Clinical OphthalmologyThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader, such as GoogleReader, or to display this data on your own website or blog. Subscribe to this data using MyMedWorm.Subscribe to this data using GoogleReader.Subscribe to this data using Bloglines.Subscribe to this data using MyYahoo.

This page shows you the latest items in this publication.

Topical ophthalmic NSAIDs: a discussion with focus on nepafenac ophthalmic suspensionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bruce I Gaynes1,2, Anne Onyekwuluje11Departments of Ophthalmology and 2Pharmacology, Rush College of Medicine, Chicago, Illinois, USAAbstract: The removal of diclofenac sodium ophthalmic solution as a viable pharmaceutical entity in September 1999 from the US market spurred considerable interest in the general safety and effectiveness of topical ophthalmic NSAIDs for treatment of anterior segment inflammation. In late 1999 the use of topical ocular NSAIDs declined in the US as a result of incidents involving corneal melts and toxicity surrounding use of generic diclofenac. However, since the removal of diclofenac sodium op...
Source: Clinical Ophthalmology - June 8, 2008 Category: Opthalmology Source Type: journals

Topical ophthalmic NSAIDs: a discussion with focus on nepafenac ophthalmic suspensionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bruce I Gaynes1,2, Anne Onyekwuluje11Departments of Ophthalmology and 2Pharmacology, Rush College of Medicine, Chicago, Illinois, USAAbstract: The removal of diclofenac sodium ophthalmic solution as a viable pharmaceutical entity in September 1999 from the US market spurred considerable interest in the general safety and effectiveness of topical ophthalmic NSAIDs for treatment of anterior segment inflammation. In late 1999 the use of topical ocular NSAIDs declined in the US as a result of incidents involving corneal melts and toxicity surrounding use of generic diclofenac. However, since the removal of diclofenac sodium op...
Source: Clinical Ophthalmology - June 6, 2008 Category: Opthalmology Source Type: journals

Acute visual loss and intraocular hemorrhages associated with endoscopic spinal surgeryEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: The present case represents an extremely rare incidence of intraocular hemorrhage following epiduroscopy.Keywords: visual acuity, hemorrhage, intraocular, BCVA
Source: Clinical Ophthalmology - June 5, 2008 Category: Opthalmology Source Type: journals

Optic nerve sheath fenestration in cryptococcal meningitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Tatyana Milman1, Neena Mirani1,2, Roger E Turbin11Ophthalmology Department, Institute of Ophthalmology and Visual Science, 2Pathology Department, University Hospital, New Jersey Medical School, Newark, NJ, USAAbstract: A patient with acquired immunodeficiency syndrome (AIDS) developed crytpococcal meningitis, complicated by papilledema and severe progressive visual loss despite medical therapy. Bilateral optic sheath fenestration resulted in significant improvement in vision and resolution of papilledema. Histopathologic evaluation of the optic nerve sheath demonstrated numerous cryptococci. Optic nerve sheath fenestration...
Source: Clinical Ophthalmology - June 5, 2008 Category: Opthalmology Source Type: journals

The trabecular bypass stent in a pseudophakic glaucoma patient: A 1-year follow-upEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: We are not aware of previous reports of trabecular stent implantation in pseudophakic patients. The trabecular stent had minimal peri-operative morbidity. Identification of the implantation site is challenging and reduction of efficacy over time may occur.Keywords: stent, trabecular bypass, intraocular pressure, glaucoma
Source: Clinical Ophthalmology - June 5, 2008 Category: Opthalmology Source Type: journals

Visual and refractive outcome of one-site phacotrabeculectomy compared with temporal approach phacoemulsificationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: In this study the visual outcome of the phacotrabeculectomy group did not differ significantly from the visual outcome of temporal approach phacoemulsification.Keywords: refractive outcome, phacoemulsifi cation, phacotrabeculectomy, astigmatism
Source: Clinical Ophthalmology - June 5, 2008 Category: Opthalmology Source Type: journals

Fixed combination of topical brimonidine 0.2% and timolol 0.5% for glaucoma and uncontrolled intraocular pressureEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Anne J Lee1, Peter McCluskey1,21Department of Ophthalmology, Liverpool Hospital, Liverpool, NSW, Australia; 2Faculty of Medicine, University of New South Wales, Randwick, NSW, AustraliaAbstract: Lowering IOP is the most readily modifiable risk factor to delay the development and progression of glaucoma (POAG). The fixed combination of brimonidine tartrate 0.2% and timolol maleate 0.5% (FCBT) combines a highly selective α2-adrenergic agonist (brimonidine) with a nonselective β-blocker (timolol). FCBT reduces aqueous production and enhances uveoscleral outflow. Concomitant brimonidine and timolol have additive eff...
Source: Clinical Ophthalmology - May 30, 2008 Category: Opthalmology Source Type: journals

