Clinical Chemistry and Laboratory MedicineThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

Read news and analysis about clinical lab software and the clinical lab industry at the most widely read lab blog - Lab Soft News.

• Contents
• Discussions

Pages: 1  2  3  4  5  6  7  8  9  10  11  12  13  14  

GSTP1*B allele increases the risk for asthma in childrenEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical Chemistry and Laboratory Medicine 47 (11): 1451-1453 (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - November 16, 2009 Category: Laboratory Medicine Source Type: journals

Quick and easy colorimetric test for calibration control of liquid handling workstationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical Chemistry and Laboratory Medicine 47 (11): 1447-1449 (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - November 16, 2009 Category: Laboratory Medicine Source Type: journals

Hypoxia related growth factors and p53 in preoperative sera from patients with colorectal cancer – evaluation of the prognostic significance of these agentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical Chemistry and Laboratory Medicine 47 (11): 1439-1445 Abstract Background: Insulin-like growth factor-I (IGF-I) and vascular endothelial growth factor (VEGF) belong to a group of hypoxia related proteins. IGF-I induces expression of VEGF and decomposes wild type p53 in cancer cell lines. The goal of our study was to evaluate serum IGF-I, VEGF and p53 with respect to overall and disease free survival of patients with colorectal cancer (CRC) patients compared with healthy volunteers. Methods: Preoperative blood samples from 125 patients with CRC and 16 healthy volunteers were examined using ELISA for serum IGF-I, p53...
Source: Clinical Chemistry and Laboratory Medicine - November 16, 2009 Category: Laboratory Medicine Source Type: journals

Biochemical role of intravaginal sildenafil citrate as a novel antiabortive agent in unexplained recurrent spontaneous miscarriage: first clinical study of four case reports from EgyptEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We conclude that intravaginal sildenafil citrate tablets used as suppositories might be a novel, interesting, safe antiabortive option in the treatment of threatened miscarriage in patients with a history of URSM. We are the first to report this novel clinical application in four case reports in Egypt. Clin Chem Lab Med 2009;47:1433–8. (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - November 16, 2009 Category: Laboratory Medicine Source Type: journals

Potential of the Sebia Capillarys® neonat fast automated system for neonatal screening of sickle cell diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Sebia Capillarys® neonat fast automated system is a reliable tool for haemoglobinopathy neonatal screening. Clin Chem Lab Med 2009;47:1423–32. (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - November 16, 2009 Category: Laboratory Medicine Source Type: journals

A new turbidimetric method for assaying serum C-reactive protein based on phosphocholine interactionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The functional CRP assay allowed measurement of CRP in serum and plasma in the range of 7 mg/L–400 mg/L. The assay is particularly suited in conditions where resources are restricted. Since the assay is species independent, the described functional CRP assay could be used for veterinary purposes as well. Clin Chem Lab Med 2009;47:1417–22. (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - November 16, 2009 Category: Laboratory Medicine Source Type: journals

Potential utility of the new Sysmex XE 5000 red blood cell extended parameters in the study of disorders of iron metabolismEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical Chemistry and Laboratory Medicine 47 (11): 1411-1416 Abstract Background: New erythrocyte parameters are reported by the Sysmex XE 5000 analyzer. This instrument measures the hemoglobin (Hb) content of individual red cells, calculates the percentage of hypochromic red cells (%Hypo He) and the percentage of hyperchromic red cells (%Hyper He) and quantifies the proportion of marginally sized erythrocytes (%Micro R and %Macro R). The goals of the study were to establish the reference range for erythrocyte extended parameters, their value in different types of anemia and to investigate their reliability in the study o...
Source: Clinical Chemistry and Laboratory Medicine - November 16, 2009 Category: Laboratory Medicine Source Type: journals

Markers of infection in inpatients and outpatients with acute Q-feverEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Acute Q-fever, a relatively mild pneumonia with low CURB-65 scores, specifically induces a response in CRP, while PCT concentrations and leukocytes are within the normal range or increased only marginally. Clin Chem Lab Med 2009;47:1407–9. (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - November 16, 2009 Category: Laboratory Medicine Source Type: journals

