Chemico-Biological InteractionsThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

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501 records returned

Tissue persistence of fumonisin B1 in ducks and after exposure to a diet containing the maximum European tolerance for fumonisins in avian feeds.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Toxicity and persistence of fumonisin B1 (FB1) in liver, kidney and muscle were investigated in ducks fed 5, 10 and 20mg FB1+FB2/kg feed during force-feeding. Mortality and signs of toxicity were only obtained with 20mg/kg, whereas an increased Sa/So ratio was observed from 5mg/kg on. Persistence of FB1 was only found in liver (16 and 20 microg FB1/kg liver in ducks fed 10 and 20 mg FB1+FB2/kg feed, respectively). Toxicokinetic studies were conducted by the intravenous route (IV, single dose: 10mg FB1/kg body weight) and the oral route (single dose: 100mg FB1/kg body weight), in growing ducks and in ducks during force-...
Source: Chemico-Biological Interactions - November 18, 2009 Category: Molecular Biology Authors: Tardieu D, Bailly JD, Benlashehr I, Auby A, Jouglar JY, Guerre P Tags: Chem Biol Interact Source Type: journals

Glucocorticoid and adrenalectomy effects on the rat aryl hydrocarbon receptor pathway depend on the dosing regimen and post-surgical time.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that mediates the effects of aromatic hydrocarbons, such as 2,3,7,8-tetrachlorodibenzo-p-dioxin and 3-methylcholanthrene (MC); the prototypical response is induction of drug-metabolizing enzymes. Factors that regulate AHR levels in vivo are poorly understood and it is also not clear how AHR levels affect aromatic hydrocarbon responsiveness. Our interest in pituitary-dependent regulation of AHR levels was prompted by two findings from our laboratory: (1) hypophysectomized rats have reduced hepatic levels of AHR protein; and (2) glucocorticoid...
Source: Chemico-Biological Interactions - November 18, 2009 Category: Molecular Biology Authors: Mullen Grey AK, Riddick DS Tags: Chem Biol Interact Source Type: journals

l-Arginine supplementation induces glutathione synthesis in interscapular brown adipose tissue through activation of glutamate-cysteine ligase expression: The role of nitric oxide.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined whether nitric oxide (NO) in vivo could induce interscapular brown adipose tissue (IBAT) glutathione synthesis. Data show that NO induces in vivo IBAT glutathione synthesis through activation of glutamate-cysteine ligase (GCL) mRNA and protein expression. This NO effect appeared to be mediated by nuclear factor-kappaB (NF-kappaB) activation. We have also observed a complex series of in vivo cellular responses during chronic inhibition of NO synthesis, suggesting that regulatory pathways unrelated to GCL alteration underlie glutathione level increase induced by N(omega)-nitro-l-arginine methyl ester (l-NAME). In...
Source: Chemico-Biological Interactions - November 18, 2009 Category: Molecular Biology Authors: Petrović V, Buzadzić B, Korać A, Vasilijević A, Janković A, Korać B Tags: Chem Biol Interact Source Type: journals

(-)-Epigallocatechin gallate prevents carbon tetrachloride-induced rat hepatic fibrosis by inhibiting the expression of the PDGFRbeta and IGF-1R.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hepatic fibrosis is a major complication of various chronic liver diseases. Activated hepatic stellate cells (HSCs) play a critical role in the development of liver fibrosis and the axis of platelet-derived growth factor (PDGF)/PDGF receptor (PDGFR), a member of receptor tyrosine kinases (RTKs), is closely associated with the activation of HSC. Insulin-like growth factor (IGF)-1 receptor (IGF-1R), which also belongs to RTKs, interacts with the PDGF/PDGFR axis, thereby cooperatively promoting hepatic fibrosis. We herein examined the effects of (-)-epigallocatechin gallate (EGCG), which inhibits the activation of several...
Source: Chemico-Biological Interactions - November 18, 2009 Category: Molecular Biology Authors: Yasuda Y, Shimizu M, Sakai H, Iwasa J, Kubota M, Adachi S, Osawa Y, Tsurumi H, Hara Y, Moriwaki H Tags: Chem Biol Interact Source Type: journals

Antioxidant activity and free radical scavenging reactions of hydroxybenzyl alcohols. Biochemical and pulse radiolysis studies.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Comparative studies on free radical scavenging by isomers of hydroxybenzyl alcohols (HBAs) were carried out to understand the molecular mechanisms involved in the antioxidant action. Using rat liver mitochondria as model systems, we have examined the radioprotective and antioxidant effects of hydroxybenzyl alcohols. Apart from their ability to scavenge free radicals and ferric reducing power, HBAs have shown good protection against radiation and oxidative stress. Using peroxyl radicals as initiator of reactive oxygen species (ROS), studies were carried out to evaluate antioxidant properties of HBAs against rat liver mi...
Source: Chemico-Biological Interactions - November 18, 2009 Category: Molecular Biology Authors: Dhiman SB, Kamat JP, Naik DB Tags: Chem Biol Interact Source Type: journals

Fetal arsenic exposure appears to facilitate endocrine disruption by postnatal diethylstilbestrol in neonatal mouse adrenal.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Fetal exposure of mice to arsenic and subsequent postnatal diethylstilbestrol (DES) facilitates production of urogenital system and liver tumors in the offspring when they reach adulthood. The adrenal is a target of endocrine disruption that could influence tumor formation at other sites. Thus, we examined possible fetal arsenic-induced adrenal effects as a potential basis of arsenic enhancement of DES carcinogenesis. Pregnant CD1 mice were given drinking water containing 85 ppm arsenic as sodium arsenite or unaltered water from day 8 to day 18 of gestation and were allowed to deliver normally. Groups of offspring were...
Source: Chemico-Biological Interactions - November 18, 2009 Category: Molecular Biology Authors: Liu J, Yu L, Coppin JF, Tokar EJ, Diwan BA, Waalkes MP Tags: Chem Biol Interact Source Type: journals

