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Can hormones contained in mothers' milk account for the beneficial effect of breast-feeding on obesity in children?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nutrition and growth during infancy are an emerging issue because of their potential link to metabolic health disorders in later life. Moreover, prolonged breast-feeding appears to be associated with a lower risk of obesity than formula feeding. Human milk is a source of various hormones and growth factors, namely adipokines (leptin and adiponectin), ghrelin, resistin and obestatin, which are involved in food intake regulation and energy balance. These compounds are either not found in commercial milk formulas or their presence is still controversial. Diet-related differences during infancy in serum levels of factors invol...
Source: Clinical Endocrinology - November 11, 2009 Category: Endocrinology Authors: Francesco Savino, Maria F. Fissore, Stefania A. Liguori, Roberto Oggero Tags: Review Article Source Type: journals

RefereesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical Endocrinology)
Source: Clinical Endocrinology - November 9, 2009 Category: Endocrinology Tags: Referees Source Type: journals

Colostrum iodine and perchlorate concentrations in Boston-area women: a cross-sectional studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical Endocrinology)
Source: Clinical Endocrinology - November 9, 2009 Category: Endocrinology Authors: Angela M. Leung, Elizabeth N. Pearce, Tara Hamilton, Xuemei He, Sam Pino, Anne Merewood, Lewis E. Braverman Tags: Corrigendum Source Type: journals

Activational effects of sex hormones on cognition in menEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions Although there is convincing evidence that steroid sex hormones play an organizational role in brain development in men, the evidence for activational effects of sex hormones affecting cognition in healthy men throughout adult life remains inconsistent. To address this issue, a new multifactorial approach is proposed which takes into account the status of other elements of the sex hormones axis including receptors, enzymes and other hormones. (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - October 7, 2009 Category: Endocrinology Authors: A. Ulubaev, D. M. Lee, N. Purandare, N. Pendleton, F. C. W. Wu Tags: Review Article Source Type: journals

Testicular dysgenesis syndrome: foetal origin of adult reproductive problemsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The evidence for the existence of testicular dysgenesis syndrome (TDS) is presented in this review. Several epidemiological studies have shown that conditions like cryptorchidism, impaired spermatogenesis, hypospadias and testicular cancer can be associated as risk factors for each other. Thus, the risk of testis cancer is significantly increased in men with cryptorchidism and/or infertility. Several recent studies point towards early dysgenesis of the foetal testis as the biological link between these disorders. Dysgenesis has been demonstrated in biopsies of the contralateral testis of men with testis cancer and in infer...
Source: Clinical Endocrinology - September 9, 2009 Category: Endocrinology Authors: Christine Wohlfahrt-Veje, Katharina M. Main, Niels Erik Skakkebæk Tags: Review Article Source Type: journals

AddendumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical Endocrinology)
Source: Clinical Endocrinology - September 6, 2009 Category: Endocrinology Tags: Addendum Source Type: journals

New and emerging treatments for osteoporosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A variety of new treatments for osteoporosis have become available within the last several years, and a number of emerging treatments remain in late clinical stage development. New and emerging treatments include more potent members, or more convenient formulations, of existing classes of therapy, but a number of the emerging treatments are first-generation compounds addressing specific therapeutic targets based on recent advances in understanding of basic bone biology. These new and emerging treatments include agents with anticatabolic effects, compounds with anabolic effects, and one agent possibly containing both antica...
Source: Clinical Endocrinology - August 16, 2009 Category: Endocrinology Authors: Bart L. Clarke Tags: Review Article Source Type: journals

Clinical complications following thyroid fine-needle biopsy: a systematic reviewEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Thyroid fine-needle biopsy (FNB) is a simple, reliable, inexpensive and generally safe diagnostic procedure in the management of thyroid nodules. Post-FNB local pain and minor haematomas are the most common complications, while serious complications seem to be rare. Given that use of FNB minimizes unnecessary surgery and subsequent operative morbidity and mortality as well as the fact that the majority of FNB complications resolve spontaneously, the overall safety of FNB is not questioned. However, awareness of the potential complications and careful estimation of the risk-benefit ratio in an individual basis may further d...
Source: Clinical Endocrinology - July 7, 2009 Category: Endocrinology Authors: Stergios A. Polyzos, Athanasios D. Anastasilakis Tags: Review Article Source Type: journals

