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Novel inhibitors of the calcineurin/NFATc hub - alternatives to CsA and FK506?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The drugs cyclosporine A (CsA) and tacrolimus (FK506) revolutionized organ transplantation. Both compounds are still widely used in the clinic as well as for basic research, even though they have dramatic side effects and modulate other pathways than calcineurin-NFATc, too. To answer the major open question - whether the adverse side effects are secondary to the actions of the drugs on the calcineurin-NFAT pathway - alternative inhibitors were developed. Ideal inhibitors should discriminate between the inhibition of (i) calcineurin and peptidyl-prolyl cis-trans isomerases (PPIases; the matchmaker proteins of CsA and FK506)...
Source: Cell Communication and Signaling - October 27, 2009 Category: Molecular Biology Authors: Matthias SieberRia Baumgrass Source Type: journals

Eps15: a multifunctional adaptor protein regulating intracellular traffickingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Over expression of receptor tyrosine kinases is responsible for the development of a wide variety of malignancies. Termination of growth factor signaling is primarily determined by the down regulation of active growth factor/receptor complexes. In recent years, considerable insight has been gained in the endocytosis and degradation of growth factor receptors. A crucial player in this process is the EGFR Protein tyrosine kinase Substrate #15, or Eps15. This protein functions as a scaffolding adaptor protein and is involved both in secretion and endocytosis. Eps15 has been shown to bind to AP-1 and AP-2 complexes, to bind to...
Source: Cell Communication and Signaling - October 7, 2009 Category: Molecular Biology Authors: Paul Van Bergen en Henegouwen Source Type: journals

Function, regulation and pathological roles of the Gab/DOS docking proteinsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Since their discovery a little more than a decade ago, the docking proteins of the Gab/DOS family have emerged as important signalling elements in metazoans. Gab/DOS proteins integrate and amplify signals from a wide variety of sources including growth factor, cytokine and antigen receptors as well as cell adhesion molecules. They also contribute to signal diversification by channelling the information from activated receptors into signalling pathways with distinct biological functions. Recent approaches in protein biochemistry and systems biology have revealed that Gab proteins are subject to complex regulation by feed-fo...
Source: Cell Communication and Signaling - September 7, 2009 Category: Molecular Biology Authors: Franziska WoehrleRoger DalyTilman Brummer Source Type: journals

Rac1 activation inhibits E-cadherin-mediated adherens junctions via binding to IQGAP1 in pancreatic carcinoma cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These results indicate that active Rac1 destabilises E-cadherin-mediated cell-cell adhesion in pancreatic carcinoma cells by interacting with IQGAP1 which is associated with a disassembly of E-cadherin-mediated adherens junctions. Inhibition of Rac1 activity induced increased E-cadherin-mediated cellular adhesion. (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - September 7, 2009 Category: Molecular Biology Authors: Beatrix HageKatrin MeinelIris BaumKlaudia GiehlAndre Menke Source Type: journals

Plasma membrane rafts engaged in T cell signalling: new developments in an old conceptEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Considerable controversy arose over the concept that cholesterol/sphingolipid-rich rafts in the T cell plasma membrane serve as a platform for TCR signalling reactions. This controversy was founded on the initial definition of rafts as detergent resistant membranes which later turned out to misrepresent many features of cell membrane organisation under physiological conditions. Raft-organisation was subsequently studied using a number of detergent-free experimental approaches. The results led to a refined perception of membrane rafts which resolves the controversies. Here we review new biophysical and biochemical data whic...
Source: Cell Communication and Signaling - September 3, 2009 Category: Molecular Biology Authors: Thomas HarderDhaval Sangani Source Type: journals

Cholinergic receptor pathways involved in apoptosis, cell proliferation and neuronal differentiationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Acetylcholine (ACh) has been shown to modulate neuronal differentiation during early development. Both muscarinic and nicotinic acetylcholine receptors (AChRs) regulate a wide variety of physiological responses, including apoptosis, cellular proliferation and neuronal differentiation. However, the intracellular mechanisms underlying these effects of AChR signaling are not fully understood. It is known that activation of AChRs increase cellular proliferation and neurogenesis and that regulation of intracellular calcium through AChRs may underlie the many functions of ACh. Intriguingly, activation of diverse signaling molecu...
Source: Cell Communication and Signaling - August 26, 2009 Category: Molecular Biology Authors: Rodrigo ResendeAvishek Adhikari Source Type: journals

