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Non-zero mean and asymmetry of neuronal oscillations have different implications for evoked responses.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Our findings indicate that it is the non-zero mean of neuronal oscillations, and not an amplitude asymmetry of peaks and troughs, that is a prerequisite for the generation of evoked responses through a mechanism of amplitude modulation of oscillations. SIGNIFICANCE: A clear distinction should be made between the shape and non-zero mean properties of neuronal oscillations. This is because only the latter contributes to evoked responses, whereas the former does not. PMID: 19914864 [PubMed - as supplied by publisher] (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - November 13, 2009 Category: Neurology Authors: Nikulin VV, Linkenkaer-Hansen K, Nolte G, Curio G Tags: Clin Neurophysiol Source Type: journals

The time course of temporal discrimination: An ERP study.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: ERP components associated with the offset of the comparison intervals clarified the involvement of working memory processes and different brain structures in temporal discrimination. SIGNIFICANCE: This study further improves our understanding of the cognitive processes and neural substrates underlying temporal discrimination in healthy subjects and lays the ground for the investigation of clinical samples with time processing deficits. PMID: 19914865 [PubMed - as supplied by publisher] (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - November 13, 2009 Category: Neurology Authors: Tarantino V, Ehlis AC, Baehne C, Boreatti-Huemmer A, Jacob C, Bisiacchi P, Fallgatter AJ Tags: Clin Neurophysiol Source Type: journals

Effects of aging on the human motor cortical plasticity studied by paired associative stimulation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: These results suggest that the human M1 shows age-dependent reduction of cortical plasticity. SIGNIFICANCE: The reduction of the M1 plasticity may be caused by the attenuated responsiveness of intracortical circuits in the M1 and/or disrupted sensorimotor integration within basal ganglia-thalamocortical loop. PMID: 19910248 [PubMed - as supplied by publisher] (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - November 10, 2009 Category: Neurology Authors: Fathi D, Ueki Y, Mima T, Koganemaru S, Nagamine T, Tawfik A, Fukuyama H Tags: Clin Neurophysiol Source Type: journals

Partial seizures are associated with early increases in signal complexity.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Partial onset seizures are associated with early increases in signal complexity as measured by GAD. This increase is independent of the location of the seizure focus. SIGNIFICANCE: Despite the often predominant rhythmic activity that characterizes onset and early evolution of epileptic seizures, partial seizure onset is associated with an early increase in complexity. These changes are common to partial seizures originating from different brain regions, indicating a similar seizure dynamic. PMID: 19910249 [PubMed - as supplied by publisher] (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - November 10, 2009 Category: Neurology Authors: Jouny CC, Bergey GK, Franaszczuk PJ Tags: Clin Neurophysiol Source Type: journals

Surround inhibition is modulated by task difficulty.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: We conclude that SI occurs earlier and stronger with increasing task difficulty. SIGNIFICANCE: The timing as well as the bilateral effect of the inhibition suggests that motor areas involved in motor planning, proximate to the motor cortex, contribute to the genesis of surround inhibition. PMID: 19906559 [PubMed - as supplied by publisher] (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - November 10, 2009 Category: Neurology Authors: Beck S, Hallett M Tags: Clin Neurophysiol Source Type: journals

How are evoked responses generated? The need for a unified mathematical framework Editorial comments on "Non-zero mean and asymmetry of neuronal oscillations have different implications for evoked responses" by Nikulin V, Linkenkaer-Hansen K, Nolte G and Curio G.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19903590 [PubMed - as supplied by publisher] (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - November 9, 2009 Category: Neurology Authors: Munck JC, Bijma F Tags: Clin Neurophysiol Source Type: journals

Age-related changes in postural responses revealed by support-surface translations with a long acceleration-deceleration interval.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: LONG compared to SHORT surface translations magnify the age-related kinematic but not the EMG changes in reactive postural control. The anticipatory component of postural control was not affected by age. SIGNIFICANCE: Translations with longer acceleration-deceleration intervals reveal more age-related differences in postural control, which are otherwise masked by the deceleration effects inherent to shorter translations. PMID: 19903591 [PubMed - as supplied by publisher] (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - November 9, 2009 Category: Neurology Authors: Tokuno CD, Cresswell AG, Thorstensson A, Carpenter MG Tags: Clin Neurophysiol Source Type: journals

