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Meetings' NoticesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical Oncology)
Source: Clinical Oncology - November 9, 2009 Category: Radiology Tags: Meetings' Notices Source Type: journals

Closer Monitoring of Patients Treated with Sunitinib for Advanced Renal CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aim/introduction: Sunitinib has been approved by NICE and is recommended as a first-line treatment option for people with advanced and/or metastatic renal cell carcinoma. This recommendation was based on the findings of Motzer et al. In addition to demonstrating improved survival for sunitinib as compared with interferon-alpha, this study also revealed moderate side-effects and the requirement for dose modification. Although treatment is delivered over 6 weekly cycles, we postulate more frequent monitoring is required to maintain patients on therapy. The aim of this study was to evaluate the toxicities and outcomes of trea...
Source: Clinical Oncology - November 9, 2009 Category: Radiology Authors: N. Thanvi, C. Ferguson, M. Khan, P. Kirkbride, O. Din Tags: Abstracts Source Type: journals

Long Term Follow-up of Patients Receiving High Dose Rate (HDR) Brachytherapy Boost in Combination with External Beam Radiotherapy Treatment (EBRT) for High Risk Prostate Cancer: Relapse Rate and ToxicityEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aim/introduction: Prostate cancer is the most commonly diagnosed male cancer in the UK; one third of all new cases present with locally advanced disease. At UCLH, high risk patients deemed to benefit from dose escalation have been treated with combined EBRT and HDR brachytherapy boost since 2000. We revisited 32 of these patients to assess late bowel and bladder toxicity, survival, biochemical relapse and metastatic disease rates. (Source: Clinical Oncology)
Source: Clinical Oncology - November 9, 2009 Category: Radiology Authors: A. Swampillai, R. Lewis, H. Payne Tags: Abstracts Source Type: journals

Metronomic Cyclophosphamide and Dexamethasone is Active in Docetaxel, Castration Refractory, Prostate CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aim/introduction: Previous studies have shown the activity of metronomic cyclophosphamide-based chemotherapy regimens in the treatment of docetaxel naive, castration refractory prostate cancer [1]. (Source: Clinical Oncology)
Source: Clinical Oncology - November 9, 2009 Category: Radiology Authors: D. Peel, S. Sundar Tags: Abstracts Source Type: journals

Hormone Therapy for Prostate Cancer Induces the Metabolic Syndrome: is it Preventable?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aim/introduction: The association between androgen deprivation therapy (ADT) for prostate cancer and metabolic syndrome has been reported, with insulin resistance as the key to its development. This is the first study to investigate the effect of metformin and lifestyle changes on the development of ADT-related metabolic syndrome. (Source: Clinical Oncology)
Source: Clinical Oncology - November 9, 2009 Category: Radiology Authors: J. Nobes, S. Langley, J. Money-Kyrle, R. Laing Tags: Abstracts Source Type: journals

Single-agent Carboplatin AUC10 for Metastatic Seminoma with IGCCCG Good Prognosis Disease; a Feasibility Study of the Orchid Clinical Trials GroupEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aim/introduction: To assess the safety, efficacy and toxicity of higher dose single-agent carboplatin chemotherapy (AUC10) in the treatment of metastatic seminoma, in order to maintain/improve efficacy whilst achieving minimal toxicity. (Source: Clinical Oncology)
Source: Clinical Oncology - November 9, 2009 Category: Radiology Authors: A. Matakidou, K. Mutsvangwa, W. Ansell, T. Powles, T. Oliver, J. Shamash Tags: Abstracts Source Type: journals

Dose Escalated Radiotherapy in the Treatment of Locally Advanced Prostate Cancer using High Dose Rate Brachytherapy in Combination with Whole Pelvic Radiotherapy: a Single Centre ExperienceEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present the outcome of dose escalation treatment using high dose rate brachytherapy in combination with whole pelvic external beam radiotherapy in the treatment of locally advanced prostate cancer, in our centre. (Source: Clinical Oncology)
Source: Clinical Oncology - November 9, 2009 Category: Radiology Authors: D. Muthu Kumar, A. Arora, L. Speed, R. Vijayuan, P. Hoskin Tags: Abstracts Source Type: journals