Tumor biology and cancer therapy - an evolving relationshipEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of palliative chemotherapy is to increase survival whilst maintaining maximum quality of life for the individual concerned. Although we are still continuing to explore the optimum use of traditional chemotherapy agents the introduction of targeted therapies has significantly broadened the therapeutic options. Interestingly, the results from current trials put the underlying biological concept often into a new, less favorable perspective. Recent data suggested that altered pathways underlie cancer rather than altered genes. Thus, any effective therapeutic agent will have to target downstream parts or physiological e...
Source: Cell Communication and Signaling - August 12, 2009 Category: Molecular Biology Authors: Thomas SeufferleinJohann AhnDenis KrndijaUlrike LotherGuido AdlerGoetz von Wichert Source Type: journals

Regulation of MicroRNA Biogenesis: A miRiad of mechanismsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
microRNAs are small, non-coding RNAs that influence diverse biological functions through the repression of target genes during normal development and pathological responses. Widespread use of microRNA arrays to profile microRNA expression has indicated that the levels of many microRNAs are altered during development and disease. These findings have prompted a great deal of investigation into the mechanism and function of microRNA-mediated repression. However, the mechanisms which govern the regulation of microRNA biogenesis and activity are just beginning to be uncovered. Following transcription, mature microRNA are genera...
Source: Cell Communication and Signaling - August 9, 2009 Category: Molecular Biology Authors: Brandi DavisAkiko Hata Source Type: journals

HSP90 is essential for Jak-STAT signaling in classical Hodgkin Lymphoma cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In classical Hodgkin lymphoma (cHL) chemotherapeutic regimens are associated with stagnant rates of secondary malignancies requiring the development of new therapeutic strategies. We and others have shown that permanently activated Signal Transducer and Activator of Transcription (STAT) molecules are essential for cHL cells. Recently an overexpression of heat-shock protein 90 (HSP90) in cHL cells has been shown and inhibition of HSP90 seems to affect cHL cell survival. Here we analysed the effects of HSP90 inhibition by geldanamycin derivative 17-AAG or RNA interference (RNAi) to aberrant Jak-STAT signaling in cHL cells. T...
Source: Cell Communication and Signaling - July 15, 2009 Category: Molecular Biology Authors: Nils SchoofFrederike von BoninLorenz TrumperDieter Kube Source Type: journals

Illuminating the life of GPCRsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The investigation of biological systems highly depends on the possibilities that allow scientists to visualize and quantify biomolecules and their related activities in real-time and non-invasively. G-protein coupled receptors represent a family of very dynamic and highly regulated transmembrane proteins that are involved in various important physiological processes. Since their localization is not confined to the cell surface they have been a very attractive "moving target" and the understanding of their intracellular pathways as well as the identified protein-protein-interactions has had implications for therapeutic inte...
Source: Cell Communication and Signaling - July 13, 2009 Category: Molecular Biology Authors: Ilka BohmeAnnette Beck-Sickinger Source Type: journals

Activin signaling as an emerging target for therapeutic interventionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
After the initial discovery of activins as important regulators of reproduction, novel and diverse roles have been unraveled for them. Activins are expressed in various tissues and have a broad range of activities including the regulation of gonadal function, hormonal homeostasis, growth and differentiation of musculoskeletal tissues, regulation of growth and metastasis of cancer cells, proliferation and differentiation of embryonic stem cells, and even higher brain functions. Activins signal through a combination of type I and II transmembrane serine/threonine kinase receptors. Activin receptors are shared by multiple tra...
Source: Cell Communication and Signaling - June 17, 2009 Category: Molecular Biology Authors: Kunihiro TsuchidaMasashi NakataniKeisuke HitachiAkiyoshi UezumiYoshihide SunadaHiroshi AgetaKaoru Inokuchi Source Type: journals

