CephalexinThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you your search results in order of date.

Pages: 1 2 3

102 records returned

Effects of Acanthopanax senticosus HARMS extract on drug transport in human intestinal cell line Caco-2Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we investigated the effect of AS extract on intestinal drug transporter (P-glycoprotein, or P-gp) and peptide transporter activities in Caco-2 cells. Caco-2 cells were cultured on a culture dish and a permeable membrane for 1–3 weeks. The apical-to-basolateral (A-to-B) transport of digoxin, a P-gp substrate, was significantly increased by the addition of AS extract in a concentration-dependent manner. In contrast, the A-to-B transport of cephalexin, a peptide transporter substrate, was significantly decreased by the addition of AS extract in the same manner. The effects of AS extract addition on ...
Source: Journal of Natural Medicines - November 5, 2009 Category: Drugs & Pharmacology Tags: Journal of Natural Medicines Source Type: journals

The effect of wellsolve, a novel solubilizing agent, on the intestinal barrier function and intestinal absorption of griseofulvin in rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The effect of Wellsolve, a new solubilizing agent, on the function of intestinal membrane barrier and transporters including P-glycoprotein (P-gp) and peptide transporter (PEPT1) was examined by an in vitro diffusion chamber and an in situ closed loop method. The model drugs used in this study were 5(6)-carboxyfluorescein (CF), rhodamine123 (a P-glycoprotein substrate), cephalexin (a typical substrate for PEPT1) and griseofulvin (a BCS Class II drug). Intestinal absorption of CF was not affected by the addition of 1-10% (v/v) Wellsolve, while 20% (v/v) Wellsolve significantly enhanced its intestinal absorption by the i...
Source: Biological and Pharmaceutical Bulletin - November 1, 2009 Category: Drugs & Pharmacology Authors: Hamid KA, Lin Y, Gao Y, Katsumi H, Sakane T, Yamamoto A Tags: Biol Pharm Bull Source Type: journals

Resistance pattern of breakthrough urinary tract infections in children on antibiotic prophylaxisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the resistance pattern of organisms causing breakthrough UTIs varies with the choice of prophylaxis which should be taken into consideration in chosing empiric therapy for such infections. (Source: Journal of Infection and Public Health)
Source: Journal of Infection and Public Health - October 15, 2009 Category: Global & Universal Authors: Ali Reza Nateghian, Joan L. Robinson, Shahab Mohandessi, Nakysa Hooman Tags: Original Articles Source Type: journals

Mycobacterium marinum Granuloma in a FishermanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
While fishing in the Chesapeake Bay, an 81-year-old man slipped and fell into the water. Afterward, he noticed a superficial abrasion over his right knee. During the next 10 days, red bumps, pustules, and slight tenderness developed. He was treated empirically with mupirocin ointment, amoxicillin/clavulanate and subsequently with cephalexin. However, new papular lesions continued to develop adjacent to the area of involvement, which showed no signs of healing. (Source: Consultant Live)
Source: Consultant Live - October 5, 2009 Category: Primary Care Source Type: info

How to Stay Sharp as a TackEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(NaturalNews) A few days ago a song got stuck in my head- the slow, haunting violin melody that set the mood in the movie Platoon. But I couldn't recall who wrote it, and it bugged me. Later, when I wasn't thinking about it, I suddenly remembered it was Samuel Barber's Adagio for Strings.We all have episodes like this. We forget names and misplace things. We lose our train of thought, and we walk into rooms with no recollection of why we went there in the first place. This is normal human behavior. Now, forgetting a close family member's name, constantly repeating yourself, or getting lost in familiar places is another iss...
Source: NaturalNews.com - October 2, 2009 Category: Consumer Health Advice Source Type: news

CEPHALEXINsuspension CEPHALEXIN (Cephalexin) Suspension [West-Ward Pharmaceutical Corp]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Sep 30, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - September 30, 2009 Category: Drugs & Pharmacology Source Type: organizations