Role of aldosterone and angiotensin II in insulin resistance: an updateEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The role of the Renin[ndash]Angiotensin[ndash]Aldosterone system (RAAS) on the development of insulin resistance and cardiovascular disease is an area of growing interest. Most of the deleterious actions of the RAAS on insulin sensitivity appear to be mediated through activation of the Angiotensin II (Ang II) Receptor type 1 (AT1R) and increased production of mineralocorticoids. The underlying mechanisms leading to impaired insulin sensitivity remain to be fully elucidated, but involve increased production of reactive oxygen species and oxidative stress. Both experimental and clinical studies also implicate aldosterone in ...
Source: Clinical Endocrinology - June 27, 2009 Category: Endocrinology Authors: Guido Lastra-Lastra, James R. Sowers, Katherine Restrepo-Erazo, Camila Manrique-Acevedo, Guido Lastra-González Tags: Review Article Source Type: journals

Commentary on 'Parathyroidectomy is safe and improves symptoms in elderly patients with PHPT'Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19341438 [PubMed - as supplied by publisher] (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - March 31, 2009 Category: Endocrinology Authors: Harrison B Tags: Clin Endocrinol (Oxf) Source Type: journals

Can hormones contained in mothers' milk account for the beneficial effect of breast-feeding on obesity in children?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Nutrition and growth during infancy are an emerging issue because of their potential link to metabolic health disorders in later life. Moreover, prolonged breastfeeding appears to be associated with a lower risk of obesity than formula-feeding. Human milk is a source of various hormones and growth factors, namely adipokines (leptin and adiponectin), ghrelin, resistin and obestatin, which are involved in food intake regulation and energy balance. These compounds are either not found in commercial milk formulas or their presence is still controversial. Diet-related differences during infancy in serum levels of factors in...
Source: Clinical Endocrinology - March 19, 2009 Category: Endocrinology Authors: Savino F, Fissore MF, Liguori SA, Oggero R Tags: Clin Endocrinol (Oxf) Source Type: journals

Comparison of three doses of leuprolide acetate in the treatment of central precocious puberty: preliminary results.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These results affirm that 3-monthly injections may be a satisfactory alternative for the therapy of children with CPP to avoid monthly injections. In addition, suppression of LH occurs sooner in the 3-month 22.5 mg LA dose compared to the 3- month 11.5 mg, so adequate dosing may be important for optimal outcome. Further investigation is needed in more patients over 30 kg, with longer treatment duration, and ultimately final height consideration. PMID: 19302581 [PubMed - as supplied by publisher] (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - March 19, 2009 Category: Endocrinology Authors: Mericq V, Lammoglia JJ, Unanue N, Villaroel C, Hernández M, Avila A, Iñiguez G, Klein KO Tags: Clin Endocrinol (Oxf) Source Type: journals

The natural history of surgically treated but radiotherapy naïve non-functioning pituitary adenomas.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: These results indicate that patients with post-operative tumour with an extrasellar remnant should be considered routinely for adjuvant RT to reduce the risk of tumour regrowth while those with no residual tumour can be safely observed. Individualised decisions should be made for patients with an intrasellar remnant. PMID: 19302582 [PubMed - as supplied by publisher] (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - March 19, 2009 Category: Endocrinology Authors: O'Sullivan EP, Woods C, Glynn N, Behan LA, Crowley R, O'Kelly P, Smith D, Thompson CJ, Agha A Tags: Clin Endocrinol (Oxf) Source Type: journals

