FOR...
Source: About.com Bipolar Disorder - November 16, 2009 Category: Psychiatry Source Type: consumer

Metabolite identification in rat brain microdialysates by direct infusion nanoelectrospray ionization after desalting on a ZipTip and LTQ/Orbitrap mass spectrometry.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Analyzing brain microdialysate samples by mass spectrometry is challenging due to the high salt content of the artificial cerebral spinal fluid (aCSF), low analyte concentrations and small sample volumes collected. A drug and its major metabolites can be examined in brain microdialysates by targeted approaches such as selected reaction monitoring (SRM) which provides selectivity and high sensitivity. However, this approach is not well suited for metabolite profiling in the brain which aims to determine biotransformation pathways. Identifying minor metabolites, or metabolites that arise from brain metabolism, remains a ...
Source: Rapid Communications in Mass Spectrometry : RCM - November 16, 2009 Category: Chemistry Authors: Erve JC, Beyer CE, Manzino L, Talaat RE Tags: Rapid Commun Mass Spectrom Source Type: journals

Differential inhibitory effects of drugs acting at the noradrenaline and 5-hydroxytrptamine transporters in rat and human neocortical synaptosomesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions and implications: This study provides the first compilation of drug potency at native human neocortical SERT and NET. The significant species differences (viz., human vs. rat) in drug potency suggest that the general use of rodent data should be limited to predict clinical efficacy or profile. (Source: British Journal of Pharmacology)
Source: British Journal of Pharmacology - November 13, 2009 Category: Drugs & Pharmacology Authors: M Mantovani, DJ Dooley, A Weyerbrock, R Jackisch, TJ Feuerstein Source Type: journals

Peduncular hallucinosis: A polysomnographic and spect study of a patient and efficacy of serotonergic therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Peduncular hallucinosis (PH) consists of formed and coloured visual images, which the patient knows are unreal; it is often associated with lesions of the pons, midbrain and diencephalon. A 72-year-old man had noted the sudden onset of visual hallucinations one year before, specifying the time and body position in a 4-week, 24-h diary. Thereafter, he underwent video-polysomnography (VPSG), brain magnetic resonance imaging (MRI), angiography (MRA), proton spectroscopy (1H MRS), and single photon emission tomography (SPECT). Patient’s diaries and VPSG showed a strong clustering of hallucinatory experiences during...
Source: Sleep Medicine - November 12, 2009 Category: Sleep Medicine Authors: Roberto Vetrugno, Alessandra Vella, Mario Mascalchi, Maria Alessandria, Roberto D’Angelo, Roberto Gallassi, Riccardo Della Nave, Andrea Ginestroni, Elena Antelmi, Pasquale Montagna Tags: Case Report Source Type: journals

Table of ContentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Rasagiline Treatment Examined for Parkinson's Disease, Efficacy Questions RemainAtomoxetine Augmentation of Cholinesterase Inhibitor Therapy Yields No BenefitsPossible Neuroleptic Malignant Syndrome With Sertraline WithdrawalElderly Citalopram Nonresponders Show Greater Cognitive DeclineGastrointestinal Effects of Rivastigmine Plus Memantine in AD PatientsCommentary on the ADAGIO TrialNew Fact Sheet on Alzheimer's Research ParticipationElderly Driving on the Morning After Use of HypnoticsChorea Induced by Low-Dose GabapentinNew Approval: Guanfacine ERUpdated List of Authorized GenericsSafe Drug Disposal (Source: The Brown ...
Source: The Brown University Geriatric Psychopharmacology Update - November 11, 2009 Category: Geriatrics Source Type: journals

