The Role of Verbal Fluency in the Cerebellar Cognitive Affective Syndrome Scale in Friedreich Ataxia
This study explored the relationship between performance on the CCAS-S and clinical metrics of disease severity in 57 adults with FRDA. In addition, this study explored the relationship between measures of intelligibility and naturalness of speech and scores on the CCAS-S in a subgroup of 39 individuals with FRDA. We demonstrated a significant relationship between clinical metrics and performance on the CCAS-S. In addition, we confirmed the items that returned the greatest rate of failure were based on Verbal Fluency Tasks, revealing a significant relationship between these items and measures of speech. Measures of speech ...
Source: Cerebellum - April 20, 2024 Category: Neuroscience Authors: Louise A Corben Eliza Blomfield Geneieve Tai Hiba Bilal Ian H Harding Nellie Georgiou-Karistianis Martin B Delatycki Adam P Vogel Source Type: research
The Role of Cognitive Reserve in Protecting Cerebellar Volumes of Older Adults with mild Cognitive Impairment
This study suggests that a higher cognitive reserve is associated with specific cerebellar lobule volumes and that Working activity may play a predominant role in this association. These findings contribute to the understanding of the relationship between cerebellar volumes and cognitive reserve, highlighting the potential modulatory role of Working activity on cerebellum response to cognitive decline.PMID:38639874 | DOI:10.1007/s12311-024-01695-w (Source: Cerebellum)
Source: Cerebellum - April 19, 2024 Category: Neuroscience Authors: Maria Devita Giulia Debiasi Mariagiulia Anglani Chiara Ceolin Ilaria Mazzonetto Chiara Begliomini Simone Cauzzo Cecilia Raffaelli Alessandro Lazzarin Adele Ravelli Alessandra Bordignon Marina De Rui Giuseppe Sergi Alessandra Bertoldo Daniela Mapelli Aless Source Type: research
Role of the Cerebellum in the Construction of Functional and Geometrical Spaces
Cerebellum. 2024 Apr 16. doi: 10.1007/s12311-024-01693-y. Online ahead of print.ABSTRACTThe perceptual and motor systems appear to have a set of movement primitives that exhibit certain geometric and kinematic invariances. Complex patterns and mental representations can be produced by (re)combining some simple motor elements in various ways using basic operations, transformations, and respecting a set of laws referred to as kinematic laws of motion. For example, point-to-point hand movements are characterized by straight hand paths with single-peaked-bell-shaped velocity profiles, whereas hand speed profiles for curved tra...
Source: Cerebellum - April 16, 2024 Category: Neuroscience Authors: Eya Torkhani Langlois Daniel Bennequin Giovanni de Marco Source Type: research
Role of the Cerebellum in the Construction of Functional and Geometrical Spaces
Cerebellum. 2024 Apr 16. doi: 10.1007/s12311-024-01693-y. Online ahead of print.ABSTRACTThe perceptual and motor systems appear to have a set of movement primitives that exhibit certain geometric and kinematic invariances. Complex patterns and mental representations can be produced by (re)combining some simple motor elements in various ways using basic operations, transformations, and respecting a set of laws referred to as kinematic laws of motion. For example, point-to-point hand movements are characterized by straight hand paths with single-peaked-bell-shaped velocity profiles, whereas hand speed profiles for curved tra...
Source: Cerebellum - April 16, 2024 Category: Neuroscience Authors: Eya Torkhani Langlois Daniel Bennequin Giovanni de Marco Source Type: research
Role of the Cerebellum in the Construction of Functional and Geometrical Spaces
Cerebellum. 2024 Apr 16. doi: 10.1007/s12311-024-01693-y. Online ahead of print.ABSTRACTThe perceptual and motor systems appear to have a set of movement primitives that exhibit certain geometric and kinematic invariances. Complex patterns and mental representations can be produced by (re)combining some simple motor elements in various ways using basic operations, transformations, and respecting a set of laws referred to as kinematic laws of motion. For example, point-to-point hand movements are characterized by straight hand paths with single-peaked-bell-shaped velocity profiles, whereas hand speed profiles for curved tra...
Source: Cerebellum - April 16, 2024 Category: Neuroscience Authors: Eya Torkhani Langlois Daniel Bennequin Giovanni de Marco Source Type: research
Evaluation of the Patients with the Diagnosis of Pontocerebellar Hypoplasia: A Multicenter National Study
Cerebellum. 2024 Apr 15. doi: 10.1007/s12311-024-01690-1. Online ahead of print.ABSTRACTPontocerebellar hypoplasia (PCH) is a heterogeneous group of neurodegenerative disorders characterized by hypoplasia and degeneration of the cerebellum and pons. We aimed to identify the clinical, laboratory, and imaging findings of the patients with diagnosed PCH with confirmed genetic analysis. We collected available clinical data, laboratory, and imaging findings in our retrospective multicenter national study of 64 patients with PCH in Turkey. The genetic analysis included the whole-exome sequencing (WES), targeted next-generation s...
