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571 records returned

Inside Cover: A Fragment-Based Approach to Probing Adenosine Recognition Sites by Using Dynamic Combinatorial Chemistry (ChemBioChem 17/2009).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19921671 [PubMed - as supplied by publisher] (Source: Chembiochem)
Source: Chembiochem - November 17, 2009 Category: Biochemistry Authors: Scott DE, Dawes GJ, Ando M, Abell C, Ciulli A Tags: Chembiochem Source Type: journals

Delivery of Therapeutic RNAi by Nanovehicles.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19921672 [PubMed - as supplied by publisher] (Source: Chembiochem)
Source: Chembiochem - November 17, 2009 Category: Biochemistry Authors: Baigude H, Rana TM Tags: Chembiochem Source Type: journals

Spotlights on our sister journals: ChemBioChem 17/2009.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Authors: PMID: 19921673 [PubMed - as supplied by publisher] (Source: Chembiochem)
Source: Chembiochem - November 17, 2009 Category: Biochemistry Tags: Chembiochem Source Type: journals

Preview: ChemBioChem 18/2009.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Authors: PMID: 19921674 [PubMed - as supplied by publisher] (Source: Chembiochem)
Source: Chembiochem - November 17, 2009 Category: Biochemistry Tags: Chembiochem Source Type: journals

Five-Component Cascade Synthesis of Nucleotide Analogues in an Engineered Self-Immobilized Enzyme Aggregate.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19918830 [PubMed - as supplied by publisher] (Source: Chembiochem)
Source: Chembiochem - November 13, 2009 Category: Biochemistry Authors: Scism RA, Bachmann BO Tags: Chembiochem Source Type: journals

Principles and Applications of the Photochemical Control of Cellular Processes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19911402 [PubMed - as supplied by publisher] (Source: Chembiochem)
Source: Chembiochem - November 12, 2009 Category: Biochemistry Authors: Deiters A Tags: Chembiochem Source Type: journals

Covalent-Bond-Based Immobilization Approaches for Single-Molecule Fluorescence.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19911404 [PubMed - as supplied by publisher] (Source: Chembiochem)
Source: Chembiochem - November 12, 2009 Category: Biochemistry Authors: Alemán EA, Pedini HS, Rueda D Tags: Chembiochem Source Type: journals

New Ways of Killing the Beast: Prospects for Inorganic-Organic Hybrid Nanomaterials as Antibacterial Agents.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19904793 [PubMed - as supplied by publisher] (Source: Chembiochem)
Source: Chembiochem - November 10, 2009 Category: Biochemistry Authors: Bandow JE, Metzler-Nolte N Tags: Chembiochem Source Type: journals

Enzymatic Incorporation of Multiple Dyes for Increased Sensitivity in QD-FRET Sensing for DNA Methylation Detection.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19904794 [PubMed - as supplied by publisher] (Source: Chembiochem)
Source: Chembiochem - November 10, 2009 Category: Biochemistry Authors: Bailey VJ, Keeley BP, Zhang Y, Ho YP, Easwaran H, Brock MV, Pelosky KL, Carraway HE, Baylin SB, Herman JG, Wang TH Tags: Chembiochem Source Type: journals

Novel 3'-O-Fluorescently Modified Nucleotides for Reversible Termination of DNA Synthesis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19904795 [PubMed - as supplied by publisher] (Source: Chembiochem)
Source: Chembiochem - November 10, 2009 Category: Biochemistry Authors: Kim TS, Kim DR, Ahn HC, Shin D, Ahn DR Tags: Chembiochem Source Type: journals

Exploring the Substrate Promiscuity of Drug-Modifying Enzymes for the Chemoenzymatic Generation of N-Acylated Aminoglycosides.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aminoglycosides are broad-spectrum antibiotics commonly used for the treatment of serious bacterial infections. Decades of clinical use have led to the widespread emergence of bacterial resistance to this family of drugs limiting their efficacy in the clinic. Here, we report the development of a methodology that utilizes aminoglycoside acetyltransferases (AACs) and unnatural acyl coenzyme A analogues for the chemoenzymatic generation of N-acylated aminoglycoside analogues. Generation of N-acylated aminoglycosides is followed by a simple qualitative test to assess their potency as potential antibacterials. The studied A...
Source: Chembiochem - November 6, 2009 Category: Biochemistry Authors: Green KD, Chen W, Houghton JL, Fridman M, Garneau-Tsodikova S Tags: Chembiochem Source Type: journals