Antibiotic Resistance in Bacteria: Novel Metalloenzyme InhibitorsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
[beta]-Lactam antibiotics are among the most important drugs used to fight bacterial infection. Overuse and misuse of [beta]-lactam antibiotics has caused the evolution of resistance mechanisms, allowing pathogenic bacteria to survive antibiotic treatment. The major source of resistance to [beta]-lactam antibiotics occurs through production of enzymes called [beta]-lactamases capable of catalyzing hydrolysis of the [beta]-lactam rings in these drug compounds. The metallo-[beta]-lactamases have become a major threat due to their broad substrate specificities; there are no clinically useful inhibitors for these metalloenzyme...
Source: Chemical Biology and Drug Design - September 8, 2009 Category: Biology Authors: Sung-Kun Kim, Cynthe L. Sims, Susan E. Wozniak, Stephanie H. Drude, Dustin Whitson, Robert W. Shaw Tags: Research Articles Source Type: journals

Marked hydronephrosis and hydroureter after distigmine therapy in an adult male patient with paraplegia due to spinal cord injury: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Distigmine therapy resulted in marked bilateral hydronephrosis and hydroureter. Persistence of hydronephrosis after omitting distigmine, and presence of residual urine in bladder over many years probably predisposed to formation of polypoid cystitis and follicular cystitis, and contributed to prolonged haematuria, which occurred after an episode of urine infection. This case illustrates the dangers of prescribing distigmine to promote spontaneous voiding in spinal cord injury patients. Instead of using distigmine, spinal cord injury patients should be advised to consider intermittent catheterisation together wi...
Source: Cases Journal - August 5, 2009 Category: Journals (General) Source Type: journals

Direct Evidence for Efficient Transport and Minimal Metabolism of L-Cephalexin by Oligopeptide Transporter 1 in Budded Baculovirus Fraction.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The oligopeptide transporter PEPT1 (SLC15A1) is responsible for absorption of peptidic nutrients in the small intestine. Although the L-diastereomer of the beta-lactam antibiotic cephalexin (L-cephalexin) is likely to be transported by PEPT1, there has been no direct demonstration of PEPT1-mediated L-cephalexin transport. Indeed, after the incubation with L-cephalexin, the intact form of L-cephalexin has not been identified inside vesicles/proteoliposomes prepared from brush border membrane of intestinal epithelial cells or cultured cell lines exogenously transfected with PEPT1 gene. Thus, it appears that L-cephalexin ...
Source: Biological and Pharmaceutical Bulletin - August 5, 2009 Category: Drugs & Pharmacology Authors: Mitsuoka K, Tamai I, Morohashi Y, Kubo Y, Saitoh R, Tsuji A, Kato Y Tags: Biol Pharm Bull Source Type: journals

I PREVENT Bacterial Resistance. An Update on the Use of Antibiotics in Dermatologic SurgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Prophylaxis may be given to prevent a surgical wound infection, infective endocarditis (IE), or infection of a prosthetic joint, but its use before cutaneous surgery is controversial. Our aim was to review the current literature and provide a mnemonic to assist providers in appropriately prescribing prophylactic antibiotics. We reviewed the current literature, including the new guidelines provided by the American Heart Association (AHA). The new AHA guidelines recommend prophylaxis for patients with high risk of an adverse outcome from IE instead of high risk of developing IE. The American Academy of Orthopedic Surgeons an...
Source: Dermatologic Surgery - July 19, 2009 Category: Dermatology Authors: CHRISTINE MOORHEAD, ABEL TORRES Source Type: journals

Disseminated histoplasmosis with colonic ulcers in a patient receiving infliximabEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 76-year-old woman was admitted after sustaining a fall. After further questioning, she noted some painful erythema of the left upper extremity that had been present for several months, despite a recent course of cephalexin. The patient had a history of rheumatoid arthritis that was being treated with methotrexate; however, she had recently, approximately 3 months earlier, started therapy with infliximab. On admission, the patient was febrile and tachycardic. Physical examination revealed painful erythema over the left hand, wrist, and forearm. A routine complete blood count revealed 10,900 leukocytes per cubic millimeter...
Source: Gastrointestinal Endoscopy - July 1, 2009 Category: Gastroenterology Authors: Neil Gupta, Christopher M. Fox, Scott W. Grisolano Tags: Brief Reports Source Type: journals

