Vaccines and monoclonal antibodies: new tools for malaria control
Clin Microbiol Rev. 2024 Apr 24:e0007123. doi: 10.1128/cmr.00071-23. Online ahead of print.ABSTRACTSUMMARYMalaria remains one of the biggest health problems in the world. While significant reductions in malaria morbidity and mortality had been achieved from 2000 to 2015, the favorable trend has stalled, rather significant increases in malaria cases are seen in multiple areas. In 2022, there were 249 million estimated cases, and 608,000 malaria-related deaths, mostly in infants and children aged under 5 years, globally. Therefore, in addition to the expansion of existing anti-malarial control measures, it is critical to dev...
Source: Clinical Microbiology Reviews - April 24, 2024 Category: Microbiology Authors: Kazutoyo Miura Yevel Flores-Garcia Carole A Long Fidel Zavala Source Type: research
Recent development and fighting strategies for lincosamide antibiotic resistance
Clin Microbiol Rev. 2024 Apr 18:e0016123. doi: 10.1128/cmr.00161-23. Online ahead of print.ABSTRACTSUMMARYLincosamides constitute an important class of antibiotics used against a wide range of pathogens, including methicillin-resistant Staphylococcus aureus. However, due to the misuse of lincosamide and co-selection pressure, the resistance to lincosamide has become a serious concern. It is urgently needed to carefully understand the phenomenon and mechanism of lincosamide resistance to effectively prevent and control lincosamide resistance. To date, six mobile lincosamide resistance classes, including lnu, cfr, erm, vga, ...
Source: Clinical Microbiology Reviews - April 18, 2024 Category: Microbiology Authors: Yingying Yang Shiyu Xie Fangjing He Yindi Xu Zhifang Wang Awais Ihsan Xu Wang Source Type: research
Recent development and fighting strategies for lincosamide antibiotic resistance
Clin Microbiol Rev. 2024 Apr 18:e0016123. doi: 10.1128/cmr.00161-23. Online ahead of print.ABSTRACTSUMMARYLincosamides constitute an important class of antibiotics used against a wide range of pathogens, including methicillin-resistant Staphylococcus aureus. However, due to the misuse of lincosamide and co-selection pressure, the resistance to lincosamide has become a serious concern. It is urgently needed to carefully understand the phenomenon and mechanism of lincosamide resistance to effectively prevent and control lincosamide resistance. To date, six mobile lincosamide resistance classes, including lnu, cfr, erm, vga, ...
Source: Clinical Microbiology Reviews - April 18, 2024 Category: Microbiology Authors: Yingying Yang Shiyu Xie Fangjing He Yindi Xu Zhifang Wang Awais Ihsan Xu Wang Source Type: research
Novel antifungals and treatment approaches to tackle resistance and improve outcomes of invasive fungal disease
Clin Microbiol Rev. 2024 Apr 11:e0007423. doi: 10.1128/cmr.00074-23. Online ahead of print.ABSTRACTSUMMARYFungal infections are on the rise, driven by a growing population at risk and climate change. Currently available antifungals include only five classes, and their utility and efficacy in antifungal treatment are limited by one or more of innate or acquired resistance in some fungi, poor penetration into "sequestered" sites, and agent-specific side effect which require frequent patient reassessment and monitoring. Agents with novel mechanisms, favorable pharmacokinetic (PK) profiles including good oral bioavailability, ...
Source: Clinical Microbiology Reviews - April 11, 2024 Category: Microbiology Authors: Martin Hoenigl Amir Arastehfar Maiken Cavling Arendrup Roger Br üggemann Agostinho Carvalho Tom Chiller Sharon Chen Matthias Egger Simon Feys Jean-Pierre Gangneux Jeremy A W Gold Andreas H Groll Jannes Heylen Jeffrey D Jenks Robert Krause Katrien Lagrou Source Type: research
Novel antifungals and treatment approaches to tackle resistance and improve outcomes of invasive fungal disease
Clin Microbiol Rev. 2024 Apr 11:e0007423. doi: 10.1128/cmr.00074-23. Online ahead of print.ABSTRACTSUMMARYFungal infections are on the rise, driven by a growing population at risk and climate change. Currently available antifungals include only five classes, and their utility and efficacy in antifungal treatment are limited by one or more of innate or acquired resistance in some fungi, poor penetration into "sequestered" sites, and agent-specific side effect which require frequent patient reassessment and monitoring. Agents with novel mechanisms, favorable pharmacokinetic (PK) profiles including good oral bioavailability, ...
