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Targeted therapy of spinal cord glioma with a genetically modified Salmonella typhimuriumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results suggest that S. typhimurium A1-R monotherapy can effectively treat spinal cord glioma. (Source: Cell Proliferation)
Source: Cell Proliferation - November 19, 2009 Category: Cytology Authors: H. Kimura, L. Zhang, M. Zhao, K. Hayashi, H. Tsuchiya, K. Tomita, M. Bouvet, J. Wessels, R. M. Hoffman Source Type: journals

Sub-millimolar concentration of the novel phenol-based compound, 2-hydroxy benzoate zinc, induces apoptosis in human HT-1080 fibrosarcoma cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results demonstrate that the novel phenolic compound 2HBZ is a potent apoptosis-inducing agent in HT-1080 cells and warrants further investigation as a potential chemotherapeutic agent in primary cancer cell models. (Source: Cell Proliferation)
Source: Cell Proliferation - November 18, 2009 Category: Cytology Authors: J. G. Mahdi, C. J. Pepper, M. A. Alkarrawi, A. J. Mahdi, I. D. Bowen Source Type: journals

The role of scaffold proteins in JNK signallingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This paper summarises how scaffold proteins affects and regulate the JNK signalling pathway. We believe that some of these scaffold proteins, by virtue of their anchoring and catalytic properties contribute to a high degree of specificity of intra cellular signalling pathways that regulate the progression through the cell cycle. (Source: Cell Proliferation)
Source: Cell Proliferation - November 17, 2009 Category: Cytology Authors: W. Engström, A. Ward, K. Moorwood Source Type: journals

Anti-proliferative effects of γ-tocotrienol on mammary tumour cells are associated with suppression of cell cycle progressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Objectives: Previous studies have shown that [gamma]-tocotrienol induces potent anti-proliferative effects on +SA mammary tumour cells in culture; here, investigations have been conducted to determine its effects on intracellular signalling proteins involved in regulating cell cycle progression.Materials and methods: +SA cells were maintained in mitogen-free defined media containing 0 or 4 [mu]m[gamma]-tocotrienol, for 48 h to synchronize cell cycle in G0 phase, and then they were exposed to 100 ng/ml EGF to initiate cell cycle progression. Whole cell lysates were collected at various time points from each treatment group ...
Source: Cell Proliferation - November 17, 2009 Category: Cytology Authors: G. V. Samant, V. B. Wali, P. W. Sylvester Source Type: journals

Cellular responses and expression profiling of human bone marrow stromal cells stimulated with enamel matrix proteins in vitroEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: EMPs promoted cell proliferation and differentiation and gene expression profiles of HBMSCs were affected. This may help elucidation of mechanisms involved in promoting regeneration of periodontal tissues by EMPs. (Source: Cell Proliferation)
Source: Cell Proliferation - November 17, 2009 Category: Cytology Authors: Z. C. Song, R. Shu, X. L. Zhang Source Type: journals

Involvement of fibroblast growth factor 18 in dedifferentiation of cultured human chondrocytesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: FGF18 seems to play a role in maintenance of chondrocyte properties, although its expression was rather high in dedifferentiated chondrocytes. Upregulation of FGF18 in dedifferentiated chondrocytes implied that it may be a marker of dedifferentiation. (Source: Cell Proliferation)
Source: Cell Proliferation - November 10, 2009 Category: Cytology Authors: H. Yamaoka, S. Nishizawa, Y. Asawa, Y. Fujihara, T. Ogasawara, K. Yamaoka, S. Nagata, T. Takato, K. Hoshi Source Type: journals

Heparin regulates colon cancer cell growth through p38 mitogen-activated protein kinase signallingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This study demonstrates that an extracellular glycosaminoglycan, heparin, finely modulates expression of genes crucial to cell cycle regulation through specific activation of p38 MAP kinase to stimulate colon cancer cell growth. (Source: Cell Proliferation)
Source: Cell Proliferation - October 20, 2009 Category: Cytology Authors: G. Chatzinikolaou, D. Nikitovic, A. Berdiaki, A. Zafiropoulos, P. Katonis, N. K. Karamanos, G. N. Tzanakakis Source Type: journals

