Decoding epitranscriptomic regulation of viral infection: mapping of RNA N < sup > 6 < /sup > -methyladenosine by advanced sequencing technologies
Cell Mol Biol Lett. 2024 Mar 27;29(1):42. doi: 10.1186/s11658-024-00564-y.ABSTRACTElucidating the intricate interactions between viral pathogens and host cellular machinery during infection is paramount for understanding pathogenic mechanisms and identifying potential therapeutic targets. The RNA modification N6-methyladenosine (m6A) has emerged as a significant factor influencing the trajectory of viral infections. Hence, the precise and quantitative mapping of m6A modifications in both host and viral RNA is pivotal to understanding its role during viral infection. With the rapid advancement of sequencing technologies, sc...
Source: Cellular and Molecular Biology Letters - March 28, 2024 Category: Biochemistry Authors: Xiangdong Fan Yitong Zhang Ruiying Guo Kuo Yue Guy Smagghe Yongyue Lu Luoluo Wang Source Type: research

Oncogenic circ-SLC16A1 promotes progression of non-small cell lung cancer via regulation of the miR-1287-5p/profilin 2 axis
CONCLUSIONS: Collectively, these findings show that miR-1287-5p/PFN2 signaling was associated with downregulation of circ-SLC16A1 and reduced invasion and proliferation of NSCLC cells. So, circ-SLC16A1 is identified as a mediator of multiple pro-oncogenic signaling pathways in NSCLC and can be targeted to suppress tumor progression.PMID:38539084 | DOI:10.1186/s11658-024-00549-x (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - March 28, 2024 Category: Biochemistry Authors: Mingming Jin Tailei Yuan Kaisai Tian Jingjing Li Qingqing Huang Yongbin Chi Gang Huang Source Type: research

Emerging roles of prominin-1 (CD133) in the dynamics of plasma membrane architecture and cell signaling pathways in health and disease
Cell Mol Biol Lett. 2024 Mar 26;29(1):41. doi: 10.1186/s11658-024-00554-0.ABSTRACTProminin-1 (CD133) is a cholesterol-binding membrane glycoprotein selectively associated with highly curved and prominent membrane structures. It is widely recognized as an antigenic marker of stem cells and cancer stem cells and is frequently used to isolate them from biological and clinical samples. Recent progress in understanding various aspects of CD133 biology in different cell types has revealed the involvement of CD133 in the architecture and dynamics of plasma membrane protrusions, such as microvilli and cilia, including the release ...
Source: Cellular and Molecular Biology Letters - March 27, 2024 Category: Biochemistry Authors: Petr Pleska č Christine A Fargeas Renata Veselska Denis Corbeil Jan Skoda Source Type: research

Emerging roles of prominin-1 (CD133) in the dynamics of plasma membrane architecture and cell signaling pathways in health and disease
Cell Mol Biol Lett. 2024 Mar 26;29(1):41. doi: 10.1186/s11658-024-00554-0.ABSTRACTProminin-1 (CD133) is a cholesterol-binding membrane glycoprotein selectively associated with highly curved and prominent membrane structures. It is widely recognized as an antigenic marker of stem cells and cancer stem cells and is frequently used to isolate them from biological and clinical samples. Recent progress in understanding various aspects of CD133 biology in different cell types has revealed the involvement of CD133 in the architecture and dynamics of plasma membrane protrusions, such as microvilli and cilia, including the release ...
Source: Cellular and Molecular Biology Letters - March 27, 2024 Category: Biochemistry Authors: Petr Pleska č Christine A Fargeas Renata Veselska Denis Corbeil Jan Skoda Source Type: research

Role of ferroptosis and ferroptosis-related long non'coding RNA in breast cancer
Cell Mol Biol Lett. 2024 Mar 26;29(1):40. doi: 10.1186/s11658-024-00560-2.ABSTRACTFerroptosis, a therapeutic strategy for tumours, is a regulated cell death characterised by the increased accumulation of iron-dependent lipid peroxides (LPO). Tumour-associated long non-coding RNAs (lncRNAs), when combined with traditional anti-cancer medicines or radiotherapy, can improve efficacy and decrease mortality in cancer. Investigating the role of ferroptosis-related lncRNAs may help strategise new therapeutic options for breast cancer (BC). Herein, we briefly discuss the genes and pathways of ferroptosis involved in iron and react...
Source: Cellular and Molecular Biology Letters - March 26, 2024 Category: Biochemistry Authors: Shasha Xiang Wen Yan Xing Ren Jianbo Feng Xuyu Zu Source Type: research