Citalopram: Aggravation of cerebral vasoconstriction?: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - November 11, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Effects of Selective Serotonin Reuptake Inhibitors on Timolol Metabolism in Human Liver Microsomes and Cryo-Preserved HepatocytesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, compounds known to be potent CYP2D6 inhibitors inhibited timolol metabolism in in vitro experiments. The present results strongly suggest that fluoxetine and paroxetine may significantly affect the metabolism of timolol also in vivo and may thus potentiate the adverse cardiovascular effects of topically administered timolol. (Source: Basic and Clinical Pharmacology and Toxicology)
Source: Basic and Clinical Pharmacology and Toxicology - November 11, 2009 Category: Drugs & Pharmacology Authors: Marjo Volotinen, Timo Korjamo, Ari Tolonen, Miia Turpeinen, Olavi Pelkonen, Jukka Hakkola, Jukka Mäenpää Source Type: journals

Cipramil Drops 40mg/mL (citalopram) - Revised SPCEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: eMC (electronic Medicines Compendium) Area: Other Library Updates > SPC Changes Revised SPC, includes updates to: Section 4.4 (Special warnings and precautions for Use) - now includes relevant warnings for serotonin syndrome, hyponatraemia and glaucoma. Section 4.8 (Undesirable Effects) - includes mydriasis (which may lead to acute narrow angle glaucoma). (Source: NeLM - SPC Changes)
Source: NeLM - SPC Changes - November 5, 2009 Category: Drugs & Pharmacology Source Type: organizations

Reduced parahippocampal and lateral temporal GABAA-[11C]flumazenil binding in major depression: preliminary resultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The bilateral reduction in limbic parahippocampal and right temporal [11C]FMZ binding found in MDD indicates decreased GABAA-benzodiazepine receptor complex affinity and/or number. The inverse relationship between GABAA binding in the temporal lobe and HPA axis activity, suggests that HPA axis hyperactivity is partly due to reduced GABA-ergic inhibition. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00259-009-1292-9Authors Ursula M. H. Klumpers, VU University Medical Center Department of Psychiatry Amsterdam The NetherlandsDick J. Veltman, VU University Medical Center Dep...
Source: European Journal of Nuclear Medicine and Molecular Imaging - November 4, 2009 Category: Radiology Tags: European Journal of Nuclear Medicine and Molecular Imaging Source Type: journals

Ziprasidone and Citalopram Use in Pregnancy and Lactation in a Woman With Psychotic Depression [Letters to the Editor]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Am J Psychiatry)
Source: Am J Psychiatry - November 2, 2009 Category: Psychiatry Authors: WERREMEYER, A. Tags: Atypical Neuroleptics Letters to the Editor Source Type: journals

Treating Repetitive Behavior in ASD: Citalopram Not EffectiveEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: AAP Grand Rounds)
Source: AAP Grand Rounds - November 2, 2009 Category: Pediatrics Authors: Schonwald, A. Tags: DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS Source Type: journals

Onset of Citalopram Cardiotoxicity Can Be DelayedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
3 out of 5 stars CITALOPRAM OVERDOSE: LATE PRESENTATION OF TORSADES DE POINTES (TdP) WITH CARDIAC ARREST. Tarabar AF et al. J Med Toxicol 2008;4:101. Abstract Overdose of citalopram (Celexa) — a selective serotonin reuptake inhibitor antidepressant — can produce life-threatening cardiotoxicity. Manifestations include prolonged QTc interval and torsades de pointes. Because these effects are most likely related to a metabolite (didesmethylcitalopram), onset of significant toxicity can be delayed beyond 6 hours. This case report describes a 36-year-old woman who developed transient TdP with syncope 32 hour...
Source: The Poison Review - November 2, 2009 Category: Toxicology Authors: Leon Tags: Medical cardiotoxicity citalopram delayed toxicity Source Type: info

Altering endogenous extracellular serotonin concentrations can modulate network output in the neonatal mouse spinal cord.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Serotonin (5-HT) can potently activate and modulate spinal locomotor circuits in a variety of species. Many of these findings have been obtained by applying serotonin exogenously to the isolated spinal cord of in vitro preparations, which has the drawback of indiscriminately activating extrasynaptic receptors and neurons. To investigate the role of endogenously released serotonin in modulating locomotor networks, the selective serotonin reuptake inhibitor citalopram was used. Fictive locomotion was elicited by either electrical stimulation of the brainstem or the sacral 4 (S4) dorsal root. The addition of 20 muM of cit...
Source: The Journal of Physiology - November 2, 2009 Category: Physiology Authors: Dunbar MJ, Tran MA, Whelan PJ Tags: J Physiol Source Type: journals

