Use of platelet rich plasma for skin rejuvenation
CONCLUSION: This study underscores the efficacy of PRP monotherapy for skin rejuvenation and emphasizes the necessity of standardizing PRP preparation protocols in future investigations. Heightened awareness and advancements in technology have contributed to the emergence of higher-quality, less biased studies supporting PRP as a reliable and safe therapeutic option for skin rejuvenation.PMID:38650371 | DOI:10.1111/srt.13714 (Source: Cell Research)
Source: Cell Research - April 23, 2024 Category: Cytology Authors: Lam Kar Wai Phoebe Kar Wai Alvin Lee Lisa Kwin Wah Chan Lee Cheuk Hung Raymond Wu Sky Wong Jovian Wan Kyu-Ho Yi Source Type: research
The Tumor Immune Microenvironment Is Associated With Recurrence in Early-Stage Lung Adenocarcinoma
CONCLUSIONS: PD-L1 expression on tumor cells, CD8+ T cell infiltration, and TP53 mutation status may help identify patients with early-stage NSCLC susceptible to recurrence after adjuvant chemotherapy.PMID:38651033 | PMC:PMC11033192 | DOI:10.1016/j.jtocrr.2024.100658 (Source: Cell Research)
Source: Cell Research - April 23, 2024 Category: Cytology Authors: Hiroaki Kanemura Toshihide Yokoyama Ryu Nakajima Atsushi Nakamura Hiroaki Kuroda Yoshitaka Kitamura Hiroyasu Shoda Nobuaki Mamesaya Yoshihiro Miyata Tatsuro Okamoto Kyoichi Okishio Masahide Oki Yuichi Sakairi Toyofumi Fengshi Chen-Yoshikawa Tadashi Aoki T Source Type: research
Forensic efficiency and population genetic construction of Guizhou Gelao minority from Southwest China revealed by a panel of 23 autosomal STR loci
Forensic Sci Res. 2024 Jan 5;9(2):owad058. doi: 10.1093/fsr/owad058. eCollection 2024 Jun.ABSTRACTShort tandem repeats (STRs) are the most common genetic markers in forensic and human population genetics due to their high polymorphism, rapid detection, and reliable genotyping. To adapt the rapid growth of forensic DNA database and solve problems in disputed cases, a panel of 23 autosomal STR loci with high discriminating ability was constructed recently. The Tai-Kadai-speaking Gelao is the most ancient indigenous minority in Guizhou province, however, the forensic efficiency and population genetic structure remain poorly e...
Source: Cell Research - April 23, 2024 Category: Cytology Authors: Siyu Chai Shuhua Li Ruxin Zhu Li Luo Kaiqin Chen Yinlei Lei Weihong Wan Xijie Hu Shiquan Liu Pengyu Chen Source Type: research
Increased glutamatergic neurotransmission between the retinohypothalamic tract and the suprachiasmatic nucleus of old mice
J Neurosci Res. 2024 Apr;102(4):e25331. doi: 10.1002/jnr.25331.ABSTRACTCircadian rhythms synchronize to light through the retinohypothalamic tract (RHT), which is a bundle of axons coming from melanopsin retinal ganglion cells, whose synaptic terminals release glutamate to the ventral suprachiasmatic nucleus (SCN). Activation of AMPA-kainate and NMDA postsynaptic receptors elicits the increase in intracellular calcium required for triggering the signaling cascade that ends in phase shifts. During aging, there is a decline in the synchronization of circadian rhythms to light. With electrophysiological (whole-cell patch-clam...
Source: Cell Research - April 23, 2024 Category: Cytology Authors: J Manuel Herrera-Zamora Fernando Osuna-Lopez Miriam E Reyes-M éndez Ramon E Valadez-Lemus Enrique A S ánchez-Pastor Ricardo A Navarro-Polanco Eloy G Moreno-Galindo Javier Alamilla Source Type: research
Ablation of the integrin CD11b mac-1 limits deleterious responses to traumatic spinal cord injury and improves functional recovery in mice
Conclusion: Collectively, our data suggest an important role for CD11b in regulating tissue inflammation and functional outcome following SCI. Thus, the integrin CD11b represents a potential target that may lead to novel therapeutic strategies for SCI.PMID:38645238 | PMC:PMC11030505 | DOI:10.21203/rs.3.rs-4196316/v1 (Source: Cell Research)
Source: Cell Research - April 22, 2024 Category: Cytology Authors: Yun Li Rodney M Ritzel Junyun He Simon Liu Li Zhang Junfang Wu Source Type: research
CD59 Protects Primary Human Cerebrovascular Smooth Muscle Cells from Cytolytic Membrane Attack Complex
Res Sq [Preprint]. 2024 Apr 1:rs.3.rs-4165045. doi: 10.21203/rs.3.rs-4165045/v1.ABSTRACTCerebral amyloid angiopathy is characterized by a weakening of the small and medium sized cerebral arteries, as their smooth muscle cells are progressively replaced with acellular amyloid β, increasing vessel fragility and vulnerability to microhemorrhage. In this context, an aberrant overactivation of the complement system would further aggravate this process. The surface protein CD59 protects most cells from complement-induced cytotoxicity, but expression levels can fluctuate due to disease and vary between cell types. The degree to ...
