DNMT1/miR-152-3p/SOS1 signaling axis promotes self-renewal and tumor growth of cancer stem-like cells derived from non-small cell lung cancer
This study aimed to elucidate the underlying mechanism involving the DNMT1/miR-... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - April 15, 2024 Category: Research Authors: Qing Yuan, Rubo Wang, Xiang Li, Fei Sun, Jiazhi Lin, Zhimin Fu and Jiansong Zhang Tags: Research Source Type: research
Polycomb repressive complex 2 and its core component EZH2: potential targeted therapeutic strategies for head and neck squamous cell carcinoma
The polycomb group (PcG) comprises a set of proteins that exert epigenetic regulatory effects and play crucial roles in diverse biological processes, ranging from pluripotency and development to carcinogenesis... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - April 10, 2024 Category: Research Authors: Yuxi Cheng, Zhengzheng Song, Xiaodan Fang and Zhangui Tang Tags: Review Source Type: research
Meta-analysis of epigenetic aging in schizophrenia reveals multifaceted relationships with age, sex, illness duration, and polygenic risk
The study of biological age acceleration may help identify at-risk individuals and reduce the rising global burden of age-related diseases. Using DNA methylation (DNAm) clocks, we investigated biological aging... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - April 8, 2024 Category: Research Authors: Anil P. S. Ori, Loes M. Olde Loohuis, Jerry Guintivano, Eilis Hannon, Emma Dempster, David St. Clair, Nick J. Bass, Andrew McQuillin, Jonathan Mill, Patrick F. Sullivan, Rene S. Kahn, Steve Horvath and Roel A. Ophoff Tags: Research Source Type: research
Epigenetics in diabetic cardiomyopathy
Diabetic cardiomyopathy (DCM) is a critical complication that poses a significant threat to the health of patients with diabetes. The intricate pathological mechanisms of DCM cause diastolic dysfunction, follo... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - April 5, 2024 Category: Research Authors: Xiaozhu Ma, Shuai Mei, Qidamugai Wuyun, Li Zhou, Dating Sun and Jiangtao Yan Tags: Review Source Type: research
Targeting histone demethylases JMJD3 and UTX: selenium as a potential therapeutic agent for cervical cancer
The intriguing connection between selenium and cancer resembles a captivating puzzle that keeps researchers engaged and curious. While selenium has shown promise in reducing cancer risks through supplementatio... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - April 4, 2024 Category: Research Authors: Dezhi Chen, Bo Cai, Yingying Zhu, Yimin Ma, Xiaoting Yu, Jieqi Xiong, Jiaying Shen, Weiwei Tie, Yisheng Zhang and Fei Guo Tags: Research Source Type: research
Nucleosome reorganisation in breast cancer tissues
Nucleosome repositioning in cancer is believed to cause many changes in genome organisation and gene expression. Understanding these changes is important to elucidate fundamental aspects of cancer. It is also ... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - April 1, 2024 Category: Research Authors: Divya R. Jacob, Wilfried M. Guiblet, Hulkar Mamayusupova, Mariya Shtumpf, Isabella Ciuta, Luminita Ruje, Svetlana Gretton, Milena Bikova, Clark Correa, Emily Dellow, Shivam P. Agrawal, Navid Shafiei, Anastasija Drobysevskaja, Chris M. Armstrong, Jonathan Tags: Research Source Type: research
Refining risk prediction in pediatric acute lymphoblastic leukemia through DNA methylation profiling
Acute lymphoblastic leukemia (ALL) is the most prevalent cancer in children, and despite considerable progress in treatment outcomes, relapses still pose significant risks of mortality and long-term complicati... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - March 28, 2024 Category: Research Authors: Adri án Mosquera Orgueira, Olga Krali, Carlos Pérez Míguez, Andrés Peleteiro Raíndo, José Ángel Díaz Arias, Marta Sonia González Pérez, Manuel Mateo Pérez Encinas, Manuel Fernández Sanmartín, Daniel Sinnet, Mats Heyman, Gudmar Lönnerholm, Ul Tags: Research Source Type: research
Low expression of miR-182 caused by DNA hypermethylation accelerates acute lymphocyte leukemia development by targeting PBX3 and BCL2: miR-182 promoter methylation is a predictive marker for hypomethylation agents + BCL2 inhibitor venetoclax