Expression and function of the insulin receptor substrate proteins in cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Insulin Receptor Substrate (IRS) proteins are cytoplasmic adaptor proteins that function as essential signaling intermediates downstream of activated cell surface receptors, many of which have been implicated in cancer. The IRS proteins do not contain any intrinsic kinase activity, but rather serve as scaffolds to organize signaling complexes and initiate intracellular signaling pathways. As common intermediates of multiple receptors that can influence tumor progression, the IRS proteins are positioned to play a pivotal role in regulating the response of tumor cells to many different microenvironmental stimuli. Limited...
Source: Cell Communication and Signaling - June 16, 2009 Category: Molecular Biology Authors: Katerina MardilovichShannon PankratzLeslie Shaw Source Type: journals

Crk and CrkL adaptor proteins: networks for physiological and pathological signalingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Crk adaptor proteins (Crk and Crk-L) constitute an integral part of a network of essential signal transductional pathways in human and other organisms that act as major convergence points in tyrosine kinase signaling. Crk proteins integrate signals from a wide variety of sources, including growth factors, extracellular matrix molecules, bacterial pathogens, and apoptotic cells. Mounting evidence indicates that dysregulation of Crk proteins is associated with human diseases, including cancer and susceptibility to pathogen infections. Recent structural work has identified new and unusual insights into the regulation of...
Source: Cell Communication and Signaling - May 10, 2009 Category: Molecular Biology Authors: Raymond B Birge, Charalampos Kalodimos, Fuyuhiko Inagaki and Shinya Tanaka Source Type: journals

The receptor RAGE: Bridging inflammation and cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The receptor for advanced glycation end products (RAGE) is a single transmembrane receptor of the immunoglobulin superfamily that is mainly expressed on immune cells, neurons, activated endothelial and vascular smooth muscle cells, bone forming cells, and a variety of cancer cells. RAGE is a multifunctional receptor that binds a broad repertoire of ligands and mediates responses to cell damage and stress conditions. It activates programs responsible for acute and chronic inflammation, and is implicated in a number of pathological diseases, including diabetic complications, stroke, atheriosclerosis, arthritis, and neurodege...
Source: Cell Communication and Signaling - May 8, 2009 Category: Molecular Biology Authors: Astrid Riehl, Julia Nemeth, Peter Angel and Jochen Hess Source Type: journals

Distinct phosphorylation requirements regulate cortactin activation by TirEPEC and its binding to N-WASP.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We propose that cortactin binds Tir through its N-terminal part in a tyrosine and serine phosphorylation independent manner while SH3 domain binding and activation of N-WASP is regulated by tyrosine and serine mediated phosphorylation of cortactin. Therefore cortactin could act on Tir-Nck-N-WASP pathway and control a possible cycling activity of N-WASP underlying pedestal formation. (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - May 6, 2009 Category: Molecular Biology Authors: Elvira Nieto-Pelegrin and Narcisa Martinez-Quiles Source Type: journals

The roles of ASK family proteins in stress responses and diseasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Apoptosis signal-regulating kinase 1 (ASK1) is a member of the mitogen-activated protein kinase kinase kinase family, which activates c-Jun N-terminal kinase and p38 in response to a diverse array of stresses such as oxidative stress, endoplasmic reticulum stress and calcium influx. In the past decade, various regulatory mechanisms of ASK1 have been elucidated, including its oxidative stress-dependent activation. Recently, it has emerged that ASK family proteins play key roles in cancer, cardiovascular diseases and neurodegenerative diseases. In this review, we summarize the recent findings on ASK family proteins and their...
Source: Cell Communication and Signaling - April 24, 2009 Category: Molecular Biology Authors: Kazuki Hattori, Isao Naguro, Christopher Runchel and Hidenori Ichijo Source Type: journals

Regulation of cellular proliferation, differentiation and cell death by activated RafEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The protein kinases Raf-1, A-Raf and B-Raf connect receptor stimulation with intracellular signaling pathways and function as a central intermediate in many signaling pathways. Gain-of-function experiments shed light on the pleiotropic biological activities of these enzymes. Expression experiments involving constitutively active Raf revealed the essential functions of Raf in controlling proliferation, differentiation and cell death in a cell-type specific manner. (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - April 21, 2009 Category: Molecular Biology Authors: Gerald Thiel, Myriam Ekici and Oliver G Rossler Source Type: journals

