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552 records returned

Late-Breaking Basic Science Abstracts From the American Heart Association's Scientific Sessions 2009. Late-Breaking Basic Science Oral Abstracts: Translational Studies.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Authors: PMID: 19915179 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - November 13, 2009 Category: Cardiology Tags: Circ Res Source Type: journals

Cardioprotection by CaMKII-{delta}B Is Mediated by Phosphorylation of Heat Shock Factor 1 and Subsequent Expression of Inducible Heat Shock Protein 70.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We conclude that cardiac CaMKII-deltaB and CaMKII-deltaC were inversely regulated in response to oxidative stress and IR injury, and that in contrast to CaMKII-deltaC, CaMKII-deltaB serves as a potent suppressor of cardiomyocyte apoptosis triggered by multiple death-inducing stimuli via phosphorylation of HSF1 and subsequent induction of iHSP70, marking both CaMKII-delta isoforms as promising therapeutic targets for the treatment of ischemic heart disease. PMID: 19910575 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - November 12, 2009 Category: Cardiology Authors: Peng W, Zhang Y, Zheng M, Cheng H, Zhu W, Cao CM, Xiao RP Tags: Circ Res Source Type: journals

The Cellular Prion Protein Identifies Bipotential Cardiomyogenic Progenitors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: PrP(+) cells from beating embryoid bodies (EBs) frequently included nascent Myhc(+) cardiomyocytes. Cultured PrP(+) cells further differentiated, giving rise to cardiac troponin I(+) definitive cardiomyocytes with either an atrial or a ventricular identity. These cells were electrophysiologically functional and able to survive in vivo after transplantation. Combining PrP with a second marker, platelet-derived growth factor receptor (PDGFR)alpha, enabled us to identify an earlier cardiomyogenic population from prebeating EBs, the PrP(+)PDGFRalpha(+) (PRa) cells. The Myhc(-) PRa cells expressed cardiac transcrip...
Source: Circulation Research - November 12, 2009 Category: Cardiology Authors: Hidaka K, Shirai M, Lee JK, Wakayama T, Kodama I, Schneider MD, Morisaki T Tags: Circ Res Source Type: journals

Angiotensin II Type 1 Receptor-Mediated Upregulation of Calcineurin Activity Underlies Impairment of Cardioprotective Signaling in Diabetic Hearts.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results suggest that the diabetic heart is refractory to protection by Jak2-activating ligands because of AT1 receptor-mediated upregulation of calcineurin activity. PMID: 19910577 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - November 12, 2009 Category: Cardiology Authors: Hotta H, Miura T, Miki T, Togashi N, Maeda T, Kim SJ, Tanno M, Yano T, Kuno A, Itoh T, Satoh T, Terashima Y, Ishikawa S, Shimamoto K Tags: Circ Res Source Type: journals

CXCL4 Downregulates the Atheroprotective Hemoglobin Receptor CD163 in Human Macrophages.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: CXCL4 may promote atherogenesis by suppressing CD163 in macrophages, which are then unable to upregulate the atheroprotective enzyme heme oxygenase-1 in response to hemoglobin. PMID: 19910578 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - November 12, 2009 Category: Cardiology Authors: Gleissner CA, Shaked I, Erbel C, Böckler D, Katus HA, Ley K Tags: Circ Res Source Type: journals

Monoamine Oxidase A-Mediated Enhanced Catabolism of Norepinephrine Contributes to Adverse Remodeling and Pump Failure in Hearts With Pressure Overload.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In addition to adrenergic receptor-dependent mechanisms, enhanced MAO-A activity coupled with increased intramyocardial norepinephrine availability results in increased reactive oxygen species generation, contributing to maladaptive remodeling and left ventricular dysfunction in hearts subjected to chronic stress. PMID: 19910579 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - November 12, 2009 Category: Cardiology Authors: Kaludercic N, Takimoto E, Nagayama T, Feng N, Lai EW, Bedja D, Chen K, Gabrielson KL, Blakely RD, Shih JC, Pacak K, Kass DA, Di Lisa F, Paolocci N Tags: Circ Res Source Type: journals

