TRIP13 Enhances Radioresistance of Lung Adenocarcinoma Cells 
through the Homologous Recombination Pathway
This study aimed to identify the molecules associated with radioresistance in lung adenocarcinoma (LUAD), identified thyroid hormone receptor interactor 13 (TRIP13) as the main target initially, and explored whether TRIP13 is related to radioresistance in LUAD and the specific mechanism, with the aim of providing theoretical basis and potential targets for the combination therapy of LUAD patients receiving radiotherapy in the clinic. Methods Three datasets, GSE18842, GSE19188 and GSE33532, were selected from the Gene Expression Omnibus (GEO) database and screened for differentially expressed genes (|log FC|>1.5, P (Source:...
Source: Chinese Journal of Lung Cancer - February 1, 2024 Category: Cancer & Oncology Source Type: research

Progress of BRAF Gene Alteration in Non-small Cell Lung Cancer
This article reviewed the progress in structural characteristics, related signaling pathways, mutation types of BRAF gene, and the clinical pathological relationship between BRAF mutations and NSCLC, as well as the therapy, in order to provide more evidences for clinical doctors to make treatment decisions. 
 DOI: 10.3779/j.issn.1009-3419.2024.101.01 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - January 20, 2024 Category: Cancer & Oncology Source Type: research

Research Progress of Granulocytic Myeloid-derived Suppressor Cells 
in Non-small Cell Lung Cancer
This article reviews the immunosuppressive effect of G-MDSCs in non-small cell lung cancer and the progress of related pathway targeting drugs. 
 DOI: 10.3779/j.issn.1009-3419.2023.106.28 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - January 20, 2024 Category: Cancer & Oncology Source Type: research

Establishment of a 21-color Panel for the Detection of Immune Cell Subsets 
in Human Non-small Cell Lung Cancer Tumor Tissues with Flow Cytometry
Conclusion The successfully established 21-color flow cytometry protocol is suitable for the detection of PBMCs and NSCLC tissue samples, which provides an effective new idea for monitoring the immune microenvironment status in lung cancer. 
 DOI: 10.3779/j.issn.1009-3419.2024.102.02 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - January 20, 2024 Category: Cancer & Oncology Source Type: research

Construction of a Prognostic Prediction Model of Patients with Pathologic N0 
in Resected Invasive Mucinous Adenocarcinoma of the Lung
Conclusion The Nomograms based on clinicopathological characteristics in a certain extent, can be used as an effective prognostic tool for patients with pathologic N0 after IMA resection. 
 DOI: 10.3779/j.issn.1009-3419.2024.106.02 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - January 20, 2024 Category: Cancer & Oncology Source Type: research

Establishment of a Predictive Model for Chronic Cough after Pulmonary Resection
Conclusion Chronic cough after pulmonary resection seriously affects the quality of life of patients. The visual presentation form of the Nomogram is helpful to accurately predict chronic cough after pulmonary resection and provide support for clinical decision-making. 
 DOI: 10.3779/j.issn.1009-3419.2024.101.02 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - January 20, 2024 Category: Cancer & Oncology Source Type: research

Identification and Analysis of SND1 as an Oncogene and Prognostic Biomarker 
for Lung Adenocarcinoma
Conclusion SND1 might be an important prognostic biomarker of LUAD and may promote LUAD cells proliferation and migration. 
 DOI: 10.3779/j.issn.1009-3419.2023.102.47 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - January 20, 2024 Category: Cancer & Oncology Source Type: research

Effectiveness Evaluation of Low-dose Spiral Computed Tomography 
for Lung Cancer Screening in Minhang District of Shanghai
This study aimed to evaluate the effectiveness in Chinese adults based on the Lung Cancer Screening Program in Minhang District of Shanghai initiated in 2013. Methods A total of 26,124 subjects aged 40 years or above were enrolled in the Lung Cancer Screening Program during the period of 2013 and 2017. Results of LDCT examination, and screen-detected cancer cases in all participants were obtained from the Reporting System of the Lung Cancer Screening Program. The newly-diagnosed cases and their vital status up to December 31, 2020 were identified through a record linkage with the Shanghai Cancer Registry and the Shanghai V...
Source: Chinese Journal of Lung Cancer - January 20, 2024 Category: Cancer & Oncology Source Type: research

Impact of Folic Acid on the Resistance of Non-small Cell Lung Cancer Cells 
to Osimertinib by Regulating Methylation of DUSP1
This study was conducted to investigate the effect of folic acid (FA) on the resistance of non-small cell lung cancer (NSCLC) cells to Osimertinib (OSM) by regulating the methylation of dual specificity phosphatase 1 (DUSP1). Methods The OSM resistant NSCLC cell line PC9R was establishd by gradually escalation of OSM concentration in PC9 cells. PC9R cells were randomly grouped into Control group, OSM group (5 μmol/L OSM), FA group (600 nmol/L FA), methylation inhibitor decitabine (DAC) group (10 μmol/L DAC), FA+OSM group (600 nmol/L FA+5 μmol/L OSM), and FA+OSM+DAC group (600 nmol/L FA+5 μmol/L OSM+10 μmol/L DAC). CCK...
Source: Chinese Journal of Lung Cancer - January 2, 2024 Category: Cancer & Oncology Source Type: research