Research of urinary tract infections in family medicine physicians' offices--empiric antimicrobial therapy of urinary tract infections--Croatian experience.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the period between October 1st and November 30th, 2006, we investigated a total of 3188 episodes of UTI (802 among males; 2386 among females) recorded in 108 family medicine offices in 20 cities in Croatia. The most common UTIs in women were acute uncomplicated cystitis (62%), complicated UTIs - cystitis and pyelonephritis (14%), urethritis (9%), acute uncomplicated pyelonephritis (6%), recurrent cystitis (5%), asymptomatic bacteriuria (3%) and recurrent pyelonephritis. The most common UTIs in men were complicated UTIs - cystitis and pyelonephritis (48%), urethritis (25%), prostatitis (24%) and asymptomatic bacteriu...
Source: Collegium Antropologicum - May 31, 2009 Category: Epidemiology Authors: Skerk V, Skerk V, Jaksić J, Lakos AK, Matrapazovski M, Maleković G, Andrasević AT, Radoaević V, Markotić A, Begovac J Tags: Coll Antropol Source Type: journals

A new semi-selective medium for the isolation of Xanthomonas axonopodis pv. dieffenbachiae, the etiological agent of anthurium bacterial blightEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Growth of the anthurium blight pathogen was better on NCTM4 and ET media than on CS. NCTM4 provided a better repeatability. It also displayed a lower rate of false positive and false negative results when the pathogen was isolated from plant extracts.Significance and Impact of the Study: This study will lead to improved isolation protocols of the anthurium blight in official procedures. NCTM4 medium could also favourably be used in studies, which aim to further understanding of the biology and epidemiology of this pathogen. (Source: Letters in Applied Microbiology)
Source: Letters in Applied Microbiology - May 16, 2009 Category: Microbiology Authors: P. Laurent, A. Chabirand, E. Jouen, I. Robène-Soustrade, L. Gagnevin, B. Hostachy, O. Pruvost Source Type: journals

Cephalexin Residue Detection in Milk and Beef by ELISA and Colloidal Gold Based One-Step Strip AssayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Journal of Agricultural and Food Chemistry, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Agricultural and Food Chemistry)
Source: Journal of Agricultural and Food Chemistry - May 14, 2009 Category: Food Science Tags: article Source Type: journals

Measurement and Modeling Process Partitioning of Cephalexin Antibiotic in Aqueous Two-Phase Systems Containing Poly(ethylene glycol) 4000, 10000 and K2HPO4, Na3CitrateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Journal of Chemical & Engineering Data, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Chemical and Engineering Data)
Source: Journal of Chemical and Engineering Data - May 9, 2009 Category: Chemistry Tags: article Source Type: journals

Antibiotic Selection for Purulent Skin and Soft-Tissue Infections in Ambulatory Care: A Decision-Analytic ApproachEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Objective: Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has caused a nationwide epidemic of skin and soft-tissue infections in ambulatory pediatrics. Antibiotic treatment recommendations suggest incorporating local epidemiology for the prevalence of CA-MRSA. We sought to identify the antibiotic strategy with the highest probability of activity and to identify threshold values for epidemiologic variables including bacterial prevalence and antibiotic resistance.Methods: We used decision analysis to evaluate 3 empiric antibiotic strategies: clindamycin, trimethoprim/sulfamethoxazole (T/S), and ce...
Source: Academic Pediatrics - May 1, 2009 Category: Pediatrics Authors: Adam L. Hersh, Peggy S. Weintrub, Michael D. Cabana Tags: Primary Care Source Type: journals

A new biocatalyst: Penicillin G acylase immobilized in sol-gel micro-particles with magnetic properties.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The present work focuses on the development and basic characterization of a new magnetic biocatalyst, namely penicillin G acylase (PGA), immobilized in sol-gel matrices with magnetic properties, ultimately aimed for application in cephalexin (CEX) synthesis. A mechanically stable carrier, based on porous xerogels silica matrixes starting from tetramethoxysilane (TMOS), was prepared leading to micro-carriers with medium sized particles of 30 microm, as determined by scanning electron microscopy. An immobilization yield of 95-100% and a recovered activity of 50-65% at 37 degrees C, as determined by penicillin G (PG) hydr...
Source: Biotechnology Journal - May 1, 2009 Category: Biotechnology Authors: Bernardino SM, Fernandes P, Fonseca LP Tags: Biotechnol J Source Type: journals

Treatment of Staphylococcus aureus Colonization in Atopic Dermatitis Decreases Disease SeverityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS. Chronic use of dilute bleach baths with intermittent intranasal application of mupirocin ointment decreased the clinical severity of atopic dermatitis in patients with clinical signs of secondary bacterial infections. Patients with atopic dermatitis do not seem to have increased susceptibility to infection or colonization with resistant strains of S aureus. (Source: PEDIATRICS)
Source: PEDIATRICS - April 27, 2009 Category: Pediatrics Authors: Huang, J. T., Abrams, M., Tlougan, B., Rademaker, A., Paller, A. S. Tags: Infectious Disease & Immunity ARTICLES Source Type: journals

