Central European Journal of MedicineThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

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Impact of pharmaceutical dosage form on stability and dissolution of roxithromycinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The behavior of dispersible tablets containing enteric-coated pellets and oral suspension, both containing roxithromycin, was investigated using dissolution tests in different media. The dissolution test was performed under different pH conditions. For both dosage forms investigated, the test was conducted at pH 1.2, 4.5, and 6.8. Additionally, for dispersible tablets, the test involving increasing pH was performed at pH 1.2 (acid stage) and afterwards at pH 6.8 (buffer stage). The extent of dissolution was measured using high-performance liquid chromatography (HPLC). In all cases tested, roxithromy...
Source: Central European Journal of Medicine - November 11, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Plasma level of myeloperoxidase in children with juvenile idiopathic arthritis (a pilot study)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract To examine the plasma levels of MPO in oligoarthritis and polyarthritis subtypes of JIA in comparison with healthy age-matched controls. Thirty-eight JIA patients (25 girls and 13 boys) aged 9.1–11.8 years and 23 healthy controls (8 girls and 15 boys) participated in the study. Twenty-one patients had oligoarthritis (8 with extended oligoarthritis) and 17 had polyarthritis (among them three were seropositive). The plasma concentration of MPO was measured by the ELISA technique (OxisResearchTM, BIOXYTECH® MPO-EIATM, Portland, OR USA). The mean plasma concentration of MPO in the JIA group was signi...
Source: Central European Journal of Medicine - November 10, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Intracranial plasmacytoma as an initial presentation of multiple myelomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a 68-year-old woman hospitalized for acute renal failure, vertigo and headache. Magnetic Resonance Imaging (MRI) revealed two and a half and 3cm length cranial lesion, which proved to be plasmacytoma. After complete staging, we retained the diagnosis of immunoglobulin G lambda-type multiple myeloma with intracranial involvement. Cytogenetic analysis of plasma cells detected no change. Currently, she is a regular hemodialysis patient. She is planned to have both systemic therapy with 40mg dexamethasone and cranial radiotherapy. Involvement of the CNS in multiple myeloma is very rare. Diagnosis of multiple mye...
Source: Central European Journal of Medicine - November 6, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Phylogenetic analysis of house dust mitesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract House dust mites live in house dusts and affect the health of humans. Among the many species, Dermatophagoides farinae, D. pteronyssinus, and Euroglyphus maynei have been found to be commonly associated with Ig-E-mediated allergic diseases. As a result, there is increasing effort to develop methods for the diagnosis and treatment of diseases caused by these species. The purpose of the current study was to explore the evolutionary relationships among house dust mites. After adult D. farinae were separated and isolated for total RNA extract, the cDNA coding for Der f 1 and Der f 2 were cloned and sequen...
Source: Central European Journal of Medicine - November 6, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Health behavior inequalities among Lithuanian, Polish and Russian school-aged children in LithuaniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The aim of this study was to compare and get a deeper insight into issues of the health and health behavior inequalities among Lithuanian, Polish and Russian school-aged children in national and international contexts. Investigations were carried out in the framework of Health Behavior in School-aged Children (HBSC) study — a WHO collaborative cross-national survey. Five thousand seven hundred and seventy six randomly selected students aged 11, 13, and 15 years of age answered questionnaires in the classroom in 108 schools located in different regions in Lithuania in March–April of 2006. Questio...
Source: Central European Journal of Medicine - November 4, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Surmounting antimicrobial resistance in the Millennium Superbug: Staphylococcus aureusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Staphylococcus aureus is the third most dreaded pathogen posing a severe threat due to its refractory behavior against the current armamentarium of antimicrobial drugs. This is attributed to the evolution of an array of resistance mechanisms responsible for morbidity and mortality globally. Local and international travel has resulted in the movement of drug resistant S. aureus clones from hospitals into communities and further into different geographical areas where they have been responsible for epidemic outbreaks. Thus, there is a dire necessity to refrain further cross movement of these multidru...
