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Addition of cilostazol reduces biological aspirin resistance in aspirin users with ischaemic stroke: a double-blind randomized clinical trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Although this was a negative study, our findings disclosed a trend toward enhanced antiplatelet effects when cilostazol was added to aspirin in ischaemic stroke patients. Combination of aspirin and cilostazol might be a treatment option in the ischaemic stroke patients with AR. (Source: European Journal of Neurology)
Source: European Journal of Neurology - November 17, 2009 Category: Neurology Authors: J.-H. Lee, J.-K. Cha, S. J. Lee, S.-W. Ha, S. U. Kwon Source Type: journals

Aspirin/nicorandil/ticlopidine/cilostazol: Cholestatic-type liver injury treated with ursodeoxycholic acid/plasma exchange and cilostazol-related increase in pulse rate: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - November 16, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Inhibition of metastasis in a murine 4T1 breast cancer model by liposomes preventing tumor cell-platelet interactionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we prepared liposomes containing the platelet aggregation inhibitor Cilostazol (Cil-L). The objective of this study was to investigate the effect of this Cil-L on platelet aggregation and complex formation with murine 4T1 breast cancer cells in vitro and to determine their anti-metastatic potency in a spontaneous metastasis model of 4T1 breast cancer. Cil-L significantly inhibited the aggregation of platelets by up to 78% and completely abolished the complex formation of 4T1 tumor cells in the presence of activated platelets in vitro. Intravenous (i.v.) injection of Cil-L into mice significantly reduced ...
Source: Clinical and Experimental Metastasis - November 14, 2009 Category: Cancer & Oncology Tags: Clinical and Experimental Metastasis Source Type: journals

The Effect of Cilostazol to Arterial Stiffness in the Hypertensive patientEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cilostazol is a potent antiplatelet agent that selectively inhibits phosphodiesterase III, and also it has beneficial effect to peripheral arterial disease, like intermittent claudication, by direct vasodilative action. But the effect of cilostazol on arterial stiffness is unclear. We investigated the effect of cilostazol on arterial stiffness by using Pulse Wave Velocity (PWV) which is most common and non-invasive measure technique. (Source: Artery Research)
Source: Artery Research - November 2, 2009 Category: Cardiology Authors: Jin Oh Na, Chang-Gyu Park, Cheol-Ung Choi, Soon-Yong Suh, Eung-Ju Kim, Seung-Woon Rha, Jin-Won Kim, Hong-Seog Seo, Dong-Joo Oh Tags: Abstracts Source Type: journals

Cilostazol induces metallothionein expression in vascular cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We examined the induction of MT synthesis by cilostazol, an antiplatelet drug, in several vascular component cells to find a new pharmacological effect of cilostazol in vascular system. In human coronary artery endothelial cells, cilostazol significantly increased MT-IX and MT-IIA mRNA levels after the treatment for 6 h and endogenous MT-I/II protein levels after the treatment for 24 and 48 h. In addition, cadmium cytotoxicity was prevented by cilostazol in this endothelial cells. Moreover, cilostazol increased MT-IX and MT-IIA mRNA levels in human coronary artery smooth muscle cells, human brain microvascular endothelial ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - November 1, 2009 Category: Drugs & Pharmacology Authors: Fujiwara Y, Kitagawa T, Shinkai Y, Kaji T, Satoh M Tags: Yakugaku Zasshi Source Type: journals

Prescriber compliance with black box warnings in older adult patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Administrative claims analysis identified low rates of prescriber compliance with BBWs in managing patients age >or=65 years. Claims analysis may be a cost-effective strategy to monitor prescriber compliance with BBWs in older patients at higher risk. PMID: 19895180 [PubMed - in process] (Source: The American Journal of Managed Care)
Source: The American Journal of Managed Care - November 1, 2009 Category: Health Management Authors: Ricci JR, Coulen C, Berger JE, Moore MC, McQueen A, Jan SA Tags: Am J Manag Care Source Type: journals