IGF2BP3 prevent HMGB1 mRNA decay in bladder cancer and development
CONCLUSIONS: Our present study sheds light on the genetic and epigenetic mechanisms governing IGF2BP3 expression, underscoring the critical involvement of the IGF2BP3-HMGB1 axis in driving bladder cancer progression. Additionally, it advocates for the investigation of inhibiting IGF2BP3-HMGB1 as a viable therapeutic approach for treating bladder cancer.PMID:38504159 | PMC:PMC10949762 | DOI:10.1186/s11658-024-00545-1 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - March 20, 2024 Category: Biochemistry Authors: Lei Lv Qinqin Wei Jianxiao Zhang Yitong Dong Zhenglei Shan Na Chang Ye Zhao Po Bian Qiyi Yi Source Type: research

IGF2BP3 prevent HMGB1 mRNA decay in bladder cancer and development
CONCLUSIONS: Our present study sheds light on the genetic and epigenetic mechanisms governing IGF2BP3 expression, underscoring the critical involvement of the IGF2BP3-HMGB1 axis in driving bladder cancer progression. Additionally, it advocates for the investigation of inhibiting IGF2BP3-HMGB1 as a viable therapeutic approach for treating bladder cancer.PMID:38504159 | PMC:PMC10949762 | DOI:10.1186/s11658-024-00545-1 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - March 20, 2024 Category: Biochemistry Authors: Lei Lv Qinqin Wei Jianxiao Zhang Yitong Dong Zhenglei Shan Na Chang Ye Zhao Po Bian Qiyi Yi Source Type: research

IGF2BP3 prevent HMGB1 mRNA decay in bladder cancer and development
CONCLUSIONS: Our present study sheds light on the genetic and epigenetic mechanisms governing IGF2BP3 expression, underscoring the critical involvement of the IGF2BP3-HMGB1 axis in driving bladder cancer progression. Additionally, it advocates for the investigation of inhibiting IGF2BP3-HMGB1 as a viable therapeutic approach for treating bladder cancer.PMID:38504159 | PMC:PMC10949762 | DOI:10.1186/s11658-024-00545-1 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - March 20, 2024 Category: Biochemistry Authors: Lei Lv Qinqin Wei Jianxiao Zhang Yitong Dong Zhenglei Shan Na Chang Ye Zhao Po Bian Qiyi Yi Source Type: research

IGF2BP3 prevent HMGB1 mRNA decay in bladder cancer and development
CONCLUSIONS: Our present study sheds light on the genetic and epigenetic mechanisms governing IGF2BP3 expression, underscoring the critical involvement of the IGF2BP3-HMGB1 axis in driving bladder cancer progression. Additionally, it advocates for the investigation of inhibiting IGF2BP3-HMGB1 as a viable therapeutic approach for treating bladder cancer.PMID:38504159 | DOI:10.1186/s11658-024-00545-1 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - March 20, 2024 Category: Biochemistry Authors: Lei Lv Qinqin Wei Jianxiao Zhang Yitong Dong Zhenglei Shan Na Chang Ye Zhao Po Bian Qiyi Yi Source Type: research

IGF2BP3 prevent HMGB1 mRNA decay in bladder cancer and development
CONCLUSIONS: Our present study sheds light on the genetic and epigenetic mechanisms governing IGF2BP3 expression, underscoring the critical involvement of the IGF2BP3-HMGB1 axis in driving bladder cancer progression. Additionally, it advocates for the investigation of inhibiting IGF2BP3-HMGB1 as a viable therapeutic approach for treating bladder cancer.PMID:38504159 | DOI:10.1186/s11658-024-00545-1 (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - March 20, 2024 Category: Biochemistry Authors: Lei Lv Qinqin Wei Jianxiao Zhang Yitong Dong Zhenglei Shan Na Chang Ye Zhao Po Bian Qiyi Yi Source Type: research