Source: Central European Journal of Medicine - October 26, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Effects of intra-arterial heparin on cytokine levels in the ischemic tissueEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The purpose of this study was to evaluate the effects of systemic and intra-arterial application of heparin by measuring tissue levels of inflammatory cytokines. Twenty-one adult male Wistar albino rats were divided into three groups (Group A, B and C). All the rats had undergone ligation of the right femoral artery with 4-0 silk suture to induce limb ischemia. Group A was the control group. In Group B, unfractionated heparin of 1500 U/kg/day was given through the tail vein for 10 days, the same dose was given to distal part of ligated right femoral artery for 10 days in Group C. On the 3rd, 5th, an...
Source: Central European Journal of Medicine - October 26, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Is adequate and balanced nutrition during pregnancy more effective than iron and folic acid supplements?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Medical diet programs with iron sources are examined in association with food consumption. Assessment of hematological results suggests that, during pregnancy, each patient should receive a specific dose, rather than a routine dose, of iron and folic acid. Content Type Journal ArticleCategory Research ArticleDOI 10.2478/s11536-009-0099-1Authors Funda Elmacioglu, Ondokuz Mayis University Health Services 55139 Samsun TurkeyBulent Surucu, Ondokuz Mayis University Hospital Department of Obstetrics and Gynecology 55139 Samsun TurkeyTayfun Alper, Ondokuz Mayis University Hospital Department of Obstetrics and ...
Source: Central European Journal of Medicine - October 26, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Nosocomial infections and risk factors in intensive care unit of a university hospital in TurkeyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The aim of this study was to determine the types nosocomial infections (NIs) and the risk factors for NIs in the central intensive care unit (ICU) of Trakya University Hospital. The patients admitted to the ICU were observed prospectively by the unit-directed active surveillance method based on patient and the laboratory over a 9-month-period. The samples of urine, blood, sputum or tracheal aspirate were taken from the patients on the first and the third days of their hospitalization in ICU; the patients were cultured routinely. Other samples were taken and cultured if there was suspicion of an infe...
Source: Central European Journal of Medicine - October 26, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Gossypiboma mimicking a distal pancreatic mass: Report of a caseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Gossypiboma (retained surgical sponge) is a pseudotumor within the body that is composed of non-absorbable surgical material with a cotton matrix. Because the symptoms of gossypiboma usually are nonspecific and may appear years after surgery, the diagnosis of gossypiboma may be difficult because the condition may mimic a benign or malignant soft-tissue tumour in the abdomen and pelvis. A 61-year-old woman with a one-year history of left upper-quadrant pain and weight loss was referred to our center. She had undergone peptic ulcer perforation 23 year ago. Physical examination revealed dullness and pa...
Source: Central European Journal of Medicine - October 26, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Pulmonary sclerosing hemangioma with atypical radiologic findingsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of pulmonary sclerosing hemangioma with extremely unexpected imaging findings and review the literature. Content Type Journal ArticleDOI 10.2478/s11536-009-0090-xAuthors Ozgur Oztekin, Izmir Education and Research Hospital Radiology Department 35360 Izmir TurkeyRecep Savas, Ege University Faculty of Medicine Department of Radiology 35100 Izmir TurkeyDuygu Gurel, Dokuz Eylül University Faculty of Medicine Department of Pathology 35340 Izmir TurkeyNezih Ozdemir, Dokuz Eylül University Faculty of Medicine Department of Thoracic Surgery 35340 Izmir TurkeyMustafa Akcaoglu, Tepecik Education and Research...
Source: Central European Journal of Medicine - October 26, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Age-related changes in substance P-immunoreactive nerve structures of the rat recto-anal regionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined the age-related changes in the distribution of SP-immunoreactive nerve structures in the distal part of the rat large intestine. Using immunohistochemistry, the presence of SP was studied in fresh tissues from Wistar rats at different ages taken at three sampling sites, the distal rectum, anal canal and internal anal sphincter. In the 15-day old rats the myenteric plexus of the distal rectum and anal canal was well outlined by numerous SP-immunoreactive varicose nerve fibres encircling immunonegative perikarya. In the circular muscle layer, nerve fibres and small nerve bundles ran parallel to the muscle ce...
Source: Central European Journal of Medicine - October 23, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Tuberculous spondylitis in patients with end-stage renal disease undergoing chronic hemodialysis therapy — Report of two casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe two cases of tuberculous spondylitis in patients undergoing chronic hemodialysis therapy. They are IFN-γ assay diagnosed (QuantiFERON-TB Gold) and conservatively treated. Our cases suggest that IFN-γ assays equip clinicians with more accurate tools for tuberculosis control. A combination of T-SPOT.TB testing and MRI assessment may be the accurate method to diagnose tuberculous spondylitis in patients with end-stage renal disease. Content Type Journal ArticleCategory Case ReportDOI 10.2478/s11536-009-0093-7Authors Kosta Kostov, Ministry of Interior Departments of Neurology 1606 Sofia BulgariaPlamen Yo...
