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Irritable bowel syndrome: Role of food in pathogenesis and managementEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Patients with the irritable bowel syndrome (IBS) commonly report the precipitation of symptoms on food ingestion. Though the role of dietary constituents in IBS has not been extensively studied, food could contribute to symptom onset or even the causation of IBS through a number of mechanisms. First, the physiological response of the intestine to food ingestion could precipitate symptoms in predisposed individuals; second, there is some evidence that allergy or intolerance to a particular food can produce IBS-like symptoms, third, certain foods may alter the composition of the luminal milieu, either directly or indirectly ...
Source: Chinese Journal of Digestive Diseases - October 28, 2009 Category: Gastroenterology Authors: Ashraf MORCOS, Ted DINAN, Eamonn MM QUIGLEY Tags: Review Article Source Type: journals

CorrigendumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - October 28, 2009 Category: Gastroenterology Tags: Corrigendum Source Type: journals

Sclerosing encapsulating peritonitis associated with propranolol usage: A case report and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - October 28, 2009 Category: Gastroenterology Authors: Sumit KALRA, Antwan ATIA, Jason McKINNEY, Thomas R BORTHWICK, Roger D SMALLIGAN Tags: Case Report Source Type: journals

A prospective study of the efficacy of endoscopic biliary stenting on common bile duct stonesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Endoscopic biliary stenting was not a definitive treatment of choledocholithiasis. It may be an option for patients clinically unfit for definitive treatment. (Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - October 28, 2009 Category: Gastroenterology Authors: Ke Wei LI, Xi Wen ZHANG, Jun DING, Tao CHEN, Jian WANG, Wei Jin SHI Tags: Original Articles Source Type: journals

The role of entecavir in preventing hepatitis B recurrence after liver transplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: This study shows that entecavir combined with low dosages of HBIG is effective and safe in preventing hepatitis B recurrence after liver transplantation, but its long-term effect is still under investigation and a large-sample study will be carried out in the future. (Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - October 28, 2009 Category: Gastroenterology Authors: Zhi Feng XI, Qiang XIA, Jian Jun ZHANG, Xiao Song CHEN, Long Zhi HAN, Xin WANG, Cong Huan SHEN, Yi LUO, Tian Yu XIN, Si Yue WANG, De Kai QIU Tags: Original Articles Source Type: journals

Nonalcoholic fatty liver disease: Quantitative assessment of liver fat content by computed tomography, magnetic resonance imaging and proton magnetic resonance spectroscopyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: CT, MR imaging and 1H MRS were effective methods for the quantitative assessment of LFC. The MR imaging, especially 1H MRS, would be used more frequently in the clinical evaluation of fatty liver and 1H MRS could more accurately reflect the severity of fatty liver. (Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - October 28, 2009 Category: Gastroenterology Authors: Liang ZHONG, Jie Jun CHEN, Jie CHEN, Lei LI, Zhi Qian LIN, Wen Jing WANG, Jian Rong XU Tags: Original Articles Source Type: journals

Cholesterol metabolism and expression of its relevant genes in cultured steatotic hepatocytesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Cholesterol accumulation is probably due to the upregulated expression of the relevant genes in the cholesterol synthesis of the steatotic hepatocytes. (Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - October 28, 2009 Category: Gastroenterology Authors: Xiao Hong WANG, Yan TIAN, Zhao Jun GUO, Zhu Ping FAN, De Kai QIU, Min De ZENG Tags: Original Articles Source Type: journals

Clinical features and spiral computed tomography analysis of undifferentiated embryonic liver sarcoma in adultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: UELS showed a solitary and predominantly cystic or multicystic appearance on CT imaging compared with ultrasound (US) from the medical literature, which shows a predominantly hypoechoic mass. The laboratory tests were normal or mildly abnormal despite the presence of the large mass. The combination of these clinical features and CT findings together with those of US are helpful in making a prospective diagnosis. (Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - October 28, 2009 Category: Gastroenterology Authors: Lian YANG, Li Bo CHEN, Jie XIAO, Ping HAN Tags: Original Articles Source Type: journals