Novel nitro-oxy derivatives of celecoxib for the regulation of colon cancer cell growth.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Celecoxib is a non-steroidal anti-inflammatory drug (NSAID) developed as a selective inhibitor of cyclooxygenase-2 (COX-2). Despite the associated cardiovascular toxicity risk, celecoxib has been found to be effective in reducing cancer risk in animal and human studies. In the present study the antiproliferative activity of novel nitro-oxy-methyl substituted analogues of celecoxib (NO-cel), potentially less cardiotoxic, has been investigated in vitro on human colon cancer cells and compared with action of the parent drug. Moreover, experiments were performed in order to evaluate whether COX-2 pharmacological inhibition...
Source: Chemico-Biological Interactions - November 18, 2009 Category: Molecular Biology Authors: Bozzo F, Bassignana A, Lazzarato L, Boschi D, Gasco A, Bocca C, Miglietta A Tags: Chem Biol Interact Source Type: journals

Dual action of phenylarsine oxide on the glucose transport activity of GLUT1.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study investigated the effects of PAO on glucose uptake in L929 fibroblast cells, cells, which express only GLUT1. The data presented here reveal a dual effect of PAO. At low concentrations or short exposure times PAO stimulated glucose uptake reaching a peak activation of about 400% at 3 microM. At higher concentrations (40 microM), PAO clearly inhibited glucose uptake. At intermediate concentrations (10 microM), PAO had no effect under basal conditions but completely inhibited activation of glucose uptake by glucose deprivation and partially inhibited methylene blue-stimulated glucose uptake. PAO increased the speci...
Source: Chemico-Biological Interactions - November 18, 2009 Category: Molecular Biology Authors: Scott J, Opejin A, Tidball A, Stehouwer N, Rekman J, Louters LL Tags: Chem Biol Interact Source Type: journals

Chronic myelogenous leukemia and benzene exposure: a systematic review and meta-analysis of the case-control literature.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Benzene exposure is well demonstrated as a cause of acute myelogenous leukemia, but not of chronic myelogenous leukemia. Previous literature reviews based on case series and cohort studies have not shown an association. We have now conducted a literature search for case-control studies that examine the association between benzene exposure and chronic myelogenous leukemia. Six case-control studies have been found. These derive from occupational groups, cancer registries, and a clinical laboratory. Their exposure ascertainments are all based on job histories, job-exposure matricies, or industrial hygiene data. The odds r...
Source: Chemico-Biological Interactions - November 18, 2009 Category: Molecular Biology Authors: Lamm SH, Engel A, Joshi KP, Byrd DM, Chen R Tags: Chem Biol Interact Source Type: journals

Modulatory role of lipoic acid on lipopolysaccharide-induced oxidative stress in adult rat Sertoli cells in vitro.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Inflammatory reactions to microbial infections may cause male infertility. The mechanisms of inhibition of spermatogenesis can be studied in vitro using rat Sertoli cells. Bacterial lipopolysaccharides (LPS) induce acute inflammations. So LPS treated Sertoli cells can be used to test for new therapeutic compounds. The present study aimed to investigate the protective efficacy of dl-alpha-lipoic acid (LA) on lipopolysaccharide (LPS)-induced oxidative stress in adult rat Sertoli cells. Sertoli cells were divided into 4 groups. Group I served as a control incubated with water (vehicle). Groups II and IV were incubated wit...
Source: Chemico-Biological Interactions - November 18, 2009 Category: Molecular Biology Authors: Aly HA, Lightfoot DA, El-Shemy HA Tags: Chem Biol Interact Source Type: journals

Superoxide anion mediated mitochondrial dysfunction leads to hepatocyte apoptosis preferentially in the periportal region during copper toxicity in rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chronic exposure to copper induces hepatocellular apoptosis with greater injury in the periportal region compared to the perivenous region. Here we have identified the factors responsible for the development of regional damage in the liver under in vivo conditions. Enhanced production of reactive oxygen species (ROS) with predominance of superoxide radical (O(2)(-)) indicates the contribution of redox imbalance in the process. This may be linked with copper catalyzed oxidation of GSH to GSSG resulting in the generation of O(2)(-). Downregulation of Cu-Zn SOD in consequence of the degradation of this enzyme, causes decr...
Source: Chemico-Biological Interactions - November 18, 2009 Category: Molecular Biology Authors: Roy DN, Mandal S, Sen G, Biswas T Tags: Chem Biol Interact Source Type: journals

Oxaliplatin-induced gamma-H2AX activation via both p53-dependent and -independent pathways but is not associated with cell cycle arrest in human colorectal cancer cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we investigated the roles of p53 and gamma-H2AX following oxaliplatin treatment, as they are important effector proteins for apoptosis and DSB repair, respectively. Both phosphorylated-p53 (Ser-15) and gamma-H2AX were up-regulated and accumulated in the nuclei of p53-wild type human colorectal cancer HCT116 cells after exposure to oxaliplatin. Concomitantly, oxaliplatin-induced G2/M arrest was associated with a reduction in both cyclin B1 expression and phosphorylated-CDC2 (Thr-161). Release of G2/M arrest by caffeine was accompanied by a decrease in the levels of p53/p21; however, gamma-H2AX levels were unc...
Source: Chemico-Biological Interactions - November 18, 2009 Category: Molecular Biology Authors: Chiu SJ, Lee YJ, Hsu TS, Chen WS Tags: Chem Biol Interact Source Type: journals