Expression and role of Oct3/4, Nanog and Sox2 in regeneration of rat tracheal epitheliumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: G0 phase cells with resistance to 5-FU damage expressed Oct3/4, Nanog and Sox2. This indicated that these cells were undifferentiated, but had the ability to terminally differentiate into downstream-type cells. They possessed stem cell properties. The results are consistent with Oct3/4, Nanog and Sox2-expressing cells being considered as tracheal stem cells. (Source: Cell Proliferation)
Source: Cell Proliferation - October 20, 2009 Category: Cytology Authors: N. Song, X.-S. Jia, L.-L. Jia, X.-B. Ma, F. Li, E.-H. Wang, X. Li Source Type: journals

Effect of syndecan-1 overexpression on mesenchymal tumour cell proliferation with focus on different functional domainsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Both full-length and truncated syndecan-1 inhibited proliferation of the mesenchymal tumour cells, providing new insights into the importance for cancer growth of different functional domains of this proteoglycan. (Source: Cell Proliferation)
Source: Cell Proliferation - October 13, 2009 Category: Cytology Authors: F. Zong, E. Fthenou, J. Castro, B. Péterfia, I. Kovalszky, L. Szilák, G. Tzanakakis, K. Dobra Source Type: journals

The stem cells of small intestinal crypts: where are they?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Recently, there has been resurgence of interest in the question of small intestinal stem cells, their precise location and numbers in the crypts. In this article, we attempt to re-assess the data, including historical information often omitted in recent studies on the subject. The conclusion we draw is that the evidence supports the concept that active murine small intestinal stem cells in steady state are few in number and are proliferative. There are two evolving, but divergent views on their location (which may be more related to scope of capability and reversibility than to location) several lineage labelling and stem ...
Source: Cell Proliferation - September 27, 2009 Category: Cytology Authors: C. S. Potten, R. Gandara, Y. R. Mahida, M. Loeffler, N. A. Wright Source Type: journals

Pharmacokinetic and pharmacodynamic modelling of the novel human granulocyte colony-stimulating factor derivative Maxy-G34 and pegfilgrastim in ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Maxy-G34 is a highly potent drug for stimulation of neutrophil production in rats. By our modelling approach, we quantified differences between Maxy-G34 and pegfilgrastim, related to pharmacokinetic parameters. Model simulations can be used to estimate optimal dosing and timing options in the present preclinical rat model. (Source: Cell Proliferation)
Source: Cell Proliferation - September 24, 2009 Category: Cytology Authors: M. Scholz, C. Engel, D. Apt, S. L. Sankar, E. Goldstein, M. Loeffler Source Type: journals

Three clonal types of urothelium with different capacities for replicationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Type-3 cells in the centre of T-III colonies appear to harbour stem-like qualities with a relatively low proliferative and apoptotic index at homeostasis and the ability to become highly proliferative upon passage. This study demonstrates that distinct urothelial cell types with differing clonal capacities can be isolated from the bladder and these cells may have implications for tissue engineering and carcinogenesis. (Source: Cell Proliferation)
Source: Cell Proliferation - September 17, 2009 Category: Cytology Authors: R. Thangappan, E. A. Kurzrock Source Type: journals

Umbilical cord blood processing using Prepacyte-CB increases haematopoietic progenitor cell availability over conventional Hetastarch separationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results show that PrepaCyte-CB offers superior separation of UCB when compared to Hetastarch. (Source: Cell Proliferation)
Source: Cell Proliferation - September 14, 2009 Category: Cytology Authors: C. Basford, N. Forraz, S. Habibollah, K. Hanger, C. P. McGuckin Source Type: journals

ADAM-mediated amphiregulin shedding and EGFR transactivation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These findings show that non-transformed and transformed prostate epithelial cells may employ different mechanisms to activate EGFR ligands and thereby utilize the EGFR axis to promote cellular proliferation. (Source: Cell Proliferation)
Source: Cell Proliferation - September 6, 2009 Category: Cytology Authors: S. Kasina, P. A. Scherle, C. L. Hall, J. A. Macoska Source Type: journals

