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Plausible--yes. But ...Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19905898 [PubMed - in process] (Source: Climacteric)
Source: Climacteric - November 15, 2009 Category: Geriatrics Authors: Fenton A, Panay N Tags: Climacteric Source Type: journals

The endometrium--from estrogens alone to TSECs.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article reviews publications dating back more than a century describing investigations of the endometrium, including those examining the relationship between endometrial hyperplasia and carcinoma, the influence of estrogens on the endometrium, and strategies for protecting the endometrium from unopposed estrogen stimulation. Endometrial hyperplasia and carcinoma studies date from before 1900. The influence of endogenous estrogens on the endometrium became evident with observations of endometrial hyperplasia and/or carcinoma in women with estrogen-secreting tumors or polycystic ovarian disease. Later, observational stu...
Source: Climacteric - November 15, 2009 Category: Geriatrics Authors: Pickar JH Tags: Climacteric Source Type: journals

Hormone replacement therapy after breast cancer: attitudes of women eligible in a randomized trial.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion A patient's decision to accept or decline participation in the Stockholm trial was influenced by her objective risk of breast cancer recurrence and reflected her attitude to risk, uncertainty and preference to be active in treatment decisions. PMID: 19905900 [PubMed - in process] (Source: Climacteric)
Source: Climacteric - November 15, 2009 Category: Geriatrics Authors: Wallberg B, von Schoultz E, Bolund C, Bergh J, Wilking N Tags: Climacteric Source Type: journals

Association between estrogen receptor gene polymorphisms and breast density in postmenopausal women.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Our data suggested that the polymorphism XbaI may be strongly related to mammographic density. PMID: 19905901 [PubMed - in process] (Source: Climacteric)
Source: Climacteric - November 15, 2009 Category: Geriatrics Authors: de Moura Ramos EH, Martinelli S, Silva I, Nazário A, Facina G, Costa A, Carvalho C, Souza N Tags: Climacteric Source Type: journals

Acid ceramidase 1 expression correlates with a better prognosis in ER-positive breast cancer.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: ASAH1 is an estrogen-dependent member of the sphingolipid metabolism, which might provide further prognostic information in ER-positive breast cancers. PMID: 19905902 [PubMed - in process] (Source: Climacteric)
Source: Climacteric - November 15, 2009 Category: Geriatrics Authors: Ruckhäberle E, Holtrich U, Engels K, Hanker L, Gätje R, Metzler D, Karn T, Kaufmann M, Rody A Tags: Climacteric Source Type: journals

Risk of gynecological cancers in users of estradiol/dydrogesterone or other HRT preparations.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: This study provides evidence that the risk of developing gynecological cancers with E/D use of several months to a few years is similar to the risks of developing gynecological cancer without HRT or use of other HRT. PMID: 19905903 [PubMed - in process] (Source: Climacteric)
Source: Climacteric - November 15, 2009 Category: Geriatrics Authors: Schneider C, Jick SS, Meier CR Tags: Climacteric Source Type: journals

Risk of hypoactive sexual desire disorder and associated factors in a cohort of oophorectomized women.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Nearly three out of four women who had undergone bilateral oophorectomy were at risk of suffering HSDD; this risk was increased when less than 5 years since surgical menopause had elapsed. The use of hormone replacement therapy was associated with lower HSDD risk. PMID: 19905904 [PubMed - in process] (Source: Climacteric)
Source: Climacteric - November 15, 2009 Category: Geriatrics Authors: Castelo-Branco C, Palacios S, Combalia J, Ferrer M, Traveria G Tags: Climacteric Source Type: journals

LEI (Lack of tEstosterone Impact) survey in a clinical sample with surgical menopause.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: These data suggest that women experience significant vaginal dryness and low sexual desire and report a significant distress in the relationship with their partner after surgical menopause. Sexual counseling is mandatory in order to discuss potential therapeutic strategies, including testosterone use. PMID: 19905905 [PubMed - in process] (Source: Climacteric)
Source: Climacteric - November 15, 2009 Category: Geriatrics Authors: Nappi RE, Lello S, Melis GB, Albani F, Polatti F, Genazzani AR Tags: Climacteric Source Type: journals