The rate of manual peripheral blood smear reviews in outpatientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical Chemistry and Laboratory Medicine 47 (11): 1401-1405 Abstract Background: The International Consensus Group for Hematology Review recommends manual blood smears for new findings from automated complete blood cell (CBC) tests. However, in outpatients, the rate of peripheral manual blood smear reviews is uncertain, as is the effect of historical results on this rate. Methods: In a prospective cohort study of 687,955 members of a health maintenance organization, we extracted 39,759 consecutive automated CBC test results and determined the rate of manual peripheral smear reviews that were indicated using different tri...
Source: Clinical Chemistry and Laboratory Medicine - November 16, 2009 Category: Laboratory Medicine Source Type: journals

Detection of myelin autoantibodies: evaluation of an assay system for diagnosis of multiple sclerosis in differentiation from other central nervous system diseasesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The ELISA kit we evaluated is suitable for the measurement of neuronal autoantibodies. The initial validation demonstrates its potential use in the differential diagnosis of central neuronal system diseases. Clin Chem Lab Med 2009;47:1395–400. (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - November 16, 2009 Category: Laboratory Medicine Source Type: journals

Impaired anti-inflammatory function of apolipoprotein A-II concentrations predicts metabolic syndrome and diabetes at 4 years follow-up in elderly TurksEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Serum apoA-II concentrations confer risk for MetS and diabetes and exhibit evidence of anti-inflammatory properties among Turks. These findings support the effects seen for several other HDL protein constituents. This finding may explain the increased cardiometabolic risk among Turks. Clin Chem Lab Med 2009;47:1389–94. (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - November 16, 2009 Category: Laboratory Medicine Source Type: journals

Enhanced bone metabolism in vegetarians – the role of vitamin B12 deficiencyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Low vitamin B12 status is related to increased bone turnover in vegetarians which is independent from vitamin D status. Clin Chem Lab Med 2009;47:1381–7. (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - November 16, 2009 Category: Laboratory Medicine Source Type: journals

Serum albumin fragmentation in end-stage renal disease patients – a pilot studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results indicate that in addition to increased expression of LMWP, a relevant amount of albumin fragments are detectable in the serum of patients undergoing MHD. Uremia appears to facilitate the fragmentation of albumin and/or the retention of albumin fragments in blood. Clin Chem Lab Med 2009;47:1373–9. (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - November 16, 2009 Category: Laboratory Medicine Source Type: journals

Prevalence of thyroid autoimmunity and subclinical hypothyroidism in persons with chronic kidney disease not requiring chronic dialysisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical Chemistry and Laboratory Medicine 47 (11): 1367-1371 Abstract Background: The prevalence of thyroid autoimmunity and subclinical primary hypothyroidism in persons with chronic kidney disease (CKD) not requiring chronic dialysis is not well defined. Methods: We studied 1000 consecutive adult outpatients who were referred by their general practitioner for blood testing over the last 2 years. We excluded those with abnormal serum free thyroxine (FT4) levels (n=85). No participants required chronic renal replacement therapy. Thyroid autoimmunity was defined as increased concentrations of serum anti-thyroid antibodies....
Source: Clinical Chemistry and Laboratory Medicine - November 16, 2009 Category: Laboratory Medicine Source Type: journals

Comparison of visual vs. automated detection of lipemic, icteric and hemolyzed specimens: can we rely on a human eye?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Visual inspection of lipemic, icteric and hemolyzed samples is highly unreliable and should be replaced by automated systems that report serum indices. Clin Chem Lab Med 2009;47:1361–5. (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - November 16, 2009 Category: Laboratory Medicine Source Type: journals