Source: Central European Journal of Medicine - October 21, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Bilateral caudate nucleus infarction resulting from left ventricular diastolic dysfunctionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Bilateral caudate infarct is a very rare neurological situation, usually caused by small-artery disease resulting from a cardiac embolism. The most prominent clinical features of caudate vascular lesions are behavioral and cognitive abnormalities. We report here a case of bilateral infarction of the caudate nucleus and right parietal lobe with loss of consciousness and left hemiparesia resulting from left ventricular diastolic dysfunction (LVDD). A 50-year-old woman was admitted to our clinic with symptoms of mental status change. One day ago before appearing at our clinic, the patient was hospitali...
Source: Central European Journal of Medicine - October 21, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Severe hyperphosphatemia and symptomatic hypocalcemia after bowel cleansing with oral sodium phosphate solution in a patient with postoperative hypoparathyroidismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of postoperative hypoparathyroidism who developed severe hyperphosphatemia and associated hypocalcemia after bowel preparation with oral NaP. A 39-year old woman was admitted to the hospital because of multiple bone fractures. The diagnosis of primary hyperparathyroidism was confirmed. Further assays suggested Cushing’s disease and MRI disclosed a pituitary microadenoma. Considering the diagnostic suspect of multiple endocrine neoplasia type 1, computed tomography of abdomen was performed, showing a mass in the right adrenal. The patient underwent transsphenoidal surgery and then total parathyroidec...
Source: Central European Journal of Medicine - October 21, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Left ventricular myxoma: Confusing intracardiac mass in a patient with leukemia in remissionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report an unusual case of a 21-year-old woman with a leukemia in remission, in whom routine transthorasic echocardiographic examination demonstrated an incidental left ventricular mass. The patient underwent successful resection of the left ventricular mass under cardiopulmonary bypass through the left atrial approach. Histopathologic examination was diagnostic for myxoma. In this case, the presentation of the mass was atypical for two reasons: the tumour was a cardiac myxoma in the left ventricular localisation and in a patient with leukemia in remission. Content Type Journal ArticleCategory Case ReportDOI 10.24...
Source: Central European Journal of Medicine - October 21, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Differences in clinical predictors of influenza in adults and children with influenza-like illnessEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Influenza contributes significantly to morbidity and mortality in the winter season. The aim of the study was to identify clinical signs and symptoms most predictive of influenza infection in children and adults with influenza-like illness. A prospective systematic sampling analysis of clinical data collected through sentinel surveillance system for influenza in 32 primary care centers and one tertiary care hospital in Slovenia during two consecutive influenza seasons (2004/2005 and 2005/2006) was carried out. Children and adults who had influenza-like illness, defined as febrille illness with sudde...
Source: Central European Journal of Medicine - October 21, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

The value of histological changes and immunohistochemical markers Ki67 and p53 in the assessment of ulcerative colitis related dysplasiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The risk of carcinoma increases in patients with a 10-year or longer duration of ulcerative colitis (UC). To search for a more objective parameter to assess epithelial dysplasia. The study comprised 25 cases of longstanding UC: 7 cases with regenerative atypia, 7 with low grade dysplasia, 7 with high grade dysplasia, and 4 cases indefinite for dysplasia. The colonic biopsies obtained during endoscopy were stained with H&E to identify the aforementioned categories. Seventy-five sections from biopsy specimens were stained immunohistochemically to detect differences in the frequency and pattern of nucl...
Source: Central European Journal of Medicine - October 21, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Preoperative anemia associated in-hospital mortality and morbidity in isolated coronary artery bypass graft surgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Anemia is an indisputable finding in patients scheduled for coronary artery bypass graft (CABG) that can occur any time preoperatively. In presence of severe coronary artery disease, anemia can dramatically affect surgical outcomes. Therefore, we conducted this study to determine the effect of low preoperative hemoglobin (Hgb) on postoperative outcome in patients who underwent coronary artery bypass graft (CABG). In all, 4432 patients who had undergone isolated CABG at Tehran Heart Center over the 2-year period from March 2006 to February 2008 were studied. All medical records of the aforementioned ...