Prescription pattern of traditional Chinese medicine for climacteric women in Taiwan.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Women of climacteric age in Taiwan utilized TCM more often than other age groups. To deal with multiple symptoms and/or diseases among climacteric women, new prescription patterns of combining two or more herbal formulae have evolved. Studies on safety issues and drug-herb interactions are warranted for future research. PMID: 19905906 [PubMed - in process] (Source: Climacteric)
Source: Climacteric - November 15, 2009 Category: Geriatrics Authors: Yang YH, Chen PC, Wang JD, Lee CH, Lai JN Tags: Climacteric Source Type: journals

The menopausal experience among indigenous women of Sarawak, Malaysia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The menopausal symptoms in this study correspond to those in other studies on Asian women but the prevalence of typical and classical menopausal symptoms was lower compared to studies on Caucasian women. The perimenopausal women had the most significant decrease in quality of life, followed by postmenopausal women and premenopausal women. Vasomotor symptoms had a predominant influence on the quality of life. PMID: 19905907 [PubMed - in process] (Source: Climacteric)
Source: Climacteric - November 15, 2009 Category: Geriatrics Authors: Syed Alwi SA, Lee PY, Awi I, Mallik PS, Md Haizal MN Tags: Climacteric Source Type: journals

Is the Wii Fit a new-generation tool for improving balance, health and well-being? A pilot study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Activity fostered by Wii Fit showed an immediate effect on balance and strength that needs confirmation by statistically powered studies. PMID: 19905991 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - November 12, 2009 Category: Geriatrics Authors: Nitz JC, Kuys S, Isles R, Fu S Tags: Climacteric Source Type: journals

Insomnia in Japanese peri- and postmenopausal women.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Insomnia in Japanese peri- and postmenopausal women correlates more strongly with depressed mood than with vasomotor symptoms. Cessation of smoking may improve the women's sleep quality, and hormone therapy and nightly hypnotics are both effective treatments. PMID: 19886814 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - November 3, 2009 Category: Geriatrics Authors: Terauchi M, Obayashi S, Akiyoshi M, Kato K, Matsushima E, Kubota T Tags: Climacteric Source Type: journals

Effects of aerobic exercise training on visceral fat and serum adiponectin concentration in ovariectomized rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion These results suggest that 8-week exercise training induces a decrease in visceral fat, and this reduction without weight loss does not change serum adiponectin levels and insulin sensitivity in ovariectomized rats. PMID: 19886815 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - November 3, 2009 Category: Geriatrics Authors: Damirchil A, Mehdizade R, Ansar MM, Soltani B, Babaei P Tags: Climacteric Source Type: journals

Postmenopausal hormone therapy and cognition: effects of timing and treatment type.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion 'Early start' of estrogen-only hormone therapy was associated with reduced risk of global cognitive decline, and 'early start' estrogen-only and estrogen/progestogen hormone therapies showed increased risks of general memory decline. Even though this study did not have the power to discriminate between minor and mixed effects, it suggests that cognitive effects of hormone therapies may be mixed, depending on cognitive domain and timing of use/type of preparation. PMID: 19886816 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - November 3, 2009 Category: Geriatrics Authors: Khoo SK, O'Neill S, Byrne G, King R, Travers C, Tripcony L Tags: Climacteric Source Type: journals

Comparative effects of continuous combined hormone therapy and tibolone on body composition in postmenopausal women.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The effect of tibolone on body composition is favorable and therefore tibolone may be regarded as an alternative to continuous combined hormone therapy in postmenopausal women. PMID: 19848555 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - October 22, 2009 Category: Geriatrics Authors: Ziaei S, Moaya M, Faghihzadeh S Tags: Climacteric Source Type: journals

Hormone therapy and risk of venous thromboembolism among postmenopausal women.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Venous thromboembolism, either deep vein thrombosis or pulmonary embolism, is a serious side-effect of postmenopausal hormone therapy. Current use of oral estrogens increases the risk of venous thromboembolism, especially during the first year of treatment, but past users of hormone therapy have a similar risk as never-users. Among women at high risk for venous thromboembolism (for example, thrombogenic mutations, obesity), oral estrogens use further enhances the thrombotic risk. Recent studies have shown that transdermal estrogens might be safe with respect to thrombotic risk. The difference in thrombotic risk between...
Source: Climacteric - October 18, 2009 Category: Geriatrics Authors: Canonico M, Scarabin PY Tags: Climacteric Source Type: journals