Involuntary Emotional Expression DisorderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
, or IEED, is a condition in which a person experiences uncontrollable episodes of emotional expression. That is, they have episodes of crying, laughter, or anger that are not in line with their present mood. The condition is also known as labile affect, pseudobulbar affect, emotional lability, and pathological laughing and crying. It can have a severe impact on the lives of both patients and caregivers, as symptoms may leave sufferers feeling guilty, awkward, embarrassed and reluctant to take part in social interaction. IEED is seen most often following brain injury or in people with dementia, motor neuron disease, and m...
Source: Psych Central - November 1, 2009 Category: Psychiatry Authors: Jane Collingwood Tags: Aging Alzheimer's Antidepressants Caregivers Disorders General Medications Amyotrophic Lateral Amyotrophic Lateral Sclerosis Array Bipolar Bipolar Disorder Brain Injury Deleterious Effect Dementia Depression Anxiety Emotion Source Type: consumer

Ziprasidone and citalopram use in pregnancy and lactation in a woman with psychotic depression.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19884241 [PubMed - in process] (Source: The American Journal of Psychiatry)
Source: The American Journal of Psychiatry - November 1, 2009 Category: Psychiatry Authors: Werremeyer A Tags: Am J Psychiatry Source Type: journals

What Did STAR*D Teach Us? Results From a Large-Scale, Practical, Clinical Trial for Patients With Depression [Special Section on the Implications of STAR*D]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The authors provide an overview of the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study (www.star-d.org), a large-scale practical clinical trial to determine which of several treatments are the most effective "next-steps" for patients with major depressive disorder whose symptoms do not remit or who cannot tolerate an initial treatment and, if needed, ensuing treatments. Entry criteria were broadly defined and inclusive, and patients were enrolled from psychiatric and primary care clinics. All participants began on citalopram and were managed by clinic physicians, who followed an algorithm-guided acute...
Source: Psychiatr Serv - October 30, 2009 Category: Psychiatry Authors: Gaynes, B. N., Warden, D., Trivedi, M. H., Wisniewski, S. R., Fava, M., Rush, A. J. Tags: Health Policy and Legislation, Depression, Research Design, Methodology, Antidepressants Special Section on the Implications of STAR*D Source Type: journals

Pharmacogenetics Studies in STAR*D: Strengths, Limitations, and Results [Special Section on the Implications of STAR*D]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Several lines of evidence support an important genetic contribution to the wide individual variation in therapeutic response to antidepressant medications. The Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study provided the largest cohort assembled to date of DNA from patients with nonpsychotic major depressive disorder, uniformly treated with citalopram and followed prospectively for up to 12 weeks. This pivotal study changed the face of pharmacogenetics research by increasing the sample size by an order of magnitude as well as by providing detailed prospective information about antidepressant response ...
Source: Psychiatr Serv - October 30, 2009 Category: Psychiatry Authors: Laje, G., Perlis, R. H., Rush, A. J., McMahon, F. J. Tags: Depression, Antidepressants Special Section on the Implications of STAR*D Source Type: journals

Attenuation of cocaine-induced reinstatement of drug seeking in squirrel monkeys: kappa opioid and serotonergic mechanismsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Results suggest that the capacity of kappa opioid agonists to increase extracellular 5-HT levels may at least partially underlie kappa agonist-induced modulation of cocaine seeking. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1705-2Authors Daniela Rüedi-Bettschen, Harvard Medical School New England Primate Research Center One Pine Hill Drive P.O. Box 9102 Southborough MA 01772-9102 USAJames K. Rowlett, Harvard Medical School New England Primate Research Center One Pine Hill Drive P.O. Box 9102 Southborough MA 01772-9102 USARoger D. Spealman, Harvard ...
Source: Psychopharmacology - October 26, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