Source: Cerebellum - April 15, 2024 Category: Neuroscience Authors: Dilek Cavusoglu Gulten Ozturk Dilsad Turkdogan Semra Hiz Kurul Uluc Yis Mustafa Komur Faruk Incecik Bulent Kara Turkan Sahin Olcay Unver Cengiz Dilber Gulen Gul Mert Cagatay Gunay Gamze Sarikaya Uzan Ozlem Ersoy Yavuz Oktay Serdar Mermer Gokcen Oz Tuncer Source Type: research
Evaluation of the Patients with the Diagnosis of Pontocerebellar Hypoplasia: A Multicenter National Study
Cerebellum. 2024 Apr 15. doi: 10.1007/s12311-024-01690-1. Online ahead of print.ABSTRACTPontocerebellar hypoplasia (PCH) is a heterogeneous group of neurodegenerative disorders characterized by hypoplasia and degeneration of the cerebellum and pons. We aimed to identify the clinical, laboratory, and imaging findings of the patients with diagnosed PCH with confirmed genetic analysis. We collected available clinical data, laboratory, and imaging findings in our retrospective multicenter national study of 64 patients with PCH in Turkey. The genetic analysis included the whole-exome sequencing (WES), targeted next-generation s...
Source: Cerebellum - April 15, 2024 Category: Neuroscience Authors: Dilek Cavusoglu Gulten Ozturk Dilsad Turkdogan Semra Hiz Kurul Uluc Yis Mustafa Komur Faruk Incecik Bulent Kara Turkan Sahin Olcay Unver Cengiz Dilber Gulen Gul Mert Cagatay Gunay Gamze Sarikaya Uzan Ozlem Ersoy Yavuz Oktay Serdar Mermer Gokcen Oz Tuncer Source Type: research
Prenatal Diagnosis of Cerebellar Cortical Dysplasia: Case Report
Cerebellum. 2024 Apr 12. doi: 10.1007/s12311-024-01688-9. Online ahead of print.ABSTRACTThis was a study of 12 cerebellar cortical dysplasias (CCDs) fetuses, these cases were characterized by a disorder of cerebellar fissures. Historically, CCD diagnosis was primarily performed using postnatal imaging. Unique to this study was the case series of CCD for prenatal diagnosis using prenatal ultrasound, as well as we found that AXIN1 and FOXC1 mutations may be related to CCD.PMID:38607531 | DOI:10.1007/s12311-024-01688-9 (Source: Cerebellum)
Source: Cerebellum - April 12, 2024 Category: Neuroscience Authors: Yan Ding Zhixuan Chen Huaxuan Wen Dandan Luo Ying Yuan Shaojun Zhang Xiaohong Zhong Shengli Li Source Type: research
Prenatal Diagnosis of Cerebellar Cortical Dysplasia: Case Report
Cerebellum. 2024 Apr 12. doi: 10.1007/s12311-024-01688-9. Online ahead of print.ABSTRACTThis was a study of 12 cerebellar cortical dysplasias (CCDs) fetuses, these cases were characterized by a disorder of cerebellar fissures. Historically, CCD diagnosis was primarily performed using postnatal imaging. Unique to this study was the case series of CCD for prenatal diagnosis using prenatal ultrasound, as well as we found that AXIN1 and FOXC1 mutations may be related to CCD.PMID:38607531 | DOI:10.1007/s12311-024-01688-9 (Source: Cerebellum)
Source: Cerebellum - April 12, 2024 Category: Neuroscience Authors: Yan Ding Zhixuan Chen Huaxuan Wen Dandan Luo Ying Yuan Shaojun Zhang Xiaohong Zhong Shengli Li Source Type: research
Preterm Birth Alters the Regional Development and Structural Covariance of Cerebellum at Term-Equivalent Age
In this study, using the structural MR images of 52 preterm infants scanned at term-equivalent age and 312 full-term controls from the Developing Human Connectome Project, we compared volumetric growth, local cerebellum shape development and cerebello-cerebral structural covariance between the two groups. We found that although there was no significant difference in the overall volume measurements between preterm and full-term infants, the shape measurements were different. Compared with the control infants, preterm infants had significantly larger thickness in the vermis and lower thickness in the lateral portions of the ...