Stroke Prevention by Cilostazol in Patients with Atherothrombosis: Meta-analysis of Placebo-controlled Randomized TrialsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This first meta-analysis of cilostazol in patients with atherothrombosis demonstrated a significant risk reduction for cerebrovascular events, with no associated increase of bleeding risk. (Source: Journal of Stroke and Cerebrovascular Diseases)
Source: Journal of Stroke and Cerebrovascular Diseases - November 1, 2009 Category: Neurology Authors: Shinichiro Uchiyama, Bart M. Demaerschalk, Shinya Goto, Yukito Shinohara, Fumio Gotoh, William M. Stone, Samuel R. Money, Sun Uck Kwon Tags: Original Articles Source Type: journals

Cilostazol, a specific PDE-3 inhibitor, ameliorates chronic ileitis via suppression of interaction of platelets with monocytes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, a PDE-3 inhibitor ameliorates murine ileitis through attenuating migration of monocytes to the intestinal mucosa, indicating a potential usefulness of anti-platelet drugs for treatment of Crohn's disease. PMID: 19815627 [PubMed - as supplied by publisher] (Source: American Journal of Physiology. Gastrointestinal and Liver Physiology)
Source: American Journal of Physiology. Gastrointestinal and Liver Physiology - October 7, 2009 Category: Physiology Authors: Matsunaga H, Hokari R, Higashiyama M, Kurihara C, Okada Y, Watanabe C, Komoto S, Nakamura M, Kawaguchi A, Nagao S, Miura S Tags: Am J Physiol Gastrointest Liver Physiol Source Type: journals

Cilostazol, a phosphodiesterase inhibitor, attenuates photothrombotic focal ischemic brain injury in hypertensive ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
& Goro Miyakoda (Source: Journal of Cerebral Blood Flow)
Source: Journal of Cerebral Blood Flow - October 6, 2009 Category: Neurology Authors: Hideki ItoAyako HashimotoYutaka MatsumotoHiroshi YaoGoro Miyakoda Source Type: journals

Sirolimus: Stent thrombosis following cilostazol withdrawal in an elderly patient: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - October 6, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

The effects of intravenous cilostazol and nimodipine on cerebral vasospasm after subarachnoid hemorrhage in an experimental rabbit model.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Our results demonstrate that intravenous administration of both cilostazol and nimodipine significantly attenuates cerebral vasospasm after SAH. PMID: 19847758 [PubMed - in process] (Source: Turkish Neurosurgery)
Source: Turkish Neurosurgery - September 30, 2009 Category: Neurosurgery Authors: Bilginer B, Onal MB, Narin F, Soylemezoglu F, Ziyal IM, Ozgen T Tags: Turk Neurosurg Source Type: journals

Long-Term Results of Endovascular Therapy With Nitinol Stent Implantation for TASC II A/B Femoro-Popliteal Artery Lesions.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Nitinol stent implantation for TASC II A/B FPA lesions is suitable and durable in sustaining freedom from restenosis through 4 years of follow-up. PMID: 19724155 [PubMed - as supplied by publisher] (Source: Circulation Journal)
Source: Circulation Journal - September 1, 2009 Category: Cardiology Authors: Iida O, Nanto S, Uematsu M, Ikeoka K, Okamoto S, Dohi T, Fujita M, Nagata S Tags: Circ J Source Type: journals

Comparative effects of cilostazol and aspirin on the impairment of endothelium-dependent cerebral vasodilation caused by acute cigarette smoking in ratsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract We previously reported that acute cigarette smoking can cause a dysfunction of endothelium-dependent vasodilation in cerebral vessels, and that a reduction of oxidative stress by agents such as valsartan, fasudil, or apocynin prevented this impairment. Here, our aim was to investigate the comparative effects of two antiplatelet drugs used for stroke-prevention [a phosphodiesterase-3 inhibitor (cilostazol) and a cyclooxygenase inhibitor (aspirin)] on smoking-induced endothelial dysfunction in cerebral arterioles. In Sprague-Dawley rats, we used a closed cranial window preparation to measure the chang...
Source: Journal of Thrombosis and Thrombolysis - August 11, 2009 Category: Hematology Tags: Journal of Thrombosis and Thrombolysis Source Type: journals

