Dynamic duo: Kir6 and SUR in K < sub > ATP < /sub > channel structure and function
Channels (Austin). 2024 Dec;18(1):2327708. doi: 10.1080/19336950.2024.2327708. Epub 2024 Mar 15.ABSTRACTKATP channels are ligand-gated potassium channels that couple cellular energetics with membrane potential to regulate cell activity. Each channel is an eight subunit complex comprising four central pore-forming Kir6 inward rectifier potassium channel subunits surrounded by four regulatory subunits known as the sulfonylurea receptor, SUR, which confer homeostatic metabolic control of KATP gating. SUR is an ATP binding cassette (ABC) protein family homolog that lacks membrane transport activity but is essential for KATP ex...
Source: Channels - March 15, 2024 Category: Molecular Biology Authors: Bruce L Patton Phillip Zhu Assmaa ElSheikh Camden M Driggers Show-Ling Shyng Source Type: research

Dynamic duo: Kir6 and SUR in K < sub > ATP < /sub > channel structure and function
Channels (Austin). 2024 Dec;18(1):2327708. doi: 10.1080/19336950.2024.2327708. Epub 2024 Mar 15.ABSTRACTKATP channels are ligand-gated potassium channels that couple cellular energetics with membrane potential to regulate cell activity. Each channel is an eight subunit complex comprising four central pore-forming Kir6 inward rectifier potassium channel subunits surrounded by four regulatory subunits known as the sulfonylurea receptor, SUR, which confer homeostatic metabolic control of KATP gating. SUR is an ATP binding cassette (ABC) protein family homolog that lacks membrane transport activity but is essential for KATP ex...
Source: Channels - March 15, 2024 Category: Molecular Biology Authors: Bruce L Patton Phillip Zhu Assmaa ElSheikh Camden M Driggers Show-Ling Shyng Source Type: research

Structural modeling of ion channels using AlphaFold2, RoseTTAFold2, and ESMFold
Channels (Austin). 2024 Dec;18(1):2325032. doi: 10.1080/19336950.2024.2325032. Epub 2024 Mar 6.ABSTRACTIon channels play key roles in human physiology and are important targets in drug discovery. The atomic-scale structures of ion channels provide invaluable insights into a fundamental understanding of the molecular mechanisms of channel gating and modulation. Recent breakthroughs in deep learning-based computational methods, such as AlphaFold, RoseTTAFold, and ESMFold have transformed research in protein structure prediction and design. We review the application of AlphaFold, RoseTTAFold, and ESMFold to structural modelin...
Source: Channels - March 6, 2024 Category: Molecular Biology Authors: Phuong Tran Nguyen Brandon John Harris Diego Lopez Mateos Adriana Hern ández González Adam Michael Murray Vladimir Yarov-Yarovoy Source Type: research

Structural modeling of ion channels using AlphaFold2, RoseTTAFold2, and ESMFold
Channels (Austin). 2024 Dec;18(1):2325032. doi: 10.1080/19336950.2024.2325032. Epub 2024 Mar 6.ABSTRACTIon channels play key roles in human physiology and are important targets in drug discovery. The atomic-scale structures of ion channels provide invaluable insights into a fundamental understanding of the molecular mechanisms of channel gating and modulation. Recent breakthroughs in deep learning-based computational methods, such as AlphaFold, RoseTTAFold, and ESMFold have transformed research in protein structure prediction and design. We review the application of AlphaFold, RoseTTAFold, and ESMFold to structural modelin...
Source: Channels - March 6, 2024 Category: Molecular Biology Authors: Phuong Tran Nguyen Brandon John Harris Diego Lopez Mateos Adriana Hern ández González Adam Michael Murray Vladimir Yarov-Yarovoy Source Type: research