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Postpartum torsades de pointes and long QT syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reports the case of a puerperal patient admitted with diagnosis of urinary tract infection and heart failure. This condition evolved with torsades de pointes ventricular arrhythmias, then, hypokalemia, and use of Ciprofloxacin. Ventricular arrhythmias did not present any improvement after potassium and magnesium replacement, but after implantation of temporary pacemaker, this condition showed signs of improvement. The patient was discharged with QTc at 490 ms, taking Propranolol. (Source: Arquivos Brasileiros de Cardiologia)
Source: Arquivos Brasileiros de Cardiologia - November 20, 2009 Category: Cardiology Source Type: journals

Aradigm Doses First Patient In Long-Term Phase 2 Study Of A Novel Inhaled Ciprofloxacin Formulation For The Management Of Respiratory InfectionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aradigm Corporation (OTCBB:ARDM) (the "Company") announced that the first patient was dosed in a 6-month, multicenter, international Phase 2 clinical trial of a novel version of inhaled ciprofloxacin (ARD-3150) in 40 adult patients with non-cystic fibrosis bronchiectasis. The randomized, double-blind, placebo-controlled trial will be conducted in Australia and New Zealand. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - November 18, 2009 Category: Consumer Health News Tags: Respiratory / Asthma Source Type: news

Aradigm Doses First Patient In Long-Term Phase 2 Study Of A Novel Inhaled Ciprofloxacin Formulation For The Management Of Respiratory InfectionsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aradigm Corporation (OTCBB:ARDM) (the "Company") announced that the first patient was dosed in a 6-month, multicenter, international Phase 2 clinical trial of a novel version of inhaled ciprofloxacin (ARD-3150) in 40 adult patients with non-cystic fibrosis bronchiectasis. The randomized, double-blind, placebo-controlled trial will be conducted in Australia and New Zealand. (Source: Infectious Diseases / Bacteria / Viruses News From Medical News Today)
Source: Infectious Diseases / Bacteria / Viruses News From Medical News Today - November 18, 2009 Category: Infectious Diseases Tags: Respiratory / Asthma Source Type: news

Diagnostic imaging and unforeseen associated lesions in astragalo-scaphoid dislocation: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract A case of an isolated astragalo-scaphoid dislocation following a fall from a motorbike is reported. Due to the diagnostic obscurity of the full extent of the injury, computed tomography (CT) with 3D reconstruction was utilized to precisely visualize the articular condition and revealed the presence of small intra-articular bone fragments and calcaneo-cuboid subluxation. Furthermore, the detailed imaging offered valuable information for preoperative planning. Patient has healed without sequelae. In light of the good outcome in this case, we suggest utilizing CT with 3D reconstruction when there is a ...
Source: Archives of Orthopaedic and Trauma Surgery - November 18, 2009 Category: Orthopaedics Tags: Archives of Orthopaedic and Trauma Surgery Source Type: journals

Acute generalized exanthematous pustulosis (AGEP) induced by cefotaximeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of acute generalized exanthematous pustulosis (AGEP) after cefotaxime use confirmed by a positive patch test. A 30-year-old woman received cefotaxime, fosfomycin and ciprofloxacin for sinusitis. Twelve days after drug initiation, she developed an extending pustular erythema associated with fever. Laboratory investigations showed marked leukocytosis. His blood chemistry was normal. The histological examination showed parakeratosis, spongiosis and nonfollicular intra-epidermal pustules consistent with AGEP. All medications were withdrawn. The symptoms resolved within 11 days after cefotaxime discontinuation....
Source: Fundamental and Clinical Pharmacology - November 18, 2009 Category: Drugs & Pharmacology Authors: Amel Chaabane, Karim Aouam, Lies Gassab, Leila Njim, Naceur A. Boughattas Source Type: journals

Ciprofloxacin/methadone interaction: Torsade de pointes in a methadone-dependent patient: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - November 16, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Fitness Costs and Stability of a High-Level Ciprofloxacin Resistance Phenotype in Salmonella enterica Serotype Enteritidis: Reduced Infectivity Associated with Decreased Expression of SPI-1 Genes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, high-level ciprofloxacin resistance in Salmonella Enteritidis is associated with fitness costs. In the absence of antibiotic selection pressure isolates may acquire mutations enabling reversion to an intermediate-level ciprofloxacin resistance phenotype associated with less significant fitness costs. PMID: 19917752 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)
Source: Antimicrobial Agents and Chemotherapy - November 16, 2009 Category: Microbiology Authors: O'Regan E, Quinn T, Frye JG, Pagès JM, Porwollik S, Fedorka-Cray PJ, McClelland M, Fanning S Tags: Antimicrob Agents Chemother Source Type: journals