Use of Antidepressants for Management of Hot FlashesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pharmacotherapy 29(11): 1357-1374 Abstract A growing body of evidence suggests that antidepressant therapies, particularly selective serotonin reuptake inhibitors and venlafaxine, are effective in the management of hot flash symptoms. Several of these agents have the support of the American College of Obstetricians and Gynecologists and the North American Menopause Society. To review the literature on antidepressants for the treatment of hot flashes in women, we searched the PubMed, International Pharmaceutical Abstracts, and MEDLINE databases from inception through May 2009. All publication types that included human parti...
Source: Pharmacotherapy: Official Journal of the American College of Clinical Pharmacy - October 26, 2009 Category: Drugs & Pharmacology Authors: Dana G CarrollKristi W Kelley Source Type: journals

Effectiveness and tolerability of citalopram for the treatment of depression and anxiety disorders in children and adolescents: an open-label studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract To assess the effectiveness and tolerability of citalopram for the acute treatment of children and adolescents suffering from depression and/or anxiety disorders. As much as 78 outpatients, aged 7–18 years with a diagnosis of depressive and/or anxiety disorder, completed an 8-week open trial with citalopram (20–40 mg/day). Outcome, side effects and suicidality were assessed weekly to bi-weekly using appropriate rating scales. At endpoint 56% of subjects were found to be responders (Clinical Global Impression-Improvement [CGI-I] Scale ≤ 2). Subjects with less severe psychopa...
Source: Journal of Neural Transmission - October 22, 2009 Category: Neurology Tags: Journal of Neural Transmission Source Type: journals

Monoamines, BDNF, IL-6 and corticosterone in CSF in patients with Parkinson’s disease and major depressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The biochemical basis of major depression (MD) in Parkinson’s disease (PD) is largely unknown. To increase our understanding of MD in PD patients, the levels of monoamine metabolites (HVA, 5-HIAA and MHPG), BDNF, orexin-A, IL-6 and corticosterone were examined in cerebrospinal fluid. The analyses were performed in MD patients with (n = 11) and without (n = 12) PD at baseline and after 12 weeks’ of treatment with the antidepressant citalopram, and in patients with solely PD (n = 14) at baseline and after 12 weeks. The major findings were that PD patients wit...
Source: Journal of Neurology - October 21, 2009 Category: Neurology Tags: Journal of Neurology Source Type: journals

Serotonergic and Noradrenergic Modulation of Emotion Processing by Single Dose AntidepressantsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
& Uwe Herwig Keywords: emotion processing, citalopram, reboxetine, functional imaging, depression, treatment (Source: Neuropsychopharmacology)
Source: Neuropsychopharmacology - October 20, 2009 Category: Neurology Authors: Annette Beatrix BrühlTina KaffenbergerUwe Herwig Source Type: journals

Effects of Lorazepam and citalopram on human defensive reactions: ethopharmacological differentiation of fear and anxiety. - Perkins AM, Ettinger U, Davis R, Foster R, Williams SC, Corr PJ.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Drugs that are clinically effective against generalized anxiety disorder preferentially alter rodent risk assessment behavior, whereas drugs that are clinically effective against panic disorder preferentially alter rodent flight behavior. The theoretical p... (Source: SafetyLit: All (Unduplicated))
Source: SafetyLit: All (Unduplicated) - October 18, 2009 Category: Global & Universal Tags: Risk Perception and Communication, Warnings, Operating Instructions Source Type: info

Targacept's P.2b depression study succeeds: 6-point difference on HAM-DEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Linnden Communications) Targacept Inc., a clinical-stage biopharmaceutical company developing a new class of drugs known as NNR Therapeutics, today announced the presentation of data from its recently completed Phase 2b clinical trial of TC-5214 as an augmentation treatment in subjects with major depressive disorder, or MDD, who did not respond adequately to first-line treatment with the representative SSRI citalopram hydrobromide. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - October 16, 2009 Category: Global & Universal Source Type: news