Connexins: a myriad of functions extending beyond assembly of gap junction channelsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Connexins constitute a large family of trans-membrane proteins that allow intercellular communication and the transfer of ions and small signaling molecules between cells. Recent studies have revealed complex translational and post-translational mechanisms that regulate connexin synthesis, maturation, membrane transport and degradation that in turn modulate gap junction intercellular communication. With the growing myriad of connexin interacting proteins, including cytoskeletal elements, junctional proteins, and enzymes, gap junctions are now perceived, not only as channels between neighboring cells, but as signaling compl...
Source: Cell Communication and Signaling - March 12, 2009 Category: Molecular Biology Authors: Hashem A Dbouk, Rana M Mroue, Marwan E El-Sabban and Rabih S Talhouk Source Type: journals

Expression of excess receptors and negative feedback control of signal pathways are required for rapid activation and prompt cessation of signal transductionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The present kinetic analysis revealed that excess receptors and negative feedback regulation promote activation and cessation of signal transduction with a low amount of extracellular ligand. (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - March 3, 2009 Category: Molecular Biology Authors: Hiroshi Kobayashi, Ryuzo Azuma and Takuo Yasunaga Source Type: journals

Posttranslational regulation of Fas ligand functionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The TNF superfamily member Fas ligand acts as a prototypic death factor. Due to its ability to induce apoptosis in Fas (APO-1, CD95) expressing cells, Fas ligand participates in essential effector functions of the immune system. It is involved in natural killer cell- and T cell-mediated cytotoxicity, the establishment of immune privilege, and in termination of immune responses by induction of activation-induced cell death. In addition, Fas ligand-positive tumours may evade immune surveillance by killing Fas-positive tumour-infiltrating cells. Given these strong cytotoxic capabilities of Fas ligand, it is obvious that its f...
Source: Cell Communication and Signaling - December 29, 2008 Category: Molecular Biology Authors: Matthias Voss, Marcus Lettau, Maren Paulsen and Ottmar Janssen Source Type: journals

Extravasation of leukocytes in comparison to tumor cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The multi-step process of the emigration of cells from the blood stream through the vascular endothelium into the tissue has been termed extravasation. The extravasation of leukocytes is fairly well characterized down to the molecular level, and has been reviewed in several aspects. Comparatively little is known about the extravasation of tumor cells, which is part of the hematogenic metastasis formation. Although the steps of the process are basically the same in leukocytes and tumor cells, i.e. rolling, adhesion, transmigration (diapedesis), the molecules that are involved are different. A further important difference is...
Source: Cell Communication and Signaling - December 4, 2008 Category: Molecular Biology Authors: Carina Strell and Frank Entschladen Source Type: journals

Gamma-secretase inhibition combined with platinum compounds enhances cell death in a large subset of colorectal cancer cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We conclude that gamma-secretase inhibition results in activation of the MAP kinases Erk1/2 and, when used in conjunction, enhances cell death induced by platinum compounds in a large subset of colorectal cancer cell lines. Furthermore the activation of Erk appears to be of particular importance in mediating the enhanced effect seen, as its inhibition abrogates the observed phenomenon. These findings do not only highlight the importance of signalling pathway crosstalk but they may also suggest a new avenue of combination therapy for some colorectal cancers. (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - October 24, 2008 Category: Molecular Biology Authors: Tamara Aleksic and Stephan M Feller Source Type: journals

The small GTPase RhoH is an atypical regulator of haematopoietic cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Rho GTPases are a distinct subfamily of the superfamily of Ras GTPases. The best-characterised members are RhoA, Rac and Cdc42 that regulate many diverse actions such as actin cytoskeleton reorganisation, adhesion, motility as well as cell proliferation, differentiation and gene transcription. Among the 20 members of that family, only Rac2 and RhoH show an expression restricted to the haematopoietic lineage. RhoH was first discovered in 1995 as a fusion transcript with the transcriptional repressor LAZ3/BCL6. It was therefore initially named translation three four (TTF) but later on renamed RhoH due to its close relations...
Source: Cell Communication and Signaling - September 29, 2008 Category: Molecular Biology Authors: Florian Fueller and Katharina F Kubatzky Source Type: journals

