Expression of Toll-Like Receptors in the Lung Tissue of Mouse Fetuses Generated by in vitro Embryo Culture and Embryo Transfer
Mouse fetuses generated by in vitro embryo culture and embryo transfer exhibit impaired lung development, altered composition of pulmonary epithelial cells associated with downregulation of several genes involved in lung development and toll-like receptor (TLR) signaling pathway. The aims of the present study were to determine the expression of all TLRs and to examine if the expression of TLRs, along with genes involved in TLR signaling pathway, is altered in the lung tissue of mouse fetuses generated through embryo culture and embryo transfer. Two experimental (EGs) and one control (CG) group were included in the study. E...
Source: Cells Tissues Organs - April 27, 2023 Category: Cytology Source Type: research
Developing Fibrous Biomaterials to Modulate Epithelial to Mesenchymal Transition
Despite their critical roles in tissue repair and pathological processes such as fibrosis, tumor invasion and metastasis, the origins of mesenchymal cells remain poorly understood. Among the likely routes, epithelial to mesenchymal transitions (EMTs) emerge as important source of these cells. EMTs manifests themselves as a phenotypic transition in terminally differentiated epithelial cells into mesenchymal cells which is closely related to embryogenesis and organ development as well as in chronically inflamed tissues and neoplasia. There exists a potential for successful engineering of biomimetic environments that closely ...
Source: Cells Tissues Organs - April 18, 2023 Category: Cytology Source Type: research
Emergence of Spatial Scales and Macroscopic Tissue Dynamics in Active Epithelial Monolayers
Migrating cells in tissues are often known to exhibit collective swirling movements. In this paper, we develop an active vertex model with polarity dynamics based on contact inhibition of locomotion (CIL). We show that under this dynamics, the cells form steady-state vortices in velocity, polarity, and cell stress with length scales that depend on polarity alignment rate ( ζ), self-motility (v0), and cell-cell bond tension ( λ). When the ratio λ/v0 becomes larger, the tissue reaches a near jamming state because of the inability of the cells to exchange their neighbors, and the length scale associated with tissue kinemat...
Source: Cells Tissues Organs - April 12, 2023 Category: Cytology Source Type: research
A Tunable Calcium Phosphate Coating to Drive in vivo Osseointegration of Composite Engineered Tissues
This study also demonstrated that the use of SBF-based HA coatings can promote higher levels of osteogenesis in vivo. Finally, when incorporated as the endplate region of a larger tissue-engineered intervertebral disc replacement, HA coating did not induce mineralization in or promote cell migration out of neighboring biomaterials. Overall, these results verified tunable biomimetic HA coatings as a promising biomaterial modification to promote discrete regions of mineralization within composite engineered tissues.Cells Tissues Organs (Source: Cells Tissues Organs)
Source: Cells Tissues Organs - March 24, 2023 Category: Cytology Source Type: research
RETRACTED - RETRACTED - Retraction Statement
Cells Tissues Organs (Source: Cells Tissues Organs)
Source: Cells Tissues Organs - March 10, 2023 Category: Cytology Source Type: research
RETRACTED - Retraction Statement
Cells Tissues Organs (Source: Cells Tissues Organs)
Source: Cells Tissues Organs - March 10, 2023 Category: Cytology Source Type: research
Retraction Statement
Cells Tissues Organs (Source: Cells Tissues Organs)
Source: Cells Tissues Organs - March 10, 2023 Category: Cytology Source Type: research
Prelims
Cells Tissues Organs 2023;212:1 –4 (Source: Cells Tissues Organs)
Source: Cells Tissues Organs - March 9, 2023 Category: Cytology Source Type: research
Author Index
Cells Tissues Organs 2023;212:124 (Source: Cells Tissues Organs)
Source: Cells Tissues Organs - March 9, 2023 Category: Cytology Source Type: research
Differentiation of myoblasts in culture: focus on serum and GABA
There are many facts about the possible role of gamma-aminobutyric acid (GABA) in the development and differentiation of cells not only in nervous but also in muscle tissue. In the present study a primary culture of rat skeletal muscle myocytes was used to evaluate the correlation between the content of GABA in the cytoplasm and the processes of myocyte division and their fusion into myotubes.The effect of exogenous GABA on the processes of culture development was also estimated. Since the classical protocol for working with myocyte cultures involves the use of fetal bovine serum (FBS) to stimulate cell division (growth me...
Source: Cells Tissues Organs - March 3, 2023 Category: Cytology Source Type: research