Occurrence of organochlorine compounds in Euphausia superba and unhatched eggs of Pygoscelis genus penguins from Admiralty Bay (King George Island, Antarctica) and estimation of biomagnification factors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Polychlorinated biphenyls (PCBs) and organochlorine pesticides are compounds that do not occur naturally in the environment and are not easily degraded by chemical or microbiological action. In the present work, those compounds were analysed in unhatched penguin eggs and whole krill collected in Admiralty Bay, King George Island, Antarctica in the austral summers of 2004-2005 and 2005-2006. The compounds found in higher levels (in a wet weight basis) were, in most of the egg samples, the PCBs (2.53-78.7ngg(-1)), DDTs (2.07-38.0ngg(-1)) and HCB (4.99-39.1ngg(-1)) and after Kruskal-Wallis ANOVA, the occurrence seemed to ...
Source: Chemosphere - November 14, 2009 Category: Chemistry Authors: Cipro CV, Taniguchi S, Montone RC Tags: Chemosphere Source Type: journals

Molecular Epidemiology and Antimicrobial Resistance Mechanisms of Methicillin-Resistant Staphylococcus aureus Isolated from Bovine MilkEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this study was to identify methicillin-resistant Staphylococcus aureus (MRSA) strains gathered from 2002 to 2006 from milk samples in Aydin region in Turkey. Among 93 S. aureus strains isolated from bovine milk with mastitis, 16 were resistant to methicillin. Methicillin-resistant S. aureus strains were studied further for their staphylococcal cassette chromosome mec (SCCmec) types, pulsotypes, spa and MLST types, antimicrobial susceptibilities, mechanisms of resistance and presence of Panton[ndash]Valentine leucocidin (PVL) toxin gene. The MRSA strains were multi-drug resistant. The susceptibility rates to anti...
Source: Zoonoses and Public Health - November 13, 2009 Category: Infectious Diseases Authors: S. Türkyılmaz, S. Tekbıyık, E. Oryasin, B. Bozdogan Source Type: journals

Prevalence and Genetic Relatedness of Antimicrobial-Resistant Escherichia coli Isolated From Animals, Foods and Humans in IcelandEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study gives baseline information on the prevalence of antimicrobial-resistant E. coli from production animals, and their food products in Iceland and the moderate to high resistance rates emphasize the need for continuing surveillance. Further studies on the origin of the resistant strains and the genetic relatedness of strains of different origin are needed. (Source: Zoonoses and Public Health)
Source: Zoonoses and Public Health - November 13, 2009 Category: Infectious Diseases Authors: T. R. Thorsteinsdottir, G. Haraldsson, V. Fridriksdottir, K. G. Kristinsson, E. Gunnarsson Source Type: journals

Enhancement of the Antimalarial Activity of Ciprofloxacin Using a Double Prodrug/Bioorganometallic ApproachEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Journal of Medicinal Chemistry, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Medicinal Chemistry)
Source: Journal of Medicinal Chemistry - November 12, 2009 Category: Chemistry Tags: article Source Type: journals

Inhibitors of RecA Activity Discovered by High-Throughput Screening: Cell-Permeable Small Molecules Attenuate the SOS Response in Escherichia coliEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The phenomenon of antibiotic resistance has created a need for the development of novel antibiotic classes with nonclassical cellular targets. Unfortunately, target-based drug discovery against proteins considered essential for in vitro bacterial viability has yielded few new therapeutic classes of antibiotics. Targeting the large proportion of genes considered nonessential that have yet to be explored by high-throughput screening, for example, RecA, can complement these efforts. Recent evidence suggests that RecA-controlled processes are responsible for tolerance to antibiotic chemotherapy and are involved in pathways tha...
Source: Journal of Biomolecular Screening - November 12, 2009 Category: Molecular Biology Authors: Wigle, T. J., Sexton, J. Z., Gromova, A. V., Hadimani, M. B., Hughes, M. A., Smith, G. R., Yeh, L.-A., Singleton, S. F. Tags: Articles Source Type: journals