Source: Clinical Microbiology Reviews - April 11, 2024 Category: Microbiology Authors: Martin Hoenigl Amir Arastehfar Maiken Cavling Arendrup Roger Br üggemann Agostinho Carvalho Tom Chiller Sharon Chen Matthias Egger Simon Feys Jean-Pierre Gangneux Jeremy A W Gold Andreas H Groll Jannes Heylen Jeffrey D Jenks Robert Krause Katrien Lagrou Source Type: research
Novel antifungals and treatment approaches to tackle resistance and improve outcomes of invasive fungal disease
Clin Microbiol Rev. 2024 Apr 11:e0007423. doi: 10.1128/cmr.00074-23. Online ahead of print.ABSTRACTSUMMARYFungal infections are on the rise, driven by a growing population at risk and climate change. Currently available antifungals include only five classes, and their utility and efficacy in antifungal treatment are limited by one or more of innate or acquired resistance in some fungi, poor penetration into "sequestered" sites, and agent-specific side effect which require frequent patient reassessment and monitoring. Agents with novel mechanisms, favorable pharmacokinetic (PK) profiles including good oral bioavailability, ...
Source: Clinical Microbiology Reviews - April 11, 2024 Category: Microbiology Authors: Martin Hoenigl Amir Arastehfar Maiken Cavling Arendrup Roger Br üggemann Agostinho Carvalho Tom Chiller Sharon Chen Matthias Egger Simon Feys Jean-Pierre Gangneux Jeremy A W Gold Andreas H Groll Jannes Heylen Jeffrey D Jenks Robert Krause Katrien Lagrou Source Type: research
Novel antifungals and treatment approaches to tackle resistance and improve outcomes of invasive fungal disease
Clin Microbiol Rev. 2024 Apr 11:e0007423. doi: 10.1128/cmr.00074-23. Online ahead of print.ABSTRACTSUMMARYFungal infections are on the rise, driven by a growing population at risk and climate change. Currently available antifungals include only five classes, and their utility and efficacy in antifungal treatment are limited by one or more of innate or acquired resistance in some fungi, poor penetration into "sequestered" sites, and agent-specific side effect which require frequent patient reassessment and monitoring. Agents with novel mechanisms, favorable pharmacokinetic (PK) profiles including good oral bioavailability, ...
Source: Clinical Microbiology Reviews - April 11, 2024 Category: Microbiology Authors: Martin Hoenigl Amir Arastehfar Maiken Cavling Arendrup Roger Br üggemann Agostinho Carvalho Tom Chiller Sharon Chen Matthias Egger Simon Feys Jean-Pierre Gangneux Jeremy A W Gold Andreas H Groll Jannes Heylen Jeffrey D Jenks Robert Krause Katrien Lagrou Source Type: research
Novel antifungals and treatment approaches to tackle resistance and improve outcomes of invasive fungal disease
Clin Microbiol Rev. 2024 Apr 11:e0007423. doi: 10.1128/cmr.00074-23. Online ahead of print.ABSTRACTSUMMARYFungal infections are on the rise, driven by a growing population at risk and climate change. Currently available antifungals include only five classes, and their utility and efficacy in antifungal treatment are limited by one or more of innate or acquired resistance in some fungi, poor penetration into "sequestered" sites, and agent-specific side effect which require frequent patient reassessment and monitoring. Agents with novel mechanisms, favorable pharmacokinetic (PK) profiles including good oral bioavailability, ...