Human embryonic stem cells secrete soluble factors that inhibit cancer cell growthEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our findings provide evidence that the human embryonic microenvironment contains soluble factor(s) that are capable of inhibiting growth of cancer cells, and that exposure to such factors may represent a new cancer treatment strategy. (Source: Cell Proliferation)
Source: Cell Proliferation - September 1, 2009 Category: Cytology Authors: D. Giuffrida, I. M. Rogers, A. Nagy, A. E. Calogero, T. J. Brown, R. F. Casper Source Type: journals

Aspirin induces apoptosis in mesenchymal stem cells requiring Wnt/β-catenin pathwayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These results demonstrate that the Wnt/[beta]-catenin pathway is a key modulator of aspirin-induced apoptosis in MSCs by regulation of mitochrondrial/caspase-3 function. More importantly, our findings suggest that aspirin may influence MSC survival under certain conditions; therefore, it should be used with caution when considering regenerative MSC transplantation in patients with concomitant chronic inflammatory diseases such as arthritis. (Source: Cell Proliferation)
Source: Cell Proliferation - August 25, 2009 Category: Cytology Authors: L. Deng, S. Hu, A. R. Baydoun, J. Chen, X. Chen, X. Cong Source Type: journals

Differential effects of Nucleostemin suppression on cell cycle arrest and apoptosis in the bladder cancer cell lines 5637 and SW1710Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our data indicate that NS expression is necessary for cell proliferation and evasion of apoptosis in bladder cancer cells, independent of its effect on p53. Also, we speculate that the precise effect of NS on cell cycle regulation may relate to functional status of RB1 and CDKN2A/p16INK4A. (Source: Cell Proliferation)
Source: Cell Proliferation - August 24, 2009 Category: Cytology Authors: P. Nikpour, S. J. Mowla, S. M. Jafarnejad, U. Fischer, W. A. Schulz Source Type: journals

A pharmacokinetic model of filgrastim and pegfilgrastim application in normal mice and those with cyclophosphamide-induced granulocytopaeniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Dynamics of filgrastim and pegfilgrastim plasma levels can be explained by the same pharmacokinetic model but different model parameters. Beause of a strong clearance mechanism mediated by granulocytes, granulocytotic and granulocytopaenic conditions must be studied simultaneously to construct a reliable model. The pharmacokinetic model will be extended to a murine model of granulopoiesis under chemotherapy and G-CSF application. (Source: Cell Proliferation)
Source: Cell Proliferation - August 17, 2009 Category: Cytology Authors: M. Scholz, M. Ackermann, C. Engel, F. Emmrich, M. Loeffler, M. Kamprad Source Type: journals

Ability of the polysaccharide chitosan to inhibit proliferation of CD4+ lymphocytes from mucosal inductive sites, in vitro and in vivoEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Here we demonstrate the ability of chitosan to suppress proliferation of CD4+ lymphocytes from mucosal inductive sites in vivo and in vitro This effect could be relevant in modulatory activity of chitosan in the intestinal microenvironment. (Source: Cell Proliferation)
Source: Cell Proliferation - August 16, 2009 Category: Cytology Authors: C. Porporatto, M. M. Canali, I. D. Bianco, S. G. Correa Source Type: journals

Histone deacetylase inhibitors decrease proliferation potential and multilineage differentiation capability of human mesenchymal stem cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: HDAC activity is essential for maintaining the self-renewal and pluripotency of MSCs. (Source: Cell Proliferation)
Source: Cell Proliferation - August 16, 2009 Category: Cytology Authors: S. Lee, J-R. Park, M-S. Seo, K-H. Roh, S-B. Park, J-W. Hwang, B. Sun, K. Seo, Y-S. Lee, S-K. Kang, J-W. Jung, K-S. Kang Source Type: journals

Ecology-based screen identifies new metabolites from a Cordyceps-colonizing fungus as cancer cell proliferation inhibitors and apoptosis inducersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Gliocladicillins A (1) and B (2) are effective anti-tumour agents in vitro and in vivo and should be further evaluated for their potential in clinical use. (Source: Cell Proliferation)
Source: Cell Proliferation - August 10, 2009 Category: Cytology Authors: Y. Chen, H. Guo, Z. Du, X.-Z. Liu, Y. Che, X. Ye Source Type: journals