Molecular diagnostics in acute leukemiasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical Chemistry and Laboratory Medicine 47 (11): 1333-1341 Abstract Acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) both represent highly heterogeneous entities on the basis of diverse cyto- and molecular genetic alterations with considerable influence on prognosis and therapeutic decisions. In recent years, insights into the complex network of molecular markers underlying this diversity have shown marked progress due to the detection of novel mutations, such as nucleophosmin gene (NPM1) in AML, and due to the description of cooperation pathways in leukemogenesis. Also, targeted therapeutic strategie...
Source: Clinical Chemistry and Laboratory Medicine - November 16, 2009 Category: Laboratory Medicine Source Type: journals

Discordant total and free prostate-specific antigen (PSA) assays: does calibration with WHO reference materials diminish the problem?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical Chemistry and Laboratory Medicine 47 (11): 1325-1331 Abstract Prostate-specific antigen (PSA) assay-dependent variations could result in misinterpretation of individual PSA values. Therefore, the situation for clinical interpretation of PSA or percent free PSA (%fPSA) results is complicated. This review summarizes the differences in various total PSA (tPSA) and free PSA (fPSA) assays, and results obtained using the new World Health Organization (WHO) calibrated Access assays from various studies. Method comparisons between the traditionally calibrated Hybritech PSA and fPSA assays and the new “standardized” WH...
Source: Clinical Chemistry and Laboratory Medicine - November 16, 2009 Category: Laboratory Medicine Source Type: journals

The Journal Impact Factor: don't expect its demise any time soonEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical Chemistry and Laboratory Medicine 47 (11): 1319-1324 Abstract Much emphasis continues to be placed on the Journal Impact Factor (IF), a measure of journal article citation rates, and typically used as a surrogate marker of quality of both the article and journal. The IF is both revered and reviled, and is neither a perfect nor comprehensive measure, having several limitations and being subject to easy manipulation. The IF holds ‘power’ for journals because it can influence their future success. Furthermore, the perceived utility of the IF has grown way beyond that of its original and still popular use as a sur...
Source: Clinical Chemistry and Laboratory Medicine - November 16, 2009 Category: Laboratory Medicine Source Type: journals

Journal Impact Factor: it will go away soonEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical Chemistry and Laboratory Medicine 47 (11): 1317-1318 (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - November 16, 2009 Category: Laboratory Medicine Source Type: journals

Development and implementation of an automatic system for verification, validation and delivery of laboratory test resultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical Chemistry and Laboratory Medicine 47 (11): 1355-1360 Abstract Background: The verification/validation of laboratory test results is one of the most critical aspects of the total testing process, which may produce conflicts between competencies and duties at the point of professional crossroads. This process has centered for decades on the human component, with positive effects as well as potential adverse consequences (postanalytical errors). Manual validation of data is a time-consuming activity, is inherently subjective and arbitrary, and requires the constant presence of postgraduate physicians or biologists wi...
Source: Clinical Chemistry and Laboratory Medicine - November 9, 2009 Category: Laboratory Medicine Source Type: journals

Meta-analyses of diagnostic studiesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Reported sensitivities and specificities of different studies assessing similar diagnostic tests are not only negatively correlated, but also negatively correlated in a curvilinear manner. It is appropriate to take this negative curvilinear correlation into account in the data pooling of such meta-analyses. The DORs can be applied for that purpose. Clin Chem Lab Med 2009;47:1351–4. (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - November 9, 2009 Category: Laboratory Medicine Source Type: journals

The journal impact factor: navigating between Scylla and CharybdisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical Chemistry and Laboratory Medicine 47 (11): 1315-1316 (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - November 1, 2009 Category: Laboratory Medicine Source Type: journals

Considerations for the development of a reference method for sequencing of haploid DNA – an opinion paper on behalf of the IFCC Committee on Molecular Diagnostics. International Federation of Clinical Chemistry and Laboratory MedicineEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical Chemistry and Laboratory Medicine 47 (11): 1343-1350 Abstract Following the completion of sequencing of the human genome, there has been a very rapid increase in the development of new molecular diagnostic tests. However, the numerous genetic tests and genetic testing technologies offered do not always satisfy essential quality criteria required to ensure confidence in the results that are produced. This is of particular importance for genetic tests since many patients may be tested for a particular genetic defect only once in their lifetime. Thus, there is a pressing need for comprehensive guidelines for the vali...
Source: Clinical Chemistry and Laboratory Medicine - November 1, 2009 Category: Laboratory Medicine Source Type: journals