Do scattered white spots in the duodenum mark a specific gastrointestinal pathology?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Histopathological examinations should be provided for each patient with SWS in the duodenum to assess the etiology. (Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - October 28, 2009 Category: Gastroenterology Authors: İbrahim BIYIKOĞLU, Ayşegül BABALI, Başak ÇAKAL, Seyfettin KÖKLÜ, Levent FILIK, Müzeyyen H ASTARCI, Hüseyin ÜSTÜN, Yücel ÜSTÜNDAĞ, ERDEM AKBAL Tags: Original Articles Source Type: journals

Interventional effect of Ginkgo biloba extract on the progression of gastric precancerous lesions in ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Ginkgo biloba extract can increase anti-oxidative activity and inhibit the progression of gastric precancerous lesions via the regulation of cell proliferation and apoptosis. (Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - October 28, 2009 Category: Gastroenterology Authors: Xiao Yun JIANG, Li Ping QIAN, Xiao Juan ZHENG, Yu Ye XIA, Yi Bin JIANG, Da Yu SUN Tags: Original Articles Source Type: journals

Role of Helicobacter pylori infection on neuronal expression in the stomach and spinal cord of a murine modelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: H. pylori infection induced different degrees of gastric mucosal inflammation in the murine model. Both early and chronic infection groups of mice showed enhanced neuronal expressions of fos, VIP and CGRP of stomach and spinal cord and these could form a basis for appearance of functional dyspeptic symptoms in patients with H. pylori infection. (Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - October 28, 2009 Category: Gastroenterology Authors: Xiao Bo LI, Hui Min CHEN, Hong LU, Qing ZHENG, Xiao Yu CHEN, Yan Shen PENG, Zhi Zheng GE, Wen Zhong LIU Tags: Original Articles Source Type: journals

Ectopic expression of guanylyl cyclase C in gastric cancer as a potential biomarker and therapeutic targetEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The over-expression of GCC has been detected in intestinal type GC. GCC siRNA can effectively inhibit the proliferation and invasion of SGC-7901 cells and induce cell apoptosis. GCC might be a novel biomarker and therapeutic target for GC. (Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - October 28, 2009 Category: Gastroenterology Authors: Zhen Biao MAO, Jian Feng ZHANG, Zhong XU, Hui Jun ZHU, Jian Guo ZHANG, Zheng Ping PAN, Feng XIAO, Jun Ling YANG Tags: Original Articles Source Type: journals

Association of the human leukocyte antigen class II alleles with chronic atrophic gastritis and gastric carcinoma in KoreansEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Our findings strongly imply an association between HLA class II alleles and the risk of CAG development and GC progression in Koreans. (Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - October 28, 2009 Category: Gastroenterology Authors: Hae-Wan LEE, Ki-Baik HAHM, Jeong Sang LEE, Young-Su JU, Kee Myung LEE, Kyung Wha LEE Tags: Original Articles Source Type: journals

RNAi-mediated silencing of ezrin gene reverses malignant behavior of human gastric cancer cell line SGC-7901Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Ezrin gene targeting by RNAi can inhibit the metastatic growth and migration of SGC-7901 human gastric cancer cells. (Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - October 28, 2009 Category: Gastroenterology Authors: Hong Jian WANG, Jin Shui ZHU, Qiang ZHANG, Hua GUO, Yun Hai DAI, Xiao Peng XIONG Tags: Original Articles Source Type: journals

Meta-analysis: The efficacy and safety of monoclonal antibody targeted to epidermal growth factor receptor in the treatment of patients with metastatic colorectal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Our results confirmed that monoclonal antibody targeted to EGFR could be effective in increasing response rates and could be a key therapeutic agent in the optimal treatment of mCRC, despite a moderate increase in grades 3[ndash]4 adverse events. (Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - October 28, 2009 Category: Gastroenterology Authors: Fang NIE, Jun SHEN, Jin Lu TONG, Xi Tao XU, Ming Ming ZHU, Zhi Hua RAN Tags: Meta-Analysis Source Type: journals