A Case of New Rapidly Progressing Ground-glass Nodule Lung Adenocarcinoma Near Primary Lesion after Stereotactic Body Radiation Therapy
We present a successful case of GGN lung cancer treated with SBRT, but a new GGN was found in the lung adjacent to the SBRT target during follow-up. The nodule progressed rapidly and was confirmed as lung adenocarcinoma by surgical resection. No significant risk factors and related driving genes were found in molecular pathological findings and genetic tests. It deserves further study whether new GGN is related to the SBRT. This case suggests that the follow-up after SBRT should be vigilant against the occurrence of new rapidly progressive lung cancer in the target area and adjacent lung tissue. 
 DOI: 10.3779/j.issn.100...
Source: Chinese Journal of Lung Cancer - December 20, 2023 Category: Cancer & Oncology Source Type: research

Relationship between Bacteria in the Lower Respiratory Tract/Lung Cancer 
and the Development of Lung Cancer as well as Its Clinical Application
Due to the advancement of 16S rRNA sequencing technology, the lower respiratory tract microbiota, which was considered non-existent, has been revealed. The correlation between these microorganisms and diseases such as tumor has been a hot topic in recent years. As the bacteria in the surrounding can infiltrate the tumors, researchers have also begun to pay attention to the biological behavior of tumor bacteria and their interaction with tumors. In this review, we present the characteristic of the lower respiratory tract bacteria and summarize recent research findings on the relationship between these microbiota and lung ca...
Source: Chinese Journal of Lung Cancer - December 20, 2023 Category: Cancer & Oncology Source Type: research

Hypothesis of Genetic Diversity Selection in the Occurrence and Development of 
Lung Cancer: Molecular Evolution and Clinical Significance
This article proposed the hypothesis of genetic diversity selection and analyzed its clinical significance. 
 DOI: 10.3779/j.issn.1009-3419.2023.101.34 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - December 20, 2023 Category: Cancer & Oncology Source Type: research

Progress of Immunotherapy in EGFR-mutated Advanced Non-small Cell Lung Cancer
Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are currently the first-line standard of care for patients with non-small cell lung cancer (NSCLC) that harbor EGFR mutations. Nevertheless, resistance to EGFR-TKIs is inevitable. In recent years, although immune checkpoint inhibitors (ICIs) have significantly shifted the treatment paradigm in advanced NSCLC without driver mutation, clinical benefits of these agents are limited in patients with EGFR-mutated NSCLC. Compared with wild-type tumors, tumors with EGFR mutations show more heterogeneity in the expression level of programmed cell death ligand 1...
Source: Chinese Journal of Lung Cancer - December 20, 2023 Category: Cancer & Oncology Source Type: research

Study on the Role and Mechanism of METTL3 Mediating the Up-regulation of 
m6A Modified Long Non-coding RNA THAP7-AS1 in Promoting the Occurrence of 
Lung Cancer
Background and objective Lung cancer is a major threat to human health. The molecular mechanisms related to the occurrence and development of lung cancer are complex and poorly known. Exploring molecular markers related to the development of lung cancer is helpful to improve the effect of early diagnosis and treatment. Long non-coding RNA (lncRNA) THAP7-AS1 is known to be highly expressed in gastric cancer, but has been less studied in other cancers. The aim of the study is to explore the role and mechanism of methyltransferase-like 3 (METTL3) mediated up-regulation of N6-methyladenosine (m6A) modified lncRNA THAP7-AS1 exp...
Source: Chinese Journal of Lung Cancer - December 20, 2023 Category: Cancer & Oncology Source Type: research

Cytology Smears of Rapid On-site Evaluation as Supplemental Material 
for Molecular Testing of Non-small Cell Lung Cancer
Conclusion ROSE smear samples of the thoracic small biopsies are beneficial supplemental materials for ancillary testing of lung cancer. Combined use of cytology smear samples with traditional FFPE section samples can enhance the detection rate of informative mutations in patients with advanced NSCLC. We recommend that the laboratory could further evaluate the ROSE cell smears of the patient when FFPE tissue sections are inadequate, and that adequate cell smears can be used as a supplemental source for the molecular testing of NSCLC. 
 DOI: 10.3779/j.issn.1009-3419.2023.101.35 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - December 20, 2023 Category: Cancer & Oncology Source Type: research