Ocular-jaw synkinesia in normal, Parkinson's disease, and multiple system atrophy subjects: Clinical and electrophysiological findings.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: OJS is a normal and common synkinetic cranial movement easy to observe in PD and normal subjects on both physical and electrophysiological examinations. In contrast, the MSA-p patients showed no physical or electrophysiological signs of OJS in this study. SIGNIFICANCE: The presence of OJS is supportive of the clinical diagnosis of PD; its absence is uncommon in PD and may suggest an alternative Parkinsonism such as MSA-p. PMID: 19906558 [PubMed - as supplied by publisher] (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - November 9, 2009 Category: Neurology Authors: Salazar G, Casas E, Oliveras D, Rando A, Sergio P Tags: Clin Neurophysiol Source Type: journals

Lateralization of forelimb motor evoked potentials by transcranial magnetic stimulation in rats.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: We demonstrate that lateralized TMS leading to asymmetric brachioradialis activation is feasible with conventional TMS equipment in anesthetized rats. SIGNIFICANCE: These data show that TMS can be used to assess the unilateral excitability of the forelimb descending motor pathway in the rat, and suggest that rat TMS protocols analogous to human TMS may be applied in future translational research. PMID: 19900839 [PubMed - as supplied by publisher] (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - November 7, 2009 Category: Neurology Authors: Rotenberg A, Muller PA, Vahabzadeh-Hagh AM, Navarro X, López-Vales R, Pascual-Leone A, Jensen F Tags: Clin Neurophysiol Source Type: journals

Event-related components of the punishment and reward sensitivity.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: The FRN was sensitive to cues of punishment and higher BIS was uniquely related to a larger FRN amplitude on No-Go/Loss trials, linking BIS with conflict monitoring and sensitivity to No-Go cues. Furthermore, the significant interaction found between BIS and RR on FRN amplitude together with the findings linking High-RR levels with shorter RTs, smaller P3 amplitudes and enhanced positive feelings are in line with the hypothesis that both BIS and BAS have the potential to influence punishment-mediated and reward-mediated behaviour. SIGNIFICANCE: Results open up new perspectives for future investigations on the r...
Source: Clinical Neurophysiology - November 7, 2009 Category: Neurology Authors: De Pascalis V, Varriale V, D'Antuono L Tags: Clin Neurophysiol Source Type: journals

When is electrical cortical stimulation more likely to produce afterdischarges?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: ADs were more likely to occur when an electrode pair showed ADs and was stimulated again, especially when stimulating after short inter-trial intervals or for longer duration. SIGNIFICANCE: When ADs occur, waiting about a minute before resuming stimulation might lessen the likelihood of AD recurrence. PMID: 19900841 [PubMed - as supplied by publisher] (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - November 7, 2009 Category: Neurology Authors: Lee HW, Webber WR, Crone N, Miglioretti DL, Lesser RP Tags: Clin Neurophysiol Source Type: journals

Sound conclusions?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19897411 [PubMed - as supplied by publisher] (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - November 6, 2009 Category: Neurology Authors: Colebatch JG Tags: Clin Neurophysiol Source Type: journals

A critical review of the neurophysiological evidence underlying clinical vestibular testing using sound, vibration and galvanic stimuli.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In addition to activating cochlear receptors, air conducted sound (ACS) and bone conducted vibration (BCV) activate vestibular otolithic receptors, as shown by neurophysiological evidence from animal studies - evidence which is the foundation for using ACS and BCV for clinical vestibular testing by means of vestibular-evoked myogenic potentials (VEMPs). Recent research is elaborating the specificity of ACS and BCV on vestibular receptors. The evidence that saccular afferents can be activated by ACS has been mistakenly interpreted as showing that ACS only activates saccular afferents. That is not correct - ACS activates...
Source: Clinical Neurophysiology - November 6, 2009 Category: Neurology Authors: Curthoys IS Tags: Clin Neurophysiol Source Type: journals