Synergistic increases of metabolism and oxidation-reduction genes on their expression after combined treatment with a CYP1A inducer and andrographolide.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We previously reported that andrographolide greatly enhanced the expression of CYP1A1. Since andrographolide is a major constituent of Andrographis paniculata, which has been employed for centuries in Asia and Europe as a folk remedy, we further analyzed genes whose expression was modified by andrographolide using primary-cultured mouse hepatocytes in a microarray assay. With the threshold for modification set at 2-fold, andrographolide up-regulated 18 genes among 28,853 genes, most of them related to metabolism/oxidation/reduction. Meanwhile, 5 genes, related to protein binding or calcium ion binding, were down-regula...
Source: Chemico-Biological Interactions - November 18, 2009 Category: Molecular Biology Authors: Chatuphonprasert W, Jarukamjorn K, Kondo S, Nemoto N Tags: Chem Biol Interact Source Type: journals

Inhibition of proliferation of a hepatoma cell line by fucoxanthin in relation to cell cycle arrest and enhanced gap junctional intercellular communication.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we hypothesized that fucoxanthin may cause cell cycle arrest and enhance gap junctional intercellular communication (GJIC) in SK-Hep-1 human hepatoma cells. Data revealed that fucoxanthin (1-20microM) strongly and concentration-dependently inhibited the proliferation of SK-Hep-1 cells at 24h of incubation, whereas fucoxanthin facilitated the growth of a murine embryonic hepatic (BNL CL.2) cells at 24h of incubation and only slightly slowed the cell proliferation at 48h. In SK-Hep-1 cells, fucoxanthin caused cell cycle arrest at G0/G1 phase and induced cell apoptosis, as evidenced by increased subG1 cells and...
Source: Chemico-Biological Interactions - November 18, 2009 Category: Molecular Biology Authors: Liu CL, Huang YS, Hosokawa M, Miyashita K, Hu ML Tags: Chem Biol Interact Source Type: journals

Altered pH homeostasis modulates the glutathione peroxidase mimics and other antioxidant properties of diphenyl diselenide.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Recent evidences have shown that the in vivo antioxidant chemistry of organoselenium compounds such as diphenyl diselenide (DPDS) is complex and it is not completely understood. The complexity is partly due to the fact that DPDS is generally thought to exert its antioxidant action by mimicking glutathione peroxidase (GPx) with concomitant utilization of glutathione (GSH) in vitro. In contrast to in vitro data, we recently observed that DPDS increases rather than diminish GSH levels in diabetic models. The present study therefore sought to investigate a possible change in the antioxidant mechanisms of DPDS in changing p...
Source: Chemico-Biological Interactions - November 18, 2009 Category: Molecular Biology Authors: Ogunmoyole T, Rocha JB, Okoronkwo AE, Kade IJ Tags: Chem Biol Interact Source Type: journals

Mechanism of action of novel naphthofuranquinones on rat liver microsomal peroxidation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In order to elucidate the effect on mammal systems of new derivatives from 2-hydroxy-3-allyl-naphthoquinone, alpha-iodinated naphthofuranquinone (NPPN-3223), beta-iodinated naphthofuranquinone (NPPN-3222) and beta-methyl naphthofuranquinone (NPPN-3226) synthesized as possible trypanocidal agents, their effect on rat liver microsomal lipid peroxidation was investigated. They (a) inhibited NADPH-dependent, iron-catalyzed microsomal rat liver lipid peroxidation; (b) did not inhibit the tert-butyl hydroperoxide-dependent lipid peroxidation; (c) did not inhibit ascorbate-lipid peroxidation with the exception of NPPN-3226 wh...
Source: Chemico-Biological Interactions - November 18, 2009 Category: Molecular Biology Authors: Elingold I, Taboas MI, Casanova MB, Galleano M, Silva RS, Menna-Barreto RF, Ventura Pinto A, de Castro SL, Costa LE, Dubin M Tags: Chem Biol Interact Source Type: journals

Cytotoxic, cytoprotective and antioxidant activities of resveratrol and analogues in C6 astroglioma cells in vitro.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Resveratrol (3,4',5-trans-trihydroxystilbene) and other hydroxystilbenes exhibit in vitro antioxidant as well as prooxidant effects. The antioxidant properties are assumed to enable these compounds to protect cells from oxidative damage. The prooxidant effects are held likely to be responsible for their cytotoxic, anti-proliferative or pro-apoptotic effects observed in vitro. Regarding antioxidant/prooxidant activities in the past various studies were performed aiming at defining structure-activity relationships for hydroxystilbenes using cell-free systems. In the present study cultured C6 glioma cells were used in ord...
Source: Chemico-Biological Interactions - November 18, 2009 Category: Molecular Biology Authors: Rüweler M, Gülden M, Maser E, Murias M, Seibert H Tags: Chem Biol Interact Source Type: journals

Non-dioxin-like-PCBs phosphorylate Mdm2 at Ser166 and attenuate the p53 response in HepG2 cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study we investigated the effects of 20 NDL-PCBs (concentration range 0.01-10microM) on pMdm2 Ser166, pErk Tyr204 and p53 on HepG2 cells. Six of the NDL-PCBs induced pErk Tyr204 and pMdm3 Ser166. This effect correlated with lowered basal levels of p53, as well as with an attenuated p53 response induced by etoposide and leptomycin B. Similar effects were induced by TCDD and the DL-PCB 126. We conclude that both DL-PCBs and NDL-PCBs in low concentrations can induce alterations in p53 signaling and that these effects can be correlated to rat liver carcinogenesis. PMID: 19751709 [PubMed - indexed for MEDLINE] (Sour...
Source: Chemico-Biological Interactions - November 18, 2009 Category: Molecular Biology Authors: Al-Anati L, Högberg J, Stenius U Tags: Chem Biol Interact Source Type: journals