The Newer FluoroquinolonesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews fluoroquinolone pharmacology, pharmacodynamic principles, and fluoroquinolone resistance mechanisms, highlighting recent trends in the epidemiology of fluoroquinolone resistance among gram-negative organisms and Streptococcus pneumonia. Important fluoroquinolone safety concerns are discussed, along with indications for the most commonly used fluoroquinolones—ciprofloxacin, levofloxacin, and moxifloxacin. (Source: Infectious Diseases Clinics of North America)
Source: Infectious Diseases Clinics of North America - November 12, 2009 Category: Infectious Diseases Authors: Maureen K. Bolon Source Type: journals

CIPRO (Ciprofloxacin) Solution, Concentrate [Schering Plough Corporation]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Nov 12, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - November 12, 2009 Category: Drugs & Pharmacology Source Type: organizations

Clinical, molecular and epidemiological description of a cluster of community-associated methicillin-resistant Staphylococcus aureus isolates from injecting drug users with bacteraemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clin Microbiol Infect Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is an increasing problem, predominantly in previously healthy individuals including notable risk groups such as the homeless, those who play close-contact sports, military personnel, men who have sex with men (MSM) and injecting drug users (IDUs). Over a 5-month period, four IDUs were admitted to Addenbrooke's Hospital, Cambridge, UK, with MRSA bacteraemia. All four patients presented with complex clinical features, with more than one focus of infection, and were linked epidemiologically. The atypical antibiogram of the MRSA is...
Source: Clinical Microbiology and Infection - November 12, 2009 Category: Microbiology Authors: F. J. Cooke, E. Gkrania-Klotsas, J. C. Howard, M. Stone, A. M. Kearns, M. Ganner, A. J. Carmichael, N. M. Brown Source Type: journals

Occurrence and fate of pharmaceuticals in wastewater treatment plants and rivers in Korea.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We measured 25 pharmaceuticals in ten municipal wastewater treatment plants (WWTPs), one hospital WWTP and five rivers in Korea. In the municipal WWTP influents, acetaminophen, acetylsalicylic acid and caffeine showed relatively high concentrations. The occurrence of pharmaceuticals in the wastewater seems to be influenced by production and consumption of pharmaceuticals. The hospital WWTP influent showed higher total concentrations of pharmaceuticals than the municipal WWTPs, and caffeine, ciprofloxacin and acetaminophen were dominant. In the rivers, caffeine was dominant, and the distribution of pharmaceuticals was r...
Source: Environmental Pollution - November 12, 2009 Category: Environmental Health Authors: Sim WJ, Lee JW, Oh JE Tags: Environ Pollut Source Type: journals

Facile and manifest spectrophotometric methods for the determination of six quinolone antibiotics in pharmaceutical formulations using iron saltsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract Simple spectrophotometric methods have been developed for the determination of six quinolone antibiotics, namely, ciprofloxacin, gatifloxacin, norfloxacin, levofloxacin, ofloxacin, and pefloxacin, in pharmaceutical formulations using three different salts of iron. These methods are based on the formation of complexes with ferric nitrate, ferric chloride, or iron ammonium citrate in which the carboxylic group of quinolones undergoes complexation with iron. The complexes formed in these reactions, having a brown color, were measured at their respective λmax values. The increase in absorbance was dire...
Source: Medicinal Chemistry Research - November 11, 2009 Category: Chemistry Tags: Medicinal Chemistry Research Source Type: journals

A variant of the Southern German clone of methicillin-resistant Staphylococcus aureus is predominant in CroatiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clin Microbiol Infect The aim of the present study was to investigate the antibiotic susceptibility patterns and molecular epidemiology of clinical methicillin-resistant Staphylococcus aureus (MRSA) isolates recovered in 24 hospitals in 20 cities in Croatia from October to December 2004. A total of 1815 consecutive S. aureus isolates were recovered, 248 of which were MRSA. The MRSA isolates were analysed using spa typing, multilocus sequence typing and SCCmec typing. Furthermore, the presence of Panton[ndash]Valentine leukocidin (PVL) genes was determined as a genetic marker for community-associated MRSA. The MRSA prevalen...
Source: Clinical Microbiology and Infection - November 11, 2009 Category: Microbiology Authors: A. Budimir, R. H. Deurenberg, Z. Bo[scaron]njak, E. E. Stobberingh, H. Cetkovic, S. Kalenic Source Type: journals