Signal transduction around thymic stromal lymphopoietin (TSLP) in atopic asthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Thymic stromal lymphopoietin (TSLP), a novel interleukin-7-like cytokine, triggers dendritic cell-mediated inflammatory responses ultimately executed by T helper cells of the Th2 subtype. TSLP emerged as a central player in the development of allergic symptoms, especially in the airways, and is a prime regulatory cytokine at the interface of virus- or antigen-exposed epithelial cells and dendritic cells (DCs). DCs activated by epithelium-derived TSLP can promote naïve CD4+ T cells to adopt a Th2 phenotype, which in turn recruite eosinophilic and basophilic granulocytes as well as mast cells into the airway mucosa. These d...
Source: Cell Communication and Signaling - August 25, 2008 Category: Molecular Biology Authors: Katrin Sebastian, Andreas Borowski, Michael Kuepper and Karlheinz Friedrich Source Type: journals

Signal transduction around thymic stromal lymphopoietin (TSLP) in atopic asthmaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Thymic stromal lymphopoietin (TSLP), a novel interleukin-7-like cytokine, triggers dendritic cell-mediated inflammatory responses ultimately executed by T helper cells of the Th2 subtype. TSLP emerged as a central player in the development of allergic symptoms, especially in the airways, and is a prime regulatory cytokine at the interface of virus- or antigen-exposed epithelial cells and dendritic cells (DCs). DCs activated by epithelium-derived TSLP can promote naive CD4+ T cells to adopt a Th2 phenotype, which in turn recruite eosinophilic and basophilic granulocytes as well as mast cells into the airway mucosa. These di...
Source: Cell Communication and Signaling - August 25, 2008 Category: Molecular Biology Authors: Katrin Sebastian, Andreas Borowski, Michael Kuepper and Karlheinz Friedrich Source Type: journals

Targeting focal adhesions:Helicobacter pylori-host communication in cell migrationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Highly dynamic integrin-based focal adhesions provide an important structural basis for anchoring the cellular actin cytoskeleton to the surrounding extracellular matrix. The human pathogen Helicobacter pylori (H. pylori) directly targets integrins with drastic consequences on the epithelial cell morphology and migration, which might contribute to the disruption of the gastric epithelium in vivo. In this review, we summarize the recent findings concerning the complex mechanism through which H. pylori interferes with host integrin signaling thereby deregulating focal adhesions and the actin cytoskeleton of motile epithelial...
Source: Cell Communication and Signaling - August 6, 2008 Category: Molecular Biology Authors: Sabine Schneider, Christiane Weydig and Silja Wessler Source Type: journals

RNA interference-mediated gene silencing in murine T cells: in vitro and in vivo validation of proinflammatory target genesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: T cells play a central role in many inflammatory diseases, hence the identification and validation of T cell-specific target genes will increase the understanding of T cell function in pathologic inflammatory situations. RNA interference (RNAi), with its ability to induce specific gene silencing in mammalian cells, represents a powerful technology to investigate and validate the function of pharmaceutical target genes in vitro and in vivo. The aim of the present study was to systematically explore RNAi-mediated gene-silencing of known T cell-specific model signaling molecules in primary murine T cells in vitro ...
Source: Cell Communication and Signaling - August 6, 2008 Category: Molecular Biology Authors: Tatjana C Gust, Luisa Neubrandt, Claudia Merz, Khusru Asadullah, Ulrich Zügel and Arne von Bonin Source Type: journals

New insight into CCN3 interactions - Nuclear CCN3 : fact or fantasy?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The identification of potential partners for CCN3(NOV) sheds new light on the biological activity of this signaling protein. In particular, the physical interaction of CCN3 with the IL33 cytokine combined with previous data indicating that CCN3 expression was regulated by TNFalpha and IL1 cytokines, point to CCN3 as a potent player in a variety of inflammatory responses, including neurodegenerative disease, and arthritis. Nuclear proteins that are involved in the regulation of RNA processing and chromatin remodeling were also found to interact with CCN3. These observations reinforce the concept that routing of CCN3 to the ...
Source: Cell Communication and Signaling - August 8, 2006 Category: Molecular Biology Authors: Bernard Perbal Source Type: journals