Herb-drug interaction of silymarin or silibinin on the pharmacokinetics of trazodone in rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the present study finds no marked effects of silymarin and silibinin on the pharmacokinetics of trazodone under normal daily doses and the relative safety of taking the herb with trazodone. PMID: 19765569 [PubMed - indexed for MEDLINE] (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - November 18, 2009 Category: Molecular Biology Authors: Chang JC, Wu YT, Lee WC, Lin LC, Tsai TH Tags: Chem Biol Interact Source Type: journals

Hyper- and hypo-induction of cytochrome P450 activities with Aroclor 1254 and 3-methylcholanthrene in Cyp1a2(-/-) mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The response of hepatic mono-oxygenase activities to Aroclor 1254 or 3-methylcholanthrene was investigated in wild-type and Cyp1a2(-/-) mice. Cytochrome P450 concentrations were similar in naïve Cyp1a2(-/-) and wild-type mice. There was no difference between naïve wild-type and Cyp1a2(-/-) animals in 7-ethoxyresorufin and 7-ethoxy-4-trifluoromethylcoumarin dealkylase activities, nor was the induction response after 3-methylcholanthrene any different between the two genotypes. However, both activities were induced to a higher extent in Cyp1a2(-/-) mice after Aroclor 1254. In contrast, 7-pentoxyresorufin dealky...
Source: Chemico-Biological Interactions - November 18, 2009 Category: Molecular Biology Authors: Barker ML, Hathaway LB, Arch DD, Westbroek ML, Kushner JP, Phillips JD, Franklin MR Tags: Chem Biol Interact Source Type: journals

Effect of permethrin insecticide on rat polymorphonuclear neutrophils.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, immunotoxicity of permethrin measured in rats could prompt future studies on the consequences of chronic insecticide exposure. PMID: 19772857 [PubMed - indexed for MEDLINE] (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - November 18, 2009 Category: Molecular Biology Authors: Gabbianelli R, Falcioni ML, Nasuti C, Cantalamessa F, Imada I, Inoue M Tags: Chem Biol Interact Source Type: journals

Effect of alpha tocopherol acetate in Walker 256/B cells-induced oxidative damage in a rat model of breast cancer skeletal metastases.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The pathophysiological changes and the oxidative-antioxidative status were evaluated in the bone microenvironment of rat inoculated with Walker 256/B mammary gland carcinoma cells, and used alpha-tocopherol acetate (ATA) as a countermeasure. Walker 256/B cells were injected into the right femora of aged male rats. Animals were randomized into three groups: 12 rats were injected with saline (control group); 14 rats were injected with Walker 256/B cells (5x10(4)) in the medullar cavity (W256 group); 14 rats were inoculated with Walker 256/B cells and treated with ATA (45mg/kg BW) (W256+ATA group). After 20 days, rats wer...
Source: Chemico-Biological Interactions - November 18, 2009 Category: Molecular Biology Authors: Badraoui R, Blouin S, Moreau MF, Gallois Y, Rebai T, Sahnoun Z, Baslé M, Chappard D Tags: Chem Biol Interact Source Type: journals

Expression of hepatic antioxidant genes in L-thyroxine-induced hyperthyroid rats: Regulation by vitamin E and curcumin.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Earlier we have demonstrated that oral supplementation of vitamin E and curcumin alleviates hyperthyroidism-induced oxidative stress and distorted histoarchitecture in rat liver (Chem. Biol. Interact. 173:105-114, 2008). To delineate the underlying mechanism of protection, the present study was undertaken to investigate the regulatory role of vitamin E and curcumin on antioxidant gene (AOG) expression in hyperthyroid rat liver. Adult male rats were rendered hyperthyroid by administration of 0.0012% L-thyroxine in their drinking water, while vitamin E (200mg/Kg body weight) and curcumin (30mg/Kg body weight) were supple...
Source: Chemico-Biological Interactions - November 12, 2009 Category: Molecular Biology Authors: Subudhi U, Chainy GB Tags: Chem Biol Interact Source Type: journals

How much does benzene contribute to the overall burden of cancer due to occupation?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19914225 [PubMed - as supplied by publisher] (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - November 12, 2009 Category: Molecular Biology Authors: Rushton L, Brown TP, Cherrie J, Fortunato L, Van Tongeren M, Hutchings SJ Tags: Chem Biol Interact Source Type: journals

Dietary flavonoids suppress azoxymethane-induced colonic preneoplastic lesions in male C57BL/KsJ-db/db mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Obesity is known to be a risk factor for colon carcinogenesis. Although there are several reports on the chemopreventive abilities of dietary flavonoids in chemically induced colon carcinogenesis, those have not been addressed in an obesity-associated carcinogenesis model. In the present study, the effects of 3 flavonoids (chrysin, quercetin and nobiletin) on modulation of the occurrence of putative preneoplastic lesions, aberrant crypt foci (ACF), and beta-catenin accumulated crypts (BCACs) in the development of colon cancer were determined in male db/db mice with obesity and diabetic phenotypes. Male db/db mice were ...
Source: Chemico-Biological Interactions - November 12, 2009 Category: Molecular Biology Authors: Miyamoto S, Yasui Y, Ohigashi H, Tanaka T, Murakami A Tags: Chem Biol Interact Source Type: journals