Collagen cross-linking: Strengthening the unstable corneaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Oren Tomkins, Hanna J GarzoziDepartment of Ophthalmology, Bnai Zion Medical Center, Haifa, IsraelAbstract: Corneal ectasia, a weakening of corneal integrity, occurs both due to acquired and congenital conditions such as keratoconus. It is a progressing condition that affects both visual acuity, and corneal stability. Various methods exist for correcting this impairment, however none address the inherit pathology, an increase laxity of the corneal stroma. Collagen crosslinking, a new, minimally invasive method, aims to strengthen the stroma by inducing cross links between neighboring collagen fibers. This method results in ...
Source: Clinical Ophthalmology - May 28, 2008 Category: Opthalmology Source Type: journals

Cost effectiveness of a telephone intervention to promote dilated fundus examination in adults with diabetes mellitusEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Clyde B Schechter1, Charles E Basch2, Arlene Caban3, Elizabeth A Walker41Departments of Family and Social Medicine and Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USA; 2Department of Health Behavior Studies, Teachers College, Columbia University, New York, NY, USA; 3Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA; 4Departments of Medicine and Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York, USAAbstract: In a clinical trial, we have previously shown that a telephone intervention can significantly increase parti...
Source: Clinical Ophthalmology - May 28, 2008 Category: Opthalmology Source Type: journals

Clinical experience with pegaptanib sodiumEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Chiara Rosina, Ferdinando Bottoni, Giovanni StaurenghiLuigi Sacco Hospital, University of Milano, ItalyAbstract: Pegaptanib sodium (Macugen®) blocks the extracellular vascular endothelial growth factor (VEGF) isoform VEGF165, whose elevated levels are associated with the development of choroidal neovascularization (CNV). This selective inhibition prevents binding to the VEGF receptors and the development of the increased vascular permeability and the CNV associated with neovascular age-related degeneration (AMD). The VEGF Inhibition Study In Ocular Neovascularization (VISION) demonstrated that pegaptanib sodium confers...
Source: Clinical Ophthalmology - May 26, 2008 Category: Opthalmology Source Type: journals

Analysis of sFas IL-6 levels in thyroid-associated ophthalmopathy: Pre- or poststeroid pulse treatmentEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Serum level of sFas is an accurate index of the outcome of steroid pulse treatment in thyroid-associated ophthalmopathy and may become a useful index to gauge the status of convalescence.Keywords: sFas, IL-6, ELISA, thyroid associated ophthalmopathy, steroid pulse treatment
Source: Clinical Ophthalmology - May 22, 2008 Category: Opthalmology Source Type: journals

A study of the safety and efficacy of travoprost 0.004%/timolol 0.5% ophthalmic solution compared to latanoprost 0.005% and timolol 0.5% dosed concomitantly in patients with open-angle glaucoma or ocular hypertensionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Travoprost 0.004%/timolol 0.5% administered once daily and concomitant administration of timolol 0.5% and latanoprost 0.005% produce similar maintenance of IOP-lowering effect in patients who were previously well controlled on concomitant administration of latanoprost and timolol. Patients who are well controlled on latanoprost and timolol concomitant therapy can be switched to once-daily therapy with travoprost 0.004%/timolol 0.5% with no expected compromise in the safety and efficacy of their treatment.Keywords: travoprost, timolol, glaucoma, intraocular pressure, fixed combination
Source: Clinical Ophthalmology - May 22, 2008 Category: Opthalmology Source Type: journals

Pegaptanib sodium treatment in neovascular age-related macular degeneration: clinical experience in GermanyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: ITV therapy with pegaptanib sodium for occult and minimally classic CNV secondary to neovascular AMD offered good efficacy with a favorable adverse events profile. The majority of patients showed stabilization in all assessed parameters. In clinical practice, careful consideration should be given to the use of nonselective VEGF inhibition in patients with a high cardiovascular risk profile or in those with a history of thromboembolic events.Keywords: Intravitreal (ITV) injection, age-related macular degeneration (AMD), choroidal neovascularization (CNV), anti-VEGF therapy, pegaptanib sodium
Source: Clinical Ophthalmology - May 22, 2008 Category: Opthalmology Source Type: journals