The Christie Experience of Neoadjuvant Chemotherapy for Invasive Bladder Cancer. Tolerance, Short Term Response and Time to Definitive TreatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aim/introduction: Neoadjuvant chemotherapy in muscle-invasive bladder cancer has demonstrated a 5% improvement in absolute overall survival (OS) at 5 years. This retrospective study addressed the tolerance and response to this approach. (Source: Clinical Oncology)
Source: Clinical Oncology - November 9, 2009 Category: Radiology Authors: B. Jyoti, C. Chan, D. Corgie, A. Choudhury, J. Wylie Tags: Abstracts Source Type: journals

Can Large Prostates be Treated Effectively with Real Time Prostate Brachytherapy with an Acceptable Toxicity Profile?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a 5 year experience of real time brachytherapy in large (LP) and standard prostates (SP). (Source: Clinical Oncology)
Source: Clinical Oncology - November 9, 2009 Category: Radiology Authors: N. Dallas, A. Doggart, P. Rogers, P. Malone, A. Jones Tags: Abstracts Source Type: journals

Epirubicin, Carboplatin and 5-Fluorouracil (E-Carbo-F) after Docetaxel and Vice Versa in Castration Resistant Prostate CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aim/introduction: This single institution study compared epirubicin/carboplatin/5-fluorouracil (E-Carbo-F) as second-line chemotherapy after docetaxel with docetaxel after E-Carbo-F in castration resistant prostate cancer (CRPC). (Source: Clinical Oncology)
Source: Clinical Oncology - November 9, 2009 Category: Radiology Authors: P. Bezecny, S. Harland Tags: Abstracts Source Type: journals

Acute Toxicity after Single Fraction High Dose Rate Brachytherapy with External Beam Radiotherapy in Intermediate and High Risk Prostate CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report our experience of a single HDR fraction. (Source: Clinical Oncology)
Source: Clinical Oncology - November 9, 2009 Category: Radiology Authors: N. Alam, C. Taylor, P. Mandall, L. James, J. Logue, J. Wylie Tags: Abstracts Source Type: journals

Advances in Radiotherapy Conference Head and Neck and Breast CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
9–10 October 2009 Northern Centre for Cancer Care, Freeman Hospital, Newcastle upon Tyne, UK (Source: Clinical Oncology)
Source: Clinical Oncology - November 9, 2009 Category: Radiology Tags: Abstracts Source Type: journals

The Effect on Pelvic Lymph Node Dose after Reducing the Internal Margin of the Planning Target Volume for Bladder CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
In a recent paper by Mangar et al. examining the interfractional changes in volume and position during bladder radiotherapy using an empty bladder protocol, it was suggested that reducing the internal margin of the planning target volume (PTV) to 1cm was feasible. An editorial by Lalondrelle and Huddart also discussed the use of smaller margins around the bladder to reduce toxicity. (Source: Clinical Oncology)
Source: Clinical Oncology - November 9, 2009 Category: Radiology Authors: A.H. Thomson, A. Watterson, A. Liddicoat Tags: Letters Source Type: journals

Optimising the Timing of Surgery using Serial Magnetic Resonance Imaging after Long-Course Chemoradiotherapy for Locally Advanced Rectal CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sir — We were interested to read the paper by Dhadda et al. on optimising the timing of surgical resection of rectal cancer after long-course radiotherapy (LCRT) by calculating ‘volume-halving times’. In their series of 106 patients, they noted that the median tumour volume was 54cm3 and the median tumour-halving time was 14 days (i.e. 10 volume-halving times, 140 days), such that an interval of 20 weeks after the start of radiotherapy would be required to achieve tumour regression to (Source: Clinical Oncology)
Source: Clinical Oncology - November 9, 2009 Category: Radiology Authors: B. Sizer, T. Arulampalam, N. Lacey, R.W. Motson Tags: Letters Source Type: journals