Source: Cell Research - April 22, 2024 Category: Cytology Authors: Carson Whinnery Ying Nie Danilo S Boskovic Salvador Soriano Wolff M Kirsch Source Type: research
Expression of c-erb-B2 oncoprotein as a neoantigen strategy to repurpose anti-neu antibody therapy in a model of melanoma
In this study, we tested a novel approach of "repurposing" a biomarker typically associated with breast cancer for use in melanoma. HER2/neu is a well characterized biomarker in breast cancer for which effective anti-HER2/neu therapies are readily available. We constructed a lentivirus encoding c-erb-B2 (the animal homolog to HER2/neu). This was used to transfect B16 melanoma in vitro for use in an orthotopic preclinical mouse model, which resulted in expression of c-erb-B2 as a neoantigen target for anti-c-erb-B2 monoclonal antibody (7.16.4). The c-erb-B2-expressing melanoma was designated B16/neu. 7.16.4 produced statist...
Source: Cell Research - April 22, 2024 Category: Cytology Authors: Emmanuel M Gabriel Brian Necela Deborah Bahr Sneha Vivekanandhan Barath Shreeder Sanjay Bagaria Keith L Knutson Source Type: research
Hyperosmotic Sisomicin Infusion: A Mouse Model for Hearing Loss
Res Sq [Preprint]. 2024 Apr 1:rs.3.rs-4096027. doi: 10.21203/rs.3.rs-4096027/v1.ABSTRACTHearing impairment arises from the loss of either type of cochlear sensory hair cells. Inner hair cells act as primary sound transducers, while outer hair cells enhance sound-induced vibrations within the organ of Corti. Established models, such as systemic administration of ototoxic aminoglycosides, yield inconsistent and variable hair cell death in mice. Overcoming this limitation, we developed a method involving surgical delivery of a hyperosmotic sisomicin solution into the posterior semicircular canal of adult mice. This procedure ...
Source: Cell Research - April 22, 2024 Category: Cytology Authors: Ayse Maraslioglu-Sperber Fabian Blanc Stefan Heller Nesrine Benkafadar Source Type: research
Retraction: Case report: A rare case of tumor-to-tumor metastasis: metastatic lobular breast carcinoma to clear cell renal cell carcinoma
Pathol Oncol Res. 2024 Apr 5;30:1611784. doi: 10.3389/pore.2024.1611784. eCollection 2024.ABSTRACT[This retracts the article DOI: 10.3389/pore.2023.1611204.].PMID:38645566 | PMC:PMC11027495 | DOI:10.3389/pore.2024.1611784 (Source: Cell Research)
Source: Cell Research - April 22, 2024 Category: Cytology Authors: Pathology and Oncology Research Editorial Office Source Type: research
Chronic exposure to Zearalenone leads to endometrial hyperplasia in CD-1 mice by altering the inflammatory markers
CONCLUSION: Our finding conclude that ZEA targets the uterus and cause inflammation due to increased levels of inflammatory cytokines and proliferation mediators, as well as systemic toxicity denoted by a strong binding affinity with serum proteins.PMID:38645625 | PMC:PMC11031408 | DOI:10.1093/toxres/tfae055 (Source: Cell Research)
Source: Cell Research - April 22, 2024 Category: Cytology Authors: Varsha Singh Payal Mandal Shweta Singh Chauhan Ishrat Jahan Saifi None Marhaba P V Sandeep Pankaj Jagdale Anjaneya Ayanur Kausar Mahmood Ansari Source Type: research
Basement Membrane Mimetic Hydrogel Cooperates with Rho-Associated Protein Kinase Inhibitor to Promote the Development of Acini-Like Salivary Gland Spheroids
Adv Nanobiomed Res. 2023 Nov;3(11):2300088. doi: 10.1002/anbr.202300088. Epub 2023 Oct 8.ABSTRACTSuccessful engineering of functional salivary glands necessitates the creation of cell-instructive environments for ex vivo expansion and lineage specification of primary human salivary gland stem cells (hS/PCs). Herein, basement membrane mimetic hydrogels were prepared using hyaluronic acid, cell adhesive peptides, and hyperbranched polyglycerol (HPG), with or without sulfate groups, to produce "hyperGel+" or "hyperGel", respectively. Differential scanning fluorescence experiments confirmed the ability of the sulphated HPG pre...
