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Reporting clinical trials: Why one plus one does not equal twoEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
To the Editor: We read with interest Thiboutot et al's November 2008 report of safety and efficacy of a product containing clindamycin phosphate 1.2% and benzoyl peroxide 2.5% for treatment of acne. In the report, Thiboutot et al present combined data from two randomized controlled trials (RCTs) as if the two RCTs were in fact one large RCT. Unfortunately, such an approach is invalid. (Source: Journal of the American Academy of Dermatology)
Source: Journal of the American Academy of Dermatology - November 19, 2009 Category: Dermatology Authors: Kenneth A. Katz, Clara Y. Kim, Hywel C. Williams Tags: Notes & Comments Source Type: journals

Linezolid surveillance program results for 2008 (LEADER Program for 2008)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, linezolid activity sampled by the 5th year of this LEADER Program showed sustained potency and spectrum (99.64% susceptibility levels). The nonsusceptible strain isolation rates remained stable and the plasmid-mediated ribosomal-based resistance mechanism that emerged in Staphylococcus aureus and Staphylococcus epidermidis strains in 2007 showed no evidence of dissemination or increased prevalence. However, there was evidence of cfr persistence with the S. epidermidis strain. The LEADER Program continues to be an effective and sensitive surveillance tool to detect and monitor novel oxazolidinone resistance ...
Source: Diagnostic Microbiology and Infectious Disease - November 13, 2009 Category: Microbiology Authors: David J. Farrell, Rodrigo E. Mendes, James E. Ross, Ronald N. Jones Tags: Antimicrobial Susceptibility Studies Source Type: journals

Zyvox® Annual Appraisal of Potency and Spectrum program: linezolid surveillance program results for 2008Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, the activity of linezolid remained uniform and stable across the sampled geographic regions studied when compared to the 2006 to 2007 results. Documented LZD-R remains rare (only 0.13% overall but highest for CoNS [0.41%] and enterococci [0.69%]) among the 24 countries sampled for the 6 different pathogen groups. Rates of clindamycin resistance and the frequency of MRSA varied by geographic region and between nations; therefore, like oxazolidinones, it requires continued surveillance for changing resistance patterns. (Source: Diagnostic Microbiology and Infectious Disease)
Source: Diagnostic Microbiology and Infectious Disease - November 13, 2009 Category: Microbiology Authors: Ronald N. Jones, James E. Ross, Jan M. Bell, Uchino Utsuki, Ikeda Fumiaki, Intetsu Kobayashi, John D. Turnidge Tags: Antimicrobial Susceptibility Studies Source Type: journals

Molecular Epidemiology and Antimicrobial Resistance Mechanisms of Methicillin-Resistant Staphylococcus aureus Isolated from Bovine MilkEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The aim of this study was to identify methicillin-resistant Staphylococcus aureus (MRSA) strains gathered from 2002 to 2006 from milk samples in Aydin region in Turkey. Among 93 S. aureus strains isolated from bovine milk with mastitis, 16 were resistant to methicillin. Methicillin-resistant S. aureus strains were studied further for their staphylococcal cassette chromosome mec (SCCmec) types, pulsotypes, spa and MLST types, antimicrobial susceptibilities, mechanisms of resistance and presence of Panton[ndash]Valentine leucocidin (PVL) toxin gene. The MRSA strains were multi-drug resistant. The susceptibility rates to anti...
Source: Zoonoses and Public Health - November 13, 2009 Category: Infectious Diseases Authors: S. Türkyılmaz, S. Tekbıyık, E. Oryasin, B. Bozdogan Source Type: journals

A variant of the Southern German clone of methicillin-resistant Staphylococcus aureus is predominant in CroatiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clin Microbiol Infect The aim of the present study was to investigate the antibiotic susceptibility patterns and molecular epidemiology of clinical methicillin-resistant Staphylococcus aureus (MRSA) isolates recovered in 24 hospitals in 20 cities in Croatia from October to December 2004. A total of 1815 consecutive S. aureus isolates were recovered, 248 of which were MRSA. The MRSA isolates were analysed using spa typing, multilocus sequence typing and SCCmec typing. Furthermore, the presence of Panton[ndash]Valentine leukocidin (PVL) genes was determined as a genetic marker for community-associated MRSA. The MRSA prevalen...
Source: Clinical Microbiology and Infection - November 11, 2009 Category: Microbiology Authors: A. Budimir, R. H. Deurenberg, Z. Bo[scaron]njak, E. E. Stobberingh, H. Cetkovic, S. Kalenic Source Type: journals