Synthesis of Threefold Glycosylated Proteins using Click Chemistry and Genetically Encoded Unnatural Amino Acids.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19899090 [PubMed - as supplied by publisher] (Source: Chembiochem)
Source: Chembiochem - November 6, 2009 Category: Biochemistry Authors: Kaya E, Gutsmiedl K, Vrabel M, Müller M, Thumbs P, Carell T Tags: Chembiochem Source Type: journals

Wall Teichoic Acid Function, Biosynthesis, and Inhibition.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19899094 [PubMed - as supplied by publisher] (Source: Chembiochem)
Source: Chembiochem - November 6, 2009 Category: Biochemistry Authors: Swoboda JG, Campbell J, Meredith TC, Walker S Tags: Chembiochem Source Type: journals

Computational Study of the Lipase-Mediated Desymmetrisation of 2-Substituted-Propane-1,3-Diamines.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The enantioselectivity displayed by the lipase from Pseudomonas cepacia towards a wide range of prochiral 2-substituted-propane-1,3-diamines was studied by means of molecular dynamics simulations (MDS). In all cases the enzyme allows the recovery of the corresponding amino carbamates of R configuration. However, the enantioselectivity is only synthetically useful if no ortho substituent is present and the aromatic ring is directly bonded to the 2-carbon of the 1,3-diamine core. Analysis of the MDS trajectories revealed that the homologation of 2-aryl substituents by means of a methylene group lowers enantioselectivity ...
Source: Chembiochem - November 2, 2009 Category: Biochemistry Authors: García-Urdiales E, Busto E, Ríos-Lombardía N, Gotor-Fernández V, Gotor V Tags: Chembiochem Source Type: journals

Diarylpropane-1,3-dione Derivatives as TetR-Inducing Tetracycline Mimetics: Synthesis and Biological Investigations.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Synthesis, biological investigations and molecular docking studies of nonantibiotic and nontetracyclic inducers that feature a minimal key motif of the natural lead tetracycline are presented. The diarylpropane-1,3-dione motif was identified as the minimal substructure responsible for TetR induction by tetracyclines. The first nontetracyclic surrogates of the natural tetracyclines displayed significant inducing effects for TetR(BD)S135L, whereby the chlorohydroxyphenyl-substituted beta-diketone 31 displayed the highest activity. Interestingly, antibiotic activity could not be detected for 31. Homology modeling based on...
Source: Chembiochem - November 2, 2009 Category: Biochemistry Authors: Kormann C, Pimenta I, Löber S, Wimmer C, Lanig H, Clark T, Hillen W, Gmeiner P Tags: Chembiochem Source Type: journals

A Conserved Lysine in beta-Lactam Synthetase Assists Ring Cyclization: Implications for Clavam and Carbapenem Biosynthesis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
beta-Lactam synthetase (beta-LS) is the paradigm of a growing class of enzymes that form the critical beta-lactam ring in the clavam and carbapenem antibiotics. beta-LS catalyzes a two-stage reaction in which N(2)-(2-carboxyethyl)-L-arginine is first adenylated, and then undergoes intramolecular ring closure. It was previously shown that the forward kinetic commitment to beta-lactam formation is high, and that the overall rate of reaction is partially limited to a protein conformational change rather than to the chemical step alone of closing the strained ring. beta-Lactam formation was evaluated on the basis of X-ray ...
Source: Chembiochem - October 30, 2009 Category: Biochemistry Authors: Raber ML, Castillo A, Greer A, Townsend CA Tags: Chembiochem Source Type: journals

