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Nontuberculous mycobacterial pulmonary infection in renal transplant recipientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report on a Mycobacterium avium complex pulmonary infection in a KTR with underlying chronic obstructive pulmonary disease. Chest computed tomography showed an excavated lesion of the right upper lobe, similar to a typical lesion of pulmonary tuberculosis. Evolution was favorable with multiple-drug therapy including rifampicin, ethambutol, and clarithromycin, along with a slight reduction in immunosuppression. We review the literature and discuss the epidemiology, diagnosis, management, and follow-up of this uncommon post-transplant complication. (Source: Transplant Infectious Disease)
Source: Transplant Infectious Disease - November 20, 2009 Category: Transplant Surgery Authors: T.A. Ho, M. Rommelaere, E. Coche, J.-C. Yombi, N. Kanaan Source Type: journals

Borderline CD30+ cutaneous lymphoproliferative disorder: report of a case with expression of cytotoxic markers and response to clarithromycinEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a case of borderline CD30+ CLPD with cytotoxic phenotype, presenting in a 22-year-old male patient as an ulcer on the forearm. He reported having had similar ulcers on the buttock and thigh that spontaneously regressed over the course of 1 year. The lesion resolved with a single course of clarithromycin; a subsequent lesion, too, responded to clarithromycin, and no recurrences or systemic involvement have been documented in the 9-month follow-up. A conservative approach in the management of CD30+ CLPD is recommended. We believe that the anti-inflammatory and apoptotic effects of clarithromycin on T cells may ha...
Source: Journal of Cutaneous Pathology - November 18, 2009 Category: Pathology Authors: Pedro Ponte, Vasco Serrão, Isabel Viana, Esmeralda Vale, Alexandre João, Lorenzo Cerroni Source Type: journals

Clarithromycin/colchicine interaction: Rhabdomyolysis: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - November 16, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Revival and emended description of 'Mycobacterium paraffinicum' (Davis, Chase and Raymond 1956) as Mycobacterium paraffinicum (ex Davis, Chase and Raymond 1956) sp. nov., nom. rev.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The omission of the name 'Mycobacterium paraffinicum' from the 1980 Approved List of Bacterial Names was due to phenotypic confusion surrounding a close relationship with Mycobacterium scrofulaceum. Correspondingly 'M. paraffinicum' strains grew slowly in >7 days, stained acid-alcohol fast, produced yellow-pigmented smooth waxy colonies in the dark at an optimal temperature of 35 degrees C. However 'M. paraffinicum' strains demonstrated no activity for urease, nicotinamidase or pyrazinamidase, and lacked growth at 42 degrees C as compared to M. scrofulaceum. The mycolic acid pattern as determined by high performance...
Source: International Journal of Systematic and Evolutionary Microbiology - November 13, 2009 Category: Microbiology Authors: Toney NC, Adekambi T, Toney S, Yakrus M, Butler WR Tags: Int J Syst Evol Microbiol Source Type: journals

Macrolides, Ketolides, and Glycylcyclines: Azithromycin, Clarithromycin, Telithromycin, TigecyclineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The advanced macrolides, azithromycin and clarithromycin, and the ketolide, telithromycin, are structural analogs of erythromycin. They have several distinct advantages when compared with erythromycin, including enhanced spectrum of activity, more favorable pharmacokinetics and pharmacodynamics, once-daily administration, and improved tolerability. Clarithromycin and azithromycin are used extensively for the treatment of respiratory tract infections, sexually transmitted diseases, and Helicobacter pylori–associated peptic ulcer disease. Telithromycin is approved for the treatment of community-acquired pneumonia. Severe h...
Source: Infectious Diseases Clinics of North America - November 12, 2009 Category: Infectious Diseases Authors: Jerry M. Zuckerman, Fozia Qamar, Bartholomew R. Bono Source Type: journals