Clinical efficacy of first- and second-line treatments for HIV-associated Pneumocystis jirovecii pneumonia: a tri-centre cohort studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Pentamidine was associated with a greater risk of death when used as first- and second-line therapy for HIV-associated PCP, and was associated with more treatment changes. Clindamycin/primaquine appeared superior to pentamidine as second-line therapy for PCP in patients failing or developing toxicity with trimethoprim/sulfamethoxazole. In patients failing first-line treatment with non-trimethoprim/sulfamethoxazole regimens, second-line therapy should be trimethoprim/sulfamethoxazole. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - November 10, 2009 Category: Microbiology Authors: Helweg-Larsen, J., Benfield, T., Atzori, C., Miller, R. F. Tags: Original research Source Type: journals

A fatal case of transfusion-transmitted babesiosis in the State of Delaware.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: We believe that this is the first reported case of transfusion-transmitted babesiosis in Delaware, a nonendemic state. Our case illustrates that clinicians should consider babesiosis in the differential diagnosis of immunocompromised patients who have fever and recent transfusion history, even in areas where babesiosis is not endemic. It also demonstrates the need for better preventive strategies including more sensitive, specific, and rapid blood donor screening tests to prevent transfusion-transmitted babesiosis. PMID: 19906041 [PubMed - as supplied by publisher] (Source: Transfusion)
Source: Transfusion - November 9, 2009 Category: Hematology Authors: Zhao Y, Love KR, Hall SW, Beardell FV Tags: Transfusion Source Type: journals

Twenty-five year epidemiology of invasive methicillin-resistant Staphylococcus aureus (MRSA) isolates recovered at a burn centerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study we, evaluate the changes in PFT and antimicrobial resistance epidemiology of invasive MRSA isolates over 25 years at a single burn unit. Isolates were tested by pulsed-field gel electrophoresis (PFGE), broth microdilution antimicrobial susceptibility testing, and PCR for the virulence factors Panton–Valentine leukocidin (PVL) and arginine catabolic mobile element (ACME), and the resistance marker staphylococcal chromosomal cassette mec (SCCmec). Forty isolates were screened, revealing stable vancomycin susceptibility MIC without changes over time but decreasing susceptibility to clindamycin and ciprofloxaci...
Source: Burns : Journal of the International Society for Burn Injuries - November 6, 2009 Category: Cosmetic Surgery Authors: Clinton K. Murray, Robert L. Holmes, Michael W. Ellis, Katrin Mende, Steven E. Wolf, Linda K. McDougal, Charles H. Guymon, Duane R. Hospenthal Tags: Articles Source Type: journals

CLINDAMAX (Clindamycin Phosphate) Cream [PHARMADERM. A Division Of Nycomed US Inc.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Nov 6, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - November 6, 2009 Category: Drugs & Pharmacology Source Type: organizations

Inducible clindamycin resistance inEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions : Clindamycin is kept as a reserve drug and is usually advocated in severe MRSA infections depending upon the antimicrobial susceptibility results. We have reported a higher incidence of iMLS B from both community (66.67%) as well as hospital (33.33%) setup. Therefore clinical microbiology laboratory should report inducible clindamycin resistance routinely. (Source: Journal of Postgraduate Medicine)
Source: Journal of Postgraduate Medicine - November 2, 2009 Category: Internal Medicine Source Type: journals

CLINDAMYCIN PHOSPHATEaerosol, Foam [Perrigo New York Inc]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Nov 2, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - November 2, 2009 Category: Drugs & Pharmacology Source Type: organizations

