The histone deacetylase inhibitor panobinostat exerts anticancer effects on esophageal squamous cell carcinoma cells by inducing cell cycle arrest
In this study, HDACIs were initially considered to have anticancer activity for ESCC, due to the high expression of HDAC genes in ESCC cell lines by analysing expression data of 27 ESCC cell lines from the Broad ‐Novartis Cancer Cell Line Encyclopedia. Next, we used five ESCC cell lines and one normal immortalized esophageal epithelial cell line to screen three HDACIs, panobinostat (LBH589), vorinostat (SAHA), and trichostatin A (TSA), for the ability to inhibit growth. Here, we report that LBH589 more ef fectively suppressed cell proliferation of ESCC cell lines, in a dose‐dependent manner, than TSA and SAHA, as well ...
Source: Cell Biochemistry and Function - November 28, 2018 Category: Biochemistry Authors: Yin ‐Wei Cheng, Lian‐Di Liao, Qian Yang, Yang Chen, Ping‐Juan Nie, Xiao‐Jun Zhang, Jian‐Jun Xie, Bao‐En Shan, Lian‐Mei Zhao, Li‐Yan Xu, En‐Min Li Tags: RESEARCH ARTICLE Source Type: research

Comparison of rheumatoid arthritis (RA) and osteoarthritis (OA) based on microarray profiles of human joint fibroblast ‐like synoviocytes
This study revealed the similar and different mechanisms of FLSs and different biomarkers that might with important regulatory effects on RA and OA. In OA, FLSs played an inflammatory role through TNF signalling pathway, targeting SELE, SERPINE1, and NFKBIA. Although TNF signalling pathway was also involved in the synovitis of RA, chemokine signalling pathway was a crucial pathway in mediating FLSs migration, invasion, and release of chemotaxis. CCR5, CCR7, CXCR4, CCL5, and CCR4 might be keys genes in RA. We expect that our results will bring more comprehensively understanding between RA and OA for researchers. (Source: Ce...
Source: Cell Biochemistry and Function - November 23, 2018 Category: Biochemistry Authors: Peian Cai, Tongmeng Jiang, Bo Li, Xiong Qin, Zhenhui Lu, Yiguan Le, Chong Shen, Yifeng Yang, Li Zheng, Jinmin Zhao Tags: RESEARCH ARTICLE Source Type: research

Role of estradiol and testosterone in Ucp1 expression in brown/beige adipocytes
Activity of brown/beige adipocytes is higher in women than in men. The expression level of uncoupling protein 1 (UCP1) is largely consistent with the thermogenic activity in brown/beige adipocytes. The present study examined the direct effects of sex hormones onUcp1 expression in brown adipocytes and beige adipocytes, which were differentiated from HB2 brown preadipocytes and 3T3 ‐L1 white preadipocytes, respectively; treatment with estradiol or testosterone was used during the early (days 0‐8) or late stage (days 8‐12) of brown adipogenesis and beige adipogenesis. On day 8 or day 12, cells were treated with or witho...
Source: Cell Biochemistry and Function - November 8, 2018 Category: Biochemistry Authors: Mika Suzuki, Masaru Murakami, Mitsuyuki Shirai, Osamu Hashimoto, Teruo Kawada, Tohru Matsui, Masayuki Funaba Tags: RESEARCH ARTICLE Source Type: research

LRRK2 impairs autophagy by mediating phosphorylation of leucyl ‐tRNA synthetase
In this study, we elucidated that leucyl‐tRNA synthetase (LRS) was an LRRK2 kinase substrate and identified T293 as an LRRK 2 phosphorylation site. LRRK2‐meidated LRS phosphorylation or G2019S can lead to impairment of LRS editing, increased ER stress, and accumulation of autophagy markers. These results demonstrate that LRRK2 kinase activity can facilitate accumulation of misfolded protein, suggesting that LRRK2 kinas e might be a potential PD therapeutic target along with previous studies. (Source: Cell Biochemistry and Function)
Source: Cell Biochemistry and Function - November 8, 2018 Category: Biochemistry Authors: Dong Hwan Ho, Hyejung Kim, Daleum Nam, Hyuna Sim, Janghwan Kim, Hyung Gun Kim, Ilhong Son, Wongi Seol Tags: RESEARCH ARTICLE Source Type: research

Effects of anoxic exposure on the nuclear factor of activated T cell (NFAT) transcription factors in the stress ‐tolerant wood frog
The wood frog,Lithobates sylvaticus (also known asRana sylvatica), is used for studying natural freeze tolerance. These animals convert 65% to 70% of their total body water into extracellular ice and survive freezing for weeks in winter. Freezing interrupts oxygen delivery to organs; thus, wood frogs limit their ATP usage by depressing their metabolism and redirecting the available energy only to prosurvival processes. Here, we studied the nuclear factor of activated T cell (NFAT) transcription factor family in response to 24 ‐hour anoxia, and 4‐hour aerobic recovery in liver and skeletal muscle. Protein expression lev...
Source: Cell Biochemistry and Function - November 8, 2018 Category: Biochemistry Authors: Rasha Al ‐Attar, Kenneth B. Storey Tags: RESEARCH ARTICLE Source Type: research