Measurement of salivary cortisol with liquid chromatography-tandem mass spectrometry in patients undergoing dynamic endocrine testing.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We have shown an excellent diagnostic sensitivity and specificity of LC-MS/MS SalC in the assessment of the HPA axis and superiority over SerC when CBG levels are altered. The exponential relationship between SerC and SalC supports the concept of CBG binding capacity saturation. PMID: 19302583 [PubMed - as supplied by publisher] (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - March 19, 2009 Category: Endocrinology Authors: Perogamvros I, Owen LJ, Keevil BG, Brabant G, Trainer PJ Tags: Clin Endocrinol (Oxf) Source Type: journals

Unusual mid-shaft fractures during long term bisphosphonate therapy.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Long-term bisphosphonate therapy may increase the risk of unusual long bone mid-shaft fractures. This is likely due to prolonged suppression of bone turnover, which could lead to accumulation of microdamage and development of hypermineralized bone. At present, the scope of this complication in the larger context of patients receiving bisphosphonate therapy is not known, but appears to be small. PMID: 19302584 [PubMed - as supplied by publisher] (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - March 19, 2009 Category: Endocrinology Authors: Odvina CV, Levy S, Rao S, Zerwekh JE, Sudhaker Rao D Tags: Clin Endocrinol (Oxf) Source Type: journals

GH replacement in patients with non-functioning pituitary adenoma (NFA) treated solely by surgery is not associated with increased risk of tumour recurrence.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion GH replacement in patients with NFA treated by surgery alone is not associated with an increased risk of tumour recurrence. PMID: 19236640 [PubMed - in process] (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - February 26, 2009 Category: Endocrinology Authors: Arnold JR, Arnold DF, Marland A, Karavitaki N, Wass JA Tags: Clin Endocrinol (Oxf) Source Type: journals

Clinical Question: How do you approach the problem of TSH elevation in a patient on high dose thyroid hormone replacement?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary Persistent elevation of TSH levels in patients under treatment for hypothyroidism is a relatively common clinical problem in Endocrinology practice. The most common cause for this phenomenon is poor patient compliance with their thyroid hormone tablets. In the compliant patient however, multiple etiologies are possible and a methodological and step-wise approach to the patient's problem will uniformly identify a cause, or at least a resolution. PMID: 19226259 [PubMed - as supplied by publisher] (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - February 18, 2009 Category: Endocrinology Authors: Morris JC Tags: Clin Endocrinol (Oxf) Source Type: journals

Lower bone mineral density is associated with higher coronary calcification and coronary plaque burdens by multidetector row coronary computed tomography in pre- and post-menopausal women.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Increased CCS and subclinical atherosclerosis of plaque burdens as seen by MDCT was associated with a low BMD in all women, independent of cardiovascular risk factors and age. PMID: 19226260 [PubMed - as supplied by publisher] (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - February 18, 2009 Category: Endocrinology Authors: Choi SH, An JH, Lim S, Koo BK, Park SE, Chang HJ, Choi SI, Park YJ, Park KS, Jang HC, Shin CS Tags: Clin Endocrinol (Oxf) Source Type: journals

The use of thyroid function tests in the diagnosis of hypopituitarism: definition and evaluation of the TSH Index.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The TSH Index provides an accurate estimate of the severity of pituitary dysfunction in hypopituitary patients based on simple TFTs. It predicts the probability of pituitary stimulation test failure, and extends the diagnosis of TSH deficiency into areas of the normal TFT reference ranges. PMID: 19226261 [PubMed - as supplied by publisher] (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - February 18, 2009 Category: Endocrinology Authors: Jostel A, Ryder WD, Shalet SM Tags: Clin Endocrinol (Oxf) Source Type: journals

Markers of insulin sensitivity in placentas and cord serum of intrauterine growth restricted (IUGR) newborns.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This study evaluated the markers of insulin sensitivity in the placentas of subjects born IUGR, showing new potential roles in particular for adiponectin and IL-6, and suggesting a role of the placenta in the programming of these hormones. PMID: 19226262 [PubMed - as supplied by publisher] (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - February 18, 2009 Category: Endocrinology Authors: Street ME, Volta C, Ziveri MA, Viani I, Bernasconi S Tags: Clin Endocrinol (Oxf) Source Type: journals

