Regulation of Fluid Volume From the Outside: A Role of Glycosaminoglycans in the Skin Interstitium? [Editorial]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - July 12, 2018 Category: Cardiology Authors: Wiig, H. Tags: Heart Failure Editorial Source Type: research

The Luck of Having a Cardiac Implantable Electronic Device [Editorial]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - July 12, 2018 Category: Cardiology Authors: Costanzo, M. R. Tags: Catheter Ablation and Implantable Cardioverter-Defibrillator, Heart Failure Editorial Source Type: research

Dermal Interstitial Alterations in Patients With Heart Failure and Reduced Ejection Fraction: A Potential Contributor to Fluid Accumulation? [Original Articles]
Conclusions: Interstitial glycosaminoglycan concentration is significantly increased in HFrEF patients compared with healthy subjects and correlated with tissue water content and clinical signs of volume overload. A better appreciation of the interstitial compartment might improve management of volume overload in HF. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - July 12, 2018 Category: Cardiology Authors: Nijst, P., Olinevich, M., Hilkens, P., Martens, P., Dupont, M., Tang, W. H. W., Lambrichts, I., Noben, J.-P., Mullens, W. Tags: Pathophysiology, Heart Failure Original Articles Source Type: research

HeartLogic Multisensor Algorithm Identifies Patients During Periods of Significantly Increased Risk of Heart Failure Events: Results From the MultiSENSE Study [Original Articles]
Conclusions: Dynamic assessment using implantable device sensors within HeartLogic by itself or in conjunction with NT-proBNP measurements can identify time-intervals when patients are at significantly increased risk of worsening HF and potentially better triage resources to this vulnerable patient population. Clinical Trial Registration: https://www.clinicaltrials.gov. Unique identifier: NCT01128166. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - July 12, 2018 Category: Cardiology Authors: Gardner, R. S., Singh, J. P., Stancak, B., Nair, D. G., Cao, M., Schulze, C., Thakur, P. H., An, Q., Wehrenberg, S., Hammill, E. F., Zhang, Y., Boehmer, J. P. Tags: Heart Failure, Prognosis Original Articles Source Type: research

Embracing the Long Road to Precision Medicine [Editorial]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - July 11, 2018 Category: Cardiology Authors: Chirinos, J. A., Lanfear, D. E. Tags: Heart Failure Editorial Source Type: research

Data-Driven Approach to Identify Subgroups of Heart Failure With Reduced Ejection Fraction Patients With Different Prognoses and Aldosterone Antagonist Response Patterns [Original Articles]
Conclusions: Using a data-driven approach, we identified heart failure with reduced ejection fraction subgroups with significantly different prognoses and potentially different responses to eplerenone. However, these data should be regarded as hypothesis-generating and prospective validation is warranted, to assess the potential clinical implications of these subgroups. Clinical Trial Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT00232180. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - July 11, 2018 Category: Cardiology Authors: Ferreira, J. P., Duarte, K., McMurray, J. J. V., Pitt, B., van Veldhuisen, D. J., Vincent, J., Ahmad, T., Tromp, J., Rossignol, P., Zannad, F. Tags: Heart Failure Original Articles Source Type: research

Anthracycline Cardiomyopathy: The Plot Gets Thinner [Editorial]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - July 10, 2018 Category: Cardiology Authors: Favreau-Lessard, A. J., Sawyer, D. B., Francis, S. A. Tags: Cardiomyopathy, Heart Failure Editorial Source Type: research

Left Ventricular Mass Change After Anthracycline Chemotherapy [Emerging Investigators]
Conclusions: Early after Anth-bC, LV mass reductions associate with worsening HF symptomatology independent of LVEF. These data suggest an alternative mechanism whereby anthracyclines may contribute to HF symptomatology and raise the possibility that surveillance strategies during Anth-bC should also assess LV mass. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - July 10, 2018 Category: Cardiology Authors: Jordan, J. H., Castellino, S. M., Melendez, G. C., Klepin, H. D., Ellis, L. R., Lamar, Z., Vasu, S., Kitzman, D. W., Ntim, W. O., Brubaker, P. H., Reichek, N., DAgostino, R. B., Hundley, W. G. Tags: Cardiomyopathy, Heart Failure, Remodeling, Magnetic Resonance Imaging (MRI) Emerging Investigators Source Type: research

Cardiac Shock Revealing Systemic Lupus Erythematosus [Images and Case Reports in Heart Failure]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - July 6, 2018 Category: Cardiology Authors: Bouiller, K., Naudion, P., Humbert, S., Gil, H., Meaux-Ruault, N., Cravat, M., Revel, L., Molimard, C., Seronde, M.-F., Magy-Bertrand, N. Tags: Heart Failure, Pericardial Disease Images and Case Reports in Heart Failure Source Type: research