Source: Central European Journal of Medicine - September 16, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Effects of lead on thyroid functions in lead-exposed workersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Lead exposure is a common public health problem. Exposure to the metal can cause hematological, gastrointestinal, rheumatological, endocrine, neurological and renal problems in humans. However, effects on the thyroid gland are controversial. We retrospectively investigated thyroid function parameters in 65 adult males who had been occupationally exposed to lead. We then compared the findings with those of 60 male patients who had no history of lead exposure or thyroid abnormalities, who served as the control group. The mean ages of the lead-exposed workers and the controls were 34.3 ± 7.9 and 32.9 ...
Source: Central European Journal of Medicine - September 16, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Ten-year prevalence of fungal peritonitis in the city of Nis, South SerbiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Fungal peritonitis is a rare but serious complication in patients with chronic renal failure on continuous ambulatory peritoneal dialysis (CAPD). The purpose of this study was to report the prevalence of fungal peritonitis in patients on CAPD in the Clinical Center-Nis (South Serbia) in the period from 1997 until the end of 2007. Fungal species were isolated in 66 cases (4.5%) of 1471 peritoneal fluid (PF) samples that we examined. During the study period, 22 (1.5%) cases of fungal peritonitis were registered. In 19 cases, Candida isolates were identified, Candida albicans (C. albicans) being the mo...
Source: Central European Journal of Medicine - August 14, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Knowledge, attitudes and practices towards blood-borne pathogens in healthcare workers in Banja Luka, Bosnia and HerzegovinaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was undertaken to investigate knowledge, attitudes and practices among HCWs towards blood borne pathogens. We carried out a cross sectional KAP (Knowledge, Attitudes and Practice) study, using self-administered questionnaire. The study population consisted of 127(23.6%) physicians, and 410 (76.4%) nurses and laboratory technicians. Factor analysis and conditional multiple logistic regression were used in statistical analysis. We found that the knowledge of the epidemiological characteristics of blood-borne infection, the risk of acquisition and available preventative measures among HCWs is insufficient. Doct...
Source: Central European Journal of Medicine - July 30, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Familial multiple myeloma. Two more familiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The authors report on two multiple myeloma sibling pairs. In the absence of a known disease-specific marker one can only speculate on an explanation: is it because of inherited errors or is it related to the same environmental exposure, or both? In this study HLA typing and metabolizing enzyme polymorphism studies have been carried out with the aim of finding inherited similarities in the siblings or characteristics that might differ from the average population. Sibling pair 1 shared an HLA haplotype. Sibling pair 2 shared only HLA-B51, DR4, DRw53, DQ3. Sibling 1/1 was GSTT1 / GSTM1 null and GSTP1 I...
Source: Central European Journal of Medicine - July 30, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Tuberculous bursitis of the wrist after anti-TNFalpha treatment: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this report, we describe a case of tuberculous bursitis-osteomyelitis of the wrist, in an elderly patient with rheumatoid arthritis and anti-TNFalpha (anti-Tumor Necrosis Factor alpha) treatment. Content Type Journal ArticleCategory Case ReportDOI 10.2478/s11536-009-0078-6Authors Avgoustidis Nestor, National and Kapodistrian University of Athens Pathophysiology Department, Laikon General Hospital and Medical School 11527 Athens GreeceSipsas Nikolaos, National and Kapodistrian University of Athens Pathophysiology Department, Laikon General Hospital and Medical School 11527 Athens GreeceEvangelou Konstantinos, Natio...
Source: Central European Journal of Medicine - July 25, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Autoimmune thyroid disease in patients with anti-GAD positive type 1 diabetes mellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The aim of the study was to determine the frequency and titers of anti-thyroid peroxidase (Anti-TPO), anti-thyroglobulin (Anti-TG), and anti-glutamic acid decarboxylase (Anti-GAD) antibodies in Turkish patients with type 1 diabetes mellitus (DM), and to compare the frequency of anti-TPO and anti-TG titers in the presence or absence of anti-GAD. A total of 104 patients including 56 males and 48 females with type 1 DM and their age-, gender-, and body mass index-matched control group, including 31 males and 27 females, 58 cases in total with an age range of 15-50 years, were recruited into this study....