S100B Interaction With the Receptor for Advanced Glycation End Products (RAGE). A Novel Receptor-Mediated Mechanism for Myocyte Apoptosis Postinfarction.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results suggest that interaction of RAGE and its ligand S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53 signaling. This receptor-mediated mechanism is uniquely amenable to therapeutic intervention. PMID: 19910580 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - November 12, 2009 Category: Cardiology Authors: Tsoporis JN, Izhar S, Leong-Poi H, Desjardins JF, Huttunen HJ, Parker TG Tags: Circ Res Source Type: journals

Controlling myocyte cGMP: phosphodiesterase 1 joins the fray.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19893020 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - November 6, 2009 Category: Cardiology Authors: Takimoto E Tags: Circ Res Source Type: journals

Origin of cardiac fibroblasts and the role of periostin.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cardiac fibroblasts are the most populous nonmyocyte cell type within the mature heart and are required for extracellular matrix synthesis and deposition, generation of the cardiac skeleton, and to electrically insulate the atria from the ventricles. Significantly, cardiac fibroblasts have also been shown to play an important role in cardiomyocyte growth and expansion of the ventricular chambers during heart development. Although there are currently no cardiac fibroblast-restricted molecular markers, it is generally envisaged that the majority of the cardiac fibroblasts are derived from the proepicardium via epithelial...
Source: Circulation Research - November 6, 2009 Category: Cardiology Authors: Snider P, Standley KN, Wang J, Azhar M, Doetschman T, Conway SJ Tags: Circ Res Source Type: journals

Mechanisms of Mechanically Induced Spontaneous Arrhythmias in Acute Regional Ischemia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Mechanically induced membrane depolarizations in the ischemic region are the mechanism by which mechanical activity contributes to both the origin of and substrate for spontaneous arrhythmias under the conditions of acute regional ischemia. PMID: 19893011 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - November 5, 2009 Category: Cardiology Authors: Jie X, Gurev V, Trayanova N Tags: Circ Res Source Type: journals

Resident Intimal Dendritic Cells Accumulate Lipid and Contribute to the Initiation of Atherosclerosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Induction of hypercholesterolemia in mice triggers rapid ingestion of lipid by resident intimal DCs, which initiate nascent foam cell lesion formation. PMID: 19893012 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - November 5, 2009 Category: Cardiology Authors: Paulson KE, Zhu SN, Chen M, Nurmohamed S, Jongstra-Bilen J, Cybulsky MI Tags: Circ Res Source Type: journals

Myocyte Enhancer Factor 2 and Class II Histone Deacetylases Control a Gender-Specific Pathway of Cardioprotection Mediated by the Estrogen Receptor.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results reveal a novel gender-specific pathway of cardioprotection mediated by ERalpha and its regulation by MEF2 and class II HDACs. PMID: 19893013 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - November 5, 2009 Category: Cardiology Authors: van Rooij E, Fielitz J, Sutherland LB, Thijssen VL, Crijns HJ, Dimaio MJ, Shelton J, De Windt LJ, Hill JA, Olson EN Tags: Circ Res Source Type: journals

Structural Heterogeneity in the Ventricular Wall Plays a Significant Role in the Initiation of Stretch-Induced Arrhythmias in Perfused Rabbit Right Ventricular Tissues and Whole Heart Preparations.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Global stretches of intermediate strength, rather than intense stretches, created heterogeneous strain (excitation) distributions in the ventricular wall, which can trigger fatal arrhythmias. PMID: 19893014 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - November 5, 2009 Category: Cardiology Authors: Seo K, Inagaki M, Nishimura S, Hidaka I, Sugimachi M, Hisada T, Sugiura S Tags: Circ Res Source Type: journals

MicroRNA-133a Protects Against Myocardial Fibrosis and Modulates Electrical Repolarization Without Affecting Hypertrophy in Pressure-Overloaded Adult Hearts.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results reveal striking differences between in vitro and in vivo phenotypes of miR expression, and further suggest that mRNA signatures do not reliably predict either direct miR targets or major miR effects. PMID: 19893015 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - November 5, 2009 Category: Cardiology Authors: Matkovich SJ, Wang W, Tu Y, Eschenbacher WH, Dorn LE, Condorelli G, Diwan A, Nerbonne JM, Dorn GW Tags: Circ Res Source Type: journals

Extracellular Heat Shock Protein 60, Cardiac Myocytes, and Apoptosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This is the first report of HSP60-induced apoptosis via the TLRs. HSP60-mediated activation of TLR-4 may be a mechanism of myocyte loss in heart failure, where HSP60 has been detected in the plasma. PMID: 19875724 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - October 29, 2009 Category: Cardiology Authors: Kim SC, Stice JP, Chen L, Jung JS, Gupta S, Wang Y, Baumgarten G, Trial J, Knowlton AA Tags: Circ Res Source Type: journals

