Clinical Neurology and NeurosurgeryThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

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Puusepp's sign—Clinical significance of a forgotten pyramidal signEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The pyramidal signs in the lower extremity can be divided into three groups: (1) Babinski's group characterised by dorsoflexion of the great toe, (2) pyramidal signs marked by plantar flexion of the toes (e.g. Rossolimo's sign), and (3) synkinetic movements such as Strümpell's phenomenon. Puusepp's sign described by the Estonian neurologist and neurosurgeon Ludvig Puusepp belongs to none of these three groups. Its eliciting does not differ from that of Babinski's sign. The response, however, is different and consists of a tonic slow abduction of the little toe. We showed its relevance on the basis of clinical ex...
Source: Clinical Neurology and Neurosurgery - November 4, 2009 Category: Neurosurgery Authors: Pawel Tacik, M. Krasnianski, S. Zierz Tags: Letters to the Editor Source Type: journals

Hydatid spinal cord compression revealing multivisceral hydatidosisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a 13-year-old-girl, who was referred for progressive gait difficulty that had begun 20 days before with in addition paresthesiae in the feet. Clinical examination revealed a spastic paraparesis, with bilateral Babinski sign, a global and sensory loss at T9–T10 level, and percussion of the spinal processes of D6 elicited pain. MRI of the spine revealed a cystic lesion involving the T4 and T5 vertebras on the left, with one process extending into the extradural space compressing the spinal cord () and many further other cystic lesions in the liver (stage III). Chest X-ray showed posterior and left mediastinal opa...
Source: Clinical Neurology and Neurosurgery - November 4, 2009 Category: Neurosurgery Authors: L. Essaadouni, F. Jghaimi, S. Ait BenAli, I. Bouchti, N. Kissani Tags: Letters to the Editor Source Type: journals

Endovascular treatment for moyamoya disease in a Caucasian twin with angioplasty and Wingspan stentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The pathogenesis and genetics of moyamoya disease (MMD) remain a mystery. Here we report a case of female Caucasian adult twins with similar presentations of bilateral MMD that were treated with different surgical modalities. One twin was treated with a bypass and remains event free (defined as either transient ischemic event or stroke) at her 4-year follow-up. The second twin underwent angioplasty to treat a left middle cerebral artery stenosis as well as the placement of a Wingspan stent to treat a right supraclinoid ICA stenosis on separate occasions. The left middle cerebral artery angioplasty thrombosed due ...
Source: Clinical Neurology and Neurosurgery - November 4, 2009 Category: Neurosurgery Authors: Doniel Drazin, Mark Calayag, Edward Gifford, John Dalfino, Junichi Yamamoto, Alan S. Boulos Tags: Case reports Source Type: journals

Primary intracranial leiomyomas: Report of two cases and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In this study, we present two cases of primary intracranial leiomyomas in middle-aged men. Magnetic resonance images (MRI) showed lesions with homogeneous low signals on T1-, T2-, diffusion-weighted, and FLAIR sequences. Tumors were totally removed and there was no evidence of recurrence in the follow-up study. Pathological analysis with immunohistochemistry revealed that tumors had characteristics of benign smooth muscles. A review of relevant literature has been conducted. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - November 4, 2009 Category: Neurosurgery Authors: Wei Hua, Feng Xu, Ying Mao, JiaWen Zhang, Yin Wang, RenLing Mao, LiangFu Zhou Tags: Case reports Source Type: journals

Multiple bilateral non-hemorrhagic cerebral infarctions associated with microscopic polyangiitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of MPA with multiple bilateral non-hemorrhagic cerebral infarctions in a 66-year-old woman who was undergoing steroid pulse therapy. The diagnosis of MPA was based on the presence of painful mononeuritis multiplex, pulmonary fibrosis, and increased myeloperoxidase activity and on the biopsy of the sural nerve. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - November 4, 2009 Category: Neurosurgery Authors: Bon D. Ku, Hyun Young Shin Tags: Case reports Source Type: journals

Pseudohypoxic brain swelling after elective clipping of an unruptured anterior communicating artery aneurysmEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: A case of pseudohypoxic brain swelling, a newly defined entity, is described. The patient experienced generalized seizures and did not awake initially after a seemingly uneventful elective craniotomy for clipping of an unruptured anterior communicating artery aneurysm. Neuroimaging findings demonstrated diffuse brain swelling, especially in the bilateral basal ganglia and thalami. The rarity of this postoperative complication is addressed and the pathogenesis discussed. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - November 4, 2009 Category: Neurosurgery Authors: Hiroshi Yokota, Kazuhiro Yokoyama, Kazunori Miyamoto, Toshikazu Nishioka Tags: Case reports Source Type: journals

