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1705 records returned
Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling
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Kandice R. Levental, Hongmei Yu, Laura Kass, Johnathon N. Lakins, Mikala Egeblad, Janine T. Erler, Sheri F.T. Fong, Katalin Csiszar, Amato Giaccia, Wolfgang Weninger, Mitsuo Yamauchi, David L. Gasser, Valerie M. Weaver. Tumors are characterized by extracellular matrix (ECM) remodeling and stiffening. The importance of ECM remodeling to cancer is appreciated; the relevance of stiffening is less clear. We found tha.... (Source: Cell)
Source: Cell - November 20, 2009 Category: Cytology Source Type: journals
SnapShot: Mouse piRNAs, PIWI Proteins, and the Ping-Pong Cycle
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Jogender S. Tushir, Phillip D. Zamore, Zhao Zhang. (Source: Cell)
Source: Cell - November 13, 2009 Category: Cytology Source Type: journals
Structural Insight into Processive Human Mitochondrial DNA Synthesis and Disease-Related Polymerase Mutations
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Young-Sam Lee, W. Dexter Kennedy, Y. Whitney Yin. (Source: Cell)
Source: Cell - November 13, 2009 Category: Cytology Source Type: journals
Adult Neurogenesis Modulates the Hippocampus-Dependent Period of Associative Fear Memory
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Takashi Kitamura, Yoshito Saitoh, Noriko Takashima, Akiko Murayama, Yosuke Niibori, Hiroshi Ageta, Mariko Sekiguchi, Hiroyuki Sugiyama, Kaoru Inokuchi. SummaryAcquired memory initially depends on the hippocampus (HPC) for the process of cortical permanent memory formation. The mechanisms through which memory becomes progressively independent from.... (Source: Cell)
Source: Cell - November 13, 2009 Category: Cytology Source Type: journals
KIF26A Is an Unconventional Kinesin and Regulates GDNF-Ret Signaling in Enteric Neuronal Development
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Ruyun Zhou, Shinsuke Niwa, Noriko Homma, Yosuke Takei, Nobutaka Hirokawa. The kinesin superfamily proteins (KIFs) are motor proteins that transport organelles and protein complexes in a microtubule- and ATP-dependent manner. We identified KIF26A as a new member of the m.... (Source: Cell)
Source: Cell - November 13, 2009 Category: Cytology Source Type: journals
Cdc42-Mediated Tubulogenesis Controls Cell Specification
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Gokul Kesavan, Fredrik Wolfhagen Sand, Thomas Uwe Greiner, Jenny Kristina Johansson, Sune Kobberup, Xunwei Wu, Cord Brakebusch, Henrik Semb. Understanding how cells polarize and coordinate tubulogenesis during organ formation is a central question in biology. Tubulogenesis often coincides with cell-lineage specification during organ de.... (Source: Cell)
Source: Cell - November 13, 2009 Category: Cytology Source Type: journals
Structural Convergence between Cryo-EM and NMR Reveals Intersubunit Interactions Critical for HIV-1 Capsid Function
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In-Ja L. Byeon, Xin Meng, Jinwon Jung, Gongpu Zhao, Ruifeng Yang, Jinwoo Ahn, Jiong Shi, Jason Concel, Christopher Aiken, Peijun Zhang, Angela M. Gronenborn. Mature HIV-1 particles contain conical-shaped capsids that enclose the viral RNA genome and perform essential functions in the virus life cycle. Previous structural analysis of two- and three-dime.... (Source: Cell)
Source: Cell - November 13, 2009 Category: Cytology Source Type: journals
A trans-Acting Riboswitch Controls Expression of the Virulence Regulator PrfA in Listeria monocytogenes
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Edmund Loh, Olivier Dussurget, Jonas Gripenland, Karolis Vaitkevicius, Teresa Tiensuu, Pierre Mandin, Francis Repoila, Carmen Buchrieser, Pascale Cossart, Jörgen Johansson. Riboswitches are RNA elements acting in cis, controlling expression of their downstream genes through a metabolite-induced alteration of their secondary structure. Here, we demonstrate that.... (Source: Cell)
Source: Cell - November 13, 2009 Category: Cytology Source Type: journals
Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways
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Claudio Alarcón, Alexia-Ileana Zaromytidou, Qiaoran Xi, Sheng Gao, Jianzhong Yu, Sho Fujisawa, Afsar Barlas, Alexandria N. Miller, Katia Manova-Todorova, Maria J. Macias, Gopal Sapkota, Duojia Pan, Joan Massagué. TGF-β and BMP receptor kinases activate Smad transcription factors by C-terminal phosphorylation. We have identified a subsequent agonist-induced phosphorylation that plays a central dual role in .... (Source: Cell)
Source: Cell - November 13, 2009 Category: Cytology Source Type: journals
Structures of Asymmetric ClpX Hexamers Reveal Nucleotide-Dependent Motions in a AAA+ Protein-Unfolding Machine