41st National Congress of the Italian Society of Clinical Biochemistry and Clinical Molecular Biology, 2nd Joint National Event SIBioC-SIMeLEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical Chemistry and Laboratory Medicine 47 (10): A103-A124 (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - October 6, 2009 Category: Laboratory Medicine Source Type: journals

A novel nonsense mutation in the albumin gene (c.1275 C>A) causing analbuminemia in a Tunisian boyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical Chemistry and Laboratory Medicine 47 (10): 1311-1313 (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - October 6, 2009 Category: Laboratory Medicine Source Type: journals

Should gender-related reference values be used for total bilirubin?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical Chemistry and Laboratory Medicine 47 (10): 1309-1310 (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - October 6, 2009 Category: Laboratory Medicine Source Type: journals

Clinical value of a competitive NT-proBNP enzyme immunoassay compared to the Roche NT-proBNP platformEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical Chemistry and Laboratory Medicine 47 (10): 1305-1308 (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - October 6, 2009 Category: Laboratory Medicine Source Type: journals

Impact of calibration fitting models on the clinical value of chromogranin AEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We showed that the four-parameter logistic calibration model with estimated variance function should better support clinical interpretation of marker concentration changes in patients serially tested. Clin Chem Lab Med 2009;47:1297–303. (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - October 6, 2009 Category: Laboratory Medicine Source Type: journals

The soluble transferrin receptor (TfR)-F-Index is not applicable as a test for iron status in patients with chronic lymphocytic leukemiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical Chemistry and Laboratory Medicine 47 (10): 1291-1295 Abstract Background: The soluble transferrin receptor (sTfR) is established as a test for iron deficiency (ID). In chronic lymphocytic leukemia (CLL), sTfR is not reliable for screening for ID as the latter is strongly dependent on tumor burden. Methods: We investigated whether the influence of the tumor load can be excluded or minimized using the sTfR/log ferritin ratio (TfR-F-Index) and the C-reactive protein (CRP)-adjusted TfR-F-Index in 87 patients with CLL. sTfR was measured nephelometrically (normal: 0.81–1.75 mg/L). A cut-off value of 1.5 for the TfR-F...
Source: Clinical Chemistry and Laboratory Medicine - October 6, 2009 Category: Laboratory Medicine Source Type: journals

Evaluation of a new method for the diagnosis of alterations of Lens culinaris agglutinin binding of thyroglobulin molecules in thyroid carcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results suggest that this method could distinguish between benign and malignant lesions and may be useful for screening serum and wash samples. Clin Chem Lab Med 2009;47:1285–90. (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - October 6, 2009 Category: Laboratory Medicine Source Type: journals

The prognostic utility of haptoglobin genotypes in squamous cell carcinoma of the head and neckEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The present data show that the Hp genotype is closely related to recurrence rate in patients with HNSCC. Patients with Hp 2-2 or 2-0 have greater locoregional recurrence and significantly increased HRs in multivariate analysis. The Hp genotype may be a prognostic factor in patients with HNSCC. Clin Chem Lab Med 2009;47:1277–83. (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - October 6, 2009 Category: Laboratory Medicine Source Type: journals

Detection of Meningeosis neoplastica by real-time quantitation of telomerase activityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We conclude that TA is a promising marker for the detection of Meningeosis neoplastica and warrants further study. Clin Chem Lab Med 2009;47:1271–6. (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - October 6, 2009 Category: Laboratory Medicine Source Type: journals

Pre-transplant serum concentrations of anti-endothelial cell antibody in panel reactive antibody negative renal recipients and its impact on acute rejectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Positive AECA was an independent risk factor for AR and appeared to correlate with relatively severe rejection subtypes. Clin Chem Lab Med 2009;47:1265–9. (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - October 6, 2009 Category: Laboratory Medicine Source Type: journals

