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Vascular mimicry as a facilitator of melanoma brain metastasis
Cell Mol Life Sci. 2024 Apr 18;81(1):188. doi: 10.1007/s00018-024-05217-z.ABSTRACTMelanoma has the highest propensity among solid tumors to metastasize to the brain. Melanoma brain metastases (MBM) are a leading cause of death in melanoma and affect 40-60% of patients with late-stage disease. Therefore, uncovering the molecular mechanisms behind MBM is necessary to enhance therapeutic interventions. Vascular mimicry (VM) is a form of neovascularization linked to invasion, increased risk of metastasis, and poor prognosis in many tumor types, but its significance in MBM remains poorly understood. We found that VM density is ...
Source: Cellular and Molecular Life Sciences : CMLS - April 18, 2024 Category: Cytology Authors: Olivia K Provance Victor O Oria Thuy T Tran Jasmine I Caulfield Christopher R Zito Adam Aguirre-Ducler Kurt A Schalper Harriet M Kluger Lucia B Jilaveanu Source Type: research

Role of transient receptor potential ankyrin 1 in idiopathic pulmonary fibrosis: modulation of M2 macrophage polarization
This study investigated the role of transient receptor potential ankyrin 1 (TRPA1) channels in regulating M2 macrophage polarization in IPF progression, potentially offering novel therapeutic targets. Using a bleomycin-induced pulmonary fibrosis model in C57BL/6J mice, we assessed the therapeutic potential of the TRPA1 inhibitor HC-030031. TRPA1 upregulation was observed in fibrotic lungs, correlating with worsened lung function and reduced survival. TRPA1 inhibition mitigated fibrosis severity, evidenced by decreased collagen deposition and restored lung tissue stiffness. Furthermore, TRPA1 blockade reversed aberrant M2 m...
Source: Cellular and Molecular Life Sciences : CMLS - April 18, 2024 Category: Cytology Authors: Yi Yang Zhenyu Xiao Weijie Yang Yangyang Sun Xin Sui Xueyang Lin Xinyi Yang Zhenghao Bao Ziqi Cui Yingkai Ma Weidong Li Shengran Wang Jun Yang Yongan Wang Yuan Luo Source Type: research

The impact of nanomaterials on autophagy across health and disease conditions
Cell Mol Life Sci. 2024 Apr 17;81(1):184. doi: 10.1007/s00018-024-05199-y.ABSTRACTAutophagy, a catabolic process integral to cellular homeostasis, is constitutively active under physiological and stress conditions. The role of autophagy as a cellular defense response becomes particularly evident upon exposure to nanomaterials (NMs), especially environmental nanoparticles (NPs) and nanoplastics (nPs). This has positioned autophagy modulation at the forefront of nanotechnology-based therapeutic interventions. While NMs can exploit autophagy to enhance therapeutic outcomes, they can also trigger it as a pro-survival response ...
Source: Cellular and Molecular Life Sciences : CMLS - April 17, 2024 Category: Cytology Authors: Ida Florance Marco Cordani Parya Pashootan Mohammad Amin Moosavi Ali Zarrabi Natarajan Chandrasekaran Source Type: research

RUNX transcription factors are essential in maintaining epididymal epithelial differentiation
Cell Mol Life Sci. 2024 Apr 17;81(1):183. doi: 10.1007/s00018-024-05211-5.ABSTRACTApart from the androgen receptor, transcription factors (TFs) that are required for the development and formation of the different segments of the epididymis have remained unknown. We identified TF families expressed in the developing epididymides, of which many showed segment specificity. From these TFs, down-regulation of runt related transcription factors (RUNXs) 1 and 2 expression coincides with epithelial regression in Dicer1 cKO mice. Concomitant deletion of both Runx1 and Runx2 in a mouse epididymal epithelial cell line affected cell m...
Source: Cellular and Molecular Life Sciences : CMLS - April 17, 2024 Category: Cytology Authors: Mervi Toriseva Ida Bj örkgren Arttu Junnila Arfa Mehmood Jesse Mattsson Inka Raimoranta Bongki Kim Asta Laiho Matthias Nees Laura Elo Matti Poutanen Sylvie Breton Petra Sipil ä Source Type: research

When DNA-damage responses meet innate and adaptive immunity
This study examines the most recent developments in the interaction between DDR elements and immunological responses. The DDR network's immune modulators' dual roles may offer new perspectives on treating infectious disorders linked to DNA damage, including cancer, and on the development of target immunotherapy.PMID:38630271 | PMC:PMC11023972 | DOI:10.1007/s00018-024-05214-2 (Source: Cellular and Molecular Life Sciences : CMLS)
Source: Cellular and Molecular Life Sciences : CMLS - April 17, 2024 Category: Cytology Authors: Jie Tong Jiangwei Song Wuchao Zhang Jingbo Zhai Qingli Guan Huiqing Wang Gentao Liu Chunfu Zheng Source Type: research