Menopause and hormone replacement. Introduction.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19811231 [PubMed - in process] (Source: Climacteric)
Source: Climacteric - October 16, 2009 Category: Geriatrics Authors: Sturdee DW Tags: Climacteric Source Type: journals

Incidence and mortality of cardiovascular disease in postmenopausal women world-wide and relevance for preventive strategies.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
World-wide, cardiovascular disease is mainly seen as a male problem, whereas breast cancer is considered to be the most important chronic disease in women. However, cardiovascular disease is the largest single cause of death also in women, accounting for approximately one-third of the mortality, while breast cancer is responsible for less than 5% of the mortality. Physicians and women are equally unaware of these numbers. From a public health viewpoint, morbidity might be even more important, given the fact that therapeutic strategies have improved in the last decades, and disease fatality has been decreasing. In this ...
Source: Climacteric - October 16, 2009 Category: Geriatrics Authors: van der Schouw YT Tags: Climacteric Source Type: journals

Mechanisms of action of estrogen receptors in vascular cells: relevance for menopause and aging.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Estrogen exerts pleiotropic functions on the cardiovascular system through binding to estrogen receptors (ERs). Traditionally, ERs have been recognized as transcription factors regulating the expression of target genes. In the past decades, however, numerous studies have revealed rapid actions of estrogen in different systems, especially in non-reproductive tissues such as the cardiovascular system. At this level, estrogen triggers rapid vasodilatation, exerts anti-inflammatory effects, regulates vascular cell growth and migration, and confers protection to cardiomyocytes. These so-called 'extranuclear actions' do not ...
Source: Climacteric - October 16, 2009 Category: Geriatrics Authors: Simoncini T Tags: Climacteric Source Type: journals

Estrogen receptor actions on vascular biology and inflammation: implications in vascular pathophysiology.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Whereas hormonal therapy (HT) may increase the risk of coronary heart disease (CHD) and stroke in menopausal women, epidemiological studies (protection in premenopausal women) suggest and experimental studies (prevention of fatty streak development in animals) demonstrate a major atheroprotective action of estradiol (E2). The understanding of the deleterious and beneficial effects of estrogens is thus required at both a cellular and molecular level. Both the endothelium and the immuno-inflammatory system play a key role in the development of fatty streak deposit as well as in the rupture of the atherosclerotic plaque. ...
Source: Climacteric - October 16, 2009 Category: Geriatrics Authors: Arnal JF, Laurell H, Fontaine C, Billon A, Calippe B, Lenfant F, Gourdy P Tags: Climacteric Source Type: journals

Estrogen actions in the cardiovascular system.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This brief review summarizes the current state of the field for estrogen receptor actions in the cardiovascular system and the cardiovascular effects of hormone replacement therapy (HRT). It is organized into three parts: a short Introduction and overview of the current view of how estrogen works on blood vessels; a summary of the current status of clinical information regarding HRT and cardiovascular effects; and an update on state-of-the-art mouse models of estrogen action using estrogen receptor knockout mice. PMID: 19811235 [PubMed - in process] (Source: Climacteric)
Source: Climacteric - October 16, 2009 Category: Geriatrics Authors: Mendelsohn ME Tags: Climacteric Source Type: journals

Cardiovascular risk and events in polycystic ovary syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Young women with polycystic ovary syndrome (PCOS) present a high risk for cardiovascular disease because of the presence of abdominal obesity, insulin resistance and androgen excess. In addition, they present with endothelial dysfunction and early signs of atherosclerosis (increased carotid intima-media thickness and increased coronary calcium). However, the evidence of increased cardiovascular events during the postmenopausal age is relatively small, although some recent studies have indicated a slight increase in the severity of cardiovascular disease in women who had PCOS during their fertile age. The discrepancy be...
Source: Climacteric - October 16, 2009 Category: Geriatrics Authors: Carmina E Tags: Climacteric Source Type: journals