S100A12 Mediates Aortic Wall Remodeling and Aortic Aneurysm.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: S100A12 expression is sufficient to activate pathogenic pathways through the modulation of oxidative stress, inflammation and vascular remodeling in vivo. PMID: 19875725 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - October 29, 2009 Category: Cardiology Authors: Hofmann Bowman M, Wilk J, Heydemann A, Kim G, Rehman J, Lodato JA, Raman J, McNally EM Tags: Circ Res Source Type: journals

Inpp5f Is a Polyphosphoinositide Phosphatase That Regulates Cardiac Hypertrophic Responsiveness.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results suggest that Inpp5f is a functionally important endogenous modulator of cardiac myocyte size and of the cardiac response to stress. PMID: 19875726 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - October 29, 2009 Category: Cardiology Authors: Zhu W, Trivedi CM, Zhou D, Yuan L, Lu MM, Epstein JA Tags: Circ Res Source Type: journals

Identification of a Novel 14-3-3{zeta} Binding Site Within the Cytoplasmic Domain of Platelet Glycoprotein Ib{alpha} That Plays a Key Role in Regulating the von Willebrand Factor Binding Function of Glycoprotein Ib-IX.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These data suggest a phosphorylation-dependent binding of 14-3-33zeta to central filamin A binding site of GPIbalpha, and the dimeric 14-3-33zeta binding to both the C-terminal site and central RGpSLP site inhibits GPIb-IX association with the membrane skeleton and promotes the VWF binding function of GPIb-IX. PMID: 19875727 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - October 29, 2009 Category: Cardiology Authors: Yuan Y, Zhang W, Yan R, Liao Y, Zhao L, Ruan C, Du X, Dai K Tags: Circ Res Source Type: journals

Contributions of Ion Channel Currents to Ventricular Action Potential Changes and Induction of Early Afterdepolarizations During Acute Hypoxia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: EADs occur predominantly because of the increased sensitivity of ICa-L to beta-AR stimulation during hypoxia. beta-AR stimulation is necessary to induce EADs as EADs are never observed during hypoxia in the absence of beta-AR stimulation. PMID: 19875728 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - October 29, 2009 Category: Cardiology Authors: Gaur N, Rudy Y, Hool L Tags: Circ Res Source Type: journals

Changes in Connexin Expression and the Atrial Fibrillation Substrate in Congestive Heart Failure.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: CHF causes atrial connexin changes, but these are not essential for CHF-related conduction disturbances and AF promotion, which are rather related primarily to fibrotic interruption of muscle bundle continuity. PMID: 19875729 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - October 29, 2009 Category: Cardiology Authors: Burstein B, Comtois P, Michael G, Nishida K, Villeneuve L, Yeh YH, Nattel S Tags: Circ Res Source Type: journals

Matrix metalloproteinase-8 and the regulation of blood pressure, vascular inflammation, and atherosclerotic lesion growth.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19850948 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - October 23, 2009 Category: Cardiology Authors: Mallat Z Tags: Circ Res Source Type: journals

The emerging characterization of lysine residue deacetylation on the modulation of mitochondrial function and cardiovascular biology.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: There is emerging recognition of a novel fuel and redox sensing regulatory program that controls cellular adaptation via nonhistone protein lysine residue acetyl posttranslation modifications. This program functions in tissues with high energy demand and oxidative capacity and is highly enriched in the heart. Deacetylation is regulated by NAD(+)-dependent activation of the sirtuin family of proteins, whereas acetyltransferase modifications are controlled by less clearly delineated acetyltransferases. Subcellular localization specific protein targets of lysine-acetyl modification have been identified in the nu...
Source: Circulation Research - October 23, 2009 Category: Cardiology Authors: Lu Z, Scott I, Webster BR, Sack MN Tags: Circ Res Source Type: journals