Baseline Characteristics of Patients With Heart Failure and Preserved Ejection Fraction in the PARAGON-HF Trial [Original Articles]
Conclusions: PARAGON-HF represents a contemporary group of patients with HFpEF with similar age and sex distribution compared with prior HFpEF trials but higher prevalence of comorbidities. These findings provide insights into the impact of inclusion criteria on, and regional variation in, HFpEF patient characteristics. CLINICAL TRIAL REGISTRATION: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01920711. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - July 6, 2018 Category: Cardiology Authors: Solomon, S. D., Rizkala, A. R., Lefkowitz, M. P., Shi, V. C., Gong, J., Anavekar, N., Anker, S. D., Arango, J. L., Arenas, J. L., Atar, D., Ben-Gal, T., Boytsov, S. A., Chen, C.-H., Chopra, V. K., Cleland, J., Comin-Colet, J., Duengen, H.-D., Echeverria C Tags: Heart Failure Original Articles Source Type: research

Sarcomeric Auto-Oscillations in Single Myofibrils From the Heart of Patients With Dilated Cardiomyopathy [Original Articles]
Conclusions: Sarcomere dynamics was found to be depressed under loaded conditions in DCM myofibrils because of impairment of thick-thin filament sliding. Thus, microscopic analysis of Ca-SPOC in human cardiac myofibrils is beneficial to systematically unveil the kinetic properties of single sarcomeres in various types of heart disease. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - July 6, 2018 Category: Cardiology Authors: Kagemoto, T., Oyama, K., Yamane, M., Tsukamoto, S., Kobirumaki-Shimozawa, F., Li, A., Dos Remedios, C., Fukuda, N., Ishiwata, S. Tags: Basic Science Research, Contractile Function, Myocardial Biology, Pathophysiology, Heart Failure Original Articles Source Type: research

Unmasking Early Wild-Type Transthyretin Amyloidosis Cardiomyopathy in a Patient With Refractory Atrial Fibrillation and Unremarkable Cardiac Imaging [Images and Case Reports in Heart Failure]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - June 19, 2018 Category: Cardiology Authors: Varedi, D., Kovacsovics, T., Downs Kelly, E., Abraham, J., Cowley, J., Barrell, K., Revelo, M. P., Stehlik, J., Drakos, S., Marrouche, N., Wilson, B., Swanson, E. A., Fang, J., Nativi-Nicolau, J. Tags: Atrial Fibrillation, Cardiomyopathy Images and Case Reports in Heart Failure Source Type: research

Living Without a Pulse: The Vascular Implications of Continuous-Flow Left Ventricular Assist Devices [Advances in Mechanical Circulatory Support]
Pulsatility seems to have a teleological role because evolutionary hierarchy favors higher ordered animals with more complex, multichamber circulatory systems that generate higher pulse pressure compared with lower ordered animals. Yet despite years of such natural selection, the modern generation of continuous-flow left ventricular assist devices (CF-LVADs) that have been increasingly used for the last decade have created a unique physiology characterized by a nonpulsatile, nonlaminar blood flow profile with the absence of the usual large elastic artery Windkessel effect during diastole. Although outcomes and durability h...
Source: Circulation: Heart Failure - June 14, 2018 Category: Cardiology Authors: Purohit, S. N., Cornwell, W. K., Pal, J. D., Lindenfeld, J., Ambardekar, A. V. Tags: Translational Studies, Vascular Biology, Heart Failure, Cardiovascular Surgery, Transplantation Advances in Mechanical Circulatory Support Source Type: research

Predicting the Future of Cardiac Allograft Vasculopathy With Cardiac Positron Emission Tomography: Ready for Prime Time? [Editorial]
(Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - June 11, 2018 Category: Cardiology Authors: DePasquale, E. C. Tags: Imaging, Nuclear Cardiology and PET, Transplantation, Coronary Artery Disease Editorial Source Type: research

Expression and Implication of Clusterin in Left Ventricular Remodeling After Myocardial Infarction [Original Article]
Conclusions: Our results show for the first time that plasma CLU levels are associated with LVR post–myocardial infarction, have in part a cardiac origin, and are a predictor of early death in heart failure patients. (Source: Circulation: Heart Failure)
Source: Circulation: Heart Failure - June 11, 2018 Category: Cardiology Authors: Turkieh, A., Fertin, M., Bouvet, M., Mulder, P., Drobecq, H., Lemesle, G., Lamblin, N., de Groote, P., Porouchani, S., Chwastyniak, M., Beseme, O., Amouyel, P., Mouquet, F., Balligand, J.-L., Richard, V., Bauters, C., Pinet, F. Tags: Animal Models of Human Disease, Biomarkers, Myocardial Biology, Translational Studies, Heart Failure Original Article Source Type: research