Multiple forms of rhythmic movements in an adolescent boy with rhythmic movement disorderEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This report raises the fact that a patient with RMD may present with multiple complex rhythmic movements disrupting sleep, which emphasizes that better understanding of the clinical features of complex rhythmic movements during sleep in primary care settings is essential for early clinical diagnosis and optimal management. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - November 4, 2009 Category: Neurosurgery Authors: Changjun Su, Jianting Miao, Yu Liu, Rui Liu, Gesheng Lei, Wei Zhang, Ting Yang, Zhuyi Li Tags: Case reports Source Type: journals

Epidural hematoma revealed by exophthalmia, two cases reportsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report on two cases of frontal epidural hematoma revealed by an exophthalmia after a minor head trauma. On reporting our cases we aim to increase the awareness of this association each time a head or facial trauma is associated with exophthalmia. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - November 4, 2009 Category: Neurosurgery Authors: K. Bahloul, A. Xhumari Tags: Case reports Source Type: journals

Neuro-Behcet's disease presenting with amnesia and frontal dysfunctionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a 48-year-old patient with neuro-Behcet's disease who presented with the combination of severe memory impairment and frontal/executive dysfunction. The clinical feature mimicked that of diencephalic amnesic syndrome. The MRI and SPECT findings supported the notion that the thalamus and related subcortical–frontal connection was responsible for this patient's problem. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - November 4, 2009 Category: Neurosurgery Authors: Masaru Mimura, Motoichiro Kato, Haruo Kashima Tags: Case reports Source Type: journals

Right-sided neglect influences the writing of Kanji: A case studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Neglect is the failure to report, respond, or orient to novel or meaningful stimuli presented to the side opposite a brain lesion. Here we describe the case of a 73-year-old woman who experienced a writing deficit in the right-sided component of Kanji letters (morphograms) of the Japanese language. Magnetic resonance imaging of the brain showed an infarction in the left middle temporal and occipital gyrus. The patient wrote recognizable, well-formed but paragraphic Kanji letters in both spontaneous and dictated writing. Most letters are composed of two elements: “hen” (left) and “tsukuri” (right). Neograp...
Source: Clinical Neurology and Neurosurgery - November 4, 2009 Category: Neurosurgery Authors: Meiko Hashimoto, Sakae Morii, Yoshikazu Uesaka, Katsuhiko Takeda Tags: Case reports Source Type: journals

Ziprasidone-related oculogyric crisis in an adultEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: To the best of our knowledge, this is the first report of ziprasidone-related OGC in an adult patient. Physicians must be aware of its occurrence in order to improve care of patients treated with these agents. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - November 4, 2009 Category: Neurosurgery Authors: Bernardo de Mattos Viana, Hugo Alejandro Cano Prais, Sarah Teixeira Camargos, Francisco Eduardo Costa Cardoso Tags: Case reports Source Type: journals

Characteristics of dystonia in the 18p deletion syndrome, including a new caseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Objective of the present study was to evaluate the possible pathophysiology and clinical characteristics of dystonia in patients with the 18p deletion syndrome by describing a new case and reviewing the literature. Dystonia in patients with the 18p deletion syndrome seems to present heterogeneously with a variable age of onset and distribution of symptoms. It may be accompanied with white matter lesions on the MRI. Deletion of 2 known dystonia loci on chromosome 18p, DYT7 and DYT15, or the deletion of another dystonia gene just above the centromere of chromosome 18p may be the cause of dystonia in patients with t...
Source: Clinical Neurology and Neurosurgery - November 4, 2009 Category: Neurosurgery Authors: Anna G. Postma, Corien C. Verschuuren-Bemelmans, Klaas Kok, Teus van Laar Tags: Case reports Source Type: journals