Copper and Zinc Binding to Amyloid-beta: Coordination, Dynamics, Aggregation, Reactivity and Metal-Ion Transfer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The metal ions copper, zinc and iron have been shown to be involved in Alzheimer's disease (AD). Cu, Zn and Fe ions are proposed to be implicated in two key steps of AD pathology: 1) aggregation of the peptide amyloid-beta (Abeta), and 2) production of reactive oxygen species (ROS) induced by Abeta. There is compelling evidence that Cu and Zn bind directly to Abeta in AD. This formation of Cu/Zn-Abeta complexes is thought to be aberrant as they have been detected only in AD, but not under healthy conditions. In this context, the understanding of how these metal ions interact with Abeta, their influence on structure and...
Source: Chembiochem - October 28, 2009 Category: Biochemistry Authors: Faller P Tags: Chembiochem Source Type: journals

Interactions of KLA Amphipathic Model Peptides with Lipid Monolayers.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Interactions of the cationic amphipathic peptide KLALKLALKALKAALKLA-NH(2) (KLAL) and its double D-amino acid replacement analogues l(11)k(12)-KLAL and k(9)a(10)-KLAL with lipid monolayers of anionic POPG, zwitterionic POPC and mixtures thereof at the air/water interface were investigated by infrared reflection- absorption spectroscopy (IRRAS). At high surface pressure (>30 mN m(-1)) all peptides incorporated into lipid monolayers containing at least 25 % anionic POPG, and adopted an alpha-helical conformation. Creation of free surface by expansion of the monolayers resulted in an additional adsorption of peptides fr...
Source: Chembiochem - October 28, 2009 Category: Biochemistry Authors: Erbe A, Kerth A, Dathe M, Blume A Tags: Chembiochem Source Type: journals

Leveraging a Small-Molecule Modification to Enable the Photoactivation of Rho GTPases.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19877002 [PubMed - as supplied by publisher] (Source: Chembiochem)
Source: Chembiochem - October 28, 2009 Category: Biochemistry Authors: Harwood KR, Miller SC Tags: Chembiochem Source Type: journals

Effects of Fluorination on the Folding Kinetics of a Heterodimeric Coiled Coil.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19859931 [PubMed - as supplied by publisher] (Source: Chembiochem)
Source: Chembiochem - October 26, 2009 Category: Biochemistry Authors: Salwiczek M, Koksch B Tags: Chembiochem Source Type: journals

Inside Cover: Syringolin A Selectively Labels the 20 S Proteasome in Murine EL4 and Wild-Type and Bortezomib-Adapted Leukaemic Cell Lines (ChemBioChem 16/2009).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19856336 [PubMed - as supplied by publisher] (Source: Chembiochem)
Source: Chembiochem - October 23, 2009 Category: Biochemistry Authors: Clerc J, Florea BI, Kraus M, Groll M, Huber R, Bachmann AS, Dudler R, Driessen C, Overkleeft HS, Kaiser M Tags: Chembiochem Source Type: journals

Spotlights on our sister journals: ChemBioChem 16/2009.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Authors: PMID: 19856338 [PubMed - as supplied by publisher] (Source: Chembiochem)
Source: Chembiochem - October 23, 2009 Category: Biochemistry Tags: Chembiochem Source Type: journals

Preview: ChemBioChem 17/2009.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Authors: PMID: 19856345 [PubMed - as supplied by publisher] (Source: Chembiochem)
Source: Chembiochem - October 23, 2009 Category: Biochemistry Tags: Chembiochem Source Type: journals

Inhibition of HSP90 with Pochoximes: SAR and Structure-Based Insights.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The pochoximes, based on the radicicol pharmacophore, are potent inhibitors of heat shock protein 90 (HSP90) that retain their activity in vivo. Herein we report an extended library that broadly explores the structure-activity relationship (SAR) of the pochoximes with four points of diversity. Several modifications were identified that afford improved cellular efficacy, new opportunities for conjugation, and further diversifications. Cocrystal structures of pochoximes A and B with HSP90 show that pochoximes bind to a different conformation of HSP90 than radicicol and provide a rationale for the enhanced affinity of the...
Source: Chembiochem - October 23, 2009 Category: Biochemistry Authors: Barluenga S, Fontaine JG, Wang C, Aouadi K, Chen R, Beebe K, Neckers L, Winssinger N Tags: Chembiochem Source Type: journals