Helicobacter pylori infection, host genetics and gastric cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Helicobacter pylori infects half the world's population and is responsible for a considerable global health burden, including peptic ulcer disease and gastric cancer. The infection causes a chronic gastritis, the severity and distribution of which determine the clinical outcome. Bacterial, environmental and host genetic factors combine to define the degree of gastric damage. Most patients have a limited mild pan-gastritis with no significant clinical consequences. Antral-predominant gastritis is associated with high gastric acid output and an increased risk of duodenal ulcers. Corpus-predominant gastritis is associated wit...
Source: Chinese Journal of Digestive Diseases - July 24, 2009 Category: Gastroenterology Authors: Anne-Marie SHANKS, Emad M. EL-OMAR Tags: Leading Article Source Type: journals

Huge primary osteosarcoma of the liver presenting an aggressive recurrent pattern following surgical resectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - July 22, 2009 Category: Gastroenterology Authors: Seong Heum PARK, Sae Byeol CHOI, Wan Bae KIM, Tae-Jin SONG Tags: Case report Source Type: journals

Giant esophageal squamous papilloma: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Esophageal papilloma is a rare disorder that may cause hypopharyngeal symptoms. This patient was a 56-year-old man who presented with cough and choking symptoms. After the initial negative laryngoscopy, a fiberoptic endoscopy revealed a mass originating from the hypopharyngeal area, which was resected surgically and found to be non-malignant. (Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - July 22, 2009 Category: Gastroenterology Authors: Sayed Abbas TABATABAEI, Noshin Afshar MOGHADAM, Mojtaba AHMADINEJAD, Amir MIRMOHAMMADSADEGHI, Hassan MASOUDPOUR, Peyman ADIBI Tags: Case report Source Type: journals

Pulmonary miliary tuberculosis and intestinal tuberculosis co-infected with AIDSEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - July 22, 2009 Category: Gastroenterology Authors: Shao Ping HUANG, Yu Jie ZHAO, Shui Hua LU, Ji Lin CHENG, Yan Ling FENG Tags: Case report Source Type: journals

Endoscopic drainage and endoscopic necrosectomy in the management of symptomatic pancreatic collectionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Endoscopic drainage and endoscopic necrosectomy are safe and effective techniques for the treatment of symptomatic pancreatic fluid collection. (Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - July 22, 2009 Category: Gastroenterology Authors: Tiing Leong ANG, Eng Kiong TEO, Kwong Ming FOCK Tags: Original Article Source Type: journals

Post-cholecystectomy cystic duct stump leak: a preventable morbidityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The CDSL of 0.44% was comparable to the reported incidence in the literature. Endoscopic management remains the treatment of choice. Emergency cholecystectomies seem to have a higher incidence of CDSL. (Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - July 22, 2009 Category: Gastroenterology Authors: Irshad Ahammed A. SHAIKH, Harun THOMAS, Kishore JOGA, A. Ibrahim AMIN, Thomas DANIEL Tags: Original Article Source Type: journals

Diagnostic value of a group of biochemical markers of liver fibrosis in patients with non-alcoholic steatohepatitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Our study showed that the degree of liver fibrosis was significantly correlated with age, TNF-[alpha] and type IV collagen concentrations. The level of HA and type IV collagen could differentiate between mild (F1[ndash]2) and advanced fibrosis (F3[ndash]4). (Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - July 22, 2009 Category: Gastroenterology Authors: C. Rinaldi A. LESMANA, Irsan HASAN, Unggul BUDIHUSODO, Rino A. GANI, Ening KRISNUHONI, Nurul AKBAR, Laurentius A. LESMANA Tags: Original Article Source Type: journals

Drug-induced liver disease: an 8-year study of patients from one gastroenterological departmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: A thorough history of medication should be taken in all patients presenting with abnormal hepatic test results. Chinese medicinal herbs were the most frequent hepatotoxic factor in our patients, although the liver injury was not severe in most cases and was relieved after the prompt withdrawal of the suspected drug. (Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - July 22, 2009 Category: Gastroenterology Authors: Yi Ping WANG, Bin SHI, Yue Xiang CHEN, Jing XU, Cai Feng JIANG, Wei Fen XIE Tags: Original Article Source Type: journals