Premature menopause increases cardiovascular risk.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Premature menopause and bilateral oophorectomy in young women are associated with an increased incidence of cardiovascular disease, myocardial infarction and overall mortality. Observational studies suggest an interval of 5-10 years between loss of ovarian function and the increased risk of cardiovascular disease. This finding is consonant with a published autopsy study of women who had undergone bilateral oophorectomy. The progression of atherosclerosis is retarded with the use of estrogen replacement therapy in non-human primates and women. Hormone therapy reduced the incidence of cardiovascular disease in women foll...
Source: Climacteric - October 16, 2009 Category: Geriatrics Authors: Archer DF Tags: Climacteric Source Type: journals

Vasomotor symptoms and cardiovascular risk.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Climacteric complaints are the main indication for hormone replacement therapy (HRT) in the clinical practice. Observational studies demonstrating a protective effect of HRT on cardiovascular disease (CVD) were conducted in early menopausal, young, symptomatic women. Vasomotor symptoms correlate with lower level of plasma antioxidant activity, an increased cardiovascular reactivity to stressful situations, elevated cholesterol, higher sympathetic nerve activity, impaired flow-mediated dilation, hypertension and a higher risk of aortic calcification. All the available findings indicate that hot flushes can be seen as a ...
Source: Climacteric - October 16, 2009 Category: Geriatrics Authors: Gambacciani M, Pepe A Tags: Climacteric Source Type: journals

Blood pressure through aging and menopause.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Together with the aging process, hypertension is the main risk factor contributing to the increase in cardiovascular morbidity and mortality in postmenopausal women, with a prevalence of around 60% in women older than 65 years. Considering that hypertension is a modifiable risk factor, the understanding of its epidemiology and pathophysiology and the development of appropriate therapeutic strategies are conceivably crucial in reducing cardiovascular risk. The high prevalence of hypertension in older women is largely due to the progressive stiffening of the arterial structure which accompanies the aging process in both ...
Source: Climacteric - October 16, 2009 Category: Geriatrics Authors: Taddei S Tags: Climacteric Source Type: journals

Cardiovascular aspects of menopausal hormone replacement therapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Cardiovascular disease is the leading cause of death in postmenopausal women in Western countries. Despite preventive strategies, in the past decades, the incidence of cardiovascular events has shown a decline in men but a rise in women, matching the growth of the population of postmenopausal women. Several epidemiological findings suggest the causative role of ovarian hormone deficiency in the development of cardiovascular disease in women. Observational and randomized studies have suggested that initiation of hormone replacement therapy in early postmenopause could be beneficial from a cardiovascular point of view. C...
Source: Climacteric - October 16, 2009 Category: Geriatrics Authors: Rosano GM, Vitale C, Fini M Tags: Climacteric Source Type: journals

The hemostatic system through aging and menopause.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The process of aging is accompanied by several modifications in the hemostatic system at different levels (blood coagulation, fibrinolysis, platelet activity, vascular endothelium). These changes may explain the higher incidence of arterial and venous thrombosis in the elderly compared to young people. Genetic and environmental factors modulate in different combinations the expression of proteins involved in the hemostatic process. Among the latter, diet and smoking habits play an important role, as well as physical exercise and, for women, hormonal status. A gradual and progressive development of a low-grade inflammat...
Source: Climacteric - October 16, 2009 Category: Geriatrics Authors: Bucciarelli P, Mannucci PM Tags: Climacteric Source Type: journals

Quality of life and sexuality issues in aging women.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Quality of life may decrease after menopause. Hormone replacement therapy remains the first-line and most effective treatment for menopausal symptoms and improvement of low quality of life due to estrogen deficiency. The decrease of health-related quality of life in women suffering from cardiovascular disease may be superimposed on the decrease of quality of life induced by menopause itself. Postmenopausal women with acute cardiovascular disease have a significantly higher probability of death than men of the same age. Quality of life predicts long-term mortality. A myocardial infarction does not automatically interdic...
Source: Climacteric - October 16, 2009 Category: Geriatrics Authors: Birkhäuser MH Tags: Climacteric Source Type: journals

