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Inovio Biomedical Universal DNA Vaccine For Chikungunya Virus Demonstrates Protective Antibody Responses In Monkey ModelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Inovio Biomedical Corporation (NYSE Amex: INO), a leader in DNA vaccine design, development and delivery, announced that the company's SynCon™ Chikungunya virus DNA vaccine induced protective neutralizing antibody responses in a preclinical non-human primate model. Dr. David B. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 20, 2009 Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

Inovio Biomedical Universal DNA Vaccine For Chikungunya Virus Demonstrates Protective Antibody Responses In Monkey ModelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Inovio Biomedical Corporation (NYSE Amex: INO), a leader in DNA vaccine design, development and delivery, announced that the company's SynCon™ Chikungunya virus DNA vaccine induced protective neutralizing antibody responses in a preclinical non-human primate model. Dr. David B. (Source: Immune System / Vaccines News From Medical News Today)
Source: Immune System / Vaccines News From Medical News Today - November 20, 2009 Category: Allergy & Immunology Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

Imported chikungunya virus strains, Taiwan, 2006-2009.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19891886 [PubMed - in process] (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - November 1, 2009 Category: Infectious Diseases Authors: Huang JH, Yang CF, Su CL, Chang SF, Cheng CH, Yu SK, Lin CC, Shu PY Tags: Emerg Infect Dis Source Type: journals

Globally mobile populations and the spread of emerging pathogens.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
During the past decade, the global public health community has been challenged by the emergence and rapid worldwide spread of novel influenza strains, severe acute respiratory syndrome, chikungunya virus, drug-resistant tuberculosis, and other conditions and pathogens. Modern transportation and increased tourism, business travel, and immigration contributed to dissemination of these high-impact pathogens. The effectiveness of interventions such as airport screening, travel restrictions, and other community mitigation measures remains uncertain. However, human migration has occurred for centuries and will continue, desp...
Source: Emerging Infectious Diseases - November 1, 2009 Category: Infectious Diseases Authors: Arguin PM, Marano N, Freedman DO Tags: Emerg Infect Dis Source Type: journals

Chikungunya virus isolated from a returnee to Japan from sri lanka: isolation of two sub-strains with different characteristics.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A large-scale epidemic of chikungunya (CHIK) fever occurred in several Indian Ocean islands in 2004 and spread to India and Sri Lanka. In December 2006, a returnee to Japan from Sri Lanka developed an acute febrile illness. The patient was confirmed to have CHIK fever after reverse transcription-polymerase chain reaction, and specific IgM and IgG detection. CHIK virus was isolated from the serum specimen collected at the acute stage. The isolated virus developed two different sizes of plaques. Two sub-strains with different genetic and biological characteristics were obtained by plaque purification from one isolate. Th...
Source: The American Journal of Tropical Medicine and Hygiene - October 31, 2009 Category: Tropical Medicine Authors: Lim CK, Nishibori T, Watanabe K, Ito M, Kotaki A, Tanaka K, Kurane I, Takasaki T Tags: Am J Trop Med Hyg Source Type: journals

Pan-European Chikungunya surveillance: designing risk stratified surveillance zonesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The first documented transmission of Chikungunya within Europe took place in Italy during the summer of 2007. Chikungunya, a viral infection affecting millions of people across Africa and Asia, can be debilitating and no prophylactic treatment exists. Although imported cases are reported frequently across Europe, 2007 was the first confirmed European outbreak and available evidence suggests that Aedes albopictus was the vector responsible and the index case was a visitor from India. This paper proposed pan-European surveillance zones for Chikungunya, based on the climatic conditions necessary for vector activity and viral ...
Source: International Journal of Health Geographics - October 31, 2009 Category: Global & Universal Authors: Natasha TilstonChris SkellyPhil Weinstein Source Type: journals

Vector Competence of Australian Mosquitoes for Chikungunya VirusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Vector-Borne and Zoonotic Diseases , Vol. 0, No. 0. (Source: Vector-Borne and Zoonotic Diseases)
Source: Vector-Borne and Zoonotic Diseases - October 30, 2009 Category: Infectious Diseases Tags: article Source Type: journals