Source: Clinical Microbiology Reviews - April 11, 2024 Category: Microbiology Authors: Martin Hoenigl Amir Arastehfar Maiken Cavling Arendrup Roger Br üggemann Agostinho Carvalho Tom Chiller Sharon Chen Matthias Egger Simon Feys Jean-Pierre Gangneux Jeremy A W Gold Andreas H Groll Jannes Heylen Jeffrey D Jenks Robert Krause Katrien Lagrou Source Type: research
Novel antifungals and treatment approaches to tackle resistance and improve outcomes of invasive fungal disease
Clin Microbiol Rev. 2024 Apr 11:e0007423. doi: 10.1128/cmr.00074-23. Online ahead of print.ABSTRACTSUMMARYFungal infections are on the rise, driven by a growing population at risk and climate change. Currently available antifungals include only five classes, and their utility and efficacy in antifungal treatment are limited by one or more of innate or acquired resistance in some fungi, poor penetration into "sequestered" sites, and agent-specific side effect which require frequent patient reassessment and monitoring. Agents with novel mechanisms, favorable pharmacokinetic (PK) profiles including good oral bioavailability, ...
Source: Clinical Microbiology Reviews - April 11, 2024 Category: Microbiology Authors: Martin Hoenigl Amir Arastehfar Maiken Cavling Arendrup Roger Br üggemann Agostinho Carvalho Tom Chiller Sharon Chen Matthias Egger Simon Feys Jean-Pierre Gangneux Jeremy A W Gold Andreas H Groll Jannes Heylen Jeffrey D Jenks Robert Krause Katrien Lagrou Source Type: research
Scedosporiosis and lomentosporiosis: modern perspectives on these difficult-to-treat rare mold infections
Clin Microbiol Rev. 2024 Mar 29:e0000423. doi: 10.1128/cmr.00004-23. Online ahead of print.ABSTRACTSUMMARYAlthough Scedosporium species and Lomentospora prolificans are uncommon causes of invasive fungal diseases (IFDs), these infections are associated with high mortality and are costly to treat with a limited armamentarium of antifungal drugs. In light of recent advances, including in the area of new antifungals, the present review provides a timely and updated overview of these IFDs, with a focus on the taxonomy, clinical epidemiology, pathogenesis and host immune response, disease manifestations, diagnosis, antifungal s...
Source: Clinical Microbiology Reviews - March 29, 2024 Category: Microbiology Authors: Chin Fen Neoh Sharon C-A Chen Fanny Lanternier Shio Yen Tio Catriona L Halliday Sarah E Kidd David C M Kong Wieland Meyer Martin Hoenigl Monica A Slavin Source Type: research
Scedosporiosis and lomentosporiosis: modern perspectives on these difficult-to-treat rare mold infections
Clin Microbiol Rev. 2024 Mar 29:e0000423. doi: 10.1128/cmr.00004-23. Online ahead of print.ABSTRACTSUMMARYAlthough Scedosporium species and Lomentospora prolificans are uncommon causes of invasive fungal diseases (IFDs), these infections are associated with high mortality and are costly to treat with a limited armamentarium of antifungal drugs. In light of recent advances, including in the area of new antifungals, the present review provides a timely and updated overview of these IFDs, with a focus on the taxonomy, clinical epidemiology, pathogenesis and host immune response, disease manifestations, diagnosis, antifungal s...
Source: Clinical Microbiology Reviews - March 29, 2024 Category: Microbiology Authors: Chin Fen Neoh Sharon C-A Chen Fanny Lanternier Shio Yen Tio Catriona L Halliday Sarah E Kidd David C M Kong Wieland Meyer Martin Hoenigl Monica A Slavin Source Type: research
Scedosporiosis and lomentosporiosis: modern perspectives on these difficult-to-treat rare mold infections
Clin Microbiol Rev. 2024 Mar 29:e0000423. doi: 10.1128/cmr.00004-23. Online ahead of print.ABSTRACTSUMMARYAlthough Scedosporium species and Lomentospora prolificans are uncommon causes of invasive fungal diseases (IFDs), these infections are associated with high mortality and are costly to treat with a limited armamentarium of antifungal drugs. In light of recent advances, including in the area of new antifungals, the present review provides a timely and updated overview of these IFDs, with a focus on the taxonomy, clinical epidemiology, pathogenesis and host immune response, disease manifestations, diagnosis, antifungal s...
