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Unveiling the Right Side: Seashells from the Collection of Thomas Annesley [Clinical Chemist]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical Chemistry)
Source: Clinical Chemistry - October 28, 2009 Category: Chemistry Authors: Annesley, T. Tags: Clinical Chemist Source Type: journals

What Is Your Guess? Hyperkalemia or Hypokalemia? [Clinical Chemist]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical Chemistry)
Source: Clinical Chemistry - October 28, 2009 Category: Chemistry Authors: Yu, H.-Y. E., Kellogg, M. Tags: Clinical Chemist Source Type: journals

Seashells from the Collection of Thomas Annesley [Unveiling the Right Side]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical Chemistry)
Source: Clinical Chemistry - October 28, 2009 Category: Chemistry Authors: Annesley, T. Tags: Unveiling the Right Side Source Type: journals

Hyperkalemia or Hypokalemia? [What Is Your Guess?]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical Chemistry)
Source: Clinical Chemistry - October 28, 2009 Category: Chemistry Authors: Yu, H.-Y. E., Kellogg, M. Tags: What Is Your Guess? Source Type: journals

Lily Robinson and an Assassin's Tracks [Clinical Chemist]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical Chemistry)
Source: Clinical Chemistry - October 28, 2009 Category: Chemistry Tags: Clinical Chemist Source Type: journals

Clinical Chemistry's NIH Book Club Corner, NIH Biomedical Computing Interest Group Book Club Review of How Doctors Think by Jerome Groopman. Jim DeLeo, Alan T. Remaley, G. William Moore, Gerald L. McLaughlin, Ellen J. Bicknell, and Melanie Swan. [Book, Software, and Website Reviews]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical Chemistry)
Source: Clinical Chemistry - October 28, 2009 Category: Chemistry Authors: DeLeo, J., Remaley, A. T., Moore, G. W., McLaughlin, G. L., Bicknell, E. J., Swan, M. Tags: Book, Software, and Website Reviews Source Type: journals

In Reply [Letters to the Editor]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical Chemistry)
Source: Clinical Chemistry - October 28, 2009 Category: Chemistry Authors: Ishigami, M. Tags: Letters to the Editor Source Type: journals

Limitations of Automated Remnant Lipoprotein Cholesterol Assay for Diagnostic Use [Letters to the Editor]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical Chemistry)
Source: Clinical Chemistry - October 28, 2009 Category: Chemistry Authors: Schaefer, E. J. Tags: Letters to the Editor Source Type: journals

RET Mutation Scanning Update: Exon 15 [Letters to the Editor]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical Chemistry)
Source: Clinical Chemistry - October 28, 2009 Category: Chemistry Authors: Margraf, R. L., Calderon, F. R.O., Mao, R., Wittwer, C. T. Tags: Letters to the Editor Source Type: journals

Short- and Long-Term Cardiac Troponin I Analyte Stability in Plasma and Serum from Healthy Volunteers by Use of an Ultrasensitive, Single-Molecule Counting Assay [Letters to the Editor]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical Chemistry)
Source: Clinical Chemistry - October 28, 2009 Category: Chemistry Authors: Wu, A. H.B., Shea, E., Lu, Q. T., Minyard, J., Bui, K., Hsu, J. C.Y., Agee, S. J., Todd, J. Tags: Letters to the Editor Source Type: journals

Removal of Inhibitory Effects in a Serum Cardiac Troponin I Immunoassay [Letters to the Editor]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical Chemistry)
Source: Clinical Chemistry - October 28, 2009 Category: Chemistry Authors: Wang, L., Bunk, D. M., He, H.-J., Cole, K. D. Tags: Letters to the Editor Source Type: journals

Forty-Five-Year Evolution of Stat Blood and Plasma Lactate Measurement to Guide Critical Care [Citation Classic]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical Chemistry)
Source: Clinical Chemistry - October 28, 2009 Category: Chemistry Authors: Weil, M. H., Tang, W. Tags: Citation Classic Source Type: journals