Cardiovascular risk assessment in postmenopausal women: the role of the gynecologist.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The gynecologist is often the only physician a woman consults on a regular basis and therefore gynecologists play a crucial role in the primary prevention of cardiovascular disease. Cardiovascular risk factors in women entering the menopausal transition are poorly managed, partly due to the fact that primary-care physicians, gynecologists and cardiovascular physicians often fail to identify cardiovascular risk factors and also undertreat women at increased cardiovascular risk. Furthermore, most women are not well informed about their cardiovascular risk profile. Gynecologists and cardiologists should work together as a...
Source: Climacteric - October 16, 2009 Category: Geriatrics Authors: Mikkola TS Tags: Climacteric Source Type: journals

Lifestyle and diet in postmenopausal women.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Diet and nutritional habits have a pivotal role in maintaining human health. Unhealthy eating, obesity and nutritional deficiencies may lead to various diseases. However, a most important component of lifestyle relates to physical activity. Sedentary people fare less well than those who exercise regularly. The benefits of exercise can be demonstrated in many bodily organs. The most frequently studied effect of exercise is reduction in cardiovascular morbidity and mortality, but positive effects on the musculoskeletal system, breast cancer risk, mood and cognition, and quality of life have been recorded as well. In many...
Source: Climacteric - October 16, 2009 Category: Geriatrics Authors: Pines A Tags: Climacteric Source Type: journals

Comparative effects of conventional vs. novel hormone replacement therapy on blood pressure in postmenopausal women.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Menopause is commonly characterized by an increase in blood pressure. Higher blood pressure may partially explain the elevated risk for cardiovascular events observed in postmenopausal women. There is a graded relationship between blood pressure and cardiovascular risk which extends to levels of blood pressure well below 140/90 mmHg, the classical established blood pressure limit for the diagnosis of hypertension. Despite this knowledge and the wide availability of consensus treatment guidelines for hypertension, high blood pressure remains untreated or poorly treated in many postmenopausal patients. It is clear that n...
Source: Climacteric - October 16, 2009 Category: Geriatrics Authors: Preston RA Tags: Climacteric Source Type: journals

Coronary heart disease and hormone replacement therapy after the menopause.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The discordance in coronary heart disease (CHD) outcome between randomized, controlled trials and observational studies of hormone replacement therapy (HRT) is likely the result of the dissimilar cohorts studied. This observation led to the formation of the timing hypothesis that benefits and risks of HRT depend upon age of HRT initiation and/or time of HRT initiation in relation to menopause. This hypothesis has been supported with data from large, randomized, controlled trials that have studied HRT and selective estrogen receptor modulators (SERMs) in the prevention of CHD. Initiation of HRT in women <60 years of ...
Source: Climacteric - October 16, 2009 Category: Geriatrics Authors: Hodis HN, Mack WJ Tags: Climacteric Source Type: journals

Hormone therapy and risk of venous thromboembolism among postmenopausal women.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Venous thromboembolism, either deep vein thrombosis or pulmonary embolism, is a serious side-effect of postmenopausal hormone therapy. Current use of oral estrogens increases the risk of venous thromboembolism, especially during the first year of treatment, but past users of hormone therapy have a similar risk as never-users. Among women at high risk for venous thromboembolism (for example, thrombogenic mutations, obesity), oral estrogens use further enhances the thrombotic risk. Recent studies have shown that transdermal estrogens might be safe with respect to thrombotic risk. The difference in thrombotic risk between...
Source: Climacteric - October 16, 2009 Category: Geriatrics Authors: Canonico M, Scarabin PY Tags: Climacteric Source Type: journals

The risk of stroke in postmenopausal women receiving hormonal therapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Stroke affects one in five women and is the third leading cause of death in the United States. The incidence increases with age, and the number of females experiencing a stroke is similar to the number of men, unlike in coronary disease, where the number of females suffering from the disease is lower before menopause and then slowly becomes equal to the number of men. There are multiple risk factors for stroke, but the most significant ones influencing the relationship between hormones and stroke are obesity, hypertension and smoking. There have been multiple studies looking at the relationship between hormones and str...
Source: Climacteric - October 16, 2009 Category: Geriatrics Authors: Lobo RA Tags: Climacteric Source Type: journals