Ensuring comparability of benzene exposure estimates across three nested case-control studies in the petroleum industry in support of a pooled epidemiological analysis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The revised exposure estimates will be used in the pooled analysis to examine the risk of haematopoietic cancers and benzene exposure. This exercise provided an important quality control check on the exposure estimates and identified similarly exposed Job Categories that could be grouped for risk assessment analyses. PMID: 19914227 [PubMed - as supplied by publisher] (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - November 12, 2009 Category: Molecular Biology Authors: Glass DC, Armstrong TW, Pearlman ED, Verma DK, Schnatter AR, Rushton L Tags: Chem Biol Interact Source Type: journals

Benzene-Initiated Oxidative Stress: Effects on Embryonic Signaling Pathways.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Approximately 90% of childhood cancers are of unknown etiology; however, it is hypothesized that in utero carcinogen exposure may contribute. Epidemiological studies have correlated parental exposure to benzene with an increased incidence of childhood leukemias. However, mechanisms of benzene-induced carcinogenesis following in utero exposure remain unknown. We hypothesize that in utero exposure to benzene causes alterations in the redox sensitive signaling pathways involving c-Myb, Pim-1, AKT, ERK-MAPK, p38-MAPK, and NF-kappaB via the production of reactive oxygen species (ROS) as a possible mechanism of in utero init...
Source: Chemico-Biological Interactions - November 11, 2009 Category: Molecular Biology Authors: Badham HJ, Renaud SJ, Wan J, Winn L Tags: Chem Biol Interact Source Type: journals

Apoptosis Induction in Human Leukemic Cells by a Novel Protein Bengalin, Isolated from Indian Black Scorpion Venom: through Mitochondrial Pathway and Inhibition of Heat Shock Proteins.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Scorpion venom possesses protein toxins having numerous biological activities, some of which are potentially anticancerous. Previously we had reported antiproliferative activity of the venom of Indian black scorpion, Heterometrus bengalensis Koch. Here we have isolated and purified a novel protein named Bengalin (72kD) from the venom, responsible for antiproliferative and apoptogenic activities against human leukemic cells U937 (histiocytic lymphoma) and K562 (chronic myelogenous leukemia). N-terminal sequence of first 20 amino acids of Bengalin was G-P-L-T-I-L-H-I-N-D-V-H-A-A/R-F-E-Q/G-F/G-N-T. Bengalin induced cell g...
Source: Chemico-Biological Interactions - November 11, 2009 Category: Molecular Biology Authors: Gupta SD, Gomes A, Debnath A, Saha A, Gomes A Tags: Chem Biol Interact Source Type: journals

A possible correlation between the correction of endothelial dysfunction and normalization of high blood pressure levels by 1, 3, 4-oxadiazole derivative, an L-type Ca(2+) channel blocker in deoxycorticosterone acetate and N(G)-nitro L-arginine hypertensive rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We have previously demonstrated the vasorelaxant activity of 1, 3, 4 oxadiazole derivative (NOX-1) through L-type Ca(2+) channel blockage. In the present study, we investigated whether the correction of endothelial dysfunction can be dependent of the normalization of high blood pressure levels by 1, 3, 4-oxadiazole derivative (NOX-1) in deoxycorticosterone acetate (DOCA-salt) and N(G)-nitro-L-arginine (L-NNA) hypertensive rats. In DOCA-salt and L-NNA hypertensive rats the mean systolic blood pressure (MSBB) was 185.3+/-4.7 and 170.2+/-4.1 mmHg, whereas after administration of NOX-1 to hypertensive rats, MSBB was 127.8+...
Source: Chemico-Biological Interactions - November 10, 2009 Category: Molecular Biology Authors: Bankar GR, Nampurath GK, Nayak PG, Bhattacharya S Tags: Chem Biol Interact Source Type: journals

Interaction of porphyrins with human organic anion transporting polypeptide 1B1.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The existence of a porphyrin uptake transporter in hepatocytes has been hypothesized in recent years, but to date it has not been identified. While the linear tetrapyrrole bilirubin has been shown to be a substrate for the organic anion transporting polypeptide 1B1 (OATP1B1), similar studies have not been conducted for the cyclic tetrapyrroles (porphyrins). The aim of this study was to determine the structural features of linear and cyclic tetrapyroles necessary for interaction with OATP1B1. The interaction was quantified using HEK cells stably expressing OATP1B1 and measuring the inhibition of OATP1B1-mediated uptake ...
Source: Chemico-Biological Interactions - October 30, 2009 Category: Molecular Biology Authors: Campbell SD, Lau WF, Xu JJ Tags: Chem Biol Interact Source Type: journals

Towards the mechanism and comparative effect of diphenyl diselenide, diphenyl ditelluride and ebselen under various pathophysiological conditions in rat's kidney preparation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study provides evidence for acidosis catalyzed oxidative stress in kidney homogenate and for the first time anti-oxidant potential of diphenyl diselenide and diphenyl ditelluride not only at physiological pH but also at a range of acidic values. PMID: 19589335 [PubMed - indexed for MEDLINE] (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - October 30, 2009 Category: Molecular Biology Authors: Hassan W, Ibrahim M, Rocha JB Tags: Chem Biol Interact Source Type: journals