In vitro activity of cem-101 against streptococcus pneumoniae and streptococcus pyogenes with defined macrolide resistance mechanisms.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
IN VITRO ACTIVITY OF CEM-101 AGAINST STREPTOCOCCUS PNEUMONIAE AND STREPTOCOCCUS PYOGENES WITH DEFINED MACROLIDE RESISTANCE MECHANISMS. Antimicrob Agents Chemother. 2009 Nov 2; Authors: McGhee P, Clark C, Kosowska-Shick K, Nagai K, Dewasse B, Beachel L, Appelbaum PC CEM-101 had an MIC range against macrolide-susceptible pneumococci of 0.002-0.016 mug/ml and of 0.004-1 mug/ml against macrolide-resistant phenotypes. Only 3 strains with erm(B) +/- mef(A) had CEM-101 MICs of 1 mug/ml and 218/221 strains had CEM-101 MICs </=0.5 mug/ml. CEM-101 MICs were up to 4-fold lower than those of telithromycin against all st...
Source: Antimicrobial Agents and Chemotherapy - November 2, 2009 Category: Microbiology Authors: McGhee P, Clark C, Kosowska-Shick K, Nagai K, Dewasse B, Beachel L, Appelbaum PC Tags: Antimicrob Agents Chemother Source Type: journals

Pneumocystis pneumonia in childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary: Pneumocystis pneumonia (PCP) is a life-threatening infection in immunocompromised children with quantitative and qualitative defects in T lymphocytes. At risk are children with lymphoid malignancies, HIV infection, corticosteroid therapy, transplantation and primary immunodeficiency states. Diagnosis is established through direct examination or polymerase chain reaction (PCR) from respiratory secretions. Trimethoprim–sulphamethoxazole is used for initial therapy in most patients, while pentamidine, atovaquone, clindamycin plus primaquine, and dapsone plus trimethoprim are alternatives. Prophylaxis of high-risk p...
Source: Paediatric Respiratory Reviews - October 30, 2009 Category: Respiratory Medicine Authors: Vasilios Pyrgos, Shmuel Shoham, Emmanuel Roilides, Thomas J. Walsh Tags: Mini-symposium: Fungi and The Paediatric Lung Source Type: journals

Detection of new mutations conferring resistance to linezolid in glycopeptide-intermediate susceptibility Staphylococcus hominis subspecies hominis circulating in an intensive care unitEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report alerts to the possible appearance of clinical strains of methicillin-resistant staphylococci with intermediate resistance to glycopeptides, resistance to linezolid, and multiple resistance to other second-line antibiotics. Content Type Journal ArticleCategory ArticleDOI 10.1007/s10096-009-0823-4Authors A. Sorlozano, University of Granada Departamento de Microbiologia, Facultad de Medicina Avda de Madrid 11 18012 Granada SpainJ. Gutierrez, University of Granada Departamento de Microbiologia, Facultad de Medicina Avda de Madrid 11 18012 Granada SpainT. Martinez, San Cecilio University Hospital Service of Mi...
Source: European Journal of Clinical Microbiology & Infectious Diseases - October 30, 2009 Category: Microbiology Tags: European Journal of Clinical Microbiology & Infectious Diseases Source Type: journals

CLEOCIN PEDIATRIC (Clindamycin Palmitate Hydrochloride) Granule, For Solution [Pharmacia And Upjohn Company ]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Oct 27, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - October 27, 2009 Category: Drugs & Pharmacology Source Type: organizations

Prevalence of serotypes and antimicrobial resistance of invasive strains of pneumococcus in children: analysis of 9 years.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Penicillin resistance was detected in 9.9% of the strains, being predominant from 2004 to 2008. Twenty different pneumococcal serotypes were identified, and 71.9% of the serotypes were represented in the 7-valent conjugate vaccine (PN CRM7) currently available. PMID: 19859623 [PubMed - as supplied by publisher] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - October 26, 2009 Category: Pediatrics Authors: Mantese OC, de Paula A, Almeida VV, de Aguiar PA, Wolkers PC, Alvares JR, Almeida SC, Guerra ML, Brandileone MC Tags: J Pediatr (Rio J) Source Type: journals