Type and route of estrogen administration.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hormone replacement therapy (HRT) can be administered orally and non-orally. Providing equivalent doses are given, all forms of HRT can equally relieve menopausal symptoms and prevent bone loss and osteoporosis. Different routes of administration will have differing metabolic effects, with oral HRT producing a hepatic first-pass effect not seen with non-oral HRT. The first-pass effect can produce benefits including larger reductions in low density lipoprotein cholesterol, lipoprotein(a) and insulin resistance, and larger increases in high density lipoprotein cholesterol. Unwanted effects are seen in increases in trigly...
Source: Climacteric - October 16, 2009 Category: Geriatrics Authors: Stevenson JC Tags: Climacteric Source Type: journals

Estrogen dose: the cardiovascular impact.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
One of the main concerns from the large secondary and primary prevention cardiovascular trials such as the Heart and Estrogen/progestin Replacement Study and the Women's Health Initiative (WHI) study was that there appeared to be an increased risk of coronary events in the first years of usage. These findings were initially surprising bearing in mind that observational trials had previously shown benefit. Subsequent analyses have confirmed that the risks were primarily in the over-seventies age group. In the younger age groups (50-59 years), there was a trend towards reduction of risk and a significant reduction in all...
Source: Climacteric - October 16, 2009 Category: Geriatrics Authors: Panay N Tags: Climacteric Source Type: journals

Different cardiovascular effects of progestins according to structure and activity.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Following the publication of the Women's Health Initiative study, the controversy was raised regarding the role of progestins in hormonal replacement therapy (HRT). Some of the most prescribed molecules, with partial androgenic or glucocorticoid activity, have been shown to oppose partially the beneficial effect of estrogens on surrogate markers of cardiovascular disease risk. Unfortunately, this concern has been directed towards progestins as a class effect, although striking differences exist among the types of molecules used. The synthetic progestins used in HRT have varying pharmacologic properties depending on the...
Source: Climacteric - October 16, 2009 Category: Geriatrics Authors: Nath A, Sitruk-Ware R Tags: Climacteric Source Type: journals

Androgen replacement therapy and cardiovascular function.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Androgens play a primary role in female physiopathology. The age-related decline in the production of ovarian and adrenal androgens may significantly affect women's health. Scanty studies have been designed to establish whether androgen deficiency might directly affect cardiovascular biology and whether it might be a risk factor for cardiovascular disease in women during reproductive aging. The present short review examines the effect of androgen on the cardiovascular system, with particular regard to dehydroepiandrosterone and testosterone replacement in postmenopausal women. PMID: 19811252 [PubMed - in process] (Source: Climacteric)
Source: Climacteric - October 16, 2009 Category: Geriatrics Authors: Genazzani AR, Pluchino N Tags: Climacteric Source Type: journals

Clinical issues regarding cardiovascular disease and selective estrogen receptor modulators in postmenopausal women.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Selective estrogen receptor modulators (SERMs) have offered the promise of reducing the burden of coronary artery disease (CAD) in postmenopausal women, based on the positive effects recorded on intermediate markers (blood lipids and markers of inflammation). The effects of raloxifene, bazedoxifene and lasofoxifene on cardiovascular endpoint markers are presented as reported in recent, randomized, controlled trials. Raloxifene failed to significantly lower the risk of CAD in postmenopausal osteoporotic women, without any effect on stroke or early harm, but doubling the risk of venous thromboembolism. The risk of CAD wa...
Source: Climacteric - October 16, 2009 Category: Geriatrics Authors: de Villiers TJ Tags: Climacteric Source Type: journals

Local estrogens for quality of life and sexuality in postmenopausal women with cardiovascular disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Urogenital aging and female sexual dysfunction (FSD) are significant problems following menopause. Estrogen decline is one of the key factors contributing to sexual functioning because of its crucial role for genital arousal (vasocongestion and lubrication) and other domains of the sexual response. Several common medical conditions, including cardiovascular disease (CVD), may interfere with women's sexual response across the aging process. FSD is one of the most common CVD-related quality-of-life complications with a major impact on patients' and their sexual partners' life. There is no evidence that FSD may represent ...
Source: Climacteric - October 16, 2009 Category: Geriatrics Authors: Nappi RE, Albani F, Chiovato L, Polatti F Tags: Climacteric Source Type: journals

IMS Consensus Statements - 'What is their role?'.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19811228 [PubMed - in process] (Source: Climacteric)
Source: Climacteric - September 30, 2009 Category: Geriatrics Authors: Panay N, Fenton A Tags: Climacteric Source Type: journals