Alteration of Toll-like receptor 4 activation by 4-hydroxy-2-nonenal mediated by the suppression of receptor homodimerization.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Toll-like receptors (TLRs) detect invading microbial pathogens and initiate immune responses as part of host defense mechanisms. They also respond to host-derived substances released from injured cells and tissues to ensure wound healing and tissue homeostasis. Dysregulation of TLRs increases the risk of chronic inflammatory diseases and immune disorders. Inflammatory events are often accompanied by oxidative stress, which generates lipid peroxidation products such as 4-hydroxy-2-nonenal (4-HNE). Therefore, we investigated if 4-HNE affects TLR activation. We found that 4-HNE blocked LPS (a TLR4 agonist)-induced activat...
Source: Chemico-Biological Interactions - October 30, 2009 Category: Molecular Biology Authors: Kim YS, Park ZY, Kim SY, Jeong E, Lee JY Tags: Chem Biol Interact Source Type: journals

Apigenin-induced apoptosis is mediated by reactive oxygen species and activation of ERK1/2 in rheumatoid fibroblast-like synoviocytes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we investigated the roles of apigenin in RA-FLSs. The survival rate decreased, and apoptotic cell death was induced by apigenin treatment in RA-FLSs. Apigenin treatment resulted in activation of the mitogen-activated protein kinase (MAPK) ERK1/2, and pretreatment with an ERK inhibitor PD98059 dramatically reduced apigenin-induced apoptosis. We found that apigenin-mediated production of a large amount of intracellular reactive oxygen species (ROS) caused activation of ERK1/2 and apoptosis; treatment with the antioxidant Tiron strongly inhibited the apigenin-induced generation of ROS, phosphorylation of ERK1/2...
Source: Chemico-Biological Interactions - October 30, 2009 Category: Molecular Biology Authors: Shin GC, Kim C, Lee JM, Cho WS, Lee SG, Jeong M, Cho J, Lee K Tags: Chem Biol Interact Source Type: journals

Responses of PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) in MCF-7 cells are culture condition dependent.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the effects of PhIP and estradiol in MCF-7 cells are dependent on culture conditions. The detected PhIP-induced changes are weaker compared to those induced by estradiol. PMID: 19647730 [PubMed - indexed for MEDLINE] (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - October 30, 2009 Category: Molecular Biology Authors: Immonen E, Serpi R, Vähäkangas K, Myllynen P Tags: Chem Biol Interact Source Type: journals

Crystalline silica Min-U-Sil 5 induces oxidative stress in human bronchial epithelial cells BEAS-2B by reducing the efficiency of antiglycation and antioxidant enzymatic defenses.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study we investigated the hypothesis that crystalline silica Min-U-Sil 5 can induce elevations in intracellular ROS in human bronchial epithelial cells BEAS-2B, via an indirect mechanism that involves ROS-inducing intracellular factors, through a reduction of antiglycation (glyoxalase enzymes) and antioxidant (paraoxonase 1 and glutathione-S-transferases) enzymatic defenses. The results show that crystalline silica Min-U-Sil 5 causes a significant reduction in the efficiency of antiglycation and antioxidant enzymatic defenses, paralleled by an early and extensive ROS generation, thus preventing the cells from an ef...
Source: Chemico-Biological Interactions - October 30, 2009 Category: Molecular Biology Authors: Antognelli C, Gambelunghe A, Del Buono C, Murgia N, Talesa VN, Muzi G Tags: Chem Biol Interact Source Type: journals

A novel phenotype-based approach for systematically screening antiproliferation metallodrugs.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, zebrafish were employed as a whole-organism model to screen new Ru compounds for anti-cell proliferation activity. After soaking fish embryos in cisplatin and five Ru derivatives, [Ru(terpy)(bpy)Cl]Cl, [Ru(terpy)(dppz)OH(2)](ClO(4))(2), [Ru(terpy)(tMen)OH(2)](ClO(4))(2), [Ru(terpy)(Me(4)Phen)OH(2)](ClO(4))(2), and Ru(bpy)(2)Cl(2), only cisplatin and [Ru(terpy)(bpy)Cl]Cl-treated embryos displayed obvious phenotypic effects, such as fin-reduction. After further modification of [Ru(terpy)(bpy)Cl]Cl's main structure and the synthesis of two structurally related compounds, [Ru(terpy)(dcbpyH(2))Cl]Cl and [Ru(terpy...
Source: Chemico-Biological Interactions - October 30, 2009 Category: Molecular Biology Authors: Wang YH, Cheng CC, Lee WJ, Chiou ML, Pai CW, Wen CC, Chen WL, Chen YH Tags: Chem Biol Interact Source Type: journals

Antidiabetic and antilipidemic effect of eremanthin from Costus speciosus (Koen.)Sm., in STZ-induced diabetic rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The increasing prevalence of diabetes mellitus worldwide is an issue of major socio-economic concern. Diabetes mellitus is a complex and a multifarious group of disorders that disturbs the metabolism of carbohydrates, fat and protein. Medicinal plants play an important role in the management of diabetes mellitus especially in developing countries. Costus speciosus is widely used in Indian medicine to treat various diseases. Eremanthin was isolated from C. speciosus. The structure was identified using gas chromatography-mass spectrometry (GC-MS) analysis. Eremanthin was administered to streptozotocin (STZ) (50mg/kg bw) ...
Source: Chemico-Biological Interactions - October 30, 2009 Category: Molecular Biology Authors: Eliza J, Daisy P, Ignacimuthu S, Duraipandiyan V Tags: Chem Biol Interact Source Type: journals

