Chinese Journal of Integrative Medicine This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Brazilin Actuates Ferroptosis in Breast Cancer Cells via p53/SLC7A11/GPX4 Signaling Pathway
ConclusionsBrazilin actuated ferroptosis in breast cancer cells, and the underlying mechanism is mainly associated with the p53/SLC7A11/GPX4 signaling pathway. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - April 23, 2024 Category: Internal Medicine Source Type: research

Application of Natural Medicinal Plants Active Ingredients in Oral Squamous Cell Carcinoma
AbstractOral squamous cell carcinoma (OSCC) is the most common malignant cancer of the head and neck, with high morbidity and mortality, ranking as the sixth most common cancer in the world. The treatment of OSCC is mainly radiotherapy, chemotherapy and surgery, however, the prognosis of patients is still poor and the recurrence rate is high. This paper reviews the range of effects of natural medicinal plant active ingredients (NMPAIs) on OSCC cancer, including the types of NMPAIs, anti-cancer mechanisms, involved signaling pathways, and clinical trials. The NMPAIs include terpenoids, phenols, flavonoids, glycosides, alkal...
Source: Chinese Journal of Integrative Medicine - April 12, 2024 Category: Internal Medicine Source Type: research

Naoxueshu Oral Liquid Accelerates Post-Craniotomy Hematoma Absorption in Patients: An Open-Label, Multicenter, and Randomized Controlled Trial
ConclusionsThe administration of NXS demonstrated the potential to promote the percentage reduction in hematoma volume from day 1 to day 15. This intervention was found to be safe and feasible. The response to NXS may be influenced by patient characteristics. (Registration No. ChiCTR1800017981) (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - April 4, 2024 Category: Internal Medicine Source Type: research

Advancements of Macrophages Involvement in Pathological Progression of Colitis-Associated Colorectal Cancer and Associated Pharmacological Interventions
AbstractIntestinal macrophages play crucial roles in both intestinal inflammation and immune homeostasis. They can adopt two distinct phenotypes, primarily determined by environmental cues. These phenotypes encompass the classically activated pro-inflammatory M1 phenotype, as well as the alternatively activated anti-inflammatory M2 phenotype. In regular conditions, intestinal macrophages serve to shield the gut from inflammatory harm. However, when a combination of genetic and environmental elements influences the polarization of these macrophages, it can result in an M1/M2 macrophage activation imbalance, subsequently lea...
Source: Chinese Journal of Integrative Medicine - April 3, 2024 Category: Internal Medicine Source Type: research

Potential Benefits of Green Tea in Prostate Cancer Prevention and Treatment: A Comprehensive Review
AbstractProstate cancer is a prevalent and debilitating disease that necessitates effective prevention and treatment strategies. Green tea, a well-known beverage derived from theCamellia sinensis plant, contains bioactive compounds with potential health benefits, including catechins and polyphenols. This comprehensive review aims to explore the potential benefits of green tea in prostate cancer prevention and treatment by examining existing literature. Green tea possesses antioxidant, anti-inflammatory, and anti-carcinogenic properties attributed to its catechins, particularly epigallocatechin gallate. Epidemiological stud...
Source: Chinese Journal of Integrative Medicine - April 2, 2024 Category: Internal Medicine Source Type: research

Protective Effect of Silibinin on Lipopolysaccharide-Induced Endotoxemia by Inhibiting Caspase-11-Dependent Cell Pyroptosis
ConclusionsSIB can inhibit pyroptosis in the LPS-mediated endotoxemia model, at least in part, by inhibiting the caspase-11-mediated cleavage of GSDMD. Additionally, SIB inhibits the interaction of LPS and caspase-11 and inhibits the LPS-mediated up-regulation of caspase-11 expression, which relieves caspase-11-dependent cell pyroptosis and consequently attenuates LPS-mediated lethality. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - March 27, 2024 Category: Internal Medicine Source Type: research

Electroacupuncture Promotes Angiogenesis in Mice with Cerebral Ischemia by Inhibiting miR-7
ConclusionsEA could promote angiogenesis in MCAO mice likely by inhibiting the expression of miR-7 and relieving inhibition of downstream target genes KLF4/VEGF and ANG-2. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - March 27, 2024 Category: Internal Medicine Source Type: research