Emergence of Chikungunya Virus Infection in Orissa, IndiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Vector-Borne and Zoonotic Diseases , Vol. 0, No. 0. (Source: Vector-Borne and Zoonotic Diseases)
Source: Vector-Borne and Zoonotic Diseases - October 29, 2009 Category: Infectious Diseases Tags: article Source Type: journals

Appearance of A226V mutant Chikungunya virus in Coastal Karnataka, India during 2008 outbreakEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chikungunya has resurged in the form of unprecedented explosive epidemic in 2006 after a long gap in India affecting 1.39 million of persons. The disease continued for the next two consecutive years affecting 59,535 and 64,548 persons during 2007 and 2008 respectively. The 2008 outbreak being the second largest among these three years the information regarding the etiology and the mutations involved are useful for further control measures. Among the 2008 outbreaks the Coastal Karnataka accounts for the 46,510 persons. An in-depth investigation of Chikungunya epidemic of Coastal Karnataka, India, 2008 by serology, virus iso...
Source: Virology Journal - October 27, 2009 Category: Virology Authors: Santhosh SrPaban DashManmohan ParidaMohasin KhanP Rao Source Type: journals

Widely Used Virus Assay Shown Unreliable When Compared To Other MethodsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the course of doing research on the mosquito-borne pathogens chikungunya virus and o' nyong-nyong virus, researchers have discovered an inconvenient truth about an assay, strand-specific quantitative real-time PCR (ssqPCR), increasingly being used to detect and measure replicating viral RNA in infected cells and tissues. The method most labs are using for ssqPCR is unreliable. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - October 23, 2009 Category: Science Source Type: news

Present and Future Arboviral Threats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Arthropod-borne viruses (arboviruses) are important causes of human disease nearly worldwide. All arboviruses circulate among wild animals, and many cause disease after spillover transmission to humans and agriculturally important domestic animals that are incidental or dead-end hosts. Viruses such as dengue (DENV) and chikungunya (CHIKV) viruses that have lost the requirement for enzootic amplification now produce extensive epidemics in tropical urban centers. Many arboviruses recently have increased in importance as human and veterinary pathogens using a variety of mechanisms. Beginning in 1999, West Nile virus (WNV)...
Source: Antiviral Research - October 23, 2009 Category: Virology Authors: Weaver SC, Reisen WK Tags: Antiviral Res Source Type: journals

Genetic characterization of 2006–2008 isolates of Chikungunya virus from Kerala, South India, by whole genome sequence analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Chikungunya virus (CHIKV), a positive-stranded alphavirus, causes epidemic febrile infections characterized by severe and prolonged arthralgia. In the present study, six CHIKV isolates (2006 RGCB03, RGCB05; 2007 RGCB80, RGCB120; 2008 RGCB355, RGCB356) from three consecutive Chikungunya outbreaks in Kerala, South India, were analyzed for genetic variations by sequencing the 11798 bp whole genome of the virus. A total of 37 novel mutations were identified and they were predominant in the 2007 and 2008 isolates among the six isolates studied. The previously identified E1 A226V critical mutation, w...
Source: Virus Genes - October 22, 2009 Category: Genetics & Stem Cells Tags: Virus Genes Source Type: journals

Widely used virus assay shown unreliable when compared to other methodsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Virginia Tech) In the course of doing research on the mosquito-borne pathogens chikungunya virus and o' nyong-nyong virus, Virginia Tech researchers have discovered an inconvenient truth about an assay, strand-specific quantitative real-time PCR (ssqPCR), increasingly being used to detect and measure replicating viral RNA in infected cells and tissues. The method most labs are using for ssqPCR is unreliable. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 21, 2009 Category: Global & Universal Source Type: news

From NAT/PI to NAS/PO: preparing for nucleic acid surveillance and product optimizationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The transfusion-transmitted infection (TTI) risk of pathogens for which nucleic acid testing (NAT) has been implemented is now insubstantial compared to other hazards of transfusion. Minimizing the TTI risk of non-tested pathogens is a goal of pathogen inactivation (PI); in particular, the interdiction of emerging pathogens is a major selling point. Incidental to PI is the possibility of eliminating certain patient-oriented procedures, e.g. selectively screening for cytomegalovirus (CMV) or irradiating to prevent transfusion-associated graft-versus-host disease (TA-GVHD). Do NAT and PI introduce new hazards? Perhaps. The p...
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: K. E. Nollet Tags: Papers Source Type: journals