Source: Cerebellum - April 6, 2024 Category: Neuroscience Authors: Feifei Xu Yu Wang Wenjun Wang Wenjia Liang Yuchun Tang Shuwei Liu Source Type: research
Preterm Birth Alters the Regional Development and Structural Covariance of Cerebellum at Term-Equivalent Age
In this study, using the structural MR images of 52 preterm infants scanned at term-equivalent age and 312 full-term controls from the Developing Human Connectome Project, we compared volumetric growth, local cerebellum shape development and cerebello-cerebral structural covariance between the two groups. We found that although there was no significant difference in the overall volume measurements between preterm and full-term infants, the shape measurements were different. Compared with the control infants, preterm infants had significantly larger thickness in the vermis and lower thickness in the lateral portions of the ...
Source: Cerebellum - April 6, 2024 Category: Neuroscience Authors: Feifei Xu Yu Wang Wenjun Wang Wenjia Liang Yuchun Tang Shuwei Liu Source Type: research
Preterm Birth Alters the Regional Development and Structural Covariance of Cerebellum at Term-Equivalent Age
In this study, using the structural MR images of 52 preterm infants scanned at term-equivalent age and 312 full-term controls from the Developing Human Connectome Project, we compared volumetric growth, local cerebellum shape development and cerebello-cerebral structural covariance between the two groups. We found that although there was no significant difference in the overall volume measurements between preterm and full-term infants, the shape measurements were different. Compared with the control infants, preterm infants had significantly larger thickness in the vermis and lower thickness in the lateral portions of the ...
Source: Cerebellum - April 6, 2024 Category: Neuroscience Authors: Feifei Xu Yu Wang Wenjun Wang Wenjia Liang Yuchun Tang Shuwei Liu Source Type: research
Preterm Birth Alters the Regional Development and Structural Covariance of Cerebellum at Term-Equivalent Age
In this study, using the structural MR images of 52 preterm infants scanned at term-equivalent age and 312 full-term controls from the Developing Human Connectome Project, we compared volumetric growth, local cerebellum shape development and cerebello-cerebral structural covariance between the two groups. We found that although there was no significant difference in the overall volume measurements between preterm and full-term infants, the shape measurements were different. Compared with the control infants, preterm infants had significantly larger thickness in the vermis and lower thickness in the lateral portions of the ...
Source: Cerebellum - April 6, 2024 Category: Neuroscience Authors: Feifei Xu Yu Wang Wenjun Wang Wenjia Liang Yuchun Tang Shuwei Liu Source Type: research
Preterm Birth Alters the Regional Development and Structural Covariance of Cerebellum at Term-Equivalent Age
In this study, using the structural MR images of 52 preterm infants scanned at term-equivalent age and 312 full-term controls from the Developing Human Connectome Project, we compared volumetric growth, local cerebellum shape development and cerebello-cerebral structural covariance between the two groups. We found that although there was no significant difference in the overall volume measurements between preterm and full-term infants, the shape measurements were different. Compared with the control infants, preterm infants had significantly larger thickness in the vermis and lower thickness in the lateral portions of the ...
Source: Cerebellum - April 6, 2024 Category: Neuroscience Authors: Feifei Xu Yu Wang Wenjun Wang Wenjia Liang Yuchun Tang Shuwei Liu Source Type: research
Effect of Regional Brain Activity Following Repeat Transcranial Magnetic Stimulation in SCA3: A Secondary Analysis of a Randomized Clinical Trial
This study aims to observe the short-term impact of cerebellar rTMS on motor function in SCA3 patients and utilize resting-state functional magnetic resonance imaging (RS-fMRI) to assess potential therapeutic mechanisms. Twenty-two SCA3 patients were randomly assigned to receive actual rTMS (AC group, n = 11, three men and eight women; age 32-55 years) or sham rTMS (SH group, n = 11, three men and eight women; age 26-58 years). Both groups underwent cerebellar rTMS or sham rTMS daily for 15 days. The primary outcome measured was the ICARS scores and parameters for regional brain activity. Compared to baseline, ICARS scores...
Source: Cerebellum - April 1, 2024 Category: Neuroscience Authors: Xia Liu Lin Zhang Hao-Lin Xu Xia-Hua Liu Arif Sikandar Meng-Cheng Li Xiao-Yue Xia Zi-Qiang Huang Na-Ping Chen Yu-Qing Tu Jian-Ping Hu Shi-Rui Gan Qun-Lin Chen Xin-Yuan Chen Shi-Zhong Wang Members of the Organization in South-East China for Cerebellar Atax Source Type: research