Plasma Proprotein Convertase Subtilisin/Kexin Type 9: A Marker of LDL Apolipoprotein B-100 Catabolism? [Brief Communication]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In men, variation in plasma PCSK9 concentration influences the catabolism of LDL apo B-100. This finding appears to be independent of obesity, insulin resistance, energy intake, and age. (Source: Clinical Chemistry)
Source: Clinical Chemistry - October 28, 2009 Category: Chemistry Authors: Chan, D. C., Lambert, G., Barrett, P. H. R., Rye, K.-A., Ooi, E. M.M., Watts, G. F. Tags: Brief Communication Source Type: journals

Urotensin II Immunoreactivity in the Human Circulation: Evidence for Widespread Tissue Release [Endocrinology and Metabolism]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: UII is secreted from the heart and multiple other tissues into the circulation. Related increments in UII immunoreactivity across multiple tissue sites suggest that peptide release occurs via a shared mechanism. Increased UII immunoreactivity is observed in subjects with acute coronary syndrome. (Source: Clinical Chemistry)
Source: Clinical Chemistry - October 28, 2009 Category: Chemistry Authors: Chen, Y.-H., Yandle, T. G., Richards, A. M., Palmer, S. C. Tags: Endocrinology and Metabolism Source Type: journals

Stability and Reproducibility of a Single-Sample Urinary C-Peptide/Creatinine Ratio and Its Correlation with 24-h Urinary C-Peptide [Endocrinology and Metabolism]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Second-void fasting UCPCR is a reproducible measure that correlates well with 24-h UCP in normal samples. The 3-day stability of UCPCR at room temperature greatly increases its potential clinical utility. (Source: Clinical Chemistry)
Source: Clinical Chemistry - October 28, 2009 Category: Chemistry Authors: McDonald, T. J., Knight, B. A., Shields, B. M., Bowman, P., Salzmann, M. B., Hattersley, A. T. Tags: Endocrinology and Metabolism Source Type: journals

Plasma Uric Acid and Hypertension in a Chinese Community: Prospective Study and Metaanalysis [Endocrinology and Metabolism]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These data suggest a positive association between plasma uric acid and incidence of hypertension during short-term follow-up in a Chinese population. The association between hyperuricemia and hypertension was partly mediated by abdominal obesity. (Source: Clinical Chemistry)
Source: Clinical Chemistry - October 28, 2009 Category: Chemistry Authors: Zhang, W., Sun, K., Yang, Y., Zhang, H., Hu, F. B., Hui, R. Tags: Endocrinology and Metabolism Source Type: journals

Composite Reference Interval for Thyroid-Stimulating Hormone and Free Thyroxine, Comparison with Common Cutoff Values, and Reconsideration of Subclinical Thyroid Disease [Endocrinology and Metabolism]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Conventional application of separate cutoff values for FT4 and TSH leads to overestimation of the incidence of subclinical thyroid disease. Application of a composite overall reference interval is recommended. (Source: Clinical Chemistry)
Source: Clinical Chemistry - October 28, 2009 Category: Chemistry Authors: Ross, H. A., den Heijer, M., Hermus, A. R.M.M., Sweep, F. C.G.J. Tags: Endocrinology and Metabolism Source Type: journals

Simultaneous Screening and Quantification of 29 Drugs of Abuse in Oral Fluid by Solid-Phase Extraction and Ultraperformance LC-MS/MS [Drug Monitoring and Toxicology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The UPLC-MS/MS method makes it possible to detect all 29 analytes in 1 chromatographic run (15 min), including -9-tetrahydrocannabinol and benzoylecgonine, which previously have been difficult to incorporate into multicomponent methods. (Source: Clinical Chemistry)
Source: Clinical Chemistry - October 28, 2009 Category: Chemistry Authors: Badawi, N., Simonsen, K. W., Steentoft, A., Bernhoft, I. M., Linnet, K. Tags: Drug Monitoring and Toxicology Source Type: journals