Epidemiology of dengue and chikungunya viruses and their potential impact on the blood supplyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dengue and chikungunya, transmitted by the Aedes mosquitoes, have caught worldwide attention because of increase in the frequency of major epidemics in recent years. Though transmitted by the same vectors, they are caused by different viruses (DENV and CHIKV) that belong to the genus Flavivirus and Alphavirus, respectively. There has been a worldwide resurgence of dengue in the last few decades. Today, it is estimated that it affects at least 50[ndash]100 million people every year. With more than 100 countries, between the 10°C isothermal lines, being endemic, 2·5 billion people are at risk of infection. Facilitated by r...
Source: ISBT Science Series - October 13, 2009 Category: Hematology Authors: L. C. Ng, S. Lam, D. Teo Tags: Papers Source Type: journals

[Paediatric features of Dengue and Chikungunya fevers.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Dengue (Df) and Chikungunya fever (Cf) arbovirosis are booming in the world, because of the plasticity of their pathogens, mutant RNA viruses making the acquisition of sustainable herd immunity and vaccination difficult in humans, and the plasticity of their vectors, the female mosquitoes of the genus Aedes (Stegomya), capable of adapting to different environments. This review summarizes the viral life cycle and epidemiology of these arboviruses, pathogenesis and pediatric aspects of their clinical forms and the basic principles of their treatment and prevention. PMID: 19815395 [PubMed - as supplied by publisher] (...
Source: Archives de Pediatrie - October 5, 2009 Category: Pediatrics Authors: Gérardin P Tags: Arch Pediatr Source Type: journals

Chikungunya Fever: Could an Outbreak Happen Here?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
VAIL, COLO. — Chikungunya fever is a tropical disease few American physicians are familiar with—but that could change quite suddenly, as physicians in temperate northern Italy discovered. (Source: Skin and Allergy News)
Source: Skin and Allergy News - September 30, 2009 Category: Dermatology Authors: BRUCE JANCIN Tags: Infectious Diseases Source Type: journals

Development of field-based real-time reverse transcription-polymerase chain reaction assays for detection of Chikungunya and O'nyong-nyong viruses in mosquitoes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe the development of sensitive and specific real-time RT-PCR assays for detecting CHIK and ONN viral RNA in mosquitoes, which have application for field use. In addition, we compared three methods for primer/probe design for assay development by evaluating their sensitivity and specificity. This comparison resulted in development of virus-specific assays that could detect less than one plaque-forming unit equivalent of each of the viruses in mosquitoes. The use of these assays will aid in arthropod-borne disease surveillance and in the control of the associated diseases. PMID: 19815886 [PubMed - in process] (...
Source: The American Journal of Tropical Medicine and Hygiene - September 30, 2009 Category: Tropical Medicine Authors: Smith DR, Lee JS, Jahrling J, Kulesh DA, Turell MJ, Groebner JL, O'Guinn ML Tags: Am J Trop Med Hyg Source Type: journals

Dealing with low pH: entry and exit of alphaviruses and flaviviruses.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The alphaviruses and flaviviruses include many important human pathogens, such as the dengue, West Nile, and Chikungunya viruses. These enveloped viruses infect cells by a membrane fusion reaction triggered by the low pH in endosomes. Fusion is mediated by viral membrane proteins through their acid-dependent conversion from a dimer on the virus surface to a homotrimer inserted into the host cell membrane. Here we review recent studies on the regulatory mechanisms that silence these fusion proteins during virus exit and that sense low pH and mediate protein refolding during virus entry. We discuss results using truncate...
Source: Trends in Microbiology - September 28, 2009 Category: Microbiology Authors: Martín CS, Liu CY, Kielian M Tags: Trends Microbiol Source Type: journals

Chikungunya outbreak in IndiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
An survey which was taken on August 2009,says that nearly 20,000 people around Saem in tamil nadu,south india are infected with chikungunya virus,this virus affects only people above 15 Yrs. secondary infection is not seen,so an effective drug must me given rather than Chloroquine,which is not effective. (Source: Chikungunya)
Source: Chikungunya - September 25, 2009 Category: Bioinformatics Authors: A.Indhu sree,Abdul Woheid Tags: outbreak|Chikungunya| South india Source Type: research