Shift to an Involvement of Phosphatidylinositol 3-Kinase in Angiotensin II Actions on Nucleus Tractus Solitarii Neurons of the Spontaneously Hypertensive Rat.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These observations demonstrate that PI3K in the cardiovascular brainstem regions of the SHR may be selectively involved in Ang II-mediated signaling that includes a reduction in baroreceptor reflex function, presumably via a NADPH-ROS mediated pathway. PMID: 19850939 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - October 22, 2009 Category: Cardiology Authors: Sun C, Zubcevic J, Polson JW, Potts JT, Diez-Freire C, Zhang Q, Paton JF, Raizada MK Tags: Circ Res Source Type: journals

Left Ventricular and Myocardial Function in Mice Expressing Constitutively Pseudophosphorylated Cardiac Troponin I.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: A modest increase in PKC-induced cTnI phosphorylation ( approximately 7%) can significantly alter cardiac muscle contraction: negative inotropy via decreased cross-bridge formation and negative lusitropy via persistence of myofilament active state. Based on our data and data from the literature we speculate that effects of PKC-mediated cTnI phosphorylation are site-specific (S43/S45 versus T144). PMID: 19850940 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - October 22, 2009 Category: Cardiology Authors: Kirk JA, Macgowan GA, Evans C, Smith SH, Warren CM, Mamidi R, Chandra M, Stewart AF, Solaro RJ, Shroff SG Tags: Circ Res Source Type: journals

Angiotensin II-Induced Oxidative Stress Resets the Ca2+ Dependence of Ca2+-Calmodulin Protein Kinase II and Promotes a Death Pathway Conserved Across Different Species.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: (1) The Ang II-induced apoptotic cascade converges in both species, in a common pathway mediated by ROS-dependent CaMKII activation which results in p38MAPK activation and apoptosis. (2) In the presence of Ang II or ROS, CaMKII may be activated at subdiastolic Ca(2+) concentrations, suggesting a new mechanism by which ROS reset the Ca(2+) dependence of CaMKII to extremely low Ca(2+) levels. PMID: 19850941 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - October 22, 2009 Category: Cardiology Authors: Palomeque J, Rueda OV, Sapia L, Valverde C, Salas M, Vila Petroff M, Mattiazzi A Tags: Circ Res Source Type: journals

Antioxidant Amelioration of Dilated Cardiomyopathy Caused by Conditional Deletion of NEMO/IKK{gamma} in Cardiomyocytes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results reveal an essential physiological role for NEMO-mediated signaling in the adult heart to maintain cardiac function in response to age-related or mechanical challenges, in part through modulation of oxidative stress. PMID: 19850942 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - October 22, 2009 Category: Cardiology Authors: Kratsios P, Huth M, Temmerman L, Salimova E, Al Banchaabouchi M, Sgoifo A, Manghi M, Suzuki K, Rosenthal N, Mourkioti F Tags: Circ Res Source Type: journals

Blockade of Hsp20 Phosphorylation Exacerbates Cardiac Ischemia/Reperfusion Injury by Suppressed Autophagy and Increased Cell Death.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Collectively, these data indicate that blockade of Ser16-Hsp20 phosphorylation attenuates the cardioprotective effects of Hsp20 against ischemia/reperfusion injury, which may be attributable to suppressed autophagy and increased cell death. Therefore, phosphorylation of Hsp20 at serine 16 may represent a potential therapeutic target in ischemic heart disease. PMID: 19850943 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - October 22, 2009 Category: Cardiology Authors: Qian J, Ren X, Wang X, Zhang P, Jones WK, Molkentin JD, Fan GC, Kranias EG Tags: Circ Res Source Type: journals

Pressure-Mediated Hypertrophy and Mechanical Stretch Induces IL-1 Release and Subsequent IGF-1 Generation to Maintain Compensative Hypertrophy by Affecting Akt and JNK Pathways.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We demonstrate for the first time that pressure-mediated hypertrophy and mechanical stretch generates a subinflammatory low level of IL-1beta, which constitutively causes IGF-1 production to maintain adaptable compensation hypertrophy and inhibit interstitial fibrosis. PMID: 19834007 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - October 14, 2009 Category: Cardiology Authors: Honsho S, Nishikawa S, Amano K, Zen K, Adachi Y, Kishita E, Matsui A, Katsume A, Yamaguchi S, Nishikawa K, Isoda K, Riches DW, Matoba S, Okigaki M, Matsubara H Tags: Circ Res Source Type: journals