Mechanism and implication of cephalosporin penetration into oropharyngeal mucosaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract The aim of this study was to explore the mechanism(s) by which oral cephalosporins penetrate into human oropharyngeal mucosa, and thus, the availability of sufficient concentrations at the site of infection. Two oral cephalosporin prototypes, cephalexin (first generation) and cefixime (third generation), were administered to five healthy subjects at two different visits with a 1-week washout period. Plasma and saliva samples were collected and drug concentrations were measured using an appropriate HPLC method. The maximum plasma concentrations (Cmax) of cefixime and cephalexin were 2.97 ± 0.24 μg ...
Source: Journal of Infection and Chemotherapy - April 25, 2009 Category: Infectious Diseases Tags: Journal of Infection and Chemotherapy Source Type: journals

Usefulness of antibiogram surveillance for methicillin-resistant Staphylococcus aureus in outpatient pediatric populationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: We assessed the impact of distributing an outpatient age-specific methicillin-resistant Staphylococcus aureus (MRSA) antibiogram on physician knowledge of MRSA prevalence and choice of empiric therapy. Questionnaires were given to 125 physicians at outpatient pediatric clinics in Monroe County, NY, before and after antibiogram distribution (response rates, 42% and 24%, respectively). The median physician-estimated MRSA prevalence (among S. aureus skin infections) was 15% before they received the antibiogram and 20% after. According to the antibiogram, the true 2005 prevalence was 25% among skin infections. When a...
Source: Diagnostic Microbiology and Infectious Disease - April 20, 2009 Category: Microbiology Authors: Jessina C. McGregor, Ghinwa Dumyati, Aida E. Casiano-Colón, Pei-Jean Chang, R. Monina Klevens Tags: Antimicrobial Susceptibility Studies Source Type: journals

Studies on the influence of esterase inhibitor to the pharmacokinetic profiles of oseltamivir and oseltamivir carboxylate in rats using an improved LC/MS/MS method.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Oseltamivir (O), an ethyl ester prodrug of oseltamivir carboxylate (OC), is currently the drug of choice for avian influenza. Previous studies have found that the addition of esterase inhibitor can inhibit the metabolism of O to OC in plasma samples. The current study aims to evaluate the impact of dichlorvos on the rat plasma concentrations of O and OC and subsequent effect on their pharmacokinetics. The plasma samples of rats after oral administration of O were divided into two equal portions for treatment with/without dichlorvos. O and OC plasma concentrations were analyzed by a sensitive and specific LC/MS/MS metho...
Source: Biomedical Chromatography : BMC - April 7, 2009 Category: Biomedical Science Authors: Chang Q, Chow MS, Zuo Z Tags: Biomed Chromatogr Source Type: journals

Expandase-like activity mediated cell-free conversion of ampicillin to cephalexin by Streptomyces sp. DRS I.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cell-free extracts of Streptomyces sp. DRS I converted ampicillin to cephalexin, presumably due to the activity of the enzyme, expandase. The extract was fractionated and characterized by colorimetric and chromatographic measurements coupled with disc-agar diffusion bioassay against an ampicillin-resistant, cephalexin-sensitive E. coli strain. Though expandase could not be identified, the presence of a hitherto unreported expandase in Streptomyces sp. DRS I is suggested. PMID: 19330490 [PubMed - as supplied by publisher] (Source: Biotechnology Letters)
Source: Biotechnology Letters - March 29, 2009 Category: Biotechnology Authors: Thakur D, Roy MK, Bora TC Tags: Biotechnol Lett Source Type: journals

Activity of ceftobiprole and other cephalosporins against extracellular and intracellular (THP-1 macrophages, keratinocytes) forms of Methicillin-Sensitive (MSSA) and Methicillin-Resistant Staphylococcus aureus (MRSA).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
S. aureus is an opportunistic intracellular organism. Although poorly accumulating in eukaryotic cells, beta-lactams show activity against intracellular MSSA if exposure times and drug concentrations are sufficient. Intraphagocytic MRSA are susceptible to penicillins and carbapenems because acidic pH favors the acylation of PBP 2a by these beta-lactams through pH-induced conformational change. Ceftobiprole, showing almost similar in vitro activities against MRSA and MSSA in broth, was examined for intracellular activity (THP-1 macrophages, keratinocytes) against a panel of hospital-acquired and community-acquired MRSA ...
Source: Antimicrobial Agents and Chemotherapy - March 16, 2009 Category: Microbiology Authors: Lemaire S, Glupczynski Y, Duval V, Joris B, Tulkens PM, Van Bambeke F Tags: Antimicrob Agents Chemother Source Type: journals