Clindamycin-primaquine versus pentamidine for the second-line treatment of pneumocystis pneumoniaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract There are limited data on the efficacy of alternative regimens for treating patients with pneumocystis pneumonia (PCP). We compared the efficacy of clindamycin-primaquine (C-P) with that of pentamidine as a secondline treatment for PCP. Among 91 patients receiving trimethoprim-sulfamethoxazole (TMP-SMX) as a first-line treatment for PCP, 31 (34%) did not respond and 7 (8%) had adverse reactions. Fourteen patients received C-P and 9 received pentamidine as a second-line regimen because of treatment failure or an adverse reaction to TMP-SMX. The response rate of patients to C-P was higher than the res...
Source: Journal of Infection and Chemotherapy - October 24, 2009 Category: Infectious Diseases Tags: Journal of Infection and Chemotherapy Source Type: journals

Management of acne vulgaris: an evidence-based updateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This review summarizes clinically important findings from 3 systematic reviews, 1 updated guideline and a selection from the 62 randomized controlled trials (RCTs) published between February 2007 and January 2009 on the topic of acne vulgaris. Low glycaemic-load diets might reduce acne severity but this remains unproven. Written patient information leaflets have not been surpassed by other communication methods. New combination topical treatments have not shown convincing advantages over current combination products such as clindamycin/benzoyl peroxide. Topical dapsone is superior to placebo but has yet to be compared with...
Source: Clinical And Experimental Dermatology - October 22, 2009 Category: Dermatology Authors: J. R. Ingram, D. J. C. Grindlay, H. C. Williams Source Type: journals

Second-line salvage treatment of AIDS-associated Pneumocystis jirovecii pneumonia: a case series and systematic reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Source: DARE Area: Evidence > Disease Focused Reviews CRD Summary: The authors concluded that trimethoprim-sulfamethoxazole should be used as second-line treatment for patients with AIDS-associated Pneumocystis jirovecii pneumonia who fail first-line treatment with other regimens. The limited search, incomplete reporting of review methods, differences between studies and lack of direct comparisons between treatments meant that the authors' conclusions may not be reliable. [For second-line treatment most studies used pentamidine; other studies used trimethoprim-sulfamethoxazole (TMP-SMX), clindamycin-primaquine (C-P), or...
Source: NeLM - Respiratory Medicine - October 20, 2009 Category: Respiratory Medicine Source Type: organizations

New Study Assesses Skin Hydration and Epidermal Function of 2.5% and 5% Benzoyl Peroxide-Clindamycin CombinationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
clin-BPO 2.5% was superior in maintaining skin hydration than twice daily clin-BPO 5% clin-BPO 2.5% revealed no evidence of epidermal barrier impairment FT. WORTH, Texas--(BUSINESS WIRE)--Oct 20, 2009 - Dermatologists agree that topical... (Source: Drugs.com - Clinical Trials)
Source: Drugs.com - Clinical Trials - October 20, 2009 Category: Pharmaceuticals Source Type: clinical trials

CLINDAMYCIN PHOSPHATEcream [E. FOUGERA CO. A Division Of Nycomed US Inc.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Oct 20, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - October 20, 2009 Category: Drugs & Pharmacology Source Type: organizations

Perrigo Announces Dismissal of Duac(R) Patent LitigationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ALLEGAN, Mich., Oct. 19 (HSMN NewsFeed) -- Perrigo Company (Nasdaq: PRGO; TASE) announced today that the Hatch-Waxman litigation relating to Duac® Gel (clindamycin phosphate (1%) and benzoyl peroxide (5%) gel) filed by the Stiefel Laboratories divisi... Biopharmaceuticals, Generics, LitigationPerrigo, GlaxoSmithKline, Duac , clindamycin (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - October 19, 2009 Category: Pharmaceuticals Source Type: news

Acenocoumarol/clindamycin interaction: First report of an interaction, leading to spontaneous haematoma in an elderly patient: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - October 19, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