Source: Cell Research - April 22, 2024 Category: Cytology Authors: Eric W Fowler Robert L Witt Xinqiao Jia Source Type: research
Integrated Analysis Identified TGFBI as a Biomarker of Disease Severity and Prognosis Correlated with Immune Infiltrates in Patients with Sepsis
CONCLUSION: TGFBI warrants additional exploration as a promising biomarker for assessing illness severity and prognosis in patients with sepsis, considering its significant association with immunological and inflammatory responses in this condition.PMID:38645878 | PMC:PMC11027929 | DOI:10.2147/JIR.S456132 (Source: Cell Research)
Source: Cell Research - April 22, 2024 Category: Cytology Authors: Mingjie Shi Yue Wei Runmin Guo Fei Luo Source Type: research
Phosphoproteomic Analysis Identified Mutual Phosphorylation of FAK and Src as a Mechanism of Osimertinib Resistance in < em > EGFR < /em > -Mutant Lung Cancer
CONCLUSIONS: Phosphoproteomic analysis may help elucidate the mechanisms of resistance to molecular-targeted therapies in lung cancer. Mutual phosphorylation of FAK and Src is involved in osimertinib resistance. Thus, FAK and Src inhibition may be novel treatment strategies for osimertinib-resistant NSCLC.PMID:38646155 | PMC:PMC11031815 | DOI:10.1016/j.jtocrr.2024.100668 (Source: Cell Research)
Source: Cell Research - April 22, 2024 Category: Cytology Authors: Takehiro Tozuka Rintaro Noro Keisuke Yoshida Satoshi Takahashi Mariko Hirao Kuniko Matsuda Yasuhiro Kato Shinji Nakamichi Susumu Takeuchi Masaru Matsumoto Akihiko Miyanaga Shinobu Kunugi Kazufumi Honda Jun Adachi Masahiro Seike Source Type: research
Trem2 promotes foamy macrophage lipid uptake and survival in atherosclerosis
Nat Cardiovasc Res. 2023 Nov;2(11):1015-1031. doi: 10.1038/s44161-023-00354-3. Epub 2023 Oct 30.ABSTRACTAtherosclerosis is driven by the expansion of cholesterol-loaded 'foamy' macrophages in the arterial intima. Factors regulating foamy macrophage differentiation and survival in plaque remain poorly understood. Here we show, using trajectory analysis of integrated single-cell RNA sequencing data and a genome-wide CRISPR screen, that triggering receptor expressed on myeloid cells 2 (Trem2) is associated with foamy macrophage specification. Loss of Trem2 led to a reduced ability of foamy macrophages to take up oxidized low-...
Source: Cell Research - April 22, 2024 Category: Cytology Authors: Michael T Patterson Maria M Firulyova Yingzheng Xu Hannah Hillman Courtney Bishop Alisha Zhu Grant H Hickok Patricia R Schrank Christine E Ronayne Zakariya Caillot Gavin Fredrickson Ainsley E Kennedy Nisha Acharya Jaap G Neels Giulia Chinetti Xavier Revel Source Type: research
Inhibition of CDK7 mitigates doxorubicin cardiotoxicity and enhances anticancer efficacy
CONCLUSIONS: Activation of CDK7 is necessary for DOX-induced cardiomyocyte apoptosis and cardiomyopathy. Our findings uncover a novel proapoptotic role for CDK7 in cardiomyocytes. Moreover, this study suggests that inhibition of CDK7 attenuates DOX-induced cardiotoxicity, but augments the anticancer efficacy of DOX. Therefore, combined administration of CDK7 inhibitor and DOX may exhibit diminished cardiotoxicity but superior anticancer activity.PMID:38646672 | DOI:10.1093/cvr/cvae084 (Source: Cell Research)
Source: Cell Research - April 22, 2024 Category: Cytology Authors: Jingrui Chen Jing Wei Peng Xia Yuening Liu Mahder Dawit Belew Ryan Toohill Boyang Jason Wu Zhaokang Cheng Source Type: research