Development of a consensus microarray method for identification of some highly pathogenic virusesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Some highly pathogenic viruses, such as Chikungunya virus, Japanese encephalitis virus, Yellow fever virus, Dengue virus, Hanta virus, SARS-CoV, and H5N1 avian influenza virus can cause severe infectious diseases. However, the consensus method for detecting these viruses has not been well established. A rapid and sensitive microarray approach for detection of these viruses and a panel of specific probes covering nine genera and 16 virus species were designed. 70-mer oligonucleotides were used at the genus level and 50-mer oligonucleotides were at the species level, respectively. To decrease the interference of the host gen...
Source: Journal of Medical Virology - September 21, 2009 Category: Virology Authors: Kang Xiao-Ping, Li Yong-Qiang, Sun Qing-Ge, Liu Hong, Zhu Qing-Yu, Yang Yin-Hui Tags: Research Article Source Type: journals

Development and evaluation of antigen capture ELISA for early clinical diagnosis of chikungunyaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The resurgence of chikungunya (CHIK) in the form of unprecedented explosive epidemic after a gap of 3 decades in India and Indian Ocean islands is a point of major public health concern. The laboratory diagnosis is essentially based on virus isolation, IgM ELISA, and reverse transcriptase polymerase chain reaction (RT-PCR). Although PCR-based methods are used for early and accurate diagnosis, the high cost of the assay and requirement of thermal cycler limit its application only to referral laboratories. The antibody-based IgM ELISA is found to be cost-effective, but it takes 5 to 6 days for the patient to develo...
Source: Diagnostic Microbiology and Infectious Disease - September 14, 2009 Category: Microbiology Authors: Jyoti Shukla, Mohsin Khan, Mugdha Tiwari, Santhosh Sannarangaiah, Shashi Sharma, Putcha Venkata Lakshmana Rao, Manmohan Parida Tags: Virology Source Type: journals

NEUROLOGICAL REVIEW: Emerging Viral Infections of the Central Nervous System: Part 2Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The first part of this review ended with a discussion of new niches for known viruses as illustrated by viral central nervous system (CNS) disease associated with organ transplant and the syndrome of human herpesvirus 6–associated posttransplant acute limbic encephalitis. In this part, we begin with a continuation of this theme, reviewing the association of JC virus–associated progressive multifocal leukoencephalopathy (PML) with novel immunomodulatory agents. This part then continues with emerging viral infections associated with importation of infected animals (monkeypox virus), then spread of vectors and enh...
Source: Archives of Neurology - September 13, 2009 Category: Neurology Authors: Tyler, K. L. Tags: HIV/AIDS, Viral Infections, Neurology, Neurology, Other, Transplantation, Transplantation, Other, Review, Infectious Diseases Neurological Review Source Type: journals

Chikungunya infection confirmed in a Belgian traveller returning from Phuket (Thailand).Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe the first case of chikungunya in a Belgian traveller returning from Phuket, Thailand and discuss the potential implications of chikungunya cases imported to European countries for patient management and public health. PMID: 19555596 [PubMed - indexed for MEDLINE] (Source: Euro Surveill)
Source: Euro Surveill - September 11, 2009 Category: Infectious Diseases Authors: Bottieau E, Van Esbroeck M, Cnops L, Clerinx J, Van Gompel A Tags: Euro Surveill Source Type: journals

Sporadic cases of chikungunya, Réunion Island, August 2009.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sporadic cases of chikungunya, Réunion Island, August 2009. Euro Surveill. 2009;14(35): Authors: D'Ortenzio E, Grandadam M, Balleydier E, Dehecq JS, Jaffar-Bandjee MC, Michault A, Andriamandimby SF, Reynes JM, Filleul L On 28 August 2009, French authorities reported five cases of chikungunya fever on Reunion Island: three confirmed, one probable, and one suspected case under investigation. All three confirmed patients presented with an acute febrile syndrome, arthralgia, myalgia and cutaneaous rash. All live in the same area on the western side of the island. PMID: 19728980 [PubMed - in process] (Source: Euro Surveill)
Source: Euro Surveill - September 6, 2009 Category: Infectious Diseases Authors: D'Ortenzio E, Grandadam M, Balleydier E, Dehecq JS, Jaffar-Bandjee MC, Michault A, Andriamandimby SF, Reynes JM, Filleul L Tags: Euro Surveill Source Type: journals

