Environmental Exposures and Pediatric Cardiology: A Scientific Statement From the American Heart Association
Circulation. 2024 Apr 15. doi: 10.1161/CIR.0000000000001234. Online ahead of print.ABSTRACTEnvironmental toxicants and pollutants are causes of adverse health consequences, including well-established associations between environmental exposures and cardiovascular diseases. Environmental degradation is widely prevalent and has a long latency period between exposure and health outcome, potentially placing a large number of individuals at risk of these health consequences. Emerging evidence suggests that environmental exposures in early life may be key risk factors for cardiovascular conditions across the life span. Children ...
Source: Circulation - April 15, 2024 Category: Cardiology Authors: Justin P Zachariah Pei-Ni Jone Andrew O Agbaje Heather H Ryan Leonardo Trasande Wei Perng Shohreh F Farzan American Heart Association Council on Lifelong Congenital Heart Disease and Heart Health in the Young; Council on Cardiovascular and Stroke Nursing; Source Type: research
Positive Vasoreactivity Testing in Pulmonary Arterial Hypertension: Therapeutic Consequences, Treatment Patterns, and Outcomes in the Modern Management Era
CONCLUSIONS: Our data display heterogeneity within the group of vasoresponders, with a large subset failing to show a sustained satisfactory clinical response to CCBs. This highlights the necessity for comprehensive reassessment during early follow-up. The use of pulmonary artery compliance in addition to current measures may better identify those likely to have a good long-term response.PMID:38606558 | DOI:10.1161/CIRCULATIONAHA.122.063821 (Source: Circulation)
Source: Circulation - April 12, 2024 Category: Cardiology Authors: Felix Gerhardt Eva Fiessler Karen M Olsson Moritz Z Kayser Gabor Kovacs Henning Gall H Ardeschir Ghofrani Roza Badr Eslam Irene M Lang Nicola Benjamin Ekkehard Gr ünig Michael Halank Tobias J Lange Silvia Ulrich Hanno Leuchte Matthias Held Hans Klose Ral Source Type: research
Positive Vasoreactivity Testing in Pulmonary Arterial Hypertension: Therapeutic Consequences, Treatment Patterns, and Outcomes in the Modern Management Era
CONCLUSIONS: Our data display heterogeneity within the group of vasoresponders, with a large subset failing to show a sustained satisfactory clinical response to CCBs. This highlights the necessity for comprehensive reassessment during early follow-up. The use of pulmonary artery compliance in addition to current measures may better identify those likely to have a good long-term response.PMID:38606558 | DOI:10.1161/CIRCULATIONAHA.122.063821 (Source: Circulation)
Source: Circulation - April 12, 2024 Category: Cardiology Authors: Felix Gerhardt Eva Fiessler Karen M Olsson Moritz Z Kayser Gabor Kovacs Henning Gall H Ardeschir Ghofrani Roza Badr Eslam Irene M Lang Nicola Benjamin Ekkehard Gr ünig Michael Halank Tobias J Lange Silvia Ulrich Hanno Leuchte Matthias Held Hans Klose Ral Source Type: research
Positive Vasoreactivity Testing in Pulmonary Arterial Hypertension: Therapeutic Consequences, Treatment Patterns, and Outcomes in the Modern Management Era
CONCLUSIONS: Our data display heterogeneity within the group of vasoresponders, with a large subset failing to show a sustained satisfactory clinical response to CCBs. This highlights the necessity for comprehensive reassessment during early follow-up. The use of pulmonary artery compliance in addition to current measures may better identify those likely to have a good long-term response.PMID:38606558 | DOI:10.1161/CIRCULATIONAHA.122.063821 (Source: Circulation)
Source: Circulation - April 12, 2024 Category: Cardiology Authors: Felix Gerhardt Eva Fiessler Karen M Olsson Moritz Z Kayser Gabor Kovacs Henning Gall H Ardeschir Ghofrani Roza Badr Eslam Irene M Lang Nicola Benjamin Ekkehard Gr ünig Michael Halank Tobias J Lange Silvia Ulrich Hanno Leuchte Matthias Held Hans Klose Ral Source Type: research
Patient-Centered Adult Cardiovascular Care: A Scientific Statement From the American Heart Association