Uremic toxins mediate kidney diseases: the role of aryl hydrocarbon receptor
Cell Mol Biol Lett. 2024 Mar 15;29(1):38. doi: 10.1186/s11658-024-00550-4.ABSTRACTAryl hydrocarbon receptor (AhR) was originally identified as an environmental sensor that responds to pollutants. Subsequent research has revealed that AhR recognizes multiple exogenous and endogenous molecules, including uremic toxins retained in the body due to the decline in renal function. Therefore, AhR is also considered to be a uremic toxin receptor. As a ligand-activated transcriptional factor, the activation of AhR is involved in cell differentiation and senescence, lipid metabolism and fibrogenesis. The accumulation of uremic toxins...
Source: Cellular and Molecular Biology Letters - March 16, 2024 Category: Biochemistry Authors: Hongyan Xie Ninghao Yang Chen Yu Limin Lu Source Type: research

Uremic toxins mediate kidney diseases: the role of aryl hydrocarbon receptor
Cell Mol Biol Lett. 2024 Mar 15;29(1):38. doi: 10.1186/s11658-024-00550-4.ABSTRACTAryl hydrocarbon receptor (AhR) was originally identified as an environmental sensor that responds to pollutants. Subsequent research has revealed that AhR recognizes multiple exogenous and endogenous molecules, including uremic toxins retained in the body due to the decline in renal function. Therefore, AhR is also considered to be a uremic toxin receptor. As a ligand-activated transcriptional factor, the activation of AhR is involved in cell differentiation and senescence, lipid metabolism and fibrogenesis. The accumulation of uremic toxins...
Source: Cellular and Molecular Biology Letters - March 16, 2024 Category: Biochemistry Authors: Hongyan Xie Ninghao Yang Chen Yu Limin Lu Source Type: research

Uremic toxins mediate kidney diseases: the role of aryl hydrocarbon receptor
Cell Mol Biol Lett. 2024 Mar 15;29(1):38. doi: 10.1186/s11658-024-00550-4.ABSTRACTAryl hydrocarbon receptor (AhR) was originally identified as an environmental sensor that responds to pollutants. Subsequent research has revealed that AhR recognizes multiple exogenous and endogenous molecules, including uremic toxins retained in the body due to the decline in renal function. Therefore, AhR is also considered to be a uremic toxin receptor. As a ligand-activated transcriptional factor, the activation of AhR is involved in cell differentiation and senescence, lipid metabolism and fibrogenesis. The accumulation of uremic toxins...
Source: Cellular and Molecular Biology Letters - March 16, 2024 Category: Biochemistry Authors: Hongyan Xie Ninghao Yang Chen Yu Limin Lu Source Type: research

Uremic toxins mediate kidney diseases: the role of aryl hydrocarbon receptor
Cell Mol Biol Lett. 2024 Mar 15;29(1):38. doi: 10.1186/s11658-024-00550-4.ABSTRACTAryl hydrocarbon receptor (AhR) was originally identified as an environmental sensor that responds to pollutants. Subsequent research has revealed that AhR recognizes multiple exogenous and endogenous molecules, including uremic toxins retained in the body due to the decline in renal function. Therefore, AhR is also considered to be a uremic toxin receptor. As a ligand-activated transcriptional factor, the activation of AhR is involved in cell differentiation and senescence, lipid metabolism and fibrogenesis. The accumulation of uremic toxins...
Source: Cellular and Molecular Biology Letters - March 16, 2024 Category: Biochemistry Authors: Hongyan Xie Ninghao Yang Chen Yu Limin Lu Source Type: research

Obesity-induced downregulation of miR-192 exacerbates lipopolysaccharide-induced acute lung injury by promoting macrophage activation
CONCLUSIONS: Our study indicates that obesity-induced downregulation of miR-192 expression exacerbates LPS-induced ALI by promoting macrophage activation. Targeting macrophages and miR-192 may provide new therapeutic avenues for obesity-associated ALI.PMID:38486141 | PMC:PMC10938800 | DOI:10.1186/s11658-024-00558-w (Source: Cellular and Molecular Biology Letters)
Source: Cellular and Molecular Biology Letters - March 15, 2024 Category: Biochemistry Authors: Siqi Wu Wenjing Tang Ling Liu Ke Wei Yin Tang Jingyue Ma Hongbin Li Yichan Ao Source Type: research