Development of Brain Metastases in the Absence of Extracranial Metastases during Adjuvant Treatment for Colon CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Brain metastases from colorectal cancer are uncommon, with various studies reporting their development in between 0.3 and 9% of patients . However, over the last 20 years the development of more effective systemic therapies for colorectal cancer, both chemotherapies and biological agents, has altered the natural history of the disease, and the incidence of secondary brain metastases is increasing . The prognosis of patients with colorectal cancer brain metastases is poor, with a median survival of 5.1 months . (Source: Clinical Oncology)
Source: Clinical Oncology - November 9, 2009 Category: Radiology Authors: L.M. Gossage, V. Potter Tags: Letters Source Type: journals

Incidence and Correlates of Radiation Dermatitis in Children and Adolescents Receiving Radiation Therapy for the Treatment of Paediatric SarcomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Aims: To investigate the relationship between the maximum grade of skin toxicity, radiation dose and clinical variables in children receiving treatment for sarcomas involving the bone and soft tissue.Materials and methods: Between January 2003 and July 2006, 82 patients with musculoskeletal tumours on an Institutional Review Board (IRB)-approved prospective study at St. Jude Children's Research Hospital received three-dimensional conformal or intensity-modulated radiation therapy for local tumour control. Radiation dermatitis was graded according to the National Cancer Institute's Common Toxicity Criteria version...
Source: Clinical Oncology - November 9, 2009 Category: Radiology Authors: M.J. Krasin, K.A. Hoth, C. Hua, J.M. Gray, S. Wu, X. Xiong Tags: Original Articles Source Type: journals

Treatment of Aggressive Fibromatosis: the Experience of a Single InstitutionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Aggressive fibromatosis is effectively treated with surgery and postoperative radiotherapy. Patients first presenting with tumour recurrence may still have local tumour control comparable with newly diagnosed patients. (Source: Clinical Oncology)
Source: Clinical Oncology - November 9, 2009 Category: Radiology Authors: M. El-Haddad, M. El-Sebaie, R. Ahmad, E. Khalil, M. Shahin, R. Pant, M. Memon, A. Al-Hebshi, Y. Khafaga, M. Al-Shabanah, A. Allam Tags: Original Articles Source Type: journals

The Prevalence of Human Papillomavirus Type 58 in Chinese Patients with Cervical Carcinoma and its Influence on SurvivalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: No effect was seen of either treatment protocols or HPV type on survival, except for a slightly high survival in HPV 58 single-infected patients, which was statistically non-significant. (Source: Clinical Oncology)
Source: Clinical Oncology - November 9, 2009 Category: Radiology Authors: Walayat Shah, Chen Hongwei, Zheng Jin, Dong Lifang, Yu Jun, Wang Yili Tags: Original Article Source Type: journals

Rectal Filling at Planning Does Not Predict Stability of the Prostate Gland during a Course of Radical Radiotherapy if Patients with Large Rectal Filling are Re-imagedEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: No statistically significant relationship between rectal distension on planning computed tomography and the intra- and interfraction stability of the prostate gland was identified if patients with a large rectal volume were rescanned for planning. (Source: Clinical Oncology)
Source: Clinical Oncology - November 9, 2009 Category: Radiology Authors: A.L. Stillie, T. Kron, C. Fox, A. Herschtal, A. Haworth, A. Thompson, R. Owen, K.H. Tai, G. Duchesne, F. Foroudi Tags: Original Article Source Type: journals

A Population-based Study of Spinal Metastatic Disease in South-East NorwayEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Population-based incidences of SMD requiring local treatment have been reported for the first time. The prevalence of MSCC at the time of cancer diagnosis was higher than previously reported. A more precise definition of MSCC and more population-based studies are needed to reduce selection bias when comparing different studies. (Source: Clinical Oncology)
Source: Clinical Oncology - November 9, 2009 Category: Radiology Authors: O. Zaikova, K.-E. Giercksky, S.D. Fosså, S. Kvaløy, T.B. Johannesen, S. Skjeldal Tags: Original Articles Source Type: journals