MicroRNA expression profile in non-cancerous colonic tissue associated with lymph node metastasis of colon cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The non-cancerous colonic tissues from colon cancer patients with lymph node metastasis have a significantly different microRNA expression profile compared to that from colon cancer patients without lymph node metastasis. The differentially expressed microRNA could have relevance to the lymph node metastasis of colon cancer and may provide a simple profiling method to assist in identifying patients with lymph node metastasis. Besides, these data might offer new ideas for preventing and controlling lymphatic metastasis in colon cancer. (Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - July 22, 2009 Category: Gastroenterology Authors: Zhi Ming HUANG, Ji YANG, Xiao Ying SHEN, Xiao Yan ZHANG, Fan Sheng MENG, Jiang Tao XU, Bao Feng ZHANG, Heng Jun GAO Tags: Original Article Source Type: journals

SLC22A4 and SLC22A5 gene polymorphisms and Crohn's disease in the Chinese Han populationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: In contrast to the Caucasian population, SLC22A4 and SLC22A5 genes are unlikely to play a major role in susceptibility to CD in the Chinese Han population. (Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - July 22, 2009 Category: Gastroenterology Authors: Yun FENG, Ping ZHENG, Hang ZHAO, Kai WU Tags: Original Article Source Type: journals

Effect of parthenolide on proliferation and apoptosis in gastric cancer cell line SGC7901Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: These results suggest that possibly via activation of the mitochondrial pathway, PAR causes mitochondrial damage leading to the release of cytochrome C and by regulating the expression of the Bcl-2 family of proteins and activating caspases which leads to results in apoptotic cell death in SGC7901 cells. Our results might be helpful in formulating new therapeutic approaches using Chinese herbal medicine. (Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - July 22, 2009 Category: Gastroenterology Authors: Li Jie ZHAO, Yong Hong XU, Yan LI Tags: Original Article Source Type: journals

Long-term RNA interference and its application to hepatitis B virusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
RNA interference (RNAi) is an ancient defensive mechanism in eukaryotes to control gene expressing and defend their genomes from foreign invaders. It refers to the phenomenon that double-stranded RNA results in the sequence-specific silencing of target gene expression. Although it was documented in a relatively short time ago, intensive research has facilitated making its mechanism clear. Researchers have found that it was a powerful tool for analyzing the functions of genes and treating tumors, infectious diseases and genetic abnormalities that are associated with a dominant gene defect. However, delivery in vivo, low blo...
Source: Chinese Journal of Digestive Diseases - July 22, 2009 Category: Gastroenterology Authors: Jin Shui PAN, Xiao Zhong WANG, Jian Lin REN Tags: Review Source Type: journals

African, Asian or Indian enigma, the East Asian Helicobacter pylori: facts or medical mythsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Helicobacter pylori is etiologically related to peptic ulcer disease and gastric adenocarcinomas. Reports of geographical enigmas (African, Asian, Indian and Costa Rican enigmas) are based on perceptions that clinical presentations in a population or region are not as the authors expected. We discuss the background for these enigmas and examine the evidence whether they are real or are medical myths. The African enigma was challenged almost as soon as it was proposed and recent analyses of endoscopic data have confirmed it is a myth, as H. pylori-related diseases occur in Africa at the expected frequencies. The Asian and I...
Source: Chinese Journal of Digestive Diseases - April 22, 2009 Category: Gastroenterology Authors: David Y GRAHAM, Hong LU, Yoshio YAMAOKA Tags: Leading Article Source Type: journals

Occult bleeding of small bowel: endovascular embolization and literature reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - April 21, 2009 Category: Gastroenterology Authors: Aylin HASANEFENDIOGLU BAYRAK, Murat CANTASDEMIR, Ahmet BAS, Furuzan NUMAN Tags: Case report Source Type: journals

Recurrent gallstone ileus: time to change our surgery?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - April 21, 2009 Category: Gastroenterology Authors: J Edward F FITZGERALD, Lucy A FITZGERALD, Charles A MAXWELL-ARMSTRONG, Adam J BROOKS Tags: Case report Source Type: journals