HbA1c measurements from dried blood spots: validation and patient satisfactionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Home HbA1c sampling on filter paper is an acceptable sampling alternative for analysis of HbA1c. Clin Chem Lab Med 2009;47:1259–64. (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - October 6, 2009 Category: Laboratory Medicine Source Type: journals

Error tracking in a clinical biochemistry laboratoryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Each clinical laboratory should record errors in a structured manner. A relation database is a useful tool for the recording and extraction of data, as the database can be structured to reflect the workflow at each individual laboratory. Clin Chem Lab Med 2009;47:1253–7. (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - October 6, 2009 Category: Laboratory Medicine Source Type: journals

–308G>A and –1031T>C tumor necrosis factor gene polymorphisms in Tunisian patients with coronary artery diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We conclude that TNF promoter gene polymorphisms at position –308G>A and –1031T>C do not play a major role in the pathogenesis of CAD in the Tunisian population. Clin Chem Lab Med 2009;47:1247–51. (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - October 6, 2009 Category: Laboratory Medicine Source Type: journals

Novel rare alleles of ABCA1 are exclusively associated with extreme high-density lipoprotein-cholesterol levels among the Han ChineseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results show that some rare alleles of ABCA1 are associated with marked phenotypes, supporting the “rare-variant common-disease” hypothesis. Certain alleles also provide tools for identifying individuals at high risk of dyslipidaemia, allowing for early therapeutic intervention. Clin Chem Lab Med 2009;47:1239–45. (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - October 6, 2009 Category: Laboratory Medicine Source Type: journals

Egyptian glycogen storage disease type III – identification of six novel AGL mutations, including a large 1.5 kb deletion and a missense mutation p.L620P with subtype IIIdEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results suggest that there is allelic and phenotypic heterogeneity of GSD III in Egypt. This is the second description of a large deletion in AGL. p.L620P is the second mutation found in GSD IIId. Clin Chem Lab Med 2009;47:1233–8. (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - October 6, 2009 Category: Laboratory Medicine Source Type: journals

Polymorphisms of the β1-adrenergic receptor gene are associated with essential hypertension in ChineseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The polymorphisms of the ADRB1 gene were associated with essential hypertension. The Arg389Gly polymorphism of the ADRB1 gene confers higher risk for hypertension. Clin Chem Lab Med 2009;47:1227–31. (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - October 6, 2009 Category: Laboratory Medicine Source Type: journals

SOCS3 and IRS-1 gene expression differs between genotype 1 and genotype 2 hepatitis C virus-infected HepG2 cellsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Up-regulation of the SOCS3 gene might be one of the mechanisms governing non-response to therapy and expression of insulin resistance mediated via a direct mechanism at this level of genotype 1b HCV. Clin Chem Lab Med 2009;47:1217–25. (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - October 6, 2009 Category: Laboratory Medicine Source Type: journals

Contributions in Biochemistry and Molecular Biology from China and other top-ranking countries: a 10-year survey of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical Chemistry and Laboratory Medicine 47 (10): 1211-1216 Abstract Over the past decade, research in Biochemistry and Molecular Biology has developed rapidly worldwide. The present study was designed to study the characteristics of publications in Biochemistry and Molecular Biology journals between 1999 and 2008 from the six top-ranking countries – the United States (USA), Japan, Germany, United Kingdom (UK), China and France. We also examined the research output from three different regions – Mainland China (ML), Hong Kong (HK) and Taiwan (TW). The USA contributed 34.1% of the world's total output and ranked first...
Source: Clinical Chemistry and Laboratory Medicine - October 6, 2009 Category: Laboratory Medicine Source Type: journals

Increasing laboratory medicine activities in China: research and publicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical Chemistry and Laboratory Medicine 47 (10): 1209-1209 (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - October 6, 2009 Category: Laboratory Medicine Source Type: journals

Quantity quotient reporting. CounterpointEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical Chemistry and Laboratory Medicine 47 (10): 1207-1208 (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - October 6, 2009 Category: Laboratory Medicine Source Type: journals