A case study of Neuro-psycho-Behçet's Syndrome presenting with psychotic attackEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Behçet's disease is a multisystem inflammatory disorder that presents with a classic triad of recurrent oral and genital ulcerations and uveitis with hypopyon. The initial symptom of Behçet's disease is neurological in only 3% of cases. Although Neuro-Behçet's Syndrome commonly presents with focal neurological symptoms, it is possible that psychiatric symptoms could be the first manifestation of the disease. To our knowledge, this is the first case report of Neuro-Behçet's Syndrome that presents with an acute psychotic attack. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - November 4, 2009 Category: Neurosurgery Authors: Orhan Deniz, Ali Çayköylü, Gönül Vural, Yakup Albayrak, Şadiye Temel, İsmail Aydın, Murat Kuloğlu Tags: Case reports Source Type: journals

Cervical spondylotic amyotrophy presenting as dropped head syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of acute-onset dropped head syndrome in a 65-year-old patient in whom the diagnosis of amyotrophic lateral sclerosis (ALS) was initially proposed based on electromyographic signs of neck and shoulder muscle denervation. There were no signs of pyramidal involvement and the clinical and electromyographic signs of motor denervation never evolved beyond the neck and shoulder girdle muscles after a 6-year follow-up period, which argued against ALS. Other causes of dropped head syndrome were carefully ruled out based on clinical findings, electrodiagnostic studies and blood investigations. The restriction of mus...
Source: Clinical Neurology and Neurosurgery - November 4, 2009 Category: Neurosurgery Authors: Rechdi Ahdab, Alain Créange, Sandrine Benaderette, Jean-Pascal Lefaucheur Tags: Case reports Source Type: journals

Successful endovascular reconstruction of acutely ruptured pseudoaneurysm of the vertebral artery, complicated by isolated vertebrobasilar circulation and symptomatic vasospasmEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: The management of a ruptured pseudoaneurysm of intracranial vertebral artery (VA), which is the sole supplier to an isolated vertebrobasilar system, is challenging. The authors report on such a case in a 49-year-old man who suffered a grade III subarachnoid hemorrhage (SAH) caused by a dissecting fusiform pseudoaneurysm of the left VA. The right VA terminated in the posterior inferior cerebellar artery and posterior communicating arteries were absent. The patient developed symptoms consistent with vasospasm on day 9 after SAH, which was treated by intra-arterial vasolytic therapy, followed by stent placement and ...
Source: Clinical Neurology and Neurosurgery - November 4, 2009 Category: Neurosurgery Authors: Shah-Naz Hayat Khan, Todd A. Abruzzo, Andrew J. Ringer Tags: Case reports Source Type: journals

Severe dopaminergic pathways damage in a case of chronic toluene abuseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Clinical and neuroradiological findings and the possible sensitivity to neuroleptics indicate dopaminergic impairment. Our case suggests that chronic toluene abuse causes presynaptic dopaminergic depletion. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - November 4, 2009 Category: Neurosurgery Authors: Sokratis G. Papageorgiou, Evgenia Karantoni, Dionysios Pandis, Anastasios V. Kouzoupis, Nikolaos Kalfakis, Georgios S. Limouris Tags: Case reports Source Type: journals

Spontaneous cerebral calcific embolus from the aortic archEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of stroke attributable to spontaneous calcific emboli from the aortic arch in which migration of the emboli was observed along the middle cerebral artery following iv tPA. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - November 4, 2009 Category: Neurosurgery Authors: Olga Acha, Francisco Novo, Belen Espina, Enrique Marco, Mariano Rebollo, Rafael Tejido Tags: Case reports Source Type: journals

Fractionated radiosurgical management of intramedullary spinal cord metastasis: A case report and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Fractionated stereotactic radiosurgery is a feasible, safe, and effective modality for the treatment of ICSM and should be carefully considered in the management of this difficult to treat condition. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - November 4, 2009 Category: Neurosurgery Authors: Simul Parikh, Dwight E. Heron Tags: Case reports Source Type: journals

Frontal lobe atrophy is associated with small vessel disease in ischemic stroke patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Frontal lobe atrophy in ischemic stroke patients may be associated with small vessel disease. The association between WMLs and FLA was predominant over atrophy of the parietal and temporal lobes, which suggests that the frontal lobe may be vulnerable to subcortical ischemic changes. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - November 4, 2009 Category: Neurosurgery Authors: Yangkun Chen, Xiangyan Chen, Weimin Xiao, Vincent C.T. Mok, Ka Sing Wong, Wai Kwong Tang Tags: Original articles Source Type: journals