Neither genotype nor the gastric colonization site of Helicobacter pylori are predictive factors for the development of erosive esophagitis in patients with peptic ulcer disease, 1 year after eradicationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The incidence of erosive esophagitis in peptic ulcer patients who had their H. pylori eradicated was 19%. No correlation was found between the gastric site colonized by H. pylori or strains expressing CagA and the prevention or development of erosive esophagitis in patients with peptic ulcer disease, 1 year after infection eradication.CONTEXTO: É controverso se a infecção pelo Helicobacter pylori é um fator de proteção ou de predisposição para o desenvolvimento da doença de refluxo gastroesofágico. Cepas mais virulentas tais como as que expressam a citotoxina CagA e o local no estômago de infecção...
Source: Arquivos de Gastroenterologia - November 6, 2009 Category: Gastroenterology Source Type: journals

Quadruple therapy with ecabet sodium, omeprazole, amoxicillin and metronidazole is effective for eradication of Helicobacter pylori after failure of first-line therapy (KDOG0201 Study)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Quadruple therapy including ecabet sodium is useful as second-line eradication treatment for H. pylori. (Source: Journal of Clinical Pharmacy and Therapeutics)
Source: Journal of Clinical Pharmacy and Therapeutics - November 4, 2009 Category: Drugs & Pharmacology Authors: W. Koizumi, S. Tanabe, K. Nakatani, K. Ishido, K. Nishimura, M. Azuma, T. Ae, T. Sasaki, K. Higuchi, C. Katada, N. Nakayama, K. Saigenji Source Type: journals

LAC and LOAD: 4-Drug Regimen Better at Eliminating H. Pylori Than Standard 3-Drug TreatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
LOAD (levofloxacin, omeprazole, nitazoxanide, and doxycycline) is more effective at eradicating Helicobacter pylori than LAC (lansoprazole, amoxicillin, and clarithromycin). Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 2, 2009 Category: Consumer Health News Tags: Gastroenterology Source Type: news

LAC and LOAD: 4-Drug Regimen Better at Eliminating H Pylori Than Standard 3-Drug TreatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
LOAD (levofloxacin, omeprazole, nitazoxanide, and doxycycline) is more effective at eradicating Helicobacter pylori than LAC (lansoprazole, amoxicillin, and clarithromycin). Medscape Medical News (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - November 2, 2009 Category: Gastroenterology Tags: Gastroenterology Source Type: info

In vitro activity of cem-101 against streptococcus pneumoniae and streptococcus pyogenes with defined macrolide resistance mechanisms.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
IN VITRO ACTIVITY OF CEM-101 AGAINST STREPTOCOCCUS PNEUMONIAE AND STREPTOCOCCUS PYOGENES WITH DEFINED MACROLIDE RESISTANCE MECHANISMS. Antimicrob Agents Chemother. 2009 Nov 2; Authors: McGhee P, Clark C, Kosowska-Shick K, Nagai K, Dewasse B, Beachel L, Appelbaum PC CEM-101 had an MIC range against macrolide-susceptible pneumococci of 0.002-0.016 mug/ml and of 0.004-1 mug/ml against macrolide-resistant phenotypes. Only 3 strains with erm(B) +/- mef(A) had CEM-101 MICs of 1 mug/ml and 218/221 strains had CEM-101 MICs </=0.5 mug/ml. CEM-101 MICs were up to 4-fold lower than those of telithromycin against all st...
Source: Antimicrobial Agents and Chemotherapy - November 2, 2009 Category: Microbiology Authors: McGhee P, Clark C, Kosowska-Shick K, Nagai K, Dewasse B, Beachel L, Appelbaum PC Tags: Antimicrob Agents Chemother Source Type: journals

Antimicrobial Resistance in Haemophilus influenzae Respiratory Tract Isolates in Korea: Results of the Nationwide Acute Respiratory Infections Surveillance.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Antimicrobial susceptibility patterns and beta-lactam resistance mechanisms of 544 H. influenzae isolates through the nationwide Acute Respiratory Infections Surveillance (ARIS) network in Korea during 2005 and 2006 were determined. Resistance to ampicillin was 58.5%, followed by cefuroxime (23.3%), clarithromycin (18.7%), cefaclor (17.0%), amoxicillin/clavulanate (10.4%), and chloramphenicol (8.1%). Levofloxacin and cefotaxime were the most active agents tested in this study. beta-lactamase production (52.4%) was the main mechanism of ampicillin resistance, with the rate (96.1%) of TEM-1 type beta-lactamase. According...
Source: Antimicrobial Agents and Chemotherapy - November 2, 2009 Category: Microbiology Authors: Bae S, Lee J, Lee J, Kim E, Lee S, Yu J, Kang Y Tags: Antimicrob Agents Chemother Source Type: journals