Efficacy of Amitraz plus Metaflumizone for the treatment of canine demodicosis associated with Malassezia pachydermatisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This case reports the efficacy of metaflumizone plus amitraz spot-on formulation (ProMeris Duo; Fort Dodge) against generalized demodectic mange. A two year-old male dog presented at clinical examination with poor general condition, diffused alopecia, crusted lesions, pruritus, skin scales and pustules. Demodex mites, Malassezia pachydermatis yeasts and bacteria were diagnosed. The dog was treated with cephalexin and topically with metaflumizone plus amitraz spot-on formulation at two weeks intervals until two consecutive skin scrapings resulted negative for mites. The number of adult mites statistically decreased at follo...
Source: Parasites and Vectors - March 5, 2009 Category: Microbiology Authors: Viviana D Tarallo, Riccardo P Lia, Mariateresa Sasanelli, Claudia Cafarchia and Domenico Otranto Source Type: journals

Rectal prolapse secondary to antibiotic-associated colitis in a dogEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Many animals with rectal prolapse have an antecedent history of dyschezia and tenesmus associated with colonic inflammatory disease. However, it seems that there are no reports of rectal prolapse concurrent with antibiotic-associated colitis in the veterinary literature. A 3-month-old male cross-bred dog presented with a history of recurrent episodes of rectal prolapse following the administration of oral cephalexin. The rectal prolapse was corrected surgically. Based on the dog's recent history of antibiotic use, the sudden onset of bloody diarrhoea, tenesmus and subsequent rectal prolapse, antibio...
Source: Comparative Clinical Pathology - March 4, 2009 Category: Pathology Tags: Comparative Clinical Pathology Source Type: journals

Characteristics and clinical significance of bacterial colonization of ureteral double-J stents in childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Bacterial colonization is not uncommon in double-J stents retained for several weeks after pyeloplasty, but is usually not clinically significant. Enterococcus is the most frequent pathogen. (Source: Journal of Pediatric Urology)
Source: Journal of Pediatric Urology - March 2, 2009 Category: Urology & Nephrology Authors: D. Ben-Meir, S. Golan, Y. Ehrlich, P.M. Livne Source Type: journals

Development and validation of an immunochromatographic assay for rapid multi-residues detection of cephems in milk.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the method was rapid and accurate for the multi-residue detection of cephems in milk. PMID: 19154821 [PubMed - in process] (Source: Analytica Chimica Acta)
Source: Analytica Chimica Acta - January 23, 2009 Category: Chemistry Authors: Xie H, Ma W, Liu L, Chen W, Peng C, Xu C, Wang L Tags: Anal Chim Acta Source Type: journals

Bioavailability and pharmacokinetics of a novel cephalexin oral paste formulation in fed and fasted dogsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Journal of Veterinary Pharmacology and Therapeutics)
Source: Journal of Veterinary Pharmacology and Therapeutics - January 14, 2009 Category: Veterinary Research Authors: A. CHICOINE, W. COX, L. HUANG, G. WANG, P. DOWLING Source Type: journals

Wegmans Food Markets To Offer No-Cost Generic Antibiotics Through MarchEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Wegmans Food Markets starting on Wednesday will fill generic oral antibiotics, such as amoxicillin and cephalexin, at no cost through March 31, the Baltimore Sun reports (Walker, Baltimore Sun, 1/7). The program will run at all of the chain's 72 stores nationwide and will cover up to a 14-day supply of nine generic antibiotics that otherwise would cost between $8.99 and $13.99 without insurance. Colleen Wegman, president of Wegmans, said the company might offer the benefits permanently if the program is successful over the next three months. Wegman estimated that the program would save consumers about $1 million (Wang, Roc...
Source: kaisernetwork.org: Health Policy Daily Report - January 7, 2009 Category: Consumer Health News Tags: Daily Health Policy Report Source Type: news