Emotional MMN: Anxiety and heart rate correlate with the ERP signature for auditory change detection.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSION: Taken together, these results suggest that the pre-attentive processing of threat, as reflected by the MMN, is linked to an activation of the sympathetic nervous system. Moreover, this link is more strongly activated in individuals with high state anxiety. SIGNIFICANCE: Thus, the MMN may be used as a marker for an individual's state dependent sensitivity to unattended, emotionally relevant change. PMID: 19896894 [PubMed - as supplied by publisher] (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - November 5, 2009 Category: Neurology Authors: Schirmer A, Escoffier N Tags: Clin Neurophysiol Source Type: journals

Frequency-tuning characteristics of cervical and ocular vestibular evoked myogenic potentials induced by air-conducted tone bursts.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Ocular VEMP showed the similar frequency tuning to cervical VEMP. Cervical VEMP responses showed higher incidence, lower thresholds and larger amplitudes than ocular VEMP. SIGNIFICANCE: Cervical VEMP is a more reliable measure than ocular VEMP, though the results of both tests will be complementary. Five hundred Hertz is the optimal frequency to use. PMID: 19892592 [PubMed - as supplied by publisher] (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - November 3, 2009 Category: Neurology Authors: Park HJ, Lee IS, Shin JE, Lee YJ, Park MS Tags: Clin Neurophysiol Source Type: journals

Neurostimulation therapy (acupuncture-like) and long-term depression: A challenge for the clinical neurophysiologist.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19892593 [PubMed - as supplied by publisher] (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - November 3, 2009 Category: Neurology Authors: Cruccu G, Truini A Tags: Clin Neurophysiol Source Type: journals

Periodic limb movements both in non-REM and REM sleep. A response to Drs. Manconi, Ferri and Ferini-StrambiEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Periodic and non-periodic limb movements during sleep (PLMS/LMS) are object of a number of recent studies involving various aspects concerning their epidemiology, pathogenesis, clinical characteristics and relationships with other sleep disorders. In their commentary to our study (), Manconi, Ferri and Ferini Strambi stress the importance of a standard methodological approach and of the recruitment of homogeneous study samples to go deeper into this item and enable generalization of results. Manconi and cohautors raise some points concerning the characteristics of the sample analyzed in our study, in which PLMS index in no...
Source: Clinical Neurophysiology - November 1, 2009 Category: Neuroscience Authors: M. Allena, E. Morrone, F. De Carli, S. Garbarino, C. Manfredi, D. Rossi-Sebastiano, C. Campus Tags: Letters to the Editor Source Type: journals

A commentary on “Periodic limb movements both in non-REM and in REM sleep: Relationships between cerebral and autonomic activities” by Allena et al. Clin Neurophysiol 2009;120:1282–90Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In the July 2009 issue of Clinical Neurophysiology, Allena et al. deal with one of the most intriguing and still unresolved sleep-related motor phenomenon represented by the periodic limb movements during sleep (PLMS) and their relationship with autonomic and cortical arousals. () The authors performed a careful investigation on the temporal relationship between these three associated polysomnographic periodic events, finding that the autonomic component (heart rate – HR) increase generally preceded the cortical and motor events, and that cortical EEG activations preceded PLMS only during NREM sleep. (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - November 1, 2009 Category: Neuroscience Authors: M. Manconi, R. Ferri, L. Ferini-Strambi Tags: Letters to the Editor Source Type: journals

Investigation of cue-based vertical and horizontal eye movements with electroencephalographic and eye-tracking dataEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The fact that eye movements are correlated with a desynchronization of activity in parietal and occipital areas is reasonable, since visual information processing and visual control of movements take place there. Stronger ERD in the alpha band could be related to the fact that information processing tasks like e.g. reading require mostly horizontal and not vertical eye movements.Significance: The differences in the ERD/ERS patterns in relation to the direction of the eye movement should be considered in future investigations and taken into account in the construction of paradigms. (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - November 1, 2009 Category: Neuroscience Authors: Vera Kaiser, Clemens Brunner, Robert Leeb, Christa Neuper, Gert Pfurtscheller Tags: Original Research Articles Source Type: journals

Spatial detection of multiple movement intentions from SAM-filtered single-trial MEG signalsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Multiple movement intentions can be reliably detected from SAM-based spatially filtered single-trial MEG signals.Significance: MEG signals associated with natural motor behavior may be utilized for a reliable high-performance brain–computer interface (BCI) and may reduce long-term training compared with conventional BCI methods using rhythm control. (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - November 1, 2009 Category: Neuroscience Authors: Harsha Battapady, Peter Lin, Tom Holroyd, Mark Hallett, Xuedong Chen, Ding-Yu Fei, Ou Bai Tags: Original Research Articles Source Type: journals