Plasma level of sICAM-1 is associated with the extent of white matter lesion among asymptomatic elderly subjectsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Objective: Inflammatory endothelial activation mediated by intercellular adhesion molecule-1 (ICAM-1) plays a role in the pathogenesis of large- and small-vessel disease. We explored the association between soluble ICAM-1 (sICAM-1) and white matter lesion (WML) as a manifestation of cerebral small-vessel disease.Methods: One hundred and seventy-five elderly individuals aged ≥ 60 without neurological deficits were studied. Subcortical deep white matter hyperintensity (SDWMH) and periventricular hyperintensity (PVH) were rated separately. Lesions in each category were then divided into three groups (grade 0-I, gr...
Source: Clinical Neurology and Neurosurgery - November 4, 2009 Category: Neurosurgery Authors: Jing Hao Han, Ka Sing Wong, Yan Yan Wang, Jian Hui Fu, Ding Ding, Zhen Hong Tags: Original articles Source Type: journals

Intraoperative indocyanine green angiography in intracranial aneurysm surgery: Microsurgical clipping and revascularizationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: ICG angiography can provide real-time information and guide revision in the same surgical procedure for the management of intracranial aneurysms. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - November 4, 2009 Category: Neurosurgery Authors: Chi-Yuan Ma, Ji-Xin Shi, Han-Dong Wang, Chun-Hua Hang, Hui-Lin Cheng, Wei Wu Tags: Original articles Source Type: journals

Stereotactic brain biopsy: Single center retrospective analysis of complicationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Stereotactic brain biopsy is a safe and reliable way to obtain a histological diagnosis. Based on our recent clinical experiences, the data suggests that more attention should be paid to liver cirrhotic patients, since the chance on hemorrhage is significantly larger. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - November 4, 2009 Category: Neurosurgery Authors: Ching-Chang Chen, Peng-Wei Hsu, Tai-Wei Erich Wu, Shih-Tseng Lee, Chen-Nen Chang, Kuo-chen Wei, Chih-Cheng Chuang, Chieh-Tsai Wu, Tai-Ngar Lui, Yung-Hsin Hsu, Tzu-Kang Lin, Sai-Cheung Lee, Yin-Cheng Huang Tags: Original articles Source Type: journals

Evaluation of regional cerebral blood flow in cerebellar variant of multiple system atrophy using FineSRTEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: We suggest that a widespread brain involvement is present in patients with MSA-C and the decreased rCBF in the pons may support the differential diagnosis between MSA-C and LCCA. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - November 4, 2009 Category: Neurosurgery Authors: Noriyuki Kimura, Toshihide Kumamoto, Teruaki Masuda, Yuki Nomura, Takuya Hanaoka, Yusuke Hazama, Toshio Okazaki Tags: Original articles Source Type: journals

Cerebral microbleeds predict first-ever symptomatic cerebrovascular eventsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The presence of CMB is an independent predictor of first-ever symptomatic cerebrovascular diseases. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - November 4, 2009 Category: Neurosurgery Authors: Tomofumi Nishikawa, Tetsuya Ueba, Motohiro Kajiwara, Ichro Fujisawa, Naomi Miyamatsu, Kohsuke Yamashita Tags: Original articles Source Type: journals

The impact of fusion on adjacent levels in cervical spine injuries: Is it really important?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Adjacent-level ossification in cervical spine injuries may appear very early in the postoperative period and it can have a different course than in the degenerative disc disease population, at least in some patients. The first cephalad level adjacent to a fusion appears to be at greater risk. However, even when ALOD is evident radiographically, it very rarely produces any symptoms. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - November 4, 2009 Category: Neurosurgery Authors: Georgios B. Kasimatis, Sofia Michopoulou, Ioannis Boniatis, Panagiotis Dimopoulos, Georgios Panayiotakis, Elias Panagiotopoulos Tags: Original articles Source Type: journals

Prevalence of Parkinson's disease in Northern JordanEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: PD is a moderately prevalent disease in Jordan. The clinical characteristics of PD patients are similar to those reported in other countries. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - November 4, 2009 Category: Neurosurgery Authors: Ali Alrefai, Majed Habahbih, Mohammad Alkhawajah, Mohammad Darwish, Waleed Batayha, Yousef Khader, Khalid El-Salem Tags: Original articles Source Type: journals