Dodecyl creatine ester therapy: from promise to reality
Cell Mol Life Sci. 2024 Apr 17;81(1):186. doi: 10.1007/s00018-024-05218-y.ABSTRACTPathogenic variants in SLC6A8, the gene which encodes creatine transporter SLC6A8, prevent creatine uptake in the brain and result in a variable degree of intellectual disability, behavioral disorders (e.g., autism spectrum disorder), epilepsy, and severe speech and language delay. There are no treatments to improve neurodevelopmental outcomes for creatine transporter deficiency (CTD). In this spotlight, we summarize recent advances in innovative molecules to treat CTD, with a focus on dodecyl creatine ester, the most promising drug candidate...
Source: Cellular and Molecular Life Sciences : CMLS - April 17, 2024 Category: Cytology Authors: Alo ïse Mabondzo Jiddeke van de Kamp Saadet Mercimek-Andrews Source Type: research

When DNA-damage responses meet innate and adaptive immunity
This study examines the most recent developments in the interaction between DDR elements and immunological responses. The DDR network's immune modulators' dual roles may offer new perspectives on treating infectious disorders linked to DNA damage, including cancer, and on the development of target immunotherapy.PMID:38630271 | DOI:10.1007/s00018-024-05214-2 (Source: Cellular and Molecular Life Sciences : CMLS)
Source: Cellular and Molecular Life Sciences : CMLS - April 17, 2024 Category: Cytology Authors: Jie Tong Jiangwei Song Wuchao Zhang Jingbo Zhai Qingli Guan Huiqing Wang Gentao Liu Chunfu Zheng Source Type: research

Linc-NSC affects cell differentiation, apoptosis and proliferation in mouse neural stem cells and embryonic stem cells in vitro and in vivo
CONCLUSIONS: Our analyses demonstrated that linc-NSC, a promising gene-edited target, may promote the differentiation of mouse NSCs and inhibit tumorigenesis in mouse ESCs. The knockdown of linc-NSC inhibited the apoptosis in NSCs both in vitro and in vivo, and prevented tumor formation, revealing a new dimension into the effect of lncRNA on low survival NSCs and providing a prospective gene manipulation target prior to transplantation. In parallel, the overexpression of linc-NSC induced apoptosis in ESCs both in vitro and in vivo and attenuated the tumorigenicity of ESCs in vivo, but did not completely prevent tumor forma...
Source: Cellular and Molecular Life Sciences : CMLS - April 14, 2024 Category: Cytology Authors: Lili Guo Dan Zou Wenqiao Qiu Fan Fei Lihua Chen Wenjin Chen Huan Xiong Xinda Li Yangyang Wang Mingjun Gao Jianwei Zhu Jin Zhang Yunsen He Mou Gao Ruxiang Xu Source Type: research

Identification of the role of DAB2 and CXCL8 in uterine spiral artery remodeling in early-onset preeclampsia
Cell Mol Life Sci. 2024 Apr 13;81(1):180. doi: 10.1007/s00018-024-05212-4.ABSTRACTAberrant remodeling of uterine spiral arteries (SPA) is strongly associated with the pathogenesis of early-onset preeclampsia (EOPE). However, the complexities of SPA transformation remain inadequately understood. We conducted a single-cell RNA sequencing analysis of whole placental tissues derived from patients with EOPE and their corresponding controls, identified DAB2 as a key gene of interest and explored the mechanism underlying the communication between Extravillous trophoblast cells (EVTs) and decidual vascular smooth muscle cells (dVS...
Source: Cellular and Molecular Life Sciences : CMLS - April 13, 2024 Category: Cytology Authors: Yu Liu Lili Du Shifeng Gu Jingying Liang Minshan Huang Lijun Huang Siying Lai Shuang Zhang Zhaowei Tu Wei Sun Dunjin Chen Jingsi Chen Source Type: research

Functional myelin in cognition and neurodevelopmental disorders
Cell Mol Life Sci. 2024 Apr 13;81(1):181. doi: 10.1007/s00018-024-05222-2.ABSTRACTIn vertebrates, oligodendrocytes (OLs) are glial cells of the central nervous system (CNS) responsible for the formation of the myelin sheath that surrounds the axons of neurons. The myelin sheath plays a crucial role in the transmission of neuronal information by promoting the rapid saltatory conduction of action potentials and providing neurons with structural and metabolic support. Saltatory conduction, first described in the peripheral nervous system (PNS), is now generally recognized as a universal evolutionary innovation to respond quic...
Source: Cellular and Molecular Life Sciences : CMLS - April 13, 2024 Category: Cytology Authors: Hasni Khelfaoui Cristobal Ibaceta-Gonzalez Maria Cecilia Angulo Source Type: research

Epigenomic insights into common human disease pathology
Cell Mol Life Sci. 2024 Apr 11;81(1):178. doi: 10.1007/s00018-024-05206-2.ABSTRACTThe epigenome-the chemical modifications and chromatin-related packaging of the genome-enables the same genetic template to be activated or repressed in different cellular settings. This multi-layered mechanism facilitates cell-type specific function by setting the local sequence and 3D interactive activity level. Gene transcription is further modulated through the interplay with transcription factors and co-regulators. The human body requires this epigenomic apparatus to be precisely installed throughout development and then adequately maint...
Source: Cellular and Molecular Life Sciences : CMLS - April 11, 2024 Category: Cytology Authors: Christopher G Bell Source Type: research