The objective of this scientific statement is to inform health care professionals and stakeholders about the role and impact of patient-centered care in adult cardiovascular medicine. This scientific statement describes the background and rationale for patient-centered care in cardiovascular medicine, provides insight into patient-oriented medication management and patient-reported outcome measures, highlights opportunities and strategies to overcome challenges in patient-centered care, and outlines knowledge gaps and future directions.PMID:38602110 | DOI:10.1161/CIR.0000000000001233 (Source: Circulation)
Source: Circulation - April 11, 2024 Category: Cardiology Authors: Michael J Goldfarb Martha Abshire Saylor Biykem Bozkurt Jillianne Code Katherine E Di Palo Angela Durante Kristin Flanary Ruth Masterson Creber Modele O Ogunniyi Fatima Rodriguez Martha Gulati American Heart Association Council on Clinical Cardiology; Cou Source Type: research
A Prospective Randomized Trial of Direct Oral Anticoagulant Therapy with A Fully Magnetically Levitated LVAD: The DOT-HM3 Study
Circulation. 2024 Apr 9. doi: 10.1161/CIRCULATIONAHA.124.069726. Online ahead of print.NO ABSTRACTPMID:38594972 | DOI:10.1161/CIRCULATIONAHA.124.069726 (Source: Circulation)
Source: Circulation - April 10, 2024 Category: Cardiology Authors: Ivan Netuka Zuzana Tucanova Peter Ivak Stanislav Gregor Dushan Michael Kolesar Tomas Marek Vojtech Melenovsky Jana Binova Zora Dorazilova Marketa Hegarova Martina Podolec Hynek Riha Jean M Connors Mandeep R Mehra Source Type: research
Quality of Life in Patients With Chronic Limb-Threatening Ischemia Treated With Revascularization
CONCLUSIONS: Among patients with chronic limb-threatening ischemia deemed eligible for either Bypass or Endo, revascularization resulted in significant and clinically meaningful improvements in HRQoL. In patients with an available single-segment great saphenous vein for bypass, but not among those without one, Endo was statistically superior on some HRQoL measures; however, these differences were below the threshold of clinically meaningful difference.PMID:38597097 | DOI:10.1161/CIRCULATIONAHA.123.065277 (Source: Circulation)
Source: Circulation - April 10, 2024 Category: Cardiology Authors: Matthew T Menard Alik Farber Richard J Powell Kenneth Rosenfield Michael S Conte Taye H Hamza John A Kaufman Mark J Cziraky Mark A Creager Michael D Dake Michael R Jaff Diane Reid George Sopko Christopher J White Michael B Strong Max van Over Emiliano Chi Source Type: research
A Prospective Randomized Trial of Direct Oral Anticoagulant Therapy with A Fully Magnetically Levitated LVAD: The DOT-HM3 Study
Circulation. 2024 Apr 9. doi: 10.1161/CIRCULATIONAHA.124.069726. Online ahead of print.NO ABSTRACTPMID:38594972 | DOI:10.1161/CIRCULATIONAHA.124.069726 (Source: Circulation)
Source: Circulation - April 10, 2024 Category: Cardiology Authors: Ivan Netuka Zuzana Tucanova Peter Ivak Stanislav Gregor Dushan Michael Kolesar Tomas Marek Vojtech Melenovsky Jana Binova Zora Dorazilova Marketa Hegarova Martina Podolec Hynek Riha Jean M Connors Mandeep R Mehra Source Type: research
Quality of Life in Patients With Chronic Limb-Threatening Ischemia Treated With Revascularization
CONCLUSIONS: Among patients with chronic limb-threatening ischemia deemed eligible for either Bypass or Endo, revascularization resulted in significant and clinically meaningful improvements in HRQoL. In patients with an available single-segment great saphenous vein for bypass, but not among those without one, Endo was statistically superior on some HRQoL measures; however, these differences were below the threshold of clinically meaningful difference.PMID:38597097 | DOI:10.1161/CIRCULATIONAHA.123.065277 (Source: Circulation)
Source: Circulation - April 10, 2024 Category: Cardiology Authors: Matthew T Menard Alik Farber Richard J Powell Kenneth Rosenfield Michael S Conte Taye H Hamza John A Kaufman Mark J Cziraky Mark A Creager Michael D Dake Michael R Jaff Diane Reid George Sopko Christopher J White Michael B Strong Max van Over Emiliano Chi Source Type: research