Clarithromycin: Hoigne's syndrome: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - October 31, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Efficacy of Two Different Helicobacter pylori Eradication Regimens in Patients With Type 2 Diabetes and the Effect of Helicobacter pylori Eradication on Dyspeptic Symptoms in Patients With Diabetes: A Randomized Controlled Study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS:: These data suggest that the eradication rate of H. pylori with PCA or RCA treatment is lower in patients with type 2 diabetes than in nondiabetics and that successful eradication could decrease dyspeptic symptoms. PMID: 19884816 [PubMed - as supplied by publisher] (Source: The American Journal of the Medical Sciences)
Source: The American Journal of the Medical Sciences - October 30, 2009 Category: Journals (General) Authors: Demir M, Gokturk HS, Ozturk NA, Serin E, Yilmaz U Tags: Am J Med Sci Source Type: journals

The prevalence of clarithromycin resistance-associated mutations in Helicobacter pylori from the west of IrelandEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Content Type Journal ArticleDOI 10.1007/BF03169813 Journal Irish Journal of Medical ScienceOnline ISSN 1863-4362Print ISSN 0021-1265 Journal Volume Volume 170 Journal Issue Volume 170, Supplement 2 / January, 2001 (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - October 29, 2009 Category: Journals (General) Tags: Irish Journal of Medical Science Source Type: journals

Clarithromycin inhibits rhinovirus-induced bacterial adhesions to nasal epithelial cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We investigated the inhibitory effects of clarithromycin (CM) on the rhinovirus (RV)-induced expression of fibronectin (Fn) and carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which act as major receptors for Staphylococcus aureus and Haemophilus influenzae, respectively. We further investigated the effects of CM on secondary S. aureus and H. influenzae adhesions to RV-infected primary human nasal epithelial cells (HNECs).Cells were pretreated with 10 [mu]M CM 24 hours before RV-16 infection and for 48 hours thereafter. The expression levels of Fn and CEACAMs were assayed by reverse transcriptase-polyme...
Source: The Laryngoscope - October 29, 2009 Category: ENT & OMF Authors: Jong Hwan Wang, Si Hyeong Lee, Hyun Ja Kwon, Yong Ju Jang Source Type: journals

New Combination Therapy Looks Promising Against Ulcer BacteriaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Helicobater pylori, a bacteria implicated in peptic ulcers and gastritis, was eradicated in 95 percent patients who took a 7-day course of combination therapy with levofloxacin, omeprazole, nitazoxanide (Alinia®) and doxycycline (LOAD) compared to eradication in only 80.9 percent of patients on lansoprazole, amoxicillin and clarithromycin (LAC) for seven days. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - October 27, 2009 Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news

An outbreak of Mycobacterium fortuitum cutaneous infection associated with mesotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions We identified a large outbreak of rapidly growing mycobacterial lesions among women who received mesotherapy injections in a single beauty salon. (Source: Journal of the European Academy of Dermatology and Venereology)
Source: Journal of the European Academy of Dermatology and Venereology - October 14, 2009 Category: Dermatology Authors: C Quiñones, E Ramalle-Gómara, M Perucha, M-E Lezaun, E Fernández-Vilariño, P García-Morrás, G Simal Source Type: journals

Effects of interactions of antibacterial drugs with each other and with 6-mercaptopurine on in vitro growth of Mycobacterium avium subspecies paratuberculosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions This in vitro study suggests that 6-mercaptopurine may be synergistic with macrolides and rifamycin derivatives against MAP. The activity of clarithromycin against MAP seems to be enhanced by rifampicin. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - October 12, 2009 Category: Microbiology Authors: Krishnan, M. Y., Manning, E. J. B., Collins, M. T. Tags: Original research Source Type: journals

