Effects of different primers and colouring solutions on orthodontic bonding: shear bond strength and colour change
ConclusionsIn this study, the bond strength was clinically sufficient in all primer groups. The highest colour change was observed when the tea –coffee solution and Transbond Plus SEP primer were used.Clinical relevanceThis study has identified enamel discoloration and bond strength from different colouring solutions and primer systems used for bonding braces, which can be used to inform clinicians and patients to achieve better treatment results. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - April 25, 2024 Category: Dentistry Source Type: research
Pain symptoms are associated with two-point discrimination threshold in patients with temporomandibular disorders
ConclusionTMJ, zygomatic, and temporal 2-PDs were significantly associated with PT and pain intensity. Age, gender and psychological factors were not associated with orofacial 2-PDs. PT patients exhibited weaker tactile acuity compared to Non-PT patients. Further discussion on the underlying mechanism is needed.Clinical relevanceOrofacial tactile acuity of TMDs patients was associated with their pain symptoms, which researchers should take account into when performing 2-PD tests for TMDs patients. The 2-PD test can be considered as a potential tool along with the current procedures for the differentiations of PT and Non-PT...
Source: Clinical Oral Investigations - April 25, 2024 Category: Dentistry Source Type: research
Randomized controlled clinical trial on the efficacy of a novel antimicrobial chewing gum in reducing plaque and gingivitis in adolescent orthodontic patients
ConclusionBoth chewing gums performed similarly effective in terms of reducing plaque accumulation and gingival inflammation and improving OHRQoL.Clinical relevanceChewing gums without antimicrobial ingredients may be sufficient to decrease plaque accumulation and gingival inflammation. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - April 25, 2024 Category: Dentistry Source Type: research
Oxidative Stress and FOXO-1 Relationship in Stage III Periodontitis
ConclusionsWhile reactive oxygen species increase in periodontal inflammation, low expression of FOXO1, an important transcription factor for antioxidant enzymes, supports that this molecule plays a vital role in tissue destruction, and FOXO1 can be seen as a potential immune modulator.Clinical relevanceThe role of FOXO1 in supporting antioxidant defense may suggest that FOXO1 is a candidate target for periodontitis treatment. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - April 25, 2024 Category: Dentistry Source Type: research
Medial sural artery perforator free flap versus radial forearm free flap in oral cavity reconstruction and donor site morbidity
ConclusionThe MSAPFF is an excellent alternative to the RFFF for repairing oral cavity defects, with additional advantage of a well-hidden scar on the posterior calf, a larger flap thickness, accepted pedicle length and arterial caliber. However, one should consider the harvesting time and surgical skills required in comparison to the RFFF.Clinical relevanceThe study highlights the importance of the MSAPFF as an alternative option for RFFF with less donor site morbidity and high success rate in oral cavity reconstruction and improved patient Quality of life after ablative surgery. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - April 24, 2024 Category: Dentistry Source Type: research
Oral mucosa - an examination map for confocal laser endomicroscopy within the oral cavity: an experimental clinical study
ConclusionA physiological “CLE map” for the entire oral cavity could be created for the first time.Clinical relevanceThis will make it possible to take into account the existing physiological morphological features when differentiating between normal mucosa and oral squamous cell carcinoma in future work. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - April 23, 2024 Category: Dentistry Source Type: research
Prevalence and implications of bilateral and solely contralateral lymph node metastases in oral squamous cell carcinoma
ConclusionsB/SC LNMs are rare in patients with OSCC, especially in those who present with clinico-radiologically negative ipsilateral necks. Higher rates of B/SC metastases occur in case of advanced tumors and those localized at the upper jaw or floor of the mouth. Ipsilateral LNMs significantly elevate the risk of contralateral LNMs, tripling the associated risk.Clinical relevanceThese findings provide valuable insights for surgeons considering contralateral ND or extended adjuvant treatment for OSCC patients. However, the absence of high-level evidence from randomized controlled trials impedes the establishment of a defi...