Source: Central European Journal of Medicine - July 25, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

The effects of vitamin E and selenium on blood flow to experimental skin burns in rats using the 133Xe clearance techniqueEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The aim of the present experimental study was to determine and to compare the effects of vitamin E and of selenium on the blood flow to a wound region in rats, using the xenon-133 (133Xe) clearance technique. Burn wounds were made on the right thighs of rats followed by oral administration of vitamin E or selenium for a period of 10 days. The effect of vitamin E and of selenium individually on blood flow in the wound region was assessed before and after oral administration using the 133Xe clearance technique. Both vitamin E and selenium significantly increased the blood flow in the wound region (P<...
Source: Central European Journal of Medicine - July 25, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Manifestation peculiarities of idiopathic chronic eosinophilic pneumoniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, in cases of not typical pneumonia course, i.e. non-resolving or recurrent pulmonary infiltrates; relative mild clinical symptoms and moderate increased CRP level with multiple pulmonary infiltrates; blood eosinophilia and/or signs of airway obstruction eosinophilic pneumonia should be suspected and bronchoalveolar lavage and/or bronchoscopic lung biopsy performed. Content Type Journal ArticleCategory Research ArticleDOI 10.2478/s11536-009-0082-xAuthors Edvardas Danila, Allergology and Radiology of Vilnius University Clinic of Chest Diseases LT 08661 Vilnius LithuaniaJolita Norkūnienė, Gediminas Tec...
Source: Central European Journal of Medicine - July 25, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Cognitive functions and clinical features among diabetic patients in Polish populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Diabetes is a chronic metabolic disease which can lead to numerous complications. One of these disturbances is cognitive function impairment. A group of 62 patients with type 1 and type 2 diabetes. There is a correlation between certain clinical features among diabetic patients and cognitive functions. Negative influence on cognitive functions have a higher level of total cholesterol, a higher level of LDL cholesterol, a lower level of HDL cholesterol concentration in the blood, a higher level of glucose after meals, a higher level of basic insulin dose and insulin dose taken just before the examina...
Source: Central European Journal of Medicine - July 25, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Risk factors for vancomycin-resistant enteroccocci colonization in infants in neonatal intensive care unitEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract We aimed to evaluate the risk factors for VRE colonization in neonatal intensive care units. In December 2007, we identified a neonate with VRE infection (urinary tract infection and we performed blood and stool cultures for VRE until the last colonized patient was discharged from our clinic. All the neonates hospitalized in NICU during December 2007 to January 2008. Active surveillance cultures for VRE fecal carriage was carried out in neonatal intensive care unit. Resistance to vancomycin was detected by the E-test method. Epidemiological data was recorded for all patients included in the study an...
Source: Central European Journal of Medicine - July 13, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Accuracy of quantitative ultrasound parameters in the diagnosis of osteoporosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Quantitative ultrasound (QUS) is of increasing interest for evaluation of osteoporosis because, compared with dual-energy X-ray absorptiometry (DXA), it is portable, less expensive, and radiation-free. The aim of our study was to determine the sensitivity, specificity, and cut-off values of quantitative ultrasound parameters in identifying patients with osteoporosis compared to the World Health Organization (WHO) standard definition. We performed a cross-sectional investigational study of 73 subjects, and determined total hip and lumbar spine T-scores by dual-energy X-ray absorptiometry (DXA) (Prodi...
Source: Central European Journal of Medicine - July 13, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Effects of an EE/CA compared with EE/CA-metformin on serum ADMA levels in women with polycystic ovary syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract To determine the effects of EE/CA (Ethinylestradiol/ Cyproterone Acetate) and EE/CA-metformin treatments on the asymmetric dimethylarginine (ADMA) levels in women with PCOS (Polycystic Ovary Syndrome). Among 43 patients diagnosed with PCOS, one study arm (n=22) was administered (35 µg EE, 2mg CA) and the other (n=21) was administered (35 µg EE, 2mg CA plus 1700mg metformin). Serum ADMA, lipid profile, androgens, insulin, and HOMA-IR (Homeostatic Model Assessment of Insulin Resistance ) values were assessed prior to treatment and after 3 months of therapy. A significant reduction in ADMA levels rel...