Correlation of glioma proliferation assessed by flow cytometry with 99mTc-Tetrofosmin SPECT uptakeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Initial evidence suggests that 99mTc-TF could provide a non-invasive indicator of glioma proliferative activity. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - November 4, 2009 Category: Neurosurgery Authors: George A. Alexiou, Spyridon Tsiouris, George Vartholomatos, George Fotakopoulos, Athanasios Papadopoulos, Athanasios P. Kyritsis, Spyridon Voulgaris, Andreas D. Fotopoulos Tags: Original articles Source Type: journals

Treatment of deep vascular orbital malformationsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Treatment of vascular malformations is required in case of progression of symptoms. In cases of visual deterioration, we generally favour early treatment. The least invasive surgical approach, tailored to the individual patient, should be chosen. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - November 4, 2009 Category: Neurosurgery Authors: Uta Schick, Werner Hassler Tags: Original articles Source Type: journals

Ultrastructure and immunohistochemistry of the trigeminal peripheral myelinated axons in patients with neuralgiaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The pathological changes affect not only the central nerve fibers of the TNR, but also some of the peripheral axons, their myelin sheath and Schwann cells. These are signs of the retrograde ultrastructural and biochemical alterations, which could participate in the pathophysiological mechanism underlying the trigeminal neuralgia. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - November 4, 2009 Category: Neurosurgery Authors: Slobodan Marinković, Hirohiko Gibo, Vera Todorović, Branislav Antić, Dragoslava Kovačević, Milan Milisavljević, Mila Ćetković Tags: Original articles Source Type: journals

Machado-Joseph disease/SCA3 and myotonic dystrophy type 1 in a single patientEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report here, for the first time, the case of a 41-year-old man with both Machado-Joseph disease (MJD)/spinocerebellar ataxia type 3 (SCA3) and myotonic dystrophy type 1. The patient noted dysarthria at 14 years of age and unsteady gait at 30 years of age. Similar sized expansions of the CAG trinucleotide repeats in one allele of the ataxin-3 (ATXN3) gene were found in both the patient and his father, although in the other allele the length of the CAG repeats was shorter in the father compared with the patient. In the dystrophia myotonica protein kinase (DMPK) gene the CTG repeats were much more expanded in the patient c...
Source: Clinical Neurology and Neurosurgery - November 4, 2009 Category: Neurosurgery Authors: Shiroh Miura, Yasumasa Ohyagi, Taro Miike, Kazuhito Noda, Kyoko Motomura, Mitsuyoshi Ayabe, Hisamichi Aizawa, Takayuki Taniwaki Tags: Original articles Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - November 4, 2009 Category: Neurosurgery Source Type: journals

Excellent response to thrombolysis following prolonged basilar artery occlusion with extensive ischemic changes on MRIEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Mortality rates following acute basilar artery (BA) occlusion range between 50 and 95% . Recanalization of the BA with intra-arterial (IA) thrombolytic therapy has been shown to improve outcomes, particularly in selected patients treated within 24h of symptom onset . A number of features have been associated with poor outcome, including coma, tetraplegia and neuroimaging evidence of brainstem ischemia . We recently treated a patient who made an excellent recovery, despite the presence of all these prognostic features. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - October 5, 2009 Category: Neurosurgery Authors: Glen Jickling, James Scozzafava, Muhammad S. Hussain, Tom Yeo, Ken S. Butcher Tags: Letter to the Editor Source Type: journals

Paediatric intramedullary spinal cord cavernous malformations: Case report and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Cavernous malformations are vascular lesions which can occur throughout the entire neuraxis. This term is synonymous to cavernous angioma, cavernous haemangioma, and cavernoma. They comprise of closely packed, capillary-like vascular channels, without intervening neural tissue. MR imaging is currently the study of choice for the diagnosis of cavernous malformations as they are considered angiographically occult lesions. Intramedullary location represents only 3–5% of all central nervous system cavernous malformations, with the majority of them being supratentorial. Only 10% of the intramedullary cavernous malfo...
Source: Clinical Neurology and Neurosurgery - October 5, 2009 Category: Neurosurgery Authors: Angelos G. Kolias, Debasish Pal, Aditya Shivane, Azzam Ismail, Atul K. Tyagi Tags: Case reports Source Type: journals