Continuous Clindamycin Infusion: an Innovative Approach to Treating Bone and Joint Infection.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Feasibility, safety and efficacy of prolonged, continuous, intravenous clindamycin therapy were retrospectively evaluated for 70 patients treated for bone and joint infections, 40% as outpatients. Median treatment duration was 40 days, median daily clindamycin dose was 2400 mg and 3 moderate-grade adverse events occurred. Median serum clindamycin concentrations on days 3-14 and 8-28 were 5 and 6.2 mg/liter, respectively; the median concentration was significantly lower (P<0.02) in patients treated with rifampin (5.3 mg/liter) versus without rifampin (8.9 mg/liter). Among 53 patients with a median [range] follow-up o...
Source: Antimicrobial Agents and Chemotherapy - October 18, 2009 Category: Microbiology Authors: Zeller V, Dzeing-Ella A, Kitzis MD, Ziza JM, Mamoudy P, Desplaces N Tags: Antimicrob Agents Chemother Source Type: journals

In vitro activity of mirincamycin (U24729A) in Plasmodium falciparum isolates from Gabon.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We assessed the in vitro activity of mirincamycin, a lincosamide antibiotic, against Plasmodium falciparum clinical isolates from Gabon. Growth was determined by HRP2-ELISA using an adapted protocol with prolonged incubation time (6 days) to account for antibiotic induced delayed death. Mirincamycin's cis and trans isomers are more active (median IC50: 3.2 nM and 2.6 nM) than the comparator drugs clindamycin (IC50: 12 nM) and doxycycline (IC50: 720 nM) and therefore further clinical development is promising. PMID: 19841147 [PubMed - as supplied by publisher] (Source: Antimicrobial Agents and Chemotherapy)
Source: Antimicrobial Agents and Chemotherapy - October 18, 2009 Category: Microbiology Authors: Held J, Westerman R, Kremsner PG, Mordmüller B Tags: Antimicrob Agents Chemother Source Type: journals

EVOCLIN (Clindamycin Phosphate) Aerosol, Foam [Stiefel Laboratories Inc]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Oct 14, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - October 14, 2009 Category: Drugs & Pharmacology Source Type: organizations

ACANYA (Clindamycin Phosphate And Benzoyl Peroxide) Kit [Dow Pharmaceuticals Sciences]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Oct 14, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - October 14, 2009 Category: Drugs & Pharmacology Source Type: organizations

New Study Assesses Skin Hydration And Epidermal Function Of 2.5% And 5% Benzoyl Peroxide-Clindamycin CombinationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Las Vegas, NV – October 15, 2009 – Dermatologists agree that topical fixed-combination products containing clindamycin (clin) and benzoyl peroxide (BPO) are effective in the treatment of acne. However, products containing BPO... (Source: Drugs.com - Clinical Trials)
Source: Drugs.com - Clinical Trials - October 13, 2009 Category: Pharmaceuticals Source Type: clinical trials

Flucloxacillin, still the empirical choice for putative Staphylococcus aureus infections in intensive care units in the NetherlandsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions The empirical choice of flucloxacillin in the case of putative S. aureus infections in patients admitted to ICUs in the Netherlands is still justified. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - October 12, 2009 Category: Microbiology Authors: Rijnders, M. I. A., Deurenberg, R. H., Boumans, M. L. L., Hoogkamp-Korstanje, J. A. A., Beisser, P. S., Stobberingh, E. E., on behalf of the Antibiotic Resistance Surveillance Group Tags: Original research Source Type: journals

CLINDAMAX (Clindamycin Phosphate) Gel [ PharmaDerm, A Division Of Nycomed US Inc.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Oct 9, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - October 9, 2009 Category: Drugs & Pharmacology Source Type: organizations

ZIANA (Clindamycin Phosphate And Tretinoin) Gel [Medicis Pharmaceutical Corp]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Oct 9, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - October 9, 2009 Category: Drugs & Pharmacology Source Type: organizations