Aging, menopause, cardiovascular disease and HRT International Menopause Society Consensus Statement.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Authors: PMID: 19811229 [PubMed - in process] (Source: Climacteric)
Source: Climacteric - September 30, 2009 Category: Geriatrics Tags: Climacteric Source Type: journals

Acupuncture for hot flushes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Authors: PMID: 19811230 [PubMed - in process] (Source: Climacteric)
Source: Climacteric - September 30, 2009 Category: Geriatrics Tags: Climacteric Source Type: journals

Severity of menopausal symptoms of Jordanian women.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Introduction Menopause is a transitional period that every woman goes through if she lives beyond the age of 52 years. The health care of women during this stage requires special attention to the identification of their health needs in order to provide competent care. The aim of the study was to assess severity of symptoms related to the menopausal period and to describe the differences in severity of menopausal symptoms according to menopausal status. Methods and design A descriptive cross-sectional design was used. Data were collected from 350 Jordanian women using a self-administered questionnaire consisting of a so...
Source: Climacteric - September 2, 2009 Category: Geriatrics Authors: Gharaibeh M, Al-Obeisat S, Hattab J Tags: Climacteric Source Type: journals

Risk of hypoactive sexual desire disorder and associated factors in a cohort of oophorectomized women.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Nearly three out of four women who had undergone bilateral oophorectomy were at risk of suffering HSDD; this risk was increased when less than 5 years since surgical menopause had elapsed. The use of hormone replacement therapy was associated with lower HSDD risk. PMID: 19731121 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - September 1, 2009 Category: Geriatrics Authors: Castelo-Branco C, Palacios S, Combalia J, Ferrer M, Traveria G Tags: Climacteric Source Type: journals

Comparative effects of conventional hormone replacement therapy and tibolone on climacteric symptoms and sexual dysfunction in postmenopausal women.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion Tibolone may be an alternative to conventional hormone replacement therapy in the treatment of climacteric symptoms and sexual dysfunction in postmenopausal women. PMID: 19731119 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - August 31, 2009 Category: Geriatrics Authors: Ziaei S, Moghasemi M, Faghihzadeh S Tags: Climacteric Source Type: journals

Risk of gynecological cancers in users of estradiol/dydrogesterone or other HRT preparations.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion This study provides evidence that the risk of developing gynecological cancers with E/D use of several months to a few years is similar to the risks of developing gynecological cancer without HRT or use of other HRT. PMID: 19731120 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - August 31, 2009 Category: Geriatrics Authors: Schneider C, Jick SS, Meier CR Tags: Climacteric Source Type: journals

Age at menarche, age at menopause and duration of fertility as risk factors for osteoporosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions In postmenopausal females, the cumulative exposure to endogenous estrogens, measured as years of menstruation, seems to be a significant protective factor against the development of postmenopausal osteoporosis. Age at menopause between 40 and 45 years, but not age at menarche, correlated with low bone mineral density in postmenopausal females. PMID: 19731122 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - August 31, 2009 Category: Geriatrics Authors: Sioka C, Fotopoulos A, Georgiou A, Xourgia X, Papadopoulos A, Kalef-Ezra JA Tags: Climacteric Source Type: journals

Women's mid-life health experiences in urban UK: an international comparison.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Our data do not support the existence of a single menopausal syndrome. There appears to be dialectic between culture and biology. It can be argued that symptoms experienced during the menopausal transition arise through a complexity of factors, not simply declining levels of estrogen or ethnicity; geographic location, local culture and temporality are factors that also need to be taken into account. PMID: 19722117 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - August 30, 2009 Category: Geriatrics Authors: Ward T, Scheid V, Tuffrey V Tags: Climacteric Source Type: journals

Subjective cognitive complaints at menopause associated with declines in performance of verbal memory and attentional processes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion A link has been demonstrated between the subjective and objective aspects of cognitive function in association with the menopausal transition. It is suggested that greater recognition be given to cognitive symptoms as forming part of the constellation of menopause-related symptoms. PMID: 19722118 [PubMed - as supplied by publisher] (Source: Climacteric)
Source: Climacteric - August 30, 2009 Category: Geriatrics Authors: Schaafsma M, Homewood J, Taylor A Tags: Climacteric Source Type: journals