Determinants of double discharges in amyotrophic lateral sclerosis and Kennedy diseaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Objective: Double discharges (DDs) of the motor unit are frequent in amyotrophic lateral sclerosis (ALS) and Kennedy’s disease (KD). This likely reflects changes in the intrinsic properties of motor neurons but in ALS changes in corticomotoneuronal inputs may also contribute. We determined the corticomotoneuronal contribution to DDs.Methods: DD prevalence, intra-doublet interval (IDI) of DDs and their timing with respect to transcranial magnetic stimulation (TMS)-induced primary peaks (PPs) in the peristimulus time histogram (PSTH) were measured in 23 ALS patients (96 motor units), 11 patients with KD (45 motor...
Source: Clinical Neurophysiology - November 1, 2009 Category: Neuroscience Authors: Markus Weber, Vanessa Ferreira, Andrew Eisen Tags: Original Research Articles Source Type: journals

MEG’s ability to localise accurately weak transient neural sourcesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: MEG can detect and localise weak transient activations and the human HFO with an accuracy of a few mm at cortical and subcortical regions even when a small number of trials are used.Significance: Localizing HFO to specific anatomical structures has high clinical utility, for example in epilepsy, where discrete HFO appears to be generated just before focal epileptic activity. (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - November 1, 2009 Category: Neuroscience Authors: Christos Papadelis, Vahe Poghosyan, Peter B.C. Fenwick, Andreas A. Ioannides Tags: Original Research Articles Source Type: journals

The relationship between preattentive sensory processing deficits and age in schizophrenia patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: In our cohort of schizophrenia patients, MMN and P3a deficits were already present at the youngest ages. MMN declined further with age, whereas P3a amplitude remained stable.Significance: This knowledge about how MMN and P3a amplitudes vary with age in schizophrenia patients compared to NCPs can help improve the utility of these indices as clinical endophenotypes or biomarkers. (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - November 1, 2009 Category: Neuroscience Authors: Michael Kiang, David L. Braff, Joyce Sprock, Gregory A. Light Tags: Original Research Articles Source Type: journals

Functional topography of the ventral striatum and anterior limb of the internal capsule determined by electrical stimulation of awake patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Acute behavioral and subjective responses can be consistently obtained from stimulation in the ventral ALIC and VS region. Positive changes in mood and anxiety were reproducibly elicited in the ventral ALIC area.Significance: Intraoperative awake stimulation and postoperative programming of patients undergoing DBS for MDD provide unique opportunities to explore the subjective responses and behavioral phenomena related to electrical stimulation of the area spanning from the dorsal ALIC to the ventral striatum. (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - November 1, 2009 Category: Neuroscience Authors: Andre Machado, Suzanne Haber, Nathaniel Sears, Benjamin Greenberg, Donald Malone, Ali Rezai Tags: Original Research Articles Source Type: journals

Classification of patterns of EEG synchronization for seizure predictionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our best machine learning technique applied to spatio-temporal patterns of EEG synchronization outperformed previous seizure prediction methods on the Freiburg dataset.Significance: By learning spatio-temporal dynamics of EEG synchronization, pattern recognition could capture patient-specific seizure precursors. Further investigation on additional datasets should include the seizure prediction horizon. (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - November 1, 2009 Category: Neuroscience Authors: Piotr Mirowski, Deepak Madhavan, Yann LeCun, Ruben Kuzniecky Tags: Original Research Articles Source Type: journals

Abnormal auditory cortex with giant N100m signal in patients with autosomal dominant lateral temporal lobe epilepsyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Unilateral cortical abnormality exists in some of the patients in ADLTE. Patients with abnormally large N100m had seizures apparently provoked by auditory stimuli, suggesting that the appearance of significantly large N100m is associated with the epileptogenicity. Based on the detailed examination using MRI and FDG-PET for two of the patients, the authors hypothesize hyperexcitability caused by the decreased inhibitory functions, larger number of synchronously activated neurons, or the elongation of neuronal firing in the pathological temporal cortex in ADLTE.Significance: The present study revealed clear abno...
Source: Clinical Neurophysiology - November 1, 2009 Category: Neuroscience Authors: Keiko Usui, Akio Ikeda, Takashi Nagamine, Jun Matsubayashi, Riki Matsumoto, Harukazu Hiraumi, Jun Kawamata, Masao Matsuhashi, Ryosuke Takahashi, Hidenao Fukuyama Tags: Original Research Articles Source Type: journals