Management of vagal nerve stimulator infections: do they need to be removed?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions This study confirms the low rate of infection associated with VNS placement and suggests that, in the case of infection, treatment without removal is a viable option. However, the authors' data suggest that oral antibiotics are not the best first-line therapy. PMID: 19119910 [PubMed - in process] (Source: Journal of neurosurgery. Pediatrics)
Source: Journal of neurosurgery. Pediatrics - January 1, 2009 Category: Neurosurgery Authors: Air EL, Ghomri YM, Tyagi R, Grande AW, Crone K, Mangano FT Tags: J Neurosurg Pediatrics Source Type: journals

Management of vagal nerve stimulator infections: do they need to be removed. Clinical article?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: This study confirms the low rate of infection associated with VNS placement and suggests that, in the case of infection, treatment without removal is a viable option. However, the authors' data suggest that oral antibiotics are not the best first-line therapy. PMID: 19119910 [PubMed - in process] (Source: Journal of neurosurgery. Pediatrics)
Source: Journal of neurosurgery. Pediatrics - January 1, 2009 Category: Neurosurgery Authors: Air EL, Ghomri YM, Tyagi R, Grande AW, Crone K, Mangano FT Tags: J Neurosurg Pediatrics Source Type: journals

Preparation and characterization of cephalexin loaded PLGA microspheres.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this study was to evaluate the effects of emulsion type and process parameters on the properties of CPX-loaded PLGA microspheres in order to obtain delivery systems suitable for the treatment of dairy mastitis. The microsphere size was analyzed by photon correlation spectrophotometry. Determination of the drug loading was achieved by HPLC. It was found that CPX-loaded PLGA microspheres prepared using a w/o/w double emulsion technology were slightly larger (approximately 3-5 microm) but much higher in drug content (approximately 18% w/w) than those obtained using o/w single emulsion preparation technology (av...
Source: Current Drug Delivery - January 1, 2009 Category: Drugs & Pharmacology Authors: Chaisri W, Hennink WE, Okonogi S Tags: Curr Drug Deliv Source Type: journals

Kinetic spectrofluorimetric determination of certain cephalosporins in human plasma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An accurate, reliable, specific and sensitive kinetic spectrofluorimetric method was developed for the determination of seven cephalosporin antibiotics namely cefotaxime sodium, cephapirin sodium, cephradine dihydrate, cephalexin monohydrate, cefazoline sodium, ceftriaxone sodium and cefuroxime sodium. The method is based on their degradation under an alkaline condition producing fluorescent products. The factors affecting the degradation and the determination were studied and optimized. The reaction is followed spectrofluorimetrically by measuring the rate of change of fluorescence intensity at specified emission wave...
Source: Talanta - December 18, 2008 Category: Chemistry Authors: Omar MA, Abdelmageed OH, Attia TZ Tags: Talanta Source Type: journals

Board-certified emergency physicians' treatment of skin and soft tissue infections in the community-acquired methicillin-resistant Staphylococcus aureus era.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Many clinicians have changed their practice patterns to include antibiotics that usually display activity against CA-MRSA. However, cephalexin remains a popular agent used for these infections. PMID: 19041536 [PubMed - in process] (Source: The American Journal of Emergency Medicine)
Source: The American Journal of Emergency Medicine - December 3, 2008 Category: Emergency Medicine Authors: Lovecchio F, Perera N, Casanova L, Mulrow M, Pohl A Tags: Am J Emerg Med Source Type: journals

Antibiotic Resistance Patterns of Community-Acquired Urinary Tract Infections in Children With Vesicoureteral Reflux Receiving Prophylactic Antibiotic TherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS. Children receiving cephalosporin prophylaxis are more likely to have extended-spectrum β-lactamase-producing bacteria or multidrug-resistant uropathogens other than E coli for breakthrough urinary tract infections; therefore, these antibiotics are not appropriate for prophylactic use in patients with vesicoureteral reflux. Co-trimoxazole remains the preferred prophylactic agent for vesicoureteral reflux. (Source: PEDIATRICS)
Source: PEDIATRICS - December 1, 2008 Category: Pediatrics Authors: Cheng, C.-H., Tsai, M.-H., Huang, Y.-C., Su, L.-H., Tsau, Y.-K., Lin, C.-J., Chiu, C.-H., Lin, T.-Y. Tags: Infectious Disease & Immunity ARTICLES Source Type: journals