An integrative computational model for intestinal tissue renewalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We demonstrate that relaxing the assumption that stem-cell positions are fixed enables clonal expansion and niche succession to occur. We also predict that the presence of extracellular factors near the base of the crypt alone suffices to explain the observed spatial variation in nuclear beta-catenin levels along the crypt axis. (Source: Cell Proliferation)
Source: Cell Proliferation - July 19, 2009 Category: Cytology Authors: I. M. M. van Leeuwen, G. R. Mirams, A. Walter, A. Fletcher, P. Murray, J. Osborne, S. Varma, S. J. Young, J. Cooper, B. Doyle, J. Pitt-Francis, L. Momtahan, P. Pathmanathan, J. P. Whiteley, S. J. Chapman, D. J. Gavaghan, O. E. Jensen, J. R. King, P. K. Ma Source Type: journals

Hybrid mathematical model of glioma progressionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This model is used to perform multiple simulations to determine sensitivity to changes in important model parameters, specifically, the fundamental length parameter, necrotic cell degradation rate, rate of cell migration, and rate of phenotype transformation. Using these values, the model is able to simulate tumour growth and invasion behaviour, observed clinically. This mathematical model provides a means to simulate various tumour development scenarios, which may lead to a better understanding of how altering fundamental parameters can influence neoplastic progression. (Source: Cell Proliferation)
Source: Cell Proliferation - July 16, 2009 Category: Cytology Authors: M. L. Tanaka, W. Debinski, I. K. Puri Source Type: journals

Intestinal metaplasia in liver of rats after partial hepatectomy and treatment with acetylaminofluoreneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The existence of this phenotype (along with oval cells and small hepatocyte-like cells) is evidence of multipotency of progenitors involved in the hepatic healing response. (Source: Cell Proliferation)
Source: Cell Proliferation - July 16, 2009 Category: Cytology Authors: V. Barut, C. E. Sarraf Source Type: journals

Promotion of stem cell proliferation by vegetable peptoneEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our findings revealed that the vegetable peptone promotes proliferation of CB-MSCs and ADSCs. In addition, results of this study suggest that induction of stem cell proliferation by vegetable peptone is likely to be related to its induction of VEGF, TGF-[beta]1, and IL-6 expression. (Source: Cell Proliferation)
Source: Cell Proliferation - July 14, 2009 Category: Cytology Authors: J. Lee, J. Lee, H. Hwang, E. Jung, S. Huh, J. Hyun, D. Park Source Type: journals

Human immature dental pulp stem cells share key characteristic features with limbal stem cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Objectives: Limbal stem cells (LSC) are self-renewing, highly proliferative cells in vitro, which express a set of specific markers and in vivo have the capacity to reconstruct the entire corneal epithelium in cases of ocular surface injury. Currently, LSC transplantation is a commonly used procedure in patients with either uni- or bilateral total limbal stem cells deficiency (TLSCD). Although LSC transplantation holds great promise for patients, several problems need to be overcome. In order to find an alternative source of cells that can partially substitute LSC in cornea epithelium reconstruction, we aimed at investigat...
Source: Cell Proliferation - July 13, 2009 Category: Cytology Authors: B. G. Monteiro, R. C. Serafim, G. B. Melo, M. C. P. Silva, N. F. Lizier, C. M. C. Maranduba, R. L. Smith, A. Kerkis, H. Cerruti, J. A. P. Gomes, I. Kerkis Source Type: journals

