Persistent Cytopenia After CD19 CAR T Therapy in Relapsed/Refractory DLBCL Patients Could Be a Predictor of Efficacy and Side Effects
Cell Transplant. 2024 Jan-Dec;33:9636897241247951. doi: 10.1177/09636897241247951.ABSTRACTHematological toxicity is a severe adverse event (AE) in anti-CD19 chimeric antigen receptor (CAR) T cell therapy for relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL). However, the pathophysiological mechanism underlying prolonged cytopenia and the relationship between persistent cytopenia, efficacy, and AEs after anti-CD19 CAR T cell therapy are unknown. Therefore, this study explored whether persistent cytopenia after anti-CD19 CAR T cell therapy in patients with R/R DLBCL can predict therapeutic efficacy and AEs. Thi...
Source: Cell Transplantation - April 23, 2024 Category: Cytology Authors: Jingyi Li Juan Mu Jia Wang Xin Li Qing Li Yili Jiang Rui Cui Qi Deng Source Type: research
From the Clinical to the Bench: Exploring the Insulin Modulation Effects of Tacrolimus and Belatacept
This study investigates whether the observed effects on PTD stem solely from CNI withdrawal or if belatacept influences PTD independently. The study assessed the impact of tacrolimus and belatacept on insulin secretion in MIN6 cells (a beta cell line) and rat islets. Tacrolimus and belatacept were administered to the cells and islets, followed by assessments of cell viability and insulin secretion. Tacrolimus impaired insulin secretion without affecting cell viability, while belatacept showed no detrimental effects on either parameter. These findings support clinical observations of improved HbA1c upon switching from tacro...
Source: Cell Transplantation - April 22, 2024 Category: Cytology Authors: Quentin Perrier C écile Cottet-Rouselle Marine de-Beaumont Johan Noble Sandrine Lablanche Source Type: research
Overcoming Methodological Challenges for Advancing Stem Cell Therapies in Parkinson's Disease
Cell Transplant. 2024 Jan-Dec;33:9636897241246355. doi: 10.1177/09636897241246355.ABSTRACTThe quest for new and improved therapies for Parkinson's disease (PD) remains of paramount importance, despite previous trial failures. There is a current debate regarding the potential of stem cell research as a therapeutic approach for PD. The studies of dopaminergic fetal stem cells for PD treatment, their design, and the results of the initial surgical placebo-controlled trials were reviewed in this study. Some of the fundamental methodological challenges and possible strategies to resolve them were proposed. In this article, we a...
Source: Cell Transplantation - April 18, 2024 Category: Cytology Authors: Stephen Polgar David I Finkelstein Leila Karimi Source Type: research
Overcoming Methodological Challenges for Advancing Stem Cell Therapies in Parkinson's Disease
Cell Transplant. 2024 Jan-Dec;33:9636897241246355. doi: 10.1177/09636897241246355.ABSTRACTThe quest for new and improved therapies for Parkinson's disease (PD) remains of paramount importance, despite previous trial failures. There is a current debate regarding the potential of stem cell research as a therapeutic approach for PD. The studies of dopaminergic fetal stem cells for PD treatment, their design, and the results of the initial surgical placebo-controlled trials were reviewed in this study. Some of the fundamental methodological challenges and possible strategies to resolve them were proposed. In this article, we a...
Source: Cell Transplantation - April 18, 2024 Category: Cytology Authors: Stephen Polgar David I Finkelstein Leila Karimi Source Type: research
Mechanism Exploration on the Immunoregulation of Allogeneic Heart Transplantation Rejection in Rats With Exosome miRNA and Proteins From Overexpressed IDO1 BMSCs
This study aims to elucidate the immune-related functional mechanisms of exosomes (Exos) derived from bone marrow-derived mesenchymal stem cells (BMSCs) overexpressing IDO1 in the context of allogeneic heart transplantation (HTx) rejection. A rat model of allogeneic HTx was established. Exos were extracted after transfection with oe-IDO1 and oe-NC from rat BMSCs. Exos were administered via the caudal vein for treatment. The survival of rats was analyzed, and reverse transcription qualitative PCR (RT-qPCR) and immunohistochemistry (IHC) were employed to detect the expression of related genes. Histopathological examination w...