Flucloxacillin, still the empirical choice for putative Staphylococcus aureus infections in intensive care units in the NetherlandsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The empirical choice of flucloxacillin in the case of putative S. aureus infections in patients admitted to ICUs in the Netherlands is still justified. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - October 12, 2009 Category: Microbiology Authors: Rijnders, M. I. A., Deurenberg, R. H., Boumans, M. L. L., Hoogkamp-Korstanje, J. A. A., Beisser, P. S., Stobberingh, E. E., on behalf of the Antibiotic Resistance Surveillance Group Tags: Original research Source Type: journals

Pharmacokinetics and comparative bioavailability study of two clarithromycin suspensions following administration of a single oral dose to healthy volunteers.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of the present study was to compare the pharmacokinetics and bioavailability of two commercial brands of clarithromycin (CAS 81103-11-9) suspensions in healthy male Iranian volunteers. In an open label, single-dose, randomized study with a crossover design an equivalent 500-mg clarithromycin suspension was given orally to each of 24 subjects as a single dose on two treatment days. The treatment periods were separated by a one-week washout period. Blood samples were drawn at different time points and the separated plasma was kept frozen at -20 degrees C for subsequent analysis. The plasma concentrations of the d...
Source: Arzneimittel-Forschung - October 11, 2009 Category: Drugs & Pharmacology Authors: Zakeri-Milani P, Valizadeh H, Ghanbarzadeh S, Nemati M Tags: Arzneimittelforschung Source Type: journals

Antibacterial class is not obviously important in outpatient pneumonia: a meta-analysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: DARE Area: Evidence > Disease Focused Reviews CRD Summary: This review assessed whether improved clinical and mortality outcomes are achieved for outpatient community acquired pneumonia treated with antibacterials with coverage against atypical organisms. The authors concluded that there was no evidence of superiority for any drug comparison. Given some methodological uncertainties identified in the review process, the extent to which this conclusion was reliable was unclear. [The included studies assessed the following oral therapies at differing doses: fluoroquinolones (moxifloxacin, sparfloxacin, levofloxacin...
Source: NeLM - Infectious Diseases - October 8, 2009 Category: Infectious Diseases Source Type: organizations

Ergotamine-induced lower extremity arterial vasospasm presenting as acute limb ischemia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a case of acute lower limb ischemia with characteristic angiography findings of diffuse arterial spasm resulting from use of ergotamine and an erythromycin derivative, clarithromycin. The history of the patient and classic features seen on angiography helped us establish the diagnosis. The patient was successfully treated with low molecular heparin and epidural infusion of bupivacain. Since ergot vasospasm is a self limited and medically treatable condition, interventional radiologists must be aware of ergotamine-induced acute limb ischemia to avoid any unnecessary interventional procedures, unless necrosis and ...
Source: Diagnostic and Interventional Radiology : The Turkish Society of Radiology - October 8, 2009 Category: Radiology Authors: Demir S, Akin S, Tercan F, Aribogan A, Oguzkurt L Tags: Diagn Interv Radiol Source Type: journals

Clinical Management of Rapidly Growing Mycobacterial Cutaneous Infections in Patients after MesotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. This series of rapidly growing mycobacterial cutaneous infections highlights the difficulties in treating such infections and suggests that in vitro susceptibility to antibiotics does not accurately predict their clinical efficacy. (Source: Clinical Infectious Diseases Latest Issue)
Source: Clinical Infectious Diseases Latest Issue - October 8, 2009 Category: Infectious Diseases Tags: article MAJOR ARTICLE Source Type: journals

Amiodarone/ciprofloxacin/clarithromycin interaction: Prolonged QT interval and ventricular tachycardia in an elderly patient: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - October 6, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Efficacy of clarithromycin plus vancomycin in mice with implant-related infection caused by biofilm-forming Staphylococcus aureusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Staphylococcal biofilms have demonstrated resistance to most antibiotics, including VCM. Our in vivo data support the hypothesis that combined treatment using CAM plus VCM may effectively eradicate staphylococcal biofilms in patients with implant-related infection. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00776-009-1366-3Authors Shigeru Fujimura, Tohoku University Research Division for Development of Anti-infection Agents, Institute of Development Aging and Cancer 4-1 Seiryo-machi, Aoba-ku Sendai 980-8575 JapanTetsuro Sato, Sendai Orthopedic Hospital Sendai JapanTo...
Source: Journal of Orthopaedic Science - October 3, 2009 Category: Orthopaedics Tags: Journal of Orthopaedic Science Source Type: journals