Role of pegaptanib sodium in the treatment of neovascular age-related macular degenerationEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sobha SivaprasadLaser and Retinal Research Unit, King’s College Hospital, UKAbstract: Age-related macular degeneration (AMD) is responsible for more than half the blind registration in the United Kingdom. Retinal manifestations of AMD can be categorized as either atrophic or neovascular. The hallmark of AMD is the development of choroidal neovascularization (CNV). Until recently, there have been few, limited treatment modalities (eg, photodynamic therapy [PDT]) for this condition and the mainstay of treatment has comprised social and lifestyle support. However, increased understanding of the molecular processes at wo...
Source: Clinical Ophthalmology - May 22, 2008 Category: Opthalmology Source Type: journals

Pegaptanib sodium for neovascular age-related macular degeneration: clinical experience in the UKEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sobha Sivaprasad, Nachiketa Acharya, Phil HykinMoorfields Eye Hospital, London, UKAbstract: The pathogenesis of age-related macular degeneration (AMD) is unclear, but it can take either a neovascular/exudative/wet form, characterized by choroidal neovascularization (CNV), or a dry form. No treatments are available for the dry form, but there are a number of pharmacological interventions that inhibit vascular endothelial growth factor (VEGF), which is central to the pathogenesis of CNV and neovascular AMD. Available anti-VEGF agents either target all active VEGF isoforms (eg, ranibizumab), or take a more selective approach ...
Source: Clinical Ophthalmology - May 22, 2008 Category: Opthalmology Source Type: journals

Efficacy and tolerability of a fixed-dose moxifloxacin – dexamethasone formulation for topical prophylaxis in LASIK: a comparative, double-masked clinical trialEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Topical prophylaxis with MFLX/DEX eye drops was well tolerated and is therapeutically equivalent to conventional dosing with moxifloxacin and dexamethasone from individual bottles.Keywords: moxifloxacin, dexamethasone, LASIK, prophylaxis
Source: Clinical Ophthalmology - May 22, 2008 Category: Opthalmology Source Type: journals

Topical ophthalmic NSAIDs: a discussion with focus on nepafenac ophthalmic suspensionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Bruce I Gaynes1,2, Anne Onyekwuluje11Departments of Ophthalmology and 2Pharmacology, Rush College of Medicine, Chicago, Illinois, USAAbstract: The removal of diclofenac sodium ophthalmic solution as a viable pharmaceutical entity in September 1999 from the US market spurred considerable interest in the general safety and effectiveness of topical ophthalmic NSAIDs for treatment of anterior segment inflammation. In the late 1999 the use of topical ocular NSAIDs declined in the US as a result of incidents involving corneal melts and toxicity surrounding use of generic diclofenac. However, since the removal of diclofenac sodiu...
Source: Clinical Ophthalmology - May 22, 2008 Category: Opthalmology Source Type: journals

Relationships between central corneal thickness and optic disc topography in eyes with glaucoma, suspicion of glaucoma, or ocular hypertensionEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Thinner corneas appear to be associated with larger and deeper optic disc cups in the eyes of patients seen in a specialist glaucoma service.Keywords: central corneal thickness, optic disc topography, optic disc compliance, glaucoma
Source: Clinical Ophthalmology - May 22, 2008 Category: Opthalmology Source Type: journals

Use of telemedicine to assist ophthalmologists in developing countries for the diagnosis and management of four categories of ophthalmic pathologyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Discussion: If one considers that the mentors are correct in each case, they offered a different diagnosis in 18% of cases. For treatment, mentors offered an alternate plan in more than a quarter of cases. The basis for considering the mentors being more accurate in diagnosis and treatment planning after viewing pictures and reading history than the partners who actually saw and examined the patients is based on personal experience of the authors. This includes a study done by one of them (EMH) demonstrating that experts when asked to view cases presented via telemedicine agreed nearly 100% on diagnosis and by a like amoun...
Source: Clinical Ophthalmology - May 22, 2008 Category: Opthalmology Source Type: journals