Novel mutations of the BSCL2 and AGPAT2 genes in ten families with Berardinelli-Seip congenital generalized lipodystrophy syndrome.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We demonstrated four novel mutations of the BSCL2 and AGPAT2 genes responsible for Berardinelli-Seip syndrome and Brunzell syndrome (AGPAT2-related syndrome). PMID: 19226263 [PubMed - as supplied by publisher] (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - February 18, 2009 Category: Endocrinology Authors: Miranda DM, Wajchenberg BL, Calsolari MR, Aguiar MJ, Silva JM, Ribeiro MG, Fonseca C, Amaral D, Boson WL, Resende BA, De Marco L Tags: Clin Endocrinol (Oxf) Source Type: journals

Monitoring of acromegaly: What should be done when growth hormone and IGF-1 levels are discrepant?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
SUMMARY Monitoring of a patient with acromegaly requires periodic evaluation of levels of growth hormone (GH) and insulin-like growth factor I (IGF-1), the biochemical markers of this disease. Although the results of these two tests are usually concordant, they can be discrepant and how to proceed when they are can be a challenging clinical problem. In some cases IGF-1 levels are normal yet GH suppression after oral glucose is abnormal; this pattern may be due to persistent GH dysregulation despite remission. In other cases IGF-1 levels are elevated yet GH suppression appears to be normal; this pattern may be observed ...
Source: Clinical Endocrinology - February 18, 2009 Category: Endocrinology Authors: Freda PU Tags: Clin Endocrinol (Oxf) Source Type: journals

Prevalence of DSMIV mental disorders in acromegaly: a cross-sectional study in 81 acromegalic patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Acromegaly is associated with an increased prevalence and a specific pattern of affective disorders. Greater emphasis on diagnosing and treatment of mental disorders in acromegalic patients might improve the disease management. PMID: 19226265 [PubMed - as supplied by publisher] (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - February 18, 2009 Category: Endocrinology Authors: Sievers C, Dimopoulou C, Pfister H, Lieb R, Steffin B, Roemmler J, Schopohl J, Mueller M, Schneider HJ, Ising M, Wittchen HU, Stalla GK Tags: Clin Endocrinol (Oxf) Source Type: journals

Likelihood of persistent growth hormone deficiency into late adolescence: relationship to the presence of an ectopic or normally sited posterior pituitary gland.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: It is important to document GH status at the end of growth, even if there is a structural abnormality of the hypothalamic-pituitary axis. The presence of an EPP compared to a NPP increases the likelihood of persistent GHD by 26%. As all EPP patients had a peak GH level of <10mug/L, the cut-off for persistent GHD in late adolescence may need to be revised. PMID: 19226266 [PubMed - as supplied by publisher] (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - February 18, 2009 Category: Endocrinology Authors: Murray PG, Hague C, Fafoula O, Gleeson H, Patel L, Banerjee I, Raabe AL, Hall CM, Wright NB, Amin R, Clayton PE Tags: Clin Endocrinol (Oxf) Source Type: journals

How do you initiate oestrogen therapy in a girl that has not undergone puberty?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
SUMMARY The physiology of puberty needs to be taken into consideration in the induction of puberty. Puberty is a relatively slow process and replacement therapy should mimic this. Long term maintenance requires careful monitoring and long term assessment of risk-benefit. This has not been appreciably defined in the adolescent population. Options for fertility need careful consideration and may depend on the adequacy of pubertal induction in terms of uterine development. A number of regimens are available for pubertal induction but the lack of comparisons makes it difficult to advocate for a particular regimen. There re...
Source: Clinical Endocrinology - February 18, 2009 Category: Endocrinology Authors: Hindmarsh PC Tags: Clin Endocrinol (Oxf) Source Type: journals