Helicobacter pylori infectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
New option(s) added for: H pylori eradication treatments (quadruple regimens compared with triple regimens as second-line treatment) New option for which we found three RCTs. The RCTs found that quadruple regimens as second-line therapies were more effective than triple regimens at eradicating H pylori. Most triple regimens given did not contain a nitroimidazole. Categorised as Likely to be beneficial. H pylori eradication treatments (sequential regimens compared with triple regimens as first-line treatment) New option for which we found...
Source: Clinical Evidence - October 1, 2009 Category: Journals (General) Source Type: journals

Clarithromycin–Amoxycillin-Containing Triple Therapy: A Valid Empirical First-Line Treatment for Helicobacter pylori Eradication in Hong Kong?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The standard 7-day clarithromycin-containing triple therapy is still valid as the most effective empirical first-line eradication therapy for H. pylori infection in Hong Kong, as prevalence of primary resistance of H. pylori to amoxycillin and clarithromycin remains low. Patients who failed their empirical first-line eradication therapy should undergo H. pylori susceptibility testing to guide further treatment. (Source: Helicobacter)
Source: Helicobacter - October 1, 2009 Category: Gastroenterology Authors: Ivan F.N. Hung, Pierre Chan, Sally Leung, Fion S.Y. Chan, Axel Hsu, David But, Wai Kay Seto, Siu Yin Wong, Chi Kuen Chan, Qing Gu, Teresa S.M. Tong, Ting Kin Cheung, Kent Man Chu, Benjamin C.Y. Wong Tags: ORIGINAL ARTICLES Source Type: journals

Stomach-site specific drug delivery system of clarithromycin for eradication of Helicobacter pylori.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Gellan gum based floating beads containing clarithromycin (FBC) were prepared by iontotropic gelation method for stomach-specific drug delivery against Helicobacter pylori. The scanning electron microscope photograph indicated that prepared beads were spherical in shape with rough outer surface. Formulation variables such as concentrations of gellan, calcium carbonate and drug loading influenced the in vitro drug release characteristics of prepared beads. In vitro release rate of clarithromycin was corrected using first order degradation rate constant which is degraded significantly during the release study in simulate...
Source: Chemical and Pharmaceutical Bulletin - September 30, 2009 Category: Drugs & Pharmacology Authors: Rajinikanth PS, Mishra B Tags: Chem Pharm Bull (Tokyo) Source Type: journals

Biaxin, Biaxin XL (Clarithromycin) - updated on RxListEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Biaxin, Biaxin XL (Clarithromycin) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)
Source: RxList - New and Updated Drug Monographs - September 25, 2009 Category: Drugs & Pharmacology Source Type: consumer

The Cochrane Library and Treatment for Community Acquired Pneumonia in Children: An Overview of ReviewsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Globally, pneumonia is the leading cause of death among children and also results in significant morbidity. The most common treatment options include anti-pyretics and antibiotics. Other treatments include vitamins and over-the-counter cough syrup.This overview presents a summary of the results of previous Cochrane reviews on the treatment of community acquired pneumonia (CAP) in children.The Cochrane Database of Systematic Reviews was searched for all systematic reviews examining the treatment of pediatric pneumonia or lower respiratory tract infections. All reviews that were under the heading "pneumonia" on the Cochrane ...
Source: Evidence-Based Child Health: A Cochrane Review Journal - September 15, 2009 Category: Pediatrics Authors: Kelly Russell, Joan Robinson, Diane Yorke, Inge Axelsson Tags: Pneumonia Source Type: journals