Detection of subclinical electroencephalographic seizure patterns with multichannel amplitude-integrated EEG in full-term neonatesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Seizure pattern detection rate is slightly better with multichannel aEEG compared with single-channel (C4–C3) aEEG. Multichannel aEEG identified correctly all patients with ⩾1 seizure pattern in this small selection of patients.Significance: Single-channel aEEG may detect most patients (in a selected group) with severe neonatal seizures patterns; patient identification can be improved using multichannel recordings. (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - November 1, 2009 Category: Neuroscience Authors: Mireille D. Bourez-Swart, Linda van Rooij, Cristiano Rizzo, Linda S. de Vries, Mona C. Toet, Tineke A. Gebbink, Anja G.J. Ezendam, Alexander C. van Huffelen Tags: Original Research Articles Source Type: journals

Computerized epileptiform transient detection in the scalp electroencephalogram: Obstacles to progress and the example of computerized ECG interpretationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Computerized detection of epileptiform transients (ETs), also called spikes and sharp waves, in the electroencephalogram (EEG) has been a research goal for the last 40years. A reliable method for detecting ETs could improve efficiency in reviewing long EEG recordings and assist physicians in interpreting routine EEGs. Computer algorithms developed so far for detecting ETs are not as reliable as human expert interpreters, mostly due to the large number of false positive detections. Typical methods for ET detection include measuring waveform morphology, detecting signal non-stationarity, and power spectrum analysis...
Source: Clinical Neurophysiology - November 1, 2009 Category: Neuroscience Authors: Jonathan J. Halford Tags: Invited Review Source Type: journals

Event-related potentials in clinical research: Guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: This paper describes recommended methods for the use of event-related brain potentials (ERPs) in clinical research and reviews applications to a variety of psychiatric and neurological disorders. Techniques are presented for eliciting, recording, and quantifying three major cognitive components with confirmed clinical utility: mismatch negativity (MMN), P300, and N400. Also highlighted are applications of each of the components as methods of investigating central nervous system pathology. The guidelines are intended to assist investigators who use ERPs in clinical research, in an effort to provide clear and conci...
Source: Clinical Neurophysiology - November 1, 2009 Category: Neuroscience Authors: Connie C. Duncan, Robert J. Barry, John F. Connolly, Catherine Fischer, Patricia T. Michie, Risto Näätänen, John Polich, Ivar Reinvang, Cyma Van Petten Tags: Guidelines Source Type: journals

Corticomotoneuronal dysfunction: A process specific to amyotrophic lateral sclerosis?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Amyotrophic lateral sclerosis [ALS] is a universally fatal neurodegenerative disorder of motor neurons in the spinal cord, brainstem and cortex (). Fasciculations and double discharges, defined as occurrence of two consecutive motor unit discharges of similar shape and amplitude, separated by a short intespike interval and occurring during motor unit activation, are a common feature of ALS, taken to reflect ectopic activity of motor axons (). The origin of such ectopic activity remains a matter of debate, with both the motor nerve terminal and anterior horn cell () proposed as potential generator sites. (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - November 1, 2009 Category: Neuroscience Authors: Steve Vucic Tags: Editorials Source Type: journals

Beyond “Poke & Hope”: The next steps for DBS for psychiatric disordersEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The effort to apply Deep Brain Stimulation (DBS) in the realm of psychiatric disease is the most prominent frontier in functional neurosurgery today. A vast patient population with an unmet need certainly is the main factor in driving these efforts. However, it is the unique nature of the technique of DBS that is allowing these efforts to move forward despite the nefarious past of neurological surgery for psychiatric disorders has. DBS, with its inherently reversible nature allows a degree of safety that stereotactic lesions do not possess. Furthermore, the ability to program DBS systems in situ allows a degree of freedom ...
Source: Clinical Neurophysiology - November 1, 2009 Category: Neuroscience Authors: Brian Harris Kopell, Jerry Halverson Tags: Editorials Source Type: journals