Table of ContentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Lithium Fails to Show Efficacy for Mild Alzheimer's DiseaseStudy Finds Important Differences Between Young and Old Bipolar Manic PatientsMirtazapine-Induced HyponatremiaIncreased Dementia Risk Linked to Long-Term Benzodiazepine UseAcetylcholinesterase Inhibitors Studied in a Real-World SettingEditorial Weighs in on Lithium and Alzheimer'sCombination Cilostazol and Donepezil Treatment for ADAdjunctive Valproate and Pleural EffusionBlack Box Warnings for Bupropion and VareniclineAtomoxetine Safety Labeling Changes (Source: The Brown University Geriatric Psychopharmacology Update)
Source: The Brown University Geriatric Psychopharmacology Update - August 8, 2009 Category: Geriatrics Source Type: journals

Effects of the cAMP-elevating agents cilostamide, cilostazol and forskolin on the phosphorylation of Akt and GSK-3beta in platelets.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Elevating intracellular cAMP has been shown to inhibit platelet function. cAMP interferes with platelet-activating signals which lead to aggregation inhibition, but the precise mechanism is unclear. The present study examined if cAMP-elevating agents inhibited phosphatidylinositol 3-kinase (PI3-kinase) signaling in rat platelets by immunoblotting. Akt is one of the key molecules downstream of PI3K, and is phosphorylated by collagen stimulation. The phosphodiesterase-3 (PDE3) inhibitors cilostamide and cilostazol, and the adenylate cyclase activator forskolin, inhibited collagen-induced Akt phosphorylation at Ser473. Th...
Source: Thrombosis and Haemostasis - August 5, 2009 Category: Hematology Authors: Hayashi H, Sudo T Tags: Thromb Haemost Source Type: journals

Bare-metal stents versus drug-eluting stents in large (>/=3.5mm) single coronary artery: Angiographic and clinical outcomes at 6 months.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The DES and cobalt-chromium BMS placed in large coronary arteries showed equally favorable 6-month clinical outcomes, although the 6-month angiographic results appeared more favorable in the DES group than in the BMS group. PMID: 19632529 [PubMed - in process] (Source: Journal of Cardiology)
Source: Journal of Cardiology - July 29, 2009 Category: Cardiology Authors: Na JO, Kim JW, Choi CU, Choi UJ, Shin SY, Lim HE, Kim EJ, Rha SW, Park CG, Seo HS, Oh DJ Tags: J Cardiol Source Type: journals

Efficacy of Cilostazol After Endovascular Therapy for Femoropopliteal Artery Disease in Patients with Intermittent ClaudicationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In patients with intermittent claudication secondary to femoropopliteal disease, cilostazol reduces restenosis and repeat revascularization after endovascular therapy. (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - July 28, 2009 Category: Surgery Authors: Y. Soga, H. Yokoi, T. Kawasaki Tags: Abstracts Source Type: journals

Cilostazol therapy attenuates monocrotaline-induced pulmonary arterial hypertension in rat modelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pulmonary arterial hypertension (PAH) is characterized by a progressive increase in pulmonary vascular resistance caused by a proliferation of vascular endothelial and smooth muscle cells, resulting in occlusion of the lumen of small pulmonary arteries. Cilostazol, with its antiproliferative effects on vascular endothelial and smooth muscle cells, may ameliorate monocrotaline (MCT)-induced PAH in rats. (Source: Cardiovascular Revascularization Medicine)
Source: Cardiovascular Revascularization Medicine - June 30, 2009 Category: Cardiology Authors: Ali Youssef Moustafa, Li-Teh Chang, Hon-Kan Yip Tags: Special Feature Source Type: journals