Clarithromycin: Rhabdomyolysis: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - September 14, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Clarithromycin/simvastatin interaction: Rhabdomyolysis in an elderly patient: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - September 14, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Pediatric bronchogenic cyst complicated by atypical mycobacterium infection: a case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Bronchogenic cyst should be included in the differential diagnosis of a child with cough, dyspnea, and fever. Although rare, we stress the importance of keeping mycobacterial infection in mind in cases of an infected cyst. Acid-fast culture should be done on sputum and cyst contents. Due to the frequency of negative cultures, stains should also be performed on resected cyst specimens. Antibiotic therapy should be considered and administered based on the extent of infection. All symptomatic or enlarging cysts warrant surgical excision. Prophylactic removal of asymptomatic cysts is recommended due to higher rates...
Source: Cases Journal - September 9, 2009 Category: Journals (General) Source Type: journals

The role of efflux pumps in macrolide resistance in Mycobacterium avium complexEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This study demonstrates that efflux pumps play an important role in MAC resistance to antibiotics. (Source: International Journal of Antimicrobial Agents)
Source: International Journal of Antimicrobial Agents - September 9, 2009 Category: Drugs & Pharmacology Authors: Liliana Rodrigues, Daniela Sampaio, Isabel Couto, Diana Machado, Winfried V. Kern, Leonard Amaral, Miguel Viveiros Tags: Full length articles Source Type: journals

Annual Change of Primary Resistance to Clarithromycin among Helicobacter pylori Isolates from 1996 through 2008 in JapanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The resistance rate of H. pylori infection to clarithromycin in Japan has increased gradually to approximately 30% from 1996 through 2004, and remained unchanged since 2004. Elderly and females were at high risk of having resistance to clarithromycin. Our results suggested that the level of clarithromycin resistance in Japan has now risen to the point where it should no longer be used as empiric therapy. (Source: Helicobacter)
Source: Helicobacter - September 8, 2009 Category: Gastroenterology Authors: Noriyuki Horiki, Fumio Omata, Masayo Uemura, Shoko Suzuki, Naoki Ishii, Yusuke Iizuka, Katsuyuki Fukuda, Yoshiyuki Fujita, Masaki Katsurahara, Toshiyuki Ito, Gabazza Esteban Cesar, Ichiro Imoto, Yoshiyuki Takei Tags: ORIGINAL ARTICLES Source Type: journals

Variables Influencing Outcome of Helicobacter pylori Eradication Therapy in South ChinaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The eradication rate with a PPI, metronidazole and amoxicillin triple therapy was unacceptably low in South China. These results suggest that studies of the eradication of H. pylori infection in China must take into account antibiotic resistance as well as patient occupation, gender, and protocol compliance. Gastric cancer and peptic ulcer disease are both important in China making methods to effectively and efficiently eradicate H. pylori a priority. (Source: Helicobacter)
Source: Helicobacter - September 8, 2009 Category: Gastroenterology Authors: Wenzhi Cai, Liping Zhou, Wei Ren, Ling Deng, Min Yu Tags: ORIGINAL ARTICLES Source Type: journals

Antimicrobial susceptibilities of Mycoplasma genitalium by broth dilution and quantitative PCR.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Only limited information regarding the antimicrobial susceptibilities of Mycoplasma genitalium is available because of difficulties in isolating M. genitalium strains from clinical specimens. Antimicrobial susceptibilities of 15 clinical isolates, 7 ATCC strains and an early-passage of the M30 strain were examined by the broth-dilution method. Azithromycin, clarithromycin, sitafloxacin and moxifloxacin were the most active drugs to M. genitalium and their MIC90 values were 0.002, 0,008, 0.125 and 0.125 mg/liter, respectively. PMID: 19738019 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)
Source: Antimicrobial Agents and Chemotherapy - September 7, 2009 Category: Microbiology Authors: Hamasuna R, Jensen JS, Osada Y Tags: Antimicrob Agents Chemother Source Type: journals