Relationships between cortisol level, mortality and chronic diseases in older persons.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: High salivary cortisol levels are associated with increased mortality risk in a general older population. High cortisol levels are associated with higher risks of hypertension and diabetes mellitus and lower risk of CNSLD. PMID: 19226268 [PubMed - as supplied by publisher] (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - February 18, 2009 Category: Endocrinology Authors: Schoorlemmer RM, Peeters GM, van Schoor NM, Lips P Tags: Clin Endocrinol (Oxf) Source Type: journals

High prevalence of autonomous cortisol and aldosterone secretion from adrenal adenomas.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: By applying new cut-offs, autonomous cortisol and aldosterone secretion in patients with a single adrenal adenoma is very common, and aldosterone secretion correlates with arterial blood pressure. PMID: 19226269 [PubMed - as supplied by publisher] (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - February 18, 2009 Category: Endocrinology Authors: Piaditis GP, Kaltsas GA, Androulakis II, Gouli A, Makras P, Papadogias D, Dimitriou K, Ragkou D, Markou A, Vamvakidis K, Zografos G, Chrousos G Tags: Clin Endocrinol (Oxf) Source Type: journals

Phenotype and genotype in untreated 21-hydroxylase deficient Indonesian patients.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: We conclude that a correlation exist between the concentration of androgens and the extent of virilization. However, there was no clear correlation between genotype and phenotype, except for the mutation R356W. PMID: 19226270 [PubMed - as supplied by publisher] (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - February 18, 2009 Category: Endocrinology Authors: Goossens K, Juniarto AZ, Timmerman MA, Faradz SM, Wolffenbuttel KP, Drop SL, de Jong FH Tags: Clin Endocrinol (Oxf) Source Type: journals

Insulin-like factor 3 as a marker of testicular function in obese men.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: This study showed for the first time that INSL3 levels decrease with obesity, probably as a result of a primary dysfunction of the Leydig cells. INSL3 is a reliable marker of Leydig cell general impairment, whereas testosterone mainly reflects the steroidogenic activity of these cells. PMID: 19226271 [PubMed - as supplied by publisher] (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - February 18, 2009 Category: Endocrinology Authors: Foresta C, Di Mambro A, Pagano C, Garolla A, Vettor R, Ferlin A Tags: Clin Endocrinol (Oxf) Source Type: journals

Vitamin D and mortality in older men and women.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Low 25(OH)D levels are associated with all-cause mortality and even more pronounced with cardiovascular mortality but it remains unclear whether vitamin D deficiency is a cause or a consequence of a poor health status. Therefore, intervention studies are warranted to evaluate whether vitamin D supplementation reduces mortality and cardiovascular diseases. PMID: 19226272 [PubMed - as supplied by publisher] (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - February 18, 2009 Category: Endocrinology Authors: Pilz S, Dobnig H, Nijpels G, Heine RJ, Stehouwer CD, Snijder MB, van Dam RM, Dekker JM Tags: Clin Endocrinol (Oxf) Source Type: journals

Age and sex as predictors of biochemical activity in acromegaly: analysis of 1485 patients from the German Acromegaly Register.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In summary, initial biochemical activity of acromegaly is influenced by patient's age and to a lesser degree by patient's sex. Male patients are on average 6 years younger than females. PMID: 19226273 [PubMed - as supplied by publisher] (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - February 18, 2009 Category: Endocrinology Authors: Petersenn S, Buchfelder M, Gerbert B, Franz H, Quabbe HJ, Schulte HM, Grussendorf M, Reincke M, Tags: Clin Endocrinol (Oxf) Source Type: journals