Restricting ciprofloxacin-induced resistant variant formation in biofilm of Klebsiella pneumoniae B5055 by complementary bacteriophage treatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The combination treatment not only killed the bacteria, but also restricted the formation of resistant variants significantly as compared with individual treatments. Hence, a combination of bacteriophage and ciprofloxacin offers an effective strategy to combat the emergence of treatment-associated resistance. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Verma, V., Harjai, K., Chhibber, S. Tags: Original research Source Type: journals

In vitro activity of nemonoxacin (TG-873870), a novel non-fluorinated quinolone, against clinical isolates of Staphylococcus aureus, enterococci and Streptococcus pneumoniae with various resistance phenotypes in TaiwanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Our findings point to a potentially useful role for nemonoxacin in the treatment of infections caused by MSSA, ciprofloxacin-susceptible MRSA and S. pneumoniae with various resistance phenotypes. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Chen, Y.-H., Liu, C.-Y., Lu, J.-J., King, C.-H. R., Hsueh, P.-R. Tags: Original research Source Type: journals

Toxic epidermal necrolysis and agranulocytosis: Rare adverse effects of ciprofloxacinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Upadya Gatha M, Ruxana KIndian Journal of Medical Sciences 2009 63(10):461-463Ciprofloxacin is one of the most commonly used antibacterial agents with relatively few side effects. Serious adverse reactions reported with ciprofloxacin are rare with an incidence of 0.6%. Recently we came across two rare adverse effects of ciprofloxacin, viz. toxic epidermal necrolysis and agranulocytosis. To our knowledge, a total of seven cases have been reported in the literature documenting an association between oral ciprofloxacin administration and toxic epidermal necrolysis. One case of granulocytopenia, four of pancytopenia and...
Source: Indian Journal of Medical Sciences - November 7, 2009 Category: Journals (General) Authors: Upadya Gatha M, Ruxana K Source Type: journals

Twenty-five year epidemiology of invasive methicillin-resistant Staphylococcus aureus (MRSA) isolates recovered at a burn centerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study we, evaluate the changes in PFT and antimicrobial resistance epidemiology of invasive MRSA isolates over 25 years at a single burn unit. Isolates were tested by pulsed-field gel electrophoresis (PFGE), broth microdilution antimicrobial susceptibility testing, and PCR for the virulence factors Panton–Valentine leukocidin (PVL) and arginine catabolic mobile element (ACME), and the resistance marker staphylococcal chromosomal cassette mec (SCCmec). Forty isolates were screened, revealing stable vancomycin susceptibility MIC without changes over time but decreasing susceptibility to clindamycin and ciprofloxaci...
Source: Burns : Journal of the International Society for Burn Injuries - November 6, 2009 Category: Cosmetic Surgery Authors: Clinton K. Murray, Robert L. Holmes, Michael W. Ellis, Katrin Mende, Steven E. Wolf, Linda K. McDougal, Charles H. Guymon, Duane R. Hospenthal Tags: Articles Source Type: journals

Pouchitis disease activity index (PDAI) does not predict patients with symptoms of pouchitis who will respond to antibioticsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Antibiotic treatment was effective in a considerable number of ulcerative colitis patients whose PDAI score was less than 7 after IPAA. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00595-009-3988-7Authors Mohei Kohyama, Hiroshima General Hospital Department of Surgery 1-3-3 Jigozen, Hatsukaichi Hiroshima 738-8503 JapanYoshio Takesue, Hyogo College of Medicine Department of Infection Control and Prevention Nishinomiya, Hyogo JapanHiroki Ohge, Hiroshima University Department of Surgery, Division of Clinical Medical Science, Graduate School of Biomedical Sciences Hiroshima ...
Source: Surgery Today - November 2, 2009 Category: Surgery Tags: Surgery Today Source Type: journals

Primary care management of otitis media among Australian children.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Acute otitis media (AOM) is diagnosed on the basis of acute onset of pain and fever; a red, bulging tympanic membrane; and middle ear effusion. AOM is managed with analgesia (paracetamol or non-steroidal anti-inflammatory drugs). Antibiotic therapy is minimally effective for most patients; it is most effective for children < 2 years with bilateral otitis media and for children with discharging ears. National guidelines recommend antibiotic therapy for Indigenous children with AOM. Evidence for corticosteroids, topical analgesia and xylitol are scant. Otitis media with effusion (OME) is diagnosed as the presence of m...
Source: Med J Aust - November 2, 2009 Category: Journals (General) Authors: Gunasekera H, O'Connor TE, Vijayasekaran S, Del Mar CB Tags: Med J Aust Source Type: journals