Pattern of Relapse after Fractionated External Beam Radiotherapy for Meningioma: Experience from Addenbrooke's HospitalEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our cohort of patients had an overall local control and survival similar to those documented from other departments. Grade was an important prognostic factor. Patients treated with >50Gy had worse local control outcomes, probably due to selection bias. Dose escalation may still be appropriate for high-risk disease, and may be more effective with more conformal techniques, such as intensity-modulated radiotherapy. (Source: Clinical Oncology)
Source: Clinical Oncology - November 9, 2009 Category: Radiology Authors: V. Estall, S.J. Treece, R. Jena, S.J. Jefferies, K.E. Burton, R.A. Parker, N.G. Burnet Tags: Original Articles Source Type: journals

Radiation-induced Xerostomia: Pathophysiology, Prevention and TreatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We present a review of published studies describing and reporting xerostomia and discuss advances made in the prevention and treatment of this common toxicity. (Source: Clinical Oncology)
Source: Clinical Oncology - November 9, 2009 Category: Radiology Authors: S.A. Bhide, A.B. Miah, K.J. Harrington, K.L. Newbold, C.M. Nutting Tags: Overview Source Type: journals

Meetings' NoticesEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
(Source: Clinical Oncology)
Source: Clinical Oncology - October 5, 2009 Category: Radiology Tags: Meetings' Notices Source Type: journals

Variation in Early Breast Cancer Systemic Adjuvant Therapy Practice among UK Oncologists with Potential Impact on Patient Benefit and the Financial Burden: National Postal Questionnaire SurveyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sir — Anonymous questionnaire survey forms were posted to 201 breast oncologists in 38 cancer networks across the UK in July 2008. Ninety-six oncologists (48%) from 35 networks (92%) responded (1–12 oncologists/network: median=2; 1–4 oncologists/hospital: median=1). For a 55-year-old fit and well woman, uses of anthracycline (no taxane) and taxane chemotherapy were 95% vs 3% for pN0, 50% vs 50% for pN1 and 9% vs 91% for pN2-3. Nine oncologists from seven networks used only anthracycline chemotherapy (no taxane) for any nodal status. Some oncologists also looked at tumour grade and oestrogen receptor status to make th...
Source: Clinical Oncology - October 5, 2009 Category: Radiology Authors: M.M.M. Moe Tags: Letters Source Type: journals

Benchmark 30-day Mortality Rate NeededEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sir — The recent UK National Confidential Enquiry into Patient Outcome and Death (NCEPOD) report, For better, for worse, examined the care of patients who died within 30 days of receiving systemic anticancer treatment (SACT) . This has stimulated debate around concepts such as an ‘acute oncology service’ designed to address key findings in the report. (Source: Clinical Oncology)
Source: Clinical Oncology - October 5, 2009 Category: Radiology Authors: R. Banner Tags: Letters Source Type: journals

Tumour Flare during Interruption of Temsirolimus Treatment for Metastatic Renal Cell CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sir — Temsirolimus has been proven to improve overall survival in poor prognosis patients with metastatic renal cell cancer compared with interferon alpha or interferon alpha plus temsirolimus and prolonged responses to treatment have previously been documented . We would like to report the first case of tumour flare during interruption of treatment of metastatic renal cell carcinoma with temsirolimus. (Source: Clinical Oncology)
Source: Clinical Oncology - October 5, 2009 Category: Radiology Authors: C. Paterson, R.J. Jones Tags: Letters Source Type: journals

Response on Behalf of the UK Stereotactic Body Radiotherapy Consortium to Brock et al. Clin Oncol (R Coll Radiol) 2008;20(9):666–676Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sir — We congratulate Brock et al. on their timely review of hypofractionated small volume radiotherapy for early-stage non-small cell lung cancer (NSCLC). This letter represents the view of the UK Stereotactic Body Radiotherapy (SBRT) Consortium, which was established in January 2006, and currently includes 21 centres. The consortium has been reviewing published studies on lung SBRT, assessing the technologies available in member departments and working towards developing a set of voluntary recommendations intended to facilitate the controlled introduction of SBRT for early-stage, peripheral NSCLC into the clinic. (Sou...
Source: Clinical Oncology - October 5, 2009 Category: Radiology Authors: K.N. Franks, P. Jain, M. Dahele, C. Peedell, M.Q. Hatton, C. Faivre-Finn Tags: Letters Source Type: journals