Source: Central European Journal of Medicine - July 13, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Changes in antioxidative parameters in the kidney of rats subchronically intoxicated with chlorfenvinphos — an organophosphate insecticideEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Chlorfenvinphos is an organophosphate insecticide, posing a risk to those who are professionally involved in its production and use in agriculture, as well as to the general population. Organophosphates (OPs) are the class of insecticides, whose primary target is acetylcholinesterase (AChE) that hydrolyzes acetylcholine, a major neurotransmitter at the central and peripheral neuronal synapses. Moreover, many authors postulate that these compounds, both in acute and chronic intoxication, change the activities of antioxidative enzymes, thus leading to the enhancement of lipid peroxidation in many tiss...
Source: Central European Journal of Medicine - July 13, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Taxane-based adjuvant chemotherapy in node positive, early stage Turkish breast cancer patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, this trial once more demonstrated that taxane-based adjuvant chemotherapy was effective and safe in lymph node-positive, early-stage Turkish breast cancer patients. Content Type Journal ArticleCategory Research ArticleDOI 10.2478/s11536-009-0075-9Authors Ahmet Alacacioglu, Izmir Research and Training Hospital Medical Oncology 35360 Bozyaka, Izmir TurkeyBaha Zengel, Izmir Research and Training Hospital Clinic of 1.General Surgery 35360 Bozyaka, Izmir TurkeyAli Galip Denecli, Izmir Research and Training Hospital Clinic of 1.General Surgery 35360 Bozyaka, Izmir Turkey Journal Central European Journ...
Source: Central European Journal of Medicine - July 13, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Serum levels of resistin and hsCRP in women with PCOSEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Resistin has been associated with obesity and type 2 diabetes. The elevated serum resistin level in human diabetes is often associated with a pro-inflammatory milieu. In vitro data suggest that C-reactive protein (CRP) significantly increases resistin expression in cultured human PBMC, yet the relationship in vivo is largely unknown. The purpose of this study was to determine the concentrations of CRP and resistin in women with polycystic ovary syndrome (PCOS) and to clarify whether or not there are correlations between CRP and resistin levels that have not previously been studied in PCOS in the con...
Source: Central European Journal of Medicine - July 13, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Polymorphisms in genes involved in folate metabolism as maternal risk factors for Down syndrome — meta-analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, our meta-analysis showed the significance of genetic alterations in the folate metabolism genes in maternal susceptibility to DS offspring. Our results suggest that the importance of folate supplementation to women in reproductive age in prevention of non-disjunction be revised. Further genetic studies on a combined effect of multiple folate metabolism genes is recommended. Additionally, more thorough studies on the haplotype analyses of genes is recommended as well, especially in populations that have not yet been investigated thus far. Content Type Journal ArticleCategory Research ArticleDOI 10.2478...
Source: Central European Journal of Medicine - July 13, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Platelet indices in patients with colorectal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The interaction between cancer cells and platelets has been known for a long time. Although platelet indices have been also investigated in several clinical settings, it has not been exactly demonstrated in cancer patients. We investigated platelet indices in colorectal cancer patients and compared with healthy subjects. Two hundred and twenty-one colorectal cancer patients and 110 healthy subjects were enrolled into the retrospective study. Data were obtained from computerized medical records of our hospital. Medical record review was performed for all patients regarding thrombocyte indices. Platel...
Source: Central European Journal of Medicine - July 13, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Peripheral blood CD4+CRTH2+ cells in advanced stage non small cell lung cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract To investigate CD4+CRTH2+ cells in peripheral blood in advanced stage non small cell lung cancer (NSCLC) patients. Forty-six patients with advanced stage NSCLC, who are chemotherapy or radiotherapy naïve, and 17 healthy volunteers, were enrolled in this study. The study was performed using flow cytometry and a complete blood cell counter analyser. CD4+ T cell percentage, CD4/CD8 ratio, CRTH2+CD4+ cell percentages, counts, and mean fluorescein intensity (MFI) and hematological parameters were evaluated in both groups. A survival analysis was performed to compare the patients with high CD4+CRTH2+ cel...
