MSC-derived mitochondria promote axonal regeneration via Atf3 gene up-regulation by ROS induced DNA double strand breaks at transcription initiation region
The repair of peripheral nerve injury poses a clinical challenge, necessitating further investigation into novel therapeutic approaches. In recent years, bone marrow mesenchymal stromal cell (MSC)-derived mito... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - April 25, 2024 Category: Molecular Biology Authors: Yingchi Zhang, Tao Xu, Jie Xie, Hua Wu, Weihua Hu and Xuefeng Yuan Tags: Research Source Type: research
Endothelial cell dynamics in sepsis-induced acute lung injury and acute respiratory distress syndrome: pathogenesis and therapeutic implications
Sepsis, a prevalent critical condition in clinics, continues to be the leading cause of death from infections and a global healthcare issue. Among the organs susceptible to the harmful effects of sepsis, the l... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - April 25, 2024 Category: Molecular Biology Authors: Xinyu Qiao, Junhao Yin, Zhihuan Zheng, Liangge Li and Xiujing Feng Tags: Review Source Type: research
Therapeutic bacteria and viruses to combat cancer: double-edged sword in cancer therapy: new insights for future
Cancer, ranked as the second leading cause of mortality worldwide, leads to the death of approximately seven million people annually, establishing itself as one of the most significant health challenges global... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - April 24, 2024 Category: Molecular Biology Authors: Aref Yarahmadi, Mitra Zare, Masoomeh Aghayari, Hamed Afkhami and Gholam Ali Jafari Tags: Review Source Type: research
Neem leaf glycoprotein binding to Dectin-1 receptors on dendritic cell induces type-1 immunity through CARD9 mediated intracellular signal to NF κB
A water-soluble ingredient of mature leaves of the tropical mahogany ‘Neem’ (Azadirachta indica), was identified as glycoprotein, thus being named as ‘Neem Leaf Glycoprotein’ (NLGP). This non-toxic leaf-component... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - April 23, 2024 Category: Molecular Biology Authors: Nilanjan Ganguly, Tapasi Das, Avishek Bhuniya, Ipsita Guha, Mohona Chakravarti, Sukanya Dhar, Anirban Sarkar, Saurav Bera, Jesmita Dhar, Shayani Dasgupta, Akata Saha, Tithi Ghosh, Juhina Das, Ugir Hossain Sk, Saptak Banerjee, Subrata Laskar & hellip; Tags: Research Source Type: research
A promising frontier: targeting NETs for stroke treatment breakthroughs
Stroke is a prevalent global acute cerebrovascular condition, with ischaemic stroke being the most frequently occurring type. After a stroke, neutrophils accumulate in the brain and subsequently generate and r... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - April 23, 2024 Category: Molecular Biology Authors: Huijie Fang, Yunfei Bo, Zhongfei Hao, Ge Mang, Jiaqi Jin and Hongjun Wang Tags: Review Source Type: research
Interleukin-4 protects retinal ganglion cells and promotes axon regeneration
The preservation of retinal ganglion cells (RGCs) and the facilitation of axon regeneration are crucial considerations in the management of various vision-threatening disorders. Therefore, we investigate the e... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - April 22, 2024 Category: Molecular Biology Authors: Zhaoyang Zuo, Bin Fan, Ziyuan Zhang, Yang Liang, Jing Chi and Guangyu Li Tags: Research Source Type: research
High glucose-induced p66Shc mitochondrial translocation regulates autophagy initiation and autophagosome formation in syncytiotrophoblast and extravillous trophoblast
p66Shc, as a redox enzyme, regulates reactive oxygen species (ROS) production in mitochondria and autophagy. However, the mechanisms by which p66Shc affects autophagosome formation are not fully understood. (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - April 20, 2024 Category: Molecular Biology Authors: Lulu Ji, Xiaoli Zhang, Zhiguo Chen, Yuexiao Wang, Hengxuan Zhu, Yaru Nai, Yanyi Huang, Rujie Lai, Yu Zhong, Xiting Yang, Qiongtao Wang, Hanyang Hu and Lin Wang Tags: Research Source Type: research
GDF9His209GlnfsTer6/S428T and GDF9Q321X/S428T bi-allelic variants caused female subfertility with defective follicle enlargement