Differential diagnosis of leukocoria and strabismus, first presenting signs of retinoblastomaEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Aubin Balmer, Francis MunierJules Gonin University Eye Hospital, Lausanne, SwitzerlandAbstract: Leukocoria in infants is always a danger signal as retinoblastoma, a malignant retinal tumor, is responsible for half of the cases in this age group. More common signs should also be considered suspicious until proved otherwise, such as strabismus, the second most frequent sign of retinoblastoma. Less frequent manifestations are inflammatory conditions resistant to treatment, hypopyon, orbital cellulitis, hyphema or heterochromia. Other causal pathologies, including persistent hyperplastic primary vitreous (PHPV), Coats’ d...
Source: Clinical Ophthalmology - May 22, 2008 Category: Opthalmology Source Type: journals

Treatment of total exudative retinal detachment due to central retinal vein occlusion by intravitreal bevacizumab in a patient with p-ANCA vasculitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusion: Intravitreal bevacizumab proved to be a useful treatment modality in diffuse exudative retinal detachment due to CRVO.Keywords: bevacizumab, CRVO, exudative retinal detachment, p-ANCA vasculitis
Source: Clinical Ophthalmology - May 22, 2008 Category: Opthalmology Source Type: journals

Neuropathological changes in striate and extrastriate visual cortex in variant Creutzfeldt-Jakob disease (vCJD)Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Richard A ArmstrongVision Sciences, Aston University, Birmingham, UKAbstract: Pathological changes in striate (B17, V1) and extrastriate (B18, V2) visual cortex were studied in variant Creutzfeldt-Jakob disease (vCJD). No differences in densities of vacuoles or surviving neurons were observed in B17 and B18 but densities of glial cell nuclei and deposits of prion protein (PrP) were greater in B18. PrP deposit densities in B17 and B18 were positively correlated. Diffuse deposit density in B17 was negatively correlated with the density of surviving neurons in B18. The vacuoles either exhibited a density peak in laminae II/II...
Source: Clinical Ophthalmology - May 22, 2008 Category: Opthalmology Source Type: journals

Posterior placoid chorioretinitis: An unusual ocular manifestation of syphilisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
We report a case of acute unilateral maculopathy, due to posterior placoid chorioretinitis associated with syphilis, in an immuno-competent patient. Ophthalmoscopy revealed a unilateral yellowish placoid lesion at the macula. Syphilis serology was positive confirming active infection. There were no other systemic signs of syphilis. The patient was treated with intravenous benzylpenicillin 1.2 g every four hours for two weeks. The lesion resolved with treatment and the retinal appearance returned to normal. This case highlights the importance of raising clinical suspicion of syphilis in view of unexplained decreased vision ...
Source: Clinical Ophthalmology - May 22, 2008 Category: Opthalmology Source Type: journals

Thrombophilic screening in retinal artery occlusion patientsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: Our results support the assumption that thrombophilia may contribute to the development of RAO besides vascular damage due to the presence of cardiovascular risk factors. Further studies are needed, however, to justify the possible use of secondary prophylaxis in form of anticoagulant/antiplatelet therapy.Keywords: retinal arterial occlusion, risk factors, thrombophilia
Source: Clinical Ophthalmology - May 22, 2008 Category: Opthalmology Source Type: journals

Dysfunctional regulation of ocular blood flow: A risk factor for glaucoma?Email this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
This article develops the thesis that dysfunctional regulation of ocular blood flow may contribute to glaucomatous optic neuropathy. Evidence suggests that impaired vascular autoregulation renders the optic nerve head susceptible to decreases in ocular perfusion pressure, increases in IOP, and/or increased local metabolic demands. Ischemic damage, which likely contributes to further impairment in autoregulation, results in changes to the optic nerve head consistent with glaucoma. Included in this review are discussions of conditions thought to contribute to vascular regulatory dysfunction in OAG, including atherosclerosis,...
Source: Clinical Ophthalmology - May 22, 2008 Category: Opthalmology Source Type: journals

SUNCT syndrome: The materialization of a headache syndromeEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Ottar SjaastadDepartment of Neurology, St. Olav´s Hospital, 7006 Trondheim University Hospitals, Trondheim, NorwayAbstract: Shortlasting, unilateral, neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) syndrome is a rare headache, described by our group in 1989. This overview presents our early studies of SUNCT pathogenesis. Due to the conspicuous ictal, ocular phenomena, ie, conjunctival injection and tearing, our studies started out with ocular parameters: intraocular pressure and corneal indentation pulse amplitudes, both of which showed clear ictal increments, symptomatic side. Beat-to-b...
Source: Clinical Ophthalmology - May 22, 2008 Category: Opthalmology Source Type: journals