Effects of Subinhibitory Concentrations of Antibiotics on Colonization Factor Expression by Moxifloxacin-Susceptible and Moxifloxacin-Resistant Clostridium difficile Strains.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objective of this study was to analyze expression of these genes in the same conditions in four NAP1/027 strains, one moxifloxacin-susceptible and three moxifloxacin-resistant strains. Two in vitro selected moxifloxacin-resistant mutants were also analyzed. Moxifloxacin resistance was associated to the Thr82-->Ile substitution in GyrA in all moxifloxacin-resistant strains but one. The expression of cwp84 and slpA was strongly increased after culture with ampicillin or clindamycin in NAP1/027 strains. Interestingly, after culture with fluoroquinolones, the expression of cwp84 and slpA was only increased in four moxif...
Source: Antimicrobial Agents and Chemotherapy - October 4, 2009 Category: Microbiology Authors: Denève C, Bouttier S, Dupuy B, Barbut F, Collignon A, Janoir C Tags: Antimicrob Agents Chemother Source Type: journals

Clindamycin-induced CovS-mediated regulation of the production of the virulent exoproteins streptolysin O, NAD glycohydrolase, and streptokinase in Streptococcus pyogenes.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The administration of high-dose clindamycin (CLI) along with penicillin is recommended for the treatment of streptococcal toxic shock syndrome. However, the prevalence of CLI-resistant Streptococcus pyogenes is increasing worldwide, and the effect of CLI on CLI-resistant S. pyogenes remains unknown. We aimed to evaluate the effect of CLI on the in vitro production of 3 major virulent exoproteins, namely, streptolysin O (Slo), NAD-glycohydrolase (Nga), and streptokinase (Ska), by CLI-resistant S. pyogenes. After incubation of M1 serotype CLI-resistant S. pyogenes D2TY in the presence of 1 mug/mL CLI, the amounts of Slo,...
Source: Antimicrobial Agents and Chemotherapy - October 4, 2009 Category: Microbiology Authors: Minami M, Kamimura T, Isaka M, Tatsuno I, Ohta M, Hasegawa T Tags: Antimicrob Agents Chemother Source Type: journals

[Stevens-Johnson syndrome plus intrahepatic cholestasis caused by clindamycin or chlorpheniramine]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a discussion of this case and review the main characteristics of the Stevens Johnson Syndrome. PMID: 19624990 [PubMed - indexed for MEDLINE] (Source: Dermatol Online J)
Source: Dermatol Online J - October 3, 2009 Category: Dermatology Authors: Sahagún Flores JE, Soto Ortiz JA, Tovar Méndez CE, Cárdenas Ochoa EC, Hernández Flores G Tags: Dermatol Online J Source Type: journals

Antibiograms and Molecular Subtypes of Methicillin-Resistant Staphylococcus aureus in Local Teaching Hospital, Malaysia.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, no vancomycin-resistant isolate was observed. The Malaysian MDR MRSA isolates were mostly SCCmec type III and negative for PVL. These strains were genetically distinct from the SCCmec type IV strains, which were sensitive to SXT, tetracycline, and erythromycin. Only two strains were SCCmec IV and PVL-positive. The infections in the hospital concerned were probably caused by multiple subtypes of MRSA. PMID: 19884790 [PubMed - in process] (Source: Journal of Microbiology and Biotechnology)
Source: Journal of Microbiology and Biotechnology - October 1, 2009 Category: Biotechnology Authors: Thong KL, Junnie J, Liew FY, Yusof MY, Hanifah YA Tags: J Microbiol Biotechnol Source Type: journals

Topical clindamycin in post-adenotonsillectomy analgesia in children: A double-blind, randomized clinical trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The use of topical clindamycin was beneficial in reducing pain on the first postoperative day, without effect on subsequent days. Future investigations could examine the use of topical clindamycin not only in the first 12 hours but also during five days of follow-up. (Source: Otolaryngology - Head and Neck Surgery)
Source: Otolaryngology - Head and Neck Surgery - September 28, 2009 Category: ENT & OMF Authors: Mauricio Schreiner Miura, Catia Saleh, Marina de Andrade, Melina Assmann, Lucélia Hernandes Lima, José Faibes Lubianca Neto Tags: Pediatric Otolaryngology Source Type: journals