Sporadic cases of chikungunya, Réunion Island, August 2009Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
On 28 August 2009, French authorities reported five cases of chikungunya fever on Réunion Island: three confirmed, one probable, and one suspected case under investigation. All three confirmed patients presented with an acute febrile syndrome, arthralgia, myalgia and cutaneaous rash. All live in the same area on the western side of the island. (Source: Eurosurveillance latest news)
Source: Eurosurveillance latest news - September 3, 2009 Category: Infectious Diseases Source Type: journals

Larval Environmental Temperature and the Susceptibility of Aedes albopictus Skuse (Diptera: Culicidae) to Chikungunya VirusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Vector-Borne and Zoonotic Diseases , Vol. 0, No. 0. (Source: Vector-Borne and Zoonotic Diseases)
Source: Vector-Borne and Zoonotic Diseases - September 2, 2009 Category: Infectious Diseases Tags: article Source Type: journals

Comparative Role of Aedes albopictus and Aedes aegypti in the Emergence of Dengue and Chikungunya in Central AfricaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Vector-Borne and Zoonotic Diseases , Vol. 0, No. 0. (Source: Vector-Borne and Zoonotic Diseases)
Source: Vector-Borne and Zoonotic Diseases - September 2, 2009 Category: Infectious Diseases Tags: article Source Type: journals

Novel infectious agents causing uveitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract In any patient with uveitis, an infectious cause should be ruled out first. The differential diagnosis includes multiple well-known diseases including herpes, syphilis, toxoplasmosis, tuberculosis, bartonellosis, Lyme disease, and others. However, clinician should be aware of emerging infectious agents as potential causes of systemic illness and also intraocular inflammation. Air travel, immigration, and globalization of business have overturned traditional pattern of geographic distribution of infectious diseases, and therefore one should work locally but think globally. This review recapitulates t...
Source: International Ophthalmology - August 27, 2009 Category: Opthalmology Tags: International Ophthalmology Source Type: journals

Emerging Infections: Chikungunya Fever: An Epidemiological Review of a Re‐Emerging Infectious DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical Infectious Diseases, Volume 49, Issue 6, 15 September 2009. Chikungunya fever is an acute febrile illness associated with severe, often debilitating polyarthralgias. The disease is caused by Chikungunya virus (CHIKV), an arthropod‐borne virus that is transmitted to humans primarily via the bite of an infected mosquito. Since a re‐emergence of CHIKV in 2004, the virus has spread into novel locations, such as Europe, and has led to millions of cases of disease throughout countries in and around the Indian Ocean. The risk of importation of CHIKV into new areas is ever present because of the high attack rate...
Source: Clinical Infectious Diseases Latest Issue - August 20, 2009 Category: Infectious Diseases Tags: article EMERGING INFECTIONS Source Type: journals

Chikungunya virus of Asian and Central/East African genotypes in MalaysiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The CHIKV strain causing the largest Malaysian outbreak is of the Central/East African genotype. The presence of the A226V mutation, which enhances transmissibility of CHIKV by Aedes albopictus, may explain the extensive spread especially in rural areas. Serum cross-neutralisation of different genotypes may aid potential vaccines and limit the effect of future outbreaks. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - August 16, 2009 Category: Virology Authors: I-Ching Sam, Yoke Fun Chan, Shie Yien Chan, Shih Keng Loong, Hock Khim Chin, Poh Sim Hooi, Rajasekaram Ganeswrie, Sazaly AbuBakar Tags: Short communications Source Type: journals

[Letters] Rheumatoid arthritis after Chikungunya fever: a prospective follow-up study of 21 casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Annals of the Rheumatic Diseases)
Source: Annals of the Rheumatic Diseases - August 11, 2009 Category: Rheumatology Authors: Bouquillard, E, Combe, B Tags: Letters Source Type: journals