Discoidin Domain Receptor 1 on Bone Marrow-Derived Cells Promotes Macrophage Accumulation During Atherogenesis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Taken together, our data support an independent and critical role for Ddr1 in macrophage accumulation at early and late stages of atherogenesis. PMID: 19834008 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - October 14, 2009 Category: Cardiology Authors: Franco C, Britto K, Wong E, Hou G, Zhu SN, Chen M, Cybulsky MI, Bendeck MP Tags: Circ Res Source Type: journals

Defective Phagocytosis of Apoptotic Cells by Macrophages in Atherosclerotic Lesions of ob/ob Mice and Reversal by a Fish Oil Diet.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The findings suggest that in obesity and type 2 diabetes elevated levels of saturated FAs and/or decreased levels of omega-3 FAs contribute to decreased macrophage efferocytosis. Beneficial effects of fish oil diets in atherosclerotic cardiovascular disease may involve improvements in macrophage function related to reversal of defective efferocytosis and could be particularly important in type 2 diabetes and obesity. PMID: 19834009 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - October 14, 2009 Category: Cardiology Authors: Li S, Sun Y, Liang CP, Thorp EB, Han S, Jehle AW, Saraswathi V, Pridgen B, Kanter JE, Li R, Welch CL, Hasty AH, Bornfeldt KE, Breslow JL, Tabas I, Tall AR Tags: Circ Res Source Type: journals

Cardiac metabolic state and Brugada syndrome: a link revealed.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19815826 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - October 8, 2009 Category: Cardiology Authors: Chahine M Tags: Circ Res Source Type: journals

Human studies of angiogenic gene therapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Despite significant advances in medical, interventional, and surgical therapy for coronary and peripheral arterial disease, the burden of these illnesses remains high. To address this unmet need, the science of therapeutic angiogenesis has been evolving for almost two decades. Early preclinical studies and phase I clinical trials achieved promising results with growth factors administered as recombinant proteins or as single-agent gene therapies, and data accumulated through 10 years of clinical trials indicate that gene therapy has an acceptable safety profile. However, more rigorous phase II and phase III clinical tr...
Source: Circulation Research - October 8, 2009 Category: Cardiology Authors: Gupta R, Tongers J, Losordo DW Tags: Circ Res Source Type: journals

Progenitor Cells From the Explanted Heart Generate Immunocompatible Myocardium Within the Transplanted Donor Heart.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our data suggest that tissue regeneration by differentiation of recipient cardiac progenitor cells restored a significant portion of the rejected donor myocardium. Ultimately, immunosuppressive therapy may be only partially required improving quality of life and lifespan of patients with cardiac transplantation. PMID: 19815820 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - October 7, 2009 Category: Cardiology Authors: D'Alessandro DA, Kajstura J, Hosoda T, Gatti A, Bello R, Mosna F, Bardelli S, Zheng H, D'Amario D, Padin-Iruegas ME, Carvalho AB, Rota M, Zembala MO, Stern D, Rimoldi O, Urbanek K, Michler RE, Leri A, Anversa P Tags: Circ Res Source Type: journals

Metabolic Remodeling Induced by Mitochondrial Aldehyde Stress Stimulates Tolerance to Oxidative Stress in the Heart.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The findings of the present study indicate that mitochondrial aldehyde stress in the heart induces metabolic remodeling, leading to activation of the glutathione-redox cycle, which confers resistance against acute oxidative stress induced by ischemia/reperfusion. PMID: 19815821 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - October 7, 2009 Category: Cardiology Authors: Endo J, Sano M, Katayama T, Hishiki T, Shinmura K, Morizane S, Matsuhashi T, Katsumata Y, Zhang Y, Ito H, Nagahata Y, Marchitti S, Nishimaki K, Wolf AM, Nakanishi H, Hattori F, Vasiliou V, Adachi T, Ohsawa I, Taguchi R, Hirabayashi Y, Ohta S, Suematsu M, Tags: Circ Res Source Type: journals

ASK1 Regulates Cardiomyocyte Death but Not Hypertrophy in Transgenic Mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results indicate that ASK1 does not directly regulate the cardiac hypertrophic response in vivo, but it does alter cell death and propensity to cardiomyopathy, in part, through a calcineurin-dependent mechanism. PMID: 19815822 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - October 7, 2009 Category: Cardiology Authors: Liu Q, Sargent MA, York AJ, Molkentin JD Tags: Circ Res Source Type: journals

