Cognitive decline, A β pathology, and blood–brain barrier function in aged 5xFAD mice
Patients with Alzheimer's disease (AD) develop blood –brain barrier dysfunction to varying degrees. How aging impacts Aβ pathology, blood–brain barrier function, and cognitive decline in AD remains largely unkn... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - March 27, 2024 Category: Neurology Authors: Geetika Nehra, Sasivimon Promsan, Ruedeemars Yubolphan, Wijitra Chumboatong, Pornpun Vivithanaporn, Bryan J. Maloney, Anusorn Lungkaphin, Bjoern Bauer and Anika M. S. Hartz Tags: Research Source Type: research

Role of aquaporin-4 polarization in extracellular solute clearance
Waste from the brain has been shown to be cleared via the perivascular spaces through the so-called glymphatic system. According to this model the cerebrospinal fluid (CSF) enters the brain in perivascular spa... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - March 26, 2024 Category: Neurology Authors: Laura Bojarskaite, Sahar Nafari, Anne Katrine Ravnanger, Mina Martine Frey, Nadia Skauli, Knut Sindre Åbjørsbråten, Lena Catherine Roth, Mahmood Amiry-Moghaddam, Erlend A. Nagelhus, Ole Petter Ottersen, Inger Lise Bogen, Anna E. Thoren and Rune Enger Tags: Brief Report Source Type: research

Abcg2a is the functional homolog of human ABCG2 expressed at the zebrafish blood –brain barrier
A principal protective component of the mammalian blood –brain barrier (BBB) is the high expression of the multidrug efflux transporters P-glycoprotein (P-gp, encoded by ABCB1) and ABCG2 (encoded by ABCG2) on the ... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - March 15, 2024 Category: Neurology Authors: Joanna R. Thomas, William J. E. Frye, Robert W. Robey, Andrew C. Warner, Donna Butcher, Jennifer L. Matta, Tamara C. Morgan, Elijah F. Edmondson, Paula B. Salazar, Suresh V. Ambudkar and Michael M. Gottesman Tags: Research Source Type: research

Transient but not chronic hyperglycemia accelerates ocular glymphatic transport
Glymphatic transport is vital for the physiological homeostasis of the retina and optic nerve. Pathological alterations of ocular glymphatic fluid transport and enlarged perivascular spaces have been described... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - March 12, 2024 Category: Neurology Authors: Christine Delle, Xiaowei Wang, Michael Giannetto, Evan Newbold, Weiguo Peng, Ryszard Stefan Gomolka, Antonio Ladr ón-de-Guevara, Neža Cankar, Elise Schiøler Nielsen, Celia Kjaerby, Pia Weikop, Yuki Mori and Maiken Nedergaard Tags: Research Source Type: research

Freezing of gait in idiopathic normal pressure hydrocephalus
This study ’s objective was to evaluate the frequency of FoG in a large cohort of iNPH pati... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - March 8, 2024 Category: Neurology Authors: Carl-Johan Kihlstedt, Jan Malm, Alfonso Fasano and David B äckström Tags: Research Source Type: research

Validating the accuracy of real-time phase-contrast MRI and quantifying the effects of free breathing on cerebrospinal fluid dynamics
Understanding of the cerebrospinal fluid (CSF) circulation is essential for physiological studies and clinical diagnosis. Real-time phase contrast sequences (RT-PC) can quantify beat-to-beat CSF flow signals. ... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - March 7, 2024 Category: Neurology Authors: Pan Liu, Kimi Owashi, Heimiri Monnier, Serge Metanbou, Cyrille Capel and Olivier Bal édent Tags: Research Source Type: research

The genetic basis of hydrocephalus: genes, pathways, mechanisms, and global impact
Hydrocephalus (HC) is a heterogenous disease characterized by alterations in cerebrospinal fluid (CSF) dynamics that may cause increased intracranial pressure. HC is a component of a wide array of genetic synd... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - March 4, 2024 Category: Neurology Authors: Andrew T. Hale, Hunter Boudreau, Rishi Devulapalli, Phan Q. Duy, Travis J. Atchley, Michael C. Dewan, Mubeen Goolam, Graham Fieggen, Heather L. Spader, Anastasia A. Smith, Jeffrey P. Blount, James M. Johnston, Brandon G. Rocque, Curtis J. Rozzelle, Zechen Tags: Review Source Type: research

The proteome of the blood –brain barrier in rat and mouse: highly specific identification of proteins on the luminal surface of brain microvessels by in vivo glycocapture
The active transport of molecules into the brain from blood is regulated by receptors, transporters, and other cell surface proteins that are present on the luminal surface of endothelial cells at the blood –br... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - March 4, 2024 Category: Neurology Authors: Tammy-Lynn Tremblay, Wael Alata, Jacqueline Slinn, Ewa Baumann, Christie E. Delaney, Maria Moreno, Arsalan S. Haqqani, Danica B. Stanimirovic and Jennifer J. Hill Tags: Research Source Type: research

