Cellular and Molecular Neurobiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Neutrophil Extracellular Traps Regulate Surgical Brain Injury by Activating the cGAS-STING Pathway
In this study, we found that neutrophil extracellular traps (NETs) were present in the circulation and brain tissues of rats after SBI, which promoted neuroinflammation, cerebral edema, neuronal cell death, and aggravated neurological dysfunction. Inhibition of NETs formation by peptidylarginine deiminase (PAD) inhibitor or disruption of NETs with deoxyribonuclease I (DNase I) attenuated SBI-induced damages and improved the recovery of neurological function. We show that SBI triggered the activation of cyclic guanosine monophosphate-adenosine monophosphate synthase stimulator of interferon genes (cGAS-STING), and that inhi...
Source: Cellular and Molecular Neurobiology - April 18, 2024 Category: Cytology Authors: Bingbing Li Lixia Xu Zhengang Wang Qi Shi Yang Cui Weijia Fan Qiaoli Wu Xiaoguang Tong Hua Yan Source Type: research

FoxG1 as a Potential Therapeutic Target for Alzheimer's Disease: Modulating NLRP3 Inflammasome via AMPK/mTOR Autophagy Pathway
Cell Mol Neurobiol. 2024 Apr 17;44(1):35. doi: 10.1007/s10571-024-01467-4.ABSTRACTAn increasing body of research suggests that promoting microglial autophagy hinders the neuroinflammation initiated though the NLRP3 inflammasome activation in Alzheimer's disease (AD). The function of FoxG1, a crucial transcription factor involved in cell survival by regulating mitochondrial function, remains unknown during the AD process and neuroinflammation occurs. In the present study, we firstly found that Aβ peptides induced AD-like neuroinflammation upregulation and downregulated the level of autophagy. Following low-dose Aβ25-35 st...
Source: Cellular and Molecular Neurobiology - April 17, 2024 Category: Cytology Authors: Qi Yun Si-Fei Ma Wei-Ning Zhang Meng Gu Jia Wang Source Type: research

TIMP-3 Alleviates White Matter Injury After Subarachnoid Hemorrhage in Mice by Promoting Oligodendrocyte Precursor Cell Maturation
This study was designed to investigate the effect of tissue inhibitor of metalloproteinase-3 (TIMP-3) for OPC differentiation and maturation. PDGFRβret/ret and wild-type C57B6J male mice were used to construct a mouse model of SAH via endovascular perforation in this study. Mice were also treated with vehicle, TIMP-3 RNAi or TIMP-3 RNAi + TIMP-3 after SAH. The effect of TIMP-3 on the differentiation and maturation of OPCs was determined using behavioral score, ELISA, transmission electron microscopy, immunofluorescence staining and cell culture. We found that TIMP-3 was secreted mainly by pericytes and that SAH and TIMP-3...
Source: Cellular and Molecular Neurobiology - April 16, 2024 Category: Cytology Authors: Peiwen Guo Xufang Ru Jiru Zhou Mao Chen Yanling Li Mingxu Duan Yuanshu Li Wenyan Li Yujie Chen Shilun Zuo Hua Feng Source Type: research

The Progress in Molecular Transport and Therapeutic Development in Human Blood-Brain Barrier Models in Neurological Disorders
Cell Mol Neurobiol. 2024 Apr 16;44(1):34. doi: 10.1007/s10571-024-01473-6.ABSTRACTThe blood-brain barrier (BBB) is responsible for maintaining homeostasis within the central nervous system (CNS). Depending on its permeability, certain substances can penetrate the brain, while others are restricted in their passage. Therefore, the knowledge about BBB structure and function is essential for understanding physiological and pathological brain processes. Consequently, the functional models can serve as a key to help reveal this unknown. There are many in vitro models available to study molecular mechanisms that occur in the bar...
Source: Cellular and Molecular Neurobiology - April 16, 2024 Category: Cytology Authors: Joanna Korszun-Karbowniczak Zuzanna Joanna Krysiak Joanna Saluk Marcin Niemcewicz Robert Zdanowski Source Type: research

Mitochondrial Calcium Uniporter (MCU) is Involved in an Ischemic Postconditioning Effect Against Ischemic Reperfusion Brain Injury in Mice
Cell Mol Neurobiol. 2024 Apr 3;44(1):32. doi: 10.1007/s10571-024-01464-7.ABSTRACTThe phenomenon of ischemic postconditioning (PostC) is known to be neuroprotective against ischemic reperfusion (I/R) injury. One of the key processes in PostC is the opening of the mitochondrial ATP-dependent potassium (mito-KATP) channel and depolarization of the mitochondrial membrane, triggering the release of calcium ions from mitochondria through low-conductance opening of the mitochondrial permeability transition pore. Mitochondrial calcium uniporter (MCU) is known as a highly sensitive transporter for the uptake of Ca2+ present on the ...
Source: Cellular and Molecular Neurobiology - April 3, 2024 Category: Cytology Authors: Hiromitsu Sasaki Ichiro Nakagawa Takanori Furuta Shohei Yokoyama Yudai Morisaki Yasuhiko Saito Hiroyuki Nakase Source Type: research