Idiopathic pustular vulvitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 31-year-old woman presented in the 23rd week of her third pregnancy with extremely painful pustular vulvitis, unresponsive to antibiotics. Although the histological findings were was consistent with a diagnosis of hidradenitis suppurativa (HS), bridged comedones, the hallmark of this disease, were absent and there were no dermal sinuses. Incision and drainage of the pustules provided only temporary improvement, which was briefly maintained with oral clindamycin and topical steroids. After the birth, a course of isotretinoin produced almost total clearance, a response not typically found in HS. This patient's condition ma...
Source: Clinical And Experimental Dermatology - September 21, 2009 Category: Dermatology Authors: M. Dhanjal, F. Teixeira, O. Dadzie, G. Rose Source Type: journals

Perrigo Acquires ANDA for Generic Version Duac(R) Gel From KV PharmaceuticalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
ALLEGAN, Mich., Sept. 21 (HSMN NewsFeed) -- Perrigo Company (Nasdaq: PRGO;TASE) today announced that it has purchased the ANDA for clindamycin phosphate (1%) and benzoyl peroxide (5%) gel from KV Pharmaceutical for $14 million in cash at closing and a $2... Biopharmaceuticals, Generics, Dermatology, AcquisitionsPerrigo, KV Pharmaceutical, clindamycin, benzoyl peroxide (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - September 21, 2009 Category: Pharmaceuticals Source Type: news

Perrigo Acquires ANDA For Generic Version Duac® Gel From KV PharmaceuticalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Perrigo Company (Nasdaq: PRGO;TASE) today announced that it has purchased the ANDA for clindamycin phosphate (1%) and benzoyl peroxide (5%) gel from KV Pharmaceutical for $14 million in cash at closing and a $2 million milestone payment upon the completion of a successful technical transfer. (Source: Pharmaceutical Online News)
Source: Pharmaceutical Online News - September 21, 2009 Category: Pharmaceuticals Source Type: news

Efficacy of antibiotic therapy for SAPHO syndrome is lost after its discontinuation: interventional studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: For the period of application, the antibiotic therapy seems to have controlled the disease. After antibiotics discontinuation however, disease relapse was observed. SAPHO syndrome thus groups with other chronic inflammatory arthropathies with a need of permanent therapy. (Source: Arthritis Research and Therapy)
Source: Arthritis Research and Therapy - September 20, 2009 Category: Rheumatology Authors: Gunter AssmannOlaf KueckTimm KirchhoffHerbert RosenthalJan VoswinkelMichael PfreundschuhHenning ZeidlerAnnette Wagner Source Type: journals

OBSERVATION: Interaction of Topical Sulfacetamide and Topical Dapsone With Benzoyl PeroxideEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Knowledge of the chemical reaction between benzoyl peroxide and sulfacetamide and dapsone will help minimize the occurrence of this interaction on our patients' skin. (Source: Archives of Dermatology)
Source: Archives of Dermatology - September 20, 2009 Category: Dermatology Authors: Dubina, M. I., Fleischer, A. B. Tags: Dermatology, Dermatologic Disorders, Acne, Dermatologic Disorders, Other, Drug Therapy, Adverse Effects Observation Source Type: journals

Varied Prevalence of Clostridium difficile in an Integrated Swine Operation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The objectives of this study were to compare the prevalence of Clostridium difficile (Cd) among different age and production groups of swine in a vertically integrated swine operation in Texas in 2006 and to compare our isolates to other animal and human isolates. Results are based on 131 Cd isolates from 1008 swine fecal samples and pork trim samples (overall prevalence of 13%). The prevalence (number positive/number tested in production type) of Cd was different between the groups (P</=0.001), and was highest among suckling piglets at 50.0% (61/122), followed by 23.8% (34/143) for lactating sows and effluent from the ...
Source: Anaerobe - September 20, 2009 Category: Microbiology Authors: Norman KN, Harvey RB, Scott HM, Hume ME, Andrews K, Brawley AD Tags: Anaerobe Source Type: journals