NEUROLOGICAL REVIEW: Emerging Viral Infections of the Central Nervous System: Part 1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this 2-part review, I will focus on emerging virus infections of the central nervous system (CNS). Part 1 will introduce the basic features of emerging infections, including their definition, epidemiology, and the frequency of CNS involvement. Important mechanisms of emergence will be reviewed, including viruses spreading into new host ranges as exemplified by West Nile virus (WNV), Japanese encephalitis (JE) virus, Toscana virus, and enterovirus 71 (EV71). Emerging infections also result from opportunistic spread of viruses into known niches, often resulting from attenuated host resistance to infection. This process is...
Source: Archives of Neurology - August 9, 2009 Category: Neurology Authors: Tyler, K. L. Tags: Viral Infections, Neurology, Encephalitis, Neuromuscular diseases, Neurology, Other, Dermatology, Dermatologic Disorders, Bites and Stings, Review, Infectious Diseases Neurological Review Source Type: journals

Chikungunya Fever: An Epidemiological Review of a Re‐Emerging Infectious DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical Infectious Diseases, Volume 0, Issue 0, Page 000, Latest Articles. Chikungunya fever is an acute febrile illness associated with severe, often debilitating polyarthralgias. The disease is caused by Chikungunya virus (CHIKV), an arthropod‐borne virus that is transmitted to humans primarily via the bite of an infected mosquito. Since a re‐emergence of CHIKV in 2004, the virus has spread into novel locations, such as Europe, and has led to millions of cases of disease throughout countries in and around the Indian Ocean. The risk of importation of CHIKV into new areas is ever present because of the high atta...
Source: Clinical Infectious Diseases Latest Issue - August 7, 2009 Category: Infectious Diseases Tags: article EMERGING INFECTIONS Source Type: journals

Clinical features and epidemiology of chikungunya infection in Singapore.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chikungunya is a re-emerging mosquito-borne viral infection that has spread from East Africa to Indian Ocean islands and re-emerged in India since 2004. In Malaysia, chikungunya re-emerged after a hiatus of seven years, causing a localised outbreak in a north-western coastal town in 2006 and subsequently widespread outbreaks in 2008. Since the first local outbreak of chikungunya in Singapore in January 2008, chikungunya infections have been increasingly reported in Singapore. In this case series, five patients aged 37-62 years, with chikungunya infection confirmed in August 2008, were reported. Three of the five were m...
Source: Singapore Medical Journal - July 31, 2009 Category: Journals (General) Authors: Ng KW, Chow A, Win MK, Dimatatac F, Neo HY, Lye DC, Leo YS Tags: Singapore Med J Source Type: journals

Entomologic and virologic investigation of Chikungunya, Singapore.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report highlights the use of entomologic and virologic data to assist in the control of chikungunya in disease-endemic areas. PMID: 19751586 [PubMed - in process] (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - July 31, 2009 Category: Infectious Diseases Authors: Ng LC, Tan LK, Tan CH, Tan SS, Hapuarachchi HC, Pok KY, Lai YL, Lam-Phua SG, Bucht G, Lin RT, Leo YS, Tan BH, Han HK, S Ooi PL, James L, Khoo SP Tags: Emerg Infect Dis Source Type: journals

Cutaneous manifestations in patients suspected of chikungunya diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions : To conclude, a plethora of cutaneous manifestations were noted in suspected cases of chikungunya disease. Genital ulcers, to the best of our knowledge, have not been reported during the earlier epidemics but have been reported by others during the present one. (Source: Indian Journal of Dermatology)
Source: Indian Journal of Dermatology - July 30, 2009 Category: Dermatology Authors: Soma Prashant, AS Kumar, DD Mohammed Basheeruddin, TN Chowdhary, B Madhu Source Type: journals

The role of environmental and individual factors in the social epidemiology of chikungunya disease on Mayotte Island.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article examines the role of environmental and individual factors in the social epidemiology of chikungunya disease on the island of Mayotte (South-western Indian Ocean). In an epidemic setting, an interdisciplinary study combining interviews, observations, and serological tests was conducted to: (1) estimate the frequency and social distribution of chikungunya disease and (2) identify its principal cognitive, behavioral, and environmental determinants within a stratified random sample of the Mayotte population (n=888). Semi-parametric tests and multiple correspondence analyses were used to describe the statistical re...
Source: Health & Place - July 30, 2009 Category: Environmental Health Authors: Raude J, Setbon M Tags: Health Place Source Type: journals