A Minimalist Substrate for Enzymatic Peptide and Protein Conjugation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Recently a number of nonnatural prenyl groups containing alkynes and azides have been developed as handles to perform click chemistry on proteins and peptides ending in the sequence "CAAX", where C is a cysteine that becomes alkylated, A is an aliphatic amino acid and X is any amino acid. When such molecules are modified, a tag containing a prenyl analogue and the "CAAX box" sequence remains. Here we report the synthesis of an alkyne-containing substrate comprised of only nine nonhydrogen atoms. This substrate was synthesized in six steps from 3-methylbut-2-en-1-ol and has been enzymatically incorporated into both prot...
Source: Chembiochem - October 23, 2009 Category: Biochemistry Authors: Wollack JW, Silverman JM, Petzold CJ, Mougous JD, Distefano MD Tags: Chembiochem Source Type: journals

Synthesis, Conjugation, and Immunological Evaluation of the Serogroup 6 Pneumococcal Oligosaccharides.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The first synthesis of the newly discovered oligosaccharide of pneumococcal serotype 6C and its spacer-containing analogue is reported. Conjugation of the spacer-containing oligosaccharides of pneumococcal saccharides 6A, 6B, 6C and derivatives thereof with bovine serum albumin (BSA) protein carrier was carried out by using squaric-acid approach to obtain the oligosaccharide-protein conjugates in excellent yields. The conjugates have been tested with a rabbit antiserum pool (Pool B) used for pneumococcal serotyping. The results showed that synthetic carbohydrate conjugates express epitopes found in native capsular poly...
Source: Chembiochem - October 23, 2009 Category: Biochemistry Authors: Parameswar AR, Park IH, Saksena R, Kováč P, Nahm MH, Demchenko AV Tags: Chembiochem Source Type: journals

Elucidating Protein Binding Mechanisms by Variable-c ITC.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19856370 [PubMed - as supplied by publisher] (Source: Chembiochem)
Source: Chembiochem - October 23, 2009 Category: Biochemistry Authors: Freiburger LA, Auclair K, Mittermaier AK Tags: Chembiochem Source Type: journals

Chivosazoles A and F, Cytostatic Macrolides from Myxobacteria, Interfere with Actin.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chivosazoles A and F, isolated from Sorangium cellulosum, showed high antiproliferative activity with different mammalian cell lines including human cancer cells. The chivosazoles caused a delay in G2/M phase of the cell cycle, and treated cells often contained two nuclei. By labeling F-actin it was shown that the actin cytoskeleton of the cells starts to break down after a few minutes of treatment. In vitro polymerization assays with purified G-actin revealed that the chivosazoles inhibit actin polymerization and also cause a depolymerization of pyrene-labeled F-actin microfilaments prepared in vitro. Chivosazoles are...
Source: Chembiochem - October 22, 2009 Category: Biochemistry Authors: Diestel R, Irschik H, Jansen R, Khalil MW, Reichenbach H, Sasse F Tags: Chembiochem Source Type: journals

Molecular Mechanism of the Hydration of Candida antarctica Lipase B in the Gas Phase: Water Adsorption Isotherms and Molecular Dynamics Simulations.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hydration is a major determinant of activity and selectivity of enzymes in organic solvents or in gas phase. The molecular mechanism of the hydration of Candida antarctica lipase B (CALB) and its dependence on the thermodynamic activity of water (a(w)) was studied by molecular dynamics simulations and compared to experimentally determined water sorption isotherms. Hydration occurred in two phases. At low water activity, single water molecules bound to specific water binding sites at the protein surface. As the water activity increased, water networks gradually developed. The number of protein-bound water molecules incr...
Source: Chembiochem - October 21, 2009 Category: Biochemistry Authors: Branco RJ, Graber M, Denis V, Pleiss J Tags: Chembiochem Source Type: journals

