The effects of pregnancy, its progression, and its cessation on human (maternal) biological aging
Cell Metab. 2024 Mar 19:S1550-4131(24)00079-2. doi: 10.1016/j.cmet.2024.02.016. Online ahead of print.NO ABSTRACTPMID:38521058 | DOI:10.1016/j.cmet.2024.02.016 (Source: Cell Metabolism)
Source: Cell Metabolism - March 23, 2024 Category: Cytology Authors: Hung Pham Tara Thompson-Felix Darina Czamara Jerod M Rasmussen Adam Lombroso Sonja Entringer Elisabeth B Binder Pathik D Wadhwa Claudia Buss Kieran J O'Donnell Source Type: research

The effects of pregnancy, its progression, and its cessation on human (maternal) biological aging
Cell Metab. 2024 Mar 19:S1550-4131(24)00079-2. doi: 10.1016/j.cmet.2024.02.016. Online ahead of print.NO ABSTRACTPMID:38521058 | DOI:10.1016/j.cmet.2024.02.016 (Source: Cell Metabolism)
Source: Cell Metabolism - March 23, 2024 Category: Cytology Authors: Hung Pham Tara Thompson-Felix Darina Czamara Jerod M Rasmussen Adam Lombroso Sonja Entringer Elisabeth B Binder Pathik D Wadhwa Claudia Buss Kieran J O'Donnell Source Type: research

The effects of pregnancy, its progression, and its cessation on human (maternal) biological aging
Cell Metab. 2024 Mar 19:S1550-4131(24)00079-2. doi: 10.1016/j.cmet.2024.02.016. Online ahead of print.NO ABSTRACTPMID:38521058 | DOI:10.1016/j.cmet.2024.02.016 (Source: Cell Metabolism)
Source: Cell Metabolism - March 23, 2024 Category: Cytology Authors: Hung Pham Tara Thompson-Felix Darina Czamara Jerod M Rasmussen Adam Lombroso Sonja Entringer Elisabeth B Binder Pathik D Wadhwa Claudia Buss Kieran J O'Donnell Source Type: research

Transcriptomic, epigenomic, and spatial metabolomic cell profiling redefines regional human kidney anatomy
This study highlights previously underrepresented cellular heterogeneity underlying the human kidney anatomy.PMID:38513647 | DOI:10.1016/j.cmet.2024.02.015 (Source: Cell Metabolism)
Source: Cell Metabolism - March 21, 2024 Category: Cytology Authors: Haikuo Li Dian Li Nicolas Ledru Qiao Xuanyuan Haojia Wu Amish Asthana Lori N Byers Stefan G Tullius Giuseppe Orlando Sushrut S Waikar Benjamin D Humphreys Source Type: research

Cytosolic pH is a direct nexus in linking environmental cues with insulin processing and secretion in pancreatic β cells
Cell Metab. 2024 Mar 15:S1550-4131(24)00059-7. doi: 10.1016/j.cmet.2024.02.012. Online ahead of print.ABSTRACTPancreatic β cells actively respond to glucose fluctuations through regulating insulin processing and secretion. However, how this process is elaborately tuned in circumstance of variable microenvironments as well as β cell-intrinsic states and whether its dysfunction links to metabolic diseases remain largely elusive. Here, we show that the cytosolic pH (pHc) in β cells is increased upon glucose challenge, which can be sensed by Smad5 via its nucleocytoplasmic shuttling. Lesion of Smad5 in β cells results in h...
Source: Cell Metabolism - March 21, 2024 Category: Cytology Authors: Yujiang Fang Hexi Feng Bowen Zhang Shuwei Zhang Yanjie Zhou Pengcheng Hao Zhongshu Zhou Shanshan Zhou Nan Li Yi Hui Lin Ma Jie Xiong Jinjin Wu Ling Liu Xiaoqing Zhang Source Type: research