Source: Cell Transplantation - April 17, 2024 Category: Cytology Authors: Rui Zheng Xinxin Wu Si Li Xinhao Chen Dan Yan Jigang He Source Type: research
Mechanism Exploration on the Immunoregulation of Allogeneic Heart Transplantation Rejection in Rats With Exosome miRNA and Proteins From Overexpressed IDO1 BMSCs
This study aims to elucidate the immune-related functional mechanisms of exosomes (Exos) derived from bone marrow-derived mesenchymal stem cells (BMSCs) overexpressing IDO1 in the context of allogeneic heart transplantation (HTx) rejection. A rat model of allogeneic HTx was established. Exos were extracted after transfection with oe-IDO1 and oe-NC from rat BMSCs. Exos were administered via the caudal vein for treatment. The survival of rats was analyzed, and reverse transcription qualitative PCR (RT-qPCR) and immunohistochemistry (IHC) were employed to detect the expression of related genes. Histopathological examination w...
Source: Cell Transplantation - April 17, 2024 Category: Cytology Authors: Rui Zheng Xinxin Wu Si Li Xinhao Chen Dan Yan Jigang He Source Type: research
Optimization of Xenografting Methods for Generating Human Skeletal Muscle in Mice
Cell Transplant. 2024 Jan-Dec;33:9636897241242624. doi: 10.1177/09636897241242624.ABSTRACTXenografts of human skeletal muscle generated in mice can be used to study muscle pathology and to test drugs designed to treat myopathies and muscular dystrophies for their efficacy and specificity in human tissue. We previously developed methods to generate mature human skeletal muscles in immunocompromised mice starting with human myogenic precursor cells (hMPCs) from healthy individuals and individuals with facioscapulohumeral muscular dystrophy (FSHD). Here, we examine a series of alternative treatments at each stage in order to ...
Source: Cell Transplantation - April 11, 2024 Category: Cytology Authors: Andrea O'Neill Anna Llach Martinez Amber L Mueller Weiliang Huang Anthony Accorsi Maureen A Kane David Eyerman Robert J Bloch Source Type: research
Increased Anti-Inflammatory Therapeutic Potential and Progenitor Marker Expression of Corneal Mesenchymal Stem Cells Cultured in an Optimized Propagation Medium
Cell Transplant. 2024 Jan-Dec;33:9636897241241992. doi: 10.1177/09636897241241992.ABSTRACTThere is a huge unmet need for new treatment modalities for ocular surface inflammatory disorders (OSIDs) such as dry eye disease and meibomian gland dysfunction. Mesenchymal stem cell therapies may hold the answer due to their potent immunomodulatory properties, low immunogenicity, and ability to modulate both the innate and adaptive immune response. MSC-like cells that can be isolated from the corneal stroma (C-MSCs) offer a potential new treatment strategy; however, an optimized culture medium needs to be developed to produce the i...
Source: Cell Transplantation - April 11, 2024 Category: Cytology Authors: Andrew Hopkinson Maria Notara Claus Cursiefen Laura E Sidney Source Type: research
Optimization of Xenografting Methods for Generating Human Skeletal Muscle in Mice
Cell Transplant. 2024 Jan-Dec;33:9636897241242624. doi: 10.1177/09636897241242624.ABSTRACTXenografts of human skeletal muscle generated in mice can be used to study muscle pathology and to test drugs designed to treat myopathies and muscular dystrophies for their efficacy and specificity in human tissue. We previously developed methods to generate mature human skeletal muscles in immunocompromised mice starting with human myogenic precursor cells (hMPCs) from healthy individuals and individuals with facioscapulohumeral muscular dystrophy (FSHD). Here, we examine a series of alternative treatments at each stage in order to ...
Source: Cell Transplantation - April 11, 2024 Category: Cytology Authors: Andrea O'Neill Anna Llach Martinez Amber L Mueller Weiliang Huang Anthony Accorsi Maureen A Kane David Eyerman Robert J Bloch Source Type: research
Increased Anti-Inflammatory Therapeutic Potential and Progenitor Marker Expression of Corneal Mesenchymal Stem Cells Cultured in an Optimized Propagation Medium
Cell Transplant. 2024 Jan-Dec;33:9636897241241992. doi: 10.1177/09636897241241992.ABSTRACTThere is a huge unmet need for new treatment modalities for ocular surface inflammatory disorders (OSIDs) such as dry eye disease and meibomian gland dysfunction. Mesenchymal stem cell therapies may hold the answer due to their potent immunomodulatory properties, low immunogenicity, and ability to modulate both the innate and adaptive immune response. MSC-like cells that can be isolated from the corneal stroma (C-MSCs) offer a potential new treatment strategy; however, an optimized culture medium needs to be developed to produce the i...