Increased Enantioselectivity by Engineering Bottleneck Mutants in an Esterase from Pseudomonas fluorescens.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Four hydrophobic and bulky amino acid residues (F126, F144, F159, and I225) were identified to form a bottleneck guarding the entrance to the active site of an esterase from Pseudomonas fluorescens (PFE I). Hence, a range of nonpolar amino acids were introduced into PFE I to broaden the substrate range and to increase enantioselectivity while preserving the hydrophobicity of the tunnel. First, single variants were created and then the most enantioselective ones were combined to find cooperative effects. This resulted in several mutants, which showed substantially enhanced enantioselectivity; for instance, in the kineti...
Source: Chembiochem - October 21, 2009 Category: Biochemistry Authors: Schließmann A, Hidalgo A, Berenguer J, Bornscheuer UT Tags: Chembiochem Source Type: journals

Designed RNAs with Two Peptide-Binding Units as Artificial Templates for Native Chemical Ligation of RNA-Binding Peptides.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we suppressed this effect by reducing the length of the original template derived from the Tetrahymena intron RNA. This modification, however, decreased the template ability for the specific reaction. As an alternative RNA that was as effective as the original template, we found that a self-dimerizing RNA was a promising template for peptide ligation without a nonspecific effect. PMID: 19834928 [PubMed - as supplied by publisher] (Source: Chembiochem)
Source: Chembiochem - October 14, 2009 Category: Biochemistry Authors: Kashiwagi N, Yamashita K, Furuta H, Ikawa Y Tags: Chembiochem Source Type: journals

Chaperone Activity of Bicyclic Nojirimycin Analogues for Gaucher Mutations in Comparison with N-(n-nonyl)Deoxynojirimycin.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gaucher disease (GD), the most prevalent lysosomal storage disorder, is caused by mutations of lysosomal beta-glucosidase (acid beta-Glu, beta-glucocerebrosidase); these mutations result in protein misfolding. Some inhibitors of this enzyme, such as the iminosugar glucomimetic N-(n-nonyl)-1-deoxynojirimycin (NN-DNJ), are known to bind to the active site and stabilize the proper folding for the catalytic form, acting as "chemical chaperones" that facilitate transport and maturation of acid beta-Glu. Recently, bicyclic nojirimycin (NJ) analogues with structure of sp(2) iminosugars were found to behave as very selective, ...
Source: Chembiochem - October 13, 2009 Category: Biochemistry Authors: Luan Z, Higaki K, Aguilar-Moncayo M, Ninomiya H, Ohno K, García-Moreno MI, Ortiz Mellet C, García Fernández JM, Suzuki Y Tags: Chembiochem Source Type: journals

The Global Virulence Regulators VsrAD and PhcA Control Secondary Metabolism in the Plant Pathogen Ralstonia solanacearum.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19830761 [PubMed - as supplied by publisher] (Source: Chembiochem)
Source: Chembiochem - October 13, 2009 Category: Biochemistry Authors: Schneider P, Jacobs JM, Neres J, Aldrich CC, Allen C, Nett M, Hoffmeister D Tags: Chembiochem Source Type: journals

Dynamic Sequence Modification: A Design Principle for Synthetic Informational Oligomers.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19830762 [PubMed - as supplied by publisher] (Source: Chembiochem)
Source: Chembiochem - October 13, 2009 Category: Biochemistry Authors: Diederichsen U Tags: Chembiochem Source Type: journals

A Fragment-Based Approach to Probing Adenosine Recognition Sites by Using Dynamic Combinatorial Chemistry.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A new strategy that combines the concepts of fragment-based drug design and dynamic combinatorial chemistry (DCC) for targeting adenosine recognition sites on enzymes is reported. We demonstrate the use of 5'-deoxy-5'-thioadenosine as a noncovalent anchor fragment in dynamic combinatorial libraries templated by Mycobacterium tuberculosis pantothenate synthetase. A benzyl disulfide derivative was identified upon library analysis by HPLC. Structural and binding studies of protein-ligand complexes by X-ray crystallography and isothermal titration calorimetry informed the subsequent optimisation of the DCC hit into a disul...
Source: Chembiochem - October 12, 2009 Category: Biochemistry Authors: Scott DE, Dawes GJ, Ando M, Abell C, Ciulli A Tags: Chembiochem Source Type: journals