Clinical ERPs: From consternation toward elucidationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Perhaps you’ve had the following experience. You’re reviewing an area of the ERP literature and find a bimodal distribution of study outcomes. Two distinct camps exist, each conducting seemingly tight studies, but yielding outcomes that are incompatible. Looking further you discover that the ERP waveforms and topographic distributions studied by the two groups bear little resemblance to one another. Digging still deeper into their experimental methods, you find that a small, but consistent methodological difference underlies the contradictory outcomes. (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - November 1, 2009 Category: Neuroscience Authors: Kerry L. Coburn Tags: Editorials Source Type: journals

Editorial BoardEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - November 1, 2009 Category: Neuroscience Source Type: journals

ContentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - November 1, 2009 Category: Neuroscience Source Type: journals

Transition from cortical slow oscillations of sleep to spike-wave seizures.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The initial discharges of each seizure engaged both the left frontal pole, which was the primary neural source of this patient's CSOs, and the left temporal lobe, which seemed critical for the evolution of this patient's seizures. SIGNIFICANCE: The correlation of SW seizures with CSOs in animal studies may be observed in humans as well, providing clues to the pathology of arousal regulation in some cases of nocturnal epilepsy. PMID: 19879188 [PubMed - as supplied by publisher] (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - October 28, 2009 Category: Neurology Authors: Tucker DM, Waters AC, Holmes MD Tags: Clin Neurophysiol Source Type: journals

Motor excess during movement: Overflow, mirroring, and synkinesis.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19875335 [PubMed - as supplied by publisher] (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - October 28, 2009 Category: Neurology Authors: Espay AJ Tags: Clin Neurophysiol Source Type: journals

Cortical neural plasticity in aged human brains.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19875334 [PubMed - as supplied by publisher] (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - October 27, 2009 Category: Neurology Authors: Oliviero A Tags: Clin Neurophysiol Source Type: journals

Neurophysiological changes with age probed by inverse modeling of EEG spectra.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Mean-field brain modeling allows interpretation of age-associated EEG trends in terms of physiological processes, including the growth and regression of white matter, influencing axonal delays, and the establishment and pruning of synaptic connections, influencing gains. SIGNIFICANCE: This study demonstrates the feasibility of inverse modeling of EEG spectra as a noninvasive method for investigating large-scale corticothalamic dynamics, and provides a basis for future comparisons. PMID: 19854102 [PubMed - as supplied by publisher] (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - October 22, 2009 Category: Neurology Authors: van Albada SJ, Kerr CC, Chiang AK, Rennie CJ, Robinson PA Tags: Clin Neurophysiol Source Type: journals

A patient with a transient photomyogenic response.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19854103 [PubMed - as supplied by publisher] (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - October 22, 2009 Category: Neurology Authors: Stegge BM, Putten MJ Tags: Clin Neurophysiol Source Type: journals

Holes in the head.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19853502 [PubMed - as supplied by publisher] (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - October 21, 2009 Category: Neurology Authors: Lesser RP Tags: Clin Neurophysiol Source Type: journals

Put the right person in the right place: Segmental evaluation of the peripheral nerve for a diagnosis of CIDP.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19853503 [PubMed - as supplied by publisher] (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - October 21, 2009 Category: Neurology Authors: Kuwabara S Tags: Clin Neurophysiol Source Type: journals

Homotopic long-term depression of trigeminal pain and blink reflex within one side of the human face.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Trigeminal nociception and pain were inhibited by homotopic LFS at the forehead but not after heterotopic LFS of infraorbital and mental nerve skin afferents. SIGNIFICANCE: Homotopic organization of ipsilateral trigeminal LTD in man may have implications for future neuromodulatory treatment of chronic craniofacial pain. PMID: 19853504 [PubMed - as supplied by publisher] (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - October 21, 2009 Category: Neurology Authors: Aymanns M, Yekta SS, Ellrich J Tags: Clin Neurophysiol Source Type: journals