Ginkgo biloba extract enhances antiplatelet and antithrombotic effects of cilostazol without prolongation of bleeding timeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we have investigated if GB can potentiate the antiplatelet effects of cilostazol to explore the utility of combination therapy of cilostazol and GB against peripheral occlusive vascular diseases. GB or cilostazol was evaluated alone or in combination for the antiplatelet activity using in vitro and in vivo models. In addition, potential bleeding side effect of the combinative therapy was assessed by measuring bleeding time, prothrombin time (PT) and activated partial thromboplastin time (aPTT) in vivo after oral administration. In in vitro assays using freshly isolated human platelets, the combination of cil...
Source: Thrombosis Research - June 30, 2009 Category: Hematology Authors: Keun Ho Ryu, Hye Young Han, So Young Lee, Sun Duck Jeon, Guang-Jin Im, Bong Yong Lee, Keunyoung Kim, Kyung-Min Lim, Jin-Ho Chung Tags: Brief Communications Source Type: journals

Therapeutic effects of modified Danggui Sini Decoction on plasma level of advanced glycation end products in patients with Wagner grade 0 diabetic foot: a randomized controlled trial.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Modified Danggui Sini Decoction can improve clinical symptoms in patients with diabetic foot ulcers of Wagner grade 0 and it shows therapeutic effects on diabetes complicated with vascular diseases. PMID: 19615315 [PubMed - in process] (Source: Zhong xi yi jie he xue bao : Journal of Chinese Integrative Medicine.)
Source: Zhong xi yi jie he xue bao : Journal of Chinese Integrative Medicine. - June 30, 2009 Category: Complementary Medicine Authors: You WH, Wang P, Li MQ, Zhang Y, Peng YL, Zhang FL Tags: Zhong Xi Yi Jie He Xue Bao Source Type: journals

Silence of the Limbs Pharmacological Symptomatic Treatment of Intermittent Claudication.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Several oral "vasoactive" drugs claim to increase walking capacity in patients with intermittent claudication (IC). Naftidrofuryl, cilostazol, buflomedil, and pentoxifylline are the most studied molecules. Although spanning several decades, several studies underlying these claims were not properly designed, underpowered or showed clinically doubtful outcomes. The evidence for these "vasoactive" drugs has always been received with scepticism, creating the need for systematic reviews and meta-analyses. This brief review discusses the benefit-risk assessment of vasoactive drugs, by applying a systematic review to evaluate...
Source: Current Vascular Pharmacology - June 27, 2009 Category: Drugs & Pharmacology Authors: De Backer T, Stichele RV, De Buyzere M, De Backer G, Van Bortel L Tags: Curr Vasc Pharmacol Source Type: journals

Enhancement of oral bioavailability of cilostazol by forming its inclusion complexes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The study was designed to investigate the effect of cyclodextrins (CDs) on the solubility, dissolution rate, and bioavailability of cilostazol by forming inclusion complexes. Natural CDs like beta-CD, gamma-CD, and the hydrophilic beta-CD derivatives, DM-beta-CD and HP-beta-CD, were used to prepare inclusion complexes with cilostazol. Phase solubility study was carried out and the stability constants were calculated assuming a 1:1 stoichiometry. Solid cilostazol complexes were prepared by coprecipitation and kneading methods and compared with physical mixtures of cilostazol and cyclodextrins. Prepared inclusion complex...
Source: AAPS PharmSciTech - June 27, 2009 Category: Drugs & Pharmacology Authors: Patel SG, Rajput SJ Tags: AAPS PharmSciTech Source Type: journals

ESC 2009: No Significant Reduction in Progression of Symptomatic Intracranial Stenosis With Cilostazol vs ClopidogrelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 16, 2009 Category: Consumer Health News Tags: Neurology & Neurosurgery Source Type: news