Control of Lipase Enantioselectivity by Engineering the Substrate Binding Site and Access Channel.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lipase from Burkholderia cepacia (BCL) has proven to be a very useful biocatalyst for the resolution of 2-substituted racemic acid derivatives, which are important chiral building blocks. Our previous work showed that enantioselectivity of the wild-type BCL could be improved by chemical engineering of the substrate's molecular structure. From this earlier study, three amino acids (L17, V266 and L287) were proposed as targets for mutagenesis aimed at tailoring enzyme enantioselectivity. In the present work, a small library of 57 BCL single mutants targeted on these three residues was constructed and screened for enantio...
Source: Chembiochem - October 7, 2009 Category: Biochemistry Authors: Lafaquière V, Barbe S, Puech-Guenot S, Guieysse D, Cortés J, Monsan P, Siméon T, André I, Remaud-Siméon M Tags: Chembiochem Source Type: journals

The Role of Arginine 28 in Catalysis by Dihydrofolate Reductase from the Hyperthermophile Thermotoga maritima.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19816891 [PubMed - as supplied by publisher] (Source: Chembiochem)
Source: Chembiochem - October 7, 2009 Category: Biochemistry Authors: Loveridge EJ, Maglia G, Allemann RK Tags: Chembiochem Source Type: journals

Inside Cover: Cyclodextrin Aldehydes are Oxidase Mimics (ChemBioChem 15/2009).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19813201 [PubMed - as supplied by publisher] (Source: Chembiochem)
Source: Chembiochem - October 6, 2009 Category: Biochemistry Authors: Hauch Fenger T, Bjerre J, Bols M Tags: Chembiochem Source Type: journals

Characterization of the Rv3377c Gene Product, a Type-B Diterpene Cyclase, from the Mycobacterium tuberculosis H37 Genome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19813202 [PubMed - as supplied by publisher] (Source: Chembiochem)
Source: Chembiochem - October 6, 2009 Category: Biochemistry Authors: Nakano C, Hoshino T Tags: Chembiochem Source Type: journals

Spotlights on our sister journals: ChemBioChem 15/2009.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Authors: PMID: 19813204 [PubMed - as supplied by publisher] (Source: Chembiochem)
Source: Chembiochem - October 6, 2009 Category: Biochemistry Tags: Chembiochem Source Type: journals

Preview: ChemBioChem 16/2009.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Authors: PMID: 19813205 [PubMed - as supplied by publisher] (Source: Chembiochem)
Source: Chembiochem - October 6, 2009 Category: Biochemistry Tags: Chembiochem Source Type: journals

Dehydrocoelenterazine is the Organic Substance Constituting the Prosthetic Group of Pholasin.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19813233 [PubMed - as supplied by publisher] (Source: Chembiochem)
Source: Chembiochem - October 6, 2009 Category: Biochemistry Authors: Tanaka E, Kuse M, Nishikawa T Tags: Chembiochem Source Type: journals

C5-Functionalized LNA: Unparalleled Hybridization Properties and Enzymatic Stability.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19810078 [PubMed - as supplied by publisher] (Source: Chembiochem)
Source: Chembiochem - October 5, 2009 Category: Biochemistry Authors: Ostergaard ME, Kumar P, Baral B, Raible DJ, Santhosh Kumar T, Anderson BA, Guenther DC, Deobald L, Paszczynski AJ, Sharma PK, Hrdlicka PJ Tags: Chembiochem Source Type: journals

Discovery of a Small-Molecule Inhibitor of the KIX-KID Interaction.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19810079 [PubMed - as supplied by publisher] (Source: Chembiochem)
Source: Chembiochem - October 5, 2009 Category: Biochemistry Authors: Li BX, Xiao X Tags: Chembiochem Source Type: journals