Multifocal papular deep bacterial pyoderma in a Boxer dog caused by Pseudomonas aeruginosa.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A young adult Boxer dog was presented with a papular dermatitis on the dorsal back and ventral neck that had developed while it was being treated with cyclosporine and cephalexin for atopic dermatitis and secondary superficial staphylococcal pyoderma, respectively. Histopathology demonstrated nodular to diffuse pyogranulomatous dermatitis with focal furunculosis. Numerous bacterial rods, free in the tissue and engulfed by neutrophils and macrophages, could be demonstrated on stained samples (haematoxylin-eosin; Giemsa). Bacterial culture from an aseptically collected skin biopsy punch sample yielded a pure growth of Ps...
Source: Australian Veterinary Journal - October 31, 2008 Category: Veterinary Research Authors: Baxter C, Vogelnest Lj Tags: Aust Vet J Source Type: journals

Cephalexin remains preferred oral antibiotic therapy for uncomplicated cellulitis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 18954824 [PubMed - in process] (Source: The American Journal of Medicine)
Source: The American Journal of Medicine - October 30, 2008 Category: Journals (General) Authors: Cunha BA Tags: Am J Med Source Type: journals

Cephalexin(CEPHALEXIN) Capsule Cephalexin(CEPHALEXIN) Suspension [Ranbaxy Pharmaceuticals Inc.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Sep 24, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - September 30, 2008 Category: Drugs & Pharmacology Source Type: organizations

Pharmaceutical contamination in residential, industrial, and agricultural waste streams: Risk to aqueous environments in Taiwan.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This is a comprehensive study of the occurrence of antibiotics, hormones and other pharmaceuticals in water sites that have major potential for downstream environmental contamination. These include residential (hospitals, sewage treatment plants, and regional discharges), industrial (pharmaceutical production facilities), and agricultural (animal husbandries and aquacultures) waste streams. We assayed 23 Taiwanese water sites for 97 targeted compounds, of which a significant number were detected and quantified. The most frequently detected compounds were sulfamethoxazole, caffeine, acetaminophen, and ibuprofen, followe...
Source: Chemosphere - September 29, 2008 Category: Chemistry Authors: Lin AY, Yu TH, Lin CF Tags: Chemosphere Source Type: journals

Influence of cephalosporins on the coagulation time of yogurt made from ewes' milkEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ceftiofur and cephalexin were independently added to ewes' milk at three different concentrations 50, 100 and 150 µg/kg. Spiked milk was used to produce yogurt and the acidification of the yogurt during incubation was then studied. Ceftiofur showed significant delays in the pH decrease rate at all concentrations assayed, but no significant delays occurred with cephalexin. When these antibiotics were administered intramuscularly to lactating ewes, from which the milk was used to make yogurt immediately after the corresponding withdrawal periods, absence of residues and pH delays were not observed during the yogurt fermenta...
Source: International Journal of Dairy Technology - September 15, 2008 Category: Nutrition Authors: MARIA ISABEL BERRUGA, BEATRIZ NOVÉS, MARIA PILAR MOLINA, MARIO ROMÁN, ANA MOLINA Source Type: journals

Management of mastitis in breastfeeding women.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mastitis occurs in approximately 10 percent of U.S. mothers who are breastfeeding, and it can lead to the cessation of breastfeeding. The risk of mastitis can be reduced by frequent, complete emptying of the breast and by optimizing breastfeeding technique. Sore nipples can precipitate mastitis. The differential diagnosis of sore nipples includes mechanical irritation from a poor latch or infant mouth anomalies, such as cleft palate or bacterial or yeast infection. The diagnosis of mastitis is usually clinical, with patients presenting with focal tenderness in one breast accompanied by fever and malaise. Treatment incl...
Source: American Family Physician - September 15, 2008 Category: Primary Care Authors: Spencer JP Tags: Am Fam Physician Source Type: journals

FDA Safety Changes: Viramune, Agrylin, Keflex, Furadantin, MycobutinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The FDA has approved revisions to the safety labeling for nevirapine tablets and oral solution, anagrelide HCl capsules, cephalexin capsules, nitrofurantoin oral suspension, and rifabutin capsules. Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 11, 2008 Category: Consumer Health News Tags: Pharmacist Source Type: news

Cephalexin(Cephalexin) Capsule [Aurobindo Pharma Limited]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Sep 11, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - September 11, 2008 Category: Drugs & Pharmacology Source Type: organizations