Plasma visfatin concentrations increase in both hyper and hypothyroid subjects after normalisation of thyroid function and are not related to insulin resistance, anthropometric or inflammatory parameters.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Visfatin exhibits a marked increase after normalisation of thyroid function in both hyper and hypothyroid patients. We suggest that visfatin may play a role in the hormone stabilisation process independently from anthropometric, inflammatory or insulin resistance variables. PMID: 19222486 [PubMed - as supplied by publisher] (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - February 16, 2009 Category: Endocrinology Authors: Caixàs A, Tirado R, Vendrell J, Gallart L, Megia A, Simon I, Llauradó G, Gomzález-Clemente JM, Giménez-Palop O Tags: Clin Endocrinol (Oxf) Source Type: journals

Testicular Dysgenesis Syndrome; Fetal origin of adult reproductive problems.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary The evidence for the existence of a testicular dysgenesis syndrome (TDS) is presented in this review. Several epidemiological studies have shown that conditions like cryptorchidism, impaired spermatogenesis, hypospadias and testicular cancer can be associated as risk factors for each other. Thus, the risk of testis cancer is significantly increased in men with cryptorchidism and /or infertility. Several recent studies point towards early dysgenesis of the fetal testis as the biological link between these disorders. Dysgenesis has been demonstrated in biopsies of the contralateral testis of men with testis cance...
Source: Clinical Endocrinology - February 16, 2009 Category: Endocrinology Authors: Wohlfahrt-Veje C, Main KM, Skakkebæk NE Tags: Clin Endocrinol (Oxf) Source Type: journals

Regulatory T cells in Graves' disease.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: This study provides evidence that there is not a deficit in T regulatory cells during active Graves' disease, or during the months post therapy. PMID: 19222488 [PubMed - as supplied by publisher] (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - February 16, 2009 Category: Endocrinology Authors: Pan D, Shin YH, Gopalakrishnan G, Hennessey J, De Groot LJ Tags: Clin Endocrinol (Oxf) Source Type: journals

Association between low bone mass and aortic valve sclerosis in Koreans.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Low bone mass might be independently associated with increased risk of aortic valve sclerosis in women, but not in men. Women with low bone mass should be further evaluated for the presence of aortic valve sclerosis and related cardiovascular diseases. PMID: 19222489 [PubMed - as supplied by publisher] (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - February 16, 2009 Category: Endocrinology Authors: Choi HS, Rhee Y, Hur NW, Chung N, Lee EJ, Lim SK Tags: Clin Endocrinol (Oxf) Source Type: journals

Clinical Question: How should a non-functioning pituitary macroadenoma be monitored after debulking surgery?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary Transsphenoidal surgery is the treatment of choice for non-functioning pituitary macroadenomas but is seldom curative. Tumour progression rates are high in patients with post-operative remnants. Therefore, long term monitoring is necessary to detect tumour growth, which may be asymptomatic or manifest with visual field defects and/or pituitary dysfunction. In view of the generally slow-growing nature of these tumours, yearly MRI, neuro-ophalmologic and pituitary function evaluation are appropriate during the first 3-5 years after surgery. If there is no evidence for tumour progression during this period, testin...
Source: Clinical Endocrinology - February 16, 2009 Category: Endocrinology Authors: Greenman Y, Stern N Tags: Clin Endocrinol (Oxf) Source Type: journals

New and emerging treatments for osteoporosis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19222491 [PubMed - as supplied by publisher] (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - February 16, 2009 Category: Endocrinology Authors: Clarke BL Tags: Clin Endocrinol (Oxf) Source Type: journals

Parathyroidectomy is safe and improves symptoms in elderly patients with PHPT.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Parathyroidectomy is safe in the elderly and is associated with a significant improvement in symptoms. Since survival after operation is similar to younger patients, surgery should be considered in all elderly patients with PHPT. PMID: 19222492 [PubMed - as supplied by publisher] (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - February 16, 2009 Category: Endocrinology Authors: Stechman MJ, Weisters M, Gleeson FV, Sadler GP, Mihai R Tags: Clin Endocrinol (Oxf) Source Type: journals