Physiologic disruption and metabolic reprogramming in infection and sepsis
Cell Metab. 2024 Mar 13:S1550-4131(24)00058-5. doi: 10.1016/j.cmet.2024.02.013. Online ahead of print.ABSTRACTEffective responses against severe systemic infection require coordination between two complementary defense strategies that minimize the negative impact of infection on the host: resistance, aimed at pathogen elimination, and disease tolerance, which limits tissue damage and preserves organ function. Resistance and disease tolerance mostly rely on divergent metabolic programs that may not operate simultaneously in time and space. Due to evolutionary reasons, the host initially prioritizes the elimination of the pa...
Source: Cell Metabolism - March 21, 2024 Category: Cytology Authors: Katharina Willmann Luis F Moita Source Type: research

Transcriptomic, epigenomic, and spatial metabolomic cell profiling redefines regional human kidney anatomy
This study highlights previously underrepresented cellular heterogeneity underlying the human kidney anatomy.PMID:38513647 | DOI:10.1016/j.cmet.2024.02.015 (Source: Cell Metabolism)
Source: Cell Metabolism - March 21, 2024 Category: Cytology Authors: Haikuo Li Dian Li Nicolas Ledru Qiao Xuanyuan Haojia Wu Amish Asthana Lori N Byers Stefan G Tullius Giuseppe Orlando Sushrut S Waikar Benjamin D Humphreys Source Type: research

Cytosolic pH is a direct nexus in linking environmental cues with insulin processing and secretion in pancreatic β cells
Cell Metab. 2024 Mar 15:S1550-4131(24)00059-7. doi: 10.1016/j.cmet.2024.02.012. Online ahead of print.ABSTRACTPancreatic β cells actively respond to glucose fluctuations through regulating insulin processing and secretion. However, how this process is elaborately tuned in circumstance of variable microenvironments as well as β cell-intrinsic states and whether its dysfunction links to metabolic diseases remain largely elusive. Here, we show that the cytosolic pH (pHc) in β cells is increased upon glucose challenge, which can be sensed by Smad5 via its nucleocytoplasmic shuttling. Lesion of Smad5 in β cells results in h...
Source: Cell Metabolism - March 21, 2024 Category: Cytology Authors: Yujiang Fang Hexi Feng Bowen Zhang Shuwei Zhang Yanjie Zhou Pengcheng Hao Zhongshu Zhou Shanshan Zhou Nan Li Yi Hui Lin Ma Jie Xiong Jinjin Wu Ling Liu Xiaoqing Zhang Source Type: research

Physiologic disruption and metabolic reprogramming in infection and sepsis
Cell Metab. 2024 Mar 13:S1550-4131(24)00058-5. doi: 10.1016/j.cmet.2024.02.013. Online ahead of print.ABSTRACTEffective responses against severe systemic infection require coordination between two complementary defense strategies that minimize the negative impact of infection on the host: resistance, aimed at pathogen elimination, and disease tolerance, which limits tissue damage and preserves organ function. Resistance and disease tolerance mostly rely on divergent metabolic programs that may not operate simultaneously in time and space. Due to evolutionary reasons, the host initially prioritizes the elimination of the pa...
Source: Cell Metabolism - March 21, 2024 Category: Cytology Authors: Katharina Willmann Luis F Moita Source Type: research

Impaired skeletal muscle regeneration in diabetes: From cellular and molecular mechanisms to novel treatments
We describe the role of myogenic and non-myogenic cell types on muscle regeneration in conditions with or without diabetes. Therapies for skeletal muscle regeneration and gaps in our knowledge are also discussed, while proposing future directions for the field.PMID:38490209 | DOI:10.1016/j.cmet.2024.02.014 (Source: Cell Metabolism)
Source: Cell Metabolism - March 15, 2024 Category: Cytology Authors: Ever Espino-Gonzalez Emilie Dalbram R émi Mounier Julien Gondin Jean Farup Niels Jessen Jonas T Treebak Source Type: research