Amyloid beta-derived neuroplasticity in bone marrow-derived mesenchymal stem cells is mediated by NPY and 5-HT2B receptors via ERK1/2 signalling pathwaysEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Objective: In Alzheimer's disease, toxic soluble and insoluble forms of amyloid beta (A[beta]) cause synaptic dysfunction and neuronal loss. Given its potential role in producing a toxic host microenvironment for transplanted donor stem cells, we investigated the interaction between A[beta] and proliferation, survival, and differentiation of bone marrow-derived mesenchymal stem cells (BM-MSC) in culture.Materials and methods: We used BM-MSC that had been isolated from mouse bone marrow and cultured, and we also assessed relevant reaction mechanisms using gene microarray, immunocytochemistry, and inhibitors of potential sig...
Source: Cell Proliferation - July 13, 2009 Category: Cytology Authors: H. K. Jin, J. S. Bae, S. Furuya, J. E. Carter Source Type: journals

Experimental analysis and modelling of in vitro proliferation of mesenchymal stem cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Objectives: Stem cell therapies based on differentiation of adult or embryonic stem cells into specialized ones appear to be effective for treating several human diseases. This work addresses the mathematical simulation of proliferation kinetics of stem cells.Materials and methods: Sheep bone marrow mesenchymal stem cells (phenotype characterized by flow cytometry analysis) seeded at different initial concentrations in Petri dishes were expanded to confluence. Sigmoid temporal profiles of total counts obtained through classic haemocytometry were quantitatively interpreted by both a phenomenological logistic equation and a ...
Source: Cell Proliferation - July 9, 2009 Category: Cytology Authors: L. Mancuso, M. I. Liuzzo, S. Fadda, M. Pisu, A. Cincotti, M. Arras, E. Desogus, F. Piras, G. Piga, G. La Nasa, A. Concas, G. Cao Source Type: journals

Structurally diverse peroxisome proliferator-activated receptor agonists induce apoptosis in human uro-epithelial cells by a receptor-independent mechanism involving store-operated calcium channelsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results provide a mechanistic basis for the ability of some PPAR agonists to induce death in NHU cells and demonstrate that apoptosis is mediated via PPAR-independent mechanisms, involving intracellular calcium changes, activation of SOCs and induction of the mitochondrial apoptotic pathway. (Source: Cell Proliferation)
Source: Cell Proliferation - July 9, 2009 Category: Cytology Authors: B. Chopra, N. T. Georgopoulos, A. Nicholl, J. Hinley, M. B. Oleksiewicz, J. Southgate Source Type: journals

Co-treatment with deoxycholic acid and azoxymethane accelerates secretion of HMGB1 in IEC6 intestinal epithelial cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These findings suggest that DCA affects intracellular localization and secretion of HMGB1. (Source: Cell Proliferation)
Source: Cell Proliferation - July 8, 2009 Category: Cytology Authors: K. Fujii, Y. Luo, T. Sasahira, A. Denda, H. Ohmori, H. Kuniyasu Source Type: journals

Crucial role of the local micro-environment in fate decision of neonatal rat NG2 progenitorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The neuronal micro-environment provided by the culture of hippocampal slices is potent for induction of neurogenesis from oligodendrocyte NG2+/PDGFR[alpha]+/CNP+ progenitor cells and promotes their differentiation not only into macroglia but also into neurons. It also sustains their proliferative capacity. The results indicate the crucial role of the local cellular environment in fate decision of primary NG2+ multipotent neural progenitor cells, which may affect their behaviour after transplantation into the central nervous system. (Source: Cell Proliferation)
Source: Cell Proliferation - July 8, 2009 Category: Cytology Authors: J. Sypecka, A. Sarnowska, K. Domanska-Janik Source Type: journals

Transglutaminase down-regulates the dimerization of epidermal growth factor receptor in rat perivenous and periportal hepatocytesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The present data showed good correlation with our previous data on EGF-induced DNA synthesis and EGFR-binding affinity to EGF. These results suggest that zonal difference in cell growth between PPH and PVH may be caused by down-regulation of EGFR dimerization and subsequent autophosphorylation through TG2-mediated cross-linking of EGFR. (Source: Cell Proliferation)
Source: Cell Proliferation - July 8, 2009 Category: Cytology Authors: A. Maruko, Y. Ohtake, S. Katoh, Y. Ohkubo Source Type: journals