Sirolimus and Everolimus Induce Endothelial Cellular Senescence Via Sirtuin 1 Down-Regulation: Therapeutic Implication of Cilostazol After Drug-Eluting Stent ImplantationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Sirolimus and everolimus induce endothelial senescence involving down-regulation of Sirt1. In contrast, the development of endothelial senescence by paclitaxel involves a Sirt1-independent pathway. Because sirolimus and everolimus are involved in Sirt1 modulation, cilostazol rescues HUVEC from sirolimus- or everolimus-induced senescence. These results may have therapeutic implications in the clinical sequelae after DES implantation. (Source: Journal of the American College of Cardiology)
Source: Journal of the American College of Cardiology - June 11, 2009 Category: Cardiology Authors: Hidetaka Ota, Masato Eto, Junya Ako, Sumito Ogawa, Katsuya Iijima, Masahiro Akishita, Yasuyoshi Ouchi Tags: PRE-CLINICAL RESEARCH Source Type: journals

Clinical Trial Summary: Adjunctive Cilostazol Versus High Maintenance Dose Clopidogrel in Patients With Clopidogrel Resistance (ACCEL-RESISTANCE)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Recent studies have demonstrated a high post-treatment platelet activity (HPPR) with clopidogrel as predictive of adverse outcomes after percutaneous coronary intervention (PCI), including stent thrombosis. HPPR can partially be overcome with a higher loading (LD) or maintenance dose (MD) of clopido. . . (Source: Cardiosource)
Source: Cardiosource - June 5, 2009 Category: Cardiology Source Type: organizations

Multifaceted Effects of Selective Inhibitor of Phosphodiesterase III, Cilostazol, for Cerebral Vasospasm after Subarachnoid Hemorrhage in a Dog ModelEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cerebrovasc Dis 2009;28:135-142 (DOI:10.1159/000223439) (Source: Cerebrovascular Diseases)
Source: Cerebrovascular Diseases - June 4, 2009 Category: Neurology Source Type: journals

Cilostazol: Collagenous colitis (first report) in an elderly patient: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - June 2, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Peripheral arterial disease: Pathophysiology, risk factors, diagnosis, treatment, and preventionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Peripheral Artery Disease (PAD) is a strong predictor of MI, stroke and death due to vascular causes. PAD affects 8-12 million people in the United States. As the population lives longer with chronic diseases, researchers estimate that the incidence of PAD will increase, likely increasing myocardial infarction, stroke and death.This paper reviews the epidemiology, pathophysiology, risk factors, treatment and management of PAD. With improved understanding of the disease process, risk factors and treatment, clinicians will be able to detect PAD earlier, provide diagnosis, treat and manage this disease.PAD is associated with ...
Source: Journal of Vascular Nursing - June 1, 2009 Category: Nursing Authors: Rachelle L. Muir Tags: Articles Source Type: journals

Cilostazol protects endothelial cells against lipopolysaccharide-induced apoptosis through ERK1/2- and P38 MAPK-dependent pathways.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Cilostazol protects HUVECs against LPS-induced apoptosis by suppressing mitochondria-dependent apoptotic signaling. Activation of ERK1/2 and p38 MAPKs, and subsequent stimulation of CREB phosphorylation and Bcl-2 expression, may be responsible for the cellular signaling mechanism of cilostazol-mediated protection. PMID: 19543489 [PubMed - in process] (Source: The Korean Journal of Internal Medicine)
Source: The Korean Journal of Internal Medicine - May 31, 2009 Category: Internal Medicine Authors: Lim JH, Woo JS, Shin YW Tags: Korean J Intern Med Source Type: journals

Cilostazol: Collagenous colitis (first report) in an elderly patient: case report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 16 (Source: Reactions Weekly)
Source: Reactions Weekly - May 30, 2009 Category: Drugs & Pharmacology Tags: HTML Source Type: journals