Interethnic differences of PEPT2 ( SLC15A2 ) polymorphism distribution and associations with cephalexin pharmacokinetics in healthy Asian subjectsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion PEPT2 polymorphism distributions differ significantly between Chinese, Malay and Asian Indian populations. However, cephalexin pharmacokinetics is not meaningfully different between Chinese and Asian Indians. The association between the PEPT2 haplotype and cephalexin pharmacokinetics could not be confirmed, and future studies under better controlled conditions are needed. Content Type Journal ArticleCategory PharmacogeneticsDOI 10.1007/s00228-008-0488-4Authors Rui Liu, National University of Singapore Department of Pharmacology, Yong Loo Lin School of Medicine Block MD11, Level 5, #05–0...
Source: European Journal of Clinical Pharmacology - September 3, 2008 Category: Drugs & Pharmacology Tags: European Journal of Clinical Pharmacology Source Type: journals

Teratogenicity of antibacterial agents.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of our study was to study the possible correlation between use of antibacterial drugs in pregnancy and occurrence of congenital malformations. Among 6099 investigated pregnant women, 392 (6.43%) used antibacterial drugs. The most frequently used antibacterials belonged to category B (75.77%), while 14.54% antibiotics belonged to category D and 1.02% to category X. The most often used antibiotics were cephalexin (22.19%), amoxicillin (20.66%) and ampicillin (14.29%). In 14 embryos exposed to effects of beta-lactams in utero, malformations were detected. The results of this study show possible teratogenic potenti...
Source: Collegium Antropologicum - September 1, 2008 Category: Epidemiology Authors: Erić M, Sabo A Tags: Coll Antropol Source Type: journals

MiddleBrook Pharmaceuticals narrows lossEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
MiddleBrook Pharmaceuticals Inc. said all revenue last quarter came from sales of its Keflex drug, which treats skin and respiratory tract infections. (MBRK) (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - August 14, 2008 Category: Pharmaceuticals Source Type: journals

Causative agents and antimicrobial susceptibilities of urinary tract infections in the northwest of Iran.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The results show that the antimicrobial resistance patterns of the causes of UTI are highly variable and continuous surveillance of trends in resistance patterns of uropathogens is important. PMID: 18703368 [PubMed - as supplied by publisher] (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - August 12, 2008 Category: Infectious Diseases Authors: Farajnia S, Alikhani MY, Ghotaslou R, Naghili B, Nakhlband A Tags: Int J Infect Dis Source Type: journals

Warfarin With Fluoroquinolones, Sulfonamides, or Azole Antifungals: Interactions and the Risk of Hospitalization for Gastrointestinal Bleeding.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this study was to determine whether a potential pharmacokinetic interaction between warfarin and orally administered anti-infectives increases the risk of hospitalization for gastrointestinal (GI) bleeding in warfarin users. We conducted a nested case-control and case-crossover study using US Medicaid data. Logistic regression was used to determine the association between GI bleeding and prior use of ciprofloxacin, levofloxacin, gatifloxacin, co-trimoxazole, or fluconazole vs. no exposure and also vs. use of cephalexin, which would not be expected to interact with warfarin. All of the anti-infectives examine...
Source: Clinical Pharmacology and Therapeutics - August 6, 2008 Category: Drugs & Pharmacology Authors: Schelleman H, Bilker W, Brensinger C, Han X, Kimmel S, Hennessy S Tags: Clin Pharmacol Ther Source Type: journals

Synthesis of Cephalexin in Aqueous Medium with Carrier-bound and Carrier-free Penicillin Acylase Biocatalysts.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The use of very high substrate concentrations favors the kinetically controlled synthesis of cephalexin with penicillin acylase (PA) not only by Michaelian considerations, but also because water activity is depressed, so reducing the rates of the competing reactions of product and acyl donor hydrolysis. Commercial PGA-450, glyoxyl agarose immobilized (PAIGA) and carrier-free cross-linked enzyme aggregates of penicillin acylase (PACLEA) were tested in aqueous media at concentrations close to the solubility of nucleophile and at previously determined enzyme to nucleophile and acid donor to nucleophile ratios. The best te...
Source: Applied Biochemistry and Biotechnology - July 10, 2008 Category: Biochemistry Authors: Illanes A, Wilson L, Aguirre C Tags: Appl Biochem Biotechnol Source Type: journals