A High-Sensitivity, Medium-Density, and Target Amplification-Free Planar Waveguide Microarray System for Gene Expression Analysis of Formalin-Fixed and Paraffin-Embedded Tissue [Automation and Analytical Techniques]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The presented PWG platform demonstrated excellent sensitivity and precision and is especially well suited for any application for which fast, simple, and robust multiplex assays of RNA in FFPE tissue are required. (Source: Clinical Chemistry)
Source: Clinical Chemistry - October 28, 2009 Category: Chemistry Authors: Schwers, S., Reifenberger, E., Gehrmann, M., Izmailov, A., Bohmann, K. Tags: Automation and Analytical Techniques Source Type: journals

Comparison of Urinary Albumin Quantification by Immunoturbidimetry, Competitive Immunoassay, and Protein-Cleavage Liquid Chromatography-Tandem Mass Spectrometry [Proteomics and Protein Markers]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results showed a reasonable quantification of urinary albumin by representative polyclonal and monoclonal immunoassays compared to an LC-MS/MS assay. In addition, the results do not suggest the presence of nonimmunoreactive albumin in urine. However, differences in analytic performance between assays support the need for a reference calibration material and reference method to standardize clinical laboratory measurements of urinary albumin. (Source: Clinical Chemistry)
Source: Clinical Chemistry - October 28, 2009 Category: Chemistry Authors: Seegmiller, J. C., Sviridov, D., Larson, T. S., Borland, T. M., Hortin, G. L., Lieske, J. C. Tags: Proteomics and Protein Markers Source Type: journals

Fully Traceable Absolute Protein Quantification of Somatropin That Allows Independent Comparison of Somatropin Standards [Proteomics and Protein Markers]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: An independent method that does not rely on a preexisting protein standard has been developed and validated for the traceable value-assignment of total somatropin. The methods reported here address the amount of substance (mass fraction) of the standard materials but address neither biological activity nor other characteristics that may be important in assessing suitability for use as a calibrator. (Source: Clinical Chemistry)
Source: Clinical Chemistry - October 28, 2009 Category: Chemistry Authors: Pritchard, C., Quaglia, M., Mussell, C., Burkitt, W. I., Parkes, H., O'Connor, G. Tags: Proteomics and Protein Markers Source Type: journals

Plasma MicroRNAs as Sensitive and Specific Biomarkers of Tissue Injury [Molecular Diagnostics and Genetics]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results demonstrate that tissue-specific miRNAs may serve as diagnostically sensitive plasma biomarkers of tissue injury. (Source: Clinical Chemistry)
Source: Clinical Chemistry - October 28, 2009 Category: Chemistry Authors: Laterza, O. F., Lim, L., Garrett-Engele, P. W., Vlasakova, K., Muniappa, N., Tanaka, W. K., Johnson, J. M., Sina, J. F., Fare, T. L., Sistare, F. D., Glaab, W. E. Tags: Molecular Diagnostics and Genetics Source Type: journals

Presence and Characterization of Cell-Free Seminal RNA in Healthy Individuals: Implications for Noninvasive Disease Diagnosis and Gene Expression Studies of the Male Reproductive System [Molecular Diagnostics and Genetics]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Although cfsRNA was partially degraded, it represented diverse transcript species and was abundant, fairly stable, and associated with particles in healthy individuals. cfsRNA may represent a potential noninvasive biomarker of the male reproductive system and of germline epigenetics. (Source: Clinical Chemistry)
Source: Clinical Chemistry - October 28, 2009 Category: Chemistry Authors: Huang, S., Li, H., Ding, X., Xiong, C. Tags: Molecular Diagnostics and Genetics Source Type: journals

Cell-Free DNA as a Noninvasive Acute Rejection Marker in Renal Transplantation [Molecular Diagnostics and Genetics]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Given that renal biopsy is the gold standard for detecting AR, analysis of both plasma tCF-DNA and PCT could permit a more selective use of this invasive procedure. (Source: Clinical Chemistry)
Source: Clinical Chemistry - October 28, 2009 Category: Chemistry Authors: Garcia Moreira, V., Prieto Garcia, B., Baltar Martin, J. M., Ortega Suarez, F., Alvarez, F. V. Tags: Molecular Diagnostics and Genetics Source Type: journals