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Steven E. Glynn, Andreas Martin, Andrew R. Nager, Tania A. Baker, Robert T. Sauer. ClpX is a AAA+ machine that uses the energy of ATP binding and hydrolysis to unfold native proteins and translocate unfolded polypeptides into the ClpP peptidase. The crystal structures presented .... (Source: Cell)
Source: Cell - November 13, 2009 Category: Cytology Source Type: journals
Singularity in Polarization: Rewiring Yeast Cells to Make Two Buds
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Audrey S. Howell, Natasha S. Savage, Sam A. Johnson, Indrani Bose, Allison W. Wagner, Trevin R. Zyla, H. Frederik Nijhout, Michael C. Reed, Andrew B. Goryachev, Daniel J. Lew. For budding yeast to ensure formation of only one bud, cells must polarize toward one, and only one, site. Polarity establishment involves the Rho family GTPase Cdc42, which concentrates at polari.... (Source: Cell)
Source: Cell - November 13, 2009 Category: Cytology Source Type: journals
Nonoptimal Microbial Response to Antibiotics Underlies Suppressive Drug Interactions
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Tobias Bollenbach, Selwyn Quan, Remy Chait, Roy Kishony. Suppressive drug interactions, in which one antibiotic can actually help bacterial cells to grow faster in the presence of another, occur between protein and DNA synthesis inhibitors. Here, we sho.... (Source: Cell)
Source: Cell - November 13, 2009 Category: Cytology Source Type: journals
Dissociation of EphB2 Signaling Pathways Mediating Progenitor Cell Proliferation and Tumor Suppression
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Maria Genander, Michael M. Halford, Nan-Jie Xu, Malin Eriksson, Zuoren Yu, Zhaozhu Qiu, Anna Martling, Gedas Greicius, Sonal Thakar, Timothy Catchpole, Michael J. Chumley, Sofia Zdunek, Chenguang Wang, Torbjörn Holm, Stephen P. Goff, Sven Pettersson, Richard G. Pestell, Mark Henkemeyer, Jonas Frisén. Signaling proteins driving the proliferation of stem and progenitor cells are often encoded by proto-oncogenes. EphB receptors represent a rare exception; they promote cell proliferation in the in.... (Source: Cell)
Source: Cell - November 13, 2009 Category: Cytology Source Type: journals
Centrioles, Centrosomes, and Cilia in Health and Disease
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Erich A. Nigg, Jordan W. Raff. Centrioles are barrel-shaped structures that are essential for the formation of centrosomes, cilia, and flagella. Here we review recent advances in our understanding of the function and biogenesis.... (Source: Cell)
Source: Cell - November 13, 2009 Category: Cytology Source Type: journals
Polarity Is Destiny
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Liang Cai, Keith Mostov. The GTPase Cdc42 specifies polarity in various biological processes. Kesavan et al. (2009) now demonstrate that Cdc42 also regulates epithelial cell polarity in the developing mouse pancreas, wher.... (Source: Cell)
Source: Cell - November 13, 2009 Category: Cytology Source Type: journals
Finale: The Last Minutes of Smads
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Ye-Guang Chen, Xiao-Fan Wang. TGF-β ligands induce phosphorylation of receptor-activated Smads at both the C-terminal tail and the linker region. Two papers from Massagué and colleagues (Alarcón et al., 2009; Gao et al., 2009).... (Source: Cell)
Source: Cell - November 13, 2009 Category: Cytology Source Type: journals
Compete Globally, Bud Locally
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Andrew R. Houk, Arthur Millius, Orion D. Weiner. How cells generate a single axis of polarity for mating, division, and movement is unknown. In this issue, Howell et al. (2009) use a synthetic biology approach to demonstrate that rapid competiti.... (Source: Cell)
Source: Cell - November 13, 2009 Category: Cytology Source Type: journals
Transformation Locked in a Loop
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Jarno Drost, Reuven Agami. During neoplastic transformation, cells can promote their own growth by activating proto-oncogenes. Reporting in Cell, Iliopoulos et al. (2009) now show that in certain cell types, a transi.... (Source: Cell)
Source: Cell - November 13, 2009 Category: Cytology Source Type: journals
Putting Two Heads Together to Unwind DNA
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Thomas J. Takara, Stephen P. Bell. The loading of replicative helicases onto DNA is tightly regulated in all organisms, yet the molecular mechanisms for this event remain poorly defined. Remus et al. (2009) provide important insigh.... (Source: Cell)
Source: Cell - November 13, 2009 Category: Cytology Source Type: journals
Stem Cell Research: Toward Greater Unity in Europe?