Conditional Ablation of Nonmuscle Myosin II-B Delineates Heart Defects in Adult Mice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: By avoiding the embryonic lethality found in germline-ablated mice, we were able to study the function of NMII-B in adult mice and show that absence of NMII-B in cardiac myocytes results in cardiomyopathy in the adult heart. We also define a role for NMII-B in maintaining the integrity of intercalated discs. PMID: 19815823 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - October 7, 2009 Category: Cardiology Authors: Ma X, Takeda K, Singh A, Yu ZX, Zerfas P, Blount A, Liu C, Towbin JA, Schneider MD, Adelstein RS, Wei Q Tags: Circ Res Source Type: journals

Complement-Dependent Inflammation and Injury in a Murine Model of Brain Dead Donor Hearts.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These data indicate an important role for complement in BD-induced inflammation and injury and suggest that a complement inhibitory strategy applied to the donor (in addition to the recipient) may provide graft protection. PMID: 19815824 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - October 7, 2009 Category: Cardiology Authors: Atkinson C, Varela JC, Tomlinson S Tags: Circ Res Source Type: journals

Spiral Waves and Reentry Dynamics in an In Vitro Model of the Healed Infarct Border Zone.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Cocultures reproduce several architectural and electrophysiological features of the healed IBZ. Reentry termination by L-type Ca(2+) channel, but not Na(+) channel, blockers suggests a greater Ca(2+)-dependence of propagation. These results may help explain the low efficacy of pure Na(+) channel blockers in preventing and terminating clinical VTs late after MI. PMID: 19815825 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - October 7, 2009 Category: Cardiology Authors: Chang MG, Zhang Y, Chang CY, Xu L, Emokpae R, Tung L, Marbán E, Abraham MR Tags: Circ Res Source Type: journals

Smooth Muscle Cell {alpha}2{delta}-1 Subunits Are Essential for Vasoregulation by CaV1.2 Channels.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: alpha2delta-1 is essential for plasma membrane expression of arterial myocyte CaV1.2 alpha1 subunits. alpha2delta-1 targeting can block CaV1.2 channels directly and inhibit surface expression of CaV1.2 alpha1 subunits, leading to vasodilation. These data identify alpha2delta-1 as a novel molecular target in arterial myocytes, the manipulation of which regulates contractility. PMID: 19797702 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - September 30, 2009 Category: Cardiology Authors: Bannister JP, Adebiyi A, Zhao G, Narayanan D, Thomas CM, Feng JY, Jaggar JH Tags: Circ Res Source Type: journals

Gene Therapy With the Angiogenic Cytokine Secretoneurin Induces Therapeutic Angiogenesis by a Nitric Oxide-Dependent Mechanism.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In summary, our data indicate that gene therapy with secretoneurin induces therapeutic angiogenesis, arteriogenesis, and vasculogenesis in the hindlimb ischemia model by a nitric oxide-dependent mechanism. PMID: 19797703 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - September 30, 2009 Category: Cardiology Authors: Schgoer W, Theurl M, Jeschke J, Beer AG, Albrecht K, Gander R, Rong S, Vasiljevic D, Egger M, Wolf AM, Frauscher S, Koller B, Tancevski I, Patsch JR, Schratzberger P, Piza-Katzer H, Ritsch A, Bahlmann FH, Fischer-Colbrie R, Wolf D, Kirchmair R Tags: Circ Res Source Type: journals

Molecular Identification and Functional Characterization of a Mitochondrial Sulfonylurea Receptor 2 Splice Variant Generated by Intraexonic Splicing.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We identify a novel SUR2 IES variant in cardiac mitochondria and provide evidence that the variant-based channel can form an ATP-sensitive conductance and may contribute to cardioprotection. PMID: 19797704 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - September 30, 2009 Category: Cardiology Authors: Ye B, Kroboth S, Pu JL, Sims J, Aggarwal N, McNally E, Makielski J, Shi NQ Tags: Circ Res Source Type: journals

Titin phosphorylation: myocardial passive stiffness regulated by the intracellular giant.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19797191 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - September 24, 2009 Category: Cardiology Authors: Ahmed SH, Lindsey ML Tags: Circ Res Source Type: journals

Plugging vascular leak by sphingosine kinase from bone marrow progenitor cells.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19797192 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - September 24, 2009 Category: Cardiology Authors: Hla T Tags: Circ Res Source Type: journals