Antral follicles consist of an oocyte cumulus complex surrounding by somatic cells, including mural granulosa cells as the inner layer and theca cells as the outsider layer. The communications between oocytes ... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - April 20, 2024 Category: Molecular Biology Authors: Yuwei Duan, Bing Cai, Jing Guo, Chen Wang, Qingyun Mai, Yan Xu, Yang Zeng, Yue Shi, Boyan Wang, Chenhui Ding, Minghui Chen, Canquan Zhou and Yanwen Xu Tags: Research Source Type: research
Structural determinants for activation of the Tau kinase CDK5 by the serotonin receptor 5-HT7R
Multiple neurodegenerative diseases are induced by the formation and deposition of protein aggregates. In particular, the microtubule-associated protein Tau leads to the development of so-called tauopathies ch... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - April 19, 2024 Category: Molecular Biology Authors: Jana Ackmann, Alina Br üge, Lizaveta Gotina, Sungsu Lim, Kathrin Jahreis, Anna-Lena Vollbrecht, Yun Kyung Kim, Ae Nim Pae, Josephine Labus and Evgeni Ponimaskin Tags: Research Source Type: research
Exploring the role of Prx II in mitigating endoplasmic reticulum stress and mitochondrial dysfunction in neurodegeneration
Neurodegenerative diseases are increasingly recognized for their association with oxidative stress, which leads to progressive dysfunction and loss of neurons, manifesting in cognitive and motor impairments. T... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - April 18, 2024 Category: Molecular Biology Authors: Mei-Hua Jin, Lin Feng, Hong-Yi Xiang, Hu-Nan Sun, Ying-Hao Han and Taeho Kwon Tags: Research Source Type: research
Role of imbalanced gut microbiota in promoting CRC metastasis: from theory to clinical application
Metastasis poses a major challenge in colorectal cancer (CRC) treatment and remains a primary cause of mortality among patients with CRC. Recent investigations have elucidated the involvement of disrupted gut ... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - April 18, 2024 Category: Molecular Biology Authors: Shiying Fan, Lujia Zhou, Wenjie Zhang, Daorong Wang and Dong Tang Tags: Review Source Type: research
Wnt signaling regulates chemokine production and cell migration of circulating human monocytes
The β-catenin dependent canonical Wnt signaling pathway plays a crucial role in maintaining normal homeostasis. However, when dysregulated, Wnt signaling is closely associated with various pathological conditi... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - April 16, 2024 Category: Molecular Biology Authors: Natalie Zelikson, Shaina Ben, Michal Caspi, Raneen Tarabe, Yonatan Shaleve, Yael Pri-Paz Basson, Oshrat Tayer-Shifman, Elad Goldberg, Shaye Kivity and Rina Rosin-Arbesfeld Tags: Research Source Type: research
Increased levels of villus-derived exosomal miR-29a-3p in normal pregnancy than uRPL patients suppresses decidual NK cell production of interferon- γ and exerts a therapeutic effect in abortion-prone mice
Recurrent pregnancy loss (RPL) patients have higher absolute numbers of decidual natural killer (dNK) cells with elevated intracellular IFN- γ levels leading to a pro-inflammatory cytokine milieu, which contrib... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - April 16, 2024 Category: Molecular Biology Authors: Zheng Fang, Jiaqin Mao, Jialyu Huang, Huijun Sun, Xueyan Lu, Hui Lei, Jie Dong, Shuqiang Chen and Xiaohong Wang Tags: Research Source Type: research
Potentials and future perspectives of multi-target drugs in cancer treatment: the next generation anti-cancer agents
Cancer is a major public health problem worldwide with more than an estimated 19.3 million new cases in 2020. The occurrence rises dramatically with age, and the overall risk accumulation is combined with the ... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - April 15, 2024 Category: Molecular Biology Authors: Ali Doostmohammadi, Hossein Jooya, Kimia Ghorbanian, Sargol Gohari and Mehdi Dadashpour Tags: Review Source Type: research
RUNX1-BMP2 promotes vasculogenic mimicry in laryngeal squamous cell carcinoma via activation of the PI3K-AKT signaling pathway
Laryngeal squamous cell carcinoma (LSCC) is one of the most common malignant tumors of the head and neck. Vasculogenic mimicry (VM) is crucial for tumor growth and metastasis and refers to the formation of flu... (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - April 12, 2024 Category: Molecular Biology Authors: Qingwen Zhu, Xinyu Zhang, Fei Lu, Siyu Miao, Chunyang Zhang, Zhenzhen Liu, Zejun Gao, Meihao Qi, Xiaogang An, Panling Geng, Sufang Wang, Hongbo Ren, Fugen Han, Ruyue Zhang and DingJun Zha Tags: Research Source Type: research