Artificial Protein Block Copolymers Blocks Comprising Two Distinct Self-Assembling Domains.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19806626 [PubMed - as supplied by publisher] (Source: Chembiochem)
Source: Chembiochem - October 4, 2009 Category: Biochemistry Authors: Haghpanah JS, Yuvienco C, Civay DE, Barra H, Baker PJ, Khapli S, Voloshchuk N, Gunasekar SK, Muthukumar M, Montclare JK Tags: Chembiochem Source Type: journals

Amphiphilic Counterion Activators for DNA: Stimuli-Responsive Cation Transporters and Biosensors in Bulk and Lipid Bilayer Membranes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report that amphiphilic counterions can enable DNA to act as cation carrier, enzyme detector and biosensor. Calf thymus DNA is used as example throughout the study. Evaluation of a series of counterion activators suggests that strong amphiphilicity, alkyl or calix[4]arene tails and guanidinium cations give best results, whereas weak amphiphilicity, bola-amphiphilicity, planar aryl tails and ammonium cations are less satisfactory for various reasons. In the U-tube, DNA-counterion complexes can carry cations such as safranin O or p-xylene-bis-pyridinium bromide (DPX) across bulk chloroform membranes, whereas anions such a...
Source: Chembiochem - October 1, 2009 Category: Biochemistry Authors: Takeuchi T, Bagnacani V, Sansone F, Matile S Tags: Chembiochem Source Type: journals

A Cost-Effective Labeling Strategy for the NMR Study of Large Proteins: Selective (15)N-labeling of the Tryptophan Side Chains of Prolyl Oligopeptidase.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19798721 [PubMed - as supplied by publisher] (Source: Chembiochem)
Source: Chembiochem - September 30, 2009 Category: Biochemistry Authors: Tarragó T, Claasen B, Kichik N, Rodriguez-Mias RA, Gairí M, Giralt E Tags: Chembiochem Source Type: journals

Efficient Biooxidations Catalyzed by a New Generation of Self-Sufficient Baeyer-Villiger Monooxygenases.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19795432 [PubMed - as supplied by publisher] (Source: Chembiochem)
Source: Chembiochem - September 29, 2009 Category: Biochemistry Authors: Torres Pazmiño DE, Riebel A, de Lange J, Rudroff F, Mihovilovic MD, Fraaije MW Tags: Chembiochem Source Type: journals

Structures of Micelle-Bound Selected Insect Neuropeptides and Analogues: Implications for Receptor Selection.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Neuropeptides control essential physiological processes in insects such as water balance and muscle activity. Due to their metabolic instability and adverse physiochemical properties, insect neuropeptides are unsuited for a direct application in plant protection. As a first approximation towards the biologically active conformation, the structures of selected neuropeptides from economically important pest insects were determined by NMR spectroscopy and fluorescence measurements in a membrane-mimicking environment. A receptor binding model is suggested for the helicokinins and discussed in connection with biological act...
Source: Chembiochem - September 28, 2009 Category: Biochemistry Authors: Zdobinsky T, Scherkenbeck J, Zerbe O, Antonicek H, Chen H Tags: Chembiochem Source Type: journals

Structure and Replication of yDNA: A Novel Genetic Set Widened by Benzo-Homologation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In a functioning genetic system, the information-encoding molecule must form a regular self-complementary complex (for example, the base-paired double helix of DNA) and it must be able to encode information and pass it on to new generations. Here we study a benzo-widened DNA-like molecule (yDNA) as a candidate for an alternative genetic set, and we explicitly test these two structural and functional requirements. The solution structure of a 10 bp yDNA duplex is measured by using 2D-NMR methods for a simple sequence composed of T-yA/yA-T pairs. The data confirm an antiparallel, right-handed, hydrogen-bonded helix resemb...
Source: Chembiochem - September 23, 2009 Category: Biochemistry Authors: Lu H, Lynch SR, Lee AH, Kool ET Tags: Chembiochem Source Type: journals