Optic nerve sheath fenestration in cryptococcal meningitisEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Tatyana Milman1, Neena Mirani1,2, Roger E Turbin11Ophthalmology Department, Institute of Ophthalmology and Visual Science, 2Pathology Department, University Hospital, New Jersey Medical School, Newark, NJ, USAAbstract: A patient with acquired immunodeficiency syndrome (AIDS) developed crytpococcal meningitis, complicated by papilledema and severe progressive visual loss despite medical therapy. Bilateral optic sheath fenestration resulted in significant improvement in vision and resolution of papilledema. Histopathologic evaluation of the optic nerve sheath demonstrated numerous crytpococci. Optic nerve sheath fenestration...
Source: Clinical Ophthalmology - May 22, 2008 Category: Opthalmology Source Type: journals

The characteristics of keratomycosis by Beauveria bassiana and its successful treatment with antimycotic agentsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Hiroko Sonoyama1, Kaoru Araki-Sasaki1, Shigeyasu Kazama1, Tsutomu Kawasaki1, Hidenao Ideta1, Atsuko Sunada2, Seishi Asari2, Yoshitsugu Inoue3, Kozaburo Hayashi41Ideta Eye Hospital, Kumamoto, Kumamoto, Japan; 2Department of Laboratory for Clinical Investigation, Osaka University Hospital, Suita, Osaka, Japan; 3Division of Ophthalmology and Visual Science, Department of Medicine of Sensory and Motor Organ, Tottori University, Yonago, Tottori, Japan; 4Immunology and Virology Section Lab, Immunology, NEI, NIH, Bethesda, MD, USAAbstract: Clinical findings and treatment of keratomycosis caused by Beauveria bassiana, an entomopat...
Source: Clinical Ophthalmology - May 22, 2008 Category: Opthalmology Source Type: journals

Autoimmune destruction of pericytes as the cause of diabetic retinopathyEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Duncan D AdamsFaculty of Medicine, University of Otago, Dunedin, New ZealandAbstract: In diabetic retinopathy, collapse of the retinal vasculature is associated with loss of the pericytes. These are contractile cells that together with endothelial cells form the terminal arterioles of the retina. The cause of the loss of pericytes is not known. Recently, it has been discovered that type 1 diabetes is caused by forbidden clones of cytotoxic T lymphocytes, which destroy the insulin-making cells with exquisite specificity. In the light of this, I postulate that an antigenically-related forbidden clone of cytotoxic T lymphocyt...
Source: Clinical Ophthalmology - May 22, 2008 Category: Opthalmology Source Type: journals

Topical treatment options for conjunctival neoplasmsEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Jonathan W Kim, David H AbramsonOphthalmic Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USAAbstract: Topical therapies offer a nonsurgical method for treating conjunctival tumors by delivering high drug concentrations to the ocular surface. Over the past ten years, topical agents have been used by investigators to treat various premalignant and malignant lesions of the conjunctiva, such as primary acquired melanosis with atypia, conjunctival melanoma, squamous intraepithelial neoplasia and squamous cell carcinoma of the conjunctiva, and pagetoid spread of the conjunctiva arising from sebaceous ce...
Source: Clinical Ophthalmology - May 22, 2008 Category: Opthalmology Source Type: journals

Sudden unilateral visual loss after autologous fat injection into the nasolabial foldEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Sang Hyouk Park, Hae Jung Sun, Kyung Seek ChoiDepartment of ophthalmology, Soonchunhyang University College of Medicine, Seoul, KoreaAbstract: A 27-year-old female presented with sudden visual loss of her right eye after receiving an autologous fat injection into the right nasolabial fold. Fundus examination of the right eye showed multiple whitish patchy lesions with macular edema. Fluorescein angiogram showed deterioration of choroidal circulation with patchy choroidal filling and arm-to-retina circulation time and retinal arteriovenous passage time were delayed to 30 seconds and 20 seconds, respectively. There was no re...
Source: Clinical Ophthalmology - May 22, 2008 Category: Opthalmology Source Type: journals

Epstein-Barr virus and acute retinal necrosis in a 5-year-old immunocompetent childEmail this article to a colleague. Save this article to My Clippings. Discuss or comment on this article.
Conclusions: The ARNS is an ocular disease with poor prognosis, which in turns may display better course when determining the etiopathogenic virus and selecting the appropriate and precocious therapy.Keywords: retinal necrosis, epstein-barr virus, antiviral serology, antiviral therapy
Source: Clinical Ophthalmology - May 22, 2008 Category: Opthalmology Source Type: journals