Iloprost- and isoproterenol-induced increases in cAMP are regulated by different phosphodiesterases in erythrocytes of both rabbits and humansEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Activation of the G protein Gs results in increases in cAMP, a necessary step in the pathway for ATP release from rabbit and human erythrocytes. In all cells, the level of cAMP is the product of its synthesis by adenylyl cyclase and its hydrolysis by phosphodiesterases (PDEs). Both iloprost (Ilo), a PGI2 analog, and isoproterenol (Iso), a β-agonist, stimulate receptor-mediated increases in cAMP in rabbit and human erythrocytes. However, the specific PDEs associated with each of these signaling pathways in the erythrocyte have not been fully characterized. Previously, we reported that PDE3B is present in rabbit and hum...
Source: AJP: Heart and Circulatory Physiology - May 1, 2009 Category: Cardiology Authors: Adderley, S. P., Dufaux, E. A., Sridharan, M., Bowles, E. A., Hanson, M. S., Stephenson, A. H., Ellsworth, M. L., Sprague, R. S. Tags: ARTICLES Source Type: journals

Combined Aspirin and Cilostazol Treatment is Associated with Reduced Platelet Aggregation and Prevention of Exercise-Induced Platelet ActivationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Cilostazol has proven efficacy in increasing walking distance in claudicants, but it has not been demonstrated to be more effective than placebo in secondary cardiovascular prevention. The direct effect of exercise on platelet function remains less well defined. We have investigated the effect of combination treatment with aspirin and cilostazol on platelet activity in claudicants subjected to repeated treadmill exercise. (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - April 29, 2009 Category: Surgery Authors: M. Cleanthis, V. Bhattacharya, J. Smout, H. Ashour, G. Stansby Tags: Selected abstracts from the European Journal of Vascular and Endovascular Surgery Source Type: journals

The vascular and biochemical effects of cilostazol in patients with peripheral arterial diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Cilostazol is a well-tolerated, safe, and efficacious treatment for PAD patients. It not only improves patients' symptomatology and quality of life but also appears to have beneficial effects on arterial compliance, possibly through its lipid-lowering property. (Source: Journal of Vascular Surgery)
Source: Journal of Vascular Surgery - April 29, 2009 Category: Surgery Authors: Mark E. O'Donnell, Stephen A. Badger, Mohammed A. Sharif, Ian S. Young, Bernard Lee, Chee V. Soong Tags: Clinical research studies Source Type: journals

Combined Aspirin and Cilostazol Treatment is Associated with Reduced Platelet Aggregation and Prevention of Exercise-Induced Platelet ActivationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Background: Cilostazol has proven efficacy in increasing walking distance in claudicants, but it has not been demonstrated to be more effective than placebo in secondary cardiovascular prevention. The direct effect of exercise on platelet function remains less well defined. We have investigated the effect of combination treatment with aspirin and cilostazol on platelet activity in claudicants subjected to repeated treadmill exercise.Methods: Nineteen claudicants completed a double-blind, randomised, controlled, cross-over trial. Each subject received a 2-week course of aspirin (75mg) and placebo and aspirin and c...
Source: European Journal of Vascular and Endovascular Surgery - April 22, 2009 Category: Surgery Authors: M. Cleanthis, V. Bhattacharya, J. Smout, H. Ashour, G. Stansby Tags: Vascular Medicine Source Type: journals

The Vascular and Biochemical Effects of Cilostazol in Diabetic Patients With Peripheral Arterial DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Cilostazol is a well-tolerated and efficacious treatment, which improves claudication distances in diabetic PAD patients with further benefits in arterial compliance, lipid profiles, and QoL. (Source: Vascular and Endovascular Surgery)
Source: Vascular and Endovascular Surgery - April 21, 2009 Category: Surgery Authors: O'Donnell, M. E., Badger, S. A., Sharif, M. A., Makar, R. R., Young, I. S., Lee, B., Soong, C.V. Tags: Article Source Type: journals

Cilostazol in addition to aspirin and clopidogrel improves long-term outcomes after percutaneous coronary intervention in patients with acute coronary syndromes: a randomized, controlled study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: For patients with acute coronary syndromes, triple-antiplatelet therapy consisting of cilostazol, aspirin, and clopidogrel reduced long-term cardiac and cerebral events after PCI, especially for patients with high-risk profiles. PMID: 19332203 [PubMed - in process] (Source: American Heart Journal)
Source: American Heart Journal - April 1, 2009 Category: Cardiology Authors: Han Y, Li Y, Wang S, Jing Q, Wang Z, Wang D, Shu Q, Tang X Tags: Am Heart J Source Type: journals