Evaluation of the influence of sex and CYP2C19 and CYP2D6 polymorphisms in the disposition of citalopram.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, we demonstrate the influence of CYP2C19 and CYP2D6 in the disposition of citalopram, and we suggest that the influence of CYP2D6 is more probable in volunteers with at least one defective allele of CYP2C19. PMID: 19840783 [PubMed - as supplied by publisher] (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - October 15, 2009 Category: Drugs & Pharmacology Authors: Fudio S, Borobia AM, Piñana E, Ramírez E, Tabarés B, Guerra P, Carcas A, Frías J Tags: Eur J Pharmacol Source Type: journals

Clinical and ECG Effects of Escitalopram OverdoseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
2.5 out of 5 stars CLINICAL AND ECG EFFECTS OF ESCITALOPRAM OVERDOSE van Gorp et al. Ann Emerg Med September 2009;54:404-408. Abstract This Australian study reviewed 79 presentations (68 patients) of patients admitted to a toxicology unit with escitalopram overdose. in 46 of these, there were no significant co-ingestants. Ingested doses of escitalopram ranged from 20 – 560 mg. In this group there was no occurence of death, arrhythmia, or seizures. Potentially significant effects included clonus and hyperreflexia (representing serotonin effect) and prolonged QT interval. Escitalopram (Lexapro) in the S-ena...
Source: The Poison Review - October 13, 2009 Category: Toxicology Authors: Leon Tags: Medical antidepressant escitalopram SSRI Source Type: info

Citalopram/paroxetine: Bruxism: 2 case reportsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - October 12, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Acamprosate/citalopram/cyamemazine/dipotassium clorazepate withdrawal: Catatonia: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - October 6, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Citalopram: First report of central retinal vein occlusion: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - September 30, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Sibutramine overdose: Multiple toxicities, including those due to interactions with atomoxetine, methylphenidate and citalopram: 17 case reportsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - September 30, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

CITALOPRAM HYDROBROMIDEsolution [Aurobindo Pharma Limited]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Sep 30, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - September 30, 2009 Category: Drugs & Pharmacology Source Type: organizations

Cipramil (citalopram) Tablets - Revised SPCEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: eMC (electronic Medicines Compendium) Area: Other Library Updates > SPC Changes Section 4.4 (special warnings and precautions for use) has been updated to include relevant warnings for serotonin syndrome, hyponatraemia and glaucoma. Section 4.8 (undesirable effects) has been updated to include mydriasis (which may lead to acute narrow angle glaucoma). (Source: NeLM - SPC Changes)
Source: NeLM - SPC Changes - September 27, 2009 Category: Drugs & Pharmacology Source Type: organizations

Antidepressants and pregnancyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was not able to remove the possible effects of depression itself, as it was not able to identify and compare pregnant women with depression who were not taking antidepressants. This study was based on national databases of records about prescriptions, births and medical diagnoses. Some of the information in these databases may have been misrecorded or missed. It is possible that the newborns of those women known to be taking prescription drugs, may have been more thoroughly examined for defects at birth, which would tend to bias towards finding more defects in this group. However, the overall proportion of...
Source: NHS News Feed - September 25, 2009 Category: Consumer Health News Tags: Mental health Pregnancy/child Source Type: news

Maternal Use of Sertaline, Citalopram Linked to Septal Heart Defects in OffspringEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - September 24, 2009 Category: Primary Care Tags: Medical News Source Type: info

Selective serotonin reuptake inhibitors in pregnancy and congenital malformations: population based cohort studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: BMJ Area: News According to research published early online in the British Medical Journal, there is an increased prevalence of septal heart defects among children whose mothers were prescribed a selective serotonin reuptake inhibitors SSRI in early pregnancy, particularly sertraline and citalopram. The population based cohort study incorporated data based on 494,483 children born in Denmark during the period 1996 to 2003 (493,113 unexposed infants, and 1,370 exposed infants). Researchers sought to evaluate associations between SSRI use during the first trimester of pregnancy, and major malformati...
Source: NeLM - News - September 23, 2009 Category: Drugs & Pharmacology Source Type: organizations