Deep learning segmentation of the choroid plexus from structural magnetic resonance imaging (MRI): validation and normative ranges across the adult lifespan
The choroid plexus functions as the blood-cerebrospinal fluid (CSF) barrier, plays an important role in CSF production and circulation, and has gained increased attention in light of the recent elucidation of ... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - February 29, 2024 Category: Neurology Authors: Jarrod J. Eisma, Colin D. McKnight, Kilian Hett, Jason Elenberger, Caleb J. Han, Alexander K. Song, Ciaran Considine, Daniel O. Claassen and Manus J. Donahue Tags: Research Source Type: research

Large-scale in-silico analysis of CSF dynamics within the subarachnoid space of the optic nerve
Impaired cerebrospinal fluid (CSF) dynamics is involved in the pathophysiology of neurodegenerative diseases of the central nervous system and the optic nerve (ON), including Alzheimer ’s and Parkinson’s diseas... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - February 28, 2024 Category: Neurology Authors: Diego Rossinelli, Gilles Fourestey, Hanspeter Esriel Killer, Albert Neutzner, Gianluca Iaccarino, Luca Remonda and Jatta Berberat Tags: Research Source Type: research

Investigating post-traumatic syringomyelia and local fluid osmoregulation via a rat model
Syringomyelia (SM) is characterized by the development of fluid-filled cavities, referred to as syrinxes, within the spinal cord tissue. The molecular etiology of SM post-spinal cord injury (SCI) is not well u... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - February 26, 2024 Category: Neurology Authors: Dipak D. Pukale, Kayla Adkins-Travis, Siddhartha R. Aryal, Leah P. Shriver, Gary J. Patti and Nic D. Leipzig Tags: Research Source Type: research

Pro-inflammatory cerebrospinal fluid profile of neonates with intraventricular hemorrhage: clinical relevance and contrast with CNS infection
Interpretation of cerebrospinal fluid (CSF) studies can be challenging in preterm infants. We hypothesized that intraventricular hemorrhage (IVH), post-hemorrhagic hydrocephalus (PHH), and infection (meningiti... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - February 21, 2024 Category: Neurology Authors: Maria Garcia-Bonilla, Alexander T. Yahanda, Albert M. Isaacs, Brandon Baksh, S. Hassan A. Akbari, Haley Botteron, Diego M. Morales, Rowland H. Han, James P. McAllister II, Amit M. Mathur, Jennifer M. Strahle, Christopher D. Smyser and David D. Limbrick Jr Tags: Research Source Type: research

Endothelial and mural laminin- α5 contributes to neurovascular integrity maintenance
Laminin- α5, a major component of the basal lamina, is predominantly synthesized by endothelial and mural cells (pericytes and vascular smooth muscle cells) in the CNS. Loss of laminin-α5 in either population f... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - February 21, 2024 Category: Neurology Authors: Abhijit Nirwane, Minkyung Kang, Aravinthan Adithan, Vrishni Maharaj, Felicia Nguyen, Elliot Santaella Aguilar, Ava Nasrollahi and Yao Yao Tags: Research Source Type: research

Cerebrospinal fluid shunt surgery reduces the risk of developing dementia and Alzheimer ’s disease in patients with idiopathic normal pressure hydrocephalus: a nationwide population-based propensity-weighted cohort study
Patients with idiopathic normal-pressure hydrocephalus (iNPH) are predisposed to developing dementing disorders. Cerebrospinal fluid (CSF) shunt implantation is a treatment used to improve the motor and cognit... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - February 14, 2024 Category: Neurology Authors: Pao-Hui Tseng, Wan-Ting Huang, Jen-Hung Wang, Bor-Ren Huang, Hsin-Yi Huang and Sheng-Tzung Tsai Tags: Research Source Type: research

Mass spectrometry-based proteomics of cerebrospinal fluid in pediatric central nervous system malignancies: a systematic review with meta-analysis of individual patient data
The cerebrospinal fluid (CSF) proteome could offer important insights into central nervous system (CNS) malignancies. To advance proteomic research in pediatric CNS cancer, the current study aims to (1) evalua... (Source: Cerebrospinal Fluid Research)
Source: Cerebrospinal Fluid Research - February 13, 2024 Category: Neurology Authors: Christian Mirian, Maria Thastrup, Ren é Mathiasen, Kjeld Schmiegelow, Jesper Velgaard Olsen and Ole Østergaard Tags: Review Source Type: research