Thirty-day Mortality for Patients with Genitourinary Malignancies Being Treated with ChemotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The National Confidential Enquiry into Patient Outcome and Death (NCEPOD) 2008 report recognised the importance of 30-day mortality for patients receiving systemic anticancer therapy (SACT) . Overall, 2.2% of patients receiving SACT died within 30 days, although site-specific data were not available. It was advised that all deaths within this timeframe should be considered at mortality/morbidity or clinical governance meetings. After this recommendation, the uro-oncology team at The Christie presented their SACT 30-day mortality data for the period of January–December 2008. During this time, 230 patients with genitourina...
Source: Clinical Oncology - October 5, 2009 Category: Radiology Authors: A. Bradshaw, J. Lyons, J.P. Logue, A. Choudhury Tags: Letters Source Type: journals

Prognosis of Patients with Triple-negative Breast Cancer and Brain MetastasisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sir — Brain metastasis from primary breast cancer is a frequent clinical dilemma with few effective therapeutic options. We undertook a study to characterise the receptor profile of breast cancer patients with brain metastasis compared with an unselected control population, and to assess the outcome of brain metastasis patients with triple-negative breast cancers (TNBC) compared with the other subgroups. (Source: Clinical Oncology)
Source: Clinical Oncology - October 5, 2009 Category: Radiology Authors: R. Venkitaraman, T. Joseph, A. Dhadda, A. Chaturvedi, S. Upadhyay Tags: Letters Source Type: journals

A Retrospective Study of Concurrent Chemoradiation using Mitomycin, Vinblastine and Cisplatin Chemotherapy for Non-small Cell Lung CancerEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
The paper by Pemberton et al. is an interesting non-randomised comparison of continuous hyperfractionated accelerated radiotherapy (CHART) and 55Gy in 20 fractions. The original CHART trial showed superiority for CHART, but we were never certain whether this was a reflection of the low dose (60Gy in 30 fractions) in the standard arm. The evidence for 60Gy in 30 fractions being the gold standard was tenuous . (Source: Clinical Oncology)
Source: Clinical Oncology - October 5, 2009 Category: Radiology Authors: G. Newman Tags: Letters Source Type: journals

An Assessment of Action Levels in Imaging Strategies in Head and Neck Cancer using TomoTherapy. Are Our Margins Adequate in the Absence of Image Guidance?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Reducing the action level at which the systematic error is corrected improves the probability of treatment delivery accuracy. Using the NAL correction protocol reduces the number of fractions that have set-up displacements outside a 5mm CTV–PTV margin. Although a 5mm margin is probably sufficient for standard HNC radiotherapy, change to a 3mm margin is not favoured at our centre without access to daily image-guided radiotherapy. (Source: Clinical Oncology)
Source: Clinical Oncology - October 5, 2009 Category: Radiology Authors: F. Houghton, R.J. Benson, G.S.J. Tudor, J. Fairfoul, J. Gemmill, J.C. Dean, D.S. Routsis, S.J. Jefferies, N.G. Burnet Tags: Original Articles Source Type: journals

Respiratory Movement of Upper Abdominal Organs and its Effect on Radiotherapy Planning in Pancreatic Cancer1Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The present study shows a simple way of incorporating organ motion into the planning process and can be adopted by any centre without major strain on healthcare resources. The use of individualised margins reduced PTV volume and the dose to OARs. This may offer an opportunity for dose escalation to try and further improve local control. (Source: Clinical Oncology)
Source: Clinical Oncology - October 5, 2009 Category: Radiology Authors: S. Gwynne, L. Wills, G. Joseph, G. John, J. Staffurth, C. Hurt, S. Mukherjee Tags: Original Articles Source Type: journals