Citalopram: Thrombocytopenia and haemorrhage: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - September 21, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Citalopram/tramadol: Serotonin syndrome in an elderly patient: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - September 21, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

The synergistic interaction between morphine and maprotiline after intrathecal injection in rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Selective norepinephrine reuptake inhibitors can significantly increase the intensity and duration of morphine antinociceptive activity via both alpha(2)-adrenergic and opioid receptors. This interaction was not observed with the selective serotonin inhibitor, citalopram. PMID: 19762762 [PubMed - in process] (Source: Anesthesia and Analgesia)
Source: Anesthesia and Analgesia - September 20, 2009 Category: Anesthesiology Authors: Pettersen VL, Zapata-Sudo G, Raimundo JM, Trachez MM, Sudo RT Tags: Anesth Analg Source Type: journals

Chronic therapy with citalopram decreases regional cerebral glucose utilization in OBX, and not sham-operated, rats: an autoradiographic studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion The results imply that chronic citalopram treatment, shown previously to result in behavioral normalization in OBX rats, establishes a new pattern of rCGU, rather than normalizing it to the pattern of the sham-CTP rats. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1659-4Authors Ivan Skelin, McGill University Cone Neurological Research laboratory, Department of Neurology and Neurosurgery 3801 University St. Montreal QC H3A2B4 CanadaHiroki Sato, McGill University Cone Neurological Research laboratory, Department of Neurology and Neurosurgery 3801 University...
Source: Psychopharmacology - September 17, 2009 Category: Psychiatry Tags: Psychopharmacology Source Type: journals

The effect of serotonergic and noradrenergic antidepressants on face emotion processing in depressed patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Antidepressants altered emotional processing in depressed patients with some similarities to the effects seen in healthy volunteers. The largest effect seen was increased recognition of disgust that may be specific to depressed patients. The correlation between increased accurate recognition of happy faces at two-weeks of treatment and clinical outcome at six-weeks of treatment suggests that early changes in emotional processing may underlie clinical response to antidepressants. (Source: Journal of Affective Disorders)
Source: Journal of Affective Disorders - September 14, 2009 Category: Neurology Authors: Richard Tranter, Diana Bell, Petra Gutting, Catherine Harmer, David Healy, Ian M. Anderson Tags: Research reports Source Type: journals

Citalopram: Herpes zoster (first report) in an elderly patient: 2 case reportsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - September 14, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Effects of escitalopram in overdoseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Ann Emerg Med Area: News A case report paper discusses the main symptoms of escitalopram overdose based on 79 presentations. Cardiac effects are unusual with SSRI overdose, however they have been reported with citalopram. The authors of this paper comment that there has been limited information on the effects of escitalopram in overdose. They therefore report experience with 68 patients who presented 79 times having taken escitalopram in doses between 20mg and 560mg (median 140mg). For 46 presentations, escitalopram was the only drug taken or all other substances taken were non-toxic. Serotonin toxicity...
Source: NeLM - News - September 13, 2009 Category: Drugs & Pharmacology Source Type: organizations

Citalopram efficacy study; interstitial 15q11-q13 duplication mouseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
No Abstract (Source: Autism Research)
Source: Autism Research - September 8, 2009 Category: Psychiatry Authors: Edwin H. Cook Jr. Tags: Literature Review Source Type: journals

Haplotype analysis of single nucleotide polymorphisms in the vascular endothelial growth factor (VEGFA) gene and antidepressant treatment response in major depressive disorderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Vascular endothelial growth factor (VEGF) has been implicated in neurotrophy and neurogenesis, which play a pivotal role in brain development and may be involved in antidepressant therapeutic mechanisms. Recent animal studies demonstrate that VEGF levels are increased by several antidepressants, including selective serotonin reuptake inhibitors, and that VEGF signalling is required for antidepressant-induced behavioural response. We hypothesized that common genetic variants in the VEGF gene (official gene name: VEGFA) may be associated with the therapeutic response to antidepressants in major depressive disorders...
Source: Psychiatry Research - September 7, 2009 Category: Psychiatry Authors: Shih-Jen Tsai, Chen-Jee Hong, Ying-Jay Liou, Tai-Jui Chen, Mao-Liang Chen, Sheue-Jane Hou, Feng-Chang Yen, Younger W.-Y. Yu Tags: Articles Source Type: journals