Source: Central European Journal of Medicine - July 1, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Quality of life in Lithuanian population: the impact of country residence and socio-economic statusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Quality of life (QoL) and individual perception of health has become a subject of great interest in Lithuania. The relationships between country residence, socio-economic status (SES), and QoL have not been well characterized among the Lithuanian urban and rural populations. The aim of the study was to assess the influence of country residence and SES on QoL in Lithuanian urban and rural population adjusting for the influence of other known determinants of QoL. The study population was randomly selected from 1193 urban and 264 rural men and women aged 45–72 years and have been filled in the self-a...
Source: Central European Journal of Medicine - July 1, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Acute pancreatitis after nifedipine and acetaminophen poisoning — case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a case of a young woman with acute pancreatitis secondary to an overdose of nifedipine and acetaminophen in a suicide attempt. We excluded other causes of acute pancreatitis by clinical history, serum toxicology, serology, and abdominal imaging. The most likely underlying pathophysiological mechanism was ischemic injury of the pancreas secondary to severe collapse induced by nifedipine and possible acetaminophen-induced direct pancreatotoxicity. The pancreatitis resolved with treatment that included continuous veno-venous haemofiltration in an intensive care unit. Emergency and intensive care units should b...
Source: Central European Journal of Medicine - July 1, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

An unusual form of Gaucher’s disease: pulmonary and cardiovascular involvement and cholelitiasisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report presents these rare findings made by conventional radiography, computerized tomography (CT), and High-resolution CT (HRCT) of a 16-year-old female patient with fatal Gaucher’s disease. Content Type Journal ArticleCategory Research ArticleDOI 10.2478/s11536-009-0062-1Authors Meltem Ceyhan, Departments of Radiology Ondokuz Mayis University 55139 Samsun TurkeyFatma Cakmak Celik, Departments of Pediatrics Ondokuz Mayis University 55139 Samsun TurkeyMuzaffer Elmali, Departments of Radiology Ondokuz Mayis University 55139 Samsun TurkeyNevzat Gurmen, Departments of Radiology Ondokuz Mayis University 55139 Sams...
Source: Central European Journal of Medicine - July 1, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Coronary artery disease associated with radiation therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Recent advancements in curative-intent therapies have led to dramatic improvements in breast cancer-specific mortality but at the direct expense of increased risk of cardiovascular-related mortality. The use of radiation therapy has led to significant improvements in survival for patients treated for breast cancer. However, as patients live longer, the potentially serious adverse effects of radiation on the heart have raised concerns. Coronary artery disease following irradiation is encountered rarely but is one of the most devastating treatable complications.In this article we review the cardiac co...
Source: Central European Journal of Medicine - July 1, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

In hospital costs of acute heart failure patients in the Czech RepublicEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The retrospective cost analysis estimates direct in-patient costs and length of stay (LOS) in hospital for acute heart failure (AHF). Patients were hospitalized with acute decompensation (ADHF) or de novo AHF in the Faculty Hospital Brno in 2005 and 2006. Burden incurred is divided to standard cardiology unit (SCU) and intensive care unit (ICU). In-patient care costs include flat rate of admission, stay and medicinal procedures. The pharmaceuticals are included in daily in-patient rate; angiography, revascularizations and antiarrhythmic interventions are calculated separately. In total, 734 patients...
Source: Central European Journal of Medicine - July 1, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Risk assessment in coronary patients undergoing abdominal nonvascular surgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The aim of our study was to establish that the incidence of perioperative cardiac complications were in direct correlation with level of operative risk in coronary patients undergoing open abdominal nonvascular surgery with general anesthesia. Our prospective observational clinical study was composed of a group of 111 consecutive patients with angiographically-verified coronary artery disease, who were operated on at the University Clinical Center of Serbia. The patients were classified into four stratification subgroups by “Goldman’s Cardiac Risk Index” (CRI) in relation to the incidence of p...
Source: Central European Journal of Medicine - July 1, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Association of osteoprotegerin and rankl levels with insulin resistance in pubertal obese childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Osteoprotegerin (OPG)/“receptor activator of nuclear factor kappa B-ligand” (RANKL) system has an important role in the remodeling of bone through regulation of osteoclastogenesis. We aimed to detect OPG and RANKL levels, particularly in obese children in the pubertal period and to investigate whether these parameters correlate with insulin resistance in childhood. Our study included 66 obese children ranging in age from 9.1 to 16 years, and 22 non-obese children ranging in age from 10.5 to 16 years. Blood glucose, insulin, total cholesterol, HDL cholesterol, and LDL cholesterol levels were meas...