Quantity quotient reporting. A proposal for a standardized presentation of laboratory resultsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical Chemistry and Laboratory Medicine 47 (10): 1203-1206 Abstract Laboratory results are reported in different units (despite international recommendations for SI units) together with different reference limits, of which several exist for many quantities. It is proposed to adopt the concept of the intelligence quotient and to report quantitative results as a quantity quotient (QQ) in laboratory medicine. This quotient is essentially the difference (measured result minus mean or mode value of the reference interval) divided by the observed biological variation CVo. Thus, all quantities are reported in the same unit sys...
Source: Clinical Chemistry and Laboratory Medicine - October 6, 2009 Category: Laboratory Medicine Source Type: journals

The future of hospital laboratories. Position statement from the Royal Belgian Society of Clinical Chemistry (RBSCC)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical Chemistry and Laboratory Medicine 47 (10): 1195-1201 Abstract To face the economic pressures arising from the current socio-economic conjuncture, hospital laboratories are endangered by an increasing trend towards the outsourcing of clinical laboratory tests to external (mega-) laboratories. This should allow hospitals to meet their economic requirements, but with an increased risk of loss of medical quality and, mid- to long-term, loss of cost effectiveness of healthcare at the national level. To anticipate current developments (economical and technological) that inevitably will affect the future of laboratory me...
Source: Clinical Chemistry and Laboratory Medicine - October 6, 2009 Category: Laboratory Medicine Source Type: journals

Genetic and biochemical heterogeneity of cardiac troponins: clinical and laboratory implicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical Chemistry and Laboratory Medicine 47 (10): 1183-1194 Abstract The contractile sarcomeric pool of skeletal muscle and heart consists of a highly-ordered arrangement of actin thin filaments, tropomyosin and proteins of the troponin complex: troponin I (TnI), troponin T (TnT) and troponin C (TnC). The cardiac myocyte expresses specific isoforms of both TnI and TnT (cTnI and cTnT, respectively), which can be distinguished from skeletal muscle isoforms by rapid and reliable immunoassays. Due to their superior cardiac specificity, cTnI and cTnT have become the recommended biomarkers for the diagnosis of myocardial injur...
Source: Clinical Chemistry and Laboratory Medicine - October 6, 2009 Category: Laboratory Medicine Source Type: journals

A critical appraisal of experimental factors influencing the definition of the 99th percentile limit for cardiac troponinsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In conclusion, a number of issues can markedly influence the definition of the 99th URL for cTn, which most clinicians are unaware of and may markedly condition the clinical performance of the test in routine practice. Clin Chem Lab Med 2009;47:1179–82. (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - October 6, 2009 Category: Laboratory Medicine Source Type: journals

Measurement of circulating concentrations of cardiac troponin I and T in healthy subjects: a tool for monitoring myocardial tissue renewal?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical Chemistry and Laboratory Medicine 47 (10): 1167-1177 Abstract The increased analytical sensitivity of the new generation of methods for cardiac troponin I (cTnI) and T (cTnT) has demonstrated that measurable troponin is present in the blood of healthy adult subjects. These data are not in accordance with the prevailing opinion that any reliably detected increase in cardiac troponins should be considered abnormal and potentially caused by cardiac necrosis. The goal of the present review is to discuss the hypothesis that cardiac troponins can be released from cardiomyocytes, even in healthy adult subjects as a resul...
Source: Clinical Chemistry and Laboratory Medicine - October 6, 2009 Category: Laboratory Medicine Source Type: journals

Cardiac troponins: what we knew, what we know – where are we now?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical Chemistry and Laboratory Medicine 47 (10): 1165-1166 (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - September 30, 2009 Category: Laboratory Medicine Source Type: journals

8th Panhellenic Clinical Chemistry Congress, Patras, Greece, October 2–4, 2009Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clinical Chemistry and Laboratory Medicine 47 (9): A79-A102 (Source: Clinical Chemistry and Laboratory Medicine)
Source: Clinical Chemistry and Laboratory Medicine - September 4, 2009 Category: Laboratory Medicine Source Type: journals