miR-182 promoter hypermethylation frequently occurs in various tumors, including acute myeloid leukemia, and leads to low expression of miR-182. However, whether adult acute lymphocyte leukemia (ALL) cells hav... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - March 26, 2024 Category: Research Authors: Danyang Li, Yigang Yuan, Chen Meng, Zihan Lin, Min Zhao, Liuzhi Shi, Min Li, Daijiao Ye, Yue Cai, Xiaofei He, Haige Ye, Shujuan Zhou, Haixia Zhou and Shenmeng Gao Tags: Research Source Type: research
Head and neck cancer of unknown primary: unveiling primary tumor sites through machine learning on DNA methylation profiles
The unknown tissue of origin in head and neck cancer of unknown primary (hnCUP) leads to invasive diagnostic procedures and unspecific and potentially inefficient treatment options for patients. The most commo... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - March 25, 2024 Category: Research Authors: Leonhard Stark, Atsuko Kasajima, Fabian St ögbauer, Benedikt Schmidl, Jakob Rinecker, Katharina Holzmann, Sarah Färber, Nicole Pfarr, Katja Steiger, Barbara Wollenberg, Jürgen Ruland, Christof Winter and Markus Wirth Tags: Research Source Type: research
A validated restriction enzyme ddPCR cg05575921 (AHRR) assay to accurately assess smoking exposure
In this study, a novel restriction enzyme (RE) digestion-based droplet digital polymerase chain reaction (ddPCR) assay was designed for cg005575921 within the AHRR gene body and compared with matching results obt... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - March 25, 2024 Category: Research Authors: Sandra Fitzgerald, Basharat Bhat, Cristin Print and Gregory T. Jones Tags: Brief Report Source Type: research
Epigenetic scores of blood-based proteins as biomarkers of general cognitive function and brain health
Epigenetic Scores (EpiScores) for blood protein levels have been associated with disease outcomes and measures of brain health, highlighting their potential usefulness as clinical biomarkers. They are typicall... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - March 25, 2024 Category: Research Authors: Hannah M. Smith, Joanna E. Moodie, Karla Monterrubio-G ómez, Danni A. Gadd, Robert F. Hillary, Aleksandra D. Chybowska, Daniel L. McCartney, Archie Campbell, Paul Redmond, Danielle Page, Adele Taylor, Janie Corley, Sarah E. Harris, Maria Valdés Hernánd Tags: Research Source Type: research
Mother adversity and co-residence time impact mother –child similarity in genome-wide and gene-specific methylation profiles
The effects of adverse life events on physical and psychological health, with DNA methylation (DNAm) as a critical underlying mechanism, have been extensively studied. However, the epigenetic resemblance betwe... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - March 20, 2024 Category: Research Authors: Luc ía Labaut, Agustín Lage-Castellanos, María José Rodrigo, Silvia Herrero-Roldán, Colter Mitchell, Jonah Fisher and Inmaculada León Tags: Research Source Type: research
Correction: Increased CpG methylation at the CDH1 locus in inflamed ileal mucosa of patients with Crohn disease
(Source: Clinical Epigenetics)
Source: Clinical Epigenetics - March 18, 2024 Category: Research Authors: Charles de Ponthaud, Solafah Abdalla, Marie-Pierre Belot, Xiaojian Shao, Christophe Penna, Antoine Brouquet and Pierre Bougn ères Tags: Correction Source Type: research
Identification of miR-20b-5p as an inhibitory regulator in cardiac differentiation via TET2 and DNA hydroxymethylation
Congenital heart disease (CHD) is a prevalent congenital cardiac malformation, which lacks effective early biological diagnosis and intervention. MicroRNAs, as epigenetic regulators of cardiac development, pro... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - March 15, 2024 Category: Research Authors: Ke-Xin Li, Jia-Ru Li, Sheng-Jia Zuo, Xudong Li, Xian-Tong Chen, Pei-Yi Xiao, Hui-Tao Li, Ling Sun, Tao Qian, Hao-Min Zhang, Dongxing Zhu, Xi-Yong Yu, Guojun Chen and Xue-Yan Jiang Tags: Research Source Type: research
Epigenetic age acceleration and risk of aortic valve stenosis: a bidirectional Mendelian randomization study
Aortic valve stenosis (AVS) is the most prevalent cardiac valve lesion in developed countries, and pathogenesis is closely related to aging. DNA methylation-based epigenetic clock is now recognized as highly a... (Source: Clinical Epigenetics)
Source: Clinical Epigenetics - March 12, 2024 Category: Research Authors: Wanqian Pan, Qi Huang, Le Zhou, Jia Lin, Xiaojiao Du, Xiaodong Qian, Tingbo Jiang and Weixiang Chen Tags: Research Source Type: research