Functional motor recovery of an infant after a huge ependymoma resectionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Huge supratentorial ependymomas are rarely encountered tumors, even in the infant population. A recovery from complete hemiplegia following a tumor resection including the primary motor cortex was observed.A 5-month-old girl presented with a conjugate deviation to the right and a head circumference that had gradually expanded since birth. Magnetic resonance imaging (MRI) demonstrated a well-enhanced huge mass extending into the right hemisphere. A subtotal removal with the primary motor cortex was performed. However, a regrowth of the residual tumor was observed and, thereafter, the patient underwent a subsequent...
Source: Clinical Neurology and Neurosurgery - October 5, 2009 Category: Neurosurgery Authors: Tatsuya Abe, Tohru Kamida, Yasutomo Momii, Mitsuhiro Anan, Hiroshi Ooba, Minoru Fujiki, Teruaki Mori Tags: Case reports Source Type: journals

Sellar neuroblastoma mimicking a pituitary tumour: Case report and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Neuroblastomas of the sellar region are exceedingly rare. Only 2 cases have previously been reported. Management of these tumours depends on the tumour's primary site, the patient's age and histopathological features. We are reporting the case of a 43-year-old woman who developed progressive bitemporal hemianopsia and visual loss, accompanied by amenorrhea and hyponatremia. Laboratory findings revealed a slightly elevated prolactin level. Cranial MR-imaging displayed an intrasellar and suprasellar lesion with a maximum diameter of 2.5cm that was suspicious for a pituitary adenoma or tuberculum sellae meningioma. ...
Source: Clinical Neurology and Neurosurgery - October 5, 2009 Category: Neurosurgery Authors: K. Schmalisch, T. Psaras, R. Beschorner, J. Honegger Tags: Case reports Source Type: journals

Primary intraventricular schwannomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Schwann cell tumors arising within the neuraxis and in an intraventricular location are an exceedingly rare tumor entity of the brain. The authors present the first case of a cellular intraventricular schwannoma occurring in the fourth ventricle. The pertinent literature is reviewed.A 71-year-old female was admitted to the hospital with an incidental finding of a ventricular tumor. Computed tomography scanning and magnetic resonance imaging revealed a solitary contrast enhancing exophytic mass lesion within the fourth ventricle. Microsurgical excision via a midline suboccipital craniotomy and tonsillo-nodular app...
Source: Clinical Neurology and Neurosurgery - October 5, 2009 Category: Neurosurgery Authors: Markus F. Oertel, Kay W. Nolte, Marcus Blaum, Joachim Weis, Joachim M. Gilsbach, Marcus C. Korinth Tags: Case reports Source Type: journals

Astasia, asymmetrical asterixis and pretectal syndrome in thalamo-mesencephalic hemorrhageEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a patient who presented with sudden onset instability and diplopia. On neurological examination he had asymmetrical asterixis, predominantly in the left hand, and ocular findings consistent with a pretectal syndrome. He was also unable to stand or even sit up unassisted, with a tendency to tilt his body and rotate his trunk axis to the left. Brain MRI showed a hemorrhage in the right thalamo-mesencephalic junction. This region involves important structures for the control of postural stability, motor control, ocular movements and vestibulo-ocular integration, not yet well understood. To our knowledge, this is the...
Source: Clinical Neurology and Neurosurgery - October 5, 2009 Category: Neurosurgery Authors: Eduardo de Pablo-Fernández, Alberto Villarejo, Cristina Domínguez-González, Fernando Sierra Hidalgo, Elisa Correas Callero Tags: Case reports Source Type: journals

Motor cortical epilepsia partialis continua in a patient with a localized sensory cortical lesionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We describe a 33-year-old man with cyclosporine encephalopathy who showed continuous jerking in the left upper limb due to epilepsia partialis continua. Jerk-locked back averaging (JLA) of magnetoencephalogram disclosed a spike preceding the jerk localized at the hand motor area, whereas JLA of electroencephalogram revealed no premyoclonus spikes. The paired-pulse motor cortical transcranial magnetic stimulation revealed motor cortical hyperexcitability, while the paired-pulse somatosensory evoked potential showed no sensory cortical hyperexcitability. The brain MRI showed a high intensity lesion localized at the hand sens...
Source: Clinical Neurology and Neurosurgery - October 5, 2009 Category: Neurosurgery Authors: Setsu Nakatani-Enomoto, Yasuo Terao, Ritsuko Hanajima, Shunichi Matsuda, Shinya Ohminami, Satomi Inomata-Terada, Hideyuki Matsumoto, Akihiro Yugeta, Tomotaka Yamamoto, Jun Goto, Masato Yumoto, Shoji Tsuji, Yoshikazu Ugawa Tags: Case reports Source Type: journals