Gender differences in pulmonary regenerative response to naphthalene-induced bronchiolar epithelial cell injuryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These findings show that there are clear gender differences in naphthalene-induced lung injury and repair. (Source: Cell Proliferation)
Source: Cell Proliferation - July 8, 2009 Category: Cytology Authors: J. R. Oliver, R. Kushwah, J. Wu, E. Cutz, H. Yeger, T. K. Waddell, J. Hu Source Type: journals

CorrigendumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Cell Proliferation)
Source: Cell Proliferation - June 28, 2009 Category: Cytology Tags: Corrigendum Source Type: journals

ErratumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Cell Proliferation)
Source: Cell Proliferation - June 28, 2009 Category: Cytology Tags: Erratum Source Type: journals

Impact of oxygen environment on mesenchymal stem cell expansion and chondrogenic differentiationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our approach provides new insights into organization of MSC populations in vitro. The results suggest that MSC differentiation is largely reversible and that lineage plasticity is restricted to stem cells and early progenitors. The model predicts a significant impact of short-term low oxygen treatment on MSC differentiation and optimal chondrogenic differentiation at 10[ndash]11% pO2. (Source: Cell Proliferation)
Source: Cell Proliferation - June 28, 2009 Category: Cytology Authors: A. Krinner, M. Zscharnack, A. Bader, D. Drasdo, J. Galle Tags: Original Articles Source Type: journals

Characterization of brain cancer stem cells: a mathematical approachEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Objective: In recent years, support has increased for the notion that a subpopulation of brain tumour cells in possession of properties typically characteristic of stem cells is responsible for initiating and maintaining the tumour. Unravelling details of the brain tumour stem cell (BTSC) hierarchy, as well as interactions of these cells with various therapies, will be essential in the design of optimal treatment strategies.Materials and methods: Motivated by this, we have developed a mathematical model of the BTSC hypothesis that may aid in characterization of brain tumours, as well as in prediction of effective therapeut...
Source: Cell Proliferation - June 24, 2009 Category: Cytology Authors: C. Turner, A. R. Stinchcombe, M. Kohandel, S. Singh, S. Sivaloganathan Source Type: journals

Transmitochondrial embryonic stem cells containing pathogenic mtDNA mutations are compromised in neuronal differentiationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Differentiated neurons carrying severely pathogenic mtDNA defects can provide a useful model for understanding how such mutations can cause neuronal dysfunction. (Source: Cell Proliferation)
Source: Cell Proliferation - June 22, 2009 Category: Cytology Authors: D. M. Kirby, K. J. Rennie, T. K. Smulders-Srinivasan, R. Acin-Perez, M. Whittington, J.-A. Enriquez, A. J. Trevelyan, D. M. Turnbull, R. N. Lightowlers Source Type: journals

Effects of ultraviolet radiation on human cutaneous nerve fibresEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Quantification of cell damage induced by UV radiation provides useful information for identification of new skin care compounds with neuroprotective properties. (Source: Cell Proliferation)
Source: Cell Proliferation - June 8, 2009 Category: Cytology Authors: A. L. Rodriguez, F. S. Stefani, C. E. de Oliveira Praes, A. Piaceski, M. P. Oliveira, P. Martins, V. D. da Silva, C. Bonorino, M. E. Bauer Source Type: journals

Downregulation of cell survival signalling pathways and increased cell damage in hydrogen peroxide-treated human renal proximal tubular cells by alpha-erythropoietinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Erythropoietin, at high concentrations, may significantly increase cellular damage in HK-2 cells subjected to oxidative stress, which may be due in part to decrease in activation of important signalling pathways involved in cell survival and/or cell proliferation. (Source: Cell Proliferation)
Source: Cell Proliferation - June 8, 2009 Category: Cytology Authors: M. Andreucci, G. Fuiano, P. Presta, G. Lucisano, F. Leone, L. Fuiano, V. Bisesti, P. Esposito, D. Russo, B. Memoli, T. Faga, A. Michael Source Type: journals

Noggin maintains pluripotency of human embryonic stem cells grown on MatrigelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Noggin can be utilized for short term prevention of spontaneous differentiation of stem cells grown on Matrigel. (Source: Cell Proliferation)
Source: Cell Proliferation - June 5, 2009 Category: Cytology Authors: G. Chaturvedi, P. D. Simone, R. Ain, M. J. Soares, M. W. Wolfe Source Type: journals