Clarithromycin: Visual hallucinations in children: 2 case reportsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - September 7, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Bactericidal activities of the cationic steroid CSA-13 and the cathelicidin peptide LL-37 against Helicobacter pylori in simulated gastric juice.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These data indicate that cholic acid-based antimicrobial agents such as CSA-13 resist proteolytic degradation and inhibition by mucin and have potential for treatment of H. pylori infections, including those caused by the clarithromycin and/or metronidazole-resistant strains. (Source: BMC Microbiology - Latest articles)
Source: BMC Microbiology - Latest articles - September 2, 2009 Category: Microbiology Authors: Katarzyna LeszczynskaAndrzej NamiotDavid FeinQi WenZbigniew NamiotPaul SavageScott DiamondPaul JanmeyRobert Bucki Source Type: journals

Adult community-acquired pneumonia caused by macrolide resistant Mycoplasma pneumoniaeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 28-year-old woman with community-acquired pneumonia was treated with sulbactam/ampicillin and clarithromycin, but failed to show any improvement after 4 days. The antibiotic regimen was changed to pazufloxacin and rapid clinical improvement was seen. Mycoplasma pneumoniae was identified as the causative agent, and adenine (A) to guanine (G) mutation at position 2063 in domain V of the 23S rRNA was noted in the isolate. The minimum inhibitory concentration of macrolide antibiotics, including clarithromycin, of this isolate was greatly elevated. (Source: Respirology)
Source: Respirology - September 1, 2009 Category: Respiratory Medicine Authors: Rie ISOZUMI, Hiroyuki YOSHIMINE, Miyuki MOROZUMI, Kimiko UBUKATA, Koya ARIYOSHI Source Type: journals

Nontuberculous Mycobacterium Disease With Pleural Empyema in a Patient With Advanced AIDS.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a case of a patient with advanced AIDS, not on antiretroviral therapy, who presented with massive pleural empyema and splenic and liver abscess secondary to Mycobacterium avium-intracellulare complex. She was a 42-year-old female who was admitted with fever, chills, weight loss, and productive cough of 3 weeks duration. Her pleural fluid cultures were positive for Mycobacterium avium-intracellulare complex, and no other organism was identified. Our patient had good outcome after treatment with antitubercular agents (isoniazid, rifabutin, and clarithromycin). PMID: 19726970 [PubMed - as supplied by publisher]...
Source: The American Journal of the Medical Sciences - August 31, 2009 Category: Journals (General) Authors: Haider A, Schliep T, Zeana C Tags: Am J Med Sci Source Type: journals

Free Transport of Water and CO2 in Nonporous Hydrophobic Clarithromycin Form II CrystalsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Journal of the American Chemical Society, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of the American Chemical Society)
Source: Journal of the American Chemical Society - August 28, 2009 Category: Chemistry Tags: article Source Type: journals

Diagnosis of Helicobacter pylori InfectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The articles published this last year in the field of Helicobacter pylori diagnosis reported the development of in vivo histology, small improvements in some invasive methods (urease test, culture, and histology) and new kits for the stool antigen tests. They also contributed to increasing our knowledge, by further exploration into specific conditions for the urea breath test and into the significance of cagA antibodies. The role of serum markers of atrophy was also confirmed. Molecular methods are still being developed for direct genotyping, detection of H. pylori and its clarithromycin resistance, either by polymerase ch...
Source: Helicobacter - August 24, 2009 Category: Gastroenterology Authors: Lurdes Monteiro, Mónica Oleastro, Philippe Lehours, Francis Mégraud Tags: REVIEW ARTICLES Source Type: journals

Treatment of Helicobacter pylori InfectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article aims to examine current best practice in the field reference to first-line, second-line, rescue and emerging treatment regimens for Helicobater pylori eradication. The recommended first-line treatment in published guidelines in Europe and North American is proton pump inhibitor combined with amoxicillin and clarithromycin being the favoured regimen. Rates of eradication with this regimen however are falling alarmingly due to a combination of antibiotic resistance and poor compliance with therapy. Bismuth based quadruple therapies and levofloxacin based regimes have been shown to be effective second line regime...
Source: Helicobacter - August 24, 2009 Category: Gastroenterology Authors: Anthony O'Connor, Javier Gisbert, Colm O'Morain Tags: REVIEW ARTICLES Source Type: journals