Source: Clinical Oral Investigations - April 23, 2024 Category: Dentistry Source Type: research
Elimination of E. faecalis with NaOCl versus chlorhexidine gluconate from primary molar root canal systems: an ex vivo model study
ConclusionIn primary teeth, NaOCl and CHG showed similar degrees of bacterial elimination efficacy in terms of E.faecalis.Clinical relevanceWithin the limitations of this study, NaOCl and CHG have the similar ability to perform endodontic irrigation of primary ex vivo teeth regarding the elimination of E.faecalis, but NaOCl penetrates dentin tubules better. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - April 23, 2024 Category: Dentistry Source Type: research
Correction to: Second primary squamous cell carcinoma of the oral cavity – a retrospective cohort study of therapeutic procedures and oncological outcome
(Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - April 23, 2024 Category: Dentistry Source Type: research
Rising incidence of severe maxillofacial space infections in Germany
ConclusionsSevere MSI are a growing challenge in German health care especially among elderly patients over 80 years.Clinical relevanceSevere MSI is a promising target for prevention. There should be more focus in primary dental and medical care especially in groups depending on social support. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - April 22, 2024 Category: Dentistry Source Type: research
Acquired enamel pellicle and biofilm engineering with a combination of acid-resistant proteins (CaneCPI-5, StN15, and Hemoglobin) for enhanced protection against dental caries - in vivo and in vitro investigations
ConclusionsThe AEP modification altered the subsequent layers, affecting the initial process of bacterial adhesion of pathogenic and commensal bacteria, as well as enamel demineralization.Clinical relevanceComb group shows promise in shaping oral health by potentially introducing innovative approaches to prevent enamel demineralization and deter tooth decay. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - April 20, 2024 Category: Dentistry Source Type: research
Multi-omics analysis of immune-related microbiome and prognostic model in head and neck squamous cell carcinoma
ConclusionsThis study offers a comprehensive exploration of the ICI landscape in HNSCC. We provide a detailed scenario of immune regulation in HNSCC and report a correlation between differing ICI patterns, intratumor microbiome, and prognosis. This research aids in identifying prime candidates for optimizing treatment strategies in HNSCC.Clinical relevanceThis study revealed the microbial signatures associated with immunophenotyping of HNSCC and further found the microbial signatures associated with prognosis. The prognostic model based on IRM microbes is helpful for early prediction of patient prognosis and assisting clin...
Source: Clinical Oral Investigations - April 20, 2024 Category: Dentistry Source Type: research
Comparison of different maxillary advancement protocols in patients with unilateral cleft lip and palate: a finite element analysis
ConclusionsIn individuals with unilateral cleft lip and palate with Goslon score 4, it was observed that the skeletally anchored face mask caused more skeletal impact and displacement than both the traditional acrylic plate face mask model and the pure skeletally supported maxillary protraction model.Clinical relevanceWhen planning maxillary protraction treatment in patients with cleft lip and palate, it should be considered that more movement in the sagittal plane might be expected on the cleft side than the non-cleft side, and miniplate and screws on the cleft side are exposed to more stress when using infrazygomatic pla...
Source: Clinical Oral Investigations - April 20, 2024 Category: Dentistry Source Type: research
Improved recurrence rates and progression-free survival in primarily surgically treated oral squamous cell carcinoma – results from a German tertiary medical center
ConclusionsOur findings show a significant decrease in recurrence rates and enhanced PFS at a high-volume tertiary medical center in Germany compared to previous studies. Local recurrence was the primary form observed, with most recurrences happening within the initial twelve months post-surgery. Opting for treatment at a high-volume center and devising therapy plans in interdisciplinary tumor boards may not only enhance OS but also contribute to improved PFS.Clinical relevanceThese findings offer valuable insights for physicians regarding the post-treatment care of patients with OSCC. The results underscore the importance...
Source: Clinical Oral Investigations - April 20, 2024 Category: Dentistry Source Type: research
Efficacy of natural enzymes mouthwash: a randomised controlled trial
ConclusionUse of natural enzymes mouthwash improved signs and symptoms of xerostomia.Clinical relevanceNatural enzymes mouthwash is potentially effective to treat xerostomia, well-tolerated and safe to be used by xerostomia patients.Clinical trial registration numberThis study was retrospectively registered in ClinicalTrials.gov ID NCT05640362 on 7 December 2022. (Source: Clinical Oral Investigations)
Source: Clinical Oral Investigations - April 19, 2024 Category: Dentistry Source Type: research