Diagnosis and surgical management of extracranial PICA aneurysms presenting through subarachnoid haemorrhage: Case report and review of the literatureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The present report underscores the anatomical variants of the PICA. Although uncommon, PICA aneurysms do occur and caretakers should be aware of this when treating patients with clinical signs or CT evidence of subarachnoid haemorrhage. Even extracranial PICA aneurysms can be encountered, either through a caudal loop or an early extracranial lateral medullary segment. We stress the use of four vessel angiography or CT angiography with thin cuts to rule out such aneurysms. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - October 5, 2009 Category: Neurosurgery Authors: Ruben Dammers, Ali F. Krisht, Sharon Partington Tags: Case reports Source Type: journals

Upper extremity motor measures of Tap Test response in Normal Pressure HydrocephalusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Objective: The Tap Test (TT) is a commonly used method for predicting shunt responsiveness in patients with Normal Pressure Hydrocephalus (NPH). The present study investigates whether measures of upper extremity motor function are useful for assessing response to spinal fluid drainage.Methods: 42 subjects undergoing evaluations for idiopathic NPH (iNPH) participated in this study. A standardized gait evaluation, a neuropsychological battery, and objective tests of upper extremity motor functions were administered. A Neurologist skilled in NPH assessment independently rated patients as TT Responders (n=26) or Non-...
Source: Clinical Neurology and Neurosurgery - October 5, 2009 Category: Neurosurgery Authors: Diamanto Tsakanikas, Heather Katzen, Lisa D. Ravdin, Norman R. Relkin Tags: Original articles Source Type: journals

Efficacy of temozolomide as adjuvant chemotherapy after postsurgical radiotherapy alone for glioblastomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Adjuvant TMZ chemotherapy provided a clinically relevant benefit of survival, as compared with NUBC. Thus, we suggest that adjuvant TMZ chemotherapy may be effective even for patients who did not receive concomitant chemoradiotherapy for GBM. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - October 5, 2009 Category: Neurosurgery Authors: Deok-Joo Rhee, Doo-Sik Kong, Won Seog Kim, Kwon-Byong Park, Jung-Il Lee, Yeon-Lim Suh, Sang Young Song, Sung Tae Kim, Do-Hoon Lim, Kwan Park, Jong Hyun Kim, Do-Hyun Nam Tags: Original articles Source Type: journals

A multicentre retrospective study of the clinical use of ropinirole in the treatment of Parkinson's disease: The ROPI-PARK StudyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The low incidence of adverse reactions and low rate of treatment withdrawal observed in this study support the effectiveness and tolerability of RPN in the treatment of Parkinson's disease. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - October 5, 2009 Category: Neurosurgery Authors: F. Valldeoriola, S. Cobaleda, J. Lahuerta Tags: Original articles Source Type: journals

Female gender but not cigarette smoking delays the onset of Parkinson's diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Our results suggest that females have a delayed onset of symptoms, possibly related to the gonadotropin profile of our population upon the nigrostriatal dopaminergic system. The effect of low educational level may be related to a delayed diagnosis, rather than a true delay of disease onset. This report suggests an influence of gender on the onset of Parkinson's disease. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - October 5, 2009 Category: Neurosurgery Authors: Abelardo Martínez-Rumayor, Oscar Arrieta, Julio Sotelo, Esperanza García Tags: Original articles Source Type: journals

Depressive symptoms impacting on health-related quality of life in early Parkinson's disease: Results from Chinese l-dopa exposed cohortEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Objective: To investigate the impact of depressive symptoms on health-related quality of life (HR-QOL) in a group of patients with early Parkinson's disease (PD).Methods: A 20-item scale, the Center for Epidemiologic Studies Depression Scale (CESD) and a 36-item questionnaire, the medical outcomes study short form (SF-36) were administered as part of baseline assessment of a clinical trial in PD, enrolling 391 early-stage, l-dopa exposed PD patients in China. We used multiple regression models to examine the relationship of depressive symptoms, measured by the CESD with HR-QOL, as measured by the SF-36. The SF-36...
Source: Clinical Neurology and Neurosurgery - October 5, 2009 Category: Neurosurgery Authors: Zhaohui Qin, Liyan Zhang, Fei Sun, Hongjun Liu, Xianghua Fang, Piu Chan, the Chinese Parkinson Study Group Tags: Original articles Source Type: journals