Evaluation of CYP3A activity in humans using three different parameters based on endogenous cortisol metabolism.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion:Although Cl(m(6beta)) and 6beta-OHF/F can reflect the decline in CYP3A activity, the impression they provide is neither accurate nor complete. AUC(F) is completely ineffective for evaluating variations in CYP3A activity. MDZ administration had no evident effects on either cortisol metabolism or excretion over a period of 24 h.Acta Pharmacologica Sinica advance online publication, 24 August 2009; doi: 10.1038/aps.2009.116. PMID: 19701237 [PubMed - as supplied by publisher] (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - August 23, 2009 Category: Drugs & Pharmacology Authors: Luo X, Li XM, Hu ZY, Cheng ZN Tags: Acta Pharmacol Sin Source Type: journals

Prolonged Mycoplasma pneumoniae infection in an elderly patient with community-acquired pneumoniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract An 81-year-old woman with no underlying systemic illness was hospitalized with fever, muscle weakness, and sputum without cough for 2 days. Chest imaging showed consolidation in the left lower lobe. Real-time polymerase chain reaction (PCR) for six respiratory bacteria and 12 respiratory viruses performed on sputum obtained on admission showed Mycoplasma pneumoniae DNA, with no evidence of other pathogens. M. pneumoniae was confirmed to be the causative agent by serologic data. Variation of mycoplasma quantity in subsequent sputa was analyzed because of persistent sputum production despite treatment ...
Source: Journal of Infection and Chemotherapy - August 17, 2009 Category: Infectious Diseases Tags: Journal of Infection and Chemotherapy Source Type: journals

Amoxicillin/clarithromycin/pantoprazole: Anaphylaxis in a patient with amoxicillin intolerance: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - August 17, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Prophylactic effect of clarithromycin in skin flap complications in cochlear implants surgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To assess the usefulness of postoperative clarithromycin versus classical postoperative prophylaxis with occlusive dressing to prevent cochlear implant skin flap complications.Cohort study.Surgical site infections were compared in four groups: 1) ceramic/classical postoperative cares (21 patients), 2) titanium-silicon/classical postoperative cares (75), 3) ceramic/clarithromycin (24), and 4) titanium-silicon/clarithromycin (76). Preoperative ceftriaxone was systematically used in all patients in all four groups. Patients were followed up for at least 4 months. Attributable risk and number needed to treat were calculated.Al...
Source: The Laryngoscope - August 16, 2009 Category: ENT & OMF Authors: Juan Garcia-Valdecasas, Jose Juan Jiménez-Moleon, Manuel Sainz, Constanza Fornieles, Jose Manuel Ballesteros Source Type: journals

Rituximab (B-cell depleting antibody) associated lung injury (RALI): A pediatric case and systematic review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Pulmonary toxicity of delayed onset is a rare complication of B-lymphocyte depleting antibody therapy and has been almost exclusively reported in older patients with B-cell malignancies.To describe a pediatric patient with rituximab-associated lung injury (RALI), to systematically analyze previous reports of pulmonary complications, and to summarize common clinico-pathological features, treatment, and outcome.A teenage boy with focal segmental glomerulosclerosis (FSGS) presented with progressive dyspnea, fever, hypoxemia and fatigue 18 days after the completion of a second course of rituximab infusions for calcineurin inhi...
Source: Pediatric Pulmonology - August 12, 2009 Category: Respiratory Medicine Authors: Martin Bitzan, Mark Anselmo, Lucy Carpineta Source Type: journals

BSAC standardized disc susceptibility testing method (version 8)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
There have been considerable changes to the format of the recommendations since the previous version (version 7). The majority of the footnotes to the tables have been removed and the notations added to the end column; it is hoped that this change will avoid confusion in interpretation. Antibiotics have been separated into groups, e.g. β-lactams, aminoglycosides, etc. Recommendations for urinary tract infections (UTIs) have been removed for most agents except for those that are administered solely for the treatment of uncomplicated UTIs or where there are limited recommendations for specific organisms, e.g. trimethopr...
Source: Journal of Antimicrobial Chemotherapy - August 10, 2009 Category: Microbiology Authors: Andrews, J. M., for the BSAC Working Party on Susceptibility Testing Tags: Original research Source Type: journals