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Christiane Druml. There are four major positions on human embryonic stem cell research in the different member states of the European Union, ranging from permissive to very restrictive. This reflects the diversity .... (Source: Cell)
Source: Cell - November 13, 2009 Category: Cytology Source Type: journals
Science, Policy, and the U.S. Congress
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David Goldston. Scientists often misunderstand the role science plays and should play in policy making. Those misconceptions are captured well in the debate over whether Congress should recreate an Office of Tech.... (Source: Cell)
Source: Cell - November 13, 2009 Category: Cytology Source Type: journals
The RAE: An Assessment Too Far?
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Colin Macilwain. A 20 year quantitative assessment of research in British universities has coincided with a renaissance in their international status. But even as other nations seek to emulate the approach, domest.... (Source: Cell)
Source: Cell - November 13, 2009 Category: Cytology Source Type: journals
Molecular Biology Select
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The process of gene expression relies on large macromolecular complexes at almost every step, making mechanistic and structural studies a challenge. This Molecular Biology Select highlights recent.... (Source: Cell)
Source: Cell - November 13, 2009 Category: Cytology Source Type: journals
In This Issue
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(Source: Cell)
Source: Cell - November 13, 2009 Category: Cytology Source Type: journals
Meiotic Chromosome Homology Search Involves Modifications of the Nuclear Envelope Protein Matefin/SUN-1
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Alexandra M. Penkner, Alexandra Fridkin, Jiradet Gloggnitzer, Antoine Baudrimont, Thomas Machacek, Alexander Woglar, Edina Csaszar, Pawel Pasierbek, Gustav Ammerer, Yosef Gruenbaum, Verena Jantsch. Genome haploidization during meiosis depends on recognition and association of parental homologous chromosomes. The C. elegans SUN/KASH domain proteins Matefin/SUN-1 and ZYG-12 have a conse.... (Source: Cell)
Source: Cell - November 13, 2009 Category: Cytology Source Type: journals
Cytoskeletal Forces Span the Nuclear Envelope to Coordinate Meiotic Chromosome Pairing and Synapsis
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Aya Sato, Berith Isaac, Carolyn M. Phillips, Regina Rillo, Peter M. Carlton, David J. Wynne, Roshni A. Kasad, Abby F. Dernburg. During meiosis, each chromosome must pair with its unique homologous partner, a process that usually culminates with the formation of the synaptonemal complex (SC). In the nematode Caenorhabdit.... (Source: Cell)
Source: Cell - November 13, 2009 Category: Cytology Source Type: journals
Concerted Loading of Mcm2–7 Double Hexamers around DNA during DNA Replication Origin Licensing
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Dirk Remus, Fabienne Beuron, Gökhan Tolun, Jack D. Griffith, Edward P. Morris, John F.X. Diffley. The licensing of eukaryotic DNA replication origins, which ensures once-per-cell-cycle replication, involves the loading of six related minichromosome maintenance proteins (Mcm2–7) into prereplica.... (Source: Cell)
Source: Cell - November 6, 2009 Category: Cytology Source Type: journals
SnapShot: Fly piRNAs, PIWI Proteins, and the Ping-Pong Cycle
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Jogender S. Tushir, Phillip D. Zamore, Zhao Zhang. (Source: Cell)
Source: Cell - October 30, 2009 Category: Cytology Source Type: journals
Analysis of Cell Fate from Single-Cell Gene Expression Profiles in C. elegans
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Xiao Liu, Fuhui Long, Hanchuan Peng, Sarah J. Aerni, Min Jiang, Adolfo Sánchez-Blanco, John I. Murray, Elicia Preston, Barbara Mericle, Serafim Batzoglou, Eugene W. Myers, Stuart K. Kim. The C. elegans cell lineage provides a unique opportunity to look at how cell lineage affects patterns of gene expression. We developed an automatic cell lineage analyzer that converts high.... (Source: Cell)
Source: Cell - October 30, 2009 Category: Cytology Source Type: journals
Profiling the Human Protein-DNA Interactome Reveals ERK2 as a Transcriptional Repressor of Interferon Signaling