Induced expression of drug metabolizing enzymes by preventive agents: role of the antioxidant response element.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Identifying agents that block tumor initiation is a goal of cancer prevention. The ability of a chemically varied group of agents to induce various drug metabolizing genes in livers of rats was examined. Sprague-Dawley rats were treated for 7 days with various agents in the diet or by gavage. The agents examined, which might be expected to respond via specific nuclear receptors (CAR, AhR) as well as antioxidant response elements (AREs), included Phase I/II inducers [5,6-benzoflavone (BF, 5000mg/kg diet), diallyl sulfide (DAS, 500mg/kg BW/day), ethoxyquin (EXO, 300mg/kg BW/day) and phenobarbital (PB, 500mg/kg diet)] or ...
Source: Chemico-Biological Interactions - October 30, 2009 Category: Molecular Biology Authors: Lubet RA, Yao R, Grubbs CJ, You M, Wang Y Tags: Chem Biol Interact Source Type: journals

Modulation of arsenic trioxide-induced apoptosis by genistein and functionally related agents in U937 human leukaemia cells. Regulation by ROS and mitogen-activated protein kinases.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The proved radio- and chemo-sensitizing capacity of genistein supports the potential use of this isoflavone in antitumour therapies. In this regard, we recently reported that genistein potentiates apoptosis induction by the anti-leukaemic agent arsenic trioxide (ATO) via reactive oxygen species (ROS) generation and p38-MAPK activation. In the present study we analyze the action of agents sharing functional similarities with the isoflavone, namely 17-beta-estradiol, the DNA topoisomerase II poison etoposide, and the tyrosine kinase (PTK) inhibitors herbimycin A, epigallocatechin-3-gallate (EGCG) and adaphostin, in U937 ...
Source: Chemico-Biological Interactions - October 30, 2009 Category: Molecular Biology Authors: Sánchez Y, Calle C, de Blas E, Aller P Tags: Chem Biol Interact Source Type: journals

Effect of acute and chronic administration of progesterone, estrogen, FSH and LH on oxidant and antioxidant parameters in rat gastric tissue.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study was conducted to investigate whether gastro-protective and gastro-toxic effects of acute and chronic administration of progesterone, estrogen, FSH and LH were related to oxidant and antioxidant parameters. Chronic administration of progesterone at a low dose (1mg/kg), which probably could not stimulate progesterone receptors (PRs), inhibited oxidative stress of FSH in gastric tissue by suppressing FSH. Progesterone (5mg/kg) may have been caused oxidative stress as reflected by PR stimulation. FSH may have decreased antioxidant parameters and increased oxidant parameters via PRs. Chronic administration of low dos...
Source: Chemico-Biological Interactions - October 30, 2009 Category: Molecular Biology Authors: Kumtepe Y, Borekci B, Karaca M, Salman S, Alp HH, Suleyman H Tags: Chem Biol Interact Source Type: journals

The World Health Organization (WHO) Classification of Tumors of the Hematopoietic and Lymphoid Tissues: An overview with emphasis on the myeloid neoplasms.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The World Health Organization (WHO) classification of myeloid and lymphoid neoplasms utilizes morphology, immunophenotype, genetics and clinical features to define disease entities of clinical significance. It is a consensus classification in which a number of experts have agreed on the classification and diagnostic criteria. In general, the classification stratifies neoplasms according to their lineage (myeloid, lymphoid, histiocytic/dendritic) and distinguishes neoplasms of precursor cells from those comprised of functionally mature cells. Lymphoid neoplasms are derived from cells that frequently have features that r...
Source: Chemico-Biological Interactions - October 23, 2009 Category: Molecular Biology Authors: Vardiman JW Tags: Chem Biol Interact Source Type: journals

Comparative study of the oxidation of propranolol enantiomers in hepatic and small intestinal microsomes from cynomolgus and marmoset monkeys.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Oxidative metabolism of propranolol (PL) enantiomers (R-PL and S-PL) to 4-hydroxypropranolol (4-OH-PL), 5-OH-PL and N-desisopropylpropranolol (NDP) was examined in hepatic microsomes from cynomolgus and marmoset monkeys and in small intestinal microsomes from monkeys and humans. In hepatic microsomes, levels of oxidation activities were similar between the two monkey species, and substrate enantioselectivity (R-PL<S-PL) was observed in the formation of 5-OH-PL and/or NDP. Kinetic experiments revealed that the formation of all metabolites was biphasic in cynomolgus monkeys, whereas only the formation of NDP was bipha...
Source: Chemico-Biological Interactions - October 21, 2009 Category: Molecular Biology Authors: Shimizudani T, Nagaoka K, Hanioka N, Yamano S, Narimatsu S Tags: Chem Biol Interact Source Type: journals

Local anesthetics structure-dependently interact with anionic phospholipid membranes to modify the fluidity.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
While bupivacaine is more cardiotoxic than other local anesthetics, the mechanistic background for different toxic effects remains unclear. Several cardiotoxic compounds act on lipid bilayers to change the physicochemical properties of membranes. We comparatively studied the interaction of local anesthetics with lipid membranous systems which might be related to their structure-selective cardiotoxicity. Amide local anesthetics (10-300muM) were reacted with unilamellar vesicles which were prepared with different phospholipids and cholesterol of varying lipid compositions. They were compared on the potencies to modify me...
Source: Chemico-Biological Interactions - October 21, 2009 Category: Molecular Biology Authors: Tsuchiya H, Ueno T, Mizogami M, Takakura K Tags: Chem Biol Interact Source Type: journals