Antibacterial Activity of Plants in Cirsium: A Comprehensive Review
AbstractAs ethnic medicine, the whole grass of plants inCirsium was used as antimicrobial. This review focuses on the antimicrobial activity of plants inCirsium, including antimicrobial components, against different types of microbes and bacteriostatic mechanism. The results showed that the main antimicrobial activity components inCirsium plants were flavonoids, triterpenoids and phenolic acids, and the antimicrobial ability varied according to the species and the content of chemicals. Among them, phenolic acids showed a strong antibacterial ability againstAcinetobacter baumannii, Pseudomonas aeruginosa, andEnterococcus fa...
Source: Chinese Journal of Integrative Medicine - March 27, 2024 Category: Internal Medicine Source Type: research

Dynamic Treatment Strategy of Chinese Medicine for Metastatic Colorectal Cancer Based on Machine Learning Algorithm
ConclusionsThe dynamic treatment strategy of CM, based on CSCLSurv for mCRC, plays a certain role in providing clinical hints in CM. It can be further improved in future prospective studies with larger sample sizes. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - March 27, 2024 Category: Internal Medicine Source Type: research

Effects of Aromatherapy on Physical and Mental Health of Cancer Patients Undergoing Radiotherapy and/or Chemotherapy: A Meta-Analysis
ConclusionsAromatherapy is an efficacious, safe and economic adjunctive therapy for cancer patients, which can mend the physical symptoms and mental health of cancer patients. However, more high-quality studies are needed to verify it. (PROSPERO registration No. CRD42023390171) (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - March 15, 2024 Category: Internal Medicine Source Type: research

Immediate Effect of Electro-acupuncture on Endometrial Blood Flow in Patients with Recurrent Implantation Failure: A Randomized Controlled Trial
ConclusionsEA can promptly ameliorate VIMV for the endometrial and right ovary, and endometrial blood flow type. Future randomized controlled trials are warranted to investigate the long-term effects of EA on blood flow of RIF patients and its implications for pregnancy outcomes. (Trial registration No. ChiCTR2200057377) (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - March 4, 2024 Category: Internal Medicine Source Type: research

Tongxinluo Activates PI3K/AKT Signaling Pathway to Inhibit Endothelial Mesenchymal Transition and Attenuate Myocardial Fibrosis after Ischemia-Reperfusion in Mice
ConclusionTXL activated the PI3K/AKT signaling pathway to inhibit EndMT and attenuated myocardial fibrosis after MIRI in mice. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - February 22, 2024 Category: Internal Medicine Source Type: research

Mechanism of Qili Qiangxin Capsule for Heart Failure Based on miR133a-Endoplasmic Reticulum Stress
ConclusionThe pharmacological mechanism of QLQX in improving HF is partly attributed to its regulatory effect on the miR133a-IRE1/XBP1 pathway. (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - February 22, 2024 Category: Internal Medicine Source Type: research

Effect and Safety of Herbal Medicine Foot Baths in Patients with Diabetic Peripheral Neuropathy: A Multicenter Double-Blind Randomized Controlled Trial
ConclusionTreatment of TW foot baths was safe and significantly benefitted patients with DPN. A low dose of TW appeared to be more effective than a high dose. (Registry No. ChiCTR-IOR-16009331). (Source: Chinese Journal of Integrative Medicine)
Source: Chinese Journal of Integrative Medicine - February 20, 2024 Category: Internal Medicine Source Type: research

Effects of NLRP3 Inflammasome Mediated Pyroptosis on Cardiovascular Diseases and Intervention Mechanism of Chinese Medicine
AbstractActivation of the NOD-like receptor protein 3 (NLRP3) inflammasome signaling pathway is an important mechanism underlying myocardial pyroptosis and plays an important role in inflammatory damage to myocardial tissue in patients with cardiovascular diseases (CVDs), such as diabetic cardiomyopathy, ischemia/reperfusion injury, myocardial infarction, heart failure and hypertension. Noncoding RNAs (ncRNAs) are important regulatory factors. Many Chinese medicine (CM) compounds, including their effective components, can regulate pyroptosis and exert myocardium-protecting effects. The mechanisms underlying this protection...
Source: Chinese Journal of Integrative Medicine - February 8, 2024 Category: Internal Medicine Source Type: research