Do women benefit more from systemic thrombolysis in acute ischemic stroke? A Serbian experience with thrombolysis in ischemic stroke (SETIS) studyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: There were no sex differences in functional outcome at 90 days after the stroke among patients treated with IV rtPA. This finding might confirm that thrombolytic therapy nullifies usual sex differences in stroke outcome and suggests that women with stroke may benefit more from rtPA treatment. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - October 5, 2009 Category: Neurosurgery Authors: D.R. Jovanović, Lj. Beslać-Bumbaširević, M. Budimkić, T. Pekmezović, M. Živković, V.S. Kostić, for the SETIS Investigation Group Tags: Original articles Source Type: journals

Serum uric acid levels in patients with Parkinson's disease: Their relationship to treatment and disease durationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: There is evidence to support that oxidative stress is increased in Parkinson's disease (PD) and contributes to degeneration of dopaminergic neurons. Uric acid (UA), a natural antioxidant in blood and brain tissue, scavenging superoxide, peroxynitrite and hydroxyl radical, was found reduced in the serum of PD patients. In addition low plasma uric acid (UA) levels have been associated with an increased risk of PD.Objectives: The aim of our study was to investigate serum UA levels in PD patients compared with age-matched healthy controls and their possible relationship with several clinical parameters of PD and phar...
Source: Clinical Neurology and Neurosurgery - October 5, 2009 Category: Neurosurgery Authors: Elisabeth Andreadou, Chryssoula Nikolaou, Filippos Gournaras, Michael Rentzos, Fotini Boufidou, Anthoussa Tsoutsou, Christos Zournas, Vassilis Zissimopoulos, Demetrios Vassilopoulos Tags: Original articles Source Type: journals

Interobserver variability in the detection of cerebral venous thrombosis using CT venography with matched mask bone eliminationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: CTV aided with MMBE is a robust technique for visualization of the intracranial venous circulation, removing bone effectively. CTV has high interobserver agreement for presence or absence of cerebral venous thrombosis. (Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - October 5, 2009 Category: Neurosurgery Authors: Hugo A. Gratama van Andel, Leonard J. van Boven, Marianne A. van Walderveen, Henk W. Venema, Jeroen C. van Rijn, Jan Stam, Cornelis A. Grimbergen, Gerard J. den Heeten, Charles B. Majoie Tags: Original articles Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical Neurology and Neurosurgery)
Source: Clinical Neurology and Neurosurgery - October 5, 2009 Category: Neurosurgery Source Type: journals

Isolated homonymous hemianopsia due to lateral posterior choroidal artery region infarction: A case reportEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: An 86-year-old, right-handed, hypertensive man suddenly experienced blurring of vision predominating in the left visual field. Neurological examinations were normal, except for left homonymous hemianopsia. Goldmann visual field testing revealed a left congruent incomplete homonymous hemianopsia with macular splitting. Brain MRI, with a T2-weighted image, demonstrated a lesion of high intensity in the right lateral geniculate body (LGB), as well as the posterior part of the caudate nucleus, posterolateral thalamus, and dorsolateral thalamus. MRA revealed severe stenosis at the second segment of right posterior cer...
Source: Clinical Neurology and Neurosurgery - August 27, 2009 Category: Neurosurgery Authors: Koichi Shibata, Yoshiko Nishimura, Hiromi Kondo, Kuniaki Otuka, Makoto Iwata Tags: Case reports Source Type: journals

Stiff person syndrome associated with lower motor neuron disease and infiltration of cytotoxic T cells in the spinal cordEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a 67-year-old non-diabetic male who presented with muscle cramps, paresis, atrophy and fasciculations in the left leg, followed by rapidly progressive muscle stiffness and superimposed spasms which subsequently also affected the right leg and the trunk. GAD65 autoantibodies were elevated in serum and CSF, compatible with systemic and intrathecal synthesis of oligoclonal and high-avidity autoantibodies, and GAD65 specific T cells were clonally expanded in the CSF. The patient did not respond to GABAergic and immunomodulatory treatment or plasma exchange, and died from respiratory failure after 18 months. Autopsy ...
Source: Clinical Neurology and Neurosurgery - August 27, 2009 Category: Neurosurgery Authors: Trygve Holmøy, Gjertrud Skorstad, Line Sveberg Røste, David Scheie, Kirsti Alvik Tags: Case reports Source Type: journals