Antidepressant study design affects patient expectancy: a pilot study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Randomization to comparator versus placebo-controlled administration of antidepressant medication produced greater expectancies of how much patients would improve during the trial. This expectancy difference may explain the higher response and remission rates that are observed in comparator versus placebo-controlled trials. PMID: 19732481 [PubMed - as supplied by publisher] (Source: Psychological Medicine)
Source: Psychological Medicine - September 6, 2009 Category: Psychiatry Authors: Rutherford B, Sneed J, Devanand D, Eisenstadt R, Roose S Tags: Psychol Med Source Type: journals

Serotonergic Modulation of the Trigeminocardiac Reflex Neurotransmission to Cardiac Vagal Neurons in the Nucleus AmbiguusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Stimulation of the trigeminal nerve evokes a dramatic decrease in heart rate and blood pressure, and this reflex has generally been termed the trigeminocardiac reflex. A subset of the trigeminocardiac reflex is the diving reflex in which the nasal mucosa is stimulated with water or air-borne chemical irritants. Activation of the diving reflex evokes a pronounced bradycardia, mediated by increased parasympathetic cardiac activity, and is the most powerful autonomic reflex. However, exaggeration of this protective response could be detrimental and has been implicated in Sudden Infant Death Syndrome (SIDS). Despite the import...
Source: Journal of Neurophysiology - September 1, 2009 Category: Neurology Authors: Gorini, C., Jameson, H. S., Mendelowitz, D. Tags: Articles Source Type: journals

Factors Associated with Concomitant Psychotropic Drug Use in the Treatment of Major Depression: A STAR*D Report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: CPMs are associated with greater illness burden, more Axis I comorbidities (especially anxiety disorders), and lower treatment effectiveness. This suggests that CPM use may identify a more difficult to treat population that needs more aggressive treatment. PMID: 19890231 [PubMed - in process] (Source: CNS Spectrums)
Source: CNS Spectrums - September 1, 2009 Category: Neurology Authors: Shelton RC, Hollon SD, Wisniewski SR, Alpert JE, Balasubramani GK, Friedman ES, Rush AJ, Trivedi MH, Preskorn SH Tags: CNS Spectr Source Type: journals

Table of ContentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Genomewide Study Examines Lithium Response in Patients With Bipolar DisorderNortriptyline Combined With ECT Found Effective for DepressionDrug Metabolism and Fluoxetine: A Case of TrismusPredictors of Sexual Dysfunction in Citalopram-Treated Depressed PatientsVenlafaxine Concentrations in Human Breast Milk and Infant PlasmaGenetic Disorders and Genomewide Association StudiesTranslocator Protein as Target for AnxiolyticsNational Patterns in Antidepressant Medication TreatmentRhabdomyolysis With Clozapine-Lithium CombinationSafety Review of ADHD MedicationsNew Approval: Lamotrigine Extended-ReleaseNew Approval: Invega® Sust...
Source: The Brown University Psychopharmacology Update - August 31, 2009 Category: Psychiatry Source Type: journals

The Mothers Act Disease Mongering Campaign - Part IVEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article says Courtenay publishes a website about "postpartum depression among dads" called "www.saddaddy.com." However, when clicking on the saddaddy link, PostpartumMen comes up today.And surely by coincidence, Courtenay will soon have a new book for sale titled, "Sad Dads," which he is currently writing, according to his bio on the consulting firm's website."If you'd like to arrange an individual consultation with Dr. Courtenay, please call 415-346-6719," the PostpartumMen website states.And apparently postpartum depression in dads is catchy. "If you're experiencing PPND, it increases the likelihood that your partne...
Source: NaturalNews.com - August 27, 2009 Category: Consumer Health Advice Source Type: news