Imported ciprofloxacin-resistant Neisseria meningitidis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19891885 [PubMed - in process] (Source: Emerging Infectious Diseases)
Source: Emerging Infectious Diseases - November 1, 2009 Category: Infectious Diseases Authors: Lapadula G, Viganò F, Fortuna P, Dolara A, Bramati S, Soria A, Foresti S, Gori A Tags: Emerg Infect Dis Source Type: journals

A Survival Case of ABO-Incompatible Liver Transplantation Complicated With Severe Preoperative Infection and Subsequent Overwhelming Postsplenectomy InfectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: A 47-year-old Japanese man was transferred to our hospital because of acute-on-chronic hepatitis B virus infection. On admission, he was suffering from sepsis due to a catheter infection and respiratory failure caused by pulmonary edema and pneumonia, but, as a result of preoperative intensive care, we avoided septic shock. ABO-incompatible liver transplantation (ABO-I-LT) was performed. In accordance with our ABO-I-LT protocol, we administered, rituximab and performed plasma exchange, splenectomy as well as hepatic artery infusion. The patient was discharged 80 days after living donor transplantation (LDLT). How...
Source: Transplantation Proceedings - November 1, 2009 Category: Transplant Surgery Authors: K. Takeda, D. Morioka, T. Kumamoto, K. Matsuo, K. Tanaka, I. Endo, S. Togo, H. Shimada Tags: Case Reports Source Type: journals

African tick bite Fever in a Taiwanese traveler returning from South Africa: molecular and serologic studies.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report the first imported case of African tick bite fever (ATBF) in a patient from Taiwan who returned from a 10-day trip to South Africa. Diagnosis was confirmed by polymerase chain reaction (PCR) from eschar biopsies. Portions of rickettsial ompA (491 bp) and ompB (273 bp) genes were amplified and subsequent sequencing of PCR product showed its 100% identity with R. africae. Microimmunofluorescence (MIF) assay of patient's serum on Days 14 and 46 after the onset of illness revealed IgG seroconversion when tested with spotted fever group (SFG) rickettsiae antigens, including R. africae. The patient clinically improved ...
Source: The American Journal of Tropical Medicine and Hygiene - October 31, 2009 Category: Tropical Medicine Authors: Tsai KH, Lu HY, Huang JH, Fournier PE, Mediannikov O, Raoult D, Shu PY Tags: Am J Trop Med Hyg Source Type: journals

CIPRO (Ciprofloxacin) Tablet, Film Coated [Schering Plough Corporation]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Oct 30, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - October 30, 2009 Category: Drugs & Pharmacology Source Type: organizations

Synthesis, stereochemistry and antimicrobial studies of novel oxime ethers of aza/diazabicycles.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Two series of bicyclic oxime ethers viz, 2,4-diaryl-3-azabicyclo[3.3.1]nonan-9-one O-benzyloximes 13-24 and 2,4,6,8-tetraaryl-3,7-diazabicyclo[3.3.1]nonan-9-one O-benzyloximes 31-36 were synthesized and stereochemistry was established by their spectral (1D and 2D NMR) and crystal studies. Synthesized oxime ethers were screened for their in vitro antimicrobial activity against a set of pathogenic bacteria (Pseudomonas aeruginosa, Staphylococcus aureus, Salmonella typhi, Escherichia coli and Klebsiella pneumoniae) and fungi (Candida albicans, Candida-51, Rhizopus sp., Aspergillus niger and Aspergillus flavus) by twofold ...
Source: Bioorganic & Medicinal Chemistry Letters - October 29, 2009 Category: Chemistry Authors: Parthiban P, Aridoss G, Rathika P, Ramkumar V, Kabilan S Tags: Bioorg Med Chem Lett Source Type: journals