Integral Dose in Three-dimensional Conformal Radiotherapy, Intensity-modulated Radiotherapy and Helical TomotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Aims: To evaluate the integral dose to organs at risk (OARs), normal tissue and the whole body in three-dimensional conformal radiotherapy (3DCRT), intensity-modulated radiotherapy (IMRT) and helical tomotherapy for whole pelvic radiotherapy (WPRT) in postoperative endometrial cancer patients.Materials and methods: We selected 10 patients with endometrial cancer undergoing postoperative WPRT. Plans of 6MV-3DCRT, 18MV-3DCRT, 6MV-IMRT, 18MV-IMRT and helical tomotherapy were developed for each patient. The integral doses to OARs, normal tissue and the whole body were compared.Results: Compared with 3DCRT, both IMRT ...
Source: Clinical Oncology - October 5, 2009 Category: Radiology Authors: R. Yang, S. Xu, W. Jiang, C. Xie, J. Wang Tags: Original Articles Source Type: journals

Pathology of Soft Tissue SarcomasEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Sarcomas are a rare, complex group of childhood and adult neoplasms with differentiation towards mesenchymal tissue, which may arise almost anywhere in the body. Although pathologically diverse, they frequently exhibit similar clinical presentations and radiological features. Correct histopathological diagnosis is therefore crucial, but there is overlap between histological patterns of malignant tumours, between benign and malignant lesions, and with non-mesenchymal tumours. Immunohistochemistry and molecular genetic techniques, the latter to detect tumour-specific alterations, add significantly to histological i...
Source: Clinical Oncology - October 5, 2009 Category: Radiology Authors: K. Thway Tags: Overview Source Type: journals

Estimated Dose to the Rectum and Colon in Prostate Cancer Patients Treated with Exclusive Radiation Therapy Presenting a Secondary Colorectal MalignancyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: These data suggest that the administered dose after EBRT for prostate cancer to the colon, excluding the rectum, may be below the Gy unit in sCRC patients. (Source: Clinical Oncology)
Source: Clinical Oncology - October 5, 2009 Category: Radiology Authors: D.C. Weber, H. Wang, C. Bouchardy, A. Rosset, E. Rapiti, F. Schmidlin, M. Rouzaud, R. Miralbell Tags: Original Article Source Type: journals

Acute Toxicities Experienced during Simultaneous Integrated Boost Intensity-modulated Radiotherapy in Head and Neck Cancers — Experience from a North Indian Regional Cancer CentreEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: SIB IMRT as used in this study was feasible, although associated with increased rates of mucosal and dermal toxicity. (Source: Clinical Oncology)
Source: Clinical Oncology - October 5, 2009 Category: Radiology Authors: S. Chakraborty, S. Ghoshal, V. Patil, A. Oinam, S. Suresh Tags: Original Article Source Type: journals

Quality of Life after Accelerated Partial Breast Irradiation in Early Breast Cancer: Matched Pair Analysis with Protracted Whole Breast RadiotherapyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Favourable long-term results of APBI in terms of superior body image perception and lesser financial difficulties compared with WBRT need to be confirmed in larger prospective studies investigating the effect of APBI on quality of life and health economics in different ethnic groups and health care set-ups. (Source: Clinical Oncology)
Source: Clinical Oncology - October 5, 2009 Category: Radiology Authors: T. Wadasadawala, A. Budrukkar, S. Chopra, R. Badwe, R. Hawaldar, V. Parmar, R. Jalali, R. Sarin Tags: Original Article Source Type: journals

Combining Systemic Bisphosphonates with Palliative External Beam Radiotherapy or Bone-Targeted Radionuclide Therapy: Interactions and EffectivenessEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bisphosphonates, external beam radiotherapy and bone-seeking radiopharmaceuticals (BSRs) have an established role for the management of metastatic bone disease. Radiotherapy achieves significant pain relief and a decrease in local skeletal complication rates . The exact mechanism by which pain relief is achieved is unknown. It has been suggested that a high level of tumour and inflammatory cell kill and the subsequent decrease in osteoclastic activity play a role . BSRs bring about a similar effect in areas of increased uptake by local radiation emission. These mechanisms may be an important link for the possible synergist...
Source: Clinical Oncology - October 5, 2009 Category: Radiology Authors: V. Vassiliou, Ø. Bruland, N. Janjan, S. Lutz, D. Kardamakis, P. Hoskin Tags: Editorials Source Type: journals