Source: Clinical Microbiology Reviews - March 29, 2024 Category: Microbiology Authors: Chin Fen Neoh Sharon C-A Chen Fanny Lanternier Shio Yen Tio Catriona L Halliday Sarah E Kidd David C M Kong Wieland Meyer Martin Hoenigl Monica A Slavin Source Type: research
Scedosporiosis and lomentosporiosis: modern perspectives on these difficult-to-treat rare mold infections
Clin Microbiol Rev. 2024 Mar 29:e0000423. doi: 10.1128/cmr.00004-23. Online ahead of print.ABSTRACTSUMMARYAlthough Scedosporium species and Lomentospora prolificans are uncommon causes of invasive fungal diseases (IFDs), these infections are associated with high mortality and are costly to treat with a limited armamentarium of antifungal drugs. In light of recent advances, including in the area of new antifungals, the present review provides a timely and updated overview of these IFDs, with a focus on the taxonomy, clinical epidemiology, pathogenesis and host immune response, disease manifestations, diagnosis, antifungal s...
Source: Clinical Microbiology Reviews - March 29, 2024 Category: Microbiology Authors: Chin Fen Neoh Sharon C-A Chen Fanny Lanternier Shio Yen Tio Catriona L Halliday Sarah E Kidd David C M Kong Wieland Meyer Martin Hoenigl Monica A Slavin Source Type: research
Scedosporiosis and lomentosporiosis: modern perspectives on these difficult-to-treat rare mold infections
Clin Microbiol Rev. 2024 Mar 29:e0000423. doi: 10.1128/cmr.00004-23. Online ahead of print.ABSTRACTSUMMARYAlthough Scedosporium species and Lomentospora prolificans are uncommon causes of invasive fungal diseases (IFDs), these infections are associated with high mortality and are costly to treat with a limited armamentarium of antifungal drugs. In light of recent advances, including in the area of new antifungals, the present review provides a timely and updated overview of these IFDs, with a focus on the taxonomy, clinical epidemiology, pathogenesis and host immune response, disease manifestations, diagnosis, antifungal s...
Source: Clinical Microbiology Reviews - March 29, 2024 Category: Microbiology Authors: Chin Fen Neoh Sharon C-A Chen Fanny Lanternier Shio Yen Tio Catriona L Halliday Sarah E Kidd David C M Kong Wieland Meyer Martin Hoenigl Monica A Slavin Source Type: research
Scedosporiosis and lomentosporiosis: modern perspectives on these difficult-to-treat rare mold infections
Clin Microbiol Rev. 2024 Mar 29:e0000423. doi: 10.1128/cmr.00004-23. Online ahead of print.ABSTRACTSUMMARYAlthough Scedosporium species and Lomentospora prolificans are uncommon causes of invasive fungal diseases (IFDs), these infections are associated with high mortality and are costly to treat with a limited armamentarium of antifungal drugs. In light of recent advances, including in the area of new antifungals, the present review provides a timely and updated overview of these IFDs, with a focus on the taxonomy, clinical epidemiology, pathogenesis and host immune response, disease manifestations, diagnosis, antifungal s...
Source: Clinical Microbiology Reviews - March 29, 2024 Category: Microbiology Authors: Chin Fen Neoh Sharon C-A Chen Fanny Lanternier Shio Yen Tio Catriona L Halliday Sarah E Kidd David C M Kong Wieland Meyer Martin Hoenigl Monica A Slavin Source Type: research