Triple Therapy Reduces Restenosis After PCIEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
NEW ORLEANS — Adding cilostazol to a standard, dual-antiplatelet regimen following the placement of either drug-eluting or bare-metal stents led to less restenosis, late loss, and need for revascularization in a meta-analysis of eight small, randomized trials. (Source: Internal Medicine News)
Source: Internal Medicine News - April 1, 2009 Category: Internal Medicine Authors: MITCHEL L. ZOLER Tags: Cardiovascular Medicine Source Type: journals

A combination therapy of donepezil and cilostazol for patients with moderate Alzheimer disease: pilot follow-up study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19307864 [PubMed - in process] (Source: Am J Geriatr Psychia...)
Source: Am J Geriatr Psychia... - March 25, 2009 Category: Geriatrics Authors: Arai H, Takahashi T Tags: Am J Geriatr Psychiatry Source Type: journals

Randomized Comparison of Adjunctive Cilostazol Versus High Maintenance Dose Clopidogrel in Patients With High Post-Treatment Platelet Reactivity: Results of the ACCEL-RESISTANCE (Adjunctive Cilostazol Versus High Maintenance Dose Clopidogrel in Patients With Clopidogrel Resistance) Randomized StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Adjunctive cilostazol reduces the rate of HPPR and intensifies platelet inhibition as compared with a high-MD clopidogrel of 150 mg/day. (Source: Journal of the American College of Cardiology)
Source: Journal of the American College of Cardiology - March 23, 2009 Category: Cardiology Authors: Jeong, Y.-H., Lee, S.-W., Choi, B.-R., Kim, I.-S., Seo, M.-K., Kwak, C. H., Hwang, J.-Y., Park, S.-W. Tags: Interventional Cardiology Source Type: journals

Combined Aspirin and Cilostazol Treatment is Associated with Reduced Platelet Aggregation and Prevention of Exercise-Induced Platelet Activation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Combination treatment with aspirin and cilostazol results in suppression of platelet activation and reduces the effect of exercise on platelets. The benefit seen may be a result of cilostazol enhancing the inhibitory effect of aspirin on the cyclo-oxygenase pathway. PMID: 19297212 [PubMed - as supplied by publisher] (Source: European Journal of Vascular and Endovascular Surgery)
Source: European Journal of Vascular and Endovascular Surgery - March 16, 2009 Category: Surgery Authors: Cleanthis M, Bhattacharya V, Smout J, Ashour H, Stansby G Tags: Eur J Vasc Endovasc Surg Source Type: journals

Effect of Cilostazol Treatment on Adiponectin and Soluble CD40 Ligand Levels in Diabetic Patients With Peripheral Arterial Occlusion Disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Cilostazol can decrease hs-CPR and sCD40L levels and increase that of adiponectin, and then delay the progression of atherogenesis and chronic inflammation in type 2 diabetics, especially those with PAOD. PMID: 19282610 [PubMed - as supplied by publisher] (Source: Circulation Journal)
Source: Circulation Journal - March 12, 2009 Category: Cardiology Authors: Hsieh CJ, Wang PW Tags: Circ J Source Type: journals

Role of cilostazol in alleviating cardiovascular complications induced in experimental rats through regulation of type 1 plasminogen activator inhibitor and transforming growth factor-beta(1) overexpression.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study examined the effect of cilostazol for alleviating CVC through manipulation of transforming growth factor-beta(1) and type 1 plasminogen activator inhibitor as well as their relation to cAMP was also studied. This was achieved in rats through administration of l-NAME (0.1mg/ml) for two weeks, and then followed by i.p. single dose of streptozotocin (65mg/kg). Rats were classified to three groups; normal rats, control diabetic hypertensive rats and the third group were treated with cilostazol (1.8mg daily, orally) for six weeks. Cilostazol improved serum cAMP level and increased plasma NO concentration leading to d...
Source: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - March 12, 2009 Category: Drugs & Pharmacology Authors: Mohamed RH Tags: Biomed Pharmacother Source Type: journals

Cilostazol suppresses neointimal hyperplasia in canine vein graftsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Cilostazol suppressed the development of intimal hyperplasia in canine autogenous vein grafts. Thus, it may be associated with the modulation of cell proliferation and apoptosis. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00595-008-3819-2Authors Fabio A. Kudo, Hokkaido University School of Medicine Department of Cardiovascular Surgery Sapporo, Hokkaido JapanYuka Kondo, Yale University School of Medicine New Department of Vascular Surgery Haven CT USAAkihito Muto, Yale University School of Medicine New Department of Vascular Surgery Haven CT USAKeiko Miyazaki, Hokkaido ...
Source: Surgery Today - February 7, 2009 Category: Surgery Tags: Surgery Today Source Type: journals

Efficacy of Cilostazol After Endovascular Therapy for Femoropopliteal Artery Disease in Patients With Intermittent ClaudicationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Cilostazol reduced restenosis and repeat revascularization after EVT in patients with intermittent claudication due to femoropopliteal disease. (Source: Journal of the American College of Cardiology)
Source: Journal of the American College of Cardiology - December 29, 2008 Category: Cardiology Authors: Soga, Y., Yokoi, H., Kawasaki, T., Nakashima, H., Tsurugida, M., Hikichi, Y., Nobuyoshi, M. Tags: Peripheral Vascular Disease Source Type: journals

The Effects of Cilostazol on Exercise-induced Ischaemia-reperfusion Injury in Patients with Peripheral Arterial Disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Cilostazol significantly improves ACD, in addition to attenuating exercise-induced ischaemia-reperfusion injury, in PAD patients. PMID: 19112032 [PubMed - as supplied by publisher] (Source: European Journal of Vascular and Endovascular Surgery)
Source: European Journal of Vascular and Endovascular Surgery - December 26, 2008 Category: Surgery Authors: O'Donnell ME, Badger SA, Sharif MA, Makar RR, McEneny J, Young IS, Lee B, Soong CV Tags: Eur J Vasc Endovasc Surg Source Type: journals

The Effects of Cilostazol on Peripheral Neuropathy in Diabetic Patients With Peripheral Arterial DiseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Despite extensive animal-based evidence that cilostazol attenuates neuropathic symptomatology, our results do not support this effect in human diabetic PAD patients. (Source: Angiology)
Source: Angiology - December 15, 2008 Category: Cardiology Authors: O'Donnell, M. E., Badger, S. A., Anees Sharif, M., Makar, R. R., Young, I. S., Lee, B., Soong, C. V. Tags: Article Source Type: journals

Safety and Efficacy of Percutaneous Nephrostolithotomy in Patients on Anticoagulant TherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: With careful perioperative regulation of anticoagulation therapy and clotting parameters, percutaneous nephrostolithotomy can be performed safely and efficiently in properly selected patients requiring long-term anticoagulation. (Source: The Journal of Urology)
Source: The Journal of Urology - December 9, 2008 Category: Urology & Nephrology Authors: John C. Kefer, Burak Turna, Robert J. Stein, Mihir M. Desai Tags: Urolithiasis/Endourology Source Type: journals

Aspirin/cilostazol/clopidogrel: Lack of efficacy in preventing stent thrombosis, following placement of sirolimus-eluting stent: case report.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Page: 6 (Source: Reactions Weekly)
Source: Reactions Weekly - December 7, 2008 Category: Drugs & Pharmacology Tags: HTML Source Type: journals

Aspirin/cilostazol/clopidogrel: Lack of efficacy in preventing stent thrombosis, following placement of sirolimus-eluting stent: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - December 7, 2008 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

CILOSTAZOL TABLETStablet [Roxane Laboratories, Inc.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Dec 2, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - December 2, 2008 Category: Drugs & Pharmacology Source Type: organizations