The Treatment of Bone Metastasis with Highly Conformal Radiation Therapy: A Brave New World or a Costly Mistake?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conventional radiotherapy is an integral part of treatment for bone metastasis as primary treatment for symptomatic sites or as an adjuvant treatment after surgical decompression of spinal cord compression or therapeutic or prophylactic internal fixation of the involved bone . (Source: Clinical Oncology)
Source: Clinical Oncology - October 5, 2009 Category: Radiology Authors: S.S. Lo, A. Sahgal, W.F. Hartsell, S.T. Lutz, D. Kardamakis, Y. van der Linden, P.J. Hoskin Tags: Editorials Source Type: journals

Update on Palliative Radiotherapy Endpoints for Bone Metastasis TrialsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A disproportionate percentage of healthcare funds are spent on patients in the final days of life . The aging of the populations of several countries will require the distribution of healthcare resources over a greater number of patients, necessitating cost vs. benefit analyses of end of life interventions. The comparison of treatment outcomes requires the evaluation of both objective and subjective measures, as well as their effects on quality of life. The value of the results from prospective trials may therefore only be maximised by homogeneity of data collection and the reporting of results. (Source: Clinical Oncology)
Source: Clinical Oncology - October 5, 2009 Category: Radiology Authors: S. Lutz, P. Hoskin, E. Chow Tags: Editorials Source Type: journals

International Variations in Radiotherapy Fractionation for Bone Metastases: Geographic Borders Define Practice Patterns?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Abstract: Although it may be argued that single fraction (SF) radiotherapy (RT) should be regarded as the standard palliative treatment for pain due to uncomplicated bone metastases, its widespread clinical use is still underexploited. In this chapter, the authors discuss a number of surveys investigating doctors and patients' preferences for palliative RT schedules, discuss the possible reasons for this phenomenon, and suggest potential strategies to increase the use of SF. (Source: Clinical Oncology)
Source: Clinical Oncology - October 5, 2009 Category: Radiology Authors: Y. van der Linden, D. Roos, S. Lutz, A. Fairchild Tags: Editorials Source Type: journals

Single Fraction Radiotherapy for Bone Metastases: Clinically Effective, Time Efficient, Cost Conscious and Still Underutilized in the United States?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Although the majority of patients with newly diagnosed cancer will be cured, a substantial number will develop metastatic disease. In most of these patients, treatment is palliative in intent. The goal of palliative treatment is to return the patient to an optimum quality of life as soon as possible, recognizing that protracted treatments may occupy much of the patients' remaining life . For painful bone metastases, the ideal treatment would be clinically effective, minimally toxic, time efficient and cost conscious. Multiple randomised trials have shown that there is such a treatment: single fraction palliative radiothera...
Source: Clinical Oncology - October 5, 2009 Category: Radiology Authors: W.F. Hartsell, A.A. Konski, S.S. Lo, J.A. Hayman Tags: Editorials Source Type: journals

Background, Rationale and Goals for the 2010 International Consensus Conference Bone Metastasis Treatment WorkshopEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
External beam radiotherapy continues to be a mainstay for the successful treatment of patients with symptoms caused by cancer. The delivery of palliative radiotherapy is effective, time-efficient, relatively inexpensive and associated with a low risk of side-effects . However, the management of patients with painful bone metastases is complex and requires the integration of several medical disciplines. That complexity, coupled with the lack of palliative care guidelines, helped lead to the formation of the First International Consensus Workshop on radiation in the treatment of metastatic and locally advanced cancer in 1990...
Source: Clinical Oncology - October 5, 2009 Category: Radiology Authors: S.T. Lutz, A. Fairchild, E. Chow, P. Hoskin Tags: Editorials Source Type: journals

British Association of Head and Neck Oncologists Annual Scientific MeetingEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
24 April 2009 (Royal College of Physicians, London) (Source: Clinical Oncology)
Source: Clinical Oncology - September 7, 2009 Category: Radiology Tags: Abstracts Source Type: journals