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Shaohui Hu, Zhi Xie, Akishi Onishi, Xueping Yu, Lizhi Jiang, Jimmy Lin, Hee-sool Rho, Crystal Woodard, Hong Wang, Jun-Seop Jeong, Shunyou Long, Xiaofei He, Herschel Wade, Seth Blackshaw, Jiang Qian, Heng Zhu. Protein-DNA interactions (PDIs) mediate a broad range of functions essential for cellular differentiation, function, and survival. However, it is still a daunting task to comprehensively identify .... (Source: Cell)
Source: Cell - October 30, 2009 Category: Cytology Source Type: journals
Retinoic Acid from the Meninges Regulates Cortical Neuron Generation
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In this study we demonstrate that the dorsal forebrain meninges communicate w.... (Source: Cell)
Source: Cell - October 30, 2009 Category: Cytology Source Type: journals
Polycystin-1 and -2 Dosage Regulates Pressure Sensing
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Reza Sharif-Naeini, Joost H.A. Folgering, Delphine Bichet, Fabrice Duprat, Inger Lauritzen, Malika Arhatte, Martine Jodar, Alexandra Dedman, Franck C. Chatelain, Uwe Schulte, Kevin Retailleau, Laurent Loufrani, Amanda Patel, Frederick Sachs, Patrick Delmas, Dorien J.M. Peters, Eric Honoré. Autosomal-dominant polycystic kidney disease, the most frequent monogenic cause of kidney failure, is induced by mutations in the PKD1 or PKD2 genes, encoding polycystins TRPP1 and T.... (Source: Cell)
Source: Cell - October 30, 2009 Category: Cytology Source Type: journals
PI3 Kinase Signals BCR-Dependent Mature B Cell Survival
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Lakshmi Srinivasan, Yoshiteru Sasaki, Dinis Pedro Calado, Baochun Zhang, Ji Hye Paik, Ronald A. DePinho, Jeffrey L. Kutok, John F. Kearney, Kevin L. Otipoby, Klaus Rajewsky. Previous work has shown that mature B cells depend upon survival signals delivered to the cells by their antigen receptor (BCR). To identify the molecular nature of this survival signal, we have d.... (Source: Cell)
Source: Cell - October 30, 2009 Category: Cytology Source Type: journals
Regulation of MBK-2/DYRK by CDK-1 and the Pseudophosphatases EGG-4 and EGG-5 during the Oocyte-to-Embryo Transition
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Ken Chih-Chien Cheng, Richard Klancer, Andrew Singson, Geraldine Seydoux. DYRKs are kinases that self-activate in vitro by autophosphorylation of a YTY motif in the kinase domain, but their regulation in vivo is not well understood. In C. elegans zygotes, MBK-2/D.... (Source: Cell)
Source: Cell - October 30, 2009 Category: Cytology Source Type: journals
The Yeast Exosome Functions as a Macromolecular Cage to Channel RNA Substrates for Degradation
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Fabien Bonneau, Jérôme Basquin, Judith Ebert, Esben Lorentzen, Elena Conti. The exosome is a conserved macromolecular complex essential for RNA degradation. The nine-subunit core of the eukaryotic exosome shares a similar barrel-like architecture with prokaryotic complexe.... (Source: Cell)
Source: Cell - October 30, 2009 Category: Cytology Source Type: journals
β-Arrestin1 Regulates Zebrafish Hematopoiesis through Binding to YY1 and Relieving Polycomb Group Repression
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Rui Yue, Jiuhong Kang, Cong Zhao, Wenxiang Hu, Yawei Tang, Xiaosong Liu, Gang Pei. β-Arrestin1 is a multifunctional protein critically involved in signal transduction. Recently, it is also identified as a nuclear transcriptional regulator, but the underlying mechanisms and physi.... (Source: Cell)
Source: Cell - October 30, 2009 Category: Cytology Source Type: journals
Running in Reverse: The Structural Basis for Translocation Polarity in Hexameric Helicases
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Nathan D. Thomsen, James M. Berger. Hexameric helicases couple ATP hydrolysis to processive separation of nucleic acid duplexes, a process critical for gene expression, DNA replication, and repair. All hexameric helicases fall into .... (Source: Cell)
Source: Cell - October 30, 2009 Category: Cytology Source Type: journals
Tetherin Inhibits HIV-1 Release by Directly Tethering Virions to Cells
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David Perez-Caballero, Trinity Zang, Alaleh Ebrahimi, Matthew W. McNatt, Devon A. Gregory, Marc C. Johnson, Paul D. Bieniasz. Tetherin is an interferon-induced protein whose expression blocks the release of HIV-1 and other enveloped viral particles. The underlying mechanism by which tetherin functions and whether it dire.... (Source: Cell)