NAIF1 suppresses osteosarcoma progression and is regulated by miR ‐128
In this study, we demonstrated the downregulation of NAIF1 expression in both osteosarcoma tissues and cell lines. We nex t explored the potential role of NAIF1 in osteosarcoma cell proliferation and migration. The result showed that overexpression of NAIF1 evidently suppressed the cell proliferation and invasion of osteosarcoma. Furthermore, we investigated the potential mechanisms accounting for dysregulation of NAIF 1 in osteosarcoma. The bioinformatic prediction and luciferase reporter assay revealed that miR‐128 is a direct upstream regulator of NAIF1 and regulates NAIF1 expression by binding the 3′‐UTR of NAIF1...
Source: Cell Biochemistry and Function - November 8, 2018 Category: Biochemistry Authors: Daliang Kong, Zhe Zhang Tags: RESEARCH ARTICLE Source Type: research

SIX1 is upregulated in gastric cancer and regulates proliferation and invasion by targeting the ERK pathway and promoting epithelial ‐mesenchymal transition
Cell Biochemistry and Function, EarlyView. (Source: Cell Biochemistry and Function)
Source: Cell Biochemistry and Function - October 31, 2018 Category: Biochemistry Authors: Ying Xie, Peng Jin, Xuren Sun, Taiwei Jiao, Yining Zhang, Yue Li, Mingjun Sun Source Type: research

Issue Information
Cell Biochemistry and Function,Volume 36, Issue 7, Page 343-345, October 2018. (Source: Cell Biochemistry and Function)
Source: Cell Biochemistry and Function - October 16, 2018 Category: Biochemistry Source Type: research

Tumorigenic PVT ‐1 gene locus is governed by miR‐2909 RNomics
Cell Biochemistry and Function, EarlyView. (Source: Cell Biochemistry and Function)
Source: Cell Biochemistry and Function - October 15, 2018 Category: Biochemistry Authors: Sameena Wani, Deepak Kaul Source Type: research

Two weeks of high ‐fat feeding disturb lipid and cholesterol molecular markers
Cell Biochemistry and Function, EarlyView. (Source: Cell Biochemistry and Function)
Source: Cell Biochemistry and Function - October 4, 2018 Category: Biochemistry Authors: L. Magri ‐Tomaz, L. Melbouci, J. Mercier, Ya Ou, N. Auclair, F. S. Lira, J‐M. Lavoie, D. H. St‐Pierre Source Type: research

Suppression of ABCD2 dysregulates lipid metabolism via dysregulation of miR ‐141:ACSL4 in human osteoarthritis
Cell Biochemistry and Function, EarlyView. (Source: Cell Biochemistry and Function)
Source: Cell Biochemistry and Function - September 28, 2018 Category: Biochemistry Authors: Sujeong Park, Jinjoo Oh, Yong ‐Il Kim, Seong‐Kyu Choe, Churl‐Hong Chun, Eun‐Jung Jin Source Type: research

HIV ‐1 Tat‐induced bystander apoptosis in Jurkat cells involves unfolded protein responses
Cell Biochemistry and Function, EarlyView. (Source: Cell Biochemistry and Function)
Source: Cell Biochemistry and Function - September 24, 2018 Category: Biochemistry Authors: J éssica Campestrini, Douglas Bardini Silveira, Aguinaldo Roberto Pinto Source Type: research

HMGB3 promotes the proliferation and metastasis of glioblastoma and is negatively regulated by miR ‐200b‐3p and miR‐200c‐3p
Cell Biochemistry and Function, EarlyView. (Source: Cell Biochemistry and Function)
Source: Cell Biochemistry and Function - September 20, 2018 Category: Biochemistry Authors: JianxunLiu , LilingWang , XuesongLi Source Type: research

Issue Information
Cell Biochemistry and Function,Volume 36, Issue 6, Page 289-291, August 2018. (Source: Cell Biochemistry and Function)
Source: Cell Biochemistry and Function - August 9, 2018 Category: Biochemistry Source Type: research

High glucose condition limited the angiogenic/cardiogenic capacity of murine cardiac progenitor cells in in vitro and in vivo milieu
Cell Biochemistry and Function, EarlyView. (Source: Cell Biochemistry and Function)
Source: Cell Biochemistry and Function - July 27, 2018 Category: Biochemistry Authors: MajidKhaksar , MansourSayyari , JafarRezaie , AydaPouyafar , SoheilaMontazersaheb , RezaRahbarghazi Source Type: research