Amelioration of alphavirus-induced arthritis and myositis in a mouse model by treatment with bindarit, an inhibitor of monocyte chemotactic proteinsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Alphaviruses such as chikungunya virus, Sindbis virus, o'nyong-nyong virus, Mayaro virus, and Ross River virus (RRV), are commonly associated with arthralgias and overt arthritides worldwide. Understanding the processes by which arthritogenic viruses cause disease is a prerequisite in the quest for better treatments. In this regard, we have recently established that monocyte/macrophages are mediators of alphavirus-induced arthritis in mice. We hypothesized that chemokines associated with monocyte/macrophage recruitment may play an important role in disease. The aim of the present investigations was to determine whether bin...
Source: Arthritis and Rheumatism - July 29, 2009 Category: Rheumatology Authors: Nestor E. Rulli, Angelo Guglielmotti, Giorgina Mangano, Michael S. Rolph, Claudia Apicella, Ali Zaid, Andreas Suhrbier, Suresh Mahalingam Tags: Myositis Source Type: journals

Systemic involvements and fatalities during Chikungunya epidemic in India, 2006Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Chikungunya infection can cause systemic complications and probably deaths, especially in elderly adults. (Source: Journal of Clinical Virology)
Source: Journal of Clinical Virology - July 28, 2009 Category: Virology Authors: Babasaheb V. Tandale, Padmakar S. Sathe, Vidya A. Arankalle, R.S. Wadia, Rahul Kulkarni, Sudhir V. Shah, Sanjeev K. Shah, Jay K. Sheth, A.B. Sudeep, Anuradha S. Tripathy, Akhilesh C. Mishra Tags: Full length articles Source Type: journals

International diagnostic accuracy study for the serological detection of chikungunya virus infectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clin Microbiol Infect 2009 External quality assurance for serological detection of chikungunya virus infection was performed to assess the diagnostic quality of expert laboratories. Of 30 participants, only six correctly analysed all reference samples with their respective tests. Thirteen laboratories gave at least 85% correct results, and 11 laboratories 75% or less. IgM antibodies were detected less frequently than IgG antibodies (p (Source: Clinical Microbiology and Infection)
Source: Clinical Microbiology and Infection - July 15, 2009 Category: Microbiology Authors: M. Niedrig, H. Zeller, I. Schuffenecker, C. Drosten, P. Emmerich, L. Rumer, O. Donoso-Mantke Source Type: journals

Blood-Feeding Behavior of Aedes albopictus, a Vector of Chikungunya on La RéunionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Vector-Borne and Zoonotic Diseases , Vol. 0, No. 0. (Source: Vector-Borne and Zoonotic Diseases)
Source: Vector-Borne and Zoonotic Diseases - July 9, 2009 Category: Infectious Diseases Tags: article Source Type: journals

Cutaneous manifestations in patients suspected of chikungunya diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions : To conclude, a plethora of cutaneous manifestations were noted in suspected cases of chikungunya disease. Genital ulcers, to the best of our knowledge, have not been reported during the earlier epidemics but have been reported by others during the present one. (Source: Indian Journal of Dermatology)
Source: Indian Journal of Dermatology - July 5, 2009 Category: Dermatology Authors: Prashant Soma, Kumar A S, Mohammed Basheeruddin D D, Chowdhary T N, Madhu B Source Type: journals

Detection of novel insect flavivirus sequences integrated in Aedes albopictus (Diptera: Culicidae) in Northern ItalyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The presence of DNA sequences integrated from a new flavivirus related to Cell Fusing Agent and Kamiti River Virus was identified in wild Aedes albopictus mosquito populations from the provinces of Trentino and Padova, Northern Italy. Field work was developed during August-October 2007 with BG-traps, and mosquitoes were screened for flavivirus and alphavirus. No alphavirus was detected, indicating that Chikungunya virus is not present in these mosquitoes in Trentino and Padova area. However, 21% of the pools were positive for flavivirus, further recognised with BLAST as similar to Kamiti River Virus. Phylogenetical analysi...
Source: BioMed Central - July 4, 2009 Category: Journals (General) Authors: David RoizAna VazquezMari Paz Sanchez-SecoAntonio TenorioAnnapaola Rizzoli Source Type: journals