Source: Cell - October 30, 2009 Category: Cytology Source Type: journals
Serine/Threonine Phosphatases: Mechanism through Structure
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Yigong Shi. The reversible phosphorylation of proteins is accomplished by opposing activities of kinases and phosphatases. Relatively few protein serine/threonine phosphatases (PSPs) control the specific deph.... (Source: Cell)
Source: Cell - October 30, 2009 Category: Cytology Source Type: journals
Polycystins under Pressure
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Bernd Nilius. All cells detect mechanical signals, but the underlying molecular mechanisms are unclear. In this issue of Cell, Sharif-Naeini et al. (2009) show that a candidate mechanosensing channel, TR.... (Source: Cell)
Source: Cell - October 30, 2009 Category: Cytology Source Type: journals
Pseudophosphatases: Grab and Hold on
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Nicholas K. Tonks. Catalytically inactive pseudophosphatases are able to signal in the absence of enzymatic activity. Analyzing the oocyte-to-zygote transition in the worm, Cheng et al. (2009) and Parry et al. (2009.... (Source: Cell)
Source: Cell - October 30, 2009 Category: Cytology Source Type: journals
MAP-ping Unconventional Protein-DNA Interactions
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Elhadji M. Dioum, Eric M. Wauson, Melanie H. Cobb. Control of gene expression depends on a myriad of protein-DNA interactions, and the number of proteins involved just got larger. In this issue, Hu et al. (2009) identify hundreds of human proteins.... (Source: Cell)
Source: Cell - October 30, 2009 Category: Cytology Source Type: journals
Quiet Gene Circuit More Fragile Than Its Noisy Peer
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Tobias Bollenbach, Roy Kishony. Why is a particular architecture for a pathway chosen over seemingly equivalent alternatives? Çağatay et al. (2009) use a synthetic biology approach to show that fluctuations—or noise—in protein l.... (Source: Cell)
Source: Cell - October 30, 2009 Category: Cytology Source Type: journals
How to Drive Your Helicase in a Straight Line
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Anna Marie Pyle. Helicases are molecular motors that move along and remodel DNA, RNA, and associated protein complexes. Helicases are often directional. By analyzing crystal structures in complexes with RNA and AT.... (Source: Cell)
Source: Cell - October 30, 2009 Category: Cytology Source Type: journals
Tetherin Is as Tetherin Does
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Jason Hammonds, Paul Spearman. Tetherin is a cellular restriction factor that inhibits the release of HIV and other enveloped viruses from host cells. A paper from Perez-Caballero et al. (2009) in this issue of Cell clar.... (Source: Cell)
Source: Cell - October 30, 2009 Category: Cytology Source Type: journals
The Evolution Ringmaster
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Hopi E. Hoekstra. (Source: Cell)
Source: Cell - October 30, 2009 Category: Cytology Source Type: journals
Should You Be Tweeting?
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Laura Bonetta. Twitter needs no introduction. This “microblogging” service has gained tremendous popularity in the 2 years since its launch. Yet, most scientists are steering clear of it. Laura Bonetta speaks to.... (Source: Cell)
Source: Cell - October 30, 2009 Category: Cytology Source Type: journals
Swine Flu Vaccines: Reaching the Finish Line
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Justine Davies. The emergence of a swine influenza virus (H1N1) pandemic strain earlier this year prompted a huge worldwide effort to produce swine flu vaccines in time for the winter flu season. Justine Davies r.... (Source: Cell)
Source: Cell - October 30, 2009 Category: Cytology Source Type: journals
Evolutionary Biology Select
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Next to natural selection, sexual selection is the most powerful force driving evolution. A cluster of recent papers about sex and evolution are the focus of this Select. New work suggests that th.... (Source: Cell)
Source: Cell - October 30, 2009 Category: Cytology Source Type: journals
In This Issue
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(Source: Cell)
Source: Cell - October 30, 2009 Category: Cytology Source Type: journals