Validity of FibroScan values for predicting hepatic fibrosis stage in patients with chronic HCV infectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: FibroScan values gave a good correlation with various markers of fibrosis and increased proportionally with the progression of the hepatic fibrosis stage. A FibroScan value of 15 kPa was found to be a significant separation limit for differentiating advanced fibrosis stages (F3 and F4) from the milder stages (F0[ndash]F2). FibroScan values are clinically useful for predicting the fibrosis stages and helpful in managing interferon therapy in patients with chronic hepatitis C. (Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - April 21, 2009 Category: Gastroenterology Authors: Ryosuke TAKEMOTO, Makoto NAKAMUTA, Yoko AOYAGI, Tatsuya FUJINO, Kenichiro YASUTAKE, Kotaro KOGA, Tsuyoshi YOSHIMOTO, Toshihiko MIYAHARA, Kunitaka FUKUIZUMI, Yoshiyuki WADA, Yuko TAKAMI, Hideki SAITSU, Naohiko HARADA, Manabu NAKASHIMA, Munechika ENJOJI Tags: Original Article Source Type: journals

Hepatitis B virus DNA in patients with hepatitis B-related liver cirrhosis with or without hepatocellular carcinomas: a matched case-control studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
OBJECTIVE: The relationship between serum viremia and the development of hepatocellular carcinoma (HCC) in patients with hepatitis B virus (HBV)-related cirrhosis remains unclear. We aimed at calculating odds ratios (OR) for the presence of HCC over a range of HBV DNA levels in these patients.METHODS: Patients were identified retrospectively and 155 pairs of matched, treatment-naive HBV-related cirrhotic patients with and without HCC were recruited. Their serum HBV DNA levels were measured at HCC diagnosis, or at the equivalent age in non-HCC patients, and correlations between the presence of HCC and different DNA levels ...
Source: Chinese Journal of Digestive Diseases - April 21, 2009 Category: Gastroenterology Authors: Jing XU, Yong LIN, Yi Ping WANG, Yue Xiang CHEN, Bin SHI, Jian LU, Wei Fen XIE Tags: Original Article Source Type: journals

A 7-year study of lamivudine therapy for hepatitis B virus e antigen-positive chronic hepatitis B patients in ChinaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Lamivudine is effective and tolerable for chronic hepatitis B. (Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - April 21, 2009 Category: Gastroenterology Authors: Guang Bi YAO, Mei ZHU, Zhen Yu CUI, Bao En WANG, Ji Lu YAO, Ming De ZENG Tags: Original Article Source Type: journals

Identification of NOD2/CARD15 mutations in Malaysian patients with Crohn's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: These findings suggest the presence of novel DPM in the NOD2/CARD15 gene in Asian patients with CD. (Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - April 21, 2009 Category: Gastroenterology Authors: Kek Heng CHUA, Ida HILMI, Ching Ching NG, Tzy Lui ENG, Shanthi PALANIAPPAN, Way Seah LEE, Khean-Lee GOH Tags: Original Article Source Type: journals

Polymorphism of thymidylate synthase gene and chemosensitivity of 5-fluorouracil regimen in metastatic gastrointestinal cancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Our study suggested that polymorphism of 3R/3R was more common in Chinese gastrointestinal cancer patients. Patients with a TS polymorphism expressed as 2R/3R might be more sensitive to 5-FU regimen than those with a polymorphism expressed as 3R/3R. (Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - April 21, 2009 Category: Gastroenterology Authors: Yue Hong CUI, Tian Shu LIU, Rong Yuan ZHUANG, Hen Jun GAO, Hong LI Tags: Original Article Source Type: journals

Clinical study of the relationship between inflammatory bowel diseases and colorectal neoplasmsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The incidence of IBD has kept on rising in recent years. Clinically, UC patients have more probability of developing colorectal cancer than CD patients. The main risk factors of developing colorectal cancer in UC patients are frequent relapses, weight loss and other complications. (Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - April 21, 2009 Category: Gastroenterology Authors: Yu Jie ZHAO, Yao Zong YUAN Tags: Original Article Source Type: journals