[Original articles] Concurrent outbreaks of Chikungunya and Dengue fever in Kandy, Sri Lanka, 2006-07: a comparative analysis of clinical and laboratory featuresEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Most of the clinical and laboratory features of patients with Chikungunya and Dengue fever are similar. Arthritis is the pathgnomonic sign in patients with Chikungunya fever. (Source: Postgraduate Medical Journal)
Source: Postgraduate Medical Journal - July 4, 2009 Category: Journals (General) Authors: Kularatne, S A M, Gihan, M C, Weerasinghe, S C, Gunasena, S Tags: Drugs: infectious diseases, Travel medicine, Tropical medicine (infectious diseases), Headache (including migraine), Pain (neurology), Clinical diagnostic tests Original articles Source Type: journals

Prophylaxis and Therapy for Chikungunya Virus InfectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Administration of CHIKV immunoglobulins may constitute a safe and efficacious prevention strategy and treatment for individuals exposed to CHIKV who are at risk of severe infection, such as neonates born to viremic mothers and adults with underlying conditions. These results provide a proof‐of‐concept for purifying human immunoglobulins from plasma samples from patients in the convalescent phase of an emerging infectious disease for which neither prevention nor treatment is available. (Source: The Journal of Infectious Diseases Latest Issue)
Source: The Journal of Infectious Diseases Latest Issue - July 2, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals

Chikungunya: First Steps Toward Specific Treatment and ProphylaxisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The Journal of Infectious Diseases, Volume 0, Issue 0, Page 000, Latest Articles. (Source: The Journal of Infectious Diseases Latest Issue)
Source: The Journal of Infectious Diseases Latest Issue - July 2, 2009 Category: Infectious Diseases Tags: article EDITORIAL COMMENTARY Source Type: journals

Clinical and molecular characterization of chikungunya virus in South Thailand.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In 2008, an outbreak of chikungunya virus (CHIKV) occurred in Narathiwat province, south Thailand. To determine the clinical significance, molecular epidemiology and evolutionary origin of the CHIKV causing this outbreak, 47 patients who had been admitted to Narathiwatratchanakharin provincial hospital due to acute febrile illness were enrolled in this study. Sera were tested for IgM antibodies, and RT-PCR was performed for CHIKV and dengue virus. We diagnosed 10 patients with CHIKV infection and 5 with dengue virus infection. Joint pain is a significant symptom of chikungunya fever. Five strains of CHIKV were isolated...
Source: Japanese Journal of Infectious Diseases - June 30, 2009 Category: Infectious Diseases Authors: Theamboonlers A, Rianthavorn P, Praianantathavorn K, Wuttirattanakowit N, Poovorawan Y Tags: Jpn J Infect Dis Source Type: journals

Co-infections with chikungunya virus and dengue virus in Delhi, India.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aedes aegypti mosquitoes are common vectors for dengue virus and chikungunya virus. In areas where both viruses cocirculate, they can be transmitted together. During a dengue outbreak in Delhi in 2006, 17 of 69 serum samples were positive for chikungunya virus by reverse transcription-PCR; 6 samples were positive for both viruses. PMID: 19624923 [PubMed - in process] (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - June 30, 2009 Category: Infectious Diseases Authors: Chahar HS, Bharaj P, Dar L, Guleria R, Kabra SK, Broor S Tags: Emerg Infect Dis Source Type: journals

Failure to demonstrate experimental vertical transmission of the epidemic strain of Chikungunya virus in Aedes albopictus from La Réunion Island, Indian Ocean.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, Ae. albopictus originating from La Réunion were orally infected with a blood-meal containing 10(8) pfu/mL of the CHIKV epidemic strain (CHIKV 06.21). Eggs from the first and second gonotrophic cycles were collected and raised to the adult stage. The infectious status of the progeny was checked (i) by immunofluorescence on head squashes of individual mosquitoes to detect the presence of viral particles or (ii) by quantitative RT-PCR on mosquito pools to detect viral RNA. We analysed a total of 1,675 specimens from the first gonotrophic cycle and 1,709 from the second gonotrophic cycle without detecting a...
Source: Memorias do Instituto Oswaldo Cruz - June 30, 2009 Category: Infectious Diseases Authors: Vazeille M, Mousson L, Failloux AB Tags: Mem Inst Oswaldo Cruz Source Type: journals