Genotyping for NOD2 Genetic Variants and Crohn Disease: a Metaanalysis [Molecular Diagnostics and Genetics]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The per-allele risk of Crohn disease was markedly higher for Leu1007fsinsC than for Arg702Trp and Gly908Arg. Combining all genotypes revealed the risks of Crohn disease for compound heterozygotes and homozygotes to be similar and markedly higher than for simple heterozygotes. (Source: Clinical Chemistry)
Source: Clinical Chemistry - October 28, 2009 Category: Chemistry Authors: Yazdanyar, S., Weischer, M., Nordestgaard, B. G. Tags: Molecular Diagnostics and Genetics Source Type: journals

Plasma miR-208 as a Biomarker of Myocardial Injury [Molecular Diagnostics and Genetics]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The plasma concentration of miR-208 may be a useful indicator of myocardial injury. Our results suggest that profiling of circulating miRNAs may help identify promising biomarkers of various pathologic conditions. (Source: Clinical Chemistry)
Source: Clinical Chemistry - October 28, 2009 Category: Chemistry Authors: Ji, X., Takahashi, R., Hiura, Y., Hirokawa, G., Fukushima, Y., Iwai, N. Tags: Molecular Diagnostics and Genetics Source Type: journals

Cystatin C and Cardiovascular Risk [Reviews]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report presents a review of the role of cystatin C as a predictor of cardiovascular risk. Summary: Patients with higher circulating cystatin C concentrations appear to have an increased cardiovascular risk profile, i.e., they are older and have a higher prevalence of systemic hypertension, dyslipidemia, documented CVD, increased body mass index, and increased concentrations of C-reactive protein. Prospective studies have shown, in various clinical scenarios, that patients with increased cystatin C are at a higher risk of developing both CVD and CKD. Importantly, cystatin C appears to be a useful marker for identifying...
Source: Clinical Chemistry - October 28, 2009 Category: Chemistry Authors: Taglieri, N., Koenig, W., Kaski, J. C. Tags: Reviews Source Type: journals

Oral Fluid Testing for Drugs of Abuse [Reviews]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Background: Oral fluid (OF) is an exciting alternative matrix for monitoring drugs of abuse in workplace, clinical toxicology, criminal justice, and driving under the influence of drugs (DUID) programs. During the last 5 years, scientific and technological advances in OF collection, point-of-collection testing devices, and screening and confirmation methods were achieved. Guidelines were proposed for workplace OF testing by the Substance Abuse and Mental Health Services Administration, DUID testing by the European Union’s Driving under the Influence of Drugs, Alcohol and Medicines (DRUID) program, and standardization...
Source: Clinical Chemistry - October 28, 2009 Category: Chemistry Authors: Bosker, W. M., Huestis, M. A. Tags: Reviews Source Type: journals

Commentary [Commentaries]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical Chemistry)
Source: Clinical Chemistry - October 28, 2009 Category: Chemistry Authors: Richardson, R. Tags: Commentaries Source Type: journals

Severe Hyponatremia with High Urine Sodium and Osmolality [Clinical Case Study]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical Chemistry)
Source: Clinical Chemistry - October 28, 2009 Category: Chemistry Authors: van der Hoek, J., Hoorn, E. J., de Jong, G. M.T., Janssens, E. N.W., de Herder, W. W. Tags: Clinical Case Study Source Type: journals

Clinical Assays for Human Chorionic Gonadotropin:: What Should We Measure and How? [Q[amp ]A]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical Chemistry)
Source: Clinical Chemistry - October 28, 2009 Category: Chemistry Authors: Gronowski, A. M. Tags: Q[amp ]A Source Type: journals

MicroRNAs as Novel Myocardial Biomarkers [Editorials]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical Chemistry)
Source: Clinical Chemistry - October 28, 2009 Category: Chemistry Authors: Margulies, K. B. Tags: Editorials Source Type: journals