Association of the CagA status of Helicobacter pylori and serum levels of interleukin (IL)-17 and IL-23 in duodenal ulcer patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: These results showed higher IL-17 and IL-23 serum levels in H. pylori-infected participants than in the control group. In the DU group the expression of IL-17 was influenced by the CagA factor. (Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - April 21, 2009 Category: Gastroenterology Authors: Abdollah JAFARZADEH, Vahid MIRZAEE, Hossain AHMAD-BEYGI, Maryam NEMATI, Mohammad Taghi REZAYATI Tags: Original Article Source Type: journals

Analysis of whole genomic expression profiles of Helicobacter pylori related chronic atrophic gastritis with IL-1B-31CC/-511TT genotypesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The H. pylori-related CAG with IL-1B-31CC/-511TT genotypes has shown to be the more malignant phenotype than H. pylori negative CAG with IL-1B-31CC/-511TT genotypes. Mitochondrial energy metabolism probably plays a crucial role as it is the molecular mechanism of host[ndash]bacterial interactions. (Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - April 21, 2009 Category: Gastroenterology Authors: Shao Ying WANG, Xiao Ying SHEN, Cai Yun WU, Feng PAN, Yuan Yuan SHEN, Hai Hui SHENG, Xi Mei CHEN, Heng Jun GAO Tags: Original Article Source Type: journals

Effects of non-cytotoxic drugs on the growth of multidrug-resistance human gastric carcinoma cell lineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The combination of non-cytotoxic drug significantly improved the inhibitive effects on the growth of multidrug-resistant human gastric cancer cells. (Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - April 21, 2009 Category: Gastroenterology Authors: Chun Hui WANG, Wen Bin ZHENG, Ou QIANG, Cheng Wei TANG Tags: Original Article Source Type: journals

Bile acids and insulin resistance: implications for treating nonalcoholic fatty liver diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nonalcoholic fatty liver disease is characterized by an accumulation of excess triglycerides in hepatocytes, and insulin resistance is now considered the fundamental operative mechanism throughout the prevalence and progression of the disease. Besides their role in dietary lipid absorption and cholesterol homeostasis, evidence has accumulated that bile acids are also signaling molecules that play two important roles in glucose and lipid metabolism: in the nuclear hormone receptors as farnesoid X receptors (FXR), as well as ligands for G-protein-coupled receptors TGR5. The activated FXR-SHP pathway regulates the enterohepat...
Source: Chinese Journal of Digestive Diseases - April 21, 2009 Category: Gastroenterology Authors: Jue WEI, De Kai QIU, Xiong MA Tags: Review Source Type: journals

An uncommon cause of acute abdomen: Aortic dissection complicated by superior mesenteric artery occlusionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - February 10, 2009 Category: Gastroenterology Authors: Lien-Fu LIN, Jai-Nien TUNG Tags: Case report Source Type: journals

Acute cholangiopancreatic diseases with situs inversus totalis treated with endoscopic sphincterotomy: Report of two casesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - February 10, 2009 Category: Gastroenterology Authors: Bing HU, Chun Hui WANG, Ping CHEN, Cheng Wei TANG Tags: Case report Source Type: journals

Fermented milk containing Bifidobacterium lactis DN-173 010 improved self-reported digestive comfort amongst a general population of adults. A randomized, open-label, controlled, pilot studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: This pilot study shows that daily consumption of a probiotic food in real-life conditions may be useful in improving digestive comfort and symptom experience of adults from general population. Further double-blind randomized controlled studies are required to confirm these health benefits. (Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - February 10, 2009 Category: Gastroenterology Authors: Denis GUYONNET, Alison WOODCOCK, Blandine STEFANI, Cristina TREVISAN, Claire HALL Tags: Other Source Type: journals

Blood concentration of pantoprazole sodium is significantly high in hepatogenic peptic ulcer patients, especially those with a poor CYP2C19 metabolismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: These results suggest that CYP2C19 activity is inversely correlated with the severity of liver disease, especially in PM patients. (Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - February 10, 2009 Category: Gastroenterology Authors: Jian Guo SHAO, Wen JIANG, Ke Qing LI, Jian Rong LU, Yuan Yuan SUN Tags: Other Source Type: journals