On the road to iPS cell cardiovascular applications.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19797193 [PubMed - in process] (Source: Circulation Research)
Source: Circulation Research - September 24, 2009 Category: Cardiology Authors: Kamp TJ, Lyons GE Tags: Circ Res Source Type: journals

Specification of the cardiac conduction system by transcription factors.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Diseases of the cardiovascular system that cause sudden cardiac deaths are often caused by lethal arrhythmias that originate from defects in the cardiac conduction system. Development of the cardiac conduction system is a complex biological process that can be wrought with problems. Although several genes involved in mature conduction system function have been identified, their association with development of specific subcomponents of the cardiac conduction system remains challenging. Several transcription factors, including homeodomain proteins and T-box proteins, are essential for cardiac conduction system morphogene...
Source: Circulation Research - September 24, 2009 Category: Cardiology Authors: Hatcher CJ, Basson CT Tags: Circ Res Source Type: journals

Whole Body UVA Irradiation Lowers Systemic Blood Pressure by Release of Nitric Oxide From Intracutaneous Photolabile Nitric Oxide Derivates.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: UVA irradiation of human skin caused a significant drop in blood pressure even at moderate UVA doses. The effects were attributed to UVA induced release of NO from cutaneous photolabile NO derivates. PMID: 19797169 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - September 23, 2009 Category: Cardiology Authors: Opländer C, Volkmar CM, Paunel-Görgülü A, van Faassen EE, Heiss C, Kelm M, Halmer D, Mürtz M, Pallua N, Suschek CV Tags: Circ Res Source Type: journals

TRPC1 Channels Are Critical for Hypertrophic Signaling in the Heart.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: From these studies, we suggest that TRPC1 channels are critical for the adaptation to biomechanical stress and TRPC dysregulation leads to maladaptive cardiac hypertrophy and failure. PMID: 19797170 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - September 23, 2009 Category: Cardiology Authors: Seth M, Zhang ZS, Mao L, Graham V, Burch J, Stiber J, Tsiokas L, Winn M, Abramowitz J, Rockman HA, Birnbaumer L, Rosenberg P Tags: Circ Res Source Type: journals

Deletion of Protein Tyrosine Phosphatase 1b Improves Peripheral Insulin Resistance and Vascular Function in Obese, Leptin-Resistant Mice via Reduced Oxidant Tone.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Deletion of PTP1B improved both endothelium dependent and independent NO-mediated dilation and reduced superoxide generation in db/db mice. PTP1B deletion did not affect any vascular function in lean mice. Taken together, these data reveal a role for peripheral insulin resistance as the mediator of vascular dysfunction in obesity. PMID: 19797171 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - September 23, 2009 Category: Cardiology Authors: Ali MI, Ketsawatsomkron P, Belin de Chantelemele EJ, Mintz JD, Muta K, Salet C, Black SM, Tremblay ML, Fulton DJ, Marrero MB, Stepp DW Tags: Circ Res Source Type: journals

Differential Healing After Sirolimus, Paclitaxel, and Bare Metal Stent Placement in Combination With Peroxisome Proliferator-Activator Receptor {gamma} Agonists. Requirement for mTOR/Akt2 in PPAR{gamma} Activation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: mTOR/Akt2 is required for optimal PPARgamma activation. Patients who receive SESs during concomitant RSG treatment may be at risk for delayed stent healing. PMID: 19797172 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - September 23, 2009 Category: Cardiology Authors: Finn AV, John M, Nakazawa G, Polavarapu R, Karmali V, Xu X, Cheng Q, Davis T, Raghunathan C, Acampado E, Ezell T, Lajoie S, Eppihimer M, Kolodgie FD, Virmani R, Gold HK Tags: Circ Res Source Type: journals

Dystroglycan Matrix Receptor Function in Cardiac Myocytes Is Important for Limiting Activity-Induced Myocardial Damage.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our findings suggest dystroglycan function as an extracellular matrix receptor in cardiac myocytes plays a primary role in limiting myocardial damage from spreading to neighboring cardiac myocytes, and loss of dystroglycan matrix receptor function in cardiac muscle cells is likely important in the development of cardiomyopathy in glycosylation-deficient muscular dystrophies. PMID: 19797173 [PubMed - as supplied by publisher] (Source: Circulation Research)
Source: Circulation Research - September 23, 2009 Category: Cardiology Authors: Michele DE, Kabaeva Z, Davis SL, Weiss RM, Campbell KP Tags: Circ Res Source Type: journals