Antibacterial and DNA interaction studies of zinc(II) complexes with quinolone family member, ciprofloxacin.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
DNA binding and cleavage characteristics of Zn(II) complexes have been investigated. The DNA interaction property of the complexes has been investigated using absorption spectra, viscosity measurements, as well as gel electrophoresis studies. Intrinsic binding constant (K(b)) has been estimated under similar set of experimental conditions. Absorption spectral study indicate that the Zn(II) complexes intercalate between the base pairs of the DNA tightly with intrinsic binding constant in the range of 1.0x10(4)-4.0x10(4)M(-1) in phosphate buffer. The proposed DNA binding mode supports the large enhancement in the relativ...
Source: European Journal of Medicinal Chemistry - October 29, 2009 Category: Chemistry Authors: Patel M, Chhasatia M, Parmar P Tags: Eur J Med Chem Source Type: journals

Antibacterial activity of ethanol extract of <i> Andrographis paniculata</i>Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mishra U S, Mishra A, Kumari R, Murthy P N, Naik B SIndian Journal of Pharmaceutical Sciences 2009 71(4):436-438In the present study the ethanol extract of the aerial part of <i>Andrographis paniculata</i> was prepared and evaluated for antimicrobial activity against eleven bacterial strains by determining minimum inhibitory concentration and zone of inhibition. Minimum inhibitory concentration values were compared with control and zone of inhibition values were compared with standard ciprofloxacin in concentration 100 and 200 &#956;g/ml. The results revealed that, the eth...
Source: Indian Journal of Pharmaceutical Sciences - October 28, 2009 Category: Drugs & Pharmacology Authors: Mishra U S, Mishra A, Kumari R, Murthy P N, Naik B S Source Type: journals

Plasmid-mediated QnrS2 determinant in an Aeromonas caviae isolate recovered from a patient with diarrhoeaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clin Microbiol Infect A qnrS2 gene was identified in an Aeromonas caviae isolate (MICs of ciprofloxacin, norfloxacin and ofloxacin >32 mg/L) from a stool sample collected from a patient with gastroenteritis. The analysis of the gyrA and parC genes revealed amino acid substitutions Ser83-Ile and Ser80-Thr, respectively. In addition, five out of 41 nalidixic acid-resistant Aeromonas isolates studied (26 identified as Aeromonas veronii bv sobria and 15 identified as A. caviae) showed ciprofloxacin resistance. The identification of plasmid-mediated qnr genes outside of the Enterobacteriaceae underlines a possible diffusion of ...
Source: Clinical Microbiology and Infection - October 28, 2009 Category: Microbiology Authors: A. Arias, C. Seral, F. Navarro, E. Miró, P. Coll, F. J. Castillo Source Type: journals

Setting Standards For The Prevention And Management Of Travellers' Diarrhoea In Elite Athletes: An Audit Of One Team During The Youth Commonwealth Games In India.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Implementation of strict hygiene guidelines reduced the incidence of TD. Prophylactic ciprofloxacin also reduced the incidence of TD but it is probably not appropriate for use in elite athletes. Rifaximin may be an alternative for this group. PMID: 19858110 [PubMed - as supplied by publisher] (Source: British Journal of Sports Medicine)
Source: British Journal of Sports Medicine - October 25, 2009 Category: Sports Medicine Authors: Tillett EJ, Loosemore M Tags: Br J Sports Med Source Type: journals

CIPRO (Ciprofloxacin) Solution, Concentrate [Schering Plough Corporation]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Oct 20, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - October 20, 2009 Category: Drugs & Pharmacology Source Type: organizations

CIPROFLOXACIN HYDROCHLORIDEtablet [Ivax Pharmaceuticals, Inc.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Oct 20, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - October 20, 2009 Category: Drugs & Pharmacology Source Type: organizations

CIPRO (Ciprofloxacin Hydrochloride) Tablet, Film Coated CIPRO (Ciprofloxacin) Kit [Schering Plough Corporation]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Oct 20, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - October 20, 2009 Category: Drugs & Pharmacology Source Type: organizations

Med Sci Monit 2009; 15(11):CR579-582 "Susceptibility pattern of E. coli-associated urinary tract infection (UTI): A comparison of spinal cord injury-related and nosocomial UTI"Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Despite more risk factors for antibiotic-resistant E. coli in SCI patients, antibiotic-resistant E. coli was observed more in nosocomial UTIs, which may be attributable to the hospital environment. (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 19, 2009 Category: Research Tags: Original article Source Type: journals