A potential role for endogenous progesterone in modulation of growth hormone, prolactin and thyrotropin secretion during normal menstrual cycle.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The present data indicate that in normally cycling young women, daytime GH and PRL secretions are increased in luteal phase. These data also suggest that endogenous progesterone could play a modulation role on pituitary hormones secretion, stimulating GH and PRL release and enhancing the inhibitory action of sleep on TSH secretion. PMID: 19222493 [PubMed - as supplied by publisher] (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - February 16, 2009 Category: Endocrinology Authors: Caufriez A, Leproult R, L'hermite-Balériaux M, Moreno-Reyes R, Copinschi G Tags: Clin Endocrinol (Oxf) Source Type: journals

Glucocorticoid receptor gene variant is associated with increased body fatness in youngsters.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Because the associations between the G-allele of the BclI polymorphism in the glucocorticoid receptor gene and body fat mass in boys were only found in a healthy young population, but not in a comparable, but generally leaner cohort from an older generation, it is suggested that carriers of this polymorphism are likely to be more vulnerable to fat accumulation in today's obesity promoting environment, than non-carriers. PMID: 19222494 [PubMed - as supplied by publisher] (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - February 16, 2009 Category: Endocrinology Authors: Voorhoeve PG, van den Akker EL, van Rossum EF, Koper JW, van Mechelen W, Lamberts SW, Delemarre-van de Waal HA Tags: Clin Endocrinol (Oxf) Source Type: journals

Coexistence of chronic lymphocytic thyroiditis is associated with lower recurrence rates in patients with papillary thyroid carcinoma.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In this study, CLT was commonly associated with PTC and was associated with smaller size of the primary tumour at presentation. CLT was also associated with a reduced risk of recurrence during follow up, although this was not significant after adjustment for other prognostic factors. PMID: 19222495 [PubMed - as supplied by publisher] (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - February 16, 2009 Category: Endocrinology Authors: Kim EY, Kim WG, Kim WB, Kim TY, Kim JM, Ryu JS, Hong SJ, Gong G, Shong YK Tags: Clin Endocrinol (Oxf) Source Type: journals

Puberty induction in Turner syndrome: results of oestrogen treatment on development of secondary sexual characteristics, uterine dimensions and serum hormone levels.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions During GH treatment in TS girls, normal breast development up to B5 can be mimicked, with just a 2-year delay. In a clinical setting, serum hormone levels provide no additional information for evaluating pubertal progression. After age-appropriate pubertal induction, uterine dimensions in women aged nearly 20 years were subnormal. It remains unclear whether this was related to E2 dosage, timing or duration, or factors related to TS. PMID: 19200215 [PubMed - in process] (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - February 1, 2009 Category: Endocrinology Authors: Bannink EM, van Sassen C, van Buuren S, de Jong FH, Lequin M, Mulder PG, de Muinck Keizer-Schrama SM Tags: Clin Endocrinol (Oxf) Source Type: journals

Clinical Question: What should be done in an operating room when an insulinoma cannot be found?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Summary Insulinoma is the most common (functioning) tumour of the pancreas and is highly curable with accurate localization and precise extirpation of the often benign, solitary lesion. Although older reports describe high success rates without preoperative localization, more recent recognition of the overlap among causes of endogenous hyperinsulinism, coupled with the deleterious long-term effects of blind distal pancreatectomy and reoperation, mandate the need for precise preoperative localization or regionalization of the tumour(s). If these criteria have not been met and the surgeon finds him/herself in the operati...
Source: Clinical Endocrinology - January 19, 2009 Category: Endocrinology Authors: Rostambeigi N, Thompson GB Tags: Clin Endocrinol (Oxf) Source Type: journals

Statin therapy as the fundamental therapy for cardiovascular prevention: be careful.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19170713 [PubMed - as supplied by publisher] (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - January 19, 2009 Category: Endocrinology Authors: Mascitelli L, Goldstein MR, Pezzetta F Tags: Clin Endocrinol (Oxf) Source Type: journals