Cost analysis and antimicrobial susceptibility testing comparing the E test and the agar dilution method in Campylobacter jejuni and Campylobacter coliEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Although numerous reports have compared the antimicrobial susceptibility of Campylobacter spp., controversy still exists about the use of the E test as an alternative to the agar dilution method suggested by the Clinical and Laboratory Standards Institute. MICs of 8 antimicrobials were determined using the E test and agar dilution methods for 103 Campylobacter jejuni and Campylobacter coli isolates from fresh chicken randomly purchased from stores in 3 southern Ontario counties. Overall, 72.6% of E test MIC values were within 1 log2 dilution and 95.7% within 2 log2 dilutions of the corresponding agar dilution MIC...
Source: Diagnostic Microbiology and Infectious Disease - September 14, 2009 Category: Microbiology Authors: Alfonso Valdivieso-García, Ryan Imgrund, Anne Deckert, Betsy Marie Varughese, Kathleen Harris, Natalie Bunimov, Richard Reid-Smith, Scott McEwen Tags: Antimicrobial Susceptibility Studies Source Type: journals

Isolation and characterization of methicillin-resistant Staphylococcus aureus from swine and workers in ChinaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions MRSA from Chinese pigs and farm workers (ST9) differed from the European pig-associated clone (ST398) with regard to clonal type, SCCmec content and resistance profile. (Source: Journal of Antimicrobial Chemotherapy)
Source: Journal of Antimicrobial Chemotherapy - September 8, 2009 Category: Microbiology Authors: Cui, S., Li, J., Hu, C., Jin, S., Li, F., Guo, Y., Ran, L., Ma, Y. Tags: Original research Source Type: journals

Inappropriate use of vancomycin for preventing perinatal group B streptococcal (GBS) disease in laboring patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Journal of Perinatal Medicine 37 (5): 487-489 Abstract Objective: The 2002 CDC guidelines for the prevention of perinatal group B streptococcus (GBS) stipulate that vancomycin is reserved for penicillin-allergic women at high risk for beta-lactam anaphylaxis with resistance to clindamycin or erythromycin. Our objective was to evaluate practitioner adherence to these guidelines. Methods: This is a retrospective chart review of patients admitted to labor and delivery who received vancomycin for GBS prophylaxis from January 1st, 2005 to June 1st, 2007. Identification and documentation of allergic reactions to beta lactams and...
Source: Journal of Perinatal Medicine - September 3, 2009 Category: Perinatology & Neonatology Source Type: journals

Healthy People Taking Antibiotics May Spread Superbug InfectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present these findings in protest of the way in which they were acquired.Reference: Lawley T D et al. "Antibiotic treatment of Clostridium difficile carrier mice triggers a supershedder state, transmission, and severe disease in immunocompromised hosts." Infection and Immunity. Published ahead of print, doi:10.1128/IAI.00558-09. For more information: http://www.sanger.ac.uk/Info/Press/2009/090721.shtml http://www.cdc.gov/ncidod/dhqp/id_CdiffFAQ_general.html http://www.mayoclinic.com/health/c-difficile/DS00736 (Source: NaturalNews.com)
Source: NaturalNews.com - September 3, 2009 Category: Consumer Health Advice Source Type: news

CLINDAMAX LOTION (Clindamycin Phosphate) Suspension [PharmaDerm, A Division Of Nycomed US Inc.]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Sep 2, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - September 2, 2009 Category: Drugs & Pharmacology Source Type: organizations

New susceptibility breakpoints in antimicrobial resistance rates of invasive pneumococcal strains.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: When the new breakpoints for in vitro susceptibility were applied, penicillin resistance rates dropped 97%, from 33 to 1%. PMID: 19830357 [PubMed - in process] (Source: Jornal de Pediatria)
Source: Jornal de Pediatria - August 31, 2009 Category: Pediatrics Authors: Wolkers PC, Mantese OC, de Paula A, Almeida VV, de Aguiar PA, Alvares JR, Almeida SC, Brandileone MC Tags: J Pediatr (Rio J) Source Type: journals

Clindamycin: Drug hypersensitivity: case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Reactions)
Source: Reactions - August 31, 2009 Category: Drugs & Pharmacology Tags: Short communication Source Type: journals

CLINDAMYCIN HYDROCHLORIDEcapsule [Aurobindo Pharma Limited]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Updated Date: Aug 31, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))
Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST) - August 31, 2009 Category: Drugs & Pharmacology Source Type: organizations