Mechanisms involved in the conduction of anterior temporal epileptiform discharges to the scalp.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The topography of anterior temporal discharges is most readily explained by volume conduction through high conductivity skull foramina. SIGNIFICANCE: The role of skull holes should be incorporated in EEG and possibly in MEG source localisation models and additional facial electrodes can be useful in the evaluation of bitemporal discharges in temporal lobe epilepsy. PMID: 19850514 [PubMed - as supplied by publisher] (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - October 20, 2009 Category: Neurology Authors: Sparkes M, Valentin A, Alarcón G Tags: Clin Neurophysiol Source Type: journals

Segmental evaluation of the peripheral nerve using tibial nerve SEPs for the diagnosis of CIDP.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Tibial nerve SEPs were highly sensitive and specific, at least in comparison with DPN, measures for the diagnosis of CIDP. SIGNIFICANCE: Segmental evaluation of the peripheral nerve using tibial nerve SEPs is expected as a promising tool to document proximal-dominant involvement in CIDP. PMID: 19850515 [PubMed - as supplied by publisher] (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - October 20, 2009 Category: Neurology Authors: Tsukamoto H, Sonoo M, Shimizu T Tags: Clin Neurophysiol Source Type: journals

Multifocal frequency-doubling pattern visual evoked responses to dichoptic stimulation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: The results indicated that dichoptic evoked potentials using multifocal frequency-doubling illusion stimuli are practical. The use of crossed orientation, or differing spatial frequencies, in the two eyes reduced binocular interactions. SIGNIFICANCE: The results indicate a method wherein several spatial or temporal and frequencies per visual field region can be tested in reasonable time using a multifocal VEP using spatial frequency-doubling stimuli. PMID: 19846337 [PubMed - as supplied by publisher] (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - October 18, 2009 Category: Neurology Authors: Rosli Y, Maddess T, Dawel A, James AC Tags: Clin Neurophysiol Source Type: journals

Classification of patterns of EEG synchronization for seizure prediction.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: Our best machine learning technique applied to spatio-temporal patterns of EEG synchronization outperformed previous seizure prediction methods on the Freiburg dataset. SIGNIFICANCE: By learning spatio-temporal dynamics of EEG synchronization, pattern recognition could capture patient-specific seizure precursors. Further investigation on additional datasets should include the seizure prediction horizon. PMID: 19837629 [PubMed - as supplied by publisher] (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - October 15, 2009 Category: Neurology Authors: Mirowski P, Madhavan D, Lecun Y, Kuzniecky R Tags: Clin Neurophysiol Source Type: journals

Clinical ERPs: From consternation toward elucidation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19836994 [PubMed - as supplied by publisher] (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - October 14, 2009 Category: Neurology Authors: Coburn KL Tags: Clin Neurophysiol Source Type: journals

Corticospinal activation confounds cerebellar effects of posterior fossa stimuli.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
CONCLUSIONS: CST collaterals are known to contact cortical inhibitory interneurones; antidromic CST activation could therefore contribute to the observed suppression of cortical MEPs. SIGNIFICANCE: PF stimulation probably activates multiple pathways; even at low intensities it should not be regarded as a selective assessment of cerebellar function unless stringent controls can confirm the absence of confounding activity in other pathways. PMID: 19836995 [PubMed - as supplied by publisher] (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - October 14, 2009 Category: Neurology Authors: Fisher KM, Lai HM, Baker MR, Baker SN Tags: Clin Neurophysiol Source Type: journals

Computerized epileptiform transient detection in the scalp electroencephalogram: Obstacles to progress and the example of computerized ECG interpretation.Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Computerized detection of epileptiform transients (ETs), also called spikes and sharp waves, in the electroencephalogram (EEG) has been a research goal for the last 40years. A reliable method for detecting ETs could improve efficiency in reviewing long EEG recordings and assist physicians in interpreting routine EEGs. Computer algorithms developed so far for detecting ETs are not as reliable as human expert interpreters, mostly due to the large number of false positive detections. Typical methods for ET detection include measuring waveform morphology, detecting signal non-stationarity, and power spectrum analysis. Some...
Source: Clinical Neurophysiology - October 13, 2009 Category: Neurology Authors: Halford JJ Tags: Clin Neurophysiol Source Type: journals

Spike-wave seizures: Cortical or thalamic?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
PMID: 19833551 [PubMed - as supplied by publisher] (Source: Clinical Neurophysiology)
Source: Clinical Neurophysiology - October 12, 2009 Category: Neurology Authors: Amzica F Tags: Clin Neurophysiol Source Type: journals