Protective effect of Anacardic Acids from Cashew (Anacardium occidentale) on ethanol-induced gastric damage in mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cashew nut-shell liquid and the contained anacardic acids (AAs) have been shown to possess antioxidnt, lipoxygenase inhibitory, anti-Helicobacter pylori and antitumor properties. Despite these known effects, hitherto there were no published reports on their likely gastroprotective effects. The present study was designed to verify whether AAs afford gastroprotection against the ethanol-induced gastric damage and to examine the underlying mechanism(s). Gastric damage was induced by intragastric administration of 0.2mL of ethanol (96%). Mice in groups were pretreated orally with AAs (10, 30 and 100mg/kg), misoprostol (50m...
Source: Chemico-Biological Interactions - October 21, 2009 Category: Molecular Biology Authors: Morais TC, Pinto NB, Carvalho KM, Rios JB, Ricardo NM, Trevisan MT, Rao VS, Santos FA Tags: Chem Biol Interact Source Type: journals

Co-treating with arecoline and 4-nitroquinoline 1-oxide to establish a mouse model mimicking oral tumorigenesis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, we have established a powerful animal model that enables the study of the promoting effects of arecoline on tongue tumorigenesis. Data subsequently attained from this mouse model support a role for alphaB-crystallin and Hsp27 as clinical markers for tumor progression. PMID: 19840781 [PubMed - as supplied by publisher] (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - October 15, 2009 Category: Molecular Biology Authors: Chang NW, Pei RJ, Tseng HC, Yeh KT, Chan HC, Lee MR, Lin C, Hsieh WT, Kao MC, Tsai MH, Lin CF Tags: Chem Biol Interact Source Type: journals

Pharmacokinetic and Tissue Distribution Study of [14C]fluasterone in Male Beagle Dogs Following Intravenous, Oral and Subcutaneous Dosing Routes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the sc route of administration offers some advantages to po and iv due to the prolonged release and increased retention through 24hours. PMID: 19836365 [PubMed - as supplied by publisher] (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - October 13, 2009 Category: Molecular Biology Authors: Lindeblad MO, Bauer KS, Zakharov AD, Hill JM, Green JS, Thomas BF, Schwartz A, Kapetanovic IM, Lyubimov A Tags: Chem Biol Interact Source Type: journals

Sesamin attenuates behavioral, biochemical and histological alterations induced by reversible middle cerebral artery occlusion in the rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Restoration of blood flow to an ischemic brain region is associated with generation of reactive oxygen species (ROS) with consequent reperfusion injury. ROS cause lipid peroxidation, protein oxidation, and DNA damage, all of which are deleterious to cells. So diminishing the production of free radicals and scavenging them may be a successful therapeutic strategy for the protection of brain tissue in cerebral stroke. The present study investigated the neuroprotective effect of sesamin (Sn) to reduce brain injury after middle cerebral artery occlusion (MCAO). The middle cerebral artery (MCA) of adult male Wistar rat was ...
Source: Chemico-Biological Interactions - October 12, 2009 Category: Molecular Biology Authors: Khan MM, Ishrat T, Ahmad A, Hoda MN, Khan MB, Khuwaja G, Srivastava P, Raza SS, Islam F Tags: Chem Biol Interact Source Type: journals

MicroRNAs and copy number changes: New levels of gene regulation in acute myeloid leukemia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Alkylating agents, topoisomerase II inhibitors, ionizing radiation, and other hematotoxins induce DNA damage in hematopoietic stem cells that results in lesions such as balanced and unbalanced chromosome rearrangements, -5/del(5q) and/or -7/del(7q), as well as other submicroscopic genetic lesions. Together with epigenetic alterations, these result in dysplasia, clonal expansion, and ultimately myeloid leukemia. Combinations of lesions are required to induce overt leukemia. Altering a small subset of signaling pathways leads to disruption of normal self-renewal, proliferation, differentiation, and apoptotic mechanisms t...
Source: Chemico-Biological Interactions - October 8, 2009 Category: Molecular Biology Authors: Larson RA Tags: Chem Biol Interact Source Type: journals

Stereospecificity In The Cytotoxic Action Of Hexachlorocyclohexane Isomers.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hexachlorocyclohexane (HCH) is a highly recalcitrant organochlorine insecticide known for its chronic toxicity. In spite of many isolated studies a clear mechanism of cytotoxic action of HCH and the structure-toxicity relationship of its isomers is not well understood. We have investigated the toxicity of HCH isomers and its mechanism in Ehrlich Ascites Tumor (EAT) cells. Our studies show differential cytotoxicity of HCH isomers (alpha, beta, gamma, and delta), delta isomer being most toxic and beta the least. HCH-induced cell death was associated with induction of reactive oxygen species (ROS) formation, lipid peroxid...
Source: Chemico-Biological Interactions - October 6, 2009 Category: Molecular Biology Authors: Srivastava A, Shivanandappa T Tags: Chem Biol Interact Source Type: journals

Delphinidin attenuates stress injury induced by oxidized low-density lipoprotein in human umbilical vein endothelial cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Moderate consumption of natural dietary polyphenolic compounds can reduce the risk of cardiovascular diseases. Here we investigated the protective effects of delphinidin against oxidized low-density lipoprotein (oxLDL)-induced damage in human umbilical vein endothelial cells (HUVECs). The MTT assay showed that 2h pre-incubation with delphinidin markedly restored the oxLDL-induced viability loss in HUVECs in a concentration-dependent manner. This effect was accompanied by a significant decrease in intracellular reactive oxygen species. Moreover, delphinidin imposed preventive effects on suppressing the production of lip...
Source: Chemico-Biological Interactions - October 6, 2009 Category: Molecular Biology Authors: Chen CY, Yi L, Jin X, Mi MT, Zhang T, Ling WH, Yu B Tags: Chem Biol Interact Source Type: journals