Hyperinsulinaemic hypoglycaemia associated with a heterozygous missense mutation of R1174W in the insulin receptor gene.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: R1174 of the IR gene may be a candidate locus for hyperinsulinaemic hypoglycaemia. Clinical heterogeneity is not uncommon within families as well as among mutation carriers with different amino acid replacements. More pedigrees and long-term follow-up data are needed to document the evolution of beta cell function and clarify the role of R1174 on insulin resistance and hyperinsulinaemic hypoglycaemia. PMID: 19170714 [PubMed - as supplied by publisher] (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - January 19, 2009 Category: Endocrinology Authors: Huang Z, Li Y, Tang T, Xu W, Liao Z, Yao B, Hu G, Weng J Tags: Clin Endocrinol (Oxf) Source Type: journals

Testosterone stimulates extra-hepatic but not hepatic fat oxidation: comparison of oral and transdermal testosterone administration in hypopituitary men.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions. Short-term testosterone administration does not stimulate hepatic fat oxidation but enhances whole body fat oxidation by acting on extra-hepatic tissues. PMID: 19170715 [PubMed - as supplied by publisher] (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - January 19, 2009 Category: Endocrinology Authors: Birzniece V, Meinhardt UJ, Handelsman DJ, Ho KK Tags: Clin Endocrinol (Oxf) Source Type: journals

Plasma monocyte chemoattractant protein-1 and macrophage inflammatory protein-1alpha are increased in patients with polycystic ovary syndrome and associated with adiposity, but unaffected by pioglitazone treatment.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Chemokine levels were significantly increased and showed close associations with measures of adiposity in PCOS patients, but were unchanged during insulin sensitizing treatment with pioglitazone. Our data suggests a fat mass independent association between testosterone and MIF levels in PCOS and the effect of antiandrogen treatment on chemokine levels needs to be examined. PMID: 19170716 [PubMed - as supplied by publisher] (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - January 19, 2009 Category: Endocrinology Authors: Glintborg D, Andersen M, Richelsen B, Bruun JM Tags: Clin Endocrinol (Oxf) Source Type: journals

Clinical complications following thyroid fine needle biopsy: a systematic review.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
SUMMARY Thyroid fine-needle biopsy (FNB) is a simple, reliable, inexpensive and generally safe diagnostic procedure in the management of thyroid nodules. Post-FNB local pain and minor haematomas are the most common complications, while serious complications seem to be rare. Given that use of FNB minimizes unnecessary surgery and subsequent operative morbidity and mortality as well as the fact that the majority of FNB complications resolve spontaneously, the overall safety of FNB is not questioned. However, awareness of the potential complications and careful estimation of the risk-benefit ratio in an individual basis m...
Source: Clinical Endocrinology - January 19, 2009 Category: Endocrinology Authors: Polyzos SA, Anastasilakis AD Tags: Clin Endocrinol (Oxf) Source Type: journals

Clinical Endocrinology in 2009.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19128363 [PubMed - as supplied by publisher] (Source: Clinical Endocrinology)
Source: Clinical Endocrinology - January 1, 2009 Category: Endocrinology Authors: Bevan J, Connell J, Young W Tags: Clin Endocrinol (Oxf) Source Type: journals

What are the keys to successful adrenal venous sampling (AVS) in patients with primary aldosteronism?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Adrenal venous sampling (AVS) is the criterion standard to distinguish between unilateral and bilateral adrenal disease in patients with primary aldosteronism. The keys to successful AVS include appropriate patient selection, careful patient preparation, focused technical expertise, defined protocol, and accurate data interpretation. The use of AVS should be based on patient preferences, patient age, clinical comorbidities, and the clinical probability of finding an aldosterone-producing adenoma. AVS is optimally performed in the fasting state in the morning. AVS is an intricate procedure because the right adrenal vein...
Source: Clinical Endocrinology - January 1, 2009 Category: Endocrinology Authors: Young WF, Stanson AW Tags: Clin Endocrinol (Oxf) Source Type: journals