Judith Campisi (1948-2024)
Cell Metab. 2024 Mar 11:S1550-4131(24)00080-9. doi: 10.1016/j.cmet.2024.03.001. Online ahead of print.NO ABSTRACTPMID:38490210 | DOI:10.1016/j.cmet.2024.03.001 (Source: Cell Metabolism)
Source: Cell Metabolism - March 15, 2024 Category: Cytology Authors: Eric Verdin Source Type: research

Acetyl-CoA carboxylase obstructs CD8 < sup > + < /sup > T  cell lipid utilization in the tumor microenvironment
Cell Metab. 2024 Mar 11:S1550-4131(24)00055-X. doi: 10.1016/j.cmet.2024.02.009. Online ahead of print.ABSTRACTThe solid tumor microenvironment (TME) imprints a compromised metabolic state in tumor-infiltrating T cells (TILs), hallmarked by the inability to maintain effective energy synthesis for antitumor function and survival. T cells in the TME must catabolize lipids via mitochondrial fatty acid oxidation (FAO) to supply energy in nutrient stress, and it is established that T cells enriched in FAO are adept at cancer control. However, endogenous TILs and unmodified cellular therapy products fail to sustain bioenergetics ...
Source: Cell Metabolism - March 15, 2024 Category: Cytology Authors: Elizabeth G Hunt Katie E Hurst Brian P Riesenberg Andrew S Kennedy Evelyn J Gandy Alex M Andrews Coral Del Mar Alicea Pauneto Lauren E Ball Emily D Wallace Peng Gao Jeremy Meier John J Serody Michael F Coleman Jessica E Thaxton Source Type: research

Impaired skeletal muscle regeneration in diabetes: From cellular and molecular mechanisms to novel treatments
We describe the role of myogenic and non-myogenic cell types on muscle regeneration in conditions with or without diabetes. Therapies for skeletal muscle regeneration and gaps in our knowledge are also discussed, while proposing future directions for the field.PMID:38490209 | DOI:10.1016/j.cmet.2024.02.014 (Source: Cell Metabolism)
Source: Cell Metabolism - March 15, 2024 Category: Cytology Authors: Ever Espino-Gonzalez Emilie Dalbram R émi Mounier Julien Gondin Jean Farup Niels Jessen Jonas T Treebak Source Type: research

Judith Campisi (1948-2024)
Cell Metab. 2024 Mar 11:S1550-4131(24)00080-9. doi: 10.1016/j.cmet.2024.03.001. Online ahead of print.NO ABSTRACTPMID:38490210 | DOI:10.1016/j.cmet.2024.03.001 (Source: Cell Metabolism)
Source: Cell Metabolism - March 15, 2024 Category: Cytology Authors: Eric Verdin Source Type: research

Acetyl-CoA carboxylase obstructs CD8 < sup > + < /sup > T  cell lipid utilization in the tumor microenvironment
Cell Metab. 2024 Mar 11:S1550-4131(24)00055-X. doi: 10.1016/j.cmet.2024.02.009. Online ahead of print.ABSTRACTThe solid tumor microenvironment (TME) imprints a compromised metabolic state in tumor-infiltrating T cells (TILs), hallmarked by the inability to maintain effective energy synthesis for antitumor function and survival. T cells in the TME must catabolize lipids via mitochondrial fatty acid oxidation (FAO) to supply energy in nutrient stress, and it is established that T cells enriched in FAO are adept at cancer control. However, endogenous TILs and unmodified cellular therapy products fail to sustain bioenergetics ...
Source: Cell Metabolism - March 15, 2024 Category: Cytology Authors: Elizabeth G Hunt Katie E Hurst Brian P Riesenberg Andrew S Kennedy Evelyn J Gandy Alex M Andrews Coral Del Mar Alicea Pauneto Lauren E Ball Emily D Wallace Peng Gao Jeremy Meier John J Serody Michael F Coleman Jessica E Thaxton Source Type: research