Modulation of cytokine gene expression in spleen and Peyer's patches by feeding dahi containing probiotic Lactobacillus casei in miceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: It is concluded that feeding probiotic dahi enhanced the expression of Th1 type cytokines (IFN-[gamma] and IL-2), especially in the mucosal immune organ (Peyer's patches) rather than in systemic organs (the spleen). This indicates that feeding with probiotic dahi may strengthen the host immune system and protect against the progression of various immune-mediated diseases. (Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - February 10, 2009 Category: Gastroenterology Authors: Shalini JAIN, Hariom YADAV, Pushpalata Ravindra SINHA, Francesco MAROTTA Tags: Other Source Type: journals

The efficacy of Combizym in the treatment of Chinese patients with dyspepsia: a multicenter, randomized, placebo-controlled and cross-over studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Combizym treatment effectively ameliorates dyspepsia symptoms in Chinese patients, with satisfactory safety and compliance. (Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - February 10, 2009 Category: Gastroenterology Authors: Zhi Hua RAN, Yao Zong YUAN, Zhao Shen LI, Ji Yao WANG, Chun Hua ZONG, Wei Fen XIE, Ping ZHENG, Sheng Liang CHEN, Xian Bao ZHAN, Shi Yao CHEN, Shu Dong XIAO Tags: Other Source Type: journals

Effects of gut barrier dysfunction and NF-κB activation on aggravating mechanism of severe acute pancreatitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The activation and overexpression of NF-[kappa]B may participate in the aggravating mechanism of SAP. Treatment with PDTC has a protective effect on multiple organs damage in SAP. (Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - February 10, 2009 Category: Gastroenterology Authors: Yi Lin WANG, Yun Jiang ZHENG, Zi Ping ZHANG, Jing Ying SU, Ruo Qing LEI, Yao Qing TANG, Sheng Dao ZHANG Tags: Pancreas Source Type: journals

Clinical epidemiological analysis of the relationship between pancreatic cancer and diabetes mellitus: Data from a single institution in ChinaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Whether diabetes mellitus is a result of or a risk factor for PC is still unclear. The incidence of diabetes mellitus is much higher in the PC patients. The onset of diabetes mellitus in adults might be an alerting factor that could lead to an early diagnosis of pancreatic cancer. (Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - February 10, 2009 Category: Gastroenterology Authors: Tian Tao KUANG, Da Yong JIN, Dan Song WANG, Xue Feng XU, Xiao Ling NI, Wen Chuan WU, Wen Hui LOU Tags: Pancreas Source Type: journals

Early decline of the HCV core antigen can predict SVR in patients with HCV treated by Pegylated interferon plus ribavirin combination therapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: In genotype 1b patients, 500 fmol/L of HCV core antigen level at day 7 was the best predictor for therapeutic response in the early stage of treatment. (Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - February 10, 2009 Category: Gastroenterology Authors: Tatsuya FUJINO, Makoto NAKAMUTA, Yoko AOYAGI, Kunitaka FUKUIZUMI, Ryosuke TAKEMOTO, Tsuyoshi YOSHIMOTO, Toshihiko MIYAHARA, Naohiko HARADA, Hironori SAKAI, Manabu NAKASHIMA, Munechika ENJOJI Tags: Liver Source Type: journals

Demography and clinical course of ulcerative colitis in a multiracial Asian population: A nationwide study from MalaysiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: As in developed countries, most of our patients have a remitting and relapsing pattern of disease but the clinical course appears to be milder, with lower rates of colectomies. There are differences in clinical presentation among the three major ethnic groups, with Indians having a higher prevalence of extra-intestinal manifestations and a trend towards more extensive disease. (Source: Chinese Journal of Digestive Diseases)
Source: Chinese Journal of Digestive Diseases - February 10, 2009 Category: Gastroenterology Authors: I HILMI, R SINGH, S GANESANANTHAN, I YATIM, M RADZI, ABS CHUA, HJ TAN, S HUANG, KS CHIN, J MENON, KL GOH Tags: Colon Source Type: journals