Source: Central European Journal of Medicine - July 1, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Secondary cold agglutinin disease associated with Hashimoto diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Our case involves a 53 year old woman. Three years ago, she was investigated because of normal hemoglobin levels despite very a low erythrocyte count, which was revealed during the preoperative evaluation for ovarian cyst operation. The Direct Coombs test was found to be positive against complement and negative against IgG. Cold agglutinin titer was 1/448 (+). Due to the polyclonal IgM increase, secondary cold agglutinin disease (CAD) was considered but no factor could be found that would lead to cold agglutinin disease. During the post-operative follow-up, cold agglutinin titers increased with fluc...
Source: Central European Journal of Medicine - July 1, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Invasive giant basal cell carcinoma of the head: case report, reconstruction choice and literature reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract It is unusual to find a giant invasive basal cell carcinoma in the occipital region of the head. We are presenting a case of basal cell carcinoma invading and eroding occipital bone, managed with an unusual scalp reconstruction method. A 69-year-old female presented with a 16x19 cm diameter tumour in the occipital region. Preoperative biopsy revealed a basal cell carcinoma. A complete surgical excision of the tumour was performed in one-step surgery and tissue defect was reconstructed by a pedicle latissimus dorsi musculocutaneous flap. Our case shows that this distant pedicle flap is safe and relia...
Source: Central European Journal of Medicine - July 1, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

The value of transabdominal ultrasound for assessment of the severity of liver steatosis as compared to liver biopsyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study showed that the transabdominal ultrasound evaluation of the fatty liver is a quite good predictor, perhaps sufficient for most purposes, for the estimation of the severity of liver steatosis in the moderate to severe range. Content Type Journal ArticleCategory Research ArticleDOI 10.2478/s11536-009-0067-9Authors Ioan Sporea, University of Medicine and Pharmacy Timişoara Department of Gastroenterology and Hepatology 300736 Timişoara RomâniaRoxana Şirli, University of Medicine and Pharmacy Timişoara Department of Gastroenterology and Hepatology 300736 Timişoara RomâniaElena Başa, University of Medic...
Source: Central European Journal of Medicine - July 1, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Does diabetes affect the intensity of staining of interstitial cells and neuronal tissue in the bladder, prostate and urethra of rabbits?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract We compared the intensity of staining of interstitial cells (ICs) and neural tissue in the lower urinary tract of rabbits with diabetes with the intensity in normal subjects. Diabetes was induced by injecting alloxane (65mg/kg) in adult male rabbits. After 3 days, rabbits with a blood glucose level >300 mg/dL were considered to have diabetes. After 8 weeks, the rabbits were killed, and tissue specimens from the bladder, prostate and urethra were obtained. ICs were stained with anti-human CD117 (c-kit) rabbit polyclonal antibody, and neural tissue was stained with synaptophysin. The streptavidin-b...
Source: Central European Journal of Medicine - July 1, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Chemometrics as an option to assess clinical data from diabetes mellitus type 2 patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The present study deals with the application of two major multivariate statistical approaches - Cluster Analysis (CA) and Principal Components Analysis (PCA) as an option for assessment of clinical data from diabetes mellitus type 2 patients. One hundred clinical cases of patients are considered as object of the statistical classification and modeling, each one of them characterized by 34 various clinical parameters. The goal of the study was to find patterns of similarity, both between the patients and the clinical tests. Each group of similarity is interpreted revealing at least five clusters of c...
Source: Central European Journal of Medicine - June 30, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals

Gross pericardial effusion with tamponade in 2nd trimester of pregnancyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a case of successfully treated gross pericardial effusion and tamponade in a 22-week pregnant woman with hypothyroidism. The patient was treated by pericardial drainage with further treatment of hypothyroidism with levothyroxine. During the follow-up pregnancy was uncomplicated without recurrence of pericardial effusion and successful delivery of full-term baby. We conclude that careful monitoring of thyroid functional tests and proper management should be performed in pregnant women with hypothyroidism to prevent cardiac complications of the disease, like pericardial effusion and tamponade. Content Type...
Source: Central European Journal of Medicine - June 10, 2009 Category: Journals (General) Tags: Central European Journal of Medicine Source Type: journals