An active form of Vav1 induces migration of mammary epithelial cells by stimulating secretion of an epidermal growth factor receptor ligandEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our results indicate that increased migration of active Vav1 expressing cells is dependent on Vav1 GEF activity and secretion of an EGF receptor ligand. In addition, activation of ERK downstream of Vav1 is dependent on autocrine EGF receptor stimulation while active Vav1 can stimulate Rac1 and PAK activation independent of ligand binding to the EGF receptor. Thus, stimulation of migration by activated Vav1 involves both EGF receptor-dependent and independent activities induced through the Rho GEF domain of Vav1. (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - May 18, 2006 Category: Molecular Biology Authors: Julie L Wilsbacher, Sheri L Moores and Joan S Brugge Source Type: journals

The placental cholinergic system: localization to the cytotrophoblast and modulation of nitric oxideEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These data demonstrate that placental ChAT localizes to the cytotrophoblast and some mesenchymal cells in human placenta. It further suggests that ACh acts via muscarinic receptors on the trophoblast cell membrane to modulate NO in an estrogen-dependent manner. (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - May 10, 2006 Category: Molecular Biology Authors: Md Badiul Bhuiyan, Ferid Murad and Michael E Fant Source Type: journals

NOV story: the way to CCN3Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The principal aim of this historical review- the first in a new series- is to present the basic concepts that led to the discovery of NOV and to show how our ideas evolved regarding the role and functions of this new class of proteins. It should prove particularly useful to the new comers and to students who are engaged in this exciting field. It is also a good opportunity to acknowledge the input of those who participated in the development of this scientific endeavour (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - February 20, 2006 Category: Molecular Biology Authors: Bernard Perbal Source Type: journals

Identification of mitogen-activated protein kinase docking sites in enzymes that metabolize phosphatidylinositols and inositol phosphatesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The results indicate that there may be extensive crosstalk between MAPK signaling and signaling pathways that are regulated by cellular levels of PIs or IPs. (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - January 30, 2006 Category: Molecular Biology Authors: Kevin K Caldwell, Marcos Sosa and Colin T Buckley Source Type: journals

Integration of Myeloblastosis Associated Virus proviral sequences occurs in the vicinity of genes encoding signaling proteins and regulators of cell proliferationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The identification of putative target genes for MAV provides important clues for the understanding of the MAV pathogenic potential. These studies identified ADAMTS1 as a gene upregulated in MAV-induced nephroblastoma and established that ccn3/nov is not a preferential site of integration for MAV as previously thought. The present results support our hypothesis that the highly efficient and specific MAV-induced tumorigenesis results from the alteration of multiple target genes in differentiating blastemal cells, some of which are required for the progression to highly aggressive stages. This study reinforces our...
Source: Cell Communication and Signaling - January 10, 2006 Category: Molecular Biology Authors: Chang Long Li, Philippe Coullin, Alain Bernheim, Véronique Joliot, Charles Auffray, Rima Zoroob and Bernard Perbal Source Type: journals

Activation of nuclear factor kappa B (NF-κB) by connective tissue growth factor (CCN2) is involved in sustaining the survival of primary rat hepatic stellate cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: CCN2 contributes to the survival of primary HSC through the NF-κB pathway. (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - November 22, 2005 Category: Molecular Biology Authors: Runping Gao and David R Brigstock Source Type: journals

Apical membrane P2Y4 purinergic receptor controls K+ secretion by strial marginal cell epitheliumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The results support the conclusion that regulation of K+ secretion across strial marginal cell epithelium occurs by P2Y4 receptors at the apical membrane. The apparent lack of desensitization of the response is consistent with two processes: a rapid-onset phosphorylation of KCNE1 channel subunit and a slower-onset of regulation by depletion of plasma membrane PIP2. (Source: Cell Communication and Signaling)
Source: Cell Communication and Signaling - November 2, 2005 Category: Molecular Biology Authors: Daniel C Marcus, Jianzhong Liu, Jun Ho Lee, Elias Q Scherer, Margaret A Scofield and Philine Wangemann Source Type: journals