Impaired in vivo vasculogenic potential of endothelial progenitor cells in comparison to human umbilical vein endothelial cells in a spheroid-based implantation modelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our results indicate that vascular-derived endothelial cells, such as HUVECs are superior to EPCs in terms of promoting in vivo vascularization of engineered tissues. (Source: Cell Proliferation)
Source: Cell Proliferation - May 28, 2009 Category: Cytology Authors: G. Finkenzeller, S. Graner, C. J. Kirkpatrick, S. Fuchs, G. B. Stark Source Type: journals

Isolation and characterization of multipotent stem cells from human cruciate ligamentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In summary, our study demonstrates that human multipotent stem cells can be isolated and expanded from human ACL and PCL, which are easily obtained from patients following total knee or cruciate ligament reconstructive surgery. Self-renewal and mesodermal differentiation potential of these cells make them a viable alternative source for use in regenerative medicine. (Source: Cell Proliferation)
Source: Cell Proliferation - May 28, 2009 Category: Cytology Authors: M-T. Cheng, H-W. Yang, T-H. Chen, O. K-S. Lee Source Type: journals

Isolation and characterization of stem cells from the human parathyroid glandEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results reveal that PDSCs were similar phenotypically to MSCs and further studies are needed to formulate induction conditions to differentiate PDSCs into parathyroid hormone-secreting chief cells. (Source: Cell Proliferation)
Source: Cell Proliferation - May 28, 2009 Category: Cytology Authors: Y-R. V. Shih, T. K. Kuo, A-H. Yang, O. K. Lee, C-H. Lee Source Type: journals

Effect of raloxifene on vascular endothelial growth factor expression in breast carcinomas of postmenopausal womenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Raloxifene significantly reduced VEGF expression in these oestrogen receptor-positive breast carcinomas of postmenopausal women. (Source: Cell Proliferation)
Source: Cell Proliferation - May 28, 2009 Category: Cytology Authors: B. B. da Silva, A. R. dos Santos, C. G. Pires, P. V. Lopes-Costa Source Type: journals

Virtual glioblastoma: growth, migration and treatment in a three-dimensional mathematical modelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The model provides a useful initial framework by which biological mechanisms of invasion and efficacy of potential treatment regimens may be assessed. (Source: Cell Proliferation)
Source: Cell Proliferation - May 28, 2009 Category: Cytology Authors: S. E. Eikenberry, T. Sankar, M. C. Preul, E. J. Kostelich, C. J. Thalhauser, Y. Kuang Source Type: journals

Microtubule-interacting drugs induce moderate and reversible damage to human bone marrow mesenchymal stem cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study aimed to investigate molecular and cellular changes induced in human bone marrow mesenchymal stem cells (hMSCs) after treatment with microtubule-interacting agents and to estimate damage to the bone marrow microenvironment caused by chemotherapy.Materials and methods: Using an in vitro hMSC culture system and biochemical and morphological approaches, we studied the effect of nocodazole and taxol® on microtubule and nuclear envelope organization, tubulin and p53 synthesis, cell cycle progression and proliferation and death of hMSCs isolated from healthy donors.Results and conclusions: Both nocodazole and taxol r...
Source: Cell Proliferation - May 21, 2009 Category: Cytology Authors: H. Polioudaki, M.-C. Kastrinaki, H. A. Papadaki, P. A. Theodoropoulos Source Type: journals

Rapid prototyping of anatomically shaped, tissue-engineered implants for restoring congruent articulating surfaces in small jointsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Anatomically shaped, tissue-engineered constructs with designed mechanical properties and internal pore architectures may offer alternatives for reconstruction or restoration of congruent articulating surfaces in small joints. (Source: Cell Proliferation)
Source: Cell Proliferation - May 21, 2009 Category: Cytology Authors: T. B. F. Woodfield, M. Guggenheim, B. von Rechenberg, J. Riesle, C. A. van Blitterswijk, V. Wedler Source Type: journals