The Special Sticky Hemoglobin [Unveiling the Right Side]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical Chemistry)
Source: Clinical Chemistry - September 27, 2009 Category: Chemistry Authors: Anand, U. Tags: Unveiling the Right Side Source Type: journals

The Case of a Bow Legged Toddler [What Is Your Guess?]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical Chemistry)
Source: Clinical Chemistry - September 27, 2009 Category: Chemistry Authors: Tatsas, A. D., Woodworth, A. Tags: What Is Your Guess? Source Type: journals

Kudos to Chad Mirkin [Clinical Chemist]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical Chemistry)
Source: Clinical Chemistry - September 27, 2009 Category: Chemistry Tags: Clinical Chemist Source Type: journals

Lily Robinson and an Assassin's Tracks [Clinical Chemist]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical Chemistry)
Source: Clinical Chemistry - September 27, 2009 Category: Chemistry Tags: Clinical Chemist Source Type: journals

POSTER ABSTRACTS 41st Annual [Oak Ridge Abstracts]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical Chemistry)
Source: Clinical Chemistry - September 27, 2009 Category: Chemistry Tags: Oak Ridge Abstracts Source Type: journals

Increased Plasma Lipoprotein(a) Found in Large-Artery Atherosclerotic, but Not Small-Artery Occlusive, Stroke [Letters to the Editor]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical Chemistry)
Source: Clinical Chemistry - September 27, 2009 Category: Chemistry Authors: Jones, G. T., Deng, M., Hammond-Tooke, G. D., McCormick, S. P. A., van Rij, A. M. Tags: Letters to the Editor Source Type: journals

Use of Likelihood Ratios Can Improve the Clinical Usefulness of Enzyme Immunoassays for the Diagnosis of Small-Vessel Vasculitis [Letters to the Editor]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical Chemistry)
Source: Clinical Chemistry - September 27, 2009 Category: Chemistry Authors: Vermeersch, P., Blockmans, D., Bossuyt, X. Tags: Letters to the Editor Source Type: journals

False-Negative Results from Point-of-Care Qualitative Human Chorionic Gonadotropin (hCG) Devices Caused by Excess hCG{beta} Core Fragment Vary with Device Lot Number [Letters to the Editor]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical Chemistry)
Source: Clinical Chemistry - September 27, 2009 Category: Chemistry Authors: Gronowski, A. M., Powers, M., Stenman, U. H., Ashby, L., Scott, M. G. Tags: Letters to the Editor Source Type: journals

Nonylphenol Ethoxylate Plastic Additives Inhibit Mitochondrial Respiratory Chain Complex I [Letters to the Editor]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical Chemistry)
Source: Clinical Chemistry - September 27, 2009 Category: Chemistry Authors: Belaiche, C., Holt, A., Saada, A. Tags: Letters to the Editor Source Type: journals

Simple and Reliable Measurement of Nitric Oxide Metabolites in Plasma [Citation Classic]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical Chemistry)
Source: Clinical Chemistry - September 27, 2009 Category: Chemistry Authors: Moshage, H. Tags: Citation Classic Source Type: journals

Proficiency Testing of Hb A1c: A 4-Year Experience in Taiwan and the Asian Pacific Region [Brief Communication]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The use of accuracy-based proficiency testing with stringent quality criteria has improved the performance of Hb A1c testing in the Asian and Pacific laboratories during the 4 years of assessment. (Source: Clinical Chemistry)
Source: Clinical Chemistry - September 27, 2009 Category: Chemistry Authors: Shiesh, S.-C., Wiedmeyer, H.-M., Kao, J.-T., Vasikaran, S. D., Lopez, J. B., the Laboratory Management Committee for the Asian-Pacific Federation of Clinical Biochemistry Tags: Brief Communication Source Type: journals