Med Sci Monit 2009; 15(11):PI61-65 "Prevalence and antimicrobial susceptibility of Escherichia coli in outpatient urinary isolates in Izmir, Turkey"Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The most important finding of our study is that a considerable proportion of the studied E. coli isolates were resistant to most antibiotics except amikacin. These data provide useful information for clinicians in determining the appropriate empirical antimicrobial regimen, and help authorities to formulate antibiotic prescription policies. (Source: Medical Science Monitor)
Source: Medical Science Monitor - October 19, 2009 Category: Research Tags: Original article Source Type: journals

Polyserositis due to Salmonellaenterica serovar EnteritidisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: Salmonella enterica serovar Enteritidis (S. Enteritidis), a non-typhoid Salmonella, is an important emerging pathogen that usually causes gastroenteritis. Here, we report polyserositis with right-sided pleural effusion and loculated collection of fluid in the peritoneum caused by S. Enteritidis in a 60-year-old man from southern India. The patient was immunocompetent and did not have preceding gastroenteritis or any local structural abnormality. Malnutrition and old age might have been the predisposing factors. The patient received intravenous ceftriaxone for 2 weeks followed by oral ciprofloxacin. Pleurocentesis ...
Source: Transactions of the Royal Society of Tropical Medicine and Hygiene - October 16, 2009 Category: Tropical Medicine Authors: V. Lakshmaiah, M.S. Arun, A. Malini, S.R. Prasad Tags: Case Report Source Type: journals

Summary trends for the Meropenem Yearly Susceptibility Test Information Collection Program: a 10-year experience in the United States (1999–2008)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The Meropenem Yearly Susceptibility Test Information Collection (MYSTIC) Program was a global, longitudinal antimicrobial resistance surveillance network of more than 100 medical centers worldwide monitoring the susceptibility of meropenem and selected other broad-spectrum comparator agents. In 1999, and from 2000 through 2008, a total of 10 or 15 United States (USA) medical centers each forwarded 200 nonduplicate clinical isolates from serious infections to a central processing laboratory. Over the 10-year period of this surveillance program, the activity of meropenem and an average of 11 other antimicrobial age...
Source: Diagnostic Microbiology and Infectious Disease - October 16, 2009 Category: Microbiology Authors: Paul R. Rhomberg, Ronald N. Jones Tags: Antimicrobial Susceptibility Studies Source Type: journals

The synergistic activity of triclosan and ciprofloxacin on biofilms of Salmonella TyphimuriumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Triclosan is a biocide whose wide use has raised a debate about the potential benefits vs. hazards of the incorporation of antimicrobials in consumer products. The purpose of the present study was to determine whether exposure of biofilms of Salmonella enterica serovar Typhimurium to triclosan influences the tolerance of the bacteria towards antibiotics such as ciprofloxacin and vice versa. A synergistic antibiofilm activity was observed when the biofilms were treated with triclosan before or together with ciprofloxacin, and an additive activity was observed with planktonic cells. For example 500 [mu]g mL[minus]1 triclosan...
Source: FEMS Microbiology Letters - October 15, 2009 Category: Microbiology Authors: Mina Tabak, Keren Scher, Michael L. Chikindas, Sima Yaron Source Type: journals

CIPRO (Ciprofloxacin Hydrochloride) Tablet, Film Coated CIPRO (Ciprofloxacin) Kit [Schering Plough Corporation]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Oct 14, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - October 14, 2009 Category: Drugs & Pharmacology Source Type: organizations

Effects of interactions of antibacterial drugs with each other and with 6-mercaptopurine on in vitro growth of Mycobacterium avium subspecies paratuberculosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions This in vitro study suggests that 6-mercaptopurine may be synergistic with macrolides and rifamycin derivatives against MAP. The activity of clarithromycin against MAP seems to be enhanced by rifampicin. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - October 12, 2009 Category: Microbiology Authors: Krishnan, M. Y., Manning, E. J. B., Collins, M. T. Tags: Original research Source Type: journals

Flucloxacillin, still the empirical choice for putative Staphylococcus aureus infections in intensive care units in the NetherlandsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The empirical choice of flucloxacillin in the case of putative S. aureus infections in patients admitted to ICUs in the Netherlands is still justified. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - October 12, 2009 Category: Microbiology Authors: Rijnders, M. I. A., Deurenberg, R. H., Boumans, M. L. L., Hoogkamp-Korstanje, J. A. A., Beisser, P. S., Stobberingh, E. E., on behalf of the Antibiotic Resistance Surveillance Group Tags: Original research Source Type: journals