Source: Cell Transplantation - April 11, 2024 Category: Cytology Authors: Andrew Hopkinson Maria Notara Claus Cursiefen Laura E Sidney Source Type: research
Optimization of Xenografting Methods for Generating Human Skeletal Muscle in Mice
Cell Transplant. 2024 Jan-Dec;33:9636897241242624. doi: 10.1177/09636897241242624.ABSTRACTXenografts of human skeletal muscle generated in mice can be used to study muscle pathology and to test drugs designed to treat myopathies and muscular dystrophies for their efficacy and specificity in human tissue. We previously developed methods to generate mature human skeletal muscles in immunocompromised mice starting with human myogenic precursor cells (hMPCs) from healthy individuals and individuals with facioscapulohumeral muscular dystrophy (FSHD). Here, we examine a series of alternative treatments at each stage in order to ...
Source: Cell Transplantation - April 11, 2024 Category: Cytology Authors: Andrea O'Neill Anna Llach Martinez Amber L Mueller Weiliang Huang Anthony Accorsi Maureen A Kane David Eyerman Robert J Bloch Source Type: research
Increased Anti-Inflammatory Therapeutic Potential and Progenitor Marker Expression of Corneal Mesenchymal Stem Cells Cultured in an Optimized Propagation Medium
Cell Transplant. 2024 Jan-Dec;33:9636897241241992. doi: 10.1177/09636897241241992.ABSTRACTThere is a huge unmet need for new treatment modalities for ocular surface inflammatory disorders (OSIDs) such as dry eye disease and meibomian gland dysfunction. Mesenchymal stem cell therapies may hold the answer due to their potent immunomodulatory properties, low immunogenicity, and ability to modulate both the innate and adaptive immune response. MSC-like cells that can be isolated from the corneal stroma (C-MSCs) offer a potential new treatment strategy; however, an optimized culture medium needs to be developed to produce the i...
Source: Cell Transplantation - April 11, 2024 Category: Cytology Authors: Andrew Hopkinson Maria Notara Claus Cursiefen Laura E Sidney Source Type: research
Optimization of Xenografting Methods for Generating Human Skeletal Muscle in Mice
Cell Transplant. 2024 Jan-Dec;33:9636897241242624. doi: 10.1177/09636897241242624.ABSTRACTXenografts of human skeletal muscle generated in mice can be used to study muscle pathology and to test drugs designed to treat myopathies and muscular dystrophies for their efficacy and specificity in human tissue. We previously developed methods to generate mature human skeletal muscles in immunocompromised mice starting with human myogenic precursor cells (hMPCs) from healthy individuals and individuals with facioscapulohumeral muscular dystrophy (FSHD). Here, we examine a series of alternative treatments at each stage in order to ...
Source: Cell Transplantation - April 11, 2024 Category: Cytology Authors: Andrea O'Neill Anna Llach Martinez Amber L Mueller Weiliang Huang Anthony Accorsi Maureen A Kane David Eyerman Robert J Bloch Source Type: research
Increased Anti-Inflammatory Therapeutic Potential and Progenitor Marker Expression of Corneal Mesenchymal Stem Cells Cultured in an Optimized Propagation Medium
Cell Transplant. 2024 Jan-Dec;33:9636897241241992. doi: 10.1177/09636897241241992.ABSTRACTThere is a huge unmet need for new treatment modalities for ocular surface inflammatory disorders (OSIDs) such as dry eye disease and meibomian gland dysfunction. Mesenchymal stem cell therapies may hold the answer due to their potent immunomodulatory properties, low immunogenicity, and ability to modulate both the innate and adaptive immune response. MSC-like cells that can be isolated from the corneal stroma (C-MSCs) offer a potential new treatment strategy; however, an optimized culture medium needs to be developed to produce the i...
Source: Cell Transplantation - April 11, 2024 Category: Cytology Authors: Andrew Hopkinson Maria Notara Claus Cursiefen Laura E Sidney Source Type: research
Optimization of Xenografting Methods for Generating Human Skeletal Muscle in Mice
Cell Transplant. 2024 Jan-Dec;33:9636897241242624. doi: 10.1177/09636897241242624.ABSTRACTXenografts of human skeletal muscle generated in mice can be used to study muscle pathology and to test drugs designed to treat myopathies and muscular dystrophies for their efficacy and specificity in human tissue. We previously developed methods to generate mature human skeletal muscles in immunocompromised mice starting with human myogenic precursor cells (hMPCs) from healthy individuals and individuals with facioscapulohumeral muscular dystrophy (FSHD). Here, we examine a series of alternative treatments at each stage in order to ...
Source: Cell Transplantation - April 11, 2024 Category: Cytology Authors: Andrea O'Neill Anna Llach Martinez Amber L Mueller Weiliang Huang Anthony Accorsi Maureen A Kane David Eyerman Robert J Bloch Source Type: research