Proposed Ethics and Law Component of the Clinical Oncology CurriculumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sir — I am interested to read the letter and proposal by Guglani and Benstead and would be very much in favour of taking forward its incorporation into the curriculum. There are many examples of communication skills components to higher medical training curricula, some of which incorporate ethical and legal issues. Closely related to oncology is palliative medicine, in which communication skills to be obtained are outlined as a subheading under psychosocial care, and ethical issues to be understood and practiced are listed in their own paragraph later . There are also many different formats of medical curricula, not all...
Source: Clinical Oncology - September 7, 2009 Category: Radiology Authors: R.L. Eakin Tags: Letters Source Type: journals

Oral Bisphosphonates, Concurrent Thoracic Radiotherapy and OesophagitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 67-year-old woman had a left mastectomy for breast carcinoma in 1996. Ten years later she developed chest wall recurrence, which was excised and treated with postoperative radiotherapy without complications. (Source: Clinical Oncology)
Source: Clinical Oncology - September 7, 2009 Category: Radiology Authors: C. Lee, B. Magee Tags: Letters Source Type: journals

Does HER-2 Over-expressing Breast Cancer have a Predilection to Metastasise to the Brain?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sir — After several reports of an increased rate of central nervous system (CNS) relapse in patients with metastatic HER-2-positive breast tumours treated with trastuzumab , we retrospectively examined a series of breast cancer patients with brain metastases for the presence of HER-2 and oestrogen receptors. (Source: Clinical Oncology)
Source: Clinical Oncology - September 7, 2009 Category: Radiology Authors: C. Paterson, A. Mcintyre, P.A. Canney Tags: Letters Source Type: journals

Trastuzumab-induced Radiation Recall Dermatitis — First Reported CaseEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sir — We would like to report the first case to our knowledge of radiation recall dermatitis (RRD) triggered by trastuzumab (Herceptin®). A 71-year-old woman with previous left mastectomy for ductal carcinoma in situ presented with distortion of her right breast in February 2008. Ultrasound-guided core biopsy confirmed invasive ductal carcinoma. She underwent right-sided mastectomy and axillary nodal dissection. Histopathology confirmed multifocal invasive breast cancer. Two tumours were identified: a grade III, 35mm, oestrogen receptor-positive, progesterone receptor-negative, Her2-positive invasive ductal cancer and a...
Source: Clinical Oncology - September 7, 2009 Category: Radiology Authors: R.K. Shrimali, N.J. McPhail, P.D. Correa, J. Fraser, M. Rizwanullah Tags: Letters Source Type: journals

A Cross-over Response to Sequential Use of Sunitinib after Sorafenib in a Patient with Metastatic Renal Cell CarcinomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
A 62-year-old man underwent a right nephrectomy for clear cell carcinoma of the kidney, but relapsed within 1 year with liver metastases. He was initially treated with sorafenib 400mg orally twice a day; a baseline scan revealed a 32mm index liver metastasis (A). Repeated scanning 6 months later showed progression of the liver metastasis increasing to 54mm (B). Sunitinib, 50mg orally once a day, using a regimen of 4 weeks on and 2 weeks off treatment, was substituted. Three months later, repeat scanning showed a response (C), with a reduction in the liver metastasis to 41mm, which is maintained out to 1 year. (Source: Clinical Oncology)
Source: Clinical Oncology - September 7, 2009 Category: Radiology Authors: T.M. Richards, P.N. Plowman, R. Reznek, S.A. Ball Tags: Letters Source Type: journals

A Case of Capecitabine-induced Hyperpigmentation and Radiation Recall PhenomenonEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report an unusual case of skin hyperpigmentation and radiation recall phenomenon after the administration of capecitabine. A 44-year-old patient with a previous history of right mastectomy for an invasive ductal carcinoma underwent neoadjuvant chemotherapy (six cycles of adriamycin and cyclophosphamide), left mastectomy, chest wall and supraclavicular fossa radiotherapy for a T3, oestrogen receptor-positive second primary invasive lobular carcinoma in the left breast. She developed pleural, liver and bone metastasis while still on adjuvant anastrazole about 28 months from the completion of her left chest wall radiother...
Source: Clinical Oncology - September 7, 2009 Category: Radiology Authors: N. Ghosal, V. Misra Tags: Letters Source Type: journals