Asparagine Synthetase Marks a Distinct Dependency Threshold for Cardiomyocyte Dedifferentiation
CONCLUSIONS: We discovered a novel gene Asns as both a molecular marker and an essential mediator, marking a distinct threshold that appears in common for at least 4 models of CMDD, and revealing an Asns/mammalian target of rapamycin complex 1 axis dependency for dedifferentiating cardiomyocytes. Further study will be needed to extrapolate and assess its relevance to other cell state transitions as well as in heart regeneration.PMID:38586957 | DOI:10.1161/CIRCULATIONAHA.123.063965 (Source: Circulation)
Source: Circulation - April 8, 2024 Category: Cardiology Authors: Yike Zhu Matthew Ackers-Johnson Muthu K Shanmugam Leroy Sivappiragasam Pakkiri Chester Lee Drum Yanpu Chen Johnny Kim Wyatt G Paltzer Ahmed I Mahmoud Wilson Lek Wen Tan Mick Chang Jie Lee Jianming Jiang Danh Anh Tuan Luu Shi Ling Ng Peter Yi Qing Li Anhui Source Type: research
Topical Versus Intravenous Tranexamic Acid in Patients Undergoing Cardiac Surgery: The DEPOSITION Randomized Controlled Trial
CONCLUSIONS: Among patients having cardiac surgery, topical administration of tranexamic acid resulted in an 8.3% absolute increase in transfusion without reducing the incidence of seizure, compared to intravenous tranexamic acid.PMID:38587333 | DOI:10.1161/CIRCULATIONAHA.124.069606 (Source: Circulation)
Source: Circulation - April 8, 2024 Category: Cardiology Authors: Andr é Lamy Dmitry A Sirota Frederic Jacques Ahmad Poostizadeh Nicolas Noiseux Sergey Efremov Philippe Demers Boris Akselrod Chew Yin Wang Rakesh C Arora Piotr Branny Shay P McGuinness Craig D Brown Hugues Jeanmart Qiang Zhao Haibo Zhang Emilie P Belley- Source Type: research
Effect of Alcohol-Mediated Renal Denervation on Blood Pressure in the Presence of Antihypertensive Medications: Primary Results from the TARGET BP I Randomized Clinical Trial
CONCLUSIONS: Alcohol-mediated RDN was associated with a modest but statistically significant reduction in 24-hour ambulatory systolic BP compared with sham control. No significant differences between groups in office BP or 6-month major adverse events were observed.PMID:38587557 | DOI:10.1161/CIRCULATIONAHA.124.069291 (Source: Circulation)
Source: Circulation - April 8, 2024 Category: Cardiology Authors: David E Kandzari Michael A Weber Atul Pathak James P Zidar Manish Saxena Shukri W David Roland E Schmieder Adam J Janas Christoph Langer Alexandre Persu Farrell O Mendelsohn Koen Ameloot Malcolm Foster Iii Tim A Fischell Helen Parise Felix Mahfoud Source Type: research
Peripheral Artery Disease: Past and Future
Circulation. 2024 Apr 9;149(15):1151-1153. doi: 10.1161/CIRCULATIONAHA.123.065470. Epub 2024 Apr 8.NO ABSTRACTPMID:38588332 | DOI:10.1161/CIRCULATIONAHA.123.065470 (Source: Circulation)
Source: Circulation - April 8, 2024 Category: Cardiology Authors: Mary M McDermott Source Type: research
Summarizing Primary Results in Clinical Trials With a Time-to-Event End Point: Complementing Different Measures for a Comprehensive Assessment of Treatment Effect
Circulation. 2024 Apr 9;149(15):1154-1156. doi: 10.1161/CIRCULATIONAHA.123.068037. Epub 2024 Apr 8.NO ABSTRACTPMID:38588333 | DOI:10.1161/CIRCULATIONAHA.123.068037 (Source: Circulation)
Source: Circulation - April 8, 2024 Category: Cardiology Authors: Andrea Bellavia Sabina A Murphy Source Type: research
Single-Cell Multimodal Profiling of Atherosclerosis Identifies CD200 as a Cell Surface Lineage Marker of Vascular Smooth Muscle Cells and Their Derived Cells
Circulation. 2024 Apr 9;149(15):1231-1233. doi: 10.1161/CIRCULATIONAHA.123.067092. Epub 2024 Apr 8.NO ABSTRACTPMID:38588334 | PMC:PMC11003722 | DOI:10.1161/CIRCULATIONAHA.123.067092 (Source: Circulation)
Source: Circulation - April 8, 2024 Category: Cardiology Authors: Alexander C Bashore Allen Chung Chinyere Ibikunle Hanying Yan Chenyi Xue Mingyao Li Robert C Bauer Muredach P Reilly Source Type: research