Pediatric Brain Natriuretic Peptide Concentrations Vary with Age and Sex and Appear to Be Modulated by Testosterone [Pediatric Clinical Chemistry]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In pediatric patients, NT-proBNP is independently associated with both testosterone and SHBG hormone concentrations. Measurements of testosterone are inversely associated with NT-proBNP, and estrogens are marginally associated with NT-proBNP in males but not females, suggesting that androgens and not estrogens modulate sex differences notable in natriuretic peptides. Children and adolescents may require an objective assessment of hormones if optimal interpretation of natriuretic peptide concentrations is desired or the concentrations are confounded. . (Source: Clinical Chemistry)
Source: Clinical Chemistry - September 27, 2009 Category: Chemistry Authors: Saenger, A. K., Dalenberg, D. A., Bryant, S. C., Grebe, S. K., Jaffe, A. S. Tags: Pediatric Clinical Chemistry Source Type: journals

Interactive Modeling for Ongoing Utility of Pharmacogenetic Diagnostic Testing: Application for Warfarin Therapy [Hemostasis and Thrombosis]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The target interval of plasma S-warfarin concentration required to yield a therapeutic INR can be predicted from the VKORC1 genotype (pharmacodynamics), and the progressive changes in S-warfarin concentration after repeated daily dosing can be predicted from the CYP2C9 genotype (pharmacokinetics). Combining the application of multivariate equations for estimating the maintenance dose with genotype-guided pharmacokinetics/pharmacodynamics modeling provides a powerful tool for maximizing the value of CYP2C9 and VKORC1 test results for ongoing application to patient care. (Source: Clinical Chemistry)
Source: Clinical Chemistry - September 27, 2009 Category: Chemistry Authors: Linder, M. W., Bon Homme, M., Reynolds, K. K., Gage, B. F., Eby, C., Silvestrov, N., Valdes, R. Tags: Hemostasis and Thrombosis Source Type: journals

Methylation Status and Neurodegenerative Markers in Parkinson Disease [General Clinical Chemistry]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Markers of neurodegeneration (APP, -synuclein) are related to markers of methylation (SAM, SAH) in patients with PD. Better cognitive function was related to higher methylation potential (SAM/SAH ratio). (Source: Clinical Chemistry)
Source: Clinical Chemistry - September 27, 2009 Category: Chemistry Authors: Obeid, R., Schadt, A., Dillmann, U., Kostopoulos, P., Fassbender, K., Herrmann, W. Tags: General Clinical Chemistry Source Type: journals

New ELISA for B Cell-Activating Factor [Clinical Immunology]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This new ELISA helped provide insights into why serum concentrations of BAFF vary between studies for a given population of patients. It is a reliable tool for the management of the diseases in which BAFF is an indication of response to therapy. (Source: Clinical Chemistry)
Source: Clinical Chemistry - September 27, 2009 Category: Chemistry Authors: Le Pottier, L., Bendaoud, B., Renaudineau, Y., Youinou, P., Pers, J.-O., Daridon, C. Tags: Clinical Immunology Source Type: journals

Increased Tissue Factor Expression Is Associated with Reduced Survival in Non-Small Cell Lung Cancer and with Mutations of TP53 and PTEN [Cancer Diagnostics]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results provide clear evidence that combined oncogene events affecting TSG dramatically increase TF gene expression in lung tumors. Moreover, this study suggests that TF gene expression could be used as a prognostic marker in NSCLC. . (Source: Clinical Chemistry)
Source: Clinical Chemistry - September 27, 2009 Category: Chemistry Authors: Regina, S., Valentin, J.-B., Lachot, S., Lemarie, E., Rollin, J., Gruel, Y. Tags: Cancer Diagnostics Source Type: journals

Measurement of Ribosomal RNA Turnover In Vivo by Use of Deuterium-Labeled Glucose [Automation and Analytical Techniques]Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our study results demonstrate the proof-of-principle that deuterium-labeled glucose may be used to analyze RNA turnover, in addition to DNA production/cell proliferation, in clinical samples. (Source: Clinical Chemistry)
Source: Clinical Chemistry - September 27, 2009 Category: Chemistry Authors: Defoiche, J., Zhang, Y., Lagneaux, L., Pettengell, R., Hegedus, A., Willems, L., Macallan, D. C. Tags: Automation and Analytical Techniques Source Type: journals