Decreased linezolid uptake in an in vitro-selected linezolid-resistant Staphylococcus epidermidis mutantEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The mechanism of resistance to linezolid, in this resistant strain, may be related to a decrease in the antimicrobial uptake. This new mechanism of resistance was also related to a little loss of fitness. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - October 12, 2009 Category: Microbiology Authors: Sierra, J. M., Ortega, M., Tarrago, C., Albet, C., Vila, J., Terencio, J., Guglietta, A. Tags: Original research Source Type: journals

Antipseudomonal activity of piperacillin/tazobactam: more than a decade of experience from the SENTRY Antimicrobial Surveillance Program (1997–2007)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, piperacillin/tazobactam remained a very active β-lactam when tested in vitro against clinical isolates of P. aeruginosa found in the SENTRY Program (1997–2007). Trends toward slightly decreased susceptibility were noted in all regions over the last decade (except LA); only polymyxins had susceptibility rates at >90%. Resistance surveillance programs should be sustained to document emerging resistance patterns of old and newer agents for difficult-to-treat pathogens such as P. aeruginosa. (Source: Diagnostic Microbiology and Infectious Disease)
Source: Diagnostic Microbiology and Infectious Disease - October 12, 2009 Category: Microbiology Authors: Ronald N. Jones, Matthew G. Stilwell, Paul R. Rhomberg, Helio S. Sader Tags: Notes Source Type: journals

Conference report: Emergency department doctors rarely adjust antibiotic doses for obese patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: Reuters Health News Area: News According to research reported at the American College of Emergency Physicians annual meeting, emergency department physicians rarely adjust the doses of antibiotics for obese patients. Researchers analysed the rate at which the physicians at an emergency department in the US adhered to dose adjustment guidelines for selected antibiotics established by the university's antibiotic utilisation review (AUR) committee. Over a 3-month period, just over one thousand patients weighing >100kg or with a BMI >40 kg/m2 were prescribed cefazolin (293 doses), cefepime...
Source: NeLM - News - October 11, 2009 Category: Drugs & Pharmacology Source Type: organizations

A randomized double-blind comparison of moxifloxacin and doxycycline/metronidazole/ciprofloxacin in the treatment of acute, uncomplicated pelvic inflammatory diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This multicentre, double-blind study was undertaken to demonstrate non-inferiority of once-daily oral moxifloxacin compared with combination therapy in the management of acute, uncomplicated pelvic inflammatory disease (PID). Women aged ≥18 years with PID were randomized to receive moxifloxacin (400 mg once daily) for 14 days or comparator treatment (doxycycline [100 mg twice daily] plus metronidazole [400 mg three times daily] for 14 days, plus one single 500-mg ciprofloxacin dose). Of the 434 valid per protocol (PP) patients, the overall clinical success rates at 2–14 days post-therapy were 96.6% (moxifloxacin) ...
Source: International Journal of STD and AIDS - October 8, 2009 Category: Global & Universal Authors: Heystek, M, Ross, J D C, for the PID Study Group Tags: Original research articles Source Type: journals

Clinical Management of Rapidly Growing Mycobacterial Cutaneous Infections in Patients after MesotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. This series of rapidly growing mycobacterial cutaneous infections highlights the difficulties in treating such infections and suggests that in vitro susceptibility to antibiotics does not accurately predict their clinical efficacy. (Source: Clinical Infectious Diseases Latest Issue)
Source: Clinical Infectious Diseases Latest Issue - October 8, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals

The effect of sub-inhibitory concentrations of benzalkonium chloride on the competitiveness of Pseudomonas aeruginosa grown in continuous culture.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study investigates the link between adaptation to biocides and antibiotics in Pseudomonas aeruginosa. An enrichment continuous culture of P. aeruginosa NCIMB 10421 (MIC: 25 mg BKC l-1) was operated (D = 0.04 h-1, 792 h) with added benzalkonium chloride (BKC). A derivative, PA-29, (696 h), demonstrated a >12-fold decrease in sensitivity to the biocide (MIC: > 350 mg BKC l-1). The variant demonstrated a 256-fold increase in resistance to ciprofloxacin, with a mutation in the gyrA gene (Thr-83-->Ile). Similarly, culturing of the original strain in a continuous culture system with ciprofloxacin selection pressure...
Source: Microbiology - October 7, 2009 Category: Microbiology Authors: McCay PH, Ocampo